nanopharmacology and nanotechnology
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TRANSCRIPT
NANOTECHNOLOGY,NANOPHARMACOLOGY
National O.O. Bogomolets Medical University
E.O.Paton Electric Welding Institute Kyiv, Ukraine
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NANOTECHNOLOGY
Nanotechnology is a complex of scientific knowledge, methods and meansaimed at controllable assembly (synthesis) of various substances, materials and itemswith the linear size of structural elements of up to 100 nm (1 nm – 10-9 m; 1 nm =10 Ǻ) from individual atoms and molecules.
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NANOTECHNOLOGY: PRODUCING OF NANOPARTICLES
• Mechanical disintegration.• Chemical synthesis.• Photochemical synthesis.• Vacuum evaporation methods.• Microbiological synthesis.
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ELECTRON BEAM TECHNOLOGYElectron beam evaporation of materials in vacuum differs from other methods of vacuum evaporation – thermal and ion-plasma, primarily, by its versatility, technological flexibility, efficiency and cost-effectiveness.
The electron beam is one of the most effective heat sources. At collision of the flying electron with the solid surface the main fraction of kinetic energy of the electrons is converted into thermal energy in a thin surface layer 1 – 2 μm thick. Therefore, at heating by the electron beam the heat source is in the solid itself and ensures the maximum complete conversion of electric energy into thermal energy.
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ELECTRON BEAM TECHNOLOGYModern electron beam guns of 50 – 100 kW power allow evaporation of metallic and non-metallic substances at sufficiently high rates, approximately up to 10-2 g · cm-
2 · s-1. Evaporators consisting of a copper water-cooled crucible (cylinder), into which the evaporation material is placed in the form of ingot (cast or compacted) of 25 to 70 mm diameter, have become the most widely applied in practice.
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SCHEMATIC OF ELECTRON BEAM EVAPORATION
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NANOPARTICLES Fe3O4
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ELECTRON BEAM TECHNOLOGY
The International Center for Electron Beam Technologies of the E.O. PatonElectric Welding Institute designed and organized manufacturing of laboratory, pilotproduction and production electron beam equipment for realization of the considered variants of the technology.
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More than 10 units have already been manufactured for universities, scientific centers and industrial enterprises of the USA, China, Canada and India.
ELECTRON BEAM TECHNOLOGY
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ELECTRON BEAM TECHNOLOGYModern electron beam nanotechnology of producing advanced nanomaterials and aircraft engine construction, has a real potential of further scientific and economic advances in medicine, pharmacology and pharmacy, in particular in development and manufacturing of :
• 1. Heterogeneous inorganic and some variants of organic materials and
• coatings, in the solid and liquid states, in a broad range of shapes, nano- and
• microsizes of their structural elements.• 2. Magnetic nanofluids.• 3. Consolidated or discrete nanostructures of carbon and
its compounds.• 4. Filters.• 5. Sorbents.• 6. Graded biological coatings.• 7. Catalyst carriers, catalysts and catalysis devices.• 8. Components of medical instruments and equipment
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SILICA NANOPOWDER
Scientists from the O.O. Chuiko Institute of Surface Chemistry (The National Academy of Sciences of Ukraine) and Vinnitsa National Pirogov Memorial Medical University developed a drug “Silics” - new sorbent of polydirected action, based on highly disperse amorphous silica amorphous silica nanopowder, obtained by chemical synthesis.
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At the Department of Pharmacology and Clinical Pharmacology (National O.O. Bogomolets
Medical University) drugs, created using nanotechnology, including those based on silica
nanopowder, are studied.
Unlike other sorbents silica nanopowder - a powder of aporose structure consisting of
nanoparticles with size 5-20 nm
SILICA NANOPOWDER
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FINE SILICA SUSPENSION: DECREASING TOXICITY OF ANTITUBERCULOUS DRUGS
0
20
40
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80
100
120
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160
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DL
50,
мг/
кг
1 2 3 0
500
1000
1500
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3500
DL
50,
мг/
кг
1 2 3
0
1000
2000
3000
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DL5
0, м
г/кг
1 2 3
Isoniazid Pyrazinamide
Ethambutol
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FINE SILICA SUSPENSION: DECREASING TOXICITY OF ANTITUBERCULOUS DRUGS
0
10
20
30
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50
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ASAT ALAT
Un
its/
L
0
10
20
30
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50
60
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90
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Triglycerides Cholesterol
Mg/
dL
intact animals
Isoniazid + silica nanopowder
Isoniazid
Isoniazid + silica nanopowder +PEO-400
Isoniazid + Activated charcoal 0
10
20
30
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90
100
Bilirubin, g/L
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FINE SILICA SUSPENSION: DECREASING HEPATOTOXICITY OF ETHYL ALCOHOL
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120
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ALAT ASAT
Un
its/
L
0
20
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100
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Triglycerides Cholrsterol
Mg/
dL
0
5
10
15
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Bilirubin, g/L
Intact animals Ethanol + silica nanopowder
Ethanol
Ethanol silica nanopowder +PEO-400
Ethanol + activated charcoal
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AG NANOPARTICLES FROM DRIED WATER SOLUTION
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EFFECTIVE CONCENTRATIONS OF AG-NANO IN COMPARISON WITH З AGNO3
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Ag-нано AgAg-nano
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NANOCOMPOSITES OF SILVER AND COPPER
• Using electron-beam technologies were received composite nanoparticles of silver and copper.
• It was established that this composite by antimicrobial activity much more potent than
silver nanoparticles and copper nanoparticles.
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PROSPECTS OF INVESTIGATIONS
1. Development of new technologies of nanoparticles manufacturing, especially composites of organic and inorganic origin.
2. Design of new dosage forms for external and internal application and inhalation.
3. Study the therapeutic mechanisms of action of new nanodrugs.
4. Investigations of nanomaterials toxicity.
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CONTACTSCompany: National O.O. Bogomolets Medical University
Department: Pharmacology and Clinical Pharmacology
Contact Person: Prof. Dr. I.S. Chekman
Address: 03057, Ukraine, Kyiv, Peremogy av., 34
Phone / Fax: +380675063769
Email: [email protected]
Web: www.nmu.edu.ua
Fields of Activities:
PRECLINICAL TRIALS: toxicological, microbiological, virusological, histochemical, immunological, biochemical, electron microscopy and gas chromatography investigations of drugs. Department specializes in drugs acting on cardiovascular system and investigates genetically spontaneously hypertensive rats.NANOMEDICINE: nano-structured metals and alloys, magnetic materials, nanodispersed silica.QUANTUM PHARMACOLOGY: electronic properties of drug molecules (antihypertensive, metabolic drugs), QSAR study alpha1-adrenergic blockers.
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CONTACTSCompany: E.O.Paton Electric Welding Institute
Contact Person: Dr. Yuriy Kurapov
Address: 68 Gorky St., Kiev – 150, 03150 Ukraine
Phone / Fax: + 38 044 287-31-66
Email: [email protected]
Web: http://www.paton.kiev.ua/
Fields of Activities:
Research, development and experimental consignments of samples production of medical-biological heterogeneous nano-structure materials by electron-beam technology of atomic-molecular beams. 1.Colloidal systems, first of all, magnetic nano-liquids.2.Consolidated and discrete nanostructures ofcarbon and its compounds.3.Sorbents.4.Filters.5.Gradient biological coatings.6.Catalysts and bearers of catalysts.