gnipst bulletin 38.2

8/10/2019 GNIPST Bulletin 38.2

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17 th October, 2014 Volume No.: 38 Issue No.: 02Vision

TO REACH THE PINNACLE OF GLORY AS A CENTRE OF EXCELLENCE IN THE FIELOF PHARMACEUTICAL AND BIOLOGICAL SCIENCES BY KNOWLEDGE BASED

LEARNING AND PRACTICE

ontentsMessage from PRINCIPALEditorial boardHistorical article

News UpdateKnowledge based ArticleDisease Related BreakingNewsUpcoming EventsDrugs Update

Campus NewsStudents SectionEditors NoteArchive

GNIPST Photo Galleryor your comments/contributionR For ack-Issues , ailto:[email protected]

GURU NANAK INSTITUTE OF PHARMACEUTICALSCIENCE AND TECHNOLOGY

We b si t e : ht t p: / / gni ps t. a c. i n
https://plus.google.com/u/0/photos/111714720327580099858/albums/5897323676427099873?sort=7mailto:[email protected]:[email protected]:[email protected]://plus.google.com/u/0/photos/111714720327580099858/albums/5897323676427099873?sort=7


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MESSAGE FROM PRINCIPAL

" It can happen. It does happen. But it can't happen if you quit ." Lauren Dane.

We are what we repeatedly do. Excellence then is not an act, but a habit . Aristotle

It gives me immense pleasure to pen a few words for our e-bulletin. At the onset I would like to thank thelast years editors and congratulate the newly selected editors for the current year.

Our first consideration is always in the best interest of the students. Our goal is to promote academicexcellence and continuous improvement.

I believe that excellence in education is aided by creating a learning environment in which all learners aresupported in maximizing their potential and talents. Education needs to focus on personalized learningand instruction, while promoting an education system that is impartial, universally accessible, and meetingthe needs of all students.

It is of paramount importance that our learners have sufficient motivation and encouragement in order toachieve their aims. We are all very proud of you, our students, and your accomplishments and lookforward to watching as you put your mark on the profession in the years ahead.

The call of the time is to progress, not merely to move ahead. Our progressive Management is lookingforward and wants our Institute to flourish as a Post Graduate Institute of Excellence. Steps are taken inthis direction and fruits of these efforts will be received by our students in the near future. Our Teachersare committed and dedicated for the development of the institution by imparting their knowledge and playthe role of facilitator as well as role model to our students.

The Pharmacy profession is thriving with a multitude of possibilities, opportunities and positivechallenges. At Guru Nanak Institute of Pharmaceutical Science and Technology, our focus is on holisticneeds of our students.

I am confident that the students of GNIPST will recognize all the possibilities, take full advantage of theopportunities and meet the challenges with purpose and determination.

Excellence in Education is not a final destination, it is a continuous walk. I welcome you to join us onthis path.

My best wishes to all.

Dr. A. Sengupta

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EDITORIAL BOARD

CHIEF EDITOR DR. ABHIJIT SENGUPTAEDITOR MS. JEENATARA BEGUMASSOCIATE EDITOR MR. DIPANJAN MANDAL

HISTORICAL ARTICLE

The First Apothecary Shops:The Arabs separated the arts of apothecary and physician,establishing in Bagdad late in the eighth century the first privatelyowned drug stores. They preserved much of the Greco-Roman

wisdom, added to it, developing with the aid of their naturalresources syrups, confections, conserves, distilled waters andalcoholic liquids. The apothecary is examining logs of sandalwoodoffered by a traveling merchant, while children indulge their tastefor sweets with stalks of sugar cane. When the Moslems sweptacross Africa, Spain and southern France, they carried with them anew pattern of Pharmacy which western Europe soon assimilated.

NEWS UPDATE

16 th October World Food Day:World Food Day is celebrated every year around the world on 16October in honor of the date of the founding of the Food andAgriculture Organization of theUnited Nations in 1945. The day iscelebrated widely by many other organisations concerned with

food security, including the World Food Programme andtheInternational Fund for Agricultural Development. The World Food Day theme for 2014 is Family Farming: Feedingthe world, caring for the earth


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http://en.wikipedia.org/wiki/Food_and_Agriculture_Organizationhttp://en.wikipedia.org/wiki/Food_and_Agriculture_Organizationhttp://en.wikipedia.org/wiki/United_Nationshttp://en.wikipedia.org/wiki/World_Food_Programmehttp://en.wikipedia.org/wiki/International_Fund_for_Agricultural_Developmenthttp://en.wikipedia.org/wiki/International_Fund_for_Agricultural_Developmenthttp://en.wikipedia.org/wiki/World_Food_Programmehttp://en.wikipedia.org/wiki/United_Nationshttp://en.wikipedia.org/wiki/Food_and_Agriculture_Organizationhttp://en.wikipedia.org/wiki/Food_and_Agriculture_Organization


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High-speed evolution in the lab: Geneticistsevaluate cost-effective genome analysis: (17 th October, 2014)Life implies change. And this holds true for genes as well.Organisms require a flexible genome in order to adapt to changesin the local environment. Researchers want to know whyindividuals differ from each other and how these differences areencoded in the DNA. In two review papers, they discuss why DNAsequencing of entire groups can be an efficient and cost-effectiveway to answer these questions.

Scientific breakthrough will help designantibiotics of the future: (17 th October, 2014)Computer simulations have been used to show how bacteria areable to destroy antibiotics -- a breakthrough which will helpdevelop drugs which can effectively tackle infections in the future.

Improving bladder function among people withspinal cord injuries: (17 th October, 2014)New research may lead to dramatically fewer bladder infections

following spinal cord injuries and other traumatic injuries --infections that can cause kidney damage, and even death, scientistsreport.

Physicists sound warning to 'nail beautyfanatics': (17 th October, 2014)The daily trimming of fingernails and toenails to make them moreaesthetically pleasing could be detrimental and potentially lead toserious nail conditions.

Cystic Fibrosis lung infection: Scientists openblack box on bacterial growth: (17 th October,2014)Researchers have shown for the first time how bacteria can growdirectly in the lungs of Cystic fibrosis patients, giving them the


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opportunity to get tremendous insights into bacteria behavior andgrowth in chronic infections.

Divide and conquer: Novel trick helps rare

pathogen infect healthy people: (17th

October,2014)New research into a rare pathogen has shown how a uniqueevolutionary trait allows it to infect even the healthiest of hoststhrough a smart solution to the body's immune response against it,scientists report.

Emergency aid for overdoses: (17 th October,

2014)Every minute counts in the event of an overdose. Now, researchershave developed an agent to filter out toxins from the body morequickly and efficiently. It can also be used for dialysis in patientssuffering from hepatic failure.

Presence of enzyme may worsen effects ofspinal cord injury and impair long-term recovery:(17 th October, 2014)Traumatic spinal cord injury (SCI) is a devastating condition withfew treatment options. Studies show that damage to the barrierseparating blood from the spinal cord can contribute to theneurologic deficits that arise secondary to the initial trauma.Through a series of experiments, researchers suggest that matrixmetalloproteinase-3 (MMP-3) plays a pivotal role in disruption ofthe brain/spinal cord barrier (BSCB), cell death, and functionaldeficits after SCI. This link also presents new therapeutic

possibilities.


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First step: From human cells to tissue-engineered esophagus: (17 th October, 2014)In a first step toward future human therapies, researchers have

shown that esophageal tissue can be grown in vivo from bothhuman and mouse cells. Cellular self-destruct program has deep roots

throughout evolution: (16 th October, 2014)In what seems like a counter-intuitive move against survival,within animals, some cells are fated to die from the triggering of anelaborate cell death program, known as apoptosis. Now,researchers have honed in on understanding the evolution ofcaspase-8, a key cell death initiator molecule that was firstidentified in humans. For detail mail to editor

KNOWLEDGE BASED ARTICLE

Hyperuricemia (High Uric Acid)

Hyperuricemia is an excess of uric acid in the blood. Uric acid passesthrough the liver, and enters your bloodstream. Most of it is excreted(removed from your body) in your urine, or passes through yourintestines to regulate "normal" levels.

Normal Uric acid levels are 2.4-6.0 mg/dL (female) and 3.4-7.0 mg/dL(male). Normal values will vary from laboratory to laboratory.

Also important to blood uric acid levels are purines. Purines arenitrogen-containing compounds, which are made inside the cells ofyour body (endogenous), or come from outside of your body, fromfoods containing purine (exogenous). Purine breaks down into uricacid. Increased levels of uric acid from excess purines may


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accumulate in your tissues, and form crystals. This may cause highuric acid levels in the blood.

Uric acid formation may occur when the blood uric acid level risesabove 7 mg/dL. Problems, such as kidney stones, and gout (collectionof uric acid crystals in the joints, especially in your toes and fingers),may occur.

Causes:

Causes of high uric acid levels (hyperuricemia) can be primary(increased uric acid levels due to purine), and secondary (high uricacid levels due to another disease or condition). Sometimes, the bodyproduces more uric acid than it is able to excrete.

Causes of high uric acid levels include:

Primary hyperuricemia Increased production of uric acid from purine Your kidneys cannot get rid of the uric acid in your blood, resulting

in high levels Secondary hyperuricemia Certain cancers, or chemotherapy agents may cause an increased

turnover rate of cell death. This is usually due to chemotherapy, buthigh uric acid levels can occur before chemotherapy is administered.

After chemotherapy, there is often a rapid amount of cellulardestruction, and tumor lysis syndrome may occur. You may be at riskfor tumor lysis syndrome if you receive chemotherapy for certaintypes of leukemia, lymphoma, or multiple myeloma, if there is a largeamount of disease present.

Kidney disease - this may cause you to not be able to clear the uricacid out of your system, thus causing hyperuricemia. Medications - can cause increased levels of uric acid in the blood Endocrine or metabolic conditions -certain forms of diabetes, or

acidosis can cause hyperuricemia


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Elevated uric acid levels may produce kidney problems, or none atall. People may live many years with elevated uric acid levels, and they do not develop gout or gouty arthritis (arthritis means "jointinflammation"). Only about 20% of people with elevated uric acid levels ever develop gout, and some people with gout do not havesignificantly elevated uric acid levels in their blood.

Symptoms:

People may not have any symptoms. If patients blood uric acid levels are significantly elevated, and

undergoing chemotherapy for leukemia or lymphoma, patient may

have symptoms kidney problems, or gouty arthritis from high uricacid levels in your blood. Patient may have fever, chills, fatigue if you have certain forms of

cancer, and your uric acid levels are elevated (caused by tumor lysissyndrome)

Inflammation of a joint (called "gout") can occour, if the uric acid crystals deposit in one of the joints. (*Note- gout may occur withnormal uric acid levels, too).

Patient may have kidney problems (caused by formation of kidneystones), or problems with urination

Foods that are high in purine include:

All organ meats (such as liver), meat extracts and gravy Yeasts, and yeast extracts (such as beer, and alcoholic beverages) Asparagus, spinach, beans, peas, lentils, oatmeal, cauliflower and

mushrooms

Foods that are low in purine include: Refined cereals - breads, pasta, flour, tapioca, cakes Milk and milk products, eggs Lettuce, tomatoes, green vegetables Cream soups without meat stock


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Water, fruit juice, carbonated drinks Peanut butter, fruits and nuts Keep well hydrated, drinking 2 to 3 liters of water per day, unless

you were told otherwise. Take all of your medications for hyperuricemia as directed Avoid caffeine and alcohol, as these can contribute to problems with

uric acid and hyperuricemia. Avoid medications, such as thiazide diuretics (hydrochlortiazide),

and loop diuretics (such as furosemide or Lasix). Also, drugs such asniacin, and low doses of aspirin (less than 3 grams per day) canaggravate uric acid levels. Do not take these medications, or aspirinunless a healthcare provider who knows your condition told you.

If you experience symptoms or side effects, especially if severe, besure to discuss them with your health care team. They can prescribemedications and/or offer other suggestions that are effective inmanaging such problems.

Treatment:

Non-steroidal anti-inflammatory (NSAID) agents and Tylenol - suchas naproxen sodium and ibuprofen may provide relief of gout-related

pain. Gout may be a result of a high uric acid level. If to avoid NSAID drugs, because of the type of cancer or

chemotherapy you are receiving, acetaminophen (Tylenol() up to4000 mg per day (two extra-strength tablets every 6 hours) mayhelp.

It is important not to exceed the recommended daily dose of Tylenol,as it may cause liver damage.

Uricosuric Drugs: These drugs work by blocking the reabsorption of urate, which can prevent uric acid crystals from being deposited intothe tissues. Examples of uricosuric drugs include probenecid, and sulfinpyrazone.

Xanthine oxidase inhibitors - Such as allopurinol, will prevent gout.However, it may cause the symptoms of gout to be worse if it istaken during an episode of painful joint inflammation.


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Allopurinol may also be given to the patients, if they have a certainform of leukemia or lymphoma, to prevent complications fromchemotherapy and tumor lysis syndrome - and not necessarily toprevent gout. With high levels of uric acid in your blood, as a resultof the disease, the uric acid will collect and form crystals in thekidneys. This may occur during chemotherapy, and may causekidneys to fail.

Jeenatara Begum

Assistant Professor

GNIPST

DISEASE RELATED BREAKING NEWS

Middle East respiratory syndrome coronavirus(MERS-CoV) Saudi Arabia: (16 th October,2014)The National IHR Focal Point of Saudi Arabia (SAU) has reportedadditional laboratory-confirmed cases of infection with MiddleEast respiratory syndrome coronavirus (MERS-CoV) to WHO. Read more

UPCOMING EVENTS 5th International Conference on Stem Cells and Cancer 2014, JNUConvention Centre, New Delhi, India from 8-10 November, 2014


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http://www.who.int/csr/don/16-october-2014-mers/en/http://d/Jeenat/Bulletin%2034.3_1/New%20Folder/UPCOMING%20EVENTS.docxhttp://d/Jeenat/Bulletin%2034.3_1/New%20Folder/UPCOMING%20EVENTS.docxhttp://www.who.int/csr/don/16-october-2014-mers/en/


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DRUGS UPDATES

FDA Approves Esbriet (pirfenidone) forIdiopathic Pulmonary Fibrosis: (15 th October,2014)The U.S. Food and Drug Administration today approved Esbriet(pirfenidone) for the treatment of idiopathic pulmonary fibrosis(IPF). Read more

CAMPUS NEWS The Cultural Programme on Bijoya Dashami and Kali Puja will be

held on 20th

October, 2014 An exhibition on Photography and Painting will be held on 20 th October, 2014 The GNIPST Cricket Tournament will be held on 21st and 22nd October, 2014. Congratulation to the winner of Football Tournament-B.Pharm3rd year, 2014

Runner up team-B.Pharm final year, 2014 Congratulation to the winner of Table Tennis Tournament-Krishnakali Basu, B.Pharm 3rd year, 20141st Runner up-Aindrila Bhowmick, B.Pharm 2nd year, 20142nd Runner up-Sayani Banerjee, B.Pharm 2nd year, 2014 The GNIPST Football Tournament (for male students) and TableTennis tournament (for female students) was held on 25th and26th September, 2014. On 5th September, 2014 the students of GNIPST have arranged awonderful Teachers Day Programme. On behalf of all the teachersof GNIPST I would like to thank our beloved students. The Freshers welcome programme was held on 14th August, 2014.Welcome 1st year students.


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http://www.drugs.com/newdrugs/fda-approves-esbriet-pirfenidone-idiopathic-pulmonary-fibrosis-4099.htmlhttp://www.drugs.com/newdrugs/fda-approves-esbriet-pirfenidone-idiopathic-pulmonary-fibrosis-4099.htmlhttp://www.drugs.com/newdrugs/fda-approves-esbriet-pirfenidone-idiopathic-pulmonary-fibrosis-4099.html


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We congratulate the following M.Pharm. final year students whohave made their positions in different pharmaceutical companies.Anirban Banerjee (Emami Ltd.)

Mahender Roy (Stadmed private Ltd.) We congratulate the following B.Pharm. final year students fortheir success.Samadrita Mukherjee (Abbott India Ltd.)Suman Sarkar (Tata Medical Centre-Apollo Pharmacy)Shrewashee Mukherjee (Fresenius Kabi-Parenteral Nutrition)Avishek Naskar (Glaxo SmithKline-Marketing)

Bappaditya Manik (USV Limited)Sarbani Das (Nutri Synapzz-Marketing)Ankita Roy (Nutri Synapzz-Marketing)Rahul Mitra (B M Pharmaceuticals-Production) The following B.Pharm. final year students have qualified, GPAT-2014. We congratulate them all.Utsha SinhaSatarupa BhattacharyaSandipan SarkarPurbali Chakraborty Reminiscence, 2014(GNIPST Reunion) was held in Collegecampus on 2nd February,2014. 1st Annual Sports of GNIPST was held on 3rd February,2014 inCollege campus ground. An industrial tour and biodiversity tour was conducted in Sikkimfor B.Pharm and B.Sc. students under the supervision of Mr. AsisBala, Ms. Jeentara Begum and Ms. Moumita Chowdhury. B.Pharm 3rd year won the GNIPST Football Champions trophy,2013. B.Pharm 3rd year won the final match 1-0 against B.Pharm 2nd year. Deep Chakraborty was the only scorer of the final.


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EDITORS NOTE

It is a great pleasure for me to publish the 2 nd issue of 38 th Volumeof GNIPST BULLETIN . All the followers of GNIPST BULLETIN

are able to avail the bulletin through facebook account GNIPSTbulletin I am very much thankful to all the GNIPST members andreaders who are giving their valuable comments, encouragementsand supports. I am also thankful to Dr. Abhijit Sengupta , Directorof GNIPST for his valuable advice and encouragement. Specialthanks to Dr. Prerona Saha, Mr. Debabrata Ghosh Dastidarand Mr. Soumya Bhattacharya for their kind co-operation and

technical supports. Thank you Mr. Soumya Bhattacharya for thequestionnaires of the student section. An important part of theimprovement of the bulletin is the contribution of the readers. Youare invited to send in your write ups, notes, critiques or any kind ofcontribution for the forthcoming special and regular issue.I wish all the GNIPST members and readers a very Happy Puja.

ARCHIVE Students of GNIPST organized pre puja celebration programme,Saaranyaon 7th October, 2013 in college Auditorium.

GNIPST organized a garment distribution programme on 28th September, 2013 at Dakshineswar Kali Temple and Adyapith,Kolkata. On this remarkable event about hundred people have

received garments. More than hundred students and most of thefaculties participated on that day with lot of enthusiasm.

GNIPST celebrated World Heart Day (29 th September) andPharmacists Day (25 th September) on 25th and 26th September,


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2013 in GNIPST Auditorium. A seminar on Violence againstwoman and female foeticide was held on GNIPST Auditorium on25th September organized by JABALA Action Research

Organization. On 26th

September an intra-college Oral and Posterpresentation competition related to World Pharmacists day andHeart day was held in GNIPST. Ms. Purbali Chakraborty ofB.Pharm 4th year won the first prize in Oral Presentation. Thewinner of Poster presentation was the group of Ms. Utsa Sinha,Mr. Koushik Saha and Mr. Niladri Banerjee (B.Pharm 4th year). Agood number of students have participated in both thecompetition with their valuable views.

Teachers day was celebrated on 5 th September, 2013 by thestudents of GNIPST in GNIPST Auditorium.

Azalea exotic flower ) , the fresher welcome programme fornewcomers of GNIPST in the session 2013-14 was held on 8th August in GNIPST Auditorium. One day seminar cum teachers development programme forschool teachers on the theme of Recent Trends of Life Sciencesin Higher Education organized by GNIPST held on 29th June,2013 at GNIPST auditorium. The programme was inaugurated byProf . Asit Guha, Director of JIS Group, Mr. U.S. Mukherjee, DyDirector of JIS Group and Dr. Abhijit Sengupta, Director cumPrincipal of GNIPST with lamp lighting. The programme started

with an opening song performed by the B.Pharm students of thisinstitute. The seminar consists of a series of lectures, videopresentations and poster session. On the pre lunch session 4lectures were given by Dr. Lopamudra Dutta, Mr. DebabrataGhosh Dastidar, Ms. Swati Nandy and Ms. Tamalika Chakraborty


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respectively. On their presentation the speakers enlighten therecent development of Pharmacy, Genetics and Microbiology andtheir correlation with Life Sciences. On the post lunch session, Ms.Saini Setua and Ms. Sanchari Bhattacharjee explained the recentdevelopment and career opportunities in Biotechnology andHospital Management. The programme was concluded withvaledictory session and certificate distribution.

About 50 Higher secondary school teachers from differentschools of Kolkata and North& South 24 Parganas district of WestBengal participated in this programme. A good interactive sessionbetween participants and speakers was observed in the seminar.The seminar was a great success with the effort of faculties, staffsand students of our Institute. It was a unique discussion platformfor school teachers and professional of the emerging and newerbranches of Life Science.

The general body meeting of APTI, Bengal Branch has beenconducted at GNIPST on 15th June, 2012. The program started witha nice presentation by Dr. Pulok Kr. Mukherjee, School of Natural

Products, JU on the skill to write a good manuscript forpublication in impact journals. It was followed by nearly two hourlong discussion among more than thirty participants on differentaspects of pharmacy education. Five nonmember participantsapplied for membership on that very day.

GNIPST is now approved by AICTE and affiliated to WBUT forconducting the two years post graduate course (M.Pharm)in PHARMACOLOGY. The approved number of seat is 18.

The number of seats in B.Pharm. has been increased from 60 to120.


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AICTE has sanctioned a release of grant under ResearchPromotion Scheme (RPS) during the financial year 2012-13toGNIPST as per the details below:

a. Beneficiary Institution: Guru Nanak Institution of PharmaceuticalScience & Technology.b. Principal Investigator: Dr. LopamudraDutta.

c. Grant-in-aid sanctioned:Rs. 16,25000/- onlyd. Approved duration:3 yearse. Title of the project: Screening and identification of potential

medicinal plant of Purulia & Bankura districts of West Bengal

with respect to diseases such as diabetes, rheumatism, Jaundice,hypertension and developing biotechnological tools for enhancingbioactive molecules in these plants.


gnipst bulletin 38.2

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