pre-feasibility report of m/s vega life sciences...

Pre-Feasibility Report of M/s Vega Life Sciences Pvt.Ltd

Pashamylaram Unit of 14

PREFEASIBILITY REPORT OF M/s. VEGA LIFE SCIENCES PVT.LTD

1. Introduction of the project

M/s Vega Life Sciences Pvt.Ltd is promoted by Sri K.Venkat Reddy and Smt.K.Vasundhara. Industry proposes to expand the unit to manufactures Bulk Drugs, Intermediates, chemicals in addition to solvent recovery. At present industry is recovering only solvents. The unit is located on plot No plot No.D-22, Phase-1, IDA,Pashamylaram,Patancheru Mandal, Medak dist. a notified industrial area. M/s Vega Life Sciences Pvt.Ltd has purchased the unit from M/s Jayamahima Chem Pvt.Ltd. Total land area of the unit is 4306 SQM.

1.1 Need of the project

The Indian pharmaceutical industry valued at $ 12 billion has portrayed tremendous progress with reference to infrastructure development, technology base creation and a wide range of production. The pharmaceutical industry produces bulk drugs belonging to major therapy groups. India ranks 4th worldwide accounting for 8 percent of the world’s production (in terms of volume) and 13th in terms of value. It is estimated that by the year 2010, the Indian pharmaceutical industry has the potential to achieve over Rs.1, 00,000 crore in formulations and bulk drug production. The industry now produces bulk drugs belonging to all major therapeutic groups requiring complicated manufacturing process and has also developed Good Manufacturing Practices (GMP) facilities for the production of different dosage forms. The pharma industry exports drugs and pharmaceuticals worth over $4.5 billion. It ranks 17th in terms of export value of bulk actives and dosage. Indian exports cover more than 200 countries including the highly regulated markets of USA, Europe, Japan and Australia.

At a growth rate of 9 percent per year, the pharmaceutical industry in India is well set for rapid expansion. As a result of the expansion, the Indian pharmaceutical and healthcare market is undergoing a spurt of growth in its coverage, services, and spending in the public and private sectors.



2. Project Description

The proposed industry intends to produce the products given below. The products are divided into bulk drugs, Intermediates, Chemicals and solvent recovery by distillation. The installed capacity for bulk Drugs and intermediates is 65.00TPM, for chemicals 90TPM and for solvent recovery 450TPM.

Industry proposes to produce 2.0 TPD either from bulk drug group or intermediate group; 3.0 TPD from chemicals group; 15.0 TPD solvent recoveries.

2.1 Project details

Sl.No Description Details I Name of the project Vega Life Sciences

Pvt.Ltd II Location Village Pashamylaram Area APIIC District Medak State Telangana III Land use pattern of the

industry

Total Land area in SQM 4306.00 Built‐up area 1989.00 Production Block 1690.00 Storage yard 300.00 Roads 800.00 Green Belt 1446.00 ETP 70.00



2.1.2 List of products

• Bulk Drugs

Sl. No Name of the product Production TPM

1. Carvedilol phosphate 2.50

2. Citalopram Hydrobromide 10.00

3. Closantel sodium 5.00

4. Esomeprazole magnesium trihydrate 1.50

5. Fexofinadine hydrochloride 2.00

6. Fosfomycin trometamol 3.00

7. Gaba-pentin 3.00

8. Itraconozole 2.00

9. Lansoprazole 3.00

10. Lornoxicam 4.00

11. Montelukast sodium 3.00

12. Omeprazole 5.00

13. Ondansetron 3.00

14. Oxyclozanide 5.00

15. Ritonavir 3.00

16. Rosuvastatin calcium 3.00

17. Setraline hydrochloride 2.00

18. Sparfloxacin 2.00

19. Terbinafine hydrochloride 3.00

Total 65.00



• Intermediates

Sl. No Name of the product Production TPM

1 Tri Chloro Salisylic Acid 3.00 2 5-AminO-2-Hydroxy Benzoic acid 2.00 3 5-Amino-2-dibenzylamino-1,6-diphenyl-hex-4-en-3-

one 2.00

4 2-Amino-6-chloro-3-nitro pyridine 3.00 5 4-Chloro butyryl chloride 3.00

• Chemicals

Sl.No Name of the product Production TPM

1 Tributyl Tin chloride 90 2 L-Menthol 90

3 Dicyclo Hexylcarbomidiimide

90

• Solvent Recovery

Sl.No Name of the product Production TPM

1 All solvents 450

Industry proposes to produce

• 2.0 TPD either from bulk drug group or intermediate group • 3.0 TPD from chemicals group • 15.0 TPD solvent recovery



2.2 Project site selection

The main reason for selecting this site is its affordability and an existing unit. Also very near to state Highway connecting Hyderabad and Mumbai. Availability of the supporting facilities including skilled man power is available around the area.

There are no reported endangered, threatened or rare plant species at the plant site or within the 10 kms radius of the plant that need to be conserved. No discernible impacts on terrestrial life. No migration route to avifauna. The development of greenbelt will improve aesthetics in surrounding area.

Topographical map of the Area



General Location on Google Map

Site index

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recovered by distillation for next batch.Thus pharma is isolated and purified with water wash and sometimes with crystallsation with a suitable solvent.

2.4 Typical flow chart

Active inputSolventCatalyst

Reactor Solvent recovery

CentrifugeWater Waste water

Product Solvent recovery

All the solvents will be first neutralized either with base or acid solution separately. Water will be removed by separation and then the same will be taken into a kettle fro distillation.

• Typical flow chart

Spent SolventSodium Chloride Reactor

Reboiler

Distillation column

Steam

Storage Tank

Organic Residue

Sodium Chloride solutionto recovery and reuse

2.5 Raw materials requirement

Manufacturing process involves the use of chemicals, organic solvents either directly as reactant or for extraction of a product of interest from the reaction



mixture and spent solvents. Raw materials required for the process is mostly bought from the local (indigenous) market. Spent solvents will be obtained from nearby industries. Coal is used in the proposed boiler of 2 MT/hour. The coal consumption is about 3.0 Tons per day. Diesel used for DG set of capacity 125KVA will be about 40 liters/hr at full operation load.

2.6 Resource ReCycling Optimizing /Recycling

All efforts will be made by the industry to carry out R& D on the isolated by‐products / wastes to minimize wherever possible. However R& D is a continuous process, where improvement in the process adopted by the industry, waste minimization etc can be worked out as the project progresses.

2.7 Utilities

Sl.No Description 1 Coal Fired

Boiler 2TPH

2 Chilling Plant 200TOR3 Cooling

Towers 400TR

2.8 Water requirement

The total water requirement of the plant is 54M3/day. The water needs for the industry will be met from public supply.

2.9 Power requirement

The total power requirement of the plant is 150HP and is met from public supply. DG set of 125KVA will be used only as stand by.

2.10 Wastewater generation & Proposed Treatment method



The wastewater generated from the plant will be about 24 m3/day. Out of this about 1.50 KLD will be domestic wastewater. Trade effluent will be collected by gravity from all sources into a collection tanks.

The effluent will be pumped to the above ground level R.C.C. tanks lined with Acid proof tiles for storage and neutralization and then the effluent will be sent to Multiple Effect Evaporators. Condensate will be reused appropriately. Salts from the MEE evaporation system will be collected and sent to TSDF. Domestic waste water will be sent to septic tank.

2.11 Solid waste generation & Proposed Treatment method

Solid waste generated from the plant is of two categories. Inorganic and Organic Solid waste. Inorganic solid waste about0.0.42TPD will be sent to TSDF for secured land fill. Organic solid waste about 0.72 TPD will be sent to cement plants for incineration. Coal ash from boiler will be sold to suitable buyers.

3. Site Analysis Industrial area is well connected by Road and rail. It is beside to NH9 connecting Hyderabad and Mumbai. Project area is a notified industrial area. The area is well away from sensitive sites such as National parks, Wild life sanctuaries, biosphere reserves and religious places. Singur Dam, a water source is 48 Km away from industrial area. Nearest Human Habitat is 3.5 Km Temperatures in the region vary between 360C and 430C during day time and during night varies between 230C and 270C in summer season. During monsoon season temperatures varies between 290C and 300C during day time and 200C and 220C during night time. In winter season temperature varies between 200C and 100C.Relative humidity is between 50% and 55%during monsoon and during winter is between 30% and 40%. Nearly 67% annual rainfall is between June and September. A few showers are also received during the October. 4. Brief Planning



Industry being a multi product manufacturing unit, it works in shifts. It works round the clock. Therefore transportation of workers is a not a major point. Industry will engage private operators for the purpose. Since industry is near to the human habitat, industry does not have any plans to construct houses for the employees.

5. Proposed Infrastructure

Total Land area in SQM 4306.00

Built‐up area 1989.00Production Block 1690.00Storage yard 300.00Roads 800.00Green Belt 1446.00ETP 70.00

6. Rehabilitation and Resettlement

Since the industry is proposed on a notified industrial area, R & R is not required. By providing direct and indirect employment to the locals and also by facilitating the villages by conducting various developmental programs in a phased manner in association with local bodies, area will continue to develop socio‐economically.

7. Post project monitoring

The industry has definite environmental monitoring program to monitor the Ambient Air Quality as well as Stack Emissions. The industry will engage recognized laboratories to carry out all necessary monitoring parameters for the industry. Qualified staff will be appointed for the purpose of Operation and maintenance of the pollution control facilities. Stand‐by facilities will be provided to all the pumps so as to ensure fail proof treatment.

8. Greenbelt development

8.1 Objective



The purpose of a green belt around the plant site is to capture the fugitive emission, attenuate the noise generated and improve the aesthetics.

The green belt at the project site will form an effective barrier between the plant and the surroundings. Open spaces, where tree plantation may not be possible, will be covered with shrubs and grass to prevent erosion of topsoil. Adequate attention will be paid to plantation of trees, their maintenance and protection. A green belt will be developed around the periphery of the plant. Open spaces within the factory will be converted to green areas in the form of lawns or flowering plants.

8.2 Plant species for green belt.

A wide range of plant species will be planted in and around the premises to help capture the fugitive emission and noise levels form the plant premises. This wide range covers plants of

• Fast growing type • With thick canopy cover • Perennial green nature • Native origin

A specialist in horticulture may be appointed to identify any other native species and also supervise greenbelt development.

8.3 Design of Green Belt

As far possible the following guidelines will be considered in proposed green belt development. Shrub and trees will be planted in encircling rows around the outer three rows (away from planted side)

The short trees (<10 m height) will be planted in the first two rows (towards plant side) of the green belt. The tall trees (>10 m height) will be planted in the outer three rows (away from plant side).

• Planting of trees in each row will be in staggered orientation. • In the front row, shrubs consisting of Callistemon, Prosodies etc. Will be

grown. • Since the trunks of the tall trees are generally devoid of foliage, it will be

useful to have shrubs in the fronts of the trees so as give coverage to this portion.



The spacing between the trees will be maintained slightly less than the normal spaces, so that the trees may grow vertically and slightly increase the effective height of the green belt.

9. Recycle

All efforts will be made by the industry to carryout R&D on the isolated by‐products / wastes to recycle / reuse wherever possible. However, R&D is a continuous process, where improvement in the processes adopted by the industry, waste minimization etc can be worked out as the project progresses.

10. Environment management cell

The unit will provide upgraded Environment Management cell as below:

10.1 Environment Management Cell

The Environment Management Cell shall include:

1. Manager (Head of Environment Cell) 2. Process in charge from production 3. In charge Maintenance Department 4. In charge Operation ETP, Air Pollution Control Division, Solid waste

management with Chemist 5. A representative of Environmental Consultants (Adviser)

11. Handling of raw materials and finished materials

The industry is proposed to store the raw materials (maximum seven days storages capacity).These raw materials and finished goods will be the ware house as per safety norms.

12. Hazardous Chemical, waste and Risk Assessment

Bulk Drug & intermediate manufacturing industry has to handle many such chemicals that are hazardous waste is generated. The industry will provide special training to the workers handling Hazardous chemical / wastes. The industry will engage safety consultants to prepare a risk assessment and suggest safe handling and safe storage of Hazardous wastes for the proposed project. Only highly trained personal with personal projective Equipments (PPE’s) will be allowed to handle such chemicals or under strict supervision.

13. Project schedule and cost estimates



Industry proposes to commence the construction activity as soon as Environmental Clearance and CFE are granted by respective authorities. It is estimated that 12 months is required to complete the construction and one more month for trial production and another two months to start commercial production.

The Total Gross proposed investment in Land, Buildings and Plant & Machinery is Rs.271 Lacs and the Unit has been registered under Small Scale Industry. Industry has allocated an amount of about Rs.40.00 Lacs for Environmental Protection measures and 1.50 lacs for green belt development

pre-feasibility report of m/s vega life sciences...

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