gnipst bulletin 34.4

5/23/2018 Gnipst Bulletin 34.4

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MESSAGE FROM PRINCIPAL

"It can happen. It does happen.

But it can't happen if you quit." Lauren Dane.

We are what we repeatedly do.

Excellence then is not an act, but a habit. Aristotle

It gives me immense pleasure to pen a few words for our e-bulletin. At the onset I would like to thank th

last years editors and congratulate the newly selected editors for the current year.

Our first consideration is always in the best interest of the students. Our goal is to promote academiexcellence and continuous improvement.

I believe that excellence in education is aided by creating a learning environment in which all learners ar

supported in maximizing their potential and talents. Education needs to focus on personalized learnin

and instruction, while promoting an education system that is impartial, universally accessible, and meeting

the needs of all students.

It is of paramount importance that our learners have sufficient motivation and encouragement in order to

achieve their aims. We are all very proud of you, our students, and your accomplishments and look

forward to watching as you put your mark on the profession in the years ahead.

The call of the time is to progress, not merely to move ahead. Our progressive Management is lookin

forward and wants our Institute to flourish as a Post Graduate Institute of Excellence. Steps are taken in

this direction and fruits of these efforts will be received by our students in the near future. Our Teacher

are committed and dedicated for the development of the institution by imparting their knowledge and play

the role of facilitator as well as role model to our students.

The Pharmacy profession is thriving with a multitude of possibilities, opportunities and positiv

challenges. At Guru Nanak Institute of Pharmaceutical Science and Technology, our focus is on holisti

needs of our students.

I am confident that the students of GNIPST will recognize all the possibilities, take full advantage of the

opportunities and meet the challenges with purpose and determination.

Excellence in Education is not a final destination, it is a continuous walk. I welcome you to join us o

this path.

My best wishes to all.

Dr. A. Sengupta

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EDITORIAL BOARDCHIEF EDITOR DR. ABHIJIT SENGUPTA

EDITOR MS. JEENATARA BEGUM

ASSOCIATE EDITOR MR. DIPANJAN MANDAL

HISTORICAL ARTICLE

PHARMACY: A BRIEF HISTORY OF THE

PROFESSION

By Joseph L. Fink III, B.S.Pharm, J.D.The evolution of pharmacyThe first college to train pharmacists in the U.S. was founded in1821 as the Philadelphia College of Pharmacy. Impetus for thiscame from a plan by local physicians to start training pharmacists.Local pharmacy leaders were outraged that physicians wouldpresume to be able to train pharmacists. Hence, the pharmacistswere motivated to start their own program. This institution todaystill bears the same name and is part of the University of theSciences in Philadelphia.

Boston pharmacists shortly followed (1823) with the secondcollege, the Massachusetts College of Pharmacy, now theMassachusetts College of Pharmacy and Health Sciences.Institutions in New York City, Baltimore, Chicago, and St. Louisfollowed so that by the end of the Civil War a number ofinstitutions existed, centered primarily in the Northeastern U.S.

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The first pharmacy program in a public institution came along atthe University of Michigan in the late 1860s.

The year 1862 had brought enactment of the Morrill Act through

which Congress encouraged development of land grantuniversities by giving each state 30,000 acres of public land foreach U.S. Senator and Representative from the state under the1860 census. This land was to be sold to create an endowment tosupport creation of a university teaching practical courses. Mostcollege-level instruction in the U.S. until that time emphasized theclassical fields of law, theology, and perhaps natural history. Anumber of schools of pharmacy in the U.S. are at these land-grantinstitutions.

Now we need to fast-forward to the era of World War II. Many ofthe independent colleges of pharmacy had become affiliated withuniversities over the years. Those that had not done so facedperilous financial times during the war because of being heavilydependent on tuition revenue for operations. Pharmacy studentswere overwhelmingly male at that time and when most becamesoldiers and went off to fight the war the schools fell on hard

times.At the same time, academic health centers began to emerge at U.S.universities as clusters of schools of the health professionsassembled with a university hospital operated for the dualpurposes of providing patient care and educating futureprofessionals. Many of these operations included colleges ofpharmacy.

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NEWS UPDATE

World Blood Donor Day: 14th June

The focus of this year's World Blood Donor Day campaign is "Safeblood for saving mothers". Every day, about 800 women die frompregnancy or childbirth-related complications. Severe bleedingduring delivery and after childbirth is a major cause of mortality,morbidity and long-term disability. The goal of WHOs campaignis to increase awareness about why timely access to safe blood andblood products is essential for all countries as part of acomprehensive approach to prevent maternal deaths.

Clot-busting drugs reduce deaths from

pulmonary embolism by nearly half: (17th June,

2014)Adding clot-busting medications known as thrombolytics toconventional approaches when treating sudden-onset pulmonaryembolism patients is associated with 47 percent fewer deaths than

using standard intravenous or under-the-skin anticoagulantmedications alone, a team of researchers has found, bringingclarity to a decades-long debate.

Heparin derivative suppresses neuroblastoma

tumor growth: (17thJune, 2014)A new strategy for treating neuroblastoma using a modifiedversion of heparin, a century-old injectable drug that thins the

blood to prevent clots from forming, has been discovered byresearchers. The study, conducted in mice, found that whenheparin is altered to remove its blood-thinning properties, it cansuppress and shrink neuroblastoma tumors without causingsevere bleeding.

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Gene 'switch' reverses cancer in common

childhood leukemia: (17thJune, 2014)A type of leukaemia can be successfully 'reversed' by coaxing the

cancer cells back into normal development, researchers havedemonstrated. The discovery was made using a model of B-progenitor acute lymphoblastic leukaemia, the most commoncancer affecting children. Researchers showed that switching off agene called Pax5 could cause cancer in a model of B-ALL, whilerestoring its function could 'cure' the disease.

Gut bacteria predict survival after stem cell

transplant: (17thJune, 2014)The diversity of bacteria in the gastrointestinal tract of patientsreceiving stem cell transplants may be an important predictor oftheir post-transplant survival, researchers report. Researchersfound a strong connection between post-transplant gutmicrobiota diversity and outcomes, observing overall survival ratesof 36 percent, 60 percent, and 67 percent among the low,intermediate, and high diversity groups, respectively.

Stress hormone linked to short-term memory

loss as we age, animal study suggests: (17th

June, 2014)A new study reports a potential link between stress hormones andshort-term memory loss in older adults. The study reveals thathaving high levels of cortisola natural hormone in our body

whose levels surge when we are stressedcan lead to memorylapses as we age.

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Nanoshell shields foreign enzymes used to

starve cancer cells from immune system: (17th

June, 2014)A nanoshell to protect foreign enzymes used to starve cancer cellsas part of chemotherapy has been developed by nanoengineers.Enzymes are naturally smart machines that are responsible formany complex functions and chemical reactions in biology.However, despite their huge potential, their use in medicine hasbeen limited by the immune system, which is designed to attackforeign intruders.

Vaccine reprograms pancreatic cancers to

respond to immunotherapy: (18thJune, 2014)A vaccine that triggered the growth of immune cell nodules withinpancreatic tumors, essentially reprogramming these intractablecancers and potentially making them vulnerable to immune-basedtherapies, has developed and tested by researchers. Thereprogramming is designed to make the tumors more vulnerable to

other immune-modulating drugs that have been useful in fightingother cancers, researchers explain.

Blocking brain's 'internal marijuana' may trigger

early Alzheimer's deficits: (18thJune, 2014)A new study has implicated the blocking of endocannabinoids--signaling substances that are the brain's internal versions of thepsychoactive chemicals in marijuana and hashish -- in the earlypathology of Alzheimer's disease.

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Genetic mutation causes early brain damage:

(18thJune, 2014)Scientists have shed light on how a specific kind of genetic

mutation can cause damage during early brain development thatresults in lifelong learning and behavioral disabilities. The studyfocuses on the role of a gene known as Syngap1. In humans,mutations in Syngap1 are known to cause devastating forms ofintellectual disability and epilepsy.

Race a factor in mortality in heart attack

patients on anti-clotting drug: (18thJune, 2014)The first genetic variations linked to race have been identified thatbegin to explain a higher risk of death among some AfricanAmerican and Caucasian patients taking the anti-clotting drugclopidogrel after a heart attack. In particular, the team found thattwo DNA variants common in African Americans were associatedwith an increased risk of both bleeding and death. In Caucasians, adifferent variant was linked to additional heart attacks and ahigher risk of death.

For detail mail toeditor

KNOWLEDGE BASED ARTICLE

AN ELECTRON (e-) IS RESPONSIBLE FOR

ALMOST ALL HUMAN DISEASE

An extra unpaired electron (e

-

) in the outer orbit of a molecule issome time capable of independent existence and commonly

termed as free radical. The concept of free radicals discovered in

1969 by Dr. McCord father of free-radical biology' and at the same

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mailto:[email protected]:[email protected]:[email protected]:[email protected]


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time the interest of free radical biology is growing up day by day.

Oxygen (O2) is required for the generation of the bodys first free

radical superoxide (O2) by multiple pathways through the

activation of NADPH oxidase enzyme and in tern other free

radicals like hydroxyl (OH-) radical peroxinitrite (ONOO-)

radicals are produced in human cells. Generally some important

physiological functions like tissue repair and regeneration during

acute and chronic inflammation are regulated by responsive

signaling pathway through the production of oxygen radicals.However it also plays a critical super oxidant role to cause the

oxidation of biomolecules mainly protein, amino acids, lipid and

DNA. To combat with this free radical we have different

antioxidant enzymes like superoxide dismutase, catalase and

additionally we have daily consumed dietary antioxidants. Any

physical and mental stress of the complicated modern human life

make the imbalance between free radicals and body antioxidant

defense through the over activation of NADPH oxidase and

produce the main life style diseases like hypertension, diabetes,

cancer only by the attachment of e- to O2 molecule. The over

production of O2 and other free radicals may damage the

pancreatic cells and may cause diabetes due to insulin deficiency

in human body. The damage of free fatty acid by the super oxidant

radicals may block the peripheral arteries and increased the total

peripheral resistance to produce hypertension. Ultimately the

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conversion of prooncogene to oncogene and suppression of tumor

suppressor gene by the effect of excess free radicals cause the life

threatening cancer. Thus the extra e- inO2 molecule is responsible

of almost all human disease.

Dr. Asis Bala

Asst. Prof., GNIPST

DISEASE RELATED BREAKING NEWS

Ebola virus disease, West Africa: (18thJune, 2014)

Guinea

Between 14 and 16 June 2014, a total of 7 new cases and 5 new

deaths were reported from Gueckedou (4 cases and 5 deaths) and

Boffa (3 cases and 0 deaths). This brings the cumulative number of

cases and deaths reported from Guinea to 398 (254 confirmed, 88probable and 56 suspected) and 264 deaths.

Sierra Leone


deaths were reported from Kailahun (29 cases and 4 deaths), Kono

(1 case), and Western (1 case). This brings the cumulative number

of cases and deaths reported from Sierra Leone to 97 (92

confirmed, 3 probable, and 2 suspected) and 49 deaths.

Liberia


deaths were reported from Lofa (6 cases and 0 deaths) and

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Montserrado (3 cases and 5 deaths). This brings the cumulative

number of cases and deaths reported from Liberia to 33 (18

confirmed, 8 probable, and 7 suspected) and 24 deaths.

WHO is also closely supporting the Ministries of Health inaddressing community resistance that is emerging in some areas;

deploying additional experts in the various specialities

(epidemiology, social mobilization, case management, and

logistics among others); and enhancing cross-border collaboration.

The next cross-border meeting between the three countries is

planned for 23 June 2014.Read more

UPCOMING EVENTS

5thInternational Conference on Stem Cells and Cancer 2014, JNU

Convention Centre, New Delhi,India from 8-10 November.2014

DRUGS UPDATES

FDA Approves Lymphoseek to determine the extent

of Head and Neck Cancer in the body: (13thJune,

2014)

The U.S. Food and Drug Administration approved a new use forLymphoseek (technetium 99m tilmanocept) Injection, a

radioactive diagnostic imaging agent used to help doctors fordetermination of the extent of a type of cancer called squamouscell carcinoma has spread in the bodys head and neck region. In2013, Lymphoseek was approved to help identify lymph nodesclosest to a primary tumor in patients.Read more

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CAMPUS NEWS

Reminiscence, 2014(GNIPST Reunion) was held in College

campus on 2

nd

February,2014.

1st Annual Sports of GNIPST was held on 3rd February,2014 inCollege campus ground.

An industrial tour and biodiversity tour was conducted in Sikkimfor B.Pharm and B.Sc. students under the supervision of Mr. Asis

Bala, Ms. Jeentara Begum and Ms. Moumita Chowdhury.

B.Pharm 3rd year won the GNIPST Football Champions trophy,2013. B.Pharm 3rdyear won the final match 1-0 against B.Pharm 2nd

year. Deep Chakrabortywas the only scorer of the final.

Students of GNIPST organized pre puja celebration programme,Saaranya on 7thOctober, 2013 in college Auditorium.

GNIPST organized a garment distribution programme on 28thSeptember, 2013 at Dakshineswar Kali Temple and Adyapith,

Kolkata. On this remarkable event about hundred people have

received garments. More than hundred students and most of the

faculties participated on that day with lot of enthusiasm.

GNIPST celebrated World Heart Day (29th

September) andPharmacists Day (25thSeptember)on 25thand 26thSeptember,

2013 in GNIPST Auditorium. A seminar on Violence against

woman and female foeticide was held on GNIPST Auditorium on

25th September organized by JABALA Action Research

Organization. On 26thSeptember an intra-college Oral and Poster

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presentation competition related to World Pharmacists day and

Heart day was held in GNIPST. Ms. Purbali Chakraborty of

B.Pharm 4th year won the first prize in Oral Presentation. The

winner of Poster presentation was the group of Ms. Utsa Sinha,Mr. Koushik Saha and Mr. Niladri Banerjee(B.Pharm 4thyear).

A good number of students have participated in both the

competition with their valuable views.

STUDENTS SECTION

WHO CAN ANSWER FIRST????

Which football match is also known as Battle ofNuremberg and why?

Which fruit was initially known as Peruvian

apple?

Answer of Previous Issues QuestionsA) G V Prasad B)WockhardtIdentify the footballer

Answer of Previous Issues ImageMargaret Chan

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Send your thoughts/Quiz/Puzzles/games/write-ups or any othercontributions for Studen ts Section answ ersof this Section at [email protected]

EDITORS NOTE

I am proud to publish the 4th

issue of 34th

Volume of GNIPST

BULLETIN. GNIPST BULLETIN now connected globally

throughfacebook account GNIPST bulletinI want to convey my thanks to all the GNIPST members and the

readers for their valuable comments, encouragement and supports.

I am thankful to Dr. Abhijit Sengupta, Director of GNIPST for

his valuable advice and encouragement. Special thanks to Dr.

Prerona Saha, Mr. Debabrata Ghosh Dastidar for their kind co-

operation and technical supports. An important part of the

improvement of the bulletin is the contribution of the readers. Youare invited to send in your write ups, notes, critiques or any kind of

contribution for the forthcoming special and regular issue.

ARCHIVE

Teachers daywas celebrated on 5thSeptember, 2013 by the

students of GNIPST in GNIPST Auditorium.

A zalea exotic flower ) , the fresher welcome programme fornewcomers of GNIPST in the session 2013-14 was held on 8th

August in GNIPST Auditorium.

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One day seminar cum teachers development programme forschool teachers on the theme of Recent Trends of Life Sciences

in Higher Education organized by GNIPST held on 29th June,

2013 at GNIPST auditorium. The programme was inaugurated byProf . Asit Guha, Director of JIS Group, Mr. U.S. Mukherjee, Dy

Director of JIS Group and Dr. Abhijit Sengupta, Director cum

Principal of GNIPST with lamp lighting. The programme started

with an opening song performed by the B.Pharm students of this

institute. The seminar consists of a series of lectures, video

presentations and poster session. On the pre lunch session 4

lectures were given by Dr. Lopamudra Dutta, Mr. Debabrata

Ghosh Dastidar, Ms. Swati Nandy and Ms. Tamalika Chakraborty

respectively. On their presentation the speakers enlighten the

recent development of Pharmacy, Genetics and Microbiology and

their correlation with Life Sciences. On the post lunch session, Ms.

Saini Setua and Ms. Sanchari Bhattacharjee explained the recent

development and career opportunities in Biotechnology and

Hospital Management. The programme was concluded with

valedictory session and certificate distribution.About 50 Higher secondary school teachers from different

schools of Kolkata and North& South 24 Parganas district of

West Bengal participated in this programme. A good interactive

session between participants and speakers was observed in the

seminar. The seminar was a great success with the effort of

faculties, staffs and students of our Institute. It was a unique

discussion platform for school teachers and professional of theemerging and newer branches of Life Science.

The general body meeting of APTI, Bengal Branch has been

conducted at GNIPST on 15th June, 2012. The program started

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with a nice presentation by Dr. Pulok Kr. Mukherjee, School of

Natural Products, JU on the skill to write a good manuscript for

publication in impact journals. It was followed by nearly two hour

long discussion among more than thirty participants on differentaspects of pharmacy education. Five nonmember participants

applied for membership on that very day.

GNIPST is now approved by AICTE and affiliated to WBUT for

conducting the two years post graduate course (M.Pharm) in

P H A R M A C O L O G Y .The approved number of seat is 18.The number of seats in B.Pharm. has been increased from 60 to

120.

AICTE has sanctioned a release of grant under Research

Promotion Scheme (RPS) during the financial year 2012-13to

GNIPST as per the details below:

a. Beneficiary Institution:Guru Nanak Institution of Pharmaceutical

Science & Technology.

b.Principal Investigator:Dr. LopamudraDutta.c. Grant-in-aid sanctioned:Rs. 16,25000/- only

d.Approved duration: 3 years

e. Title of the project: Screening and identification of potential

medicinal plant of Purulia & Bankura districts of West Bengal

with respect to diseases such as diabetes, rheumatism, Jaundice,

hypertension and developing biotechnological tools for enhancing

bioactive molecules in these plants.

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gnipst bulletin 34.4

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