United States Patent

US007175599B2

(12) (10) Patent N0.: US 7,175,599 B2 Hynynen et a]. (45) Date of Patent: Feb. 13, 2007

(54) SHEAR MODE DIAGNOSTIC ULTRASOUND 5,426,979 A * 6/1995 Kantorovich et a1. ....... .. 73/628 5,606,971 A 3/1997 SarvaZyan ........... .. 128/660.02

Inventors: Kullervo Hynynen’ Med?elds MA 5,752,515 A 5/1998 J01€SZ et a1. ........... .. (Us). Gregory T_ Clement Boston 5,810,731 A * 9/1998 Sarvazyan et a1. 600/438

M A ins) ’ ’ 6,135,960 A 10/2000 Holmberg ....... .. 600/447 6,561,981 B2* 5/2003 Bonnefous . 600/443

. . . 6,585,647 B1* 7/2003 W' d .... .. 600/437 (73) Asslgnee: Bngham and women’s Hospltal’ Inc" 6,638,219 B1 * 10/2003 AS16111‘; a1. 600/437

Boston’ MA (Us) 6,764,448 B2* 7/2004 Trahey et a1. 600/437 _ _ _ _ _ 6,770,033 B1 * 8/2004 Fink et a1. ................ .. 600/443

( * ) Not1ce: Subject to any d1scla1mer, the term of this _ patent is extended or adjusted under 35 (comlnued)

U~S~C~ 154(b) by 315 days~ FOREIGN PATENT DOCUMENTS

(21) Appl. N0.: 10/822,181 W0 WO 99/56829 11/1999

(22) Filed: Apr. 9, 2004 (Commued) OTHER PUBLICATIONS

(65) Prior Publication Data _ _ _ Internatlonal Search Report for PCT/US2004/011374, malllng date:

US 2004/0210135 A1 Oct. 21, 2004 Jul. 21, 2004.

Related US. Application Data (Continued)

(60) Provisional application No. 60/463,589, ?led on Apr. Primary Examineriprancis 1' JaWOrski _ 17 2003_ (74) Attorney, Agent, or FirmiShane H. Hunter; MlntZ,

’ Levin, Cohn, Ferris, Glovsky and Popeo, PC. (51) Int. Cl.

A61B 8/00 (2006.01) (57) ABSTRACT

(52) US. Cl. .................................................... .. 600/443 A method of diagnosing a Subject by delivering ultrasound 0f Classi?cation Search .............. .. Signals using Shear Waves includes a portion of an

609/440*441, 443, 447, 449*450; 7_3/625*626 ultrasound mainbeam to a bone surface at an incident angle See apphcatlon ?le for Complete Search hlSIOI'Y- relative to the surface of the bone to induce shear Waves in

(56) References Cited the bone, energy in the shear Waves forming a substantial

U.S. PATENT DOCUMENTS

3,996,792 A * 12/1976 Kubota et a1. .............. .. 73/611

4,221,132 A 9/1980 Poole ........ .. 73/620

4,789,969 A * 12/1988 Naville . . . . . . . . . . . . .. 367/36

4,817,614 A 4/1989 Hassler et a1. ....... .. 128/660.05

5,197,475 A * 3/1993 Antich et a1. ............. .. 600/437

part of energy of ?rst ultrasound Waves at a desired region in the subject through the bone, detecting at least one of re?ected and scattered energy of the applied ultrasound mainbeam, and analyzing the detected energy for a diag nostic purpose.

46 Claims, 23 Drawing Sheets

10 Z

Phase Shift 2e, Ampli?er g, a, Phase Shifl Q2 Ampli?er 143 C13 Frequency ' Phase Shift 25,

Generator Phase Shift 2Q,

Phase Shift 5,

Phase Shift 25"

US 7,175,599 B2 Page 2

US. PATENT DOCUMENTS W0 W0 03/017843 A1 3/2003

6,899,680 B2* 5/2005 Hoff et a1. 600/449 2002/0016557 A1 2/2002 Duane et a1. .... .. 601/2

5885932233 21 $5885 $535? 3.1;; ........ .111 288/333 OTHER PUBLICATIONS :1: .... we

WO

FOREIGN PATENT DOCUMENTS

WO 03/013654 Al 2/2003

Jul. 20, 2004.

* cited by examiner

U.S. Patent Feb. 13, 2007 Sheet 1 0f 23 US 7,175,599 B2

LII! FIG. 1

U.S. Patent Feb. 13, 2007 Sheet 2 0f 23 US 7,175,599 B2

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U.S. Patent Feb. 13, 2007 Sheet 3 0f 23 US 7,175,599 B2

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U.S. Patent Feb. 13, 2007 Sheet 4 0f 23 US 7,175,599 B2

U.S. Patent Feb. 13, 2007 Sheet 5 0f 23 US 7,175,599 B2

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U.S. Patent Feb. 13, 2007 Sheet 7 0f 23 US 7,175,599 B2

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U.S. Patent Feb. 13, 2007 Sheet 8 0f 23 US 7,175,599 B2

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U.S. Patent Feb. 13, 2007 Sheet 10 0f 23 US 7,175,599 B2

[110 Position Array 112

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Determine Desired Property(ies)

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U.S. Patent Feb. 13, 2007 Sheet 13 0f 23 US 7,175,599 B2

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U.S. Patent Feb. 13, 2007 Sheet 14 0f 23 US 7,175,599 B2

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U.S. Patent Feb. 13, 2007 Sheet 15 0f 23 US 7,175,599 B2

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U.S. Patent Feb. 13, 2007 Sheet 16 0f 23 US 7,175,599 B2

Coded Excitation A-line through gel and glass bead

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U.S. Patent Feb. 13, 2007 Sheet 17 0f 23 US 7,175,599 B2

Coded Excitation — Cross Correlation with X-ducer Response

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U.S. Patent Feb. 13, 2007 Sheet 18 0f 23 US 7,175,599 B2

A-lines, Shear Wave A-lines, Longitudinal

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