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  • Corporate Capabilities

    1580 McLaughlin Run Road

    Pittsburgh, PA 15241

    412-257-4461www.pprresearch.com

    Quality Research Today for a Better Tomorrow

  • Primary Physicians Research is an established clinical research provider

    We offer:

    10 independent, community-based research sites

    2 multi-specialty sites

    Over 25 years of experience

    Over 700 trials.

    Dedicated QA/QC department, assuring quality conduct as well as patient safety

    70+ physician network of investigators

    A rapidly growing database of over 300,000 patients

    Nearly 33,000 study participants (2005-2011)

    A strong history of high-quality performance

    Strong Enrollment

    Reliability

    Clean Data

    Quick Turnaround

  • History of strong performance

    Phase I-IV and OTC clinical trial capabilities

    Ability to accommodate specialist trials

    Able to handle large, quick enrollments, due to seasonal issues

    Consistent history of achieving and exceeding contracted enrollment

    Overenrolled in over 30% of studies from February 2006 February 2011

    Primary Investigators, Sub Investigators, and highly trained staff at each site to oversee and execute the study protocol

    Fully equipped neighborhood offices that offer convenience and familiarity to study subjects.

    A proven track record in pediatric and adult research.

  • PPRs Facility PPRs dedicated research facility is located within the Jefferson Regional Hospital

    State of the art on-site

    lab capabilities Separate monitor

    room with high -speed

    Internet, Fax, Phone.

    On site PI

    Comfortable waiting room

  • Studies Conducted 300

    Total Enrollment Since 2002 30,800

    Total Completed 29,974

    Studies conducted between January 2002 - February 2011

    Patient completion %

    Patient drop-out %

    Note: The above is all-inclusive of studies taken on by PPR during the period - without regard to size, type, ease/difficulty or

    continuance/discontinuance.

    2.5-Year Average Study Yield

    Jan 2008- February 2011

    3.3%

    96.6%

    97% of patients completed study protocols

  • Note: The above represents PPRs mix of business by number of studies across its 7 largest customers over the last 10 years

    Merck24%

    Abbott4%

    GSK29%

    Sanofi15%

    Lilly1%

    Pfizer/Wyeth14%

    Novartis13%

    7 Largest Sponsors 10 Year Snapshot

    PPR has a strong history with numerous pharmaceutical companies:

  • Our quality assurance goal is to achieve, sustain, and improve quality in all

    aspects of research within the clinical site arena.

    PPRs QA Department has been organized to drive a data quality focus throughout the organization. This is achieved by:

    Training staff on an ongoing basis

    Monthly meetings to identify and correct potential adverse trends in data quality

    A Quality Assurance Liaison visits sites monthly to correct identified problems and trends and works with PIs to ensure adherence to protocol

    and GCPs

    In-house audits are performed and quality indicators are reviewed on a per trial basis

    Identifying and implementing best practices for delivering quality data

    Quality Assurance

  • Clinical Conductor manages the large amounts of data involved with the

    operation of a clinical trial.

    Some of the benefits of using a CTMS include:

    Improves recruitment efficiency

    Better management of budgets and financials

    Tracks advertising responses

    Full oversight of multiple trials at multiple sites

    Strong Clinical Trial Management Information System

  • Recruitment and marketing: A top priority

    PPR has a marketing and site recruitment team who is solely dedicated to patient enrollment

    Marketing techniques play a pivotal role in how targeted patients become aware of clinical trials

    In-house marketing staff creates advertising and marketing tools that are used by sub-investigators and site personnel to increase enrollment

    Staff adheres to ICH guidelines in obtaining IRB approvals for marketing tools

  • PPR utilizes online marketing resources and social media tools for patient

    recruitment

    PPR maintains an active online presence through its website, social media

    networks, and craigslist

    Recent Accomplishments:

    Used Craigslist.com to recruit nearly 75% of goal

    patients in an osteoarthritis

    study with a contracted goal

    of 20 patients

    Used Craigslist.com to enroll over 100% of the set 40

    patient goal in a Womens Health study

    Online marketing and social media tools

  • Trial Experience

  • Diptherial/Pretussis/Tetanus

    DTaP

    Tetanus/Diphtheria

    Varicella

    eIPV

    Rotavirus

    Influenza (intranasal

    Influenza (injection)

    Influenza (cellular)

    Meningococcal A,C,Y,W-135

    Meningococcal B

    Lyme Disease

    Parainfluenza

    Pneumococcal

    DTaP/IPV/Hep B (Pediarix)

    Haemophilus influenza type B

    Hepatitis A

    Hepatitis B

    Human Papillomavirus

    Plague

    Respiratory Syncytial Virus (RSV)

    Anthrax

    Diphtherial/Pertussis/Polio/Tetanus

    Meningococcal A,C,W,Y

    MMRV

    Herpes Simplex Virus

    Hepatitis AB

    PIV3RSV

    Dtap/Hib/IPV (Pentacel)

    PPR has conducted numerous vaccine trials including:

  • Asthma

    Osteoporosis

    Osteoarthritis

    Obesity

    Herpes simplex

    Antivirals

    Diabetes

    Strep throat

    Antipyretics

    Lipids

    Influenza

    Pharmacokinetics

    Migraine

    Atrial Fibrillation

    Topical Otologicals

    Topical Ophthalmologics

    Contraceptives

    Arthritis

    Back pain

    Pharyngitis

    Acute bronchitis

    Chronic bronchitis

    Sinusitis

    Pneumonia

    Otitis media

    Bacterial vaginosis

    Infant formula

    Hypoactive Sexual Desire Disorder

    PPR has conducted numerous therapeutic and nutritional trials:

  • Our Clients

  • Note: The above is meant to show PPRs substantial client base developed over time. It should be noted that some of the above listed clients have since merged, been acquired or otherwise joined with competitors.

    Aventis

    Abbott

    Advancis

    Alcon

    Allergan

    AlmirallProdesfarma

    Aviron

    BioCryst

    Bristol Myers Squibb

    Cephalon

    Chiron

    Dimethaid

    Dynavax

    Dynport

    Genentech

    Gilead Sciences

    GlaxoSmithKline

    GlaxoWelcome

    Inspire

    Iomai

    Johnson & Johnson

    KV Pharma

    Eli Lilly

    Mead Johnson & Company

    MedImmune

    Merck

    NABI Pharmaceutical

    Novartis

    Ortho-McNeil

    Osiris Therapeutics

    Pfizer

    Pharmacia

    Protein Sciences

    Roche

    RWJ

    Sanofi

    Sanofi Aventis

    Sanofi Pasteur

    Sepracor

    Schering-Plough

    Shire

    Takeda

    VaxGen

    ViroPharma

    Wyeth

    PPR has a strong history with numerous pharmaceutical companies:

  • Advanced Biologics

    Covance

    I3 research

    Icon

    MDS

    OmnicareCR

    Parexel

    Pharmanet

    PPD

    Quintiles

    United Biosource Corp

    PPR is proud of its working relationships with government agencies

    The National Institutes of HealthWorking on protocols that have been initiated by the NIH

    The Department of Defense Worked on vaccines to protect military men and women over the last 5 years

    The Division of Microbiology and Infectious Diseases (DMID)Approved by the DMID to work on vaccine trials in collaboration with NIH and VTEU sites

    Created QA/QC program that has been approved by the DMID

    Subcontractor for the Vaccine and Treatment Evaluation Units (VTEU) program Partner with the University of Saint Louis to work with them in numerous vaccine trials

    PPR has strong relationships with CROs and others:

  • PPR provides:

    Experienced leadership oversees the key functions supporting trial success

    Clinical staff receives extensive training and is dedicated solely to conducting research

    Consistent and strong enrollment

    Quality data

    A team dedicated to delighting our clients!

  • PRESIDENT & CEO

    Paul E. Curley

    Phone :412-257-4461 ext 212

    Cell: 610-745-9155

    curleyp@pprresearch.com

    EXECUTIVE DIRECTOR, COMMERCIAL OPERATIONS

    Carol L. Miller, LPN, CCRC

    Phone :412-257-4461 ext 127

    Cell: 724-518-9531

    millerc@pprresearch.com

    BUSINESS DEVELOPMENT

    Corry Knuth

    Phone :412-257-4461 ext 126

    Cell: 724-570-4798

    knuthc@pprresearch.com

    Our clinical research team:

    Primary Physicians Research welcomes the opportunity to speak with you to provide more

    information about our experience conducting clinical trials or for the opportunity to conduct a

    clinical trial for you. Please contact us: