بيوشيمي باليني جلسه ششم joshaghanihr@goums.ac.ir

joshaghanihr@goums.ac.ir

MW= 62000TetramerEach monomer 1Tyroxine (TBPA)Pre alb RBP + Vit A 182 aaRich of TrpBeta sheet ~ 2 daysBest method for detection = immunologic & nephlometric

MW= 60000 ~ 17 daysFunctions:Oncotic pressureCarrier proteinReservoir for aa

Carrier protein function of AlbThyroxinBilCortisolCaEstrogensFFAMgCu.

Glycolated Alb = FructosamineIn Cycel cell anemia ,Thal & Hemolytic disease is usefulSyndrom nephrotic

- 1

- 1 (AAT)

3 phenotype :MM, MZ, ZZEmphysema & cirrhosisAcute phase protein

- Gc

Gc- (DBP)MW=51000Phenotype: 1-1, 2-2, 1-2Each DBP 1 Vit DSyndrom nephrotic DBP Ca

-2

-2 (AMG)

MW = 725000Inhibitor of proteasesSyndrom nephrotic

(HP)MW= ~ 4 daysHP HbIn intra venus hemolytic disease Phenotype : 1-1, 1-2, 2-2Acute phase protein

(Cer)MW= 132000Cer 6 CuOxidase enzymeFe 2+ Fe 3+Contraceptive drug & pregnancy Acute phase proteinWilson disease

Wilson diseaseSerum CerSerum CuUrine CerUrine Cu

Kayzer Fisher ring

-

- LDLPosition of band variable in fasting & eating

MW=79550A glycoproteinEach transferin 2 FeSerum normal range: 200-400 mg/dl (TIBC)In Iron deficiency & pregnancy Iron TIBC

Percipitation of ironCirrhosisDiabetesCardiomyopathyArteritis

TIBC= UIBC + Iron

Saturated percent (%)=(Iron/TIBC)X 100

In normal condition: 30% transferin saturated

Asialotransferin in CSF, ..,

MW=70000GlycoproteinHemopexine Heme

Band between beta & gamaMW= 340000plasma normal range: 100-400 mg/dlDimer (a-, B-, )Acute phase protein ESR

CRP

CRPMW= 118000-144000GlycoproteinSerum normal range: 470-1340 ng/dlAcute phase protein