t. pallidum par sa sensibilite et sa specificit6. kellogg

RErTER TREPONEME: A REVIEW OF THE L1TERATURE 85

T. pallidum par sa sensibilite et sa specificit6. Kellogg& Deacon (1964) ont decouvert une nouvelle tech-nique qui permet l'identification rapide de T. palli-dum. Lamedica & Robert (1957) ont appliqu6 lam6thode de l'hemagglutination A l'etude des anti-corps contre 1'antigene obtenu a partir du tr6po-n6me de Reiter. Giannettasio (195la-b) a utilise,pour des tests intradermiques, des cryolysats de tre-ponemes de Reiter prepares selon la methode deD'Alessandro.

Reiter (1926a) rapporte que Sagel avait considera-blement ameliore I'etat clinique de sujets atteints deparesie en leur injectant un vaccin vivant obtenu Apartir du tr6poneme de Reiter. Miller et al. (1960,1963) et Carpenter et al. (1960) ont immunise deslapins par I'antig6ne proteique de Reiter; cependantapres inoculation de T. pallidum, ils n'ont observ6aucune protection due A I'antigene proteinique.

Meinicke (1956a) a constat6 que l'immunisation delapins par le treponeme de Reiter tue ne produisaitpas d'anticorps specifiques contre T. pallidum, bienque l'immunisation par T. pallidum ait amene laformation d'anticorps vis-a-vis du treponeme deReiter.

Faisant le point en matiere de recherche, Curtis(1964) note que les insuffisances des tests treponemi-ques et l'incapacite actuelle de definir une methodepratique d'immunisation n'ont pu etre vaincues enraison de l'ignorance entourant la structure anti-genique des treponemes et le role des divers anticorpschez 1'hote. Cependant, on a isole, a partir du tr6po-neme de Reiter, diverses fractions, polysaccharidi-que, proteique et lipidiques, et on a pu extraire cer-taines fractions antigeniques a partir d'organismespathogenes. On est en droit d'esperer que ces travauxconduiront "a des tests treponemiques plus precis.

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Hunter, E. F., Deacon, W. E. & Meyer, P. E. (1964)An improved FTA test for syphilis, the absorptionprocedure (FTA-ABS). Publ. Hlth Rep. (Wash.), 79,410-412

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Jeney, E., &soka, I. & Biro, L. (1957a) Bedeutung derPallida-Reaktion in der Diagnostik der Syphilis.Hautarzt, 8, 322-323

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Kagan, G. Ja. & Levashev, V. S. (1961) [On the L-formingactivity of certain antibiotics in experimental conditionsin vitro]. Antibiotiki, 6, 383-385

Kanof, N. B. (1959) False positive reactions in serologictests for syphilis. The interpretation of specific trepo-nemal tests. Proc. Rudolf Virchow med. Soc. ScientificSessions, 18, 53-57

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Keller, R. & Morton, H. E. (1952) The effect of a handsoap and a hexachlorophene soap on the cultivatabletreponemata. Amer. J. Syph., 36, 524-527

Keller, R. & Morton, H. E. (1953) Susceptibility ofKazan, Nichols, and Reiter strains of treponema andPPLO organisms to the antibiotic erythromycin(ilotycin). Amer. J. Syph., 37, 379-382

Kellogg, D. S., Jr & Deacon, W. E. (1964) A new rapidimmunofluorescent staining technique for identifica-tion of Treponema pallidum and Neisseria gonorrhoeae.Proc. Soc. exp. Biol. (N.Y.), 115, 963-965

Kent, J. F., Covert, S. V., Reilly, H. W., Kinch, W. H. &Lawson, W. B. (1962) Evaluation of fluorescent trepo-nemal antibody (RFTA and FTA II) and other tests(RPCF and TPI) for syphilis. Proc. Soc. exp. Biol.(N.Y.), 109, 584-589

Kent, J. F., DeWeerdt, J. B., Lawson, W. B. & Kinch,W. H. (1964a) Course of the serologic reactions inrabbits inoculated with different numbers of Treponemapallidum. Amer. J. clin. Path., 42, 33-36

Kent, J. F., De Weerdt, J. B., Lawson, W. B. & Kinch,W. H. (1964b) Course of the serologic reactions inrabbits inoculated with different numbers of Treponemapallidum. In: New York State Department of Health,Annual report of the Division of Laboratories andResearch for 1963, Albany, pp. 77-78

Kent, J. F., De Weerdt, J. B., Lawson, W. B. & Kinch,W. H. (1964c) Treponemal antibodies in bovine andporcine sera. In: New York State Department ofHealth, Annual Report of the Division of Laboratoriesand Research for 1963, Albany, pp. 78-79

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Khan, A. S., Nelson, R. A., Jr & Turner, T. B. (1951)Immunological relationship among species and strainsof virulent treponemes as determined with the Trepo-nema pallidum immobilization (TPI) test. Amer. J.Hyg., 53, 296-316

Kiraly, K. (1959) [Complement-fixation tests for syphiliscarried out with Treponema pallidum antigens. I. Anti-gen made up from pathogenic treponemes treated withultrasound]. Bdrgyogy. vener. Szle., 35, 261-271

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Kiraly, K. (1960b) Syphilis komplement-kotesi reakcioktreponema-antigenekkel. II. Reiter-treponemabol kes-zult protein antigen. Orv. Hetil., 101, 1158-1161

Kiraly, K., Jobbagy, A. & Mecher, T. (1965) Fluorescenttreponemal antibody testing. Bull. Wld Hlth Org., 33,687-703

Kjellander, J., Sievers, 0. & Vogelsang, T. M. (1959) TheReiter protein complement-fixation test for syphiliscompared with the Treponema pallidum immobilizationtest in a selected material. Acta. Path. microbiol.scand., 47, 373-379

Kjellander, J., Sievers, 0. & Vogelsang, T. M. (1961) TheReiter protein complement-fixation test for syphilis(RPCF) compared with the Treponema pallidumimmobilization test (TPI) in a selected material.Acta. path. microbiol. scand., 51, Suppl. 144, pp. 269-270

Kjellander, J., Sievers, 0. & Vogelsang, T. M. (1962)A further comparison between the Reiter proteincomplement-fixation test (RPCF) and the Treponemapallidum immobilization test (TPI). Acta. path.microbiol. scand., 56, 415-520

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Klopstock, F. (1927) Experimentelle Untersuchungen zurEntstehung der syphilitischen Blutveranderung. Klin.Wschr., 6, 685-689

Knight, A. & Wilkinson, R. D. (1963) The clinicalsignificance of the biologic false positive serologicreactor: a study of 113 cases. Canad. med. Ass. J., 88,1193-1195

Knox, J. M. & Moore, M. B., Jr (1961) Biologic falsepositive reactions for syphilis. Sth. med. J. (Bgham,Ala.), 54, 281-283

Koch, F. (1940) Vergleichende Untersuchungen anKulturen von Spirochaete pallida und saprophytischenGenitalspirochaten (Jahnel). Zbl. Bakt., L Abt. Orig.,145, 338-340

Kolmer, J. A. (1942a) Comparison of tissue and spiro-chetal antigens in complement-fixation tests (Eagle andKolmer) based upon results observed in WashingtonSerologic Survey. Amer. J. clin. Path., 12, 480-487

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I IRTREPONEME: A REVIEW OF THE LITERATURE 95

Kolmer, J. A. (1942c) Value of complement-fixation andagglutination with spirochetal antigens and relation ofspirochetal antibodies to Wassermann reagin. Arch.Derm. Syph. (Chicago), 45, 455-477

Kolmer, J. A., Kast, C. C. & Lynch, E. R. (1941a)Studies on the role of Spirochaeta pallida in the Wasser-mann reaction. I. Complement-fixation in syphilis,leprosy, and malaria with spirochetal antigens. Amer.J. Syph., 25, 300-318

Kolmer, J. A., Kast, C. C. & Lynch, E. R. (1941b)Studies on the role of Spirochaeta pallida in the Wasser-mann reaction. II. The relation of spirochetal anti-bodics to the Wassermann reagin. Amer. J. Syph., 25,412-434

Kostant, G. H. (1958) Treponemal tests in the sero-diagnosis of syphilis. J. med. Soc. N.J., 55, 608-611

Kostant, G. H. & Kelcec, L. C. (1958) An effectivesimplified serologic test for syphilis employing Reiterprotein. A.M.A. Arch. Derm., 78, 181-185

Kostant, G. H., Landy, S. E. & Kelcec, L. C. (1961)Long-term serologic studies with treponemal pro-cedures. Arch. Derm., 84, 310-312

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Kro6, H. & Schultze, F. 0. (1928) Untersuchungen fiberdie Immunitatsvorgange bei Syphilis. I. Spirochaten-spezifische Antikorper beim Menschen. Klin. Wschr., 7,246-248

Kro6, H. & Schultze, F. 0. (1929) Untersuchungen uiberdie Immunitatsvorg&inge bei Syphilis. III. Stamm-spezifische Komplementbindung und Schutzkorper.Klin. Wschr., 8, 1203-1206

Labouche, F., Nicolas, J. J. & Fritz, A. (1964) R6flexionsa propos d'un cas de syphilis cong6nitale pr6coce.Presse mnd., 72, 99-100

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Lancet, 1926, 1, 882 (Annotations-Berlin: Cultivationof Spirochaeta pallida)

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LeFever, J., Grenier, E. M. & Wheeler, A. H. (1961)Evaluation of RPCF antigen prepared by a simplifiedprocedure. In: Twelfth Annual Symposium on RecentAdvances in the Study of Venereal Diseases. Digest ofProceedings, Paper 8, Atlanta, Ga., United StatesPublic Health Service

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Lo Monaco, G. B. & Berdondini, I. (1963) Considera-zioni sui risultati di un triennio (1959-1961) di indaginisierologiche per l'accertamento della lue in variecategorie della popolazione di Firenze. Ann. Sclavo,5, 52-68

Luba§evskaja, L. N. (1961) [The value of the Wasser-mann reaction with sound-treated antigen and Reiter'sprotein fraction of the spirochaete in seroresistantsyphilis]. Vestn. Derm. Vener., 7, 61-65

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McLeod, C. P. & Garson, W. (1962) Four studies onTPCF antigen. IV. Relationship of TPCF antibody tothree other antibodies in syphilitic serum. Publ. HlthRep. (Wash.), 77, 446-451

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Manson, R. C. & Trice, E. R. (1963) The changing patternof syphilis. 5th. med. J. (Bgham, Ala.), 56, 705-710

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Medina, R. (1964) El c4rate en Venezuela. Estudio de laenfermedad en el medio natural y resultado de losensayos de inoculaci6n experimental. Derm. venez., 3,160-230

Medina, R., Briceflo Iragorri, L. & Gil Izaguire, A. (1961)La reacci6n de desviaci6n del complemento conextracto proteico de treponemas (cepa Reiter) en eldiagn6stico de las treponematosis humanas. Rev.Sanid. Asist. soc., 26, 556-561

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