terapi hipotiroid
Post on 02-Jan-2016
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TERAPI HIPOTIROID
Thyroid Hormone Replacement Therapy
Synthetic levothyroxine (T4) Synthetic liothyronine (T3)
Synthetic levothyroxine (T4)
FarmakodinamikDosis :Anak 10-15 mcg/kg/hariDewasa 1.7 mcg/kg/hari
1x/hari Farmkokinetik
Diminum 30menit-1jam sebelum makanMonitor setiap 2 bulanPuncak kerja 2 pekanWaktu paruh 3 pekan
Synthetic liothyronin (T3)
Dosis : 20mcg 3-4x/hari 3-4x lebih poten Farmakokinetik :
puncak kerja 3 hariLama kerja 1 pekan
Kelebihan T4
Stabil Murah Rendah reaksi alergi Monitor mudah Dosis sekali sehari
Indikasi
Pasien muda : full replacementherapy Koma miksedema : loading dose T4 300-
400 mcg I/V initially 50 mcg daily Hypothyroidism and pregnancy : daily
dose, adequate, monitored
Kontraindikasi
Pasien tua Pasien dengan penyakit jantung
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