dna methylation map of human atherosclerosis

Ramírez-Ruz, Antonio Gomez, Isabel Gonçalves, Sebastian Moran and Manel EstellerSilvio Zaina, Holger Heyn, F. Javier Carmona, Nuray Varol, Sergi Sayols, Enric Condom, José

A DNA Methylation Map of Human Atherosclerosis

Print ISSN: 1942-325X. Online ISSN: 1942-3268 Copyright © 2014 American Heart Association, Inc. All rights reserved.

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DOI: 10.1161/CIRCGENETICS.113.000441

1

A DNA Methylation Map of Human Atherosclerosis

Running title: Zaina et al.; DNA methylation profile of atherosclerosis

Silvio Zaina, PhD1; Holger Heyn, PhD2; F. Javier Carmona, PhD2; Nuray Varol, MSc2;

Sergi Sayols, PhD2; Enric Condom, MD3,4; José Ramírez-Ruz, MD5; Antonio Gomez, PhD2;

Isabel Gonçalves, PhD6; Sebastian Moran, PhD2; Manel Esteller, MD, PhD2,7,8

1Department of Medical Sciences, Division of Health Sciences, León Campus, University of Guanajuato, León, Guanajuato, Mexico; 2Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical

Research Institute (IDIBELL), L’Hospitalet de Llobregat; 3Department of Pathology, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL); 4Department of Pathology and

Experimental Therapeutics, 5Department of Anatomy and Pathology, Hospital Clinic, 7Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain;

6Experimental Cardiovascular Research, Lund University, Malmö, Sweden; 8Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain

Correspondence:

Manel Esteller, MD, PhD Silvio Zaina, PhD

Cancer Epigenetics & Biology Program (PEBC) Department of Medical Sciences

Bellvitge Biomedical Research Inst. (IDIBELL) Division of Health Sciences

Avda. Gran Via s7n Km 2.7 León Campus, University of Guanajuato

08908 L’Hospitalet de Llobregat 20 de Enero No. 929, Col. Obregón

Barcelona, Catalonia, 37000 León, Guanajuato

Spain Mexico

Tel: 34-93-2607253 Tel: 52-477-7143812

Fax: 34-93-2607219 Fax: 52-477-716 83 54

E-mail: [email protected] E-mail: [email protected]

Journal Subject Code: [141] Functional genomics, [143] Gene regulation

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2

Abstract

Background – Epigenetic alterations may contribute to the development of atherosclerosis. In

particular, DNA methylation, a reversible and highly regulated DNA modification, could

influence disease onset and progression since it functions as an effector for environmental

influences, including diet and lifestyle, both of which are risk factors for cardiovascular diseases.

Methods and Results – To address the role of DNA methylation changes in atherosclerosis, we

compared a donor-matched healthy and atherosclerotic human aorta sample using whole-genome

shotgun bisulfite sequencing. We observed that the atherosclerotic portion of the aorta was

hypermethylated across many genomic loci in comparison with the matched healthy counterpart.

Furthermore, we defined specific loci of differential DNA methylation using a set of donor-

matched aortic samples and a high-density (>450,000 CpG sites) DNA methylation microarray.

The functional importance in the disease was corroborated by crossing the DNA methylation

signature with the corresponding expression data of the same samples. Among the differentially

methylated CpGs associated with atherosclerosis onset, we identified genes participating in

endothelial and smooth muscle functions. These findings provide new clues towards a better

understanding of the molecular mechanisms of atherosclerosis.

Conclusions - Our data identify an atherosclerosis-specific DNA methylation profile that

highlights the contribution of different genes and pathways to the disorder. Interestingly, the

observed gain of DNA methylation in the atherosclerotic lesions justifies efforts to develop DNA

demethylating agents for therapeutic benefit.

Key words: epigenetics, DNA Methylation, genome-wide analysis, aorta

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with the corre ondi e ression data of the same samples. Amon the different

CpGs associated with atherosclerosis onset, we identified genes participating in

and smooth muscle functions. These findings provide new clues towards a bette

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3

Introduction

All cells and tissues in an organism share the same DNA sequence but can develop very different

functions. This conundrum was partially explained by epigenetics1, which represents a molecular

information party independent of the genetic code. Epigenetics creates cell-specific phenotypes

through the control of gene expression in a potentially heritable manner. The understanding of

epigenetic alterations associated with human diseases is rapidly increasing due to the

development of genome-wide technologies2,3. Epigenetic profiling has begun to be of clinical

value in cancer4 and is likely to be applied to other pathologies such as neurological5 and

cardiovascular disorders6-8, an example being the altered epigenomic patterns observed in human

end-stage cardiomyopathy9.

As for atherosclerosis, its clinical complications will continue to represent a leading

cause of death and disability worldwide in the next two decades10, implying that further research

is necessary to unravel the molecular basis of cardiovascular diseases. Using recent technology

and characterizing a broad spectrum of alterations occurring in atherosclerosis, high-throughput

screening methods have so far been used in genome-wide association studies (GWAS) to focus

on inter-individual variation and genetic aberrations occurring in diseased tissue. However,

relatively little attention has been paid to epigenetic alterations. Genetic predisposition is a

significant factor in atherosclerosis, but the GWAS studies suggest that only about 10% of cases

of cardiovascular disease have a heritable component11,12. Therefore, identifying the molecular

mechanisms of non-genetic cardiovascular risk factors is a crucial and only partially achieved

task in the field. Atherosclerosis is a multifactorial disease associated with dietary,

environmental and lifestyle risk factors. The most widely studied epigenetic mark, DNA

methylation, is a flexible regulatory modification influenced by environmental and external

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teri ing a broad spectr m of alterations occ rring in atherosclerosis high thro g

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4

factors, which partially overlap with known atherosclerosis non-genetic risk factors and is

therefore potentially involved in the onset and progression of atherosclerosis. DNA methylation

is a covalent modification of the DNA sequence with impact on gene expression and genomic

stability13. DNA methylation affects transcription in a context-dependent way, wherein promoter

hypermethylation mainly presents a repressive mark. However, differential DNA methylation in

gene bodies and intergenic loci presents more complex mechanistic implications, as it is thought

to promote transcriptional elongation and to regulate gene splicing and enhancer activities. The

detection of DNA methylation alterations could be a promising tool for cardiovascular risk

prediction and diagnosis. Although DNA methylation alterations have been described at a few

loci in atherosclerosis14,15, advances in epigenomics have allowed genome-wide studies in

addition to single-locus approaches. Examples are next-generation sequencing and high-density

array-based techniques, which reveal DNA methylation events at base-pair resolution and with

very thorough coverage in regulatory regions3. These technologies led to the identification of

significant changes in DNA methylation in various diseases, such as cancer16,17, arthritis18 and

diabetes19, and in physiological contexts, such as human aging20.

Accordingly, this study aims to transfer atherosclerosis research from epigenetic single-

loci studies to comprehensive epigenomic analysis by assessing disease-associated changes in an

unbiased manner. We hypothesize that alterations in the DNA methylation landscape are

implicated in atherosclerosis onset and progression. Herein, we present the first genome-wide

DNA methylation profiles of human donor-matched atherosclerotic aortic tissue pairs, acquired

by exploiting whole genome shotgun bisulfite sequencing21. Furthermore, we complemented the

whole genome sequencing analysis by probing a larger aortic sample with a high-coverage DNA

methylation microarray22 that determines the methylation status of more than 450,000 CpG sites

or cardiovascular rrrrisisisiskk k

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5

in the human genome.

Methods

Human Vascular Samples

Post mortem donor-matched atherosclerotic and non-atherosclerotic portions of human aortas

(referred to as "donor-matched sample pairs") were obtained at the Bellvitge Hospital and the

Clinic Hospital in Barcelona according to a protocol approved by the local ethical committee

(authorization no. PR311/11). Post-mortem time was between 3 and 26 h. Atherosclerotic and

normal (A and N, respectively) portions were macroscopically identified by a trained Pathology

Technician. Approximately 3-cm long segments of each portion were transferred to RNAlater

(Ambion) and refrigerated. A fragment was obtained from the middle portion of each segment

(either A or N) and the severity of its histological atherosclerosis was scored on the AHA scale

by a qualified Pathologist. The remaining samples were transferred to -80ºC within 1 day of

dissection. Stable, advanced (fibroatheroma or higher severity) carotid plaque samples were

obtained by endarterectomy at Malmö General Hospital, Lund University, Malmö, Sweden.

Atherosclerotic lesions and the underlying media (aortas) or the mere lesion (carotids) were used

in all the procedures described here. The relevant donor (age, sex) and sample information for

aortic and carotid specimens is shown in Supplementary Table 1.

Whole Genome Bisulfite Sequencing (WGBS) and DNA Methylation Microarray Analyses

Genomic DNA was extracted by a conventional proteinase K (Roche) and

phenol/chloroform/isoamyl alcohol (Sigma)-based protocol. For WGBS, 10 g of genomic DNA

were processed according to established protocols20. Sequencing quality was assessed using the

Illumina Sequencing Analysis Viewer and the FastQC software. We ensured that the raw reads

used in further analysis were within the standard parameters set by the Illumina protocol.

ied bbby y y y a a a a trtrtrtraiaiaiainenenened ddd PaPaPaPaththththoooo

. Approximately 3 cm long segments of each portion were transferred to RNAla

and refri rated. A fra ent was obtained from the middle ortion of each s m

r

i o

Stable, advanced (fibroatheroma or higher severity) carotid plaque samples wer

. Apprprp oxoxoximmimatelelly yyy 3-cm long segments of eaeach portion were e trtt ansferred to RNAla

anndn refrigerateted.d.d. AAA ffffrarragmgmgmeentttt wwasss obobbtatattaiinedd froom m thththhee mmmiddddddlelelel ppporrtititiiooon ooof f ff eaeaachchchch sssegegegm

r NNN))) ) ananannddd d thththhe eee seseseveveveveririritytytyy ooof itititits s s hihihihiststss ollllogogogo icicicicalalal aaaaththththerererrosososo clclclclererererososossisss wwwwasasasa sssscococc rerereeddd d onononn thehehee AAAAHAHAHAH s

ied Pathologist. ThThThThe eee rereemamamam ininnninininingg g sasasasampmpmpmplelelel ss ss wewewerererere ttransnsnsn fefefeferrrrrrrrededd ttttoo o -8-8-8- 0º0º0ºCCCC wiww thin 1 day o

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6

Positional quality along the reads was checked to be QC>30, and we excluded biases towards

specific motifs or GC enriched regions in the PCR amplification or hybridization. The filtered

reads were aligned to the reference genome HG19 using the software Bismark and Bowtie and

the DNA methylation level of individual CpG sites was calculated after discarding multiple

mapping reads. Only CpG sites containing 5 or more reads in both the normal and atherosclerotic

sample were eligible for further analysis. CpG island (CGI) mapping of WGBS data was done

according to the annotation provided by the Ontario Cancer Institute Genomics Centre. In DMR

analysis, promoters were defined as regions between positions -1,500 and +500, relative to the

transcription start sites (TSSs).

The microarray-based DNA methylation analysis was conducted with the Infinium

HumanMethylation450 BeadChip (450k array). DNA quality checks, bisulfite modification,

hybridization, data normalization, statistical filtering and Beta value calculation were carried out

as described elsewhere20,22. The methylation level for each cytosine was expressed as a Beta

value calculated as the fluorescence intensity ratio of the methylated to unmethylated versions of

the probes. Beta values ranged between 0 (unmethylated) and 1 (methylated). Of the 485,577

probes present in the microarray, 477,635 (98.4%) were successfully hybridized in all 49

individual samples (15 A and 15 N donor-paired aortic samples, 19 carotid samples). This

corresponds to an average successful hybridization of >99.9% per individual sample. The

annotation relating to CGIs uses the following categorization: "shore", each of the 2 kb-

sequences flanking a CGI; "shelf", each of the 2 kb-sequences next to a shore; "open sea", DNA

not included in any of the previous sequences or in CGIs22. TSS200 orTSS1500 indicate the

region between position -200 bp or -1,500 bp from the Transcription Start Site (TSS),

respectively. When a cytosine mapped to different genic elements due to the presence of multiple

and +500, relativeeee tototot

e

t lation450 BeadCh 450k array DNA quality checks, bisulfite modification

on, data normalization, statistical filtering and Beta value calculation were carrie

d t

lated as the fl orescence intensit ratio of the meth lated to nmeth lated ersio

e miiicrcrcroaoaoarrrrrrayayay-bababaasssed DNA methylation annnalalaa yysis was conducttctedeee with the Infinium

thhyh lllation450 BeBeBeadChChChhip ((((4454 0kkkk arrrrraay). DDNAA quaualiiitytytyty chhheccks, bbbisululullfite mmmmodddifffficaaatiiioi n

on, ddddatatattaaaa nnnon rmmalalliiizizatattiioion,n statatatiititissticallll fffililililteeee iiringngng aandndd BBBBetettaaa vaaaluululue e cacalllclcullllatatatatioioion wewerere ccararrrie

d elsewhere20,22222. ThThThhe methhhylyllation llel velll fffof r each cytyty osinii e was exprpp essed as a Bet

lllat ded hth flfl iint isit atiio fof thhe ethh llatedd to ethh llatedd iio




7

alternative transcripts, all mapping variants were counted. Functional gene annotation was

performed with the DAVID database (http://david.abcc.ncifcrf.gov). Clustering was performed

by Ward's hierarchical clustering method, using simultaneously samples and CpGs.

Pyrosequencing and Quantitative Real-Time PCR for Candidate Genes

Pyrosequencing was performed with a Pyromark Q96 (Qiagen) as previously described20.

Expression could be measured in only five post mortem aortic samples because of the difficulty

of obtaining high-quality RNA from these tissues. Quantitative real-time PCR (qRT-PCR) was

performed in triplicate as previously described20. The list of primers used for the pyrosequencing

methylation and qRT-PCR analyses is shown in Supplementary Table 2. A schematic flowchart

showing the source of the samples and the techniques used is shown in Figure 1.

Statistical analysis

In the case of 450k arrays, Beta values were converted to M values by a Logit transformation23.

M values were compared using a paired (intra-aortic pair comparison) or unpaired (comparison

between N aortic samples and atherosclerotic carotid samples) t-test. The significance threshold

in M value comparisons was a Bonferroni-corrected p<1x10-7, corresponding to an uncorrected

p<0.05. To compare all other continuous variables, either an unpaired t-test or an ANOVA with

post-hoc analysis were used as specified in each case. Frequencies were compared by using the

chi-square test. All tests were performed using the STATISTICA software.

Results

DNA Methylomes of Atherosclerotic and Normal Aortic Tissue at Single-Nucleotide

Resolution

Whole-genome shotgun bisulfite sequencing (WGBS) was used to obtain an unbiased insight

into the epigenetic alterations in atherosclerotic aortas. In particular, we profiled the DNA

sed for the pyroseqeqqqueuuu

2. A AAA schhhhematitititic flflflflowowowowc

e

a

o

w r

aortic samples and atherosclerotic carotid samples) t test The significance thres

e sooourururcecece oofff f tht ee sssamples and the techniquuueees used is shown iiinn n Figure 1.

aaanaaaalysis

of 444450505050kk kk aaarraysys, BeBeBB ttata valueueuessss were cccononononvvertrtt dededd to oo MMMM vavavaluuesseses bbbby aa Logiggigit tt ttttrann ffsfsforormamatitt o

were compppared using gg a papp iiri eddd (((intra-aortiiic ppp iiaiir compapp riiison)n) or unpapp ired ((comppparr

rtiic lpl dnd hth lcl otiic otidid lpl )) t t t ThTh isi ififiic hth s




8

methylation landscape of a grade VII atherosclerotic lesion (93A) and its adjacent unaffected

normal (93N) aortic tissue obtained from a female donor (Figure 2A-C). The rationale for

choosing that particular aortic pair was that any atherosclerosis-related DNA methylation profile

would be readily detectable if the intra-pair histological divergence was high. The analysis of

matched tissue from the same patient avoids confounding effects of the genetic background,

previously described as methylation quantitative trait loci24. The complete DNA methylation

sequence at the single nucleotide resolution is freely available at the Gene Expression Omnibus

database:

http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?token=zfephwswcyoeotw&acc=GSE46401.

We generated 774,341,172 and 877,722,420 reads for 93A and 93N, respectively. Of

these, 603,788,981 (93A) and 634,123,759 (93N) reads mapped uniquely to the reference

genome HG19, corresponding to mapping efficiencies of 77.8% (93A) and 72.2% (93N).

Genome-wide, we achieved an average 12.5-fold (93A) and 17.9-fold (93N) coverage, enabling

us to analyze 93.9% (93A) and 86.1% (93N) of all CpGs present in the reference genome.

Technically, we found that the DNA methylation levels obtained by the WGBS approach

were highly correlated with those obtained from a DNA methylation array platform (r>0.92,

Infinium HumanMethylation450 BeadChip, see below) for the 372,979 (93A) and 364,271 (93N)

CpGs interrogated by the two techniques.

Genome-wide, the atherosclerotic lesion (93A) contained more highly methylated CpGs

than the matched normal tissue. A Circos representation of average methylation levels for variant

CpGs in the 93A sample relative to the 93N sample is shown in Figure 2D. In particular, 93A

harbored 35.16M highly methylated CpG sites (>50% methylation), 17.3% more than 93N

(29.95M), and the average CpG methylation level was higher in 93A than in 93N DNA (Figure

2E,F). This pattern was consistent across all chromosomes and genomic features. The examples

eotw&&&acc=GSGSGSE4EE46464640001

generated 774,341,172 and 877,722,420 reads for 93A and 93N, respectively. O

7

G

i b

ze 93.9% (93A) and 86.1% (93N) of all CpGs present in the reference genome.

generaarateteted 7777 4,4,4,343 1,172 and 877,722,420 rereads for 93A and d d 93N, respectively. O

7888888,981 (93A)A)A) aaandndnd 666634343434,111123232 ,7,7,7,75959599 (93933N)N)NN reaadds mmappppeped dd uuniqiqiqqueeuelyyy ttttooo ththhhe e e rerer fefefefererer ncncnceee

G19,9,9,9, cccorororo rererer spspspspononondidididingngng ttttoooo mamamamapppppppininining efefefe fififiicicicicienenenciciciciessss oooof ff 77777777.8.8.8% % % % (9(9(993A3A3A3A))) ananaa dd d d 7272772.2.2.2.2% % % (9(9(9(93N3N3NN).).).

ide, we achieveeeedd dd ananann aaveveveverarragegegege 1112.2.2.2 5555-f-f-f-folololold dd (9(9(9( 3A3A3AA))) and ddd 1717177.9.9.99-f-ffololololdd d (9(9(9( 3N3N3NN))) ) coverage, enab

zzzee 9393.9.9%% (9(993A3A3A))) anand dd 86866.1.1%% (9(9(93NN3N)) ofoff aalllll CCCpGpGGss prpresesenent tt inin ttthehe rrefeffererenencece ggenenomome.e.




9

of chromosomes 15 and 20 are shown in Figure 2G.

Identification of Differentially Methylated Regions (DMRs)

Once we had identified the existence of a genome-wide aberrant DNA methylation pattern in the

atherosclerotic lesion, we sought to define genome-wide tendencies of differential methylation

regions (DMRs) between 93A and 93N. We interrogated the non-repetitive part of the genome

for regions containing at least five consecutive and consistently differentially methylated CpGs

and in which DNA methylation levels of the flanking CpG sites differed significantly between

the two samples (Fisher’s exact test, p<0.05). We identified 54,625 DMRs genome-wide, with an

average size of 615 bp and containing an average of 11 informative CpGs. Consistent with the

features observed at the genome-wide level, DMRs were mostly hypermethylated in the

atherosclerotic lesion (93A) (Figure 3A). Both promoter-related DMRs (706, corresponding to

630 genes), and intragenic DMRs (7,378, corresponding to 2,304 genes), were largely

hypermethylated in 93A and mapped predominantly to CG-poor regions (Figure 3B).

Hypermethylated DMRs in 93A were wider than their hypomethylated counterparts on average:

641 vs. 511 bp, genome-wide (p=4.73-58, unpaired t-test), 744 vs. 352 bp in promoters (p=2.72-8),

and 650 vs. 434 bp at intragenic loci (p=5.28-32; Fisher's LSD post hoc test for the latter two

groups) (Supplementary Figure 1A,B).

Although methylated at low levels overall, we observed a two-fold greater level of DNA

methylation at non-CpG sites (CHG and CHH; where H=A, T or C). We found that 0.4% and

0.2% of all CHG or CHH sites were methylated in the atherosclerotic lesion (93A) and the

normal aortic tissue (93N), respectively. Focusing on intragenic and promoter differentially

methylated regions (CHG-DMR), we identified 257 intragenic-related (234 genes) and 47

promoter-related (45 genes) CHG-DMRs, which shared many characteristics with CpG-defined

MRs geg nome-wide,e,e,e, w

pGs. CCCConsiiii tttstentt t wiwiwiwithththth

s

o g

,

y

lated DMRs in 93A ere ider than their h pometh lated co nterparts on a e

serveveved dd atatat tthehhh ggeeenome-wide level, DMRsss wwwere mostly hypeermrmrmethylated in the

otticcc c lesion (93AAA) (FiFiFiigurererer 3A)A)A)A). BoBBoth ppprromomoter-r rereeelalalated DDMRsRsRs (70707006, ccorororo reeesppponnndddid ng

, and ddd inninintrtrtrtraaagennicici DDDDMRMRMRRs (7(7(7 33,378787878, cooorrrrrresesesespppondnddiining toototo 222,333,30400404 ggggeneneses),))) wereerereee llargrg llelely

yyylated in 93A andddd mappppepp dd d prpp edddomiini an lltly yy to CCCCG-popp or regggiioi ns (((FiFiFiFigugg re 3B)).

llatedd DMDMRRs ii 9393AA idid thha hth iei hh hth llat ded nt rt




10

DMRs. First, the majority (85.6%) of intragenic CHG-DMRs and all promoter counterparts were

hypermethylated in 93A and mapped mostly to CG-poor regions. Second, intragenic CHG-

DMRs hypermethylated in 93A were wider on average than their hypomethylated counterparts

(740 and 335 bp, p=0.011, unpaired t-test) (Supplementary Figure 1C,D).

We further aimed to examine DNA methylation levels in repetitive elements, since long

interspersed element (LINE) hypomethylation in peripheral blood cell DNA has been proposed

as an atherosclerosis marker25. Accordingly, we modified the alignment procedure and allowed

multiple read mapping and subsequently assessed DNA methylation levels for repetitive

elements (Repeatmasker), including transposons, repeated non-coding RNA genes, transfer RNA

and satellite DNA. Logit-transformed DNA methylation levels were averaged by chromosome.

Consistent with the genome-wide trend, all DNA repeat classes were overall hypermethylated in

93A (Supplementary Table 3). However, a comparison of repeat subtypes revealed several

differences (Supplementary Figure 2). The LINE subtype was the only transposon class with

significantly lower DNA methylation level in 93A (Fisher LSD post hoc test, p<0.05). Alu

elements stood out among SINEs for being consistently hypermethylated in all analyzed

chromosomes. The DNA transposon piggyBac ranked first among all repeated sequences with

respect to the extent of DNA hypermethylation in 93A. Of the non-coding RNA genes,

ribosomal RNAs (rRNAs) were the most hypermethylated in 93A and significantly differed from

the overall hypomethylated tRNAs (p<0.05). Furthermore, subtelomeric regions were more

hypermethylated in 93A than were centromeric loci (p<0.05).

DNA Methylation Map of 450,000 CpG Sites in Matched Atherosclerotic Lesions and

Healthy Aortic Tissues

After describing genome-wide tendencies of DNA methylation changes in the atherosclerotic

evels for reppetitive e e e

RNANAAA genes, ttttrannnsfsfsfsfer

e o

w t

l

(Supplementary Figure 2). The LINE subtype was the only transposon class wit

lo er DNA meth lation le el in 93A (Fisher LSD t h test p<0 05) Al

e DNDNDNA.AAA. LoLoLoL giggg t--trttrtransformed DNA methyllllatatatioi n levels were avavaveraged by chromoso

wwwwittth h the genomemm -wwidididide trtrtrt eene d,d aallll DDNA AA repepeat cclalalasssss ees wwwere ovvverereraaala l hyyyypppermrmrmethyhyhyh lat

lemennntatatataryryryr Tababbllele 333).)) HHHHowevevevveeeer, a cococompmpmpmparrisisii onon oofff rrrrepepepeat sssububububtytyt pepepes rereeevevevev alededd ssevevereraal

(S( upppplp ementaryyy FFigiigi ure 2)2)2 . Thhhe LILINENENE s bbubtytytypepp was thhheh onllly yy transppposon class wit

llo DNDNAA hth llatiio lle ll iin 993A3A ((FiFi hsh LLSDSD t hh t t 0<0 005)5) AlAl




11

tissue, we aimed to define specific differentially methylated loci in a larger cohort of samples,

using the Infinium HumanMethylation450 BeadChip (450k array), a DNA methylation array

covering ~485,000 cytosines22. All DNA methylation microarray data are freely available at the

Gene Expression Omnibus database:

http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?token=zfephwswcyoeotw&acc=GSE46401.

Importantly, despite the donor-matched nature of the analyzed sample pairs, unsupervised

clustering analysis of the unfiltered 450k array data distinguished 10 of 15 atherosclerotic lesions

from their matched healthy counterparts (Figure 4A), thereby indicating the existence of an

atherosclerosis-specific DNA methylation profile that exceeded intra-individual similarities. It is

noteworthy that the separation between normal and diseased specimens was achieved against a

donor-matched and thus genetically paired background, corroborating the existence of consistent

genome-wide DNA methylation changes in atherosclerotic lesions.

We first sought specific regions with significant differences in DNA methylation profile

between atherosclerotic and healthy aortic portions that were consistent in multiple

atherosclerotic samples. The analysis of 15 donor-matched paired atherosclerotic and normal

samples (30 samples in total), irrespective of histological grade, donor sex and age, identified

1,895 candidate differentially methylated CpG sites that were significantly altered in the diseased

sample cohort (paired t-test, p<10-7). Importantly, DNA methylation level at these candidate

differentially methylated CpGs did not significantly correlate with post-mortem time points of

samples collection (data not shown), which is in line with previous reported stability of DNA

methylation after death26. Supervised clustering of the 1,895 sites distinguished the majority (14

out of 15) of atherosclerotic samples, highlighting the specificity of the observed DNA

methylation profiles (Figure 4B).

ngg the existence of f f f anaaa

indiviiiiddudd allll simiii iilililarrrititititieieieies

y n

c s

r

herosclerotic and health aortic portions that ere consistent in m ltiple

y thatatat ttthehehehe ssepepeparratatation between normal andddd ddddisi eased specimennensss was achieved again

chheh ddd and thus ggeeenetticcccalllyyyy paiiirerred backkkggrouunnd, cocorrrrrrrrobbborrraatingg ttthee e eeexisttttenenene ceee of coccons

de DDDDNANANANA mettthyhyh lllalatititionon changngnggees in atatatheheheherroscscllelerrotititicccc lellelesiisisionnnsss.

first soughg t spppeciffffiiici regggiiions witiii hhh h signgg ifififfiiicant dddid ffffferences iinii DDDNANANANA methyylation prpp

hehh lle iti dd hhe lal hth rtiic iti hthat iistent ii lltii lpl




12

To assess the robustness of the differences between the atherosclerotic and healthy aortic

portions observed in the 15 discovery samples initially analyzed by microarrays, we validated 15

selected candidate differentially methylated CpGs by pyrosequencing in 24 additional donor-

matched aortic pairs and 1 by conventional bisulfite sequencing in one of the initial discovery

aortic pairs (16 CpG in total). The selected CpGs mapped to 10 genes known to be involved in

vascular homeostasis, such as HOX family members, PDGFA, PLAT, PRRX1, and PXDN. For all

pyrosequenced CpGs, the average direction of methylation change was consistent in the initial 15

aortic pairs and in the additional 24 pairs (Supplementary Table 4; in the case of HOXA6, only

the expression was determined, see below). In addition, we pyrosequenced the 15 selected CpGs

in the original discovery 15 aortic pairs. In all cases, direct sequencing data and the 450k array

results of the initial aortic pairs were closely correlated (r>0.81, p<0.001). In the case of

MIR23b, we validated one CpG site by conventional bisulfite sequencing in one of the initial

aortic pairs, showing a good agreement between the array and sequencing data (Supplementary

Table 4). Importantly, the DNA methylation profiles of the additional sequenced flanking CpGs

were consistent with the profile of the corresponding 450k array-identified CpGs, thus

confirming the consistency of the observed candidate differentially methylated CpGs. Two

examples (PDGFA and PXDN) are shown in Figure 5. Again, CpG DNA methylation levels did

not significantly correlate with post-mortem time even in this larger cohort (data not shown).

Since atherosclerotic samples generally originated from more distal (abdominal) aortic

portions than their normal counterparts, we assessed whether that the candidate differentially

methylated CpG identified in the aortic samples were genuine disease-specific profiles, rather

than regional epigenetic changes. To distinguish the two profile types, we reasoned that

atherosclerosis-specific differentially methylated CpGs should display consistent profiles within

the case of HOXA6666XX , ,,, o

nced ddd ththththe 15151515 selllel ctctctcteeeedddd C

n r

h

e validated one CpG site by conventional bisulfite sequencing in one of the initi

, showing a good agreement between the array and sequencing data (Supplemen

mportantl the DNA meth lation profiles of the additional seq enced flanking C

nal didididisccscovovovererery 11115 555y aortic pairs. In all casesss,, did rect sequencinnng g g data and the 450k ard

heee innnitial aorticc pppairrss weeerererer cloooossellly corrrrelateted (((r>r>r>0.0.0 8818 , p<0.0000001))). IIn thehehehe casasase ooof

e valllliddididatatatatededed oonene CCCCpGpGGG ssite bybybyy convevevennntioioioi naalll bibibibisuuulfflflfitititite ee sssequququuenenciciingngng in nnn ononone ofoff ttthhhehe iii ininiti

, showing gg a gogg odddd agrgg eement bbbetween thhheh arrayyy anddd seqqquenciiini g gg dddad ta ((Supppppplemen

m rt ltl thhe DNDNAA hth llatiio fofilil ff hth daddidi iti lal ded fflla knkiin CC




13

paired aortic samples and between normal aortas and atherosclerotic non-aortic vessels. To this

end, we analyzed 19 atherosclerotic carotid plaques on the 450k DNA methylation array

platform and calculated the differences between diseased carotid and normal aortic samples for

the initially identified 1,895 CpGs. Applying a p<10-7 and consistent direction of methylation

change as selection criteria, we were able to validate significant atherosclerosis-specific

alterations for 98.0% (1,858 out of 1,895; observed absolute delta range: 0.15-0.49) of the

candidate differentially methylated CpGs (Supplementary Table 5). Those CpGs will be referred

to as dm-CpGs. It is noteworthy that the 1,858 dm-CpGs were common to samples comprising

either the lesion and the underlying media (aorta) or the lesion alone (carotid artery) and are

therefore highly specific for the lesion mass. The majority (91.3%) of atherosclerosis-specific

dm-CpGs were hypermethylated in A samples and mapped to gene-bodies and regions distant

(>4 kbp) from CGIs (compared with the array probe distribution, chi-square test, p<0.05) (Figure

6A-C). Genes harboring atherosclerosis-specific dm-CpGs participate in important aorta-related

processes, particularly those related to endothelial cells (ECs) and vascular smooth muscle cells

(VSMCs) (Table 1). Consistently, biological processes enriched (Fisher’s exact test, p<0.05)

among dm-CpG-harboring genes include VSMC contraction (GO) and ECM matrix formation

(KEGG) (Table 2; see Supplementary Table 6 for a full list of the enriched categories).

Interestingly, 15 dm-CpGs were located within 100 kb of atherosclerosis-associated single

nucleotide polymorphisms (SNPs)27 (Supplementary Table 7), suggesting an interplay between

the risk genotype and differential DNA methylation as methylation quantitative trait loci24.

Finally, by qRT-PCR of the same donor-matched aortic pairs, we attempted to define the

functional consequences of the observed differential methylation. Accordingly, we analyzed 7

dm-CpG-containing genes (HOXA6, HOXA9, MIR23b, PDGFA, PLAT, PRRX1, PXDN)

on to samplp es commmprprprpris

carotitititidddd artttet ry)))) anddd d aaaar

i i

w

o F

n e

partic larl those related to endothelial cells (ECs) and asc lar smooth m scle

ighlylylyly sspepepeciciciififff c fofofofor the lesion mass. The mamamajojority (91.3%) of f f aaatherosclerosis-speci

weere eee e hypermetthyyylateteedd inninn AAA samaamppplees aaannd mmaappeped d d totott geneene-bodododieees and ddd reeegiiiooons didiidist

om CGCGCGCGIsIsIsIs (((coompmpmpararededdd with hh thhththe arraaayyy prprprpr bobobbee dididiiststtririribubububutititiooon, chchchchi-iii sqsqsquuareeee ttteeest, pp<00<0<0.00005)5)5) (F

nes harboring gg athhehh rosclell rosiiiis-spppecififific ddddm-CpCpCC GGsG pppartiiiiciiipapp te iiiin imii popp rtant aorta-re

iti lla ll thho lelat ded t ddo hth leliiall llll (E(ECCs)) dd ll othh lcl




14

presenting differential CpG methylation in gene promoters and gene bodies. All genes exhibited

different transcriptional activity in atherosclerotic and normal samples (shown in Supplementary

Table 4 to allow a direct comparison with DNA methylation data). Promoter CpG methylation

and transcription levels were inversely associated (HOXA6, MIR23b).

Discussion

We present the first genome-wide DNA methylation profile at single nucleotide resolution of a

donor-paired atherosclerotic and normal human aorta. Genome sequencing was complemented

by profiling a larger cohort of donor-paired aortas using a high-throughput DNA methylation

microarray covering more than 450,000 CpG sites of the human genome. Both high-density

microarray and whole-genome bisulfite shotgun sequencing data consistently identified an

atherosclerosis-specific epigenetic signature characterized by genome-wide DNA

hypermethylation in the diseased vessel. Global DNA hypermethylation involved unique and

repetitive sequences, and occurred in CpG and non-CpG contexts. Differentially methylated

CpGs mapped to vascular wall-specific, atherosclerosis-specific genes and are therefore of

potential mechanistic and therapeutic relevance.

Our results are consistent with the previously observed global DNA hypermethylation of

blood leukocyte DNA in cardiovascular patients28. In particular, we replicated the Alu repeat

hypermethylation described in the latter study as a potential non-tissue-specific epigenetic

marker of cardiovascular disease. As further support to our data, the expression of ten-eleven

translocation-2 (TET2), a dioxygenase implicated in active DNA demethylation, is decreased in

atherosclerotic lesions29,30. Notably, global DNA hypermethylation is evoked by an atherogenic

diet in rodents31 and by selected lipoproteins in human macrophages32. Therefore, DNA

g p

hputttt DDDDNANANANA mmmmetetetethyhyhyhylalaaatitititio

covering more than 450,000 CpG sites of the human genome. Both high-density

o

y n

equences, and occurred in CpG and non-CpG contexts. Differentially methylate

coverinining g g momm reree than 450,000 CpG sites off the human genomomme. Both high-density

aandndndd whole-ggeenomoome bibibib sususulflflfl itititee e shshshotoo ggunnn ssequueencicicingngg dddattttaaa cconsnsn sisstentnttntlllyl iiiidedededentntntifififfieieiei d ddd anaa

osiiissss-spspspspececececifififficicici eeepipipiigegegeg neneneetitt c sisisis gngngngnatatata urrreee e chchchhararara acacacctetetet riririizezezezed dd bybybyby ggggenenenomomomomeee-wwwiw dededede DDDDNANANAN

ylation in the didididiseseseseasasasseeedddd vevevevessssselelelel. GGGGlololol bababaallll DNDNDNDNAAA hyhyhyh peeeerrrrmememem ththththylyllatatatatioioioon nn inininnvovovovolved unique an

eeeququenenceces,s, aandnd ooccccururrereddd inin CCCpGGpG aandndd nnonon-CpCCpG GG cocontntexextstts.. DiDDiffffffererenentititialallylly mmetethyhylalatete




15

hypermethylation emerges as an overlapping feature of the natural history of atherosclerosis and

atherosclerosis-related stimuli.

The pattern of global DNA hypermethylation observed in atherosclerotic lesions indicates

a unique epigenome that is distinct from those of other human diseases both in the direction and

magnitude of DNA methylation changes. In cancer cells for example, a global hypomethylation

occurs in the context of mega-base scale blocks that lose DNA methylation. However, a focal

gain of DNA methylation was frequently observed altering gene promoter profiles including

those of tumor suppressor genes4,16,17. Although at smaller magnitude, non-tumoral disorders,

such as systemic lupus erythematosus18 or type 1 diabetes19, also revealed global DNA

hypomethylation. Overall, the extent of changes in DNA methylation was comparatively lesser

in atherosclerotic samples compared to cancer. Cancer studies applying the same DNA

methylation profiling technology yielded thousands of differentially methylated CpG of high

magnitude in primary cancer samples33,34. Interestingly, a genome-wide comparison of

atherosclerotic and age-related changes20 revealed a similar number of differentially methylated

CpGs (~600,000); however the aged samples presented mainly hypomethylated DMR (87%

hypomethylated), while the opposite was observed in atherosclerotic samples (80%

hypermethylated). Our data indicate that despite aging being a known independent CVD risk

factor, age-driven global hypomethylation of the vascular genome is not an underlying

mechanism of atherosclerosis in our sample. Our study confirms that DNA methylation changes

in a non-cancerous context appear at specific loci, rather than presenting extensive gains or

losses in large regions as occurs in tumoral samples.

In conclusion, we have identified the genome-wide DNA methylation changes and those

locus-specific CpG alterations occurring during the onset and progression of human

non-tumoral disoooordrdrdrde

aled glgllgl bbobb llall DDDDNANANAN

e

l

n profiling technology yielded thousands of differentially methylated CpG of hig

i

otic and age related changes20 re ealed a similar n mber of differentiall meth

latioioioion.n. OOOOveveverrrallllll,,, the extent of changes in n DNDNDNA methylation nf wwwaw s comparatively le

leere ooootic sampless commpppareeeedd d to cccannnceer. CCCancecer sttudududieieiess appppplyingngg thehehee sammmmeee DNDNDNNA

n profofofillililinininingg techchhnonololol gygy yyyieldldlddeeeded thohohoh usususananana ddsds ooff ff dididifffffffererenenentialalallylylyly mm ttetethylalalalatetetedddd CpCpC GGGG ofoff hhhig

in ppprimaryyy cancer sampppllles33333333,333444. IIInterestiiini glglly,y,y, a gggenome-widididde comppparison of

iti dd llatedd hch 2020 lal ded iimilil bbe fof ddififffe ntiiallll hth




16

atherosclerotic lesions. These lesions present a unique epigenomic profile, compared with other

blood-related diseases, neoplastic transformations and aging20, whereby atherosclerosis is

characterized by the prominence of DNA hypermethylation. The present study describes the first

reference DNA methylome sequences of normal and atherosclerotic aortic human tissue, a

resource that will be highly valuable to the cardiovascular and epigenetic research community.

Further, our analysis identified novel disease-related genes with potential value as biomarkers in

future clinical applications.

Acknowledgments: We thank Dr. Gertrud Lund (CINVESTAV Irapuato) for critically reading the manuscript.

Funding Sources: This work was supported by the European Research Council (ERC) grant EPINORC under agreement n° 268626, the MICINN Project – SAF2011-22803, the Cellex Foundation, the Botin Foundation, the European Community's Seventh Framework Programme (FP7/2007-2013) from grant HEALTH-F5-2011-282510 – BLUEPRINT and the Health and Science Departments of the Generalitat de Catalunya. S.Z. was supported by a CONACYT (Mexico) Sabbatical Fellowship no. 166058. HH is a Juan de la Cierva Postdoctoral Researcher.ME is an Institució Catalana de Recerca i Estudis Avançats (ICREA) Research Professor.

Conflict of Interest Disclosures: None

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3. Bock C. Analysing and interpreting DNA methylation data. Nat Rev Genet. 2012;13:705–719.

4. Heyn H, Esteller M. DNA methylation profiling in the clinic: applications and challenges. Nat Rev Genet. 2012;13:679–692.

5. Urdinguio RG, Sanchez-Mut JV, Esteller M. Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies. Lancet Neurol. 2009;8:1056-1072.

uato) fffforororor ccccriririrititititicacacacalllllllly y y y rererereaaaa

o aunder agreement n° 268626, the MICINN Pr ect – SAF2011-22803, the Cellex

n, the Botin Foundation, the European Community's Seventh Framework Programn

p Tr

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17

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causes fffof cardidididiovvvasasasascu

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A. FuFuFFuncncncnctititit onss ofofff DDDNANANAA metetethyhyhyhylationonon::: isissslllandndddss, statatartrtrtrt sssittitites, geggegenene bbbboddddieieieiesss and dd bbebeyoyo dndnd. 2012;13:484–4444929292...

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Y, Bai Y, Qin L, Zhang P, Yi T, Teesdale SA, et al. Interferon-gamma induces hmooth muscle cell proliferation and intimal expansion phosphati linositol 3-m 1

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21

Table 1: Relevant genes mapping to atherosclerosis-specific dm-CpGs

Gene Relevant function

A2BP1 Vascular lesion calcification35

CALD1 SMC contraction36

DAAM1 Vascular remodeling37

EGFR Angiotensin II signaling in VSMC38

FBN2 Atherosclerotic plaque stability39

HOXA9 Regulation of pro-inflammatory factors in EC40

HOXB3 Angiogenesis41

KCNMA1 VSMC contraction42

MAP1B Angiotensin II intake43

MIR23b Enriched in EC cells, stimulates angiogenesis44

MYH10 Angiotensin II signaling in cell migration45

PDGFD Monocyte migration to the atherosclerotic plaque46

PLA2G10 Controls atherosclerotic plaque size47

PLAT Blood coagulation, EC migration48

RPTOR VSMC proliferation49

PRKCE Mediates platelet-derived growth factor signaling in VSMC50

PRRX1 VSMC phenotype regulation51

PTK2 LDL signaling in VSMC52

PXDN ox-LDL-induced EC apoptosis53

TSC22D1 Transforming growth factor-beta signaling in VSMC54

EC, endothelial cells; LDL, low density lipoprotein; SMC, smooth muscle cells; VSMC, vascular SMC

Table 2: Synopsis of selected relevant biological processes enriched for genes mapping to atherosclerosis-specific dm-CpGs in KEGG, GO and tissue expression (UP_TISSUE) databases (p<0.05)

KEGG VSMC contractionECM-receptor contact

GO Development CytoskeletonECM

Tissue specificity Aortic ECEC

Controls atherosclerotic plaque sizeqControlss atherosclerotic plaque sizeqBloooooddd d coagulation, EC migration48

VSMCCC pprrrolililifefefeerraratititiiononon49 49494

Mediatees plaateeelet-dedederived d gggroowthhh facttor siiigngngnalalinng iniin VSMMMC55505

VSVSVSV MCMCMCM pppheheheh nononotytytytypepp rrrregegegululululationnnn51515151

LDL signgngngnalalinininng gg g inininn VVVSMSMSMMCCCC52

ox-LDL-iniii dudd ced dd ECECECE apo tpttosiiis5353533

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22

Figure Legends:

Figure 1: Schematic workflow of sample origin and the techniques used.

Figure 2: Histology and WGBS of aortic donor-matched samples. A. Macroscopic image of the

aortic sample no. 93. The left-hand and right-hand part of the aorta were macroscopically

identified as non-atherosclerotic (93N) and as atherosclerotic (93A), respectively. The insert rule

is 4 cm-long. B-C. Histology of 93N and 93A, respectively. Notice the thickening and presence

D. Circos representation of the

CpG methylation level of 93N (inner track) and 93A (middle track) DNA. Average methylation

levels of variant regions in 10 Mb-wide windows are shown. Average methylation levels are

expressed as values (0-1) in blue color. The color code of the external track indicates the delta

(red and green, hypermethylation and hypomethylation in 93A relative to 93N, respectively).

E-F. Total number of methylated CpG sites and CpG methylation level (%) in 93N and 93A

DNA. G. Illustrative example of CpG methylation levels in 93N (green line) and 93A (red line)

in chromosome 15 and 20. Raw and interpolated traces are shown.

Figure 3: Differentially methylated regions (DMRs) between 93A and 93N aortic samples. A.

Percentage of CpG-DMRs hypermethylated in 93A relative to 93N (solid part of bars) and

hypomethylated counterparts (open part of bars). In each panel, autosomes are ordered by

number left to right, the X chromosome is furthest to the right. B. Frequency of promoter and

intragenic CpG-DMRs that are hypermethylated in 93A compared to 93N and their mapping

relative to CpG islands (CGIs).

e thickening and prprprpreseee

Circos representtatatttioioioion

ylation level of 93N (inner track) and 93A (middle track) DNA. Average methyl

ariant re ons in 10 Mb-wide windows are shown. Average met lation levels ar

a

green, hypermethylation and hypomethylation in 93A relative to 93N, respective

ylatioioioion n lelelelevevevellll offf 99993N (inner track) and 93AAA ((middle track) DNDNDNNA. Average methyl

aririiannnnt regions ininin 100 0 MMbMbM -w-w-w-wide wwiw ndnndowwwss aree showowwwn.n.n.n AAAvvverragee mmmetete hhhyh latttit ooon leeeveeelss ar

as vavaaalulululues (000 11-1) ) ) inii bbblllul e collllor. Thehhh colllor c ddodde fffof ttthhhe e tttxternallll trackkk k iiiindiiicattet s thththe

grgrgreeeeeenn,n, hhypypypererermememeththylylatatatioionnn ananandd hyhypopopomememeththylylatatatioionnn inin 993A3A rrrelelatatativiveee tototo 993N3N,, rererespspspececectitivevv




23

Figure 4: Cluster analysis of donor-matched aortic samples. A. Unsupervised clustering of the

atherosclerotic (A, red) and normal (N, blue) samples of the 15 donor-matched aortic samples

subjected to 450k array analysis. The histological grade is indicated to the left hand side for each

sample code. Symbols for the N samples: PIT, pathological intimal thickening; IT, intimal

thickening; N, normal histology. B. Supervised clustering of the 1,895 candidate differentially

methylated CpGs identified by 450k array analysis. The blue/red color bar indicates the sample

type according to the same code as in panel A. Each column represents a sample, each horizontal

line represents the methylation levels of a given CpG across samples. Methylation levels are

expressed as 0-1 values (green and red, unmethylated and completely methylated,

respectively). Notice the nearly perfect segregation of the A and N samples and the tendency for

hypermethylation in A samples.

Figure 5: Examples of candidate differentially methylated CpG validation by pyrosequencing.

A-B. PDGFA. C-D. PXDN. The CpG ID is shown in both cases. A and C. Correlation between

450k array and pyrosequencing data. Each dot corresponds to an individual intra-aortic pair

DNA methylation difference. For simplicity, only one of two CpGs mapping to PXDN is shown.

B and D. Methylation profile determined by 450k arrays - cg14496282 for PDGFA, cg07608848

and cg15796818 for PXDN (average delta- ; black circles) and of the same CpGs or flanking

CpGs not included in 450k arrays (average % methylation level determined by pyrosequencing;

black squares). Note the consistent direction of differential methylation between 450k arrays and

pyrosequencing in both cases. Delta- values have been multiplied by 100 for ease of

comparison.

s a sample, each hohohohorrirr

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as 000-1-1-1 vavavalulululuess ((((green and red, unmethylalalalateed and comppleteelylylyy methylated,

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24

Figure 6: Features of atherosclerosis-specific dm-CpGs. A. Distribution according to the

direction of DNA methylation change (A relative to N). B-C. Mapping relative to gene

compartments and relative to CGIs, respectively. In gene compartments mapping, CpG counts

sum to more than the total of each dm-CpG sets, as all mapping variants are counted for CpGs

embedded in alternative transcripts. Promoter indicates the region between the transcription start

site and the -1,500 position.



SUPPLEMENTAL MATERIAL

0 200.25

All Genome Promoter IntragenicA B

0.20

0.15

0.05

0.10

0.20

0.15

0 05

0.10

Den

sity

0.00 0.00

0.05

Length (log2bp) Length (log2bp)

5 10 15 105 5 510 10

All Genome Promoter IntragenicC D

0.1

Den

sity

0.2 0.4

0.2

0.0 0.0

5 5 515 15 155 10 15

Length (log2bp) Length (log2bp)

Supplementary Figure 1. DMR width in CpG- and CHG-contextsA-B, CpG-DMRs. C-D, CHG-DMRs. A-C, red, green and blue traces correspond towhole genome, promoters and intragenic sequences, respectively. B-D, red and greentraces correspond to DMRs hypermethylated and hypomethylated in 93 A, respectively.Note the larger size of DMRs hypermethylated in 93A compared to hypomethylatedcounterparts (B), and the larger size of CHG-DMRs particularly in promoters (compareB and D).

1

p<0.04A

0,2

Bp<0.05

e

1 5

-1

-0,5

0

0,5

0 4

-0,3

-0,2

-0,1

0

0,1

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tion

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e

-1,5

0,4

0,6

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ce

p=0.008

C

-0,4

0,2

0,3

p=0.017

D

p=0.043

-0,4

-0,2

0

0,2

A-N

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tion

diff

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-0,2

-0,1

0

0,1

Supplementary Figure 2. CpG context methylation profiles of WGBS-derivedrepeated sequencesA, All transposon classes. B, SINE. A-B, The highest p value in the comparison ofLINE ith ll th t t d f Al ith ll th SINE i h N tiLINE with all other transposon types and of Alu with all other SINE is shown. Noticethe consistent hypermethylation of Alu elements across all chromosomes analyzed. C,Non-coding RNA genes. D, Satellite DNA. Each bar corresponds to the averagemethylation difference in an individual chromosome. Data are ordered by increasing A-N methylation difference within each sequence type.

Supplementary,Table,1.,Clinical,characteristics,of,vascular,samplesTable&content:&donor.paired&aortic&samples;&carotid&atherosclerotic&samples.

Donor.paired&aortic&samplesSample&no. Sex Age Cause&of&death Histological&

class,&N&sample

Histological&class,&A&sample&

AHA&classification,&A&sample

Epigenomics&analysis

DNA&methylation&validation

Expression&analysis

93 F 88 Pneumonia N Calcified&plaque

VII WGBS/450k&array Yes Yes

95 F 69 Mesotelioma N PIT III 450k&array Yes96 M 71 Chronic&lymphocytic&leucemia N+IT Calcified&

fibrous&plaqueVII 450k&array Yes

97 M 69 MS IT Calcified&plaque

VII 450k&array Yes Yes

98 M 55 Lymphoma N PIT III 450k&array Yes99 F 65 Urinary septic shock IT PIT.FCA IV 450k&array Yes100 M 73 Pneumonitis IT Calcified&

plaqueVII 450k&array Yes

101 M 45 Systemic&amyloidosis& IT PIT III 450k&array Yes102 M 65 Post.cardiac&transplant&septic&shock PIT Calcified&

plaqueVII 450k&array Yes

103 M 61 Cerebral&infarction IT Calcified&plaque

VII 450k&array Yes

104 F 71 Metastatic&renal&cancer IT FCA/Calcified&fibrous&plaque

V 450k&array Yes Yes

5 F 54 Pneumococcal&pneumonia PIT FCA IV 450k&array Yes Yes6 M 46 Septic&shock IT Calcified&

fibrous&plaqueVII 450k&array Yes Yes

7 M 72 Cardiogenic&shock IT Calcified&fibrous&plaque

VII 450k&array Yes

9 M 78 Pulmonary&edema IT Calcified&fibrous&plaque

VII 450k&array Yes

12 M 50 Pheochromocytoma IT FCA IV Yes13 M 74 Syringomyelia IT Calcified&

fibrous&plaqueVII Yes

14 M 72 Metastatic&pulmonary&cancer IT Calcified&fibrous&plaque

VII Yes

15 M 64 Septic&shock IT Calcified&fibrous&plaque

VII Yes

16 F 76 Dilated&cardiomyopathy IT PIT III Yes17 M 63 Myocardial ischemia IT Calcified&


18 F 66 Renal&cancer IT Calcified&fibrous&plaque

VII Yes

19 M 57 Ischemic&cardiopathy IT Calcified&fibrous&plaque

VII Yes

21 M 41 Cardiomegaly.arrhythmia N PIT III Yes22 F 85 Pneumonia IT Calcified&


23 M 67 Chronic&obstructive&pulmonary&disease IT Calcified&fibrous&plaque

VII Yes

24 M 36 Peritonitis N PIT III Yes27 M 77 Primitive&neuroectodermal&tumor IT PIT III Yes28 M 81 Ischemic&cardiopathy IT Calcified&

plaqueVII Yes

29 M 64 Acute renal failure N PIT III YesHC21/12 F 80 Acute&pneumonia N FCA IV YesHC22/12 M 85 Pneumonia/pulmonar&fibrosis IT PIT III YesHC27/12 F 58 Acute&myeloid&leukemia IT FCA IV YesHC31/12 F 62 Hepatocarcinoma/hepatic&cirrhosis IT PIT III YesHC46/12 F 67 Pulmonary&thromboembolism N FCA IV YesHC64/12 M 83 Myocardial&ischemia IT FCA IV YesHC65/12 F 51 Cerebral&hemorrhage N FCA IV YesHC67/12 F 88 Cerebral&hemorrhage IT FCA IV YesHC79/12 F 82 Autoimmune&hepatitis/Hepatic&necrosis IT Calcified&


Legend:&N=normal;&IT=Intimal&thickening,&adaptive&intimal&thickening;&PIT=Pathologic&Intimal&Thickening;&FCA=&Fibrous&Cap&Atheroma.

Carotid&atherosclerotic&samplesSample&no. Sex Age Epigenomics&analysis30 M 67 450K&array154 F 65 450K&array172 F 74 450K&array180 M 76 450K&array219 M 67 450K&array220 M 66 450K&array344 M 74 450K&array390 F 72 450K&array413 M 73 450K&array414 M 62 450K&array423 M 58 450K&array427 M 64 450K&array490 M 59 450K&array495 M 75 450K&array505 F 68 450K&array517 F 69 450K&array523 M 68 450K&array547 F 62 450K&array564 M 71 450K&array

Supplementary Table 2. Oligonucleotides used in pyrosequencing, conventional BS and quantitative expression analysis

Pyrosequencing Quantitative expression analysisGene CpG ID PCR primers Sequencing primer PCR primersHOXA2 cg23979631 ATGATAATTTGGGTTTTAATTAAAAGAAGT TTATTGTTTGTTTGATTGATTTAA

ACACACACACTAAATAAATCCTTACAAHOXA6 CATGGCTCCCATACACAGC

AAAGCACTCCATGACGAAGGHOXA9 cg03217995 TGGTGAGGTATATGTTGAATAGAAA GTGTTTTGTATAGGGGTAT CAGTTCCAGGGTCTGGTGTT

ACCAATTCAACAAAATTCTACACT GCGCCTTCTCTGAAAACAATHOXA9 cg16913789,

cg25188395TTGGAAGGTTTTYGGAGTTGGGTAAGT AATTTGTTATGGGGATTTT

ACCRATTCCTTCCACTTCTTACCTHOXA11AS cg05311410,

cg17466857GGAATTTTTTYGGGGTTAGAGTTTGAAG GATTATATTTTTTTATTTATGGTTA

AAAACAACCCCTATACCTCTATCTHOXC4 cg03146625,

cg15648389AAAGGAGGGAGTAGGTAGTT ACTATAAAACRTCATAAATCAATCT

ATCATAACTTACCAAAACTCAACTATATTHOXC11 cg23395715 GGTGAAGGGAAGTGTTTGATGT GATTTTGATTTAAAAGAAAATATAT

ACTTTACACACCTAACACCAAATTAAHOXC11 cg02384661 TGTTYGGATTAGGTGGGGGAGG GTGAAAAGATTYGTTAAGATAGTAT

ACTTTACACACCTAACACCAAATTAAPDGFA cg14496282 GGATGGTATAGTTTTTTTGGTTAATAAGT GGGGTAGGTTYGTTTTTAATTATT TCAGGTCGACCCCACGTCCG

ACCCAAAAAAATAACATTTCTATTATATCC ACTCCCTAGGCCTTCCCGTGTCPLAT cg01419713 GGGYGATTTTTTGTGTTTGGTAAAGAT TTTGTTAGGGGTGGG CATGATTGCTTCACAGCGTC

CTAAAACAATACAACCAACCTCAATTTC GAAACTTAAGGAGGCCGGAGPRRX1 cg21914290 GTGGTGGTTTTTAGATATTGTAGGGGAAG GGAYGTTATTTTTAAGAAGGGAG TGTCCTATTCCTTCGCTGCT

AACCAACCCRACTCCATACCC CGGAGCCTGCTGGAGTCPXDN cg07608848,

cg15796818AGGGATGAAAAAGGAATAGATATGG AGGTTTATTTTGGGGATT CGGGTGCAGAGCGACGTGTT

ATATTCTCCCCRACCCAACTAACTC CCTGCCACACCCGGAGGTCT

Conventional BSMIR23b cg00351472 TTGTGTTTATGAAAATTATTTTTG Applied Biosystem cat. no. 4427975

AAAAAAAACACCATTTACACTAAT

The$first$and$second$primer$for$each$entry$are$forward$and$reverse,$respectively.

Supplementary,Table,3.,WGBS4derived,DNA,methylation,profile,of,repeated,sequencesTable&content:&CpG&methylation;&CHG&methylation.

CpG&methylationSatellite&DNAChromosome Subtype Methylation&

level&in&93AMethylation&level&in&93N

Methylation&difference,&93AD93N

1 Centromere 0.72 0.72 0.012 Centromere 0.49 0.46 0.033 Centromere 0.26 0.26 D0.014 Centromere 0.84 0.79 0.055 Centromere 0.26 0.29 D0.036 Centromere 0.31 0.23 0.087 Centromere 0.41 0.41 0.008 Centromere 0.43 0.43 0.019 Centromere 0.54 0.54 0.0010 Centromere 0.30 0.42 D0.1111 Centromere 0.31 0.34 D0.0312 Centromere 0.22 0.25 D0.0314 Centromere 0.54 0.54 0.0015 Centromere 0.38 0.36 0.0216 Centromere 0.23 0.26 D0.0317 Centromere 0.66 0.63 0.0418 Centromere 0.43 0.39 0.0419 Centromere 0.60 0.53 0.0720 Centromere 0.52 0.49 0.0321 Centromere 0.39 0.36 0.0322 Centromere 0.64 0.59 0.05X Centromere 0.28 0.25 0.041 Generic 0.52 0.52 0.002 Generic 0.61 0.60 0.013 Generic 0.77 0.78 D0.014 Generic 0.50 0.46 0.045 Generic 0.77 0.69 0.086 Generic 0.69 0.50 0.197 Generic 0.51 0.49 0.028 Generic 0.79 0.79 0.009 Generic 0.71 0.68 0.0310 Generic 0.52 0.48 0.0311 Generic 0.78 0.78 D0.0112 Generic 0.86 0.85 0.0213 Generic 0.78 0.77 0.0114 Generic 0.81 0.77 0.0415 Generic 0.73 0.74 D0.01

16 Generic 0.59 0.58 0.0117 Generic 0.59 0.48 0.1218 Generic 0.43 0.40 0.0319 Generic 0.49 0.45 0.0420 Generic 0.63 0.74 D0.1021 Generic 0.53 0.51 0.0222 Generic 0.49 0.54 D0.051 Telomere 0.60 0.58 0.022 Telomere 0.67 0.65 0.024 Telomere 0.75 0.71 0.045 Telomere 0.59 0.62 D0.036 Telomere 0.76 0.73 0.037 Telomere 0.43 0.45 D0.028 Telomere 0.75 0.68 0.069 Telomere 0.68 0.65 0.0310 Telomere 0.64 0.46 0.1811 Telomere 0.81 0.68 0.1212 Telomere 0.71 0.62 0.0913 Telomere 0.71 0.53 0.1814 Telomere 0.77 0.75 0.0315 Telomere 0.81 0.76 0.0516 Telomere 0.65 0.63 0.0217 Telomere 0.43 0.49 D0.0618 Telomere 0.63 0.58 0.0419 Telomere 0.75 0.70 0.0520 Telomere 0.62 0.59 0.0321 Telomere 0.71 0.65 0.0522 Telomere 0.71 0.62 0.09X Telomere 0.74 0.71 0.03

TransposonsChromosome Type Subtype Methylation&



7 DNA DNA 0.57 0.74 D0.169 DNA DNA 0.75 0.71 0.0411 DNA DNA 0.69 0.62 0.0817 DNA DNA 0.94 0.86 0.071 DNA hAT 0.68 0.53 0.162 DNA hAT 0.65 0.68 D0.023 DNA hAT 0.70 0.62 0.084 DNA hAT 0.60 0.50 0.105 DNA hAT 0.55 0.37 0.186 DNA hAT 0.53 0.72 D0.197 DNA hAT 0.80 0.80 0.00

8 DNA hAT 0.64 0.53 0.119 DNA hAT 0.51 0.54 D0.0310 DNA hAT 0.73 0.69 0.0511 DNA hAT 0.80 0.60 0.2012 DNA hAT 0.51 0.44 0.0714 DNA hAT 0.62 0.49 0.1315 DNA hAT 0.84 0.81 0.0216 DNA hAT 0.66 0.67 D0.0117 DNA hAT 0.46 0.36 0.1118 DNA hAT 0.00 0.40 D0.4019 DNA hAT 0.87 0.87 0.0020 DNA hAT 1.00 0.83 0.1722 DNA hAT 0.78 0.73 0.06X DNA hAT 0.36 0.71 D0.361 DNA hATDBlackjack 0.75 0.73 0.022 DNA hATDBlackjack 0.69 0.72 D0.043 DNA hATDBlackjack 0.15 0.11 0.047 DNA hATDBlackjack 0.78 0.65 0.138 DNA hATDBlackjack 0.89 0.75 0.149 DNA hATDBlackjack 0.86 0.74 0.1210 DNA hATDBlackjack 0.66 0.62 0.0411 DNA hATDBlackjack 0.81 0.72 0.0913 DNA hATDBlackjack 0.97 0.82 0.1514 DNA hATDBlackjack 0.70 0.45 0.2515 DNA hATDBlackjack 0.82 0.79 0.0316 DNA hATDBlackjack 0.60 0.58 0.0117 DNA hATDBlackjack 0.75 0.76 D0.0118 DNA hATDBlackjack 0.87 0.85 0.0219 DNA hATDBlackjack 0.67 0.63 0.0420 DNA hATDBlackjack 0.89 0.82 0.0721 DNA hATDBlackjack 0.52 0.46 0.0622 DNA hATDBlackjack 0.80 0.73 0.07X DNA hATDBlackjack 0.74 0.76 D0.021 DNA hATDCharlie 0.63 0.63 0.002 DNA hATDCharlie 0.77 0.75 0.023 DNA hATDCharlie 0.68 0.64 0.034 DNA hATDCharlie 0.71 0.67 0.045 DNA hATDCharlie 0.84 0.83 0.006 DNA hATDCharlie 0.72 0.71 0.017 DNA hATDCharlie 0.70 0.68 0.018 DNA hATDCharlie 0.76 0.71 0.049 DNA hATDCharlie 0.71 0.68 0.0310 DNA hATDCharlie 0.78 0.79 D0.0111 DNA hATDCharlie 0.66 0.73 D0.0712 DNA hATDCharlie 0.60 0.62 D0.0213 DNA hATDCharlie 0.70 0.72 D0.03

14 DNA hATDCharlie 0.60 0.50 0.1015 DNA hATDCharlie 0.71 0.72 D0.0116 DNA hATDCharlie 0.72 0.69 0.0317 DNA hATDCharlie 0.73 0.72 0.0218 DNA hATDCharlie 0.59 0.53 0.0619 DNA hATDCharlie 0.76 0.77 0.0020 DNA hATDCharlie 0.60 0.62 D0.0121 DNA hATDCharlie 0.54 0.51 0.0322 DNA hATDCharlie 0.73 0.75 D0.02X DNA hATDCharlie 0.73 0.68 0.051 DNA hATDTip100 0.60 0.55 0.052 DNA hATDTip100 0.65 0.63 0.023 DNA hATDTip100 0.40 0.68 D0.284 DNA hATDTip100 0.62 0.48 0.145 DNA hATDTip100 0.61 0.60 0.016 DNA hATDTip100 0.81 0.68 0.147 DNA hATDTip100 0.70 0.65 0.058 DNA hATDTip100 0.82 0.77 0.059 DNA hATDTip100 0.73 0.74 D0.0110 DNA hATDTip100 0.82 0.82 0.0011 DNA hATDTip100 0.60 0.57 0.0412 DNA hATDTip100 0.69 0.73 D0.0413 DNA hATDTip100 1.00 0.63 0.3814 DNA hATDTip100 0.67 0.81 D0.1315 DNA hATDTip100 0.64 0.62 0.0216 DNA hATDTip100 0.69 0.70 0.0017 DNA hATDTip100 0.69 0.66 0.0418 DNA hATDTip100 0.39 0.60 D0.2219 DNA hATDTip100 0.87 0.77 0.1020 DNA hATDTip100 0.76 0.79 D0.0321 DNA hATDTip100 0.58 0.44 0.1522 DNA hATDTip100 0.62 0.76 D0.14X DNA hATDTip100 0.65 0.70 D0.056 DNA Merlin 0.50 0.54 D0.041 DNA MuDR 0.92 0.86 0.064 DNA MuDR 0.32 0.30 0.025 DNA MuDR 0.51 0.46 0.056 DNA MuDR 0.92 0.93 D0.017 DNA MuDR 0.91 0.90 0.018 DNA MuDR 0.90 0.97 D0.079 DNA MuDR 0.42 0.41 0.0011 DNA MuDR 0.63 0.62 0.0115 DNA MuDR 0.53 0.29 0.2417 DNA MuDR 0.87 0.88 D0.01X DNA MuDR 0.79 0.77 0.021 DNA PiggyBac 0.47 0.18 0.29

2 DNA PiggyBac 0.53 0.53 0.013 DNA PiggyBac 0.86 0.64 0.225 DNA PiggyBac 0.96 0.98 D0.027 DNA PiggyBac 0.67 0.56 0.109 DNA PiggyBac 0.93 0.91 0.0213 DNA PiggyBac 0.27 0.24 0.0317 DNA PiggyBac 0.92 0.98 D0.0719 DNA PiggyBac 0.67 0.52 0.1522 DNA PiggyBac 0.86 0.64 0.221 DNA TcMar 0.64 0.48 0.167 DNA TcMar 0.56 0.72 D0.169 DNA TcMar 0.73 0.75 D0.0210 DNA TcMar 0.87 0.86 0.0122 DNA TcMar 0.33 0.41 D0.091 DNA TcMarDMariner 0.72 0.67 0.052 DNA TcMarDMariner 0.88 0.87 0.013 DNA TcMarDMariner 0.54 0.58 D0.045 DNA TcMarDMariner 0.91 0.79 0.127 DNA TcMarDMariner 0.51 0.43 0.088 DNA TcMarDMariner 0.70 0.68 0.039 DNA TcMarDMariner 0.80 0.75 0.0510 DNA TcMarDMariner 0.72 0.66 0.0611 DNA TcMarDMariner 0.69 0.53 0.1612 DNA TcMarDMariner 0.43 0.26 0.1713 DNA TcMarDMariner 0.26 0.14 0.1214 DNA TcMarDMariner 0.53 0.38 0.1415 DNA TcMarDMariner 0.54 0.57 D0.0316 DNA TcMarDMariner 0.79 0.79 0.0017 DNA TcMarDMariner 0.68 0.79 D0.1118 DNA TcMarDMariner 0.78 0.73 0.0520 DNA TcMarDMariner 0.92 0.85 0.0721 DNA TcMarDMariner 0.47 0.44 0.0322 DNA TcMarDMariner 0.65 0.65 0.00X DNA TcMarDMariner 0.84 0.77 0.071 DNA TcMarDTc2 0.77 0.73 0.032 DNA TcMarDTc2 0.63 0.58 0.043 DNA TcMarDTc2 0.56 0.63 D0.064 DNA TcMarDTc2 0.76 0.73 0.035 DNA TcMarDTc2 0.86 0.90 D0.046 DNA TcMarDTc2 0.55 0.74 D0.207 DNA TcMarDTc2 0.70 0.51 0.198 DNA TcMarDTc2 0.60 0.80 D0.209 DNA TcMarDTc2 0.78 0.80 D0.0110 DNA TcMarDTc2 0.83 0.89 D0.0611 DNA TcMarDTc2 0.45 0.67 D0.2213 DNA TcMarDTc2 0.88 1.00 D0.13

14 DNA TcMarDTc2 0.55 0.54 0.0215 DNA TcMarDTc2 0.68 0.83 D0.1416 DNA TcMarDTc2 0.69 0.73 D0.0418 DNA TcMarDTc2 0.74 0.76 D0.0321 DNA TcMarDTc2 0.74 0.70 0.0422 DNA TcMarDTc2 0.48 0.50 D0.02X DNA TcMarDTc2 0.85 1.00 D0.151 DNA TcMarDTigger 0.72 0.70 0.022 DNA TcMarDTigger 0.72 0.75 D0.023 DNA TcMarDTigger 0.67 0.66 0.024 DNA TcMarDTigger 0.67 0.63 0.035 DNA TcMarDTigger 0.83 0.83 D0.016 DNA TcMarDTigger 0.70 0.72 D0.027 DNA TcMarDTigger 0.69 0.70 D0.018 DNA TcMarDTigger 0.76 0.86 D0.109 DNA TcMarDTigger 0.73 0.73 0.0010 DNA TcMarDTigger 0.66 0.73 D0.0711 DNA TcMarDTigger 0.75 0.71 0.0312 DNA TcMarDTigger 0.62 0.64 D0.0213 DNA TcMarDTigger 0.75 0.80 D0.0514 DNA TcMarDTigger 0.64 0.61 0.0315 DNA TcMarDTigger 0.78 0.75 0.0316 DNA TcMarDTigger 0.69 0.72 D0.0217 DNA TcMarDTigger 0.76 0.78 D0.0218 DNA TcMarDTigger 0.63 0.61 0.0119 DNA TcMarDTigger 0.78 0.76 0.0320 DNA TcMarDTigger 0.62 0.57 0.0521 DNA TcMarDTigger 0.58 0.56 0.0322 DNA TcMarDTigger 0.64 0.65 D0.01X DNA TcMarDTigger 0.71 0.72 D0.011 LINE CR1 0.67 0.66 0.012 LINE CR1 0.70 0.73 D0.033 LINE CR1 0.48 0.86 D0.384 LINE CR1 0.59 0.65 D0.075 LINE CR1 0.62 0.67 D0.056 LINE CR1 0.48 0.55 D0.077 LINE CR1 0.72 0.70 0.028 LINE CR1 0.59 0.63 D0.049 LINE CR1 0.74 0.74 0.0010 LINE CR1 0.77 0.83 D0.0611 LINE CR1 0.56 0.54 0.0212 LINE CR1 0.74 0.68 0.0613 LINE CR1 0.82 0.91 D0.0914 LINE CR1 0.74 0.71 0.0315 LINE CR1 0.67 0.68 D0.0116 LINE CR1 0.67 0.67 0.00

17 LINE CR1 0.70 0.73 D0.0318 LINE CR1 0.86 0.56 0.3019 LINE CR1 0.80 0.78 0.0220 LINE CR1 0.58 0.40 0.1821 LINE CR1 0.43 0.48 D0.0522 LINE CR1 0.60 0.58 0.02X LINE CR1 0.71 0.70 0.0217 LINE DongDR4 0.68 0.80 D0.121 LINE L1 0.59 0.59 0.012 LINE L1 0.58 0.58 0.003 LINE L1 0.53 0.52 0.014 LINE L1 0.54 0.52 0.025 LINE L1 0.60 0.59 0.016 LINE L1 0.55 0.54 0.017 LINE L1 0.62 0.60 0.018 LINE L1 0.60 0.59 0.019 LINE L1 0.67 0.66 0.0010 LINE L1 0.63 0.62 0.0211 LINE L1 0.57 0.55 0.0112 LINE L1 0.57 0.55 0.0213 LINE L1 0.58 0.56 0.0114 LINE L1 0.56 0.54 0.0215 LINE L1 0.66 0.65 0.0116 LINE L1 0.66 0.65 0.0117 LINE L1 0.69 0.66 0.0318 LINE L1 0.58 0.56 0.0219 LINE L1 0.63 0.61 0.0220 LINE L1 0.56 0.56 0.0021 LINE L1 0.54 0.53 0.0222 LINE L1 0.64 0.61 0.02X LINE L1 0.63 0.61 0.021 LINE L2 0.74 0.72 0.022 LINE L2 0.72 0.72 0.003 LINE L2 0.65 0.62 0.024 LINE L2 0.62 0.65 D0.035 LINE L2 0.76 0.73 0.046 LINE L2 0.69 0.68 0.027 LINE L2 0.72 0.70 0.028 LINE L2 0.71 0.71 0.009 LINE L2 0.69 0.69 0.0010 LINE L2 0.72 0.72 0.0111 LINE L2 0.69 0.66 0.0312 LINE L2 0.66 0.68 D0.0213 LINE L2 0.66 0.62 0.0314 LINE L2 0.63 0.57 0.0515 LINE L2 0.74 0.70 0.04

16 LINE L2 0.70 0.67 0.0317 LINE L2 0.70 0.67 0.0418 LINE L2 0.53 0.58 D0.0519 LINE L2 0.66 0.63 0.0320 LINE L2 0.62 0.60 0.0121 LINE L2 0.43 0.44 D0.0122 LINE L2 0.67 0.64 0.03X LINE L2 0.70 0.69 0.011 LINE RTE 0.65 0.64 0.012 LINE RTE 0.74 0.77 D0.033 LINE RTE 0.59 0.51 0.084 LINE RTE 0.83 0.78 0.055 LINE RTE 0.78 0.77 0.016 LINE RTE 0.71 0.70 0.007 LINE RTE 0.74 0.67 0.078 LINE RTE 0.82 0.87 D0.059 LINE RTE 0.66 0.73 D0.0710 LINE RTE 0.59 0.71 D0.1211 LINE RTE 0.91 0.88 0.0212 LINE RTE 0.85 0.76 0.0813 LINE RTE 0.00 0.25 D0.2514 LINE RTE 0.34 0.61 D0.2715 LINE RTE 0.73 0.73 0.0016 LINE RTE 0.89 0.85 0.0417 LINE RTE 0.86 0.59 0.2818 LINE RTE 0.00 1.00 D1.0019 LINE RTE 1.00 0.96 0.0421 LINE RTE 0.61 0.69 D0.0722 LINE RTE 0.82 0.72 0.10X LINE RTE 0.70 0.66 0.042 LTR ERV 0.57 0.57 0.0010 LTR ERV 0.79 0.87 D0.0815 LTR ERV 0.76 0.71 0.0516 LTR ERV 0.41 0.37 0.0422 LTR ERV 0.74 0.58 0.16X LTR ERV 0.81 0.79 0.021 LTR ERV1 0.64 0.61 0.022 LTR ERV1 0.61 0.59 0.023 LTR ERV1 0.57 0.54 0.034 LTR ERV1 0.58 0.55 0.025 LTR ERV1 0.63 0.60 0.036 LTR ERV1 0.59 0.57 0.027 LTR ERV1 0.64 0.61 0.038 LTR ERV1 0.64 0.62 0.029 LTR ERV1 0.68 0.66 0.0110 LTR ERV1 0.65 0.62 0.04

11 LTR ERV1 0.61 0.58 0.0312 LTR ERV1 0.61 0.58 0.0313 LTR ERV1 0.63 0.59 0.0314 LTR ERV1 0.57 0.53 0.0415 LTR ERV1 0.65 0.62 0.0316 LTR ERV1 0.65 0.61 0.0317 LTR ERV1 0.64 0.60 0.0318 LTR ERV1 0.58 0.59 0.0019 LTR ERV1 0.59 0.59 0.0120 LTR ERV1 0.58 0.57 0.0121 LTR ERV1 0.57 0.56 0.0122 LTR ERV1 0.59 0.57 0.02X LTR ERV1 0.64 0.60 0.031 LTR ERVK 0.52 0.52 0.002 LTR ERVK 0.54 0.52 0.013 LTR ERVK 0.51 0.54 D0.034 LTR ERVK 0.54 0.52 0.025 LTR ERVK 0.58 0.55 0.026 LTR ERVK 0.51 0.50 0.027 LTR ERVK 0.54 0.53 0.008 LTR ERVK 0.61 0.61 0.009 LTR ERVK 0.62 0.59 0.0310 LTR ERVK 0.55 0.55 0.0011 LTR ERVK 0.49 0.52 D0.0412 LTR ERVK 0.53 0.53 D0.0113 LTR ERVK 0.44 0.46 D0.0214 LTR ERVK 0.51 0.51 0.0015 LTR ERVK 0.57 0.53 0.0416 LTR ERVK 0.63 0.58 0.0517 LTR ERVK 0.55 0.55 0.0118 LTR ERVK 0.49 0.46 0.0319 LTR ERVK 0.52 0.52 0.0020 LTR ERVK 0.51 0.52 D0.0121 LTR ERVK 0.48 0.52 D0.0422 LTR ERVK 0.55 0.57 D0.01X LTR ERVK 0.56 0.56 0.001 LTR ERVL 0.69 0.68 0.012 LTR ERVL 0.69 0.63 0.063 LTR ERVL 0.69 0.63 0.064 LTR ERVL 0.55 0.51 0.045 LTR ERVL 0.69 0.63 0.066 LTR ERVL 0.60 0.50 0.097 LTR ERVL 0.69 0.65 0.048 LTR ERVL 0.65 0.59 0.069 LTR ERVL 0.67 0.66 0.0010 LTR ERVL 0.69 0.66 0.03

11 LTR ERVL 0.60 0.58 0.0212 LTR ERVL 0.62 0.52 0.1013 LTR ERVL 0.68 0.61 0.0714 LTR ERVL 0.51 0.47 0.0515 LTR ERVL 0.70 0.71 0.0016 LTR ERVL 0.66 0.64 0.0217 LTR ERVL 0.61 0.61 0.0118 LTR ERVL 0.48 0.48 0.0019 LTR ERVL 0.54 0.50 0.0320 LTR ERVL 0.63 0.62 0.0121 LTR ERVL 0.53 0.56 D0.0322 LTR ERVL 0.65 0.64 0.01X LTR ERVL 0.68 0.64 0.041 LTR ERVLDMaLR 0.63 0.60 0.032 LTR ERVLDMaLR 0.67 0.66 0.013 LTR ERVLDMaLR 0.45 0.41 0.044 LTR ERVLDMaLR 0.48 0.44 0.045 LTR ERVLDMaLR 0.76 0.73 0.036 LTR ERVLDMaLR 0.53 0.51 0.017 LTR ERVLDMaLR 0.72 0.65 0.068 LTR ERVLDMaLR 0.67 0.61 0.069 LTR ERVLDMaLR 0.70 0.69 0.0110 LTR ERVLDMaLR 0.72 0.69 0.0311 LTR ERVLDMaLR 0.60 0.52 0.0812 LTR ERVLDMaLR 0.65 0.57 0.0813 LTR ERVLDMaLR 0.61 0.52 0.0914 LTR ERVLDMaLR 0.54 0.45 0.0915 LTR ERVLDMaLR 0.71 0.69 0.0116 LTR ERVLDMaLR 0.67 0.66 0.0217 LTR ERVLDMaLR 0.74 0.71 0.0318 LTR ERVLDMaLR 0.54 0.47 0.0719 LTR ERVLDMaLR 0.69 0.63 0.0620 LTR ERVLDMaLR 0.49 0.41 0.0821 LTR ERVLDMaLR 0.44 0.43 0.0122 LTR ERVLDMaLR 0.55 0.54 0.01X LTR ERVLDMaLR 0.71 0.67 0.041 LTR Gypsy 0.57 0.52 0.052 LTR Gypsy 0.72 0.73 D0.013 LTR Gypsy 0.70 0.63 0.064 LTR Gypsy 0.59 0.77 D0.195 LTR Gypsy 0.83 0.00 0.836 LTR Gypsy 0.48 0.52 D0.047 LTR Gypsy 0.63 0.66 D0.038 LTR Gypsy 0.85 0.56 0.299 LTR Gypsy 0.67 0.66 0.0110 LTR Gypsy 0.78 0.82 D0.04

11 LTR Gypsy 0.66 0.55 0.1212 LTR Gypsy 0.81 0.63 0.1813 LTR Gypsy 0.18 0.00 0.1814 LTR Gypsy 0.71 0.66 0.0515 LTR Gypsy 0.56 0.58 D0.0216 LTR Gypsy 0.74 0.86 D0.1317 LTR Gypsy 0.72 0.70 0.0218 LTR Gypsy 0.47 0.47 0.0021 LTR Gypsy 0.63 0.62 0.0122 LTR Gypsy 0.89 0.74 0.14X LTR Gypsy 0.70 0.61 0.091 LTR LTR 0.76 0.73 0.022 LTR LTR 0.39 0.41 D0.015 LTR LTR 0.53 0.54 0.007 LTR LTR 0.75 0.65 0.109 LTR LTR 0.64 0.63 0.0115 LTR LTR 0.59 0.43 0.1616 LTR LTR 0.74 0.66 0.0817 LTR LTR 0.74 0.56 0.1819 LTR LTR 0.61 0.45 0.16X LTR LTR 0.25 0.18 0.073 RC Helitron 0.71 0.71 0.004 RC Helitron 0.85 0.71 0.148 RC Helitron 0.87 0.77 0.109 RC Helitron 0.65 0.80 D0.1410 RC Helitron 0.59 0.46 0.1311 RC Helitron 0.67 0.68 D0.0212 RC Helitron 0.80 0.40 0.4015 RC Helitron 0.92 0.89 0.0316 RC Helitron 0.69 0.69 0.00X RC Helitron 0.92 0.87 0.051 SINE Alu 0.68 0.61 0.082 SINE Alu 0.70 0.62 0.083 SINE Alu 0.65 0.57 0.084 SINE Alu 0.67 0.59 0.085 SINE Alu 0.75 0.65 0.096 SINE Alu 0.66 0.57 0.097 SINE Alu 0.76 0.69 0.078 SINE Alu 0.70 0.61 0.099 SINE Alu 0.76 0.69 0.0610 SINE Alu 0.74 0.65 0.0911 SINE Alu 0.66 0.58 0.0812 SINE Alu 0.63 0.55 0.0813 SINE Alu 0.67 0.58 0.0914 SINE Alu 0.63 0.55 0.0715 SINE Alu 0.75 0.67 0.09

16 SINE Alu 0.76 0.69 0.0717 SINE Alu 0.72 0.62 0.1018 SINE Alu 0.67 0.59 0.0819 SINE Alu 0.63 0.56 0.0820 SINE Alu 0.63 0.55 0.0821 SINE Alu 0.62 0.57 0.0522 SINE Alu 0.69 0.62 0.07X SINE Alu 0.71 0.62 0.091 SINE Deu 0.00 0.00 0.003 SINE Deu 0.16 0.45 D0.301 SINE MIR 0.72 0.71 0.012 SINE MIR 0.70 0.68 0.023 SINE MIR 0.67 0.66 0.014 SINE MIR 0.62 0.58 0.045 SINE MIR 0.73 0.74 D0.016 SINE MIR 0.60 0.68 D0.087 SINE MIR 0.70 0.69 0.008 SINE MIR 0.77 0.77 0.009 SINE MIR 0.71 0.69 0.0210 SINE MIR 0.77 0.74 0.0311 SINE MIR 0.69 0.70 0.0012 SINE MIR 0.70 0.67 0.0313 SINE MIR 0.64 0.61 0.0314 SINE MIR 0.63 0.64 D0.0115 SINE MIR 0.73 0.73 0.0016 SINE MIR 0.72 0.69 0.0317 SINE MIR 0.72 0.71 0.0118 SINE MIR 0.59 0.61 D0.0219 SINE MIR 0.66 0.69 D0.0320 SINE MIR 0.51 0.53 D0.0221 SINE MIR 0.57 0.59 D0.0222 SINE MIR 0.69 0.67 0.02X SINE MIR 0.71 0.70 0.001 SINE tRNADlike 0.81 0.73 0.088 SINE tRNADlike 0.81 0.76 0.0513 SINE tRNADlike 0.19 0.25 D0.0618 SINE tRNADlike 0.18 0.24 D0.0621 SINE tRNADlike 0.18 0.25 D0.07

Repeated non-coding RNA genesChromosome Type Methylation&



1 rRNA 0.63 0.61 0.022 rRNA 0.45 0.38 0.07

5 rRNA 0.90 0.91 D0.016 rRNA 0.34 0.04 0.317 rRNA 0.50 0.44 0.068 rRNA 0.77 0.60 0.179 rRNA 0.56 0.41 0.1610 rRNA 0.93 0.92 0.0111 rRNA 0.35 0.36 0.0012 rRNA 0.55 0.32 0.2314 rRNA 0.08 0.08 0.0016 rRNA 0.68 0.26 0.4217 rRNA 0.74 0.60 0.1418 rRNA 0.06 0.11 D0.0519 rRNA 0.06 0.24 D0.1821 rRNA 0.53 0.34 0.19X rRNA 0.82 0.82 0.012 scRNA 0.75 0.76 D0.017 scRNA 0.84 0.84 D0.019 scRNA 0.84 0.77 0.0711 scRNA 0.94 0.97 D0.0216 scRNA 0.82 0.75 0.0717 scRNA 0.95 0.91 0.0420 scRNA 0.78 0.75 0.03X scRNA 0.85 0.72 0.131 snRNA 0.24 0.23 0.012 snRNA 0.72 0.62 0.103 snRNA 0.65 0.41 0.244 snRNA 0.59 0.51 0.095 snRNA 0.84 0.69 0.146 snRNA 0.19 0.06 0.137 snRNA 0.51 0.52 D0.019 snRNA 0.67 0.67 0.0010 snRNA 0.69 0.82 D0.1211 snRNA 0.67 0.34 0.3314 snRNA 0.48 0.44 0.0415 snRNA 0.69 0.72 D0.0216 snRNA 0.78 0.69 0.0917 snRNA 0.01 0.00 0.0118 snRNA 0.74 0.85 D0.1119 snRNA 0.64 0.43 0.2121 snRNA 0.76 0.80 D0.0422 snRNA 0.73 0.78 D0.04X snRNA 0.45 0.44 0.011 srpRNA 0.85 0.93 D0.084 srpRNA 0.59 0.39 0.209 srpRNA 0.70 0.66 0.0410 srpRNA 0.76 0.74 0.02

14 srpRNA 0.14 0.28 D0.1415 srpRNA 0.80 0.81 D0.0116 srpRNA 0.79 0.75 0.0517 srpRNA 0.90 0.89 0.0219 srpRNA 1.00 0.81 0.1921 srpRNA 0.40 0.40 0.001 tRNA 0.42 0.40 0.024 tRNA 0.75 0.81 D0.065 tRNA 0.16 0.18 D0.026 tRNA 0.36 0.37 D0.019 tRNA 0.64 0.60 0.0417 tRNA 0.90 0.97 D0.0718 tRNA 0.65 1.00 D0.3520 tRNA 0.52 0.47 0.05X tRNA 0.87 0.87 0.00

CHG&methylationSatellite&DNAChromosome Subtype Methylation&



10 Centromere 0.013 0.016 D0.00315 Centromere 0.009 0.012 D0.0028 Centromere 0.009 0.011 D0.0026 Centromere 0.006 0.008 D0.00118 Centromere 0.012 0.013 D0.0015 Centromere 0.009 0.010 D0.0017 Centromere 0.007 0.008 0.0002 Centromere 0.012 0.012 0.00011 Centromere 0.008 0.007 0.00016 Centromere 0.009 0.008 0.00114 Centromere 0.007 0.006 0.0013 Centromere 0.010 0.010 0.00112 Centromere 0.010 0.009 0.00119 Centromere 0.009 0.008 0.0014 Centromere 0.006 0.005 0.0011 Centromere 0.007 0.006 0.0019 Centromere 0.009 0.007 0.00117 Centromere 0.005 0.003 0.00220 Centromere 0.010 0.008 0.002X Centromere 0.011 0.008 0.00322 Centromere 0.007 0.003 0.00321 Centromere 0.011 0.008 0.0035 Generic 0.013 0.032 D0.02012 Generic 0.001 0.012 D0.011

2 Generic 0.020 0.027 D0.00715 Generic 0.000 0.007 D0.0077 Generic 0.029 0.032 D0.0033 Generic 0.008 0.010 D0.00214 Generic 0.003 0.004 D0.00118 Generic 0.006 0.006 D0.00116 Generic 0.027 0.027 0.00022 Generic 0.019 0.018 0.00111 Generic 0.007 0.006 0.00120 Generic 0.009 0.007 0.0018 Generic 0.007 0.006 0.00113 Generic 0.003 0.001 0.0026 Generic 0.002 0.000 0.00219 Generic 0.004 0.001 0.0039 Generic 0.006 0.003 0.0034 Generic 0.031 0.027 0.0041 Generic 0.013 0.009 0.00410 Generic 0.035 0.031 0.00521 Generic 0.014 0.007 0.00717 Generic 0.067 0.005 0.06217 Telomere 0.004 0.013 D0.01013 Telomere 0.011 0.018 D0.00722 Telomere 0.009 0.014 D0.00511 Telomere 0.007 0.010 D0.0037 Telomere 0.006 0.006 0.00020 Telomere 0.002 0.002 0.001X Telomere 0.003 0.003 0.0016 Telomere 0.004 0.003 0.0012 Telomere 0.006 0.005 0.0018 Telomere 0.004 0.002 0.0029 Telomere 0.008 0.006 0.00216 Telomere 0.009 0.007 0.0021 Telomere 0.008 0.006 0.00221 Telomere 0.012 0.010 0.00212 Telomere 0.003 0.001 0.0024 Telomere 0.006 0.004 0.00219 Telomere 0.007 0.004 0.00314 Telomere 0.004 0.001 0.00310 Telomere 0.010 0.007 0.00315 Telomere 0.007 0.004 0.0035 Telomere 0.011 0.006 0.00518 Telomere 0.016 0.008 0.008

Transposons

Chromosome Type Subtype Methylation&level&in&93A

Methylation&level&in&93N


1 DNA DNA 0.001 0.000 0.0014 DNA DNA 0.000 0.000 0.0006 DNA DNA 0.000 0.000 0.0007 DNA DNA 0.002 0.004 D0.0029 DNA DNA 0.002 0.000 0.00210 DNA DNA 0.019 0.001 0.01811 DNA DNA 0.004 0.004 0.00017 DNA DNA 0.003 0.002 0.001X DNA DNA 0.001 0.000 0.0011 DNA hAT 0.011 0.001 0.0102 DNA hAT 0.014 0.001 0.0123 DNA hAT 0.010 0.005 0.0054 DNA hAT 0.002 0.007 D0.0065 DNA hAT 0.006 0.000 0.0066 DNA hAT 0.000 0.001 D0.0017 DNA hAT 0.006 0.002 0.0048 DNA hAT 0.004 0.002 0.0029 DNA hAT 0.005 0.001 0.00410 DNA hAT 0.003 0.004 D0.00111 DNA hAT 0.001 0.000 0.00112 DNA hAT 0.012 0.001 0.01113 DNA hAT 0.008 0.000 0.00814 DNA hAT 0.003 0.002 0.00115 DNA hAT 0.003 0.002 0.00116 DNA hAT 0.004 0.001 0.00217 DNA hAT 0.005 0.001 0.00418 DNA hAT 0.002 0.000 0.00219 DNA hAT 0.003 0.007 D0.00420 DNA hAT 0.004 0.003 0.00121 DNA hAT 0.001 0.000 0.00122 DNA hAT 0.006 0.003 0.003X DNA hAT 0.004 0.006 D0.0011 DNA hATDBlackjack 0.003 0.001 0.0012 DNA hATDBlackjack 0.005 0.004 0.0023 DNA hATDBlackjack 0.010 0.006 0.0044 DNA hATDBlackjack 0.008 0.006 0.0025 DNA hATDBlackjack 0.004 0.001 0.0036 DNA hATDBlackjack 0.013 0.001 0.0127 DNA hATDBlackjack 0.011 0.008 0.0048 DNA hATDBlackjack 0.000 0.000 0.0009 DNA hATDBlackjack 0.003 0.004 D0.00110 DNA hATDBlackjack 0.005 0.003 0.003

11 DNA hATDBlackjack 0.006 0.006 0.00012 DNA hATDBlackjack 0.008 0.000 0.00813 DNA hATDBlackjack 0.005 0.000 0.00514 DNA hATDBlackjack 0.000 0.000 0.00015 DNA hATDBlackjack 0.006 0.005 0.00116 DNA hATDBlackjack 0.003 0.002 0.00117 DNA hATDBlackjack 0.007 0.001 0.00618 DNA hATDBlackjack 0.002 0.010 D0.00819 DNA hATDBlackjack 0.001 0.005 D0.00320 DNA hATDBlackjack 0.004 0.004 0.00021 DNA hATDBlackjack 0.001 0.001 0.00022 DNA hATDBlackjack 0.003 0.000 0.003X DNA hATDBlackjack 0.002 0.007 D0.0051 DNA hATDCharlie 0.005 0.004 0.0022 DNA hATDCharlie 0.005 0.003 0.0023 DNA hATDCharlie 0.005 0.005 0.0014 DNA hATDCharlie 0.006 0.005 0.0025 DNA hATDCharlie 0.005 0.003 0.0016 DNA hATDCharlie 0.003 0.002 0.0017 DNA hATDCharlie 0.005 0.002 0.0038 DNA hATDCharlie 0.005 0.003 0.0029 DNA hATDCharlie 0.005 0.002 0.00310 DNA hATDCharlie 0.005 0.002 0.00211 DNA hATDCharlie 0.004 0.001 0.00312 DNA hATDCharlie 0.009 0.002 0.00613 DNA hATDCharlie 0.003 0.002 0.00114 DNA hATDCharlie 0.004 0.001 0.00215 DNA hATDCharlie 0.005 0.003 0.00116 DNA hATDCharlie 0.004 0.003 0.00217 DNA hATDCharlie 0.004 0.004 0.00018 DNA hATDCharlie 0.005 0.002 0.00319 DNA hATDCharlie 0.003 0.002 0.00120 DNA hATDCharlie 0.008 0.005 0.00321 DNA hATDCharlie 0.006 0.004 0.00122 DNA hATDCharlie 0.005 0.003 0.002X DNA hATDCharlie 0.004 0.002 0.0021 DNA hATDTip100 0.007 0.005 0.0022 DNA hATDTip100 0.007 0.001 0.0063 DNA hATDTip100 0.001 0.001 0.0004 DNA hATDTip100 0.004 0.002 0.0035 DNA hATDTip100 0.004 0.001 0.0026 DNA hATDTip100 0.011 0.004 0.0087 DNA hATDTip100 0.004 0.005 D0.0018 DNA hATDTip100 0.005 0.002 0.0049 DNA hATDTip100 0.007 0.003 0.00410 DNA hATDTip100 0.003 0.004 0.000

11 DNA hATDTip100 0.009 0.003 0.00612 DNA hATDTip100 0.005 0.007 D0.00213 DNA hATDTip100 0.001 0.002 D0.00214 DNA hATDTip100 0.004 0.004 0.00015 DNA hATDTip100 0.003 0.002 0.00116 DNA hATDTip100 0.007 0.002 0.00617 DNA hATDTip100 0.005 0.001 0.00418 DNA hATDTip100 0.006 0.007 0.00019 DNA hATDTip100 0.004 0.003 0.00020 DNA hATDTip100 0.003 0.002 0.00121 DNA hATDTip100 0.005 0.006 0.00022 DNA hATDTip100 0.006 0.003 0.003X DNA hATDTip100 0.004 0.001 0.0026 DNA Merlin 0.007 0.002 0.0051 DNA MuDR 0.001 0.003 D0.0022 DNA MuDR 0.000 0.000 0.0003 DNA MuDR 0.000 0.000 0.0004 DNA MuDR 0.014 0.013 0.0025 DNA MuDR 0.001 0.002 0.0006 DNA MuDR 0.004 0.001 0.0037 DNA MuDR 0.003 0.001 0.0028 DNA MuDR 0.000 0.001 D0.0019 DNA MuDR 0.010 0.004 0.00610 DNA MuDR 0.000 0.000 0.00011 DNA MuDR 0.008 0.000 0.00815 DNA MuDR 0.005 0.000 0.00517 DNA MuDR 0.001 0.000 0.00018 DNA MuDR 0.000 0.000 0.00021 DNA MuDR 0.000 0.000 0.000X DNA MuDR 0.003 0.001 0.0011 DNA PiggyBac 0.001 0.002 D0.0012 DNA PiggyBac 0.003 0.001 0.0023 DNA PiggyBac 0.001 0.001 0.0005 DNA PiggyBac 0.005 0.002 0.0037 DNA PiggyBac 0.007 0.002 0.0059 DNA PiggyBac 0.016 0.001 0.01510 DNA PiggyBac 0.006 0.000 0.00612 DNA PiggyBac 0.007 0.002 0.00513 DNA PiggyBac 0.003 0.000 0.00314 DNA PiggyBac 0.003 0.002 0.00115 DNA PiggyBac 0.001 0.000 0.00117 DNA PiggyBac 0.002 0.001 0.00119 DNA PiggyBac 0.000 0.000 0.00022 DNA PiggyBac 0.002 0.001 0.0011 DNA TcMar 0.006 0.001 0.0052 DNA TcMar 0.007 0.003 0.004

7 DNA TcMar 0.004 0.001 0.0039 DNA TcMar 0.027 0.001 0.02610 DNA TcMar 0.000 0.002 D0.00117 DNA TcMar 0.000 0.000 0.00022 DNA TcMar 0.007 0.001 0.0061 DNA TcMarDMariner 0.004 0.001 0.0022 DNA TcMarDMariner 0.006 0.001 0.0053 DNA TcMarDMariner 0.003 0.003 0.0004 DNA TcMarDMariner 0.003 0.003 0.0005 DNA TcMarDMariner 0.004 0.003 0.0007 DNA TcMarDMariner 0.007 0.001 0.0068 DNA TcMarDMariner 0.004 0.003 0.0019 DNA TcMarDMariner 0.006 0.005 0.00010 DNA TcMarDMariner 0.011 0.007 0.00511 DNA TcMarDMariner 0.001 0.001 0.00012 DNA TcMarDMariner 0.016 0.001 0.01513 DNA TcMarDMariner 0.001 0.001 0.00114 DNA TcMarDMariner 0.003 0.000 0.00315 DNA TcMarDMariner 0.009 0.006 0.00316 DNA TcMarDMariner 0.004 0.003 0.00117 DNA TcMarDMariner 0.001 0.000 0.00118 DNA TcMarDMariner 0.003 0.003 0.00019 DNA TcMarDMariner 0.000 0.000 0.00020 DNA TcMarDMariner 0.003 0.003 0.00021 DNA TcMarDMariner 0.013 0.003 0.01022 DNA TcMarDMariner 0.001 0.001 0.000X DNA TcMarDMariner 0.003 0.005 D0.0021 DNA TcMarDTc2 0.004 0.004 0.0002 DNA TcMarDTc2 0.003 0.007 D0.0043 DNA TcMarDTc2 0.006 0.004 0.0034 DNA TcMarDTc2 0.006 0.001 0.0055 DNA TcMarDTc2 0.003 0.002 0.0006 DNA TcMarDTc2 0.003 0.001 0.0027 DNA TcMarDTc2 0.005 0.000 0.0048 DNA TcMarDTc2 0.003 0.006 D0.0039 DNA TcMarDTc2 0.012 0.005 0.00710 DNA TcMarDTc2 0.006 0.000 0.00611 DNA TcMarDTc2 0.010 0.000 0.01012 DNA TcMarDTc2 0.006 0.000 0.00613 DNA TcMarDTc2 0.005 0.000 0.00514 DNA TcMarDTc2 0.013 0.008 0.00515 DNA TcMarDTc2 0.008 0.002 0.00616 DNA TcMarDTc2 0.004 0.002 0.00217 DNA TcMarDTc2 0.000 0.000 0.00018 DNA TcMarDTc2 0.004 0.009 D0.00521 DNA TcMarDTc2 0.018 0.006 0.012

22 DNA TcMarDTc2 0.008 0.000 0.008X DNA TcMarDTc2 0.002 0.000 0.0021 DNA TcMarDTigger 0.006 0.004 0.0022 DNA TcMarDTigger 0.005 0.003 0.0023 DNA TcMarDTigger 0.010 0.002 0.0084 DNA TcMarDTigger 0.007 0.009 D0.0035 DNA TcMarDTigger 0.005 0.004 0.0016 DNA TcMarDTigger 0.005 0.004 0.0017 DNA TcMarDTigger 0.005 0.003 0.0028 DNA TcMarDTigger 0.004 0.003 0.0019 DNA TcMarDTigger 0.006 0.003 0.00310 DNA TcMarDTigger 0.006 0.002 0.00411 DNA TcMarDTigger 0.006 0.005 0.00212 DNA TcMarDTigger 0.004 0.003 0.00113 DNA TcMarDTigger 0.004 0.003 0.00114 DNA TcMarDTigger 0.004 0.005 0.00015 DNA TcMarDTigger 0.004 0.003 0.00216 DNA TcMarDTigger 0.006 0.003 0.00317 DNA TcMarDTigger 0.005 0.003 0.00218 DNA TcMarDTigger 0.004 0.008 D0.00419 DNA TcMarDTigger 0.008 0.004 0.00420 DNA TcMarDTigger 0.012 0.011 0.00121 DNA TcMarDTigger 0.007 0.007 0.00022 DNA TcMarDTigger 0.005 0.002 0.003X DNA TcMarDTigger 0.004 0.002 0.0021 LINE CR1 0.005 0.003 0.0022 LINE CR1 0.006 0.004 0.0013 LINE CR1 0.001 0.000 0.0014 LINE CR1 0.006 0.001 0.0055 LINE CR1 0.003 0.002 0.0026 LINE CR1 0.004 0.001 0.0037 LINE CR1 0.004 0.003 0.0018 LINE CR1 0.003 0.001 0.0029 LINE CR1 0.007 0.003 0.00310 LINE CR1 0.005 0.009 D0.00311 LINE CR1 0.004 0.001 0.00312 LINE CR1 0.006 0.007 D0.00113 LINE CR1 0.000 0.001 0.00014 LINE CR1 0.007 0.011 D0.00415 LINE CR1 0.005 0.002 0.00316 LINE CR1 0.003 0.002 0.00117 LINE CR1 0.006 0.002 0.00318 LINE CR1 0.005 0.010 D0.00519 LINE CR1 0.033 0.003 0.03020 LINE CR1 0.002 0.004 D0.00321 LINE CR1 0.003 0.001 0.002

22 LINE CR1 0.002 0.003 D0.001X LINE CR1 0.003 0.002 0.0013 LINE DongDR4 0.000 0.000 0.00017 LINE DongDR4 0.004 0.006 D0.0021 LINE L1 0.007 0.005 0.0022 LINE L1 0.007 0.005 0.0023 LINE L1 0.007 0.005 0.0024 LINE L1 0.007 0.005 0.0025 LINE L1 0.007 0.005 0.0026 LINE L1 0.007 0.005 0.0027 LINE L1 0.006 0.004 0.0028 LINE L1 0.007 0.005 0.0029 LINE L1 0.006 0.004 0.00310 LINE L1 0.006 0.004 0.00211 LINE L1 0.007 0.004 0.00312 LINE L1 0.007 0.005 0.00313 LINE L1 0.007 0.004 0.00214 LINE L1 0.007 0.005 0.00215 LINE L1 0.006 0.004 0.00216 LINE L1 0.006 0.004 0.00317 LINE L1 0.006 0.004 0.00218 LINE L1 0.006 0.005 0.00219 LINE L1 0.006 0.004 0.00220 LINE L1 0.007 0.004 0.00321 LINE L1 0.006 0.004 0.00222 LINE L1 0.008 0.004 0.003X LINE L1 0.006 0.004 0.0021 LINE L2 0.005 0.003 0.0022 LINE L2 0.006 0.004 0.0023 LINE L2 0.006 0.005 0.0014 LINE L2 0.007 0.002 0.0045 LINE L2 0.005 0.001 0.0036 LINE L2 0.005 0.002 0.0037 LINE L2 0.005 0.003 0.0028 LINE L2 0.005 0.003 0.0029 LINE L2 0.005 0.003 0.00210 LINE L2 0.005 0.002 0.00311 LINE L2 0.004 0.002 0.00212 LINE L2 0.006 0.004 0.00213 LINE L2 0.003 0.002 0.00114 LINE L2 0.005 0.002 0.00315 LINE L2 0.004 0.002 0.00216 LINE L2 0.005 0.002 0.00217 LINE L2 0.004 0.002 0.00218 LINE L2 0.003 0.002 0.00119 LINE L2 0.005 0.003 0.002

20 LINE L2 0.005 0.004 0.00121 LINE L2 0.004 0.003 0.00122 LINE L2 0.005 0.002 0.003X LINE L2 0.003 0.002 0.0021 LINE RTE 0.004 0.003 0.0022 LINE RTE 0.006 0.001 0.0053 LINE RTE 0.002 0.001 0.0014 LINE RTE 0.002 0.001 0.0015 LINE RTE 0.003 0.003 0.0006 LINE RTE 0.002 0.002 0.0007 LINE RTE 0.003 0.004 D0.0018 LINE RTE 0.005 0.002 0.0039 LINE RTE 0.004 0.002 0.00210 LINE RTE 0.005 0.005 D0.00111 LINE RTE 0.003 0.012 D0.00912 LINE RTE 0.002 0.001 0.00013 LINE RTE 0.000 0.000 0.00014 LINE RTE 0.003 0.000 0.00315 LINE RTE 0.003 0.002 0.00216 LINE RTE 0.003 0.001 0.00217 LINE RTE 0.005 0.002 0.00318 LINE RTE 0.001 0.000 0.00119 LINE RTE 0.008 0.002 0.00721 LINE RTE 0.002 0.001 0.00122 LINE RTE 0.007 0.002 0.005X LINE RTE 0.003 0.003 0.0006 LINE RTEDBovB 0.000 0.000 0.0002 LTR ERV 0.005 0.001 0.00410 LTR ERV 0.007 0.005 0.00315 LTR ERV 0.003 0.003 0.00016 LTR ERV 0.003 0.003 0.00022 LTR ERV 0.000 0.003 D0.003X LTR ERV 0.002 0.001 0.0021 LTR ERV1 0.006 0.005 0.0012 LTR ERV1 0.006 0.005 0.0013 LTR ERV1 0.008 0.007 0.0014 LTR ERV1 0.007 0.006 0.0015 LTR ERV1 0.007 0.005 0.0016 LTR ERV1 0.006 0.007 0.0007 LTR ERV1 0.006 0.006 0.0018 LTR ERV1 0.009 0.006 0.0039 LTR ERV1 0.006 0.004 0.00210 LTR ERV1 0.006 0.005 0.00111 LTR ERV1 0.006 0.006 0.00012 LTR ERV1 0.007 0.006 0.00013 LTR ERV1 0.008 0.007 0.001

14 LTR ERV1 0.006 0.005 0.00115 LTR ERV1 0.006 0.004 0.00116 LTR ERV1 0.006 0.003 0.00317 LTR ERV1 0.006 0.004 0.00218 LTR ERV1 0.006 0.005 0.00019 LTR ERV1 0.005 0.006 0.00020 LTR ERV1 0.006 0.006 0.00021 LTR ERV1 0.006 0.004 0.00222 LTR ERV1 0.007 0.005 0.001X LTR ERV1 0.006 0.005 0.0011 LTR ERVK 0.006 0.007 D0.0012 LTR ERVK 0.007 0.010 D0.0033 LTR ERVK 0.009 0.007 0.0024 LTR ERVK 0.008 0.007 0.0015 LTR ERVK 0.007 0.004 0.0026 LTR ERVK 0.008 0.006 0.0027 LTR ERVK 0.008 0.005 0.0038 LTR ERVK 0.008 0.005 0.0029 LTR ERVK 0.007 0.006 0.00110 LTR ERVK 0.008 0.007 0.00111 LTR ERVK 0.008 0.008 0.00012 LTR ERVK 0.006 0.007 D0.00113 LTR ERVK 0.005 0.007 D0.00114 LTR ERVK 0.006 0.007 D0.00115 LTR ERVK 0.007 0.005 0.00116 LTR ERVK 0.008 0.006 0.00217 LTR ERVK 0.006 0.004 0.00218 LTR ERVK 0.015 0.006 0.00919 LTR ERVK 0.008 0.007 0.00120 LTR ERVK 0.006 0.006 0.00021 LTR ERVK 0.007 0.007 0.00022 LTR ERVK 0.009 0.004 0.005X LTR ERVK 0.007 0.006 0.0011 LTR ERVL 0.006 0.004 0.0022 LTR ERVL 0.006 0.004 0.0023 LTR ERVL 0.005 0.005 0.0014 LTR ERVL 0.007 0.005 0.0025 LTR ERVL 0.005 0.004 0.0016 LTR ERVL 0.006 0.004 0.0027 LTR ERVL 0.004 0.003 0.0028 LTR ERVL 0.004 0.003 0.0029 LTR ERVL 0.004 0.002 0.00210 LTR ERVL 0.004 0.003 0.00111 LTR ERVL 0.005 0.002 0.00312 LTR ERVL 0.006 0.004 0.00213 LTR ERVL 0.008 0.007 0.001

14 LTR ERVL 0.003 0.008 D0.00515 LTR ERVL 0.006 0.003 0.00316 LTR ERVL 0.004 0.002 0.00217 LTR ERVL 0.004 0.003 0.00118 LTR ERVL 0.006 0.004 0.00319 LTR ERVL 0.007 0.003 0.00420 LTR ERVL 0.005 0.004 0.00121 LTR ERVL 0.005 0.004 0.00222 LTR ERVL 0.005 0.003 0.002X LTR ERVL 0.004 0.002 0.0011 LTR ERVLDMaLR 0.005 0.004 0.0012 LTR ERVLDMaLR 0.005 0.003 0.0023 LTR ERVLDMaLR 0.006 0.005 0.0014 LTR ERVLDMaLR 0.006 0.005 0.0015 LTR ERVLDMaLR 0.005 0.003 0.0026 LTR ERVLDMaLR 0.005 0.005 0.0017 LTR ERVLDMaLR 0.005 0.004 0.0018 LTR ERVLDMaLR 0.005 0.004 0.0019 LTR ERVLDMaLR 0.005 0.003 0.00210 LTR ERVLDMaLR 0.008 0.003 0.00411 LTR ERVLDMaLR 0.005 0.004 0.00212 LTR ERVLDMaLR 0.005 0.005 0.00013 LTR ERVLDMaLR 0.004 0.003 0.00014 LTR ERVLDMaLR 0.004 0.004 0.00015 LTR ERVLDMaLR 0.004 0.002 0.00216 LTR ERVLDMaLR 0.004 0.002 0.00217 LTR ERVLDMaLR 0.004 0.002 0.00118 LTR ERVLDMaLR 0.005 0.004 0.00119 LTR ERVLDMaLR 0.005 0.003 0.00220 LTR ERVLDMaLR 0.005 0.005 0.00021 LTR ERVLDMaLR 0.005 0.003 0.00222 LTR ERVLDMaLR 0.004 0.003 0.001X LTR ERVLDMaLR 0.004 0.003 0.0011 LTR Gypsy 0.004 0.003 0.0012 LTR Gypsy 0.003 0.000 0.0033 LTR Gypsy 0.001 0.001 0.0004 LTR Gypsy 0.000 0.001 D0.0015 LTR Gypsy 0.000 0.000 0.0006 LTR Gypsy 0.003 0.002 0.0007 LTR Gypsy 0.003 0.003 0.0008 LTR Gypsy 0.004 0.000 0.0039 LTR Gypsy 0.006 0.011 D0.00610 LTR Gypsy 0.006 0.001 0.00511 LTR Gypsy 0.001 0.001 D0.00112 LTR Gypsy 0.002 0.002 0.00013 LTR Gypsy 0.001 0.000 0.000

14 LTR Gypsy 0.003 0.009 D0.00615 LTR Gypsy 0.006 0.002 0.00516 LTR Gypsy 0.001 0.000 0.00117 LTR Gypsy 0.007 0.000 0.00618 LTR Gypsy 0.004 0.002 0.00121 LTR Gypsy 0.003 0.002 0.00122 LTR Gypsy 0.006 0.001 0.005X LTR Gypsy 0.003 0.009 D0.0051 LTR LTR 0.011 0.003 0.0092 LTR LTR 0.006 0.000 0.0065 LTR LTR 0.010 0.001 0.0086 LTR LTR 0.005 0.003 0.0027 LTR LTR 0.003 0.001 0.0029 LTR LTR 0.004 0.002 0.00212 LTR LTR 0.013 0.000 0.01315 LTR LTR 0.001 0.000 0.00116 LTR LTR 0.001 0.001 0.00017 LTR LTR 0.002 0.000 0.00218 LTR LTR 0.000 0.000 0.00019 LTR LTR 0.001 0.000 0.001X LTR LTR 0.031 0.000 0.0313 RC Helitron 0.001 0.006 D0.0054 RC Helitron 0.003 0.000 0.0038 RC Helitron 0.008 0.009 D0.0029 RC Helitron 0.005 0.002 0.00410 RC Helitron 0.003 0.001 0.00211 RC Helitron 0.003 0.025 D0.02212 RC Helitron 0.002 0.000 0.00215 RC Helitron 0.003 0.002 0.00116 RC Helitron 0.007 0.001 0.006X RC Helitron 0.003 0.000 0.0031 SINE Alu 0.008 0.007 0.0012 SINE Alu 0.008 0.006 0.0013 SINE Alu 0.009 0.007 0.0024 SINE Alu 0.008 0.007 0.0015 SINE Alu 0.007 0.005 0.0016 SINE Alu 0.008 0.007 0.0017 SINE Alu 0.006 0.004 0.0018 SINE Alu 0.008 0.006 0.0029 SINE Alu 0.006 0.005 0.00110 SINE Alu 0.007 0.005 0.00211 SINE Alu 0.008 0.006 0.00112 SINE Alu 0.009 0.007 0.00213 SINE Alu 0.007 0.006 0.00114 SINE Alu 0.007 0.006 0.00115 SINE Alu 0.006 0.005 0.001

16 SINE Alu 0.006 0.004 0.00117 SINE Alu 0.007 0.006 0.00118 SINE Alu 0.008 0.006 0.00119 SINE Alu 0.008 0.007 0.00120 SINE Alu 0.009 0.007 0.00221 SINE Alu 0.008 0.007 0.00122 SINE Alu 0.006 0.005 0.001X SINE Alu 0.006 0.006 0.0011 SINE Deu 0.002 0.002 0.0003 SINE Deu 0.002 0.002 D0.0014 SINE Deu 0.002 0.000 0.0021 SINE MIR 0.006 0.003 0.0032 SINE MIR 0.005 0.003 0.0023 SINE MIR 0.005 0.004 0.0024 SINE MIR 0.005 0.003 0.0025 SINE MIR 0.005 0.003 0.0026 SINE MIR 0.005 0.002 0.0027 SINE MIR 0.005 0.003 0.0028 SINE MIR 0.006 0.002 0.0049 SINE MIR 0.005 0.003 0.00210 SINE MIR 0.005 0.002 0.00311 SINE MIR 0.005 0.003 0.00212 SINE MIR 0.005 0.003 0.00213 SINE MIR 0.006 0.001 0.00414 SINE MIR 0.011 0.002 0.00915 SINE MIR 0.005 0.004 0.00116 SINE MIR 0.005 0.002 0.00317 SINE MIR 0.004 0.003 0.00118 SINE MIR 0.003 0.001 0.00219 SINE MIR 0.003 0.003 0.00120 SINE MIR 0.005 0.004 0.00121 SINE MIR 0.005 0.002 0.00322 SINE MIR 0.004 0.002 0.002X SINE MIR 0.004 0.002 0.0021 SINE SINE 0.009 0.003 0.0067 SINE SINE 0.012 0.003 0.0091 SINE tRNADlike 0.005 0.002 0.0033 SINE tRNADlike 0.004 0.000 0.0046 SINE tRNADlike 0.001 0.000 0.0018 SINE tRNADlike 0.007 0.002 0.00512 SINE tRNADlike 0.000 0.000 0.00013 SINE tRNADlike 0.012 0.003 0.00918 SINE tRNADlike 0.010 0.007 0.00321 SINE tRNADlike 0.003 0.000 0.003X SINE tRNADlike 0.000 0.000 0.000

Repeated non-coding RNA genesChromosome Type Methylation&



1 rRNA 0.008 0.005 0.0022 rRNA 0.010 0.009 0.0015 rRNA 0.000 0.000 0.0006 rRNA 0.003 0.007 D0.0047 rRNA 0.018 0.007 0.0118 rRNA 0.006 0.017 D0.0119 rRNA 0.046 0.004 0.04210 rRNA 0.005 0.001 0.00411 rRNA 0.007 0.004 0.00312 rRNA 0.008 0.003 0.00614 rRNA 0.005 0.005 0.00015 rRNA 0.000 0.000 0.00016 rRNA 0.010 0.005 0.00517 rRNA 0.002 0.003 D0.00118 rRNA 0.000 0.001 D0.00119 rRNA 0.035 0.032 0.00321 rRNA 0.002 0.010 D0.008X rRNA 0.007 0.002 0.0041 scRNA 0.004 0.000 0.0042 scRNA 0.007 0.009 D0.0016 scRNA 0.000 0.000 0.0007 scRNA 0.003 0.011 D0.0089 scRNA 0.003 0.002 0.00111 scRNA 0.001 0.002 0.00014 scRNA 0.002 0.000 0.00215 scRNA 0.000 0.000 0.00016 scRNA 0.001 0.001 0.00017 scRNA 0.002 0.007 D0.00518 scRNA 0.000 0.000 0.00020 scRNA 0.007 0.000 0.00721 scRNA 0.000 0.000 0.000X scRNA 0.000 0.008 D0.0081 snRNA 0.007 0.003 0.0042 snRNA 0.004 0.005 D0.0023 snRNA 0.006 0.000 0.0064 snRNA 0.001 0.000 0.0015 snRNA 0.002 0.002 0.0006 snRNA 0.002 0.000 0.0017 snRNA 0.007 0.000 0.0079 snRNA 0.004 0.004 0.00010 snRNA 0.004 0.005 D0.001

11 snRNA 0.018 0.000 0.01813 snRNA 0.000 0.000 0.00014 snRNA 0.004 0.008 D0.00415 snRNA 0.003 0.001 0.00216 snRNA 0.009 0.002 0.00817 snRNA 0.002 0.000 0.00118 snRNA 0.005 0.000 0.00519 snRNA 0.005 0.000 0.00520 snRNA 0.000 0.000 0.00021 snRNA 0.004 0.005 D0.00122 snRNA 0.002 0.002 0.000X snRNA 0.006 0.002 0.0041 srpRNA 0.001 0.000 0.0012 srpRNA 0.007 0.000 0.0074 srpRNA 0.005 0.006 D0.0016 srpRNA 0.000 0.004 D0.0049 srpRNA 0.004 0.002 0.00310 srpRNA 0.003 0.002 0.00114 srpRNA 0.003 0.003 D0.00115 srpRNA 0.003 0.002 0.00216 srpRNA 0.004 0.003 0.00117 srpRNA 0.002 0.002 0.00019 srpRNA 0.000 0.000 0.00021 srpRNA 0.002 0.001 0.00022 srpRNA 0.004 0.006 D0.0021 tRNA 0.003 0.002 0.0014 tRNA 0.009 0.003 0.0065 tRNA 0.002 0.001 0.0016 tRNA 0.004 0.000 0.0049 tRNA 0.020 0.002 0.01812 tRNA 0.000 0.000 0.00013 tRNA 0.000 0.000 0.00015 tRNA 0.031 0.003 0.02816 tRNA 0.002 0.000 0.00217 tRNA 0.001 0.001 0.00018 tRNA 0.023 0.028 D0.00520 tRNA 0.051 0.057 D0.006X tRNA 0.001 0.002 D0.001

Supplementary Table 4. Validation of putative differentially methylated CpGs and expression analysis _______________________________________________________________________________________________________________________ Pyrosequencing Gene CpG ID Context Delta-Beta Diff. % methylation Sequenced Expression (450k array)¶ A-N (pyrosequencing)§ CpGs (fold A vs. N) _______________________________________________________________________________________________________________________ HOXA2 cg23979631 promoter 0.34 +11.7 3 HOXA6 cg19816811 promoter -0.28 +2.35** HOXA9 cg03217995 body/exon -0.55 -34.4 5 +5.71** HOXA9 cg16913789, cg25188395 body/intron -0.37, -0.46 -27.7, -33.2 6 HOXA11AS cg05311410, cg17466857 body/exon 0.44, 0.35 +15.37, +12.2 7 HOXC4 cg03146625, cg15648389 body/exon 0.60, 0.47 +27.4, +26.3 5 HOXC11 cg23395715 3' UTR 0.35 +9.1 12 HOXC11 cg02384661 3' UTR 0.34 +21.8 3 PDGFA cg14496282 body/intron 0.30 +18.8 6 -6.29** PLAT cg01419713 body/exon 0.30 +28.9 4 +4.68** PRRX1 cg21914290 body/intron -0.28 -26.3 3 +1.51* PXDN cg07608848, cg15796818 body/exon 0.37, 0.34 +23.1, +23.5 5 -1.73* _______________________________________________________________________________________________________________________ Conventional bisulfite sequencing Gene CpG ID Context Delta-Beta average % methylated Sequenced Expression (450k array) clones (n=total no. of clones) CpGs (fold A vs. N) _______________________________________________________________________________________________________________________ MIR23b cg00351472 promoter 0.28 97A: 63.6 (n=6) 11 -2.29** 97N: 10.9 (n=10) _______________________________________________________________________________________________________________________ ¶Initial (discovery) 15 paired aortic samples. §Additional 24 aortic pairs for validation. CpGs entries on the same line were sequenced in the same reaction. Two entries for a gene indicate that two distinct gene portions have been sequenced in separate reactions. For pyrosequencing, within-aortic pair differences were significant at p<0.001 in all cases (Chi-square test). Significance levels: *, ** and ***, 0.05, 0.01 and 0.001 level, respectively.

Supplementary,Table,5.,Atherosclerosis,grade9,,age9,and,sex9independent,aortic,dm9CpGs

TargetID Chr Position Gene Mapping3relative3to3genes Mapping3relative3to3CGI

Average3A7N3Delta3Beta

paired3t7test,3p

cg14171824 1 2,006,656 PRKCZ;PRKCZ Body;5'UTR S_Shore 0.165 3.350E708cg23648809 1 2,106,400 PRKCZ;PRKCZ;PRKCZ Body;Body;Body 0.151 5.906E708cg19846168 1 2,845,268 N_Shore 0.151 1.281E709cg24490279 1 2,997,360 PRDM16;PRDM16 Body;Body Island 0.164 5.712E710cg02330501 1 2,997,409 PRDM16;PRDM16 Body;Body Island 0.191 1.062E710cg10442735 1 3,062,633 PRDM16;PRDM16 Body;Body S_Shelf 0.167 6.951E708cg22009660 1 3,068,360 PRDM16;PRDM16 Body;Body N_Shelf 0.197 9.184E711cg05265611 1 3,129,633 PRDM16;PRDM16 Body;Body 0.188 4.439E708cg01940181 1 3,135,712 PRDM16;PRDM16 Body;Body 0.229 1.189E710cg09282201 1 3,155,161 PRDM16;PRDM16 Body;Body Island 0.186 3.166E708cg22730864 1 3,161,448 PRDM16;PRDM16 Body;Body N_Shelf 0.177 1.598E708cg16429975 1 6,445,632 ACOT7;ACOT7 Body;1stExon 0.235 3.569E709cg15205428 1 6,526,051 TNFRSF25;TNFRSF25;TNFRSF25;TNFRSF25;TNFRSF25;TNFRSF25Body;Body;Body;Body;Body;Body Island 70.169 4.302E708cg02993722 1 6,698,457 DNAJC11 Body 0.153 3.110E708cg01535838 1 7,102,397 CAMTA1 Body 0.216 8.286E708cg04492086 1 8,173,451 0.171 1.860E711cg11080552 1 8,556,722 RERE;RERE Body;Body 0.166 1.528E709cg20416874 1 8,611,966 RERE;RERE Body;Body 0.158 3.034E708cg27230594 1 8,908,794 0.152 4.507E708cg13225830 1 9,527,173 0.235 2.282E708cg13683667 1 9,527,208 0.180 1.671E710cg20488341 1 9,896,309 0.157 8.955E709cg20163085 1 10,510,396 CORT;APITD1 Body;Body 0.203 5.358E709cg06377684 1 10,700,647 CASZ1 Body N_Shore 0.166 6.955E708cg22728186 1 10,712,967 CASZ1;CASZ1 Body;Body N_Shore 0.154 7.817E709cg20288000 1 10,735,169 CASZ1;CASZ1 Body;Body 0.190 1.236E710cg07922924 1 11,211,274 MTOR Body 0.171 9.193E708cg07155422 1 12,114,402 0.202 4.040E709cg09518518 1 12,703,968 AADACL4 TSS1500 0.180 1.376E708cg06751920 1 12,704,007 AADACL4 TSS1500 0.187 9.799E708cg24597131 1 15,354,730 KIAA1026;KIAA1026;KIAA1026;KIAA1026;KIAA1026Body;Body;Body;Body;Body 0.161 2.585E709cg06207778 1 15,672,633 FHAD1 Body 70.156 1.700E708cg00025357 1 17,577,455 PADI3 Body 70.155 7.239E711cg10115348 1 17,865,653 ARHGEF10L TSS1500 N_Shore 0.189 7.512E710cg16171105 1 18,205,396 0.193 2.542E709cg05766605 1 19,384,827 0.167 7.083E708cg15964018 1 19,490,180 UBR4 Body 0.196 5.764E709cg17786902 1 19,740,722 CAPZB Body 0.163 6.363E708cg24439190 1 19,741,833 CAPZB Body 0.226 1.613E709cg13319175 1 19,746,564 CAPZB Body 0.195 4.549E708cg03517918 1 19,946,398 C1orf151 Body 0.216 3.935E709cg16054502 1 22,224,163 HSPG2 Body 0.153 4.460E708cg05663453 1 22,782,452 ZBTB40;ZBTB40 5'UTR;5'UTR S_Shelf 0.274 2.077E709cg24364723 1 22,838,414 ZBTB40;ZBTB40 Body;Body 0.238 2.074E708cg02974898 1 23,105,600 EPHB2;EPHB2 Body;Body 0.186 9.898E710cg13988448 1 23,115,536 EPHB2;EPHB2 Body;Body S_Shelf 0.156 6.321E708cg22931642 1 23,135,043 EPHB2;EPHB2 Body;Body 0.172 7.740E710cg18156963 1 23,153,308 EPHB2;EPHB2 Body;Body 0.150 1.490E709cg03106717 1 25,152,974 CLIC4 Body 0.209 5.589E708cg16177693 1 27,240,669 NR0B2 TSS200 0.164 1.740E709cg01942646 1 27,240,694 NR0B2 TSS200 0.158 2.138E710cg05778820 1 27,471,782 SLC9A1 Body 0.158 8.219E709cg25105990 1 28,921,512 S_Shelf 0.207 1.109E708

cg11747820 1 29,584,023 PTPRU;PTPRU;PTPRU Body;Body;Body N_Shore 0.175 2.766E708cg08128087 1 33,593,457 S_Shore 0.200 4.044E708cg27292099 1 39,853,529 MACF1;MACF1 Body;Body 0.187 3.704E708cg20966426 1 40,167,317 0.201 9.204E710cg18155101 1 41,345,795 N_Shelf 0.181 1.225E708cg09256082 1 41,449,199 CTPS Body S_Shelf 0.203 9.716E709cg08037719 1 41,962,778 S_Shore 0.175 6.149E708cg09278187 1 42,644,032 FOXJ3 3'UTR 0.192 7.120E710cg09989037 1 44,300,942 ST3GAL3;ST3GAL3;ST3GAL3;ST3GAL3;ST3GAL3;ST3GAL3;ST3GAL3;ST3GAL3;ST3GAL3;ST3GAL3Body;Body;Body;Body;Body;Body;Body;Body;Body;Body 70.183 9.657E708cg12755814 1 44,461,890 CCDC24 3'UTR 0.220 3.392E710cg17329287 1 44,870,688 RNF220 TSS1500 N_Shore 70.195 4.260E709cg08638929 1 46,640,255 TSPAN1 TSS1500 0.214 7.454E708cg26864230 1 47,911,508 S_Shore 70.162 9.394E708cg07209765 1 47,985,223 0.187 5.474E708cg21283167 1 47,986,245 0.172 2.438E709cg26365147 1 48,038,677 0.225 2.684E709cg17076795 1 49,244,849 AGBL4 Body S_Shelf 0.216 2.968E710cg21366602 1 51,887,613 EPS15;EPS15 1stExon;Body 0.204 3.098E711cg02670343 1 51,888,289 EPS15;EPS15 TSS1500;Body 0.216 4.871E711cg10027723 1 51,888,574 EPS15;EPS15 TSS1500;Body 0.198 1.249E711cg00094585 1 53,631,322 0.224 5.372E708cg06645987 1 53,928,411 DMRTB1 Body S_Shelf 0.195 6.223E708cg26932889 1 54,135,470 GLIS1 5'UTR 0.205 1.887E709cg15990451 1 56,025,098 0.264 6.407E710cg26886424 1 56,090,378 0.230 1.425E708cg10181192 1 56,840,643 0.194 2.854E708cg26248114 1 56,901,693 0.189 1.772E709cg16738453 1 57,029,014 PPAP2B;PPAP2B Body;Body 0.198 2.031E708cg00829404 1 61,362,869 0.154 1.982E710cg04486648 1 63,190,136 0.152 2.395E708cg01049068 1 64,504,189 ROR1;ROR1 Body;Body 0.180 1.882E708cg08462879 1 66,458,116 PDE4B;PDE4B;PDE4B Body;TSS1500;Body 0.167 1.124E709

cg03435439 1 66,458,361 PDE4B;PDE4B;PDE4B TSS200;Body;Body 0.260 1.754E710cg26912671 1 66,458,803 PDE4B;PDE4B;PDE4B Body;1stExon;Body 0.333 4.231E708cg12411964 1 66,818,958 PDE4B;PDE4B;PDE4B;PDE4B Body;Body;Body;Body 0.185 3.671E708cg09861436 1 67,515,873 SLC35D1 Body N_Shelf 0.177 7.945E708cg11209521 1 68,209,155 GNG12 5'UTR 0.214 3.448E708cg00320094 1 68,695,183 GPR177;GPR177 Body;Body N_Shore 0.169 5.143E709cg27173965 1 68,841,715 0.185 1.748E708cg16058975 1 80,192,949 0.181 1.929E708cg12743388 1 84,755,291 0.323 3.821E709cg21422605 1 85,313,514 LPAR3 Body 0.218 7.330E709cg06350257 1 87,597,369 LOC339524;LOC339524;LOC339524;LOC339524;LOC339524Body;TSS1500;Body;TSS1500;TSS1500N_Shore 0.262 1.012E708cg10241183 1 88,026,790 0.233 1.442E708cg25140444 1 89,196,864 PKN2 Body 0.246 5.272E709cg10324998 1 92,338,262 TGFBR3 5'UTR 70.169 1.915E709cg22514229 1 94,118,054 BCAR3 Body 0.169 9.153E710cg18220365 1 97,434,409 0.181 8.937E709cg08480307 1 100,547,766 HIAT1 3'UTR 0.233 2.402E710cg08655800 1 109,735,314 KIAA1324 Body 0.153 1.734E708cg19088141 1 113,056,151 WNT2B;WNT2B Body;Body S_Shelf 0.159 5.156E708cg10111629 1 113,067,124 ST7L;ST7L;ST7L 3'UTR;3'UTR;3'UTR 0.213 6.979E710cg13393917 1 114,521,301 OLFML3 TSS1500 0.150 4.197E708cg21931680 1 115,238,457 AMPD1 TSS1500 0.262 1.453E710cg23523368 1 115,238,494 AMPD1 TSS1500 0.229 1.869E711cg15740508 1 115,238,559 AMPD1 TSS1500 0.232 7.648E710cg07037778 1 115,826,414 0.193 7.224E710cg13799671 1 117,079,567 CD58;CD58;CD58 Body;Body;Body S_Shelf 0.208 3.343E708cg12267236 1 117,527,582 PTGFRN Body 0.220 7.204E709cg04282029 1 149,890,655 SV2A TSS1500 0.209 1.973E708cg24262376 1 151,137,274 SCNM1;LYSMD1;LYSMD1 TSS1500;Body;Body 0.171 1.435E708cg12604435 1 153,653,559 NPR1 Body S_Shore 0.151 5.607E708cg11203905 1 156,107,559 LMNA;LMNA;LMNA Body;3'UTR;Body S_Shore 0.166 1.234E708cg00105102 1 156,217,178 PAQR6;PAQR6 5'UTR;5'UTR S_Shore 0.164 6.921E708cg05722371 1 160,247,151 PEX19;PEX19 3'UTR;3'UTR 0.247 3.460E709cg23038349 1 160,765,225 LY9;LY9 TSS1500;TSS1500 0.269 2.402E708cg23050079 1 160,765,349 LY9;LY9 TSS1500;TSS1500 0.226 3.299E710cg10106388 1 160,832,662 CD244;CD244;CD244;CD244;CD244;CD2441stExon;5'UTR;1stExon;5'UTR;5'UTR;1stExon 70.214 2.684E709cg05650171 1 161,089,102 PFDN2;NIT1 TSS1500;Body S_Shore 0.163 6.045E709cg09799585 1 161,956,573 OLFML2B Body S_Shelf 0.179 1.920E709cg13377324 1 162,759,914 HSD17B7 TSS1500 N_Shore 0.160 1.132E708cg09579760 1 163,132,916 RGS5 Body 0.222 5.821E708cg10539928 1 164,693,462 PBX1 Body 0.255 1.380E708cg09751818 1 167,680,554 N_Shelf 0.198 7.087E709cg21940308 1 167,766,195 0.205 2.585E709cg04556393 1 167,849,931 ADCY10;ADCY10 Body;Body 0.174 4.720E710cg21266845 1 168,698,479 DPT TSS200 0.165 5.260E708cg12500707 1 170,115,042 METTL11B TSS200 0.168 4.579E708cg03192897 1 170,115,351 METTL11B 1stExon 0.168 1.239E708cg24376434 1 170,634,859 PRRX1;PRRX1 Body;Body S_Shore 70.229 3.648E709cg00916255 1 170,634,931 PRRX1;PRRX1 Body;Body S_Shore 70.283 7.934E708cg05822335 1 171,179,875 FMO2 3'UTR 0.153 4.041E708cg14973798 1 171,723,758 0.216 6.725E708cg25722073 1 172,351,357 DNM3;DNM3 Body;Body 0.236 8.101E708cg25096142 1 173,572,181 SLC9A11;SLC9A11 1stExon;5'UTR 0.245 9.663E708cg04506114 1 179,322,762 SOAT1 Body 0.236 3.008E708cg17502780 1 182,176,185 0.159 1.962E708cg12136256 1 183,952,796 GLT25D2 Body 0.238 2.549E710cg15204595 1 184,003,184 GLT25D2 Body N_Shelf 0.234 5.206E708cg09013655 1 184,005,063 GLT25D2 Body N_Shore 0.241 8.105E708cg01068808 1 184,007,101 GLT25D2 TSS1500 S_Shore 0.205 5.265E708cg21118367 1 184,460,875 C1orf21 Body 70.201 5.796E708cg11970163 1 184,852,820 FAM129A Body 0.203 8.046E708cg16711983 1 184,858,456 FAM129A Body 0.183 3.884E708cg00968640 1 185,834,094 HMCN1 Body 0.320 7.627E709cg16712103 1 193,150,499 B3GALT2;CDC73 Body;Body 0.167 4.858E708cg04830440 1 199,304,781 0.197 5.219E708cg10539122 1 201,777,275 NAV1;MIR1231;NAV1 Body;TSS1500;Body 0.172 2.525E708cg21139518 1 201,880,363 LMOD1 Body 0.168 3.904E709cg15511928 1 201,895,256 LMOD1 Body 0.173 7.191E709cg06876872 1 202,110,290 ARL8A Body N_Shelf 0.177 9.664E709cg24376793 1 202,545,589 PPP1R12B;PPP1R12B;PPP1R12B;PPP1R12B3'UTR;Body;3'UTR;Body 0.156 1.331E708cg19678564 1 203,115,918 ADORA1;ADORA1 Body;Body 0.221 3.697E709cg17850539 1 203,708,912 ATP2B4;ATP2B4 3'UTR;Body 0.209 8.155E708cg10577713 1 204,401,413 PIK3C2B Body 0.210 6.715E709cg01064725 1 204,461,714 N_Shore 0.181 6.242E709cg06459724 1 205,745,431 RAB7L1;RAB7L1;RAB7L1;RAB7L1 TSS1500;TSS1500;TSS1500;TSS1500 S_Shore 0.199 6.123E709cg00762738 1 205,780,033 SLC41A1 5'UTR N_Shore 0.212 9.035E710cg00920668 1 207,991,122 LOC148696 TSS1500 0.214 3.522E708cg06155620 1 209,527,581 0.166 1.489E709cg06813419 1 211,502,171 TRAF5;TRAF5 5'UTR;5'UTR S_Shore 0.204 6.649E708cg02900760 1 212,261,297 DTL Body 0.245 3.543E708cg24486958 1 212,841,257 70.157 2.957E709cg11179816 1 213,573,219 0.154 2.496E708cg00852051 1 214,006,138 0.168 5.580E708cg18160841 1 215,447,751 0.215 4.388E710cg18533525 1 217,581,184 0.170 8.099E709cg15011026 1 217,604,611 GPATCH2 Body 0.261 3.241E709cg19313660 1 219,606,404 0.198 2.817E710cg24250684 1 219,729,030 0.182 4.511E708cg04250873 1 220,473,634 0.157 9.467E708cg09894814 1 222,217,065 0.159 1.454E709cg22531266 1 222,278,177 0.193 3.358E709cg23808270 1 223,148,963 DISP1 Body 0.233 1.116E709

cg12653626 1 229,359,488 0.179 5.515E708cg16314254 1 230,249,965 GALNT2 Body 0.203 1.716E708cg04836714 1 230,386,762 GALNT2 Body 0.195 4.127E708cg17008160 1 232,315,535 0.164 1.747E708cg10228857 1 234,232,196 SLC35F3 Body 0.207 3.148E709cg26802210 1 234,370,650 SLC35F3 Body S_Shelf 0.265 8.337E708cg25463688 1 235,254,025 0.166 8.244E711cg08454015 1 240,078,452 70.165 3.879E709cg09665406 1 244,262,921 0.160 7.795E709cg14384416 2 193,393 0.152 1.075E708cg24573898 2 203,715 0.195 1.680E708cg16521213 2 277,384 ACP1;ACP1;ACP1 3'UTR;3'UTR;Body 0.250 6.703E709cg07608848 2 1,647,185 PXDN Body 0.336 9.915E711cg15796818 2 1,647,197 PXDN Body 0.319 8.697E710cg14994258 2 1,647,260 PXDN Body 0.289 1.371E708cg27472176 2 1,745,828 PXDN Body N_Shore 0.230 5.028E708cg08569180 2 2,773,427 Island 0.167 2.021E709cg05215481 2 2,773,529 Island 0.174 1.650E709cg19568844 2 2,773,984 S_Shore 0.233 1.198E709cg07948095 2 3,173,279 0.163 6.499E709cg16675485 2 6,055,439 0.177 1.670E708cg25803107 2 6,072,744 LOC150622 TSS200 0.176 6.387E708cg25686172 2 6,072,801 LOC150622 TSS200 0.187 7.057E708cg04747036 2 6,072,981 LOC150622 Body 0.198 5.777E708cg00913787 2 6,376,422 N_Shore 0.168 8.371E710cg09666977 2 6,665,312 0.152 6.539E710cg08398132 2 8,557,381 0.218 3.091E709cg15478401 2 8,809,556 0.207 6.093E708cg19988235 2 9,945,589 0.195 2.342E709cg13851334 2 10,686,975 0.229 2.191E709cg00138926 2 11,118,414 0.184 1.270E710cg18254183 2 18,353,182 0.192 1.264E709cg26701390 2 19,551,944 OSR1 3'UTR Island 0.167 4.139E708cg16752876 2 19,553,237 OSR1 Body Island 0.184 5.412E709cg00954878 2 19,553,950 OSR1 5'UTR N_Shore 0.181 5.927E709cg03071098 2 19,554,237 OSR1 5'UTR N_Shore 0.153 1.520E708cg02680566 2 19,559,792 OSR1 TSS1500 N_Shore 0.258 1.511E708cg00456326 2 19,560,467 N_Shore 0.185 4.886E710cg00830419 2 20,371,971 0.186 2.354E708cg01703736 2 20,649,480 S_Shore 0.220 2.737E708cg07789367 2 20,868,568 GDF7 Body N_Shore 0.204 5.077E708cg05757475 2 21,666,440 0.206 2.343E709cg24703400 2 21,880,071 0.168 4.043E708cg08840913 2 24,139,933 ATAD2B Body 0.172 6.201E708cg00157016 2 24,344,064 PFN4 Body N_Shore 0.234 2.008E709cg02115117 2 24,398,668 C2orf84 Body Island 0.154 7.920E708cg04609635 2 24,398,695 C2orf84 Body S_Shore 0.166 1.709E709cg02315489 2 24,398,859 C2orf84 Body S_Shore 0.212 6.606E708cg07752793 2 34,852,273 0.203 3.777E709cg08105813 2 37,699,716 0.161 1.818E708cg25341268 2 37,734,390 0.156 4.588E709cg10481134 2 38,387,443 C2orf58 Body 0.151 2.773E708cg14120534 2 39,389,290 0.201 8.969E709cg04461334 2 39,660,945 MAP4K3 Body N_Shelf 0.172 3.832E709cg27110007 2 39,668,590 S_Shelf 0.186 3.488E708cg03700279 2 44,576,358 PREPL;PREPL;PREPL;PREPL;PREPL;PREPL;PREPLBody;Body;5'UTR;5'UTR;Body;Body;Body 0.200 5.288E710cg00518941 2 46,361,964 PRKCE Body 0.173 3.733E709cg00409434 2 46,414,317 PRKCE 3'UTR 0.242 2.628E709cg19323703 2 46,498,015 0.172 1.494E708cg18064917 2 47,420,867 0.170 3.010E709cg06842253 2 47,863,922 0.253 6.356E710cg20341504 2 54,900,998 70.253 6.301E708cg06795523 2 58,358,974 VRK2;VRK2;VRK2;VRK2;VRK2;VRK2 Body;Body;Body;Body;Body;Body 0.175 2.126E708cg03064626 2 61,778,147 0.192 2.286E708cg15732840 2 63,274,615 LOC100132215 Body Island 70.182 3.470E708cg19931529 2 64,072,167 UGP2;UGP2 Body;5'UTR S_Shelf 0.185 3.457E708cg17612681 2 66,298,197 0.210 4.784E708cg03819089 2 66,298,217 0.197 9.816E710cg17459215 2 66,298,242 0.195 1.074E708cg12245706 2 71,823,484 DYSF;DYSF;DYSF;DYSF;DYSF;DYSF;DYSF;DYSF;DYSF;DYSF;DYSF;DYSF;DYSF;DYSFBody;Body;Body;Body;Body;Body;Body;Body;Body;Body;Body;Body;Body;Body0.243 4.595E709cg14196395 2 71,823,517 DYSF;DYSF;DYSF;DYSF;DYSF;DYSF;DYSF;DYSF;DYSF;DYSF;DYSF;DYSF;DYSF;DYSFBody;Body;Body;Body;Body;Body;Body;Body;Body;Body;Body;Body;Body;Body0.269 7.561E709cg25445634 2 73,314,239 RAB11FIP5 Body 0.200 9.875E709

cg10553983 2 73,318,514 RAB11FIP5 Body 0.154 2.705E708cg16936561 2 73,338,081 RAB11FIP5 Body N_Shore 0.165 2.045E708cg01355757 2 74,272,773 TET3 TSS1500 0.217 1.530E708cg08940570 2 74,780,617 LOXL3;DOK1 5'UTR;TSS1500 N_Shore 0.159 7.172E709cg12815355 2 75,894,077 C2orf3 Body 0.156 3.359E708cg04067517 2 76,017,724 0.198 3.362E709cg17646721 2 80,197,796 CTNNA2;CTNNA2 Body;Body 0.157 2.706E708cg10142315 2 84,930,277 DNAH6 Body 0.175 1.417E708cg19622777 2 86,341,240 PTCD3 Body 0.247 1.966E708cg02170525 2 87,018,382 CD8A;CD8A;CD8A;CD8A;CD8A;CD8A 5'UTR;1stExon;5'UTR;Body;5'UTR;1stExonS_Shore 70.155 2.320E708cg15600915 2 97,618,624 FAM178B Body 0.187 6.689E709cg11577355 2 100,722,474 AFF3;AFF3 TSS1500;5'UTR S_Shore 0.158 6.130E711cg11428546 2 100,723,110 AFF3;AFF3 TSS1500;5'UTR S_Shelf 0.189 3.280E710cg25628433 2 101,541,328 NPAS2 Body 0.155 9.488E709cg23633210 2 101,600,602 NPAS2 Body 0.206 9.759E710cg04623297 2 102,051,587 RFX8 Body 0.188 9.334E708cg27425459 2 105,697,589 MRPS9 Body 0.166 1.900E708cg26109568 2 105,697,685 MRPS9 Body 0.242 4.439E711

cg12935350 2 105,697,777 MRPS9 Body 0.185 1.240E709cg10808560 2 106,500,430 NCK2;NCK2;NCK2 Body;Body;Body S_Shore 0.167 2.726E708cg21661768 2 106,512,578 S_Shelf 0.163 1.339E708cg04755386 2 109,622,481 0.217 7.898E708cg23986590 2 109,934,728 SH3RF3 Body 0.165 1.322E708cg21408197 2 114,584,240 0.152 1.652E708cg10266681 2 125,183,768 CNTNAP5 Body 0.207 1.108E708cg04946274 2 127,963,067 CYP27C1 5'UTR 0.187 7.066E709cg07054292 2 127,963,330 CYP27C1;CYP27C1 1stExon;5'UTR 0.163 3.150E708cg27614215 2 129,251,945 S_Shore 0.225 6.287E710cg11452043 2 131,814,000 FAM168B Body 0.175 1.295E708cg21078330 2 134,104,516 NCKAP5;NCKAP5 Body;Body 0.198 8.055E709cg01080368 2 135,480,456 S_Shelf 0.202 4.388E709cg23154270 2 137,527,566 S_Shelf 0.249 3.258E708cg17600630 2 144,053,418 ARHGAP15 Body 0.188 1.936E708cg08820401 2 144,501,227 ARHGAP15 Body 0.215 9.110E708cg06228407 2 146,571,856 0.184 6.062E708cg04953238 2 153,196,858 FMNL2 Body S_Shelf 0.188 5.129E709cg06343233 2 153,375,639 FMNL2 Body 0.246 5.948E710cg24579667 2 157,280,411 0.173 7.949E709cg24936299 2 159,672,354 DAPL1 3'UTR 0.204 4.786E708cg11809342 2 160,007,430 TANC1;TANC1 Body;Body 0.159 3.725E708cg15635633 2 161,850,423 0.166 7.969E708cg07617207 2 161,920,006 0.188 2.146E708cg16172329 2 162,907,368 DPP4 Body 0.242 6.292E710cg00324128 2 166,325,614 0.183 4.760E709cg12032648 2 166,676,897 0.203 1.660E708cg02056098 2 167,233,372 SCN9A TSS1500 S_Shore 0.176 7.121E709cg07903472 2 168,846,657 STK39 Body 0.203 2.404E708cg13285387 2 168,863,366 STK39 Body 0.168 2.332E708cg11775828 2 169,100,915 STK39 Body N_Shelf 0.154 9.457E708cg05336056 2 170,142,388 LRP2 Body 0.158 9.714E709cg08471173 2 171,012,543 0.216 2.959E710cg04198323 2 171,828,959 N_Shore 0.199 4.667E708cg21335378 2 173,150,101 70.173 4.200E709cg19153228 2 173,902,435 RAPGEF4;RAPGEF4 Body;Body 0.256 2.175E710cg16721418 2 174,517,573 0.186 6.599E709cg24401656 2 175,450,074 WIPF1;WIPF1 Body;Body 0.181 3.413E708cg06896987 2 177,003,735 N_Shore 70.383 6.867E708cg11248896 2 177,003,747 N_Shore 70.371 1.006E708cg22344631 2 177,012,133 N_Shore 70.164 2.022E709cg17818471 2 177,012,640 Island 70.202 6.196E708cg23402305 2 178,178,939 LOC100130691 Body 0.173 2.634E708cg21251140 2 181,544,642 0.159 4.428E709cg23477967 2 188,419,087 TFPI;TFPI;TFPI;TFPI 1stExon;5'UTR;1stExon;5'UTR 70.176 7.358E708cg15599483 2 190,442,823 SLC40A1 Body N_Shelf 0.212 8.090E708cg11941015 2 191,047,984 C2orf88;C2orf88;C2orf88;C2orf88 5'UTR;5'UTR;5'UTR;5'UTR S_Shelf 0.231 7.673E709cg22885000 2 192,223,280 MYO1B;MYO1B;MYO1B Body;Body;Body 0.232 1.369E708cg06501988 2 196,696,232 DNAH7 Body 0.189 4.150E708cg06226703 2 201,242,945 SPATS2L;SPATS2L;SPATS2L;SPATS2L 5'UTR;5'UTR;5'UTR;5'UTR 0.156 4.131E708cg24306177 2 202,988,297 0.155 7.938E708cg23515702 2 206,673,425 0.238 8.178E709cg26232945 2 208,798,601 PLEKHM3 Body S_Shelf 0.213 2.833E709cg00063369 2 213,811,478 0.157 2.614E709cg23546106 2 216,764,063 70.185 1.012E710cg02177444 2 216,795,947 0.232 1.092E710cg18752854 2 218,809,254 TNS1 TSS1500 0.164 5.434E708cg08120986 2 218,816,280 0.187 8.292E709cg06867089 2 218,867,385 0.157 2.199E710cg08106288 2 220,007,315 NHEJ1 Body 0.255 3.718E708cg10062065 2 220,308,747 SPEG Body N_Shore 0.169 1.819E708cg19581790 2 222,644,621 0.206 6.759E710cg23281972 2 223,610,984 0.290 7.027E708cg09638264 2 228,735,722 WDR69 TSS1500 N_Shore 0.287 1.615E708cg21663666 2 232,220,549 0.205 2.625E709cg22374586 2 232,220,566 0.245 7.794E710cg19485804 2 233,878,714 NGEF TSS1500 0.264 6.796E709cg17032858 2 234,164,131 ATG16L1;ATG16L1 Body;Body S_Shelf 0.324 2.397E708cg08051105 2 234,369,965 DGKD;DGKD Body;Body Island 0.170 9.493E709cg22908000 2 237,489,107 CXCR7 5'UTR 0.195 9.585E709cg22245096 2 238,681,052 LRRFIP1;LRRFIP1 Body;Body 0.247 5.772E710cg03218584 2 239,511,283 0.170 3.678E708cg20706597 2 240,062,121 HDAC4 Body S_Shore 0.194 4.286E709cg17337791 2 240,734,980 N_Shelf 0.152 5.154E708cg05240712 2 241,533,389 CAPN10;CAPN10;CAPN10;CAPN10 Body;Body;Body;Body N_Shelf 0.151 2.310E708cg00829091 2 241,533,694 CAPN10;CAPN10;CAPN10;CAPN10 Body;Body;Body;Body N_Shore 0.170 2.234E708cg08589214 2 241,535,685 CAPN10;CAPN10;CAPN10;CAPN10 Body;Body;Body;Body Island 0.156 3.473E709cg10078335 2 241,535,845 CAPN10;CAPN10;CAPN10;CAPN10 Body;Body;Body;Body Island 0.161 4.636E709cg21464220 2 242,242,798 HDLBP 5'UTR 0.172 7.317E710cg18860854 2 242,293,175 SEPT2;SEPT2;SEPT2;SEPT2 3'UTR;3'UTR;3'UTR;3'UTR N_Shelf 0.182 2.550E708cg10159529 3 3,152,530 IL5RA;IL5RA;IL5RA;IL5RA;IL5RA;IL5RA TSS1500;TSS1500;TSS1500;TSS1500;TSS1500;TSS1500 0.158 7.690E710cg05648614 3 5,180,520 ARL8B Body 0.160 2.259E708cg13231680 3 7,693,146 GRM7;GRM7 Body;Body 0.196 2.763E708cg24612498 3 8,572,798 LMCD1 Body 0.183 1.951E708cg04695796 3 9,809,922 CAMK1 5'UTR N_Shore 0.154 1.577E708cg16204414 3 10,325,494 C3orf42 TSS1500 0.155 9.293E709cg20235117 3 10,368,030 ATP2B2;ATP2B2 3'UTR;3'UTR N_Shelf 0.169 1.045E708cg02228403 3 11,522,965 ATG7;ATG7;ATG7 Body;Body;Body 0.191 9.062E710cg04585669 3 11,599,640 VGLL4;VGLL4;VGLL4;VGLL4 3'UTR;3'UTR;3'UTR;3'UTR 0.179 5.830E709cg08815359 3 11,606,853 VGLL4;VGLL4;VGLL4;VGLL4 Body;Body;Body;Body N_Shelf 0.169 5.092E708cg10586672 3 14,514,657 SLC6A6;SLC6A6 Body;Body 0.185 6.800E708cg01633093 3 16,216,606 GALNTL2;GALNTL2 5'UTR;1stExon 0.160 1.306E708

cg05463136 3 16,286,371 0.221 2.529E709cg07654588 3 17,782,211 TBC1D5;TBC1D5;TBC1D5 1stExon;5'UTR;5'UTR N_Shore 0.154 9.645E708cg26296894 3 20,183,665 KAT2B Body 0.168 3.769E708cg12933903 3 20,223,923 SGOL1;SGOL1;SGOL1;SGOL1;SGOL1;SGOL1Body;Body;Body;Body;Body;Body N_Shelf 0.312 2.119E709cg10288467 3 20,371,290 0.240 3.850E709cg17547577 3 21,265,890 0.169 4.816E708cg27569887 3 30,045,896 RBMS3;RBMS3 3'UTR;3'UTR 0.207 7.592E709cg03630790 3 30,702,018 TGFBR2;TGFBR2 Body;Body 0.228 3.860E709cg05074709 3 30,733,753 TGFBR2;TGFBR2 3'UTR;3'UTR 0.225 9.715E709cg04370634 3 31,721,446 OSBPL10 Body 0.218 3.922E709cg11858213 3 33,173,098 CRTAP Body 0.161 4.601E709cg21833841 3 36,868,879 TRANK1 3'UTR 0.171 7.593E711cg11014921 3 36,974,725 TRANK1 Body 0.153 8.718E708cg12999063 3 37,225,266 0.289 3.604E710cg14928452 3 37,814,797 ITGA9 Body 0.158 1.654E711cg16566353 3 37,860,954 ITGA9 3'UTR 0.246 1.720E709cg13063313 3 38,110,999 DLEC1;DLEC1 Body;Body 0.179 3.414E708cg02094042 3 38,223,776 OXSR1 Body 0.163 1.974E709cg01486558 3 42,132,870 TRAK1;TRAK1 1stExon;5'UTR 0.187 5.197E708cg09654300 3 42,132,991 TRAK1 1stExon 0.222 2.519E708cg20675173 3 43,795,541 0.202 5.140E710cg20505728 3 43,800,538 0.262 5.969E708cg19850333 3 46,448,579 CCRL2;CCRL2 TSS1500;TSS200 70.157 6.189E708cg10952220 3 46,448,671 CCRL2;CCRL2 TSS1500;TSS200 70.166 3.979E708cg14754581 3 46,448,753 CCRL2;CCRL2;CCRL2 TSS1500;5'UTR;1stExon 70.205 1.751E708cg12579212 3 46,448,868 CCRL2;CCRL2;CCRL2 5'UTR;1stExon;TSS200 70.236 3.549E708cg03477080 3 46,448,920 CCRL2;CCRL2;CCRL2 5'UTR;1stExon;TSS200 70.188 8.854E708cg03676298 3 48,078,103 MAP4;MAP4;MAP4 5'UTR;5'UTR;5'UTR 0.237 2.015E710cg01165661 3 49,157,146 USP19 5'UTR N_Shore 0.183 7.482E708cg00447769 3 49,313,334 C3orf62 Body N_Shore 0.151 2.340E708cg11112833 3 54,913,073 CACNA2D3 Body 0.184 1.668E708cg02955114 3 56,505,929 S_Shelf 0.250 3.410E708cg02491003 3 57,581,393 ARF4 Body N_Shore 0.166 7.060E709cg01361263 3 58,051,763 FLNB;FLNB;FLNB;FLNB Body;Body;Body;Body 0.155 8.989E708cg10763247 3 61,066,614 FHIT;FHIT 5'UTR;5'UTR 0.157 4.429E708cg15253604 3 62,468,682 CADPS;CADPS;CADPS Body;Body;Body 0.214 8.156E709cg03625918 3 62,468,713 CADPS;CADPS;CADPS Body;Body;Body 0.254 8.539E708cg11273702 3 66,935,847 0.161 3.424E708cg13011961 3 67,291,183 0.223 3.061E709cg00970757 3 71,167,804 FOXP1 Body 0.205 1.776E708cg05098381 3 71,301,786 FOXP1;FOXP1 5'UTR;5'UTR 0.163 5.731E710cg05514531 3 81,791,282 GBE1 Body 0.180 2.682E708cg00338631 3 93,677,738 PROS1 Body 0.159 4.039E709cg03656137 3 99,579,802 C3orf26;FILIP1L;MIR548G;FILIP1L;FILIP1LBody;Body;Body;5'UTR;Body 0.208 1.171E708cg24828422 3 99,646,755 C3orf26;FILIP1L;MIR548G;FILIP1L Body;Body;Body;Body 0.215 9.078E709cg04016922 3 99,691,269 C3orf26;FILIP1L;MIR548G;FILIP1L Body;5'UTR;Body;5'UTR 0.257 9.833E709cg27384355 3 99,844,353 C3orf26;C3orf26 Body;Body 0.172 3.174E708cg19852058 3 105,293,613 ALCAM 3'UTR 0.216 9.908E710cg18062333 3 110,446,221 0.155 6.740E708cg05655806 3 111,260,756 CD96;CD96 TSS200;TSS200 0.203 3.057E709cg08365738 3 112,324,301 CCDC80;CCDC80 Body;Body 70.168 4.224E708cg20770409 3 112,463,996 0.161 3.627E709cg19892944 3 113,217,290 CCDC52 Body 0.203 1.065E709cg27504195 3 113,342,400 SIDT1 Body 0.180 8.353E709cg22253393 3 115,194,543 0.158 6.818E710cg19868730 3 119,380,012 POPDC2 TSS1500 0.164 2.863E708cg12146073 3 121,196,810 POLQ Body 0.163 4.502E709cg09851981 3 121,453,622 GOLGB1 5'UTR 0.203 2.780E709cg10523671 3 121,612,956 SLC15A2;SLC15A2 TSS1500;TSS1500 0.178 4.810E709cg25364913 3 122,610,021 LOC100129550 Body 0.183 4.605E708cg17633431 3 122,712,138 SEMA5B 5'UTR 0.158 1.833E708cg11928064 3 124,537,810 ITGB5 Body 0.231 2.010E708cg01311222 3 124,776,153 HEG1 TSS1500 S_Shore 0.194 4.925E709cg11591485 3 124,839,640 SLC12A8 Body 0.155 7.876E708cg11835020 3 125,924,910 0.195 7.926E709cg00234321 3 126,061,332 N_Shore 0.184 8.414E708cg08012252 3 126,465,994 CHCHD6 Body 0.200 1.467E709cg18073874 3 127,982,562 EEFSEC Body 0.211 1.893E710cg08524190 3 128,825,270 RAB43 Body 0.178 1.139E711cg14668981 3 133,112,774 TMEM108;TMEM108 Body;Body 0.161 4.312E708cg15699627 3 139,649,460 N_Shelf 0.217 1.554E708cg12657361 3 141,161,911 ZBTB38 Body 0.194 6.618E708cg06145736 3 143,559,620 SLC9A9 Body 0.159 1.866E708cg24969222 3 143,861,209 0.158 1.217E708cg10729196 3 149,797,095 0.159 5.122E709cg04779597 3 150,345,472 SELT 3'UTR 0.195 5.418E708cg16537483 3 152,019,539 MBNL1;MBNL1;MBNL1;MBNL1;MBNL1;MBNL1;MBNL1Body;Body;Body;Body;Body;Body;Body 0.179 4.572E708cg12611897 3 155,349,216 PLCH1;PLCH1;PLCH1 Body;Body;5'UTR 0.205 1.739E709cg18794809 3 156,480,627 0.177 8.555E709cg01384290 3 168,870,287 MECOM Body S_Shelf 0.241 8.858E708cg09616857 3 169,122,917 MECOM Body 0.236 6.481E709cg01423389 3 170,746,586 S_Shore 0.155 2.578E709cg00000109 3 171,916,037 FNDC3B;FNDC3B Body;Body 0.191 4.087E708cg08812689 3 172,042,767 FNDC3B;FNDC3B Body;Body 0.162 2.147E708cg04784618 3 174,988,389 NAALADL2 Body 0.177 1.095E708cg08166991 3 179,037,970 N_Shelf 0.240 4.126E709cg16340446 3 179,318,612 MRPL47;MRPL47 5'UTR;Body N_Shelf 0.308 4.396E709cg12222244 3 181,633,701 0.179 6.266E708cg06013395 3 184,280,712 EPHB3 Body Island 0.160 4.556E708cg01037523 3 187,078,716 0.171 3.675E708cg21463380 3 187,389,127 SST TSS1500 S_Shore 0.173 5.337E709cg27338202 3 187,481,967 0.212 1.313E710

cg04952622 3 188,067,331 LPP;LPP;LPP 5'UTR;5'UTR;5'UTR 0.227 9.129E709cg02521428 3 188,083,758 LPP;LPP;LPP 5'UTR;5'UTR;5'UTR 0.170 8.113E708cg01361361 3 188,618,380 0.199 3.021E710cg27225068 3 188,623,991 0.206 2.056E709cg24286174 3 188,697,399 0.286 4.780E709cg23238530 3 189,834,383 LEPREL1;LEPREL1 5'UTR;Body N_Shelf 0.177 6.704E708cg19066520 3 191,046,547 CCDC50;UTS2D;CCDC50 TSS1500;5'UTR;TSS1500 N_Shore 0.269 9.516E709cg04571652 3 192,959,762 MGC2889;HRASLS Body;5'UTR S_Shore 0.242 9.506E710cg16241473 3 193,361,843 OPA1;OPA1;OPA1;OPA1;OPA1;OPA1;OPA1;OPA1Body;Body;Body;Body;Body;Body;Body;Body 0.170 3.909E708cg03575245 3 194,785,559 N_Shore 0.164 8.282E709cg07404527 3 197,159,730 0.156 2.502E708cg21320793 4 646,853 PDE6B;PDE6B;PDE6B TSS200;Body;Body N_Shore 0.203 2.515E709cg14378348 4 1,029,410 Island 0.162 9.778E710cg07928191 4 1,205,359 CTBP1;CTBP1 3'UTR;3'UTR N_Shore 0.157 6.248E709cg17118391 4 1,583,898 S_Shore 0.162 3.447E708cg04073934 4 3,372,272 RGS12;RGS12;RGS12 Body;Body;Body N_Shelf 0.184 9.476E708cg05498905 4 6,955,698 TBC1D14;TBC1D14 Body;Body 0.185 3.939E708cg04497889 4 7,046,407 TADA2B Body S_Shore 0.162 1.115E708cg13318771 4 7,657,359 SORCS2 Body 0.169 5.155E708cg24250820 4 7,887,609 AFAP1;AFAP1 5'UTR;5'UTR 0.220 2.583E708cg20277282 4 8,230,053 SH3TC1 Body 0.187 4.967E708cg15984712 4 8,346,218 N_Shore 0.221 8.870E709cg00895231 4 8,346,274 N_Shore 0.201 1.617E709cg25599924 4 8,396,056 ACOX3;ACOX3 Body;Body 0.156 6.604E708cg06005199 4 8,474,290 C4orf23 Body 0.154 5.006E709cg24182798 4 10,065,218 0.155 2.467E709cg23069057 4 14,867,316 S_Shelf 0.242 8.014E709cg06097727 4 15,376,119 C1QTNF7;C1QTNF7 Body;TSS200 0.201 8.644E710cg12526473 4 19,962,859 0.188 1.093E709cg12925881 4 26,050,407 0.158 1.480E709cg19290091 4 27,321,334 0.173 5.738E708cg08343347 4 36,076,000 ARAP2 Body 0.198 4.328E708cg03786225 4 40,651,366 0.162 5.449E708cg25639218 4 53,718,933 0.193 2.616E709cg04231042 4 54,729,555 0.172 2.043E709cg25064395 4 55,143,557 PDGFRA Body 70.170 5.165E709cg05123646 4 55,376,733 0.155 8.756E708cg21145416 4 55,795,664 0.153 5.449E709cg20002207 4 57,957,811 IGFBP7 Body 0.221 4.669E708cg09415518 4 69,093,675 TMPRSS11B Body 0.247 3.316E708cg04558553 4 69,960,869 UGT2B7 TSS1500 0.181 3.244E708cg25583503 4 69,962,676 UGT2B7 1stExon 0.163 7.310E709cg15044252 4 73,020,263 0.172 3.167E709cg02387745 4 74,317,457 AFP Body 0.189 3.077E709cg25291311 4 75,565,771 0.202 8.855E708cg00223792 4 75,618,840 0.214 2.862E708cg21619340 4 77,531,254 SHROOM3 Body 0.259 8.775E709cg27466235 4 77,625,095 SHROOM3 Body 0.198 4.084E708cg15871969 4 77,665,102 SHROOM3 Body S_Shelf 0.210 1.522E708cg10104674 4 79,052,724 FRAS1;FRAS1 Body;Body 0.153 6.938E709cg01307684 4 80,886,143 ANTXR2 Body Island 0.229 3.326E709cg11539055 4 80,886,264 ANTXR2 Body S_Shore 0.277 3.772E709cg01174264 4 80,992,999 ANTXR2;ANTXR2 Body;Body N_Shore 70.190 2.873E708cg03441770 4 81,128,845 S_Shore 0.198 1.279E709cg26308042 4 87,738,323 0.239 1.635E708cg09565526 4 87,812,668 C4orf36 Body N_Shore 0.164 3.216E708cg05350879 4 88,451,223 SPARCL1;SPARCL1 TSS1500;TSS1500 0.156 4.460E709cg14334389 4 88,451,346 SPARCL1;SPARCL1 TSS1500;TSS1500 0.173 3.365E709cg26215428 4 88,928,251 PKD2 TSS1500 N_Shore 0.168 3.277E708cg23246886 4 99,552,952 TSPAN5 Body 0.176 5.562E708cg15508749 4 109,115,092 0.208 1.197E709cg08057869 4 109,681,383 AGXT2L1;AGXT2L1;AGXT2L1;AGXT2L1;AGXT2L1Body;Body;Body;Body;Body N_Shelf 0.201 8.184E709cg16701124 4 115,406,970 0.183 2.733E708cg14204430 4 116,035,217 NDST4 TSS200 0.170 1.284E709cg00543944 4 123,524,574 0.163 5.614E708cg10583651 4 123,538,969 IL21 Body 0.192 8.923E710cg19576738 4 123,751,635 FGF2 Body S_Shelf 0.223 1.753E709cg20926679 4 126,188,582 0.155 1.247E708cg11976164 4 126,426,949 MIR2054 TSS1500 0.200 1.572E709cg25214552 4 127,891,291 0.182 1.145E708cg19839601 4 134,459,203 0.159 1.755E709cg21634993 4 140,619,779 MGST2 Body Island 0.153 1.753E708cg01314488 4 143,286,770 INPP4B;INPP4B Body;Body 0.166 6.148E708cg10773526 4 143,327,279 INPP4B;INPP4B Body;Body 0.190 7.320E711cg25230117 4 146,104,495 S_Shelf 0.263 4.425E709cg26807233 4 146,736,991 ZNF827 Body 0.211 3.226E709cg27131703 4 147,971,312 0.190 4.968E708cg26811385 4 150,832,003 70.151 3.076E709cg08028974 4 151,004,321 DCLK2;DCLK2 Body;Body S_Shelf 0.200 2.782E708

cg11239720 4 152,967,415 0.154 4.624E709cg03875996 4 159,442,782 RXFP1 TSS1500 0.264 2.098E708cg00168032 4 160,018,054 0.226 2.906E710cg24466738 4 165,172,491 41334 5'UTR 0.234 4.675E709cg09030852 4 170,629,768 CLCN3;CLCN3 Body;Body 0.236 2.562E709cg02307239 4 174,421,558 Island 70.158 5.389E708cg04840702 4 174,422,626 S_Shore 70.169 1.688E710cg09846177 4 174,437,333 N_Shore 70.164 3.589E709cg12541454 4 174,437,915 Island 70.166 6.689E708cg06609094 4 175,132,842 N_Shelf 70.164 8.384E709cg00918522 4 175,132,871 N_Shelf 70.188 2.566E709cg07177380 4 175,133,151 N_Shelf 70.207 5.181E708

cg09814128 4 178,243,783 NEIL3 Body 0.196 2.878E708cg25771451 4 180,037,240 0.208 6.946E709cg14232128 4 183,207,543 0.152 6.853E708cg12836958 4 186,132,412 SNX25 5'UTR S_Shore 0.243 8.838E708cg11426170 4 186,961,160 0.216 1.853E708cg01394884 4 186,961,192 0.241 6.363E708cg19091930 5 191,127 LRRC14B TSS1500 N_Shore 0.220 1.248E708cg18867781 5 978,293 0.238 2.135E708cg16360831 5 978,322 0.257 1.617E708cg06437430 5 1,033,714 NKD2 Body 0.176 7.568E708cg26943056 5 2,169,815 0.242 1.205E708cg18820060 5 3,536,525 S_Shore 0.215 3.231E709cg17963461 5 3,844,117 0.247 6.871E708cg09083359 5 3,854,537 Island 0.200 1.093E709cg01890858 5 3,854,704 Island 0.163 1.237E708cg18644703 5 5,887,068 Island 70.155 3.400E708cg10898182 5 5,979,803 0.276 6.067E709cg22057240 5 6,755,843 POLS 3'UTR S_Shore 0.235 7.052E708cg00855685 5 9,543,363 SEMA5A 5'UTR N_Shore 0.158 2.626E708cg13276570 5 10,567,643 ANKRD33B Body S_Shore 0.239 8.136E709cg01608001 5 15,026,851 0.166 2.314E709cg12608692 5 16,742,020 MYO10 Body 0.180 1.107E709cg14689338 5 16,742,054 MYO10 Body 0.159 6.837E708cg16072777 5 17,119,012 70.162 9.893E710cg03880611 5 31,889,373 PDZD2 Body 0.171 1.693E710cg18410110 5 31,963,583 PDZD2 Body 0.184 8.661E708cg03551963 5 39,502,320 70.154 3.323E708cg06597095 5 43,480,361 C5orf28 5'UTR N_Shelf 0.183 9.149E709cg07737131 5 52,319,150 ITGA2 Body 0.193 8.416E709cg02437766 5 53,483,018 ARL15 Body 0.278 4.262E709cg20673840 5 54,281,362 ESM1;ESM1;ESM1;ESM1 1stExon;5'UTR;5'UTR;1stExon 0.159 5.209E709cg02402882 5 56,620,429 0.205 7.284E709cg11197630 5 56,712,591 0.165 7.890E709cg12942552 5 57,749,839 PLK2 3'UTR 0.189 2.732E708cg13983903 5 57,751,418 PLK2 Body N_Shelf 0.261 9.274E710cg02077216 5 57,753,951 PLK2 Body N_Shore 0.220 2.105E708cg05141014 5 59,784,203 PART1;PART1;PDE4D;PART1 Body;Body;TSS1500;Body 0.344 8.307E709cg19602446 5 60,595,854 0.266 3.399E710cg10932486 5 61,028,265 0.159 5.490E709cg09656152 5 61,032,532 0.220 4.426E712cg14787704 5 65,449,380 SFRS12;SFRS12 5'UTR;Body 0.172 3.917E710cg12313341 5 65,771,446 0.155 8.576E708cg22462657 5 68,326,727 0.153 1.974E709cg19616844 5 71,103,650 0.173 6.190E709cg19516619 5 71,126,255 0.199 3.453E708cg24661274 5 71,418,531 MAP1B Body 0.230 2.805E708cg02073775 5 71,478,626 MAP1B Body 0.253 2.096E708cg22685009 5 71,597,700 MRPS27 Body 0.164 4.974E708cg07476923 5 72,528,766 N_Shore 70.158 2.947E708cg11796442 5 72,593,919 N_Shore 70.163 1.568E709cg21198550 5 72,596,701 S_Shore 70.266 1.939E708cg21510348 5 72,596,752 S_Shore 70.177 6.959E709cg08230177 5 72,596,822 S_Shore 70.242 2.977E708cg01937780 5 72,596,939 S_Shore 70.175 4.590E709cg09553242 5 72,597,015 N_Shore 70.189 6.641E709cg18595065 5 72,597,126 N_Shore 70.182 5.534E709cg09835740 5 72,597,231 N_Shore 70.168 1.902E708cg16667631 5 72,597,316 N_Shore 70.170 2.754E708cg25113089 5 72,598,192 N_Shore 70.152 5.450E708cg17573301 5 72,732,265 N_Shore 70.155 1.484E708cg21806100 5 75,794,475 IQGAP2 Body 0.228 1.231E710cg11062417 5 76,578,232 PDE8B;PDE8B;PDE8B;PDE8B;PDE8B Body;Body;Body;Body;Body 0.152 1.279E708cg09645993 5 77,289,836 0.204 4.213E708cg21525176 5 77,906,752 LHFPL2 5'UTR 0.175 9.207E710cg00400992 5 77,923,936 LHFPL2 5'UTR 0.211 5.133E708cg11577898 5 78,094,446 ARSB Body 0.240 1.049E708cg15687395 5 79,379,309 0.163 2.911E708cg17053638 5 82,159,251 0.172 6.718E708cg15526939 5 82,805,379 VCAN;VCAN;VCAN;VCAN Body;Body;Body;Body 0.175 2.509E709cg08891382 5 82,848,792 VCAN;VCAN;VCAN;VCAN Body;Body;Body;Body 0.206 1.007E708cg13322063 5 83,215,335 70.173 6.575E708cg24708882 5 90,369,235 GPR98;GPR98 Body;Body 0.165 3.047E708cg06987348 5 91,715,141 0.189 5.767E708cg08698198 5 92,684,137 0.271 1.650E708cg08224682 5 92,684,164 0.311 4.881E709cg01124922 5 92,684,412 0.163 4.623E708cg01948367 5 93,327,134 FAM172A;FAM172A;FAM172A;FAM172ABody;Body;Body;Body 0.227 6.203E710cg15016062 5 93,576,432 C5orf36 Body 0.249 4.042E708cg12434362 5 95,419,503 70.192 9.652E709cg25539505 5 95,634,103 0.223 1.774E709cg06803420 5 97,971,808 0.228 1.919E708cg01885839 5 111,017,556 0.179 1.540E708cg13292202 5 112,771,367 TSSK1B;MCC TSS1500;Body 0.172 1.836E708cg18520851 5 115,149,189 CDO1 Body N_Shelf 0.327 3.909E710cg04676799 5 115,152,938 CDO1 TSS1500 S_Shore 0.255 1.843E709cg01419670 5 115,696,151 N_Shore 0.160 1.104E708cg23507211 5 115,800,190 SEMA6A Body 0.234 2.485E710cg11560600 5 121,462,562 0.162 1.039E708cg14469693 5 122,518,006 PRDM6 Body 0.155 3.836E708cg19835796 5 123,637,793 0.231 3.242E709cg15380511 5 124,835,828 0.261 9.285E710cg19804027 5 126,988,647 CTXN3;CTXN3 5'UTR;TSS200 0.157 1.078E708

cg13588355 5 126,998,388 0.155 7.655E709cg06675144 5 127,552,620 0.176 4.147E709cg04093645 5 127,872,037 FBN2 Body Island 0.216 1.844E709cg15358549 5 127,872,074 FBN2 Body Island 0.220 1.407E708cg26802026 5 127,872,329 FBN2 Body N_Shore 0.235 1.765E708cg04216073 5 127,878,868 S_Shelf 0.209 6.785E708cg26983445 5 128,085,777 0.230 1.031E710cg20704330 5 131,411,549 CSF2 3'UTR 0.214 9.367E710cg23233650 5 131,835,756 S_Shelf 0.188 2.528E709cg13904481 5 132,118,820 0.275 7.210E709cg11397957 5 132,209,201 LEAP2 TSS200 0.219 1.695E709cg00530568 5 135,587,383 TRPC7;TRPC7;TRPC7 Body;Body;Body 0.219 3.118E708cg19583819 5 139,283,051 NRG2;NRG2;NRG2;NRG2 Body;Body;Body;Body N_Shore 70.155 3.853E708cg17878320 5 142,922,506 0.150 6.211E708cg24193140 5 143,581,779 KCTD16 5'UTR N_Shelf 0.181 1.897E709cg11940973 5 145,939,975 0.158 2.464E708cg12807764 5 146,864,669 0.203 3.232E708cg27308445 5 149,699,675 0.271 7.949E709cg27039501 5 150,029,215 SYNPO;SYNPO;SYNPO;SYNPO Body;Body;Body;Body Island 0.239 4.285E708cg18781383 5 150,089,452 DCTN4;DCTN4;DCTN4 3'UTR;3'UTR;3'UTR 0.211 1.071E708cg10908447 5 153,714,203 GALNT10 Body 0.161 4.944E708cg05169312 5 154,316,775 GEMIN5 Body N_Shore 0.163 1.695E709cg03632357 5 159,504,903 PWWP2A 3'UTR 0.228 7.913E708cg24801535 5 159,800,673 S_Shelf 0.167 1.411E708cg12910830 5 162,929,657 MAT2B TSS1500 N_Shelf 0.180 2.220E709cg21514529 5 168,885,285 0.194 3.056E709cg11661512 5 170,864,692 FGF18 Body 0.173 3.372E708cg25408617 5 172,093,513 NEURL1B Body N_Shelf 0.158 3.539E709cg01691332 5 172,112,831 NEURL1B Body N_Shore 0.157 8.386E708cg08780218 5 172,194,729 N_Shelf 0.175 9.789E709cg26552361 5 172,293,806 ERGIC1 Body 0.284 5.920E710cg15101394 5 172,296,781 ERGIC1 Body 0.191 2.757E708cg11412418 5 172,658,730 N_Shore 70.157 4.074E708cg15618908 5 173,141,761 70.156 1.158E708cg14345676 5 175,109,098 HRH2;HRH2;HRH2 5'UTR;5'UTR;1stExon 0.213 3.317E708cg00238818 5 176,880,261 PRR7 5'UTR N_Shore 0.168 4.333E710cg03032595 5 176,918,190 PDLIM7;PDLIM7;PDLIM7 Body;Body;Body N_Shore 0.191 5.830E708cg27087553 6 1,180,553 0.204 1.550E708cg04130549 6 1,497,870 0.190 2.277E709cg23381884 6 1,597,525 N_Shore 0.241 3.233E708cg08812108 6 2,515,318 0.235 8.805E708cg01189926 6 2,734,480 MYLK4 Body 0.189 3.935E708cg13332807 6 3,869,142 0.212 4.426E708cg18255813 6 7,195,966 RREB1;RREB1;RREB1;RREB1 Body;Body;Body;Body 0.151 8.859E708cg13609089 6 10,610,691 GCNT2;GCNT2;GCNT2 Body;Body;Body 0.209 7.449E710cg01111006 6 11,161,658 0.230 2.023E709cg00525496 6 11,203,784 NEDD9;NEDD9;NEDD9 Body;Body;Body 0.224 6.763E708cg09844094 6 12,586,063 0.211 2.145E709cg10383424 6 12,586,134 0.223 4.673E709cg16465027 6 12,595,019 70.164 9.347E710cg15542608 6 12,827,379 PHACTR1 Body 0.207 5.873E710cg09148630 6 14,492,164 0.230 5.640E709cg19945263 6 14,706,041 0.226 1.120E712cg06755262 6 14,824,437 0.181 2.185E709cg19566879 6 16,334,128 ATXN1;ATXN1 5'UTR;5'UTR 0.205 1.806E708cg19516754 6 16,965,070 0.174 3.493E709cg18747742 6 19,180,751 0.174 4.604E709cg07905141 6 21,200,368 CDKAL1 Body 0.168 1.947E710cg04785902 6 22,878,214 0.204 4.177E708cg24036830 6 28,129,096 ZNF389 TSS1500 0.216 3.649E708cg13036593 6 32,026,299 TNXB Body 0.214 8.711E709cg14713231 6 32,026,302 TNXB Body 0.185 5.053E708cg06365270 6 32,026,350 TNXB Body 0.171 2.524E708cg21951797 6 32,026,605 TNXB Body 0.243 2.432E710cg25596754 6 32,026,610 TNXB Body 0.225 9.618E710cg19071976 6 32,026,656 TNXB Body 0.159 2.852E709cg16225663 6 32,026,797 TNXB Body 0.182 1.122E709cg14669361 6 32,038,747 TNXB Body 0.210 4.239E709cg08660959 6 32,044,163 TNXB Body N_Shelf 0.178 3.987E708cg02133510 6 32,044,959 TNXB Body N_Shore 0.180 9.266E708cg11608893 6 32,059,542 TNXB Body N_Shelf 0.217 3.904E710cg15773251 6 32,078,602 TNXB TSS1500 0.151 3.508E708cg08801479 6 32,165,200 NOTCH4 Body S_Shore 0.175 4.155E708cg15854333 6 33,171,765 HSD17B8;SLC39A7;SLC39A7 TSS1500;3'UTR;3'UTR N_Shore 0.186 2.499E710cg08260450 6 34,993,987 ANKS1A Body 0.223 8.719E708cg11478024 6 35,004,780 ANKS1A Body 0.227 2.822E709cg18595347 6 35,028,490 ANKS1A Body 0.194 8.485E708cg13719443 6 35,700,382 LOC285847 Body S_Shore 70.150 1.142E708cg18891604 6 36,319,055 0.175 4.633E709cg12107072 6 36,826,690 PPIL1 Body 0.170 3.654E708cg00408678 6 36,897,641 0.157 4.358E709cg26891237 6 36,966,223 0.214 1.969E708cg20190922 6 39,769,426 DAAM2 5'UTR 0.154 8.517E709cg13983640 6 41,010,223 TSPO2;TSPO2 TSS1500;TSS200 0.223 1.277E709cg22682201 6 41,020,847 APOBEC2 TSS200 0.208 1.153E708cg17548735 6 41,020,969 APOBEC2;APOBEC2 5'UTR;1stExon 0.169 3.748E710cg20893203 6 41,499,799 70.180 1.633E708cg25289457 6 42,832,508 KIAA0240 Body 0.230 2.192E710cg14414911 6 43,964,296 0.203 7.783E708cg20242070 6 44,510,570 0.237 3.856E709cg04110902 6 45,500,999 RUNX2;RUNX2;RUNX2 Body;Body;Body 0.161 2.437E708cg12019475 6 45,700,739 0.194 3.054E708

cg08811259 6 56,878,665 BEND6 Body 0.201 2.935E709cg04086834 6 71,377,064 SMAP1;SMAP1 TSS1500;TSS1500 N_Shore 0.207 2.708E709cg00929496 6 72,060,594 0.185 1.076E708cg27218993 6 73,263,351 0.199 5.569E709cg02752014 6 76,045,920 FILIP1 Body 0.154 7.459E708cg02586023 6 76,198,240 FILIP1 5'UTR 0.185 2.455E708cg10151799 6 82,271,548 0.187 2.991E709cg13706058 6 85,824,168 0.238 2.607E709cg11452329 6 85,824,216 0.274 3.022E710cg25830548 6 87,041,914 0.206 2.801E708cg13151707 6 90,117,722 RRAGD Body N_Shelf 0.219 4.491E709cg03035849 6 91,003,200 BACH2;BACH2 5'UTR;5'UTR N_Shore 0.222 5.327E708cg12860156 6 98,744,658 0.217 5.520E710cg25295329 6 106,348,603 70.159 7.447E708cg24824472 6 112,111,043 FYN 5'UTR 0.227 3.945E708cg12636607 6 112,154,581 FYN 5'UTR 0.181 4.029E708cg00953399 6 116,867,006 FAM26D;BET3L 5'UTR;TSS1500 0.157 3.963E709cg13520736 6 125,543,048 TPD52L1;TPD52L1;TPD52L1;TPD52L1 Body;Body;Body;Body 0.228 3.918E710cg13919358 6 125,573,188 TPD52L1;TPD52L1;TPD52L1;TPD52L1 Body;Body;Body;Body 0.191 1.159E709cg10462643 6 127,296,973 0.302 1.169E708cg05798147 6 127,781,063 C6orf174;KIAA0408 3'UTR;TSS1500 0.176 6.987E709cg07308751 6 131,287,984 EPB41L2;EPB41L2;EPB41L2 5'UTR;5'UTR;5'UTR 0.244 5.671E709cg25461865 6 131,958,550 ENPP3 1stExon 0.157 1.713E708cg18796704 6 132,216,033 ENPP1 3'UTR 0.225 1.535E708cg14553824 6 137,495,383 IL22RA2;IL22RA2;IL22RA2 TSS1500;TSS1500;TSS1500 0.165 6.128E708cg21730858 6 138,806,320 NHSL1;NHSL1 Body;Body 0.212 1.024E709cg09820180 6 140,168,822 0.178 7.901E709cg00974578 6 143,916,485 0.225 1.178E708cg08482167 6 144,066,847 PHACTR2;PHACTR2;PHACTR2;PHACTR2Body;Body;Body;Body 0.228 7.916E708cg19852921 6 144,074,925 PHACTR2;PHACTR2;PHACTR2;PHACTR2Body;Body;Body;Body 0.249 4.732E709cg01659632 6 144,262,297 PLAGL1;PLAGL1;PLAGL1;PLAGL1;PLAGL1;PLAGL1;PLAGL1;PLAGL13'UTR;3'UTR;3'UTR;3'UTR;3'UTR;3'UTR;3'UTR;3'UTR 0.161 2.206E709cg19517402 6 145,010,923 UTRN Body 0.335 1.130E708cg02274934 6 145,392,278 0.160 1.171E708cg21911930 6 146,009,877 EPM2A;EPM2A Body;Body 0.171 8.841E708cg12047363 6 147,311,573 0.245 4.252E710cg24928900 6 147,705,971 STXBP5;STXBP5 3'UTR;3'UTR 0.188 8.620E708cg12668216 6 148,615,459 0.207 1.054E709cg20162923 6 149,042,321 0.195 1.045E708cg09524613 6 149,097,976 UST Body 0.215 2.823E709cg01163931 6 149,305,804 UST Body 0.168 2.804E708cg14608074 6 150,922,513 PLEKHG1 5'UTR S_Shore 0.156 5.099E708cg00994250 6 151,087,821 PLEKHG1 Body 0.188 5.516E709cg13777287 6 154,830,168 CNKSR3 Body N_Shore 0.206 8.224E709cg11614093 6 155,406,298 0.209 1.001E709cg01328444 6 155,967,739 0.201 4.036E710cg22939394 6 155,999,688 0.177 9.628E709cg07292773 6 156,718,177 Island 0.165 3.765E711cg05225634 6 156,718,288 Island 0.166 7.926E709cg09056876 6 156,718,398 Island 0.220 2.935E708cg14987175 6 157,417,829 ARID1B;ARID1B;ARID1B Body;Body;Body 0.195 9.180E708cg12093241 6 157,465,138 ARID1B;ARID1B;ARID1B Body;Body;Body 0.195 5.295E711cg20396436 6 159,173,195 SYTL3 Body 0.199 1.477E708cg04837722 6 160,463,767 IGF2R Body 0.229 1.253E708cg01188509 6 160,509,295 IGF2R Body N_Shelf 0.188 1.691E710cg03742724 6 161,838,997 PARK2;PARK2;PARK2 Body;Body;Body 0.179 6.295E709cg04010446 6 162,311,879 PARK2;PARK2;PARK2 Body;Body;Body 0.194 4.794E710cg10464773 6 164,171,506 0.222 3.215E708cg16163174 6 164,506,197 0.154 3.996E708cg15733007 6 165,324,747 0.158 3.619E708cg21899640 6 168,609,219 N_Shelf 0.182 3.907E708cg25599473 6 169,001,953 SMOC2;SMOC2 Body;Body 0.204 9.179E708cg14806083 6 169,002,120 SMOC2;SMOC2 Body;Body 0.222 8.569E709cg22771904 6 169,051,407 SMOC2;SMOC2 Body;Body 0.204 8.880E708cg15792134 6 169,051,418 SMOC2;SMOC2 Body;Body 0.279 8.121E708cg10240139 6 169,605,570 0.173 3.945E708cg16805094 6 169,629,875 THBS2 Body N_Shore 0.245 6.663E709cg10309354 6 170,361,474 0.212 1.266E708cg03008093 6 170,361,827 0.176 2.799E711cg04452437 6 170,411,595 0.172 5.539E708cg13600257 6 170,449,417 N_Shelf 0.189 9.068E708cg25044186 6 170,494,475 S_Shelf 0.240 2.941E710cg02919368 7 143,012 0.216 1.166E708cg26552477 7 143,029 0.192 6.092E709cg12339133 7 1,031,174 S_Shore 0.170 1.486E709cg07690127 7 2,077,293 MAD1L1;MAD1L1;MAD1L1 Body;Body;Body 0.204 1.278E708cg13571479 7 2,077,345 MAD1L1;MAD1L1;MAD1L1 Body;Body;Body 0.167 6.807E709cg24418393 7 4,065,931 SDK1 Body 0.181 8.473E709cg25555505 7 4,791,054 FOXK1 Body N_Shelf 0.201 7.190E708cg09286367 7 5,535,692 MIR589;FBXL18 TSS200;Body S_Shore 0.253 1.270E708cg17419731 7 5,535,731 MIR589;FBXL18 TSS200;Body S_Shore 0.232 1.588E709cg00966405 7 5,535,748 MIR589;FBXL18 TSS1500;Body S_Shore 0.199 6.445E710cg10793101 7 5,665,002 RNF216;RNF216 Body;Body 0.162 2.273E709cg07899076 7 5,675,839 RNF216;RNF216 Body;Body 0.188 1.321E710cg23534345 7 5,678,706 RNF216;RNF216 Body;Body 0.160 3.663E708cg17212127 7 8,383,356 0.172 1.954E709cg17268726 7 10,976,748 NDUFA4 Body N_Shelf 0.213 5.128E710cg09287864 7 17,274,056 70.197 1.896E709cg04456219 7 17,274,337 70.193 7.573E708cg08993283 7 17,585,471 0.159 9.583E710cg21972431 7 17,812,356 0.172 1.740E708cg00713400 7 22,233,206 RAPGEF5 Body 0.225 3.681E710cg00872256 7 23,243,417 N_Shelf 0.158 1.698E709

cg07110854 7 23,525,412 0.165 7.789E710cg05210480 7 24,539,647 0.176 1.438E711cg27436603 7 24,772,300 DFNA5;DFNA5;DFNA5 5'UTR;Body;Body 0.235 1.218E708cg08549390 7 25,702,709 0.249 8.006E709cg00188704 7 27,140,797 HOXA2 Body N_Shelf 0.178 1.479E708cg03763508 7 27,140,942 HOXA2 Body N_Shelf 0.157 3.857E708cg13661519 7 27,141,088 HOXA2 Body N_Shelf 0.171 3.885E708cg06055873 7 27,142,204 HOXA2;HOXA2 1stExon;5'UTR N_Shore 0.235 3.813E709cg01217984 7 27,143,235 HOXA2 TSS1500 Island 0.236 2.825E708cg19432993 7 27,143,287 HOXA2 TSS1500 Island 0.212 5.189E709cg06166490 7 27,143,334 HOXA2 TSS1500 Island 0.247 6.964E709cg13985518 7 27,143,788 HOXA2 TSS1500 S_Shore 0.169 4.617E708cg14216068 7 27,146,445 HOXA3;HOXA3;HOXA3 3'UTR;3'UTR;3'UTR Island 0.244 4.031E708cg07153966 7 27,147,590 HOXA3;HOXA3;HOXA3 Body;Body;Body Island 0.257 7.043E708cg19048532 7 27,148,002 HOXA3;HOXA3;HOXA3 Body;Body;Body Island 0.166 6.686E708cg17800708 7 27,148,204 HOXA3;HOXA3;HOXA3 Body;Body;Body Island 0.188 2.787E710cg09591524 7 27,150,031 HOXA3;HOXA3;HOXA3 5'UTR;Body;Body Island 0.214 6.909E712cg02439266 7 27,150,042 HOXA3;HOXA3;HOXA3 5'UTR;Body;Body Island 0.214 1.260E710cg00899400 7 27,154,537 HOXA3;HOXA3;HOXA3 5'UTR;TSS1500;5'UTR N_Shore 0.239 3.166E711cg09469665 7 27,154,660 HOXA3;HOXA3;HOXA3 5'UTR;TSS1500;5'UTR N_Shore 0.159 1.179E708cg21556281 7 27,154,720 HOXA3;HOXA3;HOXA3 5'UTR;TSS1500;5'UTR N_Shore 0.159 1.116E708cg00318947 7 27,154,914 HOXA3;HOXA3;HOXA3 5'UTR;TSS1500;5'UTR N_Shore 0.181 2.131E708cg04351734 7 27,155,173 HOXA3;HOXA3 5'UTR;5'UTR Island 0.161 9.658E708cg19999161 7 27,155,358 HOXA3;HOXA3 5'UTR;5'UTR Island 0.239 8.997E709cg21134232 7 27,155,548 HOXA3;HOXA3 5'UTR;5'UTR S_Shore 0.223 9.885E711cg01027532 7 27,155,974 HOXA3;HOXA3 5'UTR;5'UTR S_Shore 0.166 7.000E710cg02627455 7 27,157,818 HOXA3;HOXA3 5'UTR;5'UTR S_Shelf 0.268 2.160E710cg12305431 7 27,157,855 HOXA3;HOXA3 5'UTR;5'UTR S_Shelf 0.245 2.574E708cg09798023 7 27,161,624 HOXA3 5'UTR N_Shore 0.333 6.477E709cg00431187 7 27,161,749 HOXA3 5'UTR N_Shore 0.368 5.290E709cg26297005 7 27,162,090 HOXA3 5'UTR Island 0.252 1.989E710cg04778178 7 27,162,294 HOXA3 5'UTR Island 0.349 8.616E709cg18430152 7 27,162,401 HOXA3 5'UTR Island 0.293 8.235E710cg19817912 7 27,162,768 HOXA3 5'UTR N_Shore 0.292 2.915E709cg00903308 7 27,177,068 N_Shore 70.253 6.381E709cg19816811 7 27188364 HOXA6 TSS1500 N_Shore 70.276 2.576E708cg23590202 7 27188770 HOXA6 TSS1500 N_Shore 70.282 5.222E708cg01414882 7 27,192,480 S_Shore 70.288 2.145E708cg02919960 7 27,192,549 S_Shore 70.163 6.664E708cg23690350 7 27,201,523 S_Shore 70.246 3.212E709cg08971667 7 27,201,728 S_Shore 70.357 2.635E710cg03217995 7 27,203,430 HOXA9 Body N_Shore 70.453 2.796E708cg21007852 7 27,203,546 HOXA9 Body N_Shore 70.427 3.559E709cg01819512 7 27,207,996 N_Shore 70.358 1.167E708cg02886033 7 27,208,114 N_Shore 70.436 9.912E709cg05303901 7 28,338,625 CREB5 TSS1500 0.159 6.383E708cg19638435 7 28,452,093 CREB5;CREB5 5'UTR;TSS200 S_Shelf 0.208 9.672E708cg11301281 7 28,513,286 CREB5;CREB5;CREB5 5'UTR;5'UTR;Body 0.168 2.034E709cg26483505 7 28,787,270 CREB5;CREB5;CREB5;CREB5 Body;Body;Body;Body 0.215 4.300E709cg06480353 7 30,209,180 70.157 2.841E708cg07884255 7 33,804,562 0.180 2.992E709cg07308257 7 36,265,036 EEPD1 Body 0.300 4.307E711cg02920176 7 36,404,389 KIAA0895;KIAA0895 Body;Body N_Shore 0.210 1.896E708cg06620605 7 36,488,448 ANLN Body 0.225 1.884E709cg23569180 7 37,955,508 SFRP4 Body N_Shore 0.160 2.211E709cg04748010 7 39,046,213 POU6F2;POU6F2 5'UTR;5'UTR 0.186 3.176E710cg00027114 7 42,740,486 0.169 5.118E711cg08306614 7 44,423,096 NUDCD3 3'UTR 0.177 1.187E708cg08245849 7 48,748,266 0.156 7.700E708cg19365527 7 49,951,783 VWC2 3'UTR 0.171 1.912E708cg01702225 7 55,084,424 N_Shore 0.207 9.468E709cg26055062 7 55,090,516 EGFR;EGFR;EGFR;EGFR Body;Body;Body;Body S_Shelf 0.250 1.952E710cg10078057 7 55,090,707 EGFR;EGFR;EGFR;EGFR Body;Body;Body;Body S_Shelf 0.181 9.191E708cg09802893 7 64,350,876 S_Shore 0.224 1.690E708cg04070140 7 65,604,635 CRCP;CRCP;CRCP;CRCP;CRCP Body;Body;Body;Body;Body 0.259 6.751E709cg05283379 7 68,157,097 0.160 1.363E708cg07993468 7 73,389,632 0.152 4.888E708cg12548057 7 73,389,660 0.199 2.499E708cg06901893 7 73,400,692 0.163 3.596E708cg22493372 7 73,631,888 LAT2;LAT2;LAT2 Body;Body;Body 70.199 9.059E710cg15143037 7 75,639,754 STYXL1 Body 0.242 1.932E708cg00732381 7 79,166,927 0.158 2.378E708cg18433146 7 80,231,599 CD36;CD36 1stExon;5'UTR 0.164 6.399E708cg07449753 7 83,057,120 SEMA3E Body 0.157 4.424E710cg09708066 7 87,044,236 ABCB4;ABCB4;ABCB4 Body;Body;Body 0.264 1.318E710cg06315606 7 87,564,812 ADAM22;ADAM22;ADAM22;ADAM22;ADAM22Body;Body;Body;Body;Body S_Shore 0.184 4.953E709cg09230376 7 92,090,785 0.191 2.917E711cg11998200 7 92,274,858 CDK6;CDK6 Body;Body 70.169 3.561E711cg03806175 7 98,577,593 TRRAP Body N_Shore 0.177 6.929E708cg11543304 7 98,729,543 SMURF1;SMURF1 Body;Body 0.174 5.970E709cg04548715 7 99,598,775 S_Shelf 0.178 9.584E708cg01667493 7 101,466,750 CUX1;CUX1;CUX1 Body;Body;Body 0.235 2.247E709cg08549332 7 101,558,461 CUX1;CUX1;CUX1 Body;Body;Body N_Shore 0.162 6.884E708cg07638450 7 101,796,416 CUX1;CUX1;CUX1 Body;Body;Body 0.194 4.965E708cg19370689 7 102,558,323 LRRC17;FBXL13;LRRC17;FBXL13 5'UTR;Body;5'UTR;Body 0.199 1.511E708cg24224501 7 102,566,723 LRRC17;FBXL13;LRRC17;FBXL13 5'UTR;Body;5'UTR;Body 0.162 7.983E711cg03942871 7 102,574,105 LRRC17;FBXL13;LRRC17;FBXL13 5'UTR;Body;5'UTR;Body 0.218 1.360E711cg08500417 7 102,574,445 FBXL13;LRRC17;FBXL13;LRRC17 Body;Body;Body;Body 0.230 1.257E709cg18108818 7 102,574,475 FBXL13;LRRC17;FBXL13;LRRC17 Body;Body;Body;Body 0.276 1.388E709cg20066782 7 102,574,504 FBXL13;LRRC17;FBXL13;LRRC17 Body;Body;Body;Body 0.275 9.359E711cg19275692 7 103,343,261 RELN;RELN Body;Body 0.207 3.778E711cg25388451 7 111,784,478 DOCK4 Body 0.185 1.826E710

cg19888684 7 112,002,922 0.202 1.489E708cg12018521 7 115,858,134 TES Body 0.163 4.226E708cg22567315 7 119,604,878 0.155 2.337E708cg12043048 7 123,771,105 0.231 1.108E709cg27134730 7 124,633,001 0.191 7.045E708cg25900614 7 126,079,083 GRM8;GRM8;GRM8 3'UTR;3'UTR;Body 0.208 5.755E710cg23722096 7 127,347,748 SND1 Body 0.205 1.929E709cg06761584 7 128,469,799 FLNC;FLNC TSS1500;TSS1500 N_Shore 0.153 5.737E709cg19229692 7 131,830,279 PLXNA4 Body 0.211 2.807E709cg17349632 7 131,830,544 PLXNA4 Body 0.181 3.662E708cg13617733 7 132,109,851 PLXNA4;PLXNA4 Body;Body 0.182 1.231E708cg25453914 7 132,737,623 CHCHD3 Body 0.185 1.470E708cg15709214 7 134,463,438 CALD1;CALD1;CALD1 TSS1500;TSS1500;TSS1500 0.254 6.309E708cg05557262 7 135,434,988 FAM180A TSS1500 0.155 5.382E708cg26480092 7 136,401,420 0.215 4.298E709cg21473741 7 138,436,009 ATP6V0A4;ATP6V0A4;ATP6V0A4 Body;Body;Body 0.175 2.395E708cg26975184 7 140,267,040 DENND2A Body 0.269 2.102E709cg10532908 7 142,555,548 EPHB6 5'UTR S_Shelf 0.232 6.436E709cg16752583 7 142,583,731 TRPV6 TSS1500 0.160 5.252E709cg02596233 7 150,970,209 SMARCD3;SMARCD3 Body;Body N_Shelf 0.187 2.604E709cg18237616 7 151,191,667 RHEB Body 0.185 1.539E709cg14838600 7 151,442,967 PRKAG2;PRKAG2 Body;Body 0.191 9.245E708cg23786812 7 156,296,516 0.330 8.446E708cg14338779 7 157,405,010 PTPRN2;PTPRN2;PTPRN2 Body;Body;Body Island 0.154 4.647E710cg13451497 7 158,191,008 PTPRN2;PTPRN2;PTPRN2 Body;Body;Body 0.249 2.231E709cg25070442 8 881,586 0.169 4.864E709cg12086014 8 1,103,183 N_Shore 0.215 6.012E709cg19845127 8 1,320,565 N_Shore 0.169 1.152E708cg11492536 8 1,777,477 ARHGEF10 5'UTR N_Shelf 0.242 9.198E709cg22511775 8 1,796,506 ARHGEF10 Body N_Shore 0.173 3.233E709cg10195336 8 1,895,007 ARHGEF10 Body S_Shore 0.177 1.474E709cg08753331 8 1,895,010 ARHGEF10 Body S_Shore 0.167 1.189E709cg21769514 8 2,743,697 0.169 5.198E710cg17817521 8 3,086,479 CSMD1 Body 0.280 3.352E708cg16785381 8 3,141,907 CSMD1 Body 0.241 2.890E708cg00631327 8 3,965,218 CSMD1 Body 0.192 1.691E709cg27598632 8 7,686,204 DEFB106B;DEFB106A Body;Body 0.201 6.952E709cg02520399 8 8,168,661 0.189 1.069E708cg25455865 8 8,960,015 0.158 1.040E709cg05445291 8 11,225,875 C8orf12;TDH TSS200;Body 0.200 4.128E710cg23181433 8 17,477,018 PDGFRL Body 0.185 5.952E709cg03649589 8 19,460,935 CSGALNACT1;CSGALNACT1;CSGALNACT1TSS1500;Body;5'UTR S_Shore 0.216 1.688E708cg24280945 8 19,461,068 CSGALNACT1;CSGALNACT1;CSGALNACT1TSS1500;Body;5'UTR S_Shore 0.228 4.451E708cg27132535 8 20,170,388 0.183 8.573E708cg13866190 8 22,499,776 FLJ14107;BIN3 TSS200;Body 0.180 2.050E710cg07892167 8 23,144,983 R3HCC1 TSS1500 N_Shore 70.187 7.503E709cg24911388 8 23,211,349 LOXL2 Body 0.185 1.433E708cg20227326 8 25,227,128 DOCK5 Body 0.215 4.298E708cg07666727 8 30,658,394 PPP2CB;PPP2CB Body;Body 0.199 9.929E708cg19418958 8 30,705,886 TEX15 1stExon 0.194 1.986E708cg17167045 8 33,380,282 0.259 2.240E710cg23205629 8 33,421,410 RNF122 Body N_Shelf 0.214 4.979E709cg16924776 8 38,570,745 0.223 5.042E712cg02669055 8 39,848,333 IDO2 Body 0.204 1.809E708cg17187438 8 41,016,113 0.230 3.088E710cg17500703 8 41,107,467 70.150 8.059E709cg03151165 8 41,107,543 70.184 1.752E708cg02154585 8 41,137,578 SFRP1 Body 0.244 1.308E708cg16498741 8 41,144,520 SFRP1 Body 0.275 5.433E709cg14904908 8 41,167,660 SFRP1 TSS1500 S_Shore 70.159 5.699E710cg06166767 8 41,167,848 SFRP1 TSS1500 S_Shore 70.171 2.309E708cg19656415 8 41,176,850 70.181 2.608E709cg13680246 8 42,013,960 AP3M2;AP3M2 Body;Body S_Shelf 0.239 4.111E710cg12054981 8 42,037,387 PLAT;PLAT Body;Body 70.151 1.411E710cg01419713 8 42,038,135 PLAT;PLAT Body;Body 0.268 7.587E710cg17813539 8 42,157,355 IKBKB Body 0.280 2.689E710cg03911745 8 49,486,641 0.241 9.185E709cg02090805 8 52,721,657 PXDNL Body 0.172 3.346E709cg21514857 8 52,721,802 PXDNL 1stExon 0.190 8.725E708cg10333144 8 54,628,500 ATP6V1H;ATP6V1H;ATP6V1H 3'UTR;3'UTR;3'UTR 0.272 1.305E708cg21544713 8 61,326,407 0.176 8.015E709cg10442355 8 61,326,412 0.175 2.398E709cg07050692 8 61,664,695 CHD7 Body 0.166 2.693E709cg27410091 8 66,711,941 PDE7A Body 0.210 2.996E708cg20036162 8 67,404,651 C8orf46 TSS1500 0.239 9.108E711cg26674558 8 67,405,257 C8orf46 TSS1500 0.221 3.672E709cg23704362 8 67,405,742 C8orf46;C8orf46 1stExon;5'UTR 0.206 2.393E711cg20207219 8 69,242,509 N_Shore 0.182 7.934E708cg11064454 8 74,363,469 STAU2;STAU2;STAU2;STAU2 Body;Body;Body;Body S_Shelf 0.170 4.641E709cg08185095 8 74,527,135 STAU2;STAU2;STAU2;STAU2;STAU2;STAU2;STAU2Body;Body;Body;Body;Body;Body;Body 0.217 1.044E709cg12992268 8 76,181,841 0.193 2.865E708cg23346544 8 80,731,144 70.203 1.799E708cg13155823 8 80,993,721 TPD52;TPD52;TPD52 Body;TSS1500;Body 0.257 2.430E709cg17191715 8 86,290,878 CA1;CA1;CA1;CA1 TSS1500;TSS1500;TSS1500;TSS1500 0.238 5.970E709cg05877990 8 94,241,979 0.197 1.182E708cg19032662 8 94,242,042 0.189 2.532E709cg06991732 8 94,934,036 PDP1;PDP1;PDP1;PDP1;PDP1 5'UTR;Body;5'UTR;Body;Body S_Shelf 0.278 3.961E710cg27415425 8 95,084,766 0.216 4.317E709cg26427135 8 95,266,905 GEM;GEM Body;Body 0.255 8.398E709cg25305774 8 95,459,857 RAD54B Body 0.205 2.077E708cg11192169 8 96,393,868 0.164 2.650E708cg23917009 8 96,813,193 0.216 7.261E710

cg06042148 8 97,138,161 70.182 1.998E710cg05690644 8 97,158,015 GDF6 Body Island 70.222 4.612E708cg15006881 8 97,158,052 GDF6 Body S_Shore 70.184 4.397E709cg12156944 8 97,162,506 GDF6 Body 70.161 8.855E710cg01673674 8 97,166,036 GDF6 Body N_Shelf 70.211 1.066E709cg26550710 8 97,167,878 GDF6 Body N_Shore 70.181 3.766E708cg08381274 8 97,169,621 GDF6 Body N_Shore 70.173 3.301E708cg06569139 8 101,117,949 RGS22 Body Island 0.223 5.106E708cg04225551 8 102,526,827 GRHL2 Body 0.153 5.953E708cg13405226 8 103,747,281 N_Shelf 0.209 3.743E710cg23312086 8 103,780,068 0.186 4.385E708cg11486078 8 103,981,066 0.226 7.952E710cg02641539 8 105,351,190 TM7SF4 TSS1500 70.170 5.348E710cg21295575 8 105,352,067 TM7SF4;TM7SF4 1stExon;5'UTR 70.172 1.714E709cg14084888 8 117,777,782 UTP23 TSS1500 N_Shore 0.187 5.236E708cg03134051 8 119,059,372 EXT1 Body 0.161 3.551E708cg16374656 8 119,124,790 EXT1 TSS1500 S_Shore 0.174 7.530E710cg09628488 8 122,598,941 0.157 7.119E708cg21597811 8 123,687,197 0.187 4.260E710cg23202949 8 124,519,807 FBXO32;FBXO32 Body;Body 0.155 1.028E708cg25883066 8 127,647,405 0.155 2.143E708cg16675872 8 130,253,618 0.206 3.734E709cg26980111 8 132,321,917 0.178 7.091E709cg02951514 8 134,115,347 TG;SLA;SLA Body;TSS200;TSS200 0.173 5.814E709cg03220363 8 134,115,661 TG;SLA;SLA Body;TSS1500;TSS1500 0.157 2.237E708cg10191240 8 134,230,101 WISP1;WISP1 Body;Body 70.158 1.742E709cg21602518 8 134,394,900 0.163 8.797E708cg00052385 8 134,580,580 ST3GAL1;ST3GAL1 5'UTR;5'UTR N_Shore 0.174 6.165E708cg03183540 8 134,931,756 70.167 9.054E710cg12865888 8 141,220,177 TRAPPC9;TRAPPC9 Body;Body 0.253 6.809E710cg06931405 8 141,668,936 PTK2;PTK2 3'UTR;3'UTR 0.272 4.404E710cg10138338 8 142,289,648 0.202 2.506E708cg03195377 8 142,289,782 0.154 4.265E708cg25471715 8 144,129,543 C8orf31 Body 0.154 8.895E708cg20680163 8 145,033,743 PLEC1;PLEC1 Body;Body 0.170 1.388E708cg01137471 9 841,340 DMRT1 TSS1500 N_Shore 70.156 4.748E708cg21215550 9 969,544 Island 70.245 1.964E708cg13837335 9 2,191,798 SMARCA2;SMARCA2 Body;Body 0.202 5.313E709cg06935438 9 4,116,989 GLIS3;GLIS3 Body;Body N_Shore 0.175 2.852E708cg13474488 9 26,722,560 0.182 5.570E708cg14232108 9 33,202,784 70.179 1.255E708cg13453589 9 33,850,099 UBE2R2 Body 0.156 4.510E708cg13668471 9 34,577,064 CNTFR;LOC415056;CNTFR 5'UTR;Body;5'UTR N_Shore 70.164 1.676E711cg21222007 9 38,055,200 SHB Body 0.184 6.908E709cg14425888 9 74,223,055 0.246 4.630E708cg14048465 9 82,308,107 TLE4 Body 0.193 1.772E710cg13513232 9 84,435,798 0.215 4.686E708cg13445230 9 89,422,493 0.168 9.271E709cg00296903 9 90,620,271 N_Shore 0.184 3.021E709cg14631576 9 95,140,430 CENPP Body 0.182 3.197E708cg13577194 9 95,378,173 IPPK Body 0.214 4.800E709cg14255700 9 95,378,254 IPPK Body 0.182 1.422E708cg02558684 9 96,936,826 MIRLET7A1 TSS1500 0.165 2.067E708cg01197831 9 97,355,941 FBP2 1stExon 0.193 2.783E709cg13402635 9 97,669,802 C9orf3 Body 0.252 1.834E708cg14208234 9 97,763,410 C9orf3 Body N_Shelf 0.249 2.048E708cg05621843 9 97,806,397 C9orf3 Body N_Shore 0.212 3.214E708cg00351472 9 97846551 MIR23B;C9orf3;MIR27B TSS1500;3'UTR;TSS1500 N_Shore 0.257 8.449E708cg20355301 9 97,848,107 C9orf3;MIR2471 3'UTR;TSS200 N_Shore 0.179 4.366E708cg09951047 9 97,848,306 C9orf3;MIR2471 3'UTR;Body Island 0.226 5.089E708cg13972491 9 97,848,736 C9orf3 3'UTR S_Shore 0.159 3.222E708cg14331316 9 99,139,396 SLC35D2 Body 0.186 1.721E709cg21191461 9 100,846,886 TRIM14;TRIM14;TRIM14;TRIM14 3'UTR;3'UTR;3'UTR;3'UTR N_Shelf 0.175 1.361E708cg14206056 9 110,797,033 0.152 2.636E709cg14325779 9 111,230,512 0.171 3.213E708cg14442329 9 111,754,142 CTNNAL1 Body 0.220 5.052E709cg13531977 9 112,013,420 EPB41L4B;EPB41L4B Body;Body 0.280 5.386E708cg14226212 9 113,530,240 MUSK;MUSK;MUSK Body;Body;Body 0.151 5.104E709cg14523204 9 116,359,818 RGS3;RGS3;RGS3;RGS3;RGS3 3'UTR;3'UTR;3'UTR;3'UTR;3'UTR 0.173 1.215E709cg14040871 9 116,970,845 COL27A1;MIR455 Body;TSS1500 0.163 7.865E708cg14076827 9 123,660,368 S_Shelf 0.184 1.278E708cg00403579 9 124,533,992 DAB2IP;DAB2IP Body;Body N_Shore 0.158 7.542E708cg03174228 9 124,658,583 TTLL11 Body N_Shore 0.157 4.783E708cg20864636 9 130,025,713 GARNL3 TSS1500 0.174 2.243E708cg01319323 9 131,789,189 SH3GLB2 Body N_Shore 0.162 2.613E708cg13803765 9 133,760,464 ABL1;ABL1 Body;Body Island 0.186 6.666E708cg20511797 9 133,760,878 ABL1;ABL1 Body;Body Island 0.168 8.059E708cg13993183 9 134,699,541 S_Shore 0.189 2.756E708cg13525877 9 135,681,852 C9orf98 Body 0.224 2.183E709cg14228756 9 137,609,455 COL5A1 Body 0.173 1.931E709cg13821972 9 138,387,195 C9orf116;C9orf116 3'UTR;3'UTR 0.171 1.780E709cg13669188 9 139,984,628 MAN1B1 Body S_Shelf 0.213 6.421E709cg05005968 10 436,077 DIP2C Body 0.255 5.696E708cg11573170 10 556,762 DIP2C Body 0.154 6.186E710cg15912031 10 639,935 DIP2C Body 0.165 3.432E709cg19976363 10 1,570,039 ADARB2 Body 0.229 5.539E711cg06028247 10 1,686,427 ADARB2 Body 0.164 7.073E708cg10542123 10 1,686,470 ADARB2 Body 0.330 9.359E710cg23131974 10 1,767,723 ADARB2 Body 0.179 3.084E708cg15228268 10 3,146,741 PFKP Body N_Shore 0.182 3.515E708cg05561696 10 3,149,796 PFKP Body S_Shore 0.150 6.909E708cg14915316 10 3,149,852 PFKP Body S_Shore 0.174 5.470E708

cg07876051 10 3,159,145 PFKP Body N_Shore 0.236 6.023E708cg13951697 10 3,581,101 0.191 6.361E709cg19591417 10 4,395,585 0.227 4.651E711cg19993680 10 5,576,748 0.160 3.604E708cg13855852 10 6,065,835 IL2RA Body 0.187 4.539E708cg24262870 10 7,536,500 0.168 9.534E708cg17160666 10 8,545,003 0.187 3.126E710cg11875044 10 8,546,509 0.243 2.358E709cg19051045 10 10,933,670 0.227 4.197E708cg03302448 10 11,046,334 CUGBP2 TSS1500 0.238 7.495E708cg14937228 10 14,562,035 FAM107B 3'UTR 0.153 5.179E709cg05335277 10 14,861,832 CDNF 3'UTR 0.231 1.080E709cg26872151 10 22,908,265 PIP4K2A Body 0.163 9.517E708cg16442712 10 24,539,322 KIAA1217;KIAA1217;PRINS;KIAA1217 Body;Body;Body;Body 0.223 6.439E709cg26680350 10 24,728,987 KIAA1217;KIAA1217;KIAA1217 Body;Body;Body 0.185 1.815E709cg07232003 10 28,971,331 BAMBI 3'UTR 0.244 1.703E708cg11801524 10 29,811,563 SVIL;SVIL Body;Body 0.162 7.199E708cg05559808 10 29,834,201 SVIL;MIR604;SVIL Body;TSS200;Body 0.181 1.578E708cg13101887 10 29,890,938 SVIL;SVIL 5'UTR;5'UTR 0.294 6.983E711cg09287650 10 29,981,216 SVIL 5'UTR 0.190 3.640E708cg18818498 10 30,016,831 SVIL 5'UTR 0.214 2.403E708cg04496895 10 30,020,140 SVIL 5'UTR N_Shelf 0.296 8.458E709cg14037546 10 30,029,921 S_Shelf 0.175 6.293E709cg22946615 10 30,257,569 0.161 1.313E709cg04829143 10 30,290,657 0.238 9.384E711cg17731973 10 31,108,190 0.264 2.854E709cg08764162 10 31,147,088 ZNF438;ZNF438;ZNF438;ZNF438;ZNF438;ZNF438;ZNF438;ZNF438Body;5'UTR;Body;5'UTR;Body;Body;5'UTR;Body 0.168 8.275E710cg01656216 10 31,273,710 ZNF438;ZNF438;ZNF438;ZNF438;ZNF438;ZNF438;ZNF438;ZNF4385'UTR;5'UTR;5'UTR;5'UTR;5'UTR;5'UTR;5'UTR;Body 0.165 8.990E708cg26732544 10 31,308,092 ZNF438;ZNF438;ZNF438;ZNF438;ZNF438;ZNF438;ZNF4385'UTR;5'UTR;5'UTR;5'UTR;5'UTR;5'UTR;Body 0.230 5.337E710cg04333785 10 31,446,813 0.157 1.917E708cg02093006 10 32,201,942 ARHGAP12 5'UTR 0.201 3.584E708cg03015672 10 32,216,066 ARHGAP12 5'UTR N_Shore 0.190 4.000E708cg09642378 10 32,216,101 ARHGAP12 5'UTR N_Shore 0.234 5.374E710cg19513484 10 33,748,942 0.189 9.444E708cg03157179 10 45,282,107 0.161 4.053E708cg13319266 10 45,406,681 TMEM72 TSS200 0.163 4.362E710cg16048421 10 45,675,577 0.183 7.121E708cg04556519 10 45,675,633 0.195 3.573E708cg05880248 10 48,432,664 GDF10 Body S_Shelf 70.168 1.705E709cg18907942 10 48,485,073 0.155 1.286E708cg06792952 10 50,103,551 WDFY4 Body 0.183 1.397E709cg27406618 10 50,341,989 FAM170B;FAM170B 1stExon;5'UTR S_Shore 0.207 1.825E708cg12771178 10 50,342,081 FAM170B TSS200 S_Shore 0.214 2.869E709cg07536328 10 51,592,253 TIMM23 3'UTR 0.205 6.233E708cg08641881 10 60,937,501 PHYHIPL;PHYHIPL Body;Body S_Shore 0.174 2.703E708cg24760597 10 61,828,486 ANK3;ANK3 Body;Body 0.206 1.193E708cg19109397 10 61,828,511 ANK3;ANK3 Body;Body 0.242 8.540E708cg04326091 10 62,438,045 0.254 2.493E709cg17423071 10 67,679,803 CTNNA3;CTNNA3 3'UTR;3'UTR 0.264 3.229E711cg01093854 10 70,362,422 TET1 Body 0.162 3.277E708cg05296777 10 73,829,074 SPOCK2 Body 0.229 2.137E708cg15013801 10 73,976,790 ASCC1;C10orf104 TSS1500;5'UTR S_Shore 0.151 3.645E708cg04702314 10 75,873,408 VCL;VCL Body;Body 0.185 6.025E709cg19368031 10 76,688,843 MYST4 Body 0.192 2.270E708cg12703333 10 76,962,548 0.166 1.082E708cg14207539 10 77,794,591 C10orf11 Body 0.208 3.380E710cg02987635 10 77,794,658 C10orf11 Body 0.169 1.805E708cg19346281 10 78,870,186 KCNMA1;KCNMA1;KCNMA1;KCNMA1 Body;Body;Body;Body 0.190 5.255E708cg05908691 10 78,870,221 KCNMA1;KCNMA1;KCNMA1;KCNMA1 Body;Body;Body;Body 0.217 1.090E710cg18436008 10 80,535,327 0.161 3.307E708cg08975445 10 82,402,662 SH2D4B;SH2D4B Body;Body 0.205 2.053E708cg27125177 10 85,956,635 PCDH21 Body S_Shore 0.204 1.131E708cg03107310 10 86,094,757 FAM190B 5'UTR 0.157 5.376E708cg15476602 10 88,545,743 BMPR1A 5'UTR 0.166 3.074E708cg19051661 10 88,588,785 BMPR1A 5'UTR 0.234 1.010E709cg14062537 10 93,272,333 LOC100188947;HECTD2 Body;3'UTR 0.173 5.615E709cg03417182 10 97,121,241 SORBS1;SORBS1;SORBS1;SORBS1;SORBS1;SORBS1;SORBS1Body;Body;Body;Body;Body;Body;Body 0.187 7.438E709cg02764250 10 97,145,217 SORBS1;SORBS1;SORBS1;SORBS1;SORBS1;SORBS1;SORBS1Body;Body;Body;Body;Body;Body;Body 0.214 3.245E709cg04248373 10 97,145,431 SORBS1;SORBS1;SORBS1;SORBS1;SORBS1;SORBS1;SORBS1Body;Body;Body;Body;Body;Body;Body 0.185 1.202E709cg10741308 10 97,175,272 SORBS1;SORBS1;SORBS1;SORBS1;SORBS1;SORBS1;SORBS1Body;Body;Body;Body;Body;Body;Body 0.165 4.021E710cg16004767 10 97,182,445 SORBS1;SORBS1;SORBS1;SORBS1;SORBS1;SORBS1;SORBS1Body;Body;Body;Body;Body;Body;Body 0.174 6.727E708cg25097946 10 97,200,985 SORBS1;SORBS1;SORBS1;SORBS1;SORBS1;SORBS1;SORBS15'UTR;TSS200;TSS200;TSS200;5'UTR;TSS200;TSS200 0.189 3.690E708cg14101359 10 97,300,930 SORBS1;SORBS1 5'UTR;5'UTR 0.193 8.777E709cg02662441 10 104,355,824 SUFU Body 0.238 4.213E708cg09830022 10 104,862,488 NT5C2;NT5C2 Body;Body 0.252 7.916E708cg12800012 10 105,600,413 SH3PXD2A Body 0.171 8.066E710cg04215238 10 105,841,897 COL17A1 5'UTR 0.197 7.760E708cg23013489 10 105,901,566 C10orf79 Body 0.199 8.031E709cg18515303 10 108,864,049 SORCS1;SORCS1 Body;Body 0.296 7.362E708cg18516365 10 111,721,749 0.175 1.583E708cg10646968 10 111,728,983 0.217 2.486E709cg16704246 10 112,594,670 RBM20 Body 0.181 6.726E710cg27408345 10 112,630,738 LOC282997;PDCD4;PDCD4 TSS200;TSS1500;TSS1500 N_Shore 0.222 5.224E710cg01246622 10 115,141,827 70.237 1.196E708cg25824127 10 115,926,060 C10orf118 5'UTR 0.171 3.716E708cg04055345 10 116,264,862 ABLIM1;ABLIM1;ABLIM1;ABLIM1 Body;Body;5'UTR;Body 0.184 9.615E708cg11812202 10 118,305,409 PNLIP TSS200 0.237 1.556E709cg23463205 10 118,305,444 PNLIP;PNLIP 5'UTR;1stExon 0.249 1.998E708cg27600794 10 118,349,430 PNLIPRP1 TSS1500 0.152 1.518E709cg17751430 10 118,350,377 PNLIPRP1 TSS200 0.254 4.603E709cg08629379 10 118,350,470 PNLIPRP1 TSS200 0.195 4.281E709cg07238926 10 118,350,475 PNLIPRP1 TSS200 0.225 1.789E709

cg23148094 10 118,350,608 PNLIPRP1 5'UTR 0.231 8.412E708cg09437460 10 119,042,696 PDZD8 3'UTR 0.220 6.567E708cg06787206 10 120,168,048 0.166 1.376E709cg26759179 10 121,125,566 GRK5 Body 0.176 2.485E709cg24919753 10 121,138,105 GRK5 Body 0.186 3.070E708cg02892577 10 121,181,759 GRK5 Body 0.204 3.398E708cg11404751 10 123,781,561 TACC2;TACC2 Body;Body 0.213 1.412E708cg18593374 10 126,302,546 LHPP;LHPP 3'UTR;3'UTR N_Shore 0.170 1.357E709cg24377826 10 126,376,113 FAM53B Body 0.255 2.662E709cg07906193 10 126,599,966 0.160 6.481E710cg08203849 10 126,683,336 CTBP2;CTBP2;CTBP2 Body;Body;Body N_Shelf 0.162 1.678E708cg02235497 10 127,941,989 ADAM12;ADAM12 Body;Body 0.228 1.905E708cg18698767 10 128,213,855 0.170 6.356E708cg18441102 10 128,975,183 FAM196A;DOCK1 5'UTR;Body S_Shore 0.162 1.332E708cg14731462 10 129,789,429 PTPRE 5'UTR 70.249 1.354E710cg13171643 10 131,324,189 MGMT Body 0.207 1.538E708cg07132942 10 131,569,335 0.212 3.151E709cg22773334 10 131,569,486 0.196 3.825E710cg09699225 10 134,957,290 S_Shore 0.212 3.716E709cg03906014 11 1,034,851 MUC6 Body Island 0.213 7.777E708cg04984852 11 1,463,935 BRSK2 Body N_Shore 0.161 9.472E708cg27261733 11 1,891,872 LSP1;LSP1;LSP1;LSP1 5'UTR;TSS1500;TSS1500;Body N_Shore 0.180 9.422E708cg02597644 11 1,898,970 LSP1;LSP1;LSP1;LSP1 5'UTR;5'UTR;Body;5'UTR 0.236 7.757E708cg03306615 11 2,292,890 ASCL2 TSS1500 Island 0.155 1.012E708cg14312661 11 3,064,385 CARS;CARS;CARS;CARS Body;Body;5'UTR;Body 0.171 4.732E708cg11042501 11 4,870,453 OR51S1 TSS200 0.199 7.588E710cg15781504 11 4,871,411 OR51S1 TSS1500 0.156 5.567E708cg26078436 11 5,265,992 HBBP1 TSS1500 0.269 2.912E709cg15290965 11 7,689,017 CYB5R2 Body 0.183 8.827E708cg27303733 11 8,007,457 EIF3F TSS1500 N_Shore 0.196 7.721E710cg05116719 11 8,007,597 EIF3F TSS1500 N_Shore 0.223 1.676E710cg26723045 11 9,042,581 SCUBE2;SCUBE2 3'UTR;3'UTR 0.156 2.775E710cg18441733 11 10,670,036 MRVI1;MRVI1;MRVI1;MRVI1 5'UTR;5'UTR;5'UTR;Body 0.189 1.970E708cg08769073 11 12,214,804 MICAL2 Body 0.192 3.297E709cg06796220 11 12,255,685 MICAL2 Body 0.228 1.065E708cg06829681 11 12,867,453 TEAD1 Body 0.192 4.656E711cg26707052 11 13,250,995 0.157 6.757E708cg13631318 11 13,987,766 SPON1 Body S_Shore 0.254 8.250E709cg12696488 11 14,128,237 SPON1 Body 0.222 2.723E709cg16426034 11 15,729,604 0.179 9.320E710cg02546690 11 17,834,480 SERGEF Body 0.157 2.142E708cg18593660 11 19,699,299 NAV2 Body 0.192 4.099E711cg12859429 11 20,046,011 NAV2;NAV2;NAV2;NAV2 Body;Body;Body;Body 0.176 2.326E708cg25410789 11 20,053,759 NAV2;NAV2;NAV2;NAV2 Body;Body;Body;Body 0.211 7.579E709cg02393617 11 20,087,765 NAV2;NAV2;NAV2;NAV2 Body;Body;Body;Body 0.250 3.613E709cg19826848 11 20,148,170 0.206 1.155E708cg07802401 11 26,354,057 ANO3 Body S_Shore 0.156 8.382E709cg18985738 11 27,160,935 0.172 7.104E708cg03763118 11 27,490,958 LGR4 Body N_Shelf 0.203 9.569E709cg22715531 11 27,492,378 LGR4 Body N_Shore 0.236 2.784E708cg17589284 11 28,422,367 0.335 3.245E710cg04509542 11 29,358,540 0.174 1.702E710cg07440264 11 33,744,977 CD59;CD59;CD59;CD59;CD59;CD59;CD59;CD595'UTR;TSS1500;5'UTR;TSS1500;5'UTR;TSS1500;TSS1500;5'UTR70.158 2.897E709cg15239179 11 35,229,448 CD44;CD44;CD44;CD44;CD44 Body;Body;Body;Body;Body 0.234 1.680E708cg09775841 11 36,394,356 PRR5L 5'UTR N_Shelf 0.239 2.468E709cg17401890 11 36,426,482 PRR5L;PRR5L;PRR5L;PRR5L Body;Body;Body;Body 0.192 1.883E708cg14223001 11 44,978,881 Island 0.168 4.424E708cg20709370 11 46,448,921 AMBRA1 Body 0.180 2.208E710cg26738160 11 47,459,510 RAPSN;RAPSN 3'UTR;3'UTR 0.178 2.190E709cg08980476 11 47,800,628 NUP160 3'UTR 0.238 7.465E709cg20107987 11 58,873,823 FAM111B;FAM111B;FAM111B TSS1500;TSS1500;TSS1500 N_Shore 0.169 2.935E708cg23618595 11 61,213,555 SDHAF2 3'UTR 0.189 1.715E709cg06266582 11 64,871,778 C11orf2 Body N_Shelf 0.177 7.286E708cg08293002 11 65,246,590 Island 0.170 6.879E708cg11525980 11 66,650,515 PC;PC;PC 5'UTR;5'UTR;5'UTR 0.173 9.213E708cg04732324 11 68,564,292 CPT1A;CPT1A Body;Body 0.203 8.529E709cg26906629 11 68,564,367 CPT1A;CPT1A Body;Body 0.210 8.820E709cg23031135 11 68,779,553 MRGPRF;MRGPRF 5'UTR;5'UTR S_Shore 0.171 2.436E708cg17042914 11 68,898,666 0.210 6.215E709cg16790827 11 68,970,629 0.203 6.264E710cg14574066 11 68,984,142 0.198 1.124E708cg08171022 11 70,185,278 PPFIA1;PPFIA1 Body;Body 0.151 2.402E709cg02011981 11 70,256,681 CTTN;CTTN Body;Body N_Shore 0.225 1.419E708cg04410987 11 70,282,745 0.278 2.267E708cg00447817 11 70,484,490 SHANK2;SHANK2 Body;Body 0.151 6.217E710cg21810373 11 70,917,159 SHANK2 5'UTR 0.241 2.466E709cg07999415 11 71,724,338 NUMA1 Body 0.201 6.866E708cg14705010 11 71,724,583 NUMA1 Body 0.211 5.985E708cg20887442 11 71,725,424 NUMA1 Body 0.228 7.052E709cg19502359 11 72,912,441 0.166 8.906E709cg11081272 11 78,130,236 GAB2 TSS1500 S_Shore 0.203 4.878E708cg04649598 11 78,803,866 ODZ4 5'UTR 0.228 4.697E708cg13572369 11 83,393,062 DLG2;DLG2;DLG2;DLG2 5'UTR;Body;Body;Body 0.209 5.702E708cg01062113 11 93,865,443 PANX1 Body S_Shelf 0.195 8.891E710cg15521790 11 95,889,454 MAML2 Body 70.180 3.010E708cg06560282 11 103,830,847 PDGFD;PDGFD Body;Body 0.205 3.172E708cg22768358 11 113,947,148 ZBTB16;ZBTB16 Body;Body 0.204 9.812E710cg16522260 11 114,958,426 0.167 2.686E708cg23531697 11 117,373,249 DSCAML1 Body 0.200 1.462E708cg16130802 11 118,773,983 BCL9L Body 0.210 1.767E709cg12926529 11 118,897,188 SLC37A4;SLC37A4;SLC37A4;SLC37A4;SLC37A4Body;Body;Body;Body;Body N_Shelf 0.200 2.543E708cg11586591 11 121,466,463 SORL1 Body 0.188 4.891E709

cg10107783 11 121,474,197 SORL1 Body 0.162 2.299E710cg26143540 11 121,542,234 0.257 7.569E711cg05678526 11 121,973,013 LOC399959 Body 0.195 1.349E708cg23602690 11 122,010,222 LOC399959 Body 0.264 8.494E710cg27212940 11 122,074,089 LOC399959 TSS1500 0.200 1.271E708cg13123165 11 122,106,236 0.231 5.317E708cg08181212 11 122,177,231 0.239 4.914E708cg21170682 11 122,205,382 0.182 4.185E709cg12236702 11 123,122,685 0.151 7.414E709cg13247967 11 123,487,358 GRAMD1B Body 0.210 5.926E710cg25128453 11 125,017,334 0.200 7.387E708cg02331196 11 125,094,760 PKNOX2 5'UTR 0.182 1.195E711cg05366909 11 125,333,752 FEZ1 Body 0.230 7.466E708cg03142039 11 125,931,532 CDON 5'UTR N_Shore 0.181 9.516E709cg05297666 11 128,400,310 ETS1 Body 0.214 7.814E708cg14801518 11 128,559,075 N_Shore 0.157 1.441E709cg04807669 11 128,636,703 FLI1;FLI1 Body;Body 0.152 5.037E712cg03231860 11 128,893,940 RICS;RICS;RICS 1stExon;Body;5'UTR 0.180 2.020E708cg09078622 11 130,115,733 ZBTB44 Body 0.209 5.792E708cg12182580 11 130,514,052 0.182 7.236E708cg27083553 11 131,487,041 NTM Body 0.159 4.372E709cg03910363 11 133,823,862 IGSF9B Body N_Shore 0.235 2.515E708cg07545846 11 133,940,520 JAM3 Body S_Shore 0.162 3.895E708cg04574152 12 5,965,794 ANO2 Body 0.214 9.067E713cg16433737 12 6,950,123 GNB3 5'UTR 0.241 2.905E708cg20090497 12 10,962,437 TAS2R9 1stExon 0.158 2.367E708cg08298946 12 13,301,010 0.168 9.405E709cg24390871 12 14,996,508 ART4 TSS200 0.188 2.977E710cg15733114 12 14,996,515 ART4 TSS200 0.169 1.921E708cg19532939 12 14,996,525 ART4 TSS200 0.162 3.512E710cg04228042 12 14,996,527 ART4 TSS200 0.236 8.707E711cg00253681 12 14,996,583 ART4 TSS200 0.202 4.819E710cg10047173 12 14,996,587 ART4 TSS200 0.224 4.401E710cg23028209 12 19,351,368 PLEKHA5;PLEKHA5 Body;Body 0.196 8.809E708cg05909891 12 19,565,983 0.212 1.602E709cg25629905 12 26,273,008 BHLHE41 3'UTR N_Shelf 0.182 1.187E710cg13515269 12 26,274,368 BHLHE41 3'UTR N_Shore 0.210 2.458E709cg16047471 12 26,274,563 BHLHE41 3'UTR N_Shore 0.172 7.561E709cg03413253 12 28,022,776 0.282 4.848E708cg22953685 12 31,771,672 S_Shelf 0.153 7.507E708cg03321196 12 32,192,489 0.162 3.441E708cg14802097 12 42,970,349 PRICKLE1 5'UTR 0.155 7.140E708cg11409510 12 42,981,814 PRICKLE1 5'UTR N_Shore 0.228 7.072E711cg09911173 12 43,196,754 0.183 7.685E708cg17052212 12 45,653,725 ANO6;ANO6;ANO6 Body;Body;Body 0.175 7.712E711cg25928510 12 45,749,440 ANO6;ANO6;ANO6;ANO6 Body;Body;Body;Body 0.178 1.506E708cg20883194 12 45,801,769 ANO6;ANO6;ANO6;ANO6 Body;Body;Body;Body 0.234 1.480E708cg16618389 12 46,865,385 0.210 6.343E711cg06372151 12 49,340,730 ARF3 5'UTR 0.287 1.641E709cg16424082 12 51,323,740 METTL7A Body 0.185 7.384E708cg19959477 12 52,610,273 LOC283404 Body 0.231 3.376E709cg07151565 12 53,869,995 PCBP2;PCBP2;PCBP2;PCBP2;PCBP2;PCBP2;PCBP2Body;Body;Body;Body;Body;Body;Body 0.167 1.080E709cg14639847 12 54,389,982 S_Shore 70.497 8.786E708cg16264616 12 54,390,824 S_Shore 70.287 1.495E708cg21618620 12 54,408,427 Island 70.186 1.833E708cg22198132 12 54,410,251 HOXC4;HOXC6;HOXC5 TSS1500;TSS1500;TSS1500 N_Shore 70.296 8.343E710cg14108840 12 54,410,302 HOXC4;HOXC6;HOXC5 TSS1500;TSS1500;TSS1500 N_Shore 70.200 8.754E709cg02491017 12 54,410,380 HOXC4;HOXC6;HOXC5 TSS1500;TSS1500;TSS1500 N_Shore 70.281 2.450E708cg23697546 12 54,424,085 HOXC4;HOXC5;HOXC6;HOXC6 5'UTR;Body;3'UTR;3'UTR N_Shore 70.344 9.734E710cg19186380 12 54,427,029 HOXC4;HOXC5;HOXC5 5'UTR;Body;1stExon Island 0.222 1.601E709cg05408649 12 54,446,019 HOXC4 5'UTR Island 70.268 6.345E708cg21493516 12 54,446,033 HOXC4 5'UTR Island 70.301 8.809E708cg27138204 12 54,446,100 HOXC4 5'UTR Island 70.244 5.286E708cg26201952 12 54,446,253 HOXC4;HOXC4 5'UTR;TSS1500 N_Shore 70.226 1.993E708cg22370252 12 54,446,289 HOXC4;HOXC4 5'UTR;TSS1500 N_Shore 70.203 4.348E709cg18473521 12 54,448,265 HOXC4;HOXC4 Body;Body S_Shore 0.263 5.807E710cg01213231 12 54,806,218 ITGA5 Body 0.154 5.293E708cg02363202 12 57,653,226 R3HDM2 Body 0.166 4.831E708cg23257289 12 62,490,552 FAM19A2 5'UTR 0.162 1.069E708cg19992375 12 65,067,877 RASSF3 Body 0.222 2.476E708cg12583076 12 65,082,713 RASSF3 Body 0.222 9.745E708cg25019961 12 66,996,175 GRIP1 Body 0.192 4.792E708cg24694549 12 67,072,769 GRIP1;GRIP1 1stExon;5'UTR 0.193 6.401E711cg10802444 12 67,072,951 GRIP1 TSS200 0.204 1.123E710cg09414535 12 67,073,022 GRIP1 TSS200 0.227 6.723E709cg10865238 12 67,073,062 GRIP1 TSS200 0.226 7.064E712cg06196314 12 68,304,774 0.246 1.712E709cg04987857 12 69,863,677 FRS2;FRS2 TSS1500;TSS1500 N_Shore 0.159 4.289E708cg09089894 12 75,043,991 0.159 1.082E709cg09266087 12 76,214,697 0.241 1.878E708cg07301061 12 80,663,711 0.197 1.172E708cg26263674 12 81,171,635 0.161 9.679E709cg12620645 12 92,899,917 70.215 6.350E709cg26584983 12 93,798,975 0.179 2.298E710cg09944400 12 95,043,227 TMCC3 Body N_Shore 0.190 1.982E709cg19004285 12 95,468,616 NR2C1;NR2C1;NR2C1 TSS1500;TSS1500;TSS1500 S_Shore 0.280 1.439E709cg26433955 12 96,558,950 0.215 9.271E710cg10812526 12 101,192,122 ANO4 5'UTR 0.191 5.344E709cg04004561 12 102,626,348 0.177 4.041E708cg02344784 12 104,178,138 NT5DC3 Body 0.200 3.685E708cg25738301 12 104,532,524 NFYB TSS1500 Island 0.153 4.494E708cg20245822 12 104,734,362 TXNRD1;TXNRD1;TXNRD1;TXNRD1;TXNRD1Body;Body;Body;Body;Body 0.207 5.369E712

cg08911237 12 104,750,418 0.212 5.141E710cg05957190 12 105,096,609 CHST11 Body 0.176 2.070E709cg07911905 12 105,096,644 CHST11 Body 0.190 4.184E708cg11117177 12 105,106,514 CHST11 Body 0.163 1.326E708cg11138719 12 106,307,091 0.243 1.014E708cg05654096 12 106,477,691 NUAK1 Body 70.172 1.123E708cg11417612 12 107,779,567 BTBD11 Body 0.180 9.508E708cg20111269 12 107,972,364 BTBD11 Body N_Shelf 0.200 5.901E710cg21500895 12 107,974,296 BTBD11;BTBD11 TSS1500;Body N_Shore 0.223 5.064E708cg21757872 12 107,974,453 BTBD11;BTBD11 TSS200;Body N_Shore 0.213 1.532E708cg23877008 12 109,896,967 KCTD10 Body 0.182 7.439E708cg08573038 12 110,399,302 GIT2;GIT2;GIT2;GIT2;GIT2;GIT2 Body;Body;Body;Body;Body;Body 0.202 3.245E709cg13557301 12 110,838,588 ANAPC7;ANAPC7 Body;Body N_Shelf 0.291 8.467E709cg19629079 12 111,403,841 0.184 6.253E710cg13235891 12 111,403,980 0.183 6.814E708cg06918928 12 111,404,204 0.220 3.074E711cg25953310 12 112,194,269 ACAD10;ACAD10 Body;Body 0.172 4.599E708cg09427417 12 112,194,570 ACAD10;ACAD10 3'UTR;3'UTR 0.255 2.729E709cg22040039 12 112,195,089 0.219 7.303E710cg25348927 12 112,306,624 MAPKAPK5;MAPKAPK5 Body;Body 0.278 3.026E708cg05489292 12 112,331,187 MAPKAPK5;MAPKAPK5 3'UTR;3'UTR 0.311 3.473E709cg11070030 12 114,232,702 0.185 3.362E709cg19698976 12 114,232,905 0.165 2.689E708cg24771877 12 114,234,123 0.204 1.468E710cg26470309 12 117,626,777 FBXO21;FBXO21 Body;Body N_Shore 0.185 6.917E711cg12213811 12 122,251,152 SETD1B Body S_Shore 0.167 3.569E708cg02347652 12 122,332,665 PSMD9 Body 0.208 6.998E709cg16948335 12 122,332,670 PSMD9 Body 0.219 5.555E709cg02013018 12 122,355,842 WDR66 TSS1500 N_Shore 0.305 9.488E709cg08464009 12 123,535,067 PITPNM2 5'UTR 0.280 5.094E708cg03061518 12 123,738,291 C12orf65;C12orf65 Body;Body 0.204 1.138E708cg15989926 12 124,607,875 0.165 8.871E708cg01408363 12 125,033,903 0.153 1.280E708cg26697255 12 130,347,526 TMEM132D Body S_Shelf 0.222 7.262E710cg23858650 12 130,502,255 0.199 1.855E709cg02506248 12 130,502,267 0.196 1.779E710cg22912997 12 130,502,283 0.158 2.885E708cg14623910 12 131,974,252 N_Shelf 0.162 1.584E709cg22695351 12 132,701,390 GALNT9 Body S_Shelf 0.227 2.433E708cg26894278 13 21,016,241 CRYL1 Body 0.209 6.044E708cg10787713 13 27,849,396 S_Shelf 0.180 1.366E708cg26650383 13 29,290,660 SLC46A3;SLC46A3 Body;Body N_Shelf 0.235 1.008E709cg11760099 13 30,096,184 SLC7A1 Body 0.181 1.919E708cg19928703 13 30,143,971 SLC7A1 5'UTR 0.155 2.633E709cg06531158 13 36,273,490 MIR548F5 Body 0.217 2.816E708cg22691986 13 39,358,777 FREM2 Body 0.178 1.234E709cg03623599 13 39,358,795 FREM2 Body 0.174 8.605E710cg17348791 13 39,358,839 FREM2 Body 0.157 1.688E709cg06447378 13 39,358,893 FREM2 Body 0.200 1.910E712cg18595137 13 39,458,059 FREM2 3'UTR 0.179 2.558E709cg07908654 13 41,631,052 N_Shelf 0.204 5.274E709cg06146977 13 43,469,464 EPSTI1;EPSTI1 Body;Body 0.169 2.820E709cg07627452 13 44,978,069 0.192 1.452E708cg21119127 13 46,297,726 0.160 9.778E709cg23869158 13 47,126,023 LRCH1;LRCH1;LRCH1 TSS1500;TSS1500;TSS1500 N_Shore 0.168 2.263E708cg02248565 13 47,272,723 LRCH1;LRCH1;LRCH1 Body;Body;Body 0.220 8.826E709cg00897799 13 47,367,897 ESD 5'UTR N_Shelf 0.198 6.377E708cg16512364 13 50,513,235 S_Shelf 0.227 2.210E709cg19349999 13 51,487,527 RNASEH2B;RNASEH2B Body;Body S_Shelf 0.161 3.117E708cg02887254 13 61,165,504 0.163 4.904E709cg14850477 13 72,334,420 DACH1;DACH1;DACH1 Body;Body;Body 0.179 7.070E708cg01450807 13 73,715,706 0.170 5.808E710cg07791585 13 73,826,369 0.175 2.208E708cg25462669 13 74,192,469 0.161 2.856E708cg12229775 13 74,315,385 KLF12 Body 0.183 8.451E709cg09075137 13 78,218,779 SCEL;SCEL;SCEL 3'UTR;3'UTR;3'UTR 0.161 7.573E709cg00185066 13 80,910,763 SPRY2 3'UTR N_Shelf 0.224 1.322E708cg18607411 13 80,911,808 SPRY2 Body N_Shore 0.185 4.257E708cg15158045 13 95,827,029 ABCC4;ABCC4 Body;Body 0.153 5.672E711cg08949428 13 98,451,284 0.266 1.355E709cg23954655 13 99,223,562 STK24 Body 70.180 6.747E709cg04821942 13 99,629,970 DOCK9;DOCK9;DOCK9;DOCK9 Body;Body;Body;Body 0.173 8.852E710cg16624069 13 99,630,210 DOCK9;DOCK9;DOCK9;DOCK9;DOCK9;DOCK9Body;5'UTR;1stExon;Body;5'UTR;1stExon 0.160 5.623E709cg21712331 13 99,630,489 DOCK9;DOCK9;DOCK9;DOCK9 Body;Body;TSS200;TSS200 0.168 1.197E708cg27518324 13 99,630,505 DOCK9;DOCK9;DOCK9;DOCK9 Body;Body;TSS200;TSS200 0.163 8.362E708cg25710107 13 101,187,390 A2LD1 TSS1500 S_Shelf 0.204 2.055E709cg25908283 13 107,124,524 0.155 6.797E708cg22179913 13 107,183,635 EFNB2 Body N_Shelf 0.235 6.289E708cg23125970 13 110,918,441 COL4A1 Body Island 0.161 3.853E708cg05629821 13 113,436,400 ATP11A;ATP11A Body;Body N_Shelf 0.164 6.831E710cg20006741 13 113,533,910 ATP11A;ATP11A 3'UTR;Body N_Shelf 0.285 2.396E709cg02622809 13 113,556,486 S_Shelf 0.196 1.567E708cg23146998 13 113,776,915 F10 TSS200 S_Shelf 0.158 4.949E708cg02747210 13 113,776,917 F10 TSS200 S_Shelf 0.155 1.326E708cg14534144 13 114,150,007 TMCO3 Body S_Shelf 0.232 4.245E708cg23167246 13 114,150,035 TMCO3 Body S_Shelf 0.233 3.867E708cg07190763 13 114,894,582 RASA3 Body N_Shelf 70.196 9.592E710cg00009349 14 22,674,549 0.186 1.084E709cg19577365 14 23,574,175 0.168 1.334E708cg01942776 14 30,920,008 0.178 2.949E708cg11103310 14 36,693,238 0.392 1.486E712cg01021196 14 38,340,164 0.165 1.958E708

cg01097663 14 42,300,132 LRFN5 5'UTR 0.160 1.107E708cg16127554 14 45,071,625 0.255 1.011E708cg04948194 14 45,840,127 0.154 4.772E709cg23244948 14 47,096,230 0.210 8.412E709cg17923947 14 50,584,005 C14orf138;SOS2;C14orf138 TSS1500;3'UTR;TSS1500 S_Shore 0.175 1.483E708cg08189198 14 51,290,136 NIN;NIN;NIN;NIN;NIN 5'UTR;5'UTR;5'UTR;1stExon;5'UTR 0.169 3.552E708cg16449219 14 51,290,169 NIN;NIN;NIN;NIN;NIN 5'UTR;5'UTR;5'UTR;1stExon;5'UTR 0.200 4.503E708cg10419590 14 53,344,150 FERMT2;FERMT2;FERMT2 Body;Body;Body 0.181 1.959E708cg01612824 14 56,313,920 0.169 2.074E709cg18148021 14 56,616,059 PELI2 Body 0.221 3.272E709cg26980937 14 56,991,775 0.194 1.140E708cg26333454 14 59,164,891 0.202 1.498E709cg26410821 14 59,660,101 DAAM1 5'UTR S_Shelf 0.241 1.850E710cg07518265 14 59,736,275 DAAM1 Body 0.212 1.037E708cg20064452 14 59,807,178 DAAM1 Body 0.252 8.202E708cg13043117 14 61,992,820 PRKCH Body 0.160 2.950E709cg05917797 14 62,075,110 0.171 1.369E708cg15857051 14 69,099,116 S_Shelf 0.151 6.411E709cg05410536 14 69,754,550 GALNTL1;GALNTL1 Body;Body 0.192 4.511E709cg02315926 14 70,140,384 KIAA0247 Body 70.216 2.438E709cg06173513 14 71,954,034 LOC145474 TSS1500 70.184 8.735E709cg18528073 14 72,270,991 0.248 6.070E709cg18674267 14 74,039,910 ACOT2 Body S_Shelf 0.151 2.137E708cg07531056 14 75,013,390 LTBP2 Body 0.188 6.257E708cg08189843 14 75,056,479 LTBP2 Body S_Shelf 0.208 2.271E708cg01910478 14 76,373,678 TTLL5 Body 0.174 7.195E709cg04127998 14 76,518,992 C14orf179;C14orf179 Body;Body 0.186 1.812E708cg14200631 14 77,041,210 0.177 4.268E709cg17009813 14 77,041,277 0.195 1.941E709cg18413218 14 77,371,470 70.194 7.141E710cg00707881 14 77,571,003 KIAA1737 5'UTR 0.234 2.106E708cg06941156 14 89,796,856 FOXN3;FOXN3 Body;Body 0.265 2.103E708cg13167443 14 92,196,238 CATSPERB 5'UTR 0.172 7.702E709cg01051583 14 93,196,072 LGMN;LGMN Body;Body 0.185 2.860E708cg03562528 14 94,423,943 ASB2 TSS200 0.171 9.976E708cg05863098 14 94,462,316 C14orf48;C14orf48;C14orf48 TSS1500;TSS1500;TSS1500 0.176 3.094E708cg16506185 14 94,463,488 C14orf48;C14orf48;C14orf48 TSS200;TSS200;TSS200 0.158 6.351E709cg23893332 14 94,576,048 IFI27;IFI27 TSS1500;TSS1500 0.152 1.322E709cg01546857 14 96,586,842 0.158 6.573E708cg23119063 14 99,506,767 0.287 4.722E708cg27059354 14 100,346,529 EML1;EML1 Body;Body 0.163 6.126E709cg03548062 14 101,158,251 0.279 4.303E709cg01755336 14 102,653,321 WDR20;WDR20;WDR20;WDR20 Body;Body;Body;Body 0.215 8.586E708cg01812400 14 104,179,095 XRCC3;XRCC3;XRCC3 5'UTR;5'UTR;5'UTR N_Shelf 0.156 5.016E710cg25089587 14 104,184,551 ZFYVE21 Body S_Shore 0.247 1.399E708cg25580656 14 104,197,160 ZFYVE21 Body S_Shelf 0.258 8.004E708cg14274357 14 105,251,402 AKT1;AKT1;AKT1 Body;Body;Body Island 0.186 5.279E708cg09501314 15 25,919,674 0.170 3.695E708cg24985060 15 25,920,220 0.266 5.119E709cg12315995 15 25,920,224 0.239 3.035E709cg12011926 15 29,037,099 S_Shelf 0.245 3.425E708cg17137426 15 33,080,435 FMN1 Body 0.175 4.069E710cg02328016 15 35,422,346 0.152 5.642E708cg26451373 15 37,100,941 CSNK1A1P;C15orf41;C15orf41 Body;3'UTR;3'UTR 0.156 4.199E708cg04339553 15 37,307,513 MEIS2;MEIS2;MEIS2;MEIS2;MEIS2;MEIS2;MEIS2Body;Body;Body;Body;Body;Body;Body 0.261 5.022E708cg16778156 15 37,402,581 N_Shore 70.156 9.464E709cg05151360 15 37,402,723 N_Shore 70.157 5.016E709cg03832697 15 38,228,220 TMCO5A 5'UTR 0.217 1.500E708cg02633229 15 40,674,878 C15orf23;C15orf23;C15orf23 TSS200;TSS200;TSS200 N_Shore 0.151 9.020E708cg00211489 15 40,826,026 MRPL42P5 TSS1500 0.160 6.995E709cg13780614 15 49,607,868 GALK2;GALK2 Body;Body 0.189 1.970E708cg10666761 15 55,909,920 PRTG 3'UTR 0.266 2.446E708cg17427305 15 57,881,059 N_Shelf 0.167 6.272E709cg05289698 15 59,908,160 GCNT3 5'UTR 0.166 3.117E708cg05641048 15 59,908,622 GCNT3 5'UTR 0.224 8.043E710cg23877385 15 59,908,652 GCNT3 5'UTR 0.213 1.359E708cg22538355 15 60,331,745 0.184 7.958E709cg22581200 15 60,666,575 ANXA2;ANXA2;ANXA2;ANXA2 Body;Body;Body;Body 0.163 1.477E708cg06367149 15 61,254,575 RORA Body 0.190 1.159E708cg00852705 15 62,090,739 0.189 5.415E709cg13852730 15 62,745,028 0.237 2.113E709cg04914221 15 63,116,514 TLN2 Body 0.179 4.146E708cg23931734 15 63,673,013 CA12;CA12 Body;Body N_Shore 0.179 7.261E709cg04192393 15 63,673,286 CA12;CA12 Body;Body N_Shore 0.240 3.003E708cg00067884 15 63,970,198 HERC1 Body 0.205 1.925E709cg03382306 15 66,097,959 0.204 5.894E708cg06835777 15 67,491,859 0.176 4.747E709cg07462279 15 67,494,178 AAGAB 3'UTR 0.280 1.905E710cg01837492 15 69,687,372 PAQR5;PAQR5 Body;Body 0.159 1.613E708cg05185738 15 70,371,992 MIR629;TLE3;TLE3;TLE3 TSS200;Body;Body;Body 0.217 3.270E709cg17972789 15 70,372,105 TLE3;TLE3;MIR629;TLE3 Body;Body;TSS1500;Body 0.211 2.344E709cg02852421 15 70,372,614 TLE3;TLE3;MIR629;TLE3 Body;Body;TSS1500;Body 0.179 2.927E708cg07229001 15 70,897,224 0.176 6.115E709cg26589665 15 71,623,290 THSD4 Body 0.174 1.083E708cg06052353 15 71,624,510 THSD4 Body 0.217 3.864E710cg24314662 15 72,071,616 THSD4 3'UTR 0.157 6.193E709cg17822978 15 72,073,485 THSD4 3'UTR 0.194 8.038E709cg27448447 15 72,093,348 0.173 2.311E708cg18219418 15 72,563,529 PARP6;PARP6 1stExon;5'UTR N_Shore 0.153 6.079E709cg08372668 15 74,221,840 LOXL1 Body S_Shore 0.152 4.119E708cg25677288 15 74,539,100 CCDC33 Body S_Shore 0.178 2.125E708cg26843110 15 74,935,742 EDC3;EDC3;EDC3 Body;Body;Body 0.199 6.181E709

cg06786153 15 78,327,011 TBC1D2B;TBC1D2B Body;Body 70.215 1.323E708cg20059377 15 78,369,232 TBC1D2B;TBC1D2B Body;Body N_Shore 70.174 7.926E708cg03938525 15 79,262,857 RASGRF1;RASGRF1;RASGRF1 Body;Body;Body 0.247 6.865E709cg07818978 15 81,823,340 0.165 2.193E709cg09868374 15 82,217,218 0.232 2.978E708cg19722706 15 83,732,977 BTBD1;BTBD1 Body;Body N_Shelf 0.159 2.015E708cg10275315 15 83,954,246 BNC1 TSS1500 S_Shore 70.162 6.229E708cg24189431 15 83,956,766 S_Shelf 0.206 3.035E710cg18637232 15 84,321,570 ADAMTSL3 TSS1500 N_Shore 0.173 9.705E708cg00894103 15 85,359,250 ALPK3 TSS1500 N_Shore 0.226 7.238E708cg18772882 15 88,616,079 NTRK3;NTRK3;NTRK3 Body;Body;Body 0.158 7.635E709cg24516362 15 91,838,184 SV2B;SV2B 3'UTR;3'UTR N_Shore 0.196 1.437E709cg08936516 15 93,210,555 0.152 1.478E708cg08766812 15 93,610,780 RGMA;RGMA;RGMA;RGMA;RGMA;RGMABody;Body;Body;Body;Body;Body S_Shore 0.153 4.249E708cg23734137 15 96,868,114 NR2F2 TSS1500 S_Shore 70.217 1.155E708cg14205663 15 96,872,827 NR2F2;NR2F2 TSS1500;Body N_Shore 70.247 1.016E708cg18761422 15 96,886,238 N_Shore 70.199 1.436E708cg15281710 15 96,890,452 S_Shore 70.226 3.419E708cg23742233 15 96,890,880 S_Shore 70.150 1.656E708cg19449948 15 96,891,476 N_Shelf 70.161 4.244E708cg10328844 15 98,417,731 LOC91948;LOC91948 TSS200;TSS200 0.182 1.503E708cg13496862 15 99,069,041 0.178 3.112E708cg11143674 15 99,069,100 0.163 2.301E708cg08112929 15 100,672,325 ADAMTS17 Body 0.264 7.684E708cg14397171 15 101,728,653 CHSY1 Body 0.188 6.717E710cg14496909 15 101,729,391 CHSY1 Body 0.239 1.642E708cg19987111 15 101,747,167 CHSY1 Body 0.220 2.431E709cg09695996 16 1,138,489 C1QTNF8 3'UTR N_Shore 0.207 9.041E709cg07360304 16 1,138,697 C1QTNF8 3'UTR N_Shore 0.175 1.608E709cg04418330 16 2,177,155 PKD1;PKD1 Body;Body Island 0.174 1.739E708cg02742281 16 3,027,577 PKMYT1;PKMYT1 Body;Body N_Shelf 0.161 3.980E709cg27111240 16 3,999,109 0.207 2.221E708cg06595211 16 3,999,188 0.260 4.392E710cg04122657 16 4,014,295 ADCY9 3'UTR N_Shore 0.245 2.102E710cg10371483 16 4,152,045 ADCY9 Body 0.179 5.943E711cg02374107 16 4,163,907 ADCY9 Body N_Shore 0.174 7.318E710cg07944396 16 7,382,514 A2BP1;A2BP1;A2BP1;A2BP1;A2BP1;A2BP1Body;TSS1500;TSS1500;Body;TSS1500;Body 0.282 2.049E711cg00480381 16 7,382,796 A2BP1;A2BP1;A2BP1;A2BP1;A2BP1;A2BP1;A2BP1;A2BP1;A2BP1Body;5'UTR;Body;1stExon;5'UTR;1stExon;1stExon;5'UTR;Body 0.186 4.233E708cg27623406 16 7,382,864 A2BP1;A2BP1;A2BP1;A2BP1;A2BP1;A2BP1;A2BP1;A2BP1;A2BP1Body;5'UTR;Body;1stExon;5'UTR;1stExon;1stExon;5'UTR;Body 0.222 8.704E709cg06513814 16 10,647,084 EMP2 5'UTR 70.213 2.989E709cg05731801 16 10,647,200 EMP2 5'UTR 70.177 3.507E711cg09712682 16 10,647,275 EMP2 5'UTR 70.168 8.844E710cg09684846 16 10,912,718 FAM18A TSS200 Island 0.227 3.996E708cg01105356 16 11,016,097 CIITA Body 0.193 2.584E708cg27581211 16 11,219,954 CLEC16A Body 0.186 6.011E708cg10364862 16 11,220,376 CLEC16A Body 0.175 1.418E708cg04359558 16 11,648,224 LITAF;LITAF;LITAF;LITAF Body;Body;Body;Body 0.278 3.782E710cg07380907 16 11,963,779 GSPT1;GSPT1;GSPT1 3'UTR;3'UTR;3'UTR 0.292 1.588E708cg02533339 16 14,403,040 MIR36571 TSS200 70.164 6.657E708cg00874605 16 14,569,598 PARN;PARN Body;Body 0.216 1.611E708cg27058221 16 14,766,421 PLA2G10 3'UTR 0.249 3.042E709cg06685590 16 15,818,816 NDE1;NDE1;MYH11;MYH11;MYH11;MYH113'UTR;3'UTR;Body;Body;Body;Body 0.180 1.968E708cg06503456 16 16,124,697 ABCC1;ABCC1;ABCC1;ABCC1;ABCC1 Body;Body;Body;Body;Body 0.255 1.063E708cg10024478 16 16,243,918 ABCC6 3'UTR 0.159 5.787E711cg06213876 16 16,357,187 NOMO3 Body 0.169 2.181E709cg02077068 16 19,872,240 GPRC5B Body 0.191 7.910E708cg02067239 16 22,776,055 0.215 2.587E708cg05632631 16 24,099,614 PRKCB;PRKCB Body;Body 0.164 6.591E708cg03607729 16 25,138,698 LCMT1;LCMT1 Body;Body 0.208 3.150E709cg27048684 16 27,791,167 KIAA0556 3'UTR 0.333 2.540E710cg27636914 16 27,791,184 KIAA0556 3'UTR 0.201 1.910E711cg26540647 16 27,791,248 KIAA0556 3'UTR 0.190 9.761E711cg08726667 16 28,573,379 CCDC101 5'UTR 0.201 1.630E710cg02964287 16 28,887,830 N_Shelf 0.150 2.130E709cg07710971 16 46,920,836 GPT2;GPT2 Body;5'UTR S_Shore 0.183 6.795E708cg02335656 16 49,845,969 ZNF423 Body 0.184 8.437E711cg04685962 16 50,583,729 NKD1 Body S_Shore 0.193 2.575E708cg02981942 16 54,574,605 0.174 8.224E711cg10417457 16 55,510,137 N_Shelf 0.195 1.400E711cg05724197 16 57,406,044 CX3CL1 TSS1500 0.171 2.869E708cg01096617 16 58,569,180 CNOT1 Body 0.211 2.314E708cg03995968 16 65,953,812 0.161 9.851E708cg00401972 16 66,400,404 CDH5 TSS200 0.162 2.283E709cg22319147 16 66,400,599 CDH5;CDH5 5'UTR;1stExon 0.187 4.623E710cg02843158 16 66,575,847 TK2 Body 0.179 8.356E708cg05966228 16 67,666,442 CTCF Body 0.178 1.900E710cg03052099 16 67,951,373 PSKH1 Body 0.180 4.645E708cg26924825 16 67,977,865 SLC12A4;SLC12A4;SLC12A4;LCAT;SLC12A4;SLC12A43'UTR;3'UTR;3'UTR;1stExon;3'UTR;3'UTR 0.153 1.485E709cg02564259 16 67,978,429 SLC12A4;SLC12A4;SLC12A4;SLC12A4;SLC12A4;LCAT3'UTR;3'UTR;3'UTR;3'UTR;3'UTR;TSS1500 0.162 2.963E709cg00415057 16 68,333,694 SLC7A6;SLC7A6 3'UTR;3'UTR 0.201 1.582E708cg07425824 16 69,451,547 0.191 5.394E708cg00963786 16 69,830,352 WWP2;WWP2 Body;Body 0.182 4.076E708cg08996445 16 70,700,420 MTSS1L Body S_Shelf 0.179 1.501E708cg09584711 16 72,096,944 HPR TSS200 0.171 2.537E709cg09699830 16 72,516,874 0.195 3.306E708cg16587832 16 77,834,140 VAT1L Body 0.187 3.373E710cg00479912 16 79,472,241 0.151 8.714E708cg03498081 16 80,061,357 70.165 6.112E708cg05887079 16 81,605,942 CMIP;CMIP Body;Body 0.192 1.107E709cg00864691 16 84,986,179 0.152 2.081E709cg01325465 16 85,123,554 KIAA0513 3'UTR 0.187 5.961E710cg00808935 16 85,215,140 0.157 8.206E708

cg06984848 16 85,320,722 Island 0.198 8.826E708cg05540639 16 85,352,976 0.212 9.728E708cg27219972 16 85,479,264 0.169 1.018E708cg07532353 16 85,608,659 0.194 7.915E709cg01984854 16 85,879,072 Island 0.270 1.649E708cg10150962 16 86,404,379 0.220 5.652E708cg10284425 16 86,457,686 0.152 6.049E709cg07230359 16 86,466,427 0.197 3.577E711cg02857325 16 86,564,928 MTHFSD;MTHFSD;MTHFSD;MTHFSD;MTHFSD;MTHFSD;MTHFSD3'UTR;3'UTR;3'UTR;Body;3'UTR;Body;3'UTRN_Shore 0.152 7.626E708cg09119881 16 86,591,940 S_Shelf 0.240 1.793E708cg03638489 16 86,592,652 S_Shelf 0.230 2.202E708cg07304536 16 86,987,635 70.227 8.716E709cg06286618 16 86,987,702 70.210 1.336E709cg05479109 16 87,077,864 0.167 2.542E708cg07126126 16 87,159,035 0.193 4.487E709cg07347205 16 87,159,274 0.150 7.072E709cg03923640 16 87,174,624 0.216 2.701E708cg07474266 16 87,481,957 ZCCHC14 Body 0.224 5.971E709cg01783679 16 88,096,868 BANP;BANP Body;Body 0.162 3.821E708cg08894593 16 88,910,841 GALNS Body S_Shelf 0.161 1.811E708cg02167055 16 89,019,403 CBFA2T3 Body 0.159 6.979E708cg16616467 16 89,642,914 CPNE7;CPNE7 Body;Body Island 0.208 7.016E708cg20142501 17 791,118 NXN Body 0.187 6.577E708cg18229049 17 791,217 NXN Body 0.187 2.849E708cg20945055 17 836,474 NXN Body 0.151 3.867E708cg04080005 17 1,057,444 ABR;ABR Body;5'UTR 0.165 7.450E710cg23214985 17 1,537,890 SCARF1;SCARF1;SCARF1;SCARF1;SCARF13'UTR;Body;3'UTR;Body;3'UTR N_Shore 0.177 4.469E711cg22791545 17 1,924,319 RTN4RL1 Body N_Shelf 70.151 1.146E708cg06217769 17 2,126,306 SMG6;SMG6 Body;Body 0.185 5.837E709cg26927232 17 2,135,631 SMG6;SMG6 Body;Body 0.218 4.343E708cg25855001 17 2,886,346 RAP1GAP2;RAP1GAP2 Body;Body 0.174 5.478E708cg13785068 17 3,416,273 0.182 9.529E708cg15477040 17 4,124,222 ANKFY1;ANKFY1 Body;Body N_Shore 0.200 1.650E708cg26089877 17 4,498,445 SMTNL2;SMTNL2 Body;Body Island 70.192 1.095E709cg22271113 17 8,370,397 NDEL1;NDEL1 3'UTR;3'UTR 0.252 1.107E709cg06310294 17 8,370,483 NDEL1;NDEL1 3'UTR;3'UTR 0.176 7.382E709cg12633739 17 8,370,548 NDEL1;NDEL1 3'UTR;3'UTR 0.264 6.161E710cg12403329 17 8,371,203 NDEL1;NDEL1 3'UTR;3'UTR 0.263 1.455E710cg18041123 17 8,380,351 MYH10 Body Island 0.229 2.811E708cg22588546 17 8,382,941 MYH10 Body S_Shelf 0.184 1.378E708cg16618637 17 8,424,250 MYH10 Body 0.258 4.268E708cg21322120 17 9,150,052 0.193 8.668E708cg19720377 17 9,732,025 GLP2R Body 0.185 3.526E710cg08102611 17 9,989,409 GAS7 Body 0.179 3.151E708cg06800222 17 10,195,469 0.171 3.164E709cg21977507 17 12,145,856 0.197 5.265E709cg09731113 17 12,567,873 MYOCD;MYOCD TSS1500;TSS1500 N_Shore 0.179 2.976E708cg10257905 17 12,568,092 MYOCD;MYOCD TSS1500;TSS1500 N_Shore 0.173 1.366E708cg15328609 17 12,571,977 MYOCD;MYOCD Body;Body S_Shelf 0.262 4.078E708cg14330868 17 12,631,363 MYOCD;MYOCD;MYOCD Body;Body;Body 0.172 1.242E708cg08898866 17 13,941,263 0.198 1.478E708cg27621897 17 13,965,860 0.153 2.813E708cg12146763 17 14,483,597 0.188 2.414E708cg06960881 17 15,168,483 PMP22;PMP22 1stExon;5'UTR S_Shore 0.158 6.540E709cg03242666 17 15,168,570 PMP22;PMP22 1stExon;5'UTR S_Shelf 0.166 7.657E709cg24482246 17 19,548,992 N_Shelf 0.214 3.430E708cg15159588 17 26,672,798 TNFAIP1 3'UTR 0.214 5.114E708cg09906647 17 26,939,344 FLJ25006;LOC645851 Body;TSS1500 0.161 7.348E711cg17065262 17 27,506,097 MYO18A;MYO18A 5'UTR;5'UTR N_Shore 0.168 4.379E709cg08723956 17 28,174,981 SSH2 Body 0.185 1.038E709cg27390206 17 28,585,657 BLMH Body 0.171 1.492E708cg00748958 17 30,348,814 LRRC37B 1stExon 0.154 5.195E708cg08535474 17 35,149,318 0.165 2.591E709cg16822666 17 35,656,660 ACACA;ACACA;ACACA;ACACA;ACACA;ACACA;ACACA5'UTR;Body;5'UTR;Body;1stExon;1stExon;Body 0.180 1.624E709cg01760189 17 35,656,896 ACACA;ACACA;ACACA;ACACA;ACACA TSS1500;Body;TSS1500;Body;Body 0.236 5.384E709cg02048377 17 37,219,764 PLXDC1 3'UTR 0.201 1.836E708cg08469845 17 39,676,096 KRT15 TSS1500 0.151 3.831E708cg08893117 17 41,327,244 NBR1;NBR1;NBR1 5'UTR;5'UTR;5'UTR S_Shelf 0.225 2.005E708cg09965388 17 42,275,123 ATXN7L3;ATXN7L3 Body;Body N_Shore 0.204 2.147E708cg03383006 17 42,992,924 GFAP;GFAP TSS200;TSS200 S_Shelf 0.248 6.182E708cg21944455 17 42,994,269 GFAP;GFAP TSS1500;TSS1500 0.170 4.792E708cg10369888 17 46,138,081 NFE2L1 3'UTR S_Shore 0.186 2.433E708cg15255390 17 46,632,154 HOXB3 5'UTR Island 0.170 1.855E709cg10820084 17 48,267,144 COL1A1 Body 0.184 3.416E708cg07160420 17 48,863,591 0.278 3.735E709cg09486367 17 49,826,437 CA10;CA10;CA10 Body;Body;Body 0.193 5.703E709cg06483820 17 55,167,149 AKAP1 5'UTR S_Shelf 0.157 7.995E708cg07159758 17 55,474,061 MSI2;MSI2 Body;Body 0.234 2.091E709cg08788712 17 55,604,163 MSI2;MSI2 Body;Body 0.299 1.946E708cg13466917 17 57,116,416 TRIM37;TRIM37 Body;Body 0.336 3.237E710cg16200799 17 60,717,850 MRC2 Body 0.176 2.695E709cg17050097 17 60,783,168 MARCH10;MARCH10 Body;Body S_Shore 0.179 4.802E708cg14622443 17 60,886,038 41343 TSS1500 S_Shore 0.173 2.824E709cg16963138 17 60,886,079 41343 TSS1500 S_Shore 0.239 1.636E710cg22137075 17 61,046,563 S_Shelf 0.222 8.871E708cg06136432 17 63,530,161 AXIN2 Body N_Shelf 0.226 3.468E710cg02161011 17 63,530,270 AXIN2 Body N_Shelf 0.167 5.437E710cg12255061 17 63,533,152 AXIN2 Body Island 0.222 2.109E708cg09119854 17 63,550,766 AXIN2 Body 0.223 3.206E710cg03650282 17 64,451,448 PRKCA Body 0.202 2.897E708cg01768814 17 65,437,355 PITPNC1;PITPNC1 Body;Body 70.165 9.883E710cg05505961 17 66,375,071 ARSG Body 0.154 3.263E710

cg07909444 17 67,585,094 0.160 1.324E708cg02868298 17 68,066,712 0.183 6.095E708cg26893699 17 68,851,883 0.194 2.536E708cg13544294 17 70,188,923 0.150 9.258E709cg02976539 17 72,757,302 SLC9A3R1 Body 0.150 2.466E709cg22807402 17 73,269,154 SLC25A19;SLC25A19;SLC25A19 3'UTR;3'UTR;3'UTR S_Shore 0.183 6.125E709cg05446253 17 73,498,127 CASKIN2;CASKIN2 Body;Body Island 0.202 1.141E708cg09662798 17 73,498,302 CASKIN2;CASKIN2 Body;Body Island 0.213 1.716E709cg17029237 17 73,555,445 LLGL2;LLGL2;LLGL2 Body;Body;Body N_Shelf 0.188 4.875E709cg26205890 17 73,955,839 ACOX1;ACOX1 Body;Body 0.164 6.585E710cg04813119 17 75,181,254 SEC14L1;SEC14L1;SEC14L1;SEC14L1;SEC14L1Body;Body;TSS200;Body;Body 0.160 8.109E709cg06761530 17 75,373,219 SEPT9;SEPT9;SEPT9;SEPT9;SEPT9 5'UTR;5'UTR;Body;Body;Body S_Shelf 0.230 2.524E708cg21830368 17 75,373,327 SEPT9;SEPT9;SEPT9;SEPT9;SEPT9 5'UTR;5'UTR;Body;Body;Body S_Shelf 0.182 2.524E709cg05337753 17 75,373,407 SEPT9;SEPT9;SEPT9;SEPT9;SEPT9 5'UTR;5'UTR;Body;Body;Body S_Shelf 0.192 1.339E709cg23994112 17 75,373,457 SEPT9;SEPT9;SEPT9;SEPT9;SEPT9 5'UTR;5'UTR;Body;Body;Body S_Shelf 0.160 1.590E708cg06380320 17 75,399,899 SEPT9;SEPT9;SEPT9;SEPT9;SEPT9 Body;Body;Body;Body;Body S_Shore 0.159 6.505E708cg13523731 17 76,607,622 0.176 1.033E708cg18910127 17 77,361,667 HRNBP3 5'UTR 0.182 6.708E708cg05745871 17 78,125,475 S_Shelf 0.231 1.807E709cg11648740 17 78,411,819 FLJ35220;FLJ35220 3'UTR;3'UTR 0.190 2.464E708cg22878693 17 78,755,604 RPTOR;RPTOR Body;Body 0.240 4.093E709cg18469159 17 78,755,841 RPTOR;RPTOR Body;Body 0.245 1.188E708cg12434898 17 78,817,642 RPTOR;RPTOR Body;Body N_Shore 0.153 9.939E709cg11620135 17 79,011,140 BAIAP2;BAIAP2;BAIAP2;BAIAP2 Body;Body;Body;Body S_Shore 0.264 4.094E708cg15867652 17 79,011,277 BAIAP2;BAIAP2;BAIAP2;BAIAP2 Body;Body;Body;Body S_Shore 0.190 5.539E708cg22442557 17 79,011,352 BAIAP2;BAIAP2;BAIAP2;BAIAP2 Body;Body;Body;Body S_Shore 0.198 7.286E708cg10063663 17 79,038,712 BAIAP2;BAIAP2;BAIAP2;BAIAP2 Body;Body;Body;Body 0.219 8.523E710cg03139388 17 79,394,412 BAHCC1 Body S_Shore 0.154 1.624E708cg04147593 17 80,196,719 SLC16A3;SLC16A3;SLC16A3 Body;Body;Body S_Shore 70.172 1.440E708cg26937943 18 8,800,248 KIAA0802 Body 0.201 2.627E708cg00525392 18 19,744,123 N_Shore 0.171 1.104E708cg14880184 18 19,758,221 GATA6 Body S_Shore 0.237 8.066E711cg26136497 18 20,735,537 CABLES1;CABLES1;CABLES1 Body;Body;TSS1500 0.192 6.701E709cg13313047 18 20,735,648 CABLES1;CABLES1;CABLES1 Body;Body;TSS200 0.213 1.200E708cg24964110 18 20,735,672 CABLES1;CABLES1;CABLES1 Body;Body;TSS200 0.241 1.982E709cg20759047 18 20,735,693 CABLES1;CABLES1;CABLES1 Body;Body;TSS200 0.216 5.106E709cg23878906 18 29,304,818 S_Shore 0.175 2.295E708cg25331919 18 47,092,023 LIPG Body S_Shelf 0.188 3.031E710cg18085435 18 55,400,167 ATP8B1 TSS1500 0.160 2.572E708cg00781795 18 55,815,677 NEDD4L;NEDD4L;NEDD4L;NEDD4L;NEDD4L;NEDD4L;NEDD4L5'UTR;TSS1500;TSS1500;Body;TSS1500;Body;TSS1500 0.161 1.412E709cg27555092 18 56,296,354 ALPK2 TSS200 0.152 3.237E711cg03319695 18 59,156,627 CDH20 TSS1500 0.324 2.244E708cg13861749 18 70,533,078 NETO1;NETO1;NETO1 Body;TSS200;TSS200 N_Shore 0.172 2.175E708cg27107963 18 76,629,213 S_Shelf 0.193 2.666E708cg10826956 19 1,098,580 S_Shelf 0.183 1.973E708cg00423871 19 4,827,986 TICAM1 5'UTR N_Shelf 0.170 1.916E708cg16009129 19 6,106,379 RFX2;RFX2 5'UTR;5'UTR N_Shelf 0.170 2.795E708cg01504784 19 6,414,019 KHSRP 3'UTR N_Shore 0.182 2.303E708cg24851260 19 7,297,992 S_Shelf 0.174 5.892E710cg04747007 19 7,585,845 ZNF358 3'UTR N_Shore 0.178 1.133E709cg08329004 19 10,364,849 MRPL4;MRPL4;MRPL4 Body;Body;Body S_Shore 0.190 4.389E708cg22550815 19 11,276,529 KANK2;KANK2 3'UTR;3'UTR 0.172 5.167E708cg10767662 19 13,127,729 NFIX Body S_Shelf 0.176 2.313E708cg14723977 19 15,532,806 WIZ 3'UTR N_Shelf 0.204 5.438E708cg02410867 19 16,198,843 TPM4;TPM4 Body;Body 0.266 1.131E709cg07988171 19 16,199,419 TPM4;TPM4 Body;Body 0.168 6.379E709cg08523456 19 16,226,402 RAB8A Body S_Shelf 0.169 3.618E708cg15438314 19 17,190,397 MYO9B;MYO9B 5'UTR;5'UTR S_Shelf 0.170 8.834E708cg03635171 19 46,650,879 IGFL2;IGFL2 TSS1500;TSS200 0.172 1.528E711cg10833393 19 46,651,227 IGFL2;IGFL2 5'UTR;TSS1500 0.171 8.504E711cg10222534 19 48,958,894 KCNJ14;KCNJ14 1stExon;5'UTR S_Shelf 0.175 6.916E709cg19503826 19 56,187,810 EPN1;EPN1;EPN1 TSS200;5'UTR;5'UTR S_Shore 0.203 1.953E708cg00449482 19 56,187,915 EPN1;EPN1;EPN1 TSS200;5'UTR;5'UTR S_Shore 0.163 2.037E708cg04969203 20 3,232,711 C20orf194 3'UTR S_Shelf 0.179 3.438E709cg16606773 20 19,955,806 RIN2 Body Island 0.200 7.233E708cg24626310 20 25,276,739 ABHD12;PYGB Body;Body 0.164 6.845E709cg17941312 20 25,381,464 0.171 1.641E708cg01047613 20 31,446,682 EFCAB8 TSS200 0.207 3.648E708cg27605858 20 32,034,667 S_Shelf 0.165 8.556E710cg19909713 20 36,033,306 SRC;SRC 3'UTR;3'UTR N_Shore 0.202 5.867E709cg11806178 20 39,319,929 Island 70.212 8.822E708cg22849543 20 46,997,755 LOC284749 Body N_Shelf 0.216 1.941E709cg14468280 20 47,862,976 ZNFX1 3'UTR 0.164 4.093E708cg16632346 20 48,530,472 SPATA2;SPATA2 5'UTR;TSS200 N_Shore 0.180 7.552E708cg19221489 20 48,530,654 SPATA2;SPATA2 TSS1500;5'UTR N_Shore 0.152 6.317E708cg10140309 20 49,548,661 ADNP;ADNP TSS1500;TSS1500 S_Shore 0.155 2.935E710cg14160518 20 50,418,952 SALL4;SALL4 1stExon;5'UTR Island 0.152 8.905E708cg23676369 20 54,987,020 CASS4;CASS4;CASS4;CASS4 TSS1500;TSS1500;TSS200;TSS1500 70.153 6.836E708cg12670073 20 56,287,532 PMEPA1 TSS1500 S_Shelf 0.172 2.689E711cg03401480 20 57,087,179 APCDD1L Body N_Shelf 0.302 3.293E708cg05357152 20 61,049,813 GATA5 Body Island 70.181 1.219E708cg08015883 20 61,049,884 GATA5 Body Island 70.360 3.232E709cg03689129 20 61,053,355 S_Shore 70.204 7.921E710cg18856925 20 62,555,227 DNAJC5 5'UTR S_Shelf 0.202 1.084E708cg27478961 21 27,944,586 CYYR1 Body N_Shore 70.176 1.034E708cg22871721 21 37,761,363 CHAF1B Body S_Shelf 0.194 6.208E708cg13538551 21 39,493,881 DSCR8;DSCR8;DSCR8;DSCR8;DSCR8;DSCR4Body;Body;Body;Body;Body;TSS1500 0.160 4.392E709cg19793640 21 40,822,862 SH3BGR;SH3BGR 5'UTR;TSS1500 0.158 6.523E709cg00362657 21 44,876,670 Island 70.297 1.365E708cg27484412 21 44,876,687 Island 70.239 2.098E708cg25418528 22 21,381,565 P2RX6;P2RX6 3'UTR;3'UTR 0.159 8.697E709cg10628201 22 21,977,597 UBE2L3;UBE2L3;UBE2L3 Body;3'UTR;Body 0.297 9.949E709

cg22882543 22 22,868,585 ZNF280A Body 0.230 1.289E709cg25590527 22 24,979,254 GGT1 TSS1500 0.223 4.237E710cg13825083 22 24,979,367 GGT1 TSS1500 0.158 1.604E709cg13382768 22 24,979,436 GGT1 TSS1500 0.159 1.680E709cg09338412 22 24,979,554 GGT1 TSS200 0.175 1.322E710cg21881327 22 24,979,569 GGT1 TSS200 0.155 2.193E710cg07350057 22 24,979,660 GGT1 TSS200 0.152 4.171E710cg22106220 22 25,758,637 LRP5L;LRP5L TSS200;5'UTR S_Shelf 0.165 5.056E708cg00187327 22 28,191,781 MN1 Body N_Shore 0.191 4.934E708cg11986861 22 29,284,199 ZNRF3 5'UTR S_Shelf 0.162 4.069E708cg17505852 22 30,003,603 NF2;NF2;NF2;NF2;NF2;NF2;NF2;NF2;NF2Body;Body;Body;Body;Body;Body;Body;Body;BodyS_Shelf 0.164 8.646E709cg15823100 22 32,027,580 PISD TSS1500 S_Shore 0.151 9.211E708cg25036527 22 36,123,779 APOL5 Body 0.159 1.957E708cg25564144 22 36,135,459 RBM9;RBM9;RBM9;RBM9;RBM9;RBM93'UTR;3'UTR;3'UTR;3'UTR;3'UTR;3'UTR 0.221 6.995E710cg17652424 22 38,574,118 PLA2G6;PLA2G6 5'UTR;5'UTR N_Shelf 0.184 6.965E710cg00542127 22 41,592,676 N_Shore 0.188 2.669E708cg15331500 22 41,779,351 TEF;TEF Body;Body S_Shore 0.156 4.745E709cg02803775 22 41,937,252 POLR3H;POLR3H;POLR3H Body;Body;Body N_Shelf 0.197 4.015E709cg01311181 22 44,577,181 PARVG;PARVG;PARVG;PARVG;PARVG;PARVG5'UTR;Body;TSS200;TSS200;Body;5'UTR 70.160 1.623E709cg19603134 22 44,577,240 PARVG;PARVG;PARVG;PARVG;PARVG;PARVG5'UTR;Body;TSS200;Body;Body;5'UTR 70.190 6.568E709cg07072704 22 45,899,736 FBLN1;FBLN1;FBLN1;FBLN1 Body;Body;Body;Body S_Shore 0.178 1.770E708cg19916740 22 46,275,064 N_Shore 70.243 2.826E708cg18826958 22 46,275,235 N_Shore 70.152 1.458E708cg19764731 22 46,459,024 S_Shore 0.200 9.437E708cg00921237 22 49,496,760 N_Shore 0.199 6.556E709cg09131332 22 50,482,045 TTLL8 Body N_Shore 0.183 1.699E708cg08660915 22 50,523,790 MLC1;MLC1;MLC1 1stExon;5'UTR;TSS200 70.154 2.760E708cg18093120 22 50,523,955 MLC1;MLC1;MLC1 1stExon;5'UTR;TSS200 70.163 4.014E708

Supplementary,Table,6.,Functional,annotation,analysis,of,genes,mapping,to,atherosclerosis,grade:,,age:,and,sex:independent,aortic,dm:CpGs

Content&of&table:&GO&terms;&pathways;&tissue&specificity

GO&termsCategory Term Count % Fisher&exact&p>

valueGenes Fold&

EnrichmentGOTERM_MF_FATGO:0008092~cytoskeletal&protein&

binding57 0.73 2.70E>09 TLN2,&UTRN,&IQGAP2,&MTSS1L,&VCL,&NDE1,&LMOD1,&EGFR,&KCNMA1,&PARVG,&

FMNL2,&BAIAP2,&FLNC,&FLNB,&GPR98,&EPB41L2,&FMN1,&RAB11FIP5,&NCK2,&CAPN10,&NDEL1,&TNS1,&ARL8A,&ARL8B,&ABLIM1,&SHROOM3,&CALD1,&SSH2,&ANLN,&MYO9B,&EPB41L4B,&DAAM1,&CAPZB,&DAAM2,&TPM4,&NUMA1,&SORBS1,&PFN4,&MACF1,&PKD2,&WIPF1,&AFAP1,&SYNPO,&PHACTR1,&PHACTR2,&NF2,&MYO1B,&MAP1B,&GAS7,&ANXA2,&PKNOX2,&LSP1,&MYO10,&FYN,&SVIL,&MYH10,&FEZ1

2.36

GOTERM_CC_FATGO:0015629~actin&cytoskeleton 36 0.46 2.29E>08 CTNNAL1,&ABLIM1,&PRKCZ,&PDLIM7,&TLN2,&CALD1,&UTRN,&FERMT2,&IQGAP2,&ANLN,&MYO9B,&CAPZB,&TPM4,&VCL,&MACF1,&PFN4,&SORBS1,&PKD2,&WIPF1,&SYNPO,&SH3PXD2A,&MYO1B,&SLC9A3R1,&FLNB,&GAS7,&CTNNA3,&CTNNA2,&LSP1,&FMN1,&EPB41L2,&PKNOX2,&MYO10,&CLIC4,&SVIL,&MYO18A,&MYH10

2.91

GOTERM_MF_FATGO:0003779~actin&binding 40 0.51 1.11E>07 ABLIM1,&SHROOM3,&TLN2,&CALD1,&SSH2,&UTRN,&IQGAP2,&ANLN,&MYO9B,&MTSS1L,&DAAM1,&CAPZB,&DAAM2,&TPM4,&VCL,&MACF1,&PFN4,&SORBS1,&WIPF1,&AFAP1,&SYNPO,&PARVG,&KCNMA1,&EGFR,&PHACTR1,&FMNL2,&PHACTR2,&MYO1B,&MAP1B,&FLNC,&GAS7,&FLNB,&PKNOX2,&LSP1,&FMN1,&EPB41L2,&MYO10,&TNS1,&SVIL,&MYH10

2.57

GOTERM_BP_FATGO:0030030~cell&projection&organization

38 0.49 7.02E>06 RTN4RL1,&GDF7,&LPAR3,&DSCAML1,&MTSS1L,&EPHB3,&CAPZB,&SCARF1,&EPHB2,&VCL,&SEMA5A,&ALCAM,&AKT1,&ATP2B2,&PTK2,&HOXA2,&MACF1,&CD44,&ANK3,&PRKCA,&EGFR,&DNM3,&RAB8A,&PLA2G10,&BAIAP2,&MAP1B,&GAS7,&GPR98,&CTNNA2,&NCK2,&SEMA6A,&NDEL1,&RASGRF1,&RELN,&VCAN,&MTOR,&MYH10,&FEZ1

2.24

GOTERM_CC_FATGO:0016323~basolateral&plasma&membrane

25 0.32 1.95E>05 ENPP1,&TLN2,&FERMT2,&NEDD9,&ADORA1,&VCL,&COL17A1,&PTK2,&SORBS1,&CD44,&MACF1,&ANK3,&STK39,&AFAP1,&TES,&EGFR,&PARVG,&LPP,&ITGA2,&CTNNA2,&TNS1,&CASS4,&ITGA5,&NOTCH4,&SLC9A1

2.68

GOTERM_BP_FATGO:0016310~phosphorylation 64 0.82 1.99E>05 NUAK1,&GDF7,&GDF6,&PKMYT1,&LPAR3,&ADORA1,&AKT1,&PSKH1,&STK39,&FGF2,&FRS2,&PRKCA,&EGFR,&CTBP1,&STK24,&PIK3C2B,&MYLK4,&PKN2,&ATP6V1H,&PRKCH,&CDK6,&PRKCE,&PRKCB,&MAP4K3,&ROR1,&PDGFRA,&CAMK1,&RELN,&UGP2,&PRKCZ,&MAPKAPK5,&BRSK2,&EPHB3,&SDHAF2,&SRC,&EPHB2,&GALK2,&EPHB6,&PTK2,&MUSK,&VRK2,&SPEG,&DCLK2,&NDUFA4,&PTPRE,&NIN,&ALPK3,&ALPK2,&TGFBR2,&NPR1,&OXSR1,&NTRK3,&PLK2,&FYN,&TGFBR3,&GRK5,&MTOR,&TSSK1B,&IKBKB,&IPPK,&ABL1,&ATP6V0A4,&PIP4K2A,&BMPR1A

1.73

GOTERM_BP_FATGO:0022610~biological&adhesion 58 0.74 1.99E>05 CTNNAL1,&TLN2,&IGFBP7,&FERMT2,&LY9,&VCL,&CD96,&CDH20,&WISP1,&CD44,&LOXL2,&SPON1,&EGFR,&PARVG,&CNTNAP5,&SDK1,&PTPRU,&GPR98,&CTNNA3,&CTNNA2,&CD36,&RELN,&VCAN,&ADAM12,&PPFIA1,&DSCAML1,&ITGB5,&NEDD9,&CX3CL1,&CDH5,&SCARF1,&SRC,&SEMA5A,&ALCAM,&COL17A1,&SORBS1,&COL27A1,&PKD2,&PKD1,&THBS2,&DPT,&TNXB,&LPP,&CNKSR3,&HSPG2,&ITGA2,&COL5A1,&ITGA9,&CASS4,&FREM2,&ITGA5,&CDON,&CD58,&ADAM22,&PDZD2,&ABL1,&NTM,&FEZ1

1.79

GOTERM_BP_FATGO:0007155~cell&adhesion 58 0.74 2.00E>05 CTNNAL1,&TLN2,&IGFBP7,&FERMT2,&LY9,&VCL,&CD96,&CDH20,&WISP1,&CD44,&LOXL2,&SPON1,&EGFR,&PARVG,&CNTNAP5,&SDK1,&PTPRU,&GPR98,&CTNNA3,&CTNNA2,&CD36,&RELN,&VCAN,&ADAM12,&PPFIA1,&DSCAML1,&ITGB5,&NEDD9,&CX3CL1,&CDH5,&SCARF1,&SRC,&SEMA5A,&ALCAM,&COL17A1,&SORBS1,&COL27A1,&PKD2,&PKD1,&THBS2,&DPT,&TNXB,&LPP,&CNKSR3,&HSPG2,&ITGA2,&COL5A1,&ITGA9,&CASS4,&FREM2,&ITGA5,&CDON,&CD58,&ADAM22,&PDZD2,&ABL1,&NTM,&FEZ1

1.79

GOTERM_BP_FATGO:0006793~phosphorus&metabolic&process

74 0.95 2.25E>05 PDP1,&NUAK1,&GDF7,&GDF6,&PKMYT1,&LPAR3,&ADORA1,&AKT1,&PSKH1,&STK39,&FGF2,&FRS2,&PRKCA,&EGFR,&CTBP1,&STK24,&PIK3C2B,&PTPRN2,&MYLK4,&PKN2,&ATP6V1H,&PRKCH,&CDK6,&PTPRU,&PRKCE,&PRKCB,&MAP4K3,&ROR1,&PDGFRA,&CAMK1,&RELN,&UGP2,&PRKCZ,&STYXL1,&ENPP1,&ENPP3,&MAPKAPK5,&SSH2,&BRSK2,&EPHB3,&ACP1,&SDHAF2,&SRC,&EPHB2,&GALK2,&EPHB6,&PTK2,&MUSK,&VRK2,&SPEG,&PPP2CB,&DCLK2,&NDUFA4,&PTPRE,&NIN,&ALPK3,&ALPK2,&TGFBR2,&EPM2A,&NPR1,&OXSR1,&NTRK3,&PLK2,&FYN,&TGFBR3,&GRK5,&MTOR,&TSSK1B,&IKBKB,&IPPK,&ABL1,&ATP6V0A4,&PIP4K2A,&BMPR1A

1.65

GOTERM_BP_FATGO:0006796~phosphate&metabolic&process

74 0.95 2.25E>05 PDP1,&NUAK1,&GDF7,&GDF6,&PKMYT1,&LPAR3,&ADORA1,&AKT1,&PSKH1,&STK39,&FGF2,&FRS2,&PRKCA,&EGFR,&CTBP1,&STK24,&PIK3C2B,&PTPRN2,&MYLK4,&PKN2,&ATP6V1H,&PRKCH,&CDK6,&PTPRU,&PRKCE,&PRKCB,&MAP4K3,&ROR1,&PDGFRA,&CAMK1,&RELN,&UGP2,&PRKCZ,&STYXL1,&ENPP1,&ENPP3,&MAPKAPK5,&SSH2,&BRSK2,&EPHB3,&ACP1,&SDHAF2,&SRC,&EPHB2,&GALK2,&EPHB6,&PTK2,&MUSK,&VRK2,&SPEG,&PPP2CB,&DCLK2,&NDUFA4,&PTPRE,&NIN,&ALPK3,&ALPK2,&TGFBR2,&EPM2A,&NPR1,&OXSR1,&NTRK3,&PLK2,&FYN,&TGFBR3,&GRK5,&MTOR,&TSSK1B,&IKBKB,&IPPK,&ABL1,&ATP6V0A4,&PIP4K2A,&BMPR1A

1.65

GOTERM_CC_FATGO:0030054~cell&junction 46 0.59 2.72E>05 PRKCZ,&SHROOM3,&PANX1,&TLN2,&GRIP1,&FERMT2,&UTRN,&NEDD9,&CDH5,&VCL,&PRR7,&PTK2,&COL17A1,&MACF1,&CD44,&SORBS1,&SV2B,&SV2A,&AFAP1,&DLG2,&DPP4,&SYNPO,&TES,&PARVG,&PHACTR1,&CTBP2,&NF2,&LPP,&CNKSR3,&TANC1,&ITGA2,&PTPRU,&SHANK2,&CTNNA3,&CTNNA2,&ABCB4,&CADPS,&FMN1,&CASS4,&TNS1,&P2RX6,&STXBP5,&RAPSN,&ITGA5,&PDZD2,&PMP22

1.93

GOTERM_BP_FATGO:0048598~embryonic&morphogenesis

32 0.41 3.55E>05 SHROOM3,&PRRX1,&DSCAML1,&ZBTB16,&ATP2B2,&RGMA,&SPRY2,&HOXA2,&CHD7,&HOXA3,&MACF1,&HOXA6,&HOXC4,&CHST11,&HOXA9,&FBN2,&FRS2,&PPAP2B,&ODZ4,&NF2,&TGFBR2,&HSPG2,&MBNL1,&MECOM,&ZNF358,&HOXB3,&SALL4,&CDON,&PBX1,&TXNRD1,&EXT1,&BMPR1A

2.26

GOTERM_BP_FATGO:0006468~protein&amino&acid&phosphorylation

55 0.71 3.73E>05 NUAK1,&GDF7,&GDF6,&PKMYT1,&LPAR3,&ADORA1,&AKT1,&PSKH1,&STK39,&FRS2,&FGF2,&EGFR,&PRKCA,&CTBP1,&STK24,&MYLK4,&PKN2,&PRKCH,&CDK6,&PRKCE,&PRKCB,&MAP4K3,&ROR1,&PDGFRA,&CAMK1,&RELN,&PRKCZ,&MAPKAPK5,&BRSK2,&EPHB3,&SRC,&EPHB2,&EPHB6,&MUSK,&PTK2,&VRK2,&SPEG,&DCLK2,&PTPRE,&ALPK3,&NIN,&ALPK2,&TGFBR2,&NPR1,&OXSR1,&NTRK3,&PLK2,&FYN,&TGFBR3,&MTOR,&TSSK1B,&GRK5,&ABL1,&IKBKB,&BMPR1A

1.78

GOTERM_CC_FATGO:0005856~cytoskeleton 95 1.22 4.83E>05 CTNNAL1,&MAD1L1,&GFAP,&PDLIM7,&TTLL8,&TLN2,&FERMT2,&UTRN,&TTLL5,&IQGAP2,&ADORA1,&TTLL11,&VCL,&AKT1,&SPRY2,&NDE1,&CTTN,&PSKH1,&ANK3,&STK39,&LMOD1,&LRRFIP1,&ADCY10,&DLG2,&PARVG,&SH3PXD2A,&MICAL2,&UBR4,&TANC1,&FLNC,&SLC9A3R1,&FLNB,&DCTN4,&SCEL,&CTNNA3,&TACC2,&CTNNA2,&EPB41L2,&FMN1,&TNS1,&NDEL1,&EML1,&NAV1,&CLIC4,&KRT15,&PLA2G6,&ARL8A,&ARL8B,&MYO18A,&ABLIM1,&PRKCZ,&SHROOM3,&LITAF,&CALD1,&SSH2,&NEDD9,&ANLN,&MYO9B,&EPB41L4B,&DNAH7,&CAPZB,&TPM4,&STAU2,&DNAH6,&PTK2,&NUMA1,&MACF1,&SORBS1,&PFN4,&PPP2CB,&PKD2,&WIPF1,&TRAF5,&AFAP1,&SYNPO,&DNM3,&NIN,&NF2,&MYO1B,&MAP1B,&LMNA,&SHANK2,&GAS7,&LSP1,&RASSF3,&PKNOX2,&MYO10,&CASS4,&P2RX6,&RAPSN,&SVIL,&MAP4,&ABL1,&MYH10,&FEZ1

1.50

GOTERM_CC_FATGO:0030055~cell>substrate&junction 17 0.22 4.93E>05 PARVG,&TLN2,&LPP,&FERMT2,&NEDD9,&ITGA2,&VCL,&PTK2,&COL17A1,&TNS1,&CASS4,&MACF1,&SORBS1,&CD44,&ITGA5,&AFAP1,&TES

3.31

GOTERM_BP_FATGO:0007167~enzyme&linked&receptor&protein&signaling&pathway

34 0.44 5.00E>05 FGF18,&CD8A,&LTBP2,&GDF7,&GDF6,&EPHB3,&SRC,&EPHB2,&AKT1,&MUSK,&EPHB6,&PTK2,&SORBS1,&DGKD,&FRS2,&FGF2,&EGFR,&PLAT,&PTPRE,&NIN,&BAIAP2,&TGFBR2,&PTPRU,&EPS15,&NTRK3,&NCK2,&ARF4,&PDGFRA,&ROR1,&GDF10,&TGFBR3,&SMURF1,&BAMBI,&BMPR1A

2.15

GOTERM_CC_FATGO:0042995~cell&projection 56 0.72 5.33E>05 PDLIM7,&TTLL8,&TLN2,&UTRN,&TTLL5,&ADORA1,&TTLL11,&AKT1,&ATP2B2,&CTTN,&ANK3,&KCNMA1,&OPA1,&SH3PXD2A,&BAIAP2,&CDK6,&SLC9A3R1,&CTNNA3,&CTNNA2,&NDEL1,&RASGRF1,&CLIC4,&GRM8,&GRM7,&RELN,&CATSPERB,&PANX1,&CALD1,&NEDD9,&MYO9B,&DNAH7,&CAPZB,&ALCAM,&PTK2,&NUMA1,&PEX19,&PKD2,&PKD1,&SYNPO,&NGEF,&DNM3,&RAB8A,&NF2,&MAP1B,&ITGA2,&PARK2,&GAS7,&DOCK4,&SEMA6A,&P2RX6,&ITGA5,&SVIL,&MTOR,&LRP2,&ATP6V0A4,&MYH10

1.75

GOTERM_MF_FATGO:0004672~protein&kinase&activity 52 0.67 5.49E>05 NUAK1,&LGMN,&PRKAG2,&PKMYT1,&AKT1,&PSKH1,&STK39,&EGFR,&PRKCA,&STK24,&MYLK4,&PKN2,&PRKCH,&CDK6,&PRKCE,&PRKCB,&MAP4K3,&IGF2R,&PDGFRL,&ROR1,&PDGFRA,&CAMK1,&RELN,&PRKCZ,&MAPKAPK5,&BRSK2,&EPHB3,&SRC,&EPHB2,&EPHB6,&MUSK,&PTK2,&VRK2,&SPEG,&DCLK2,&ALPK3,&NIN,&ALPK2,&TGFBR2,&NPR1,&OXSR1,&NTRK3,&CASS4,&PLK2,&FYN,&TGFBR3,&MTOR,&TSSK1B,&GRK5,&ABL1,&IKBKB,&BMPR1A

1.79

GOTERM_CC_FATGO:0005912~adherens&junction 20 0.26 8.67E>05 PARVG,&SHROOM3,&NF2,&TLN2,&LPP,&FERMT2,&NEDD9,&ITGA2,&CTNNA3,&CTNNA2,&VCL,&FMN1,&PTK2,&CASS4,&TNS1,&SORBS1,&CD44,&ITGA5,&AFAP1,&TES

2.81

GOTERM_BP_FATGO:0030036~actin&cytoskeleton&organization

25 0.32 1.23E>04 PRKCZ,&SHROOM3,&PDLIM7,&CALD1,&FERMT2,&SSH2,&NEDD9,&MYO9B,&DAAM1,&DAAM2,&CAPZB,&PFN4,&SORBS1,&WIPF1,&FMNL2,&TNXB,&NF2,&FLNB,&GAS7,&EPB41L2,&FMN1,&NCK2,&CAPN10,&ABL1,&MYH10

2.39

GOTERM_BP_FATGO:0048812~neuron&projection&morphogenesis

24 0.31 1.32E>04 PRKCA,&EGFR,&RTN4RL1,&PLA2G10,&GDF7,&BAIAP2,&MAP1B,&DSCAML1,&EPHB3,&GAS7,&CTNNA2,&EPHB2,&SEMA5A,&ALCAM,&SEMA6A,&PTK2,&HOXA2,&NDEL1,&MACF1,&ANK3,&RELN,&VCAN,&MYH10,&FEZ1

2.44

GOTERM_BP_FATGO:0031175~neuron&projection&development

27 0.35 1.36E>04 RTN4RL1,&GDF7,&DSCAML1,&EPHB3,&SCARF1,&EPHB2,&ALCAM,&SEMA5A,&PTK2,&HOXA2,&CD44,&MACF1,&ANK3,&PRKCA,&EGFR,&PLA2G10,&BAIAP2,&MAP1B,&GAS7,&CTNNA2,&SEMA6A,&NDEL1,&RASGRF1,&VCAN,&RELN,&FEZ1,&MYH10

2.28

GOTERM_BP_FATGO:0001501~skeletal&system&development

31 0.40 1.72E>04 FGF18,&PDLIM7,&PRRX1,&DSCAML1,&ZBTB16,&SUFU,&HOXA2,&CHD7,&HOXA3,&HOXA6,&HOXC4,&CHST11,&HOXA9,&PKD1,&AXIN2,&RUNX2,&PRKCA,&EGFR,&TGFBR2,&HSPG2,&ANXA2,&HOXB3,&HDAC4,&PDGFRA,&GDF10,&PBX1,&KIAA1217,&COL1A1,&ATP6V0A4,&EXT1,&BMPR1A

2.10

GOTERM_BP_FATGO:0006928~cell&motion 41 0.53 1.73E>04 GDF7,&CALD1,&CX3CL1,&DNAH7,&EPHB3,&CAPZB,&TPM4,&SRC,&EPHB2,&VCL,&SEMA5A,&ALCAM,&HOXA2,&PTK2,&NDE1,&MACF1,&GAB2,&CD44,&ANK3,&NR2F2,&PPAP2B,&FGF2,&PRKCA,&PLAT,&PLA2G10,&ITGA2,&COL5A1,&CTNNA2,&LSP1,&NCK2,&SEMA6A,&NDEL1,&TNS1,&FYN,&ETS1,&ITGA5,&TGFBR3,&RELN,&VCAN,&MYH10,&FEZ1

1.87

GOTERM_CC_FATGO:0031252~cell&leading&edge 18 0.23 1.90E>04 NF2,&PDLIM7,&TLN2,&BAIAP2,&NEDD9,&CDK6,&MYO9B,&SLC9A3R1,&ADORA1,&CAPZB,&GAS7,&CTNNA3,&CTNNA2,&AKT1,&PTK2,&CTTN,&NDEL1,&ITGA5

2.84

GOTERM_BP_FATGO:0048706~embryonic&skeletal&system&development

13 0.17 1.96E>04 TGFBR2,&HSPG2,&PRRX1,&DSCAML1,&HOXB3,&HOXA2,&HOXA3,&HOXA6,&CHST11,&HOXA9,&KIAA1217,&PBX1,&COL1A1

3.65

GOTERM_CC_FATGO:0044459~plasma&membrane&part 135 1.73 2.15E>04 UTRN,&LPAR3,&ADORA1,&SLC7A6,&VCL,&ATP2B2,&SHB,&ATP2B4,&DYSF,&CD44,&ANK3,&STK39,&FRS2,&EGFR,&F10,&PTPRN2,&EFNB2,&TANC1,&PTPRU,&GEM,&CTNNA3,&CTNNA2,&TNS1,&CD36,&PDGFRA,&ROR1,&PMP22,&SLC40A1,&TNFAIP1,&FRAS1,&CLCN3,&PANX1,&ENPP1,&LITAF,&ENPP3,&NEDD9,&ITGB5,&EPHB3,&SRC,&EPHB2,&PRR7,&ALCAM,&EPHB6,&PTK2,&MUSK,&MACF1,&SCN9A,&PHACTR1,&RAB8A,&LPP,&TGFBR2,&CNKSR3,&ITGA2,&RAB7L1,&SHANK2,&ABCB4,&EPS15,&NTRK3,&ITGA9,&KCTD10,&CASS4,&P2RX6,&FREM2,&RAPSN,&ITGA5,&CD59,&SLC7A1,&NOTCH4,&CD58,&TGFBR3,&RHEB,&KCTD16,&IL5RA,&MTOR,&PDZD2,&SLC9A1,&CD8A,&GRIP1,&TLN2,&SLC15A2,&FERMT2,&SORL1,&CRCP,&KCNJ14,&CCRL2,&CD96,&SMAP1,&ATP8B1,&SV2B,&SV2A,&TRPV6,&ADCY10,&DLG2,&DPP4,&PARVG,&KCNMA1,&CTBP2,&SLC9A3R1,&FMN1,&GRM8,&STXBP5,&IGF2R,&GRM7,&PRKCZ,&CD244,&SHROOM3,&RTN4RL1,&TNFRSF25,&GNG12,&CDH5,&COL17A1,&RAB43,&PEX19,&SORBS1,&HRH2,&PKD1,&RASA3,&AFAP1,&TES,&SYNPO,&IL2RA,&NF2,&SLC12A4,&NPR1,&SLC16A3,&LSP1,&CADPS,&ADCY9,&SVIL,&SLC6A6,&ABCC1,&LRP2,&ATP6V0A4,&ABCC6,&BMPR1A

1.33

GOTERM_BP_FATGO:0007409~axonogenesis 22 0.28 2.29E>04 PRKCA,&RTN4RL1,&PLA2G10,&GDF7,&BAIAP2,&MAP1B,&DSCAML1,&EPHB3,&CTNNA2,&EPHB2,&SEMA5A,&ALCAM,&SEMA6A,&PTK2,&HOXA2,&NDEL1,&MACF1,&ANK3,&RELN,&VCAN,&MYH10,&FEZ1

2.47

GOTERM_BP_FATGO:0048667~cell&morphogenesis&involved&in&neuron&differentiation

23 0.29 2.64E>04 PRKCA,&RTN4RL1,&PLA2G10,&GDF7,&BAIAP2,&MAP1B,&DSCAML1,&EPHB3,&CTNNA2,&EPHB2,&SEMA5A,&ALCAM,&ATP2B2,&SEMA6A,&PTK2,&HOXA2,&NDEL1,&MACF1,&ANK3,&RELN,&VCAN,&MYH10,&FEZ1

2.38

GOTERM_BP_FATGO:0031328~positive&regulation&of&cellular&biosynthetic&process

53 0.68 2.68E>04 FOXK1,&GDF7,&GRIP1,&GDF6,&CTCF,&RORA,&ZBTB38,&AKT1,&MYOCD,&GATA5,&GATA6,&SMARCD3,&TICAM1,&NR2F2,&FAM129A,&FGF2,&MYST4,&PSMD9,&EGFR,&CIITA,&ARID1B,&MECOM,&IL21,&PDGFRA,&SMARCA2,&CSF2,&GLIS3,&GLIS1,&NFYB,&PRDM16,&PLAGL1,&HOXA2,&NPAS2,&MEIS2,&SORBS1,&RUNX2,&ARHGEF10L,&ZNF423,&SOAT1,&KLF12,&MAML2,&TEAD1,&ITGA2,&NPR1,&CREB5,&ATXN7L3,&ATXN1,&HDAC4,&SALL4,&ETS1,&NOTCH4,&PBX1,&MTOR

1.67

GOTERM_BP_FATGO:0010557~positive&regulation&of&macromolecule&biosynthetic&process

51 0.65 2.99E>04 FOXK1,&GDF7,&GRIP1,&GDF6,&CTCF,&RORA,&ZBTB38,&AKT1,&MYOCD,&GATA5,&GATA6,&SMARCD3,&TICAM1,&FAM129A,&NR2F2,&FGF2,&MYST4,&PSMD9,&CIITA,&ARID1B,&MECOM,&IL21,&PDGFRA,&SMARCA2,&CSF2,&GLIS3,&GLIS1,&NFYB,&PRDM16,&PLAGL1,&HOXA2,&NPAS2,&MEIS2,&SORBS1,&RUNX2,&ARHGEF10L,&ZNF423,&SOAT1,&KLF12,&MAML2,&TEAD1,&ITGA2,&CREB5,&ATXN7L3,&ATXN1,&HDAC4,&SALL4,&ETS1,&NOTCH4,&PBX1,&MTOR

1.69

GOTERM_MF_FATGO:0005509~calcium&ion&binding 68 0.87 3.10E>04 ARSB,&PDP1,&PXDN,&LTBP2,&ARSG,&UTRN,&MAN1B1,&TPD52,&ATP2B2,&CDH20,&HMCN1,&ATP2B4,&ANO3,&ANO2,&ANO4,&TRPV6,&ANO6,&KCNMA1,&PRKCA,&F10,&RXFP1,&SCUBE2,&SPARCL1,&GALNTL2,&PADI3,&GALNTL1,&GPR98,&PRKCB,&PITPNM2,&EML1,&GRM7,&VCAN,&RELN,&PROS1,&GALNT9,&FRAS1,&GALNT2,&EFCAB8,&NKD1,&NKD2,&SPOCK2,&CDH5,&TPM4,&SMOC2,&GALNT10,&MACF1,&GALNS,&PLCH1,&PKD2,&HEG1,&FBN2,&THBS2,&PLA2G10,&MRC2,&TRPC7,&ITGA2,&CACNA2D3,&ANXA2,&PXDNL,&CADPS,&EPS15,&ITGA9,&FBLN1,&FREM2,&ITGA5,&SVIL,&NOTCH4,&LRP2

1.55

GOTERM_BP_FATGO:0030029~actin&filament>based&process

25 0.32 3.26E>04 PRKCZ,&SHROOM3,&PDLIM7,&CALD1,&FERMT2,&SSH2,&NEDD9,&MYO9B,&DAAM1,&DAAM2,&CAPZB,&PFN4,&SORBS1,&WIPF1,&FMNL2,&TNXB,&NF2,&FLNB,&GAS7,&EPB41L2,&FMN1,&NCK2,&CAPN10,&ABL1,&MYH10

2.25

GOTERM_BP_FATGO:0032990~cell&part&morphogenesis 26 0.33 3.33E>04 RTN4RL1,&GDF7,&DSCAML1,&EPHB3,&EPHB2,&ALCAM,&SEMA5A,&PTK2,&HOXA2,&MACF1,&ANK3,&PRKCA,&EGFR,&RAB8A,&OPA1,&PLA2G10,&BAIAP2,&MAP1B,&GAS7,&CTNNA2,&SEMA6A,&NDEL1,&VCAN,&RELN,&FEZ1,&MYH10

2.20

GOTERM_CC_FATGO:0005924~cell>substrate&adherens&junction

15 0.19 3.34E>04 PARVG,&TLN2,&LPP,&FERMT2,&NEDD9,&ITGA2,&VCL,&PTK2,&TNS1,&CASS4,&SORBS1,&CD44,&ITGA5,&AFAP1,&TES

3.08

GOTERM_CC_FATGO:0070161~anchoring&junction 20 0.26 3.41E>04 PARVG,&SHROOM3,&NF2,&TLN2,&LPP,&FERMT2,&NEDD9,&ITGA2,&CTNNA3,&CTNNA2,&VCL,&FMN1,&PTK2,&CASS4,&TNS1,&SORBS1,&CD44,&ITGA5,&AFAP1,&TES

2.53

GOTERM_CC_FATGO:0005578~proteinaceous&extracellular&matrix

30 0.38 3.66E>04 FRAS1,&ADAMTS17,&LTBP2,&SPOCK2,&ADAMTSL3,&SMOC2,&COL17A1,&HMCN1,&COL27A1,&VWC2,&FBN2,&LOXL1,&DPT,&SPON1,&TNXB,&COL4A1,&SPARCL1,&CRTAP,&CCDC80,&HSPG2,&COL5A1,&ANXA2,&WNT2B,&FBLN1,&NAV2,&FREM2,&THSD4,&RELN,&VCAN,&COL1A1

2.04

GOTERM_BP_FATGO:0009891~positive&regulation&of&biosynthetic&process

53 0.68 3.73E>04 FOXK1,&GDF7,&GRIP1,&GDF6,&CTCF,&RORA,&ZBTB38,&AKT1,&MYOCD,&GATA5,&GATA6,&SMARCD3,&TICAM1,&NR2F2,&FAM129A,&FGF2,&MYST4,&PSMD9,&EGFR,&CIITA,&ARID1B,&MECOM,&IL21,&PDGFRA,&SMARCA2,&CSF2,&GLIS3,&GLIS1,&NFYB,&PRDM16,&PLAGL1,&HOXA2,&NPAS2,&MEIS2,&SORBS1,&RUNX2,&ARHGEF10L,&ZNF423,&SOAT1,&KLF12,&MAML2,&TEAD1,&ITGA2,&NPR1,&CREB5,&ATXN7L3,&ATXN1,&HDAC4,&SALL4,&ETS1,&NOTCH4,&PBX1,&MTOR

1.65

GOTERM_BP_FATGO:0000904~cell&morphogenesis&involved&in&differentiation

25 0.32 3.91E>04 RTN4RL1,&GDF7,&DSCAML1,&EPHB3,&EPHB2,&ALCAM,&SEMA5A,&ATP2B2,&HOXA2,&PTK2,&MACF1,&ANK3,&PRKCA,&PLA2G10,&BAIAP2,&MAP1B,&CTNNA2,&SEMA6A,&NDEL1,&NOTCH4,&TGFBR3,&VCAN,&RELN,&FEZ1,&MYH10

2.22

GOTERM_BP_FATGO:0048858~cell&projection&morphogenesis

25 0.32 4.15E>04 RTN4RL1,&GDF7,&DSCAML1,&EPHB3,&EPHB2,&ALCAM,&SEMA5A,&PTK2,&HOXA2,&MACF1,&ANK3,&PRKCA,&EGFR,&RAB8A,&PLA2G10,&BAIAP2,&MAP1B,&GAS7,&CTNNA2,&SEMA6A,&NDEL1,&VCAN,&RELN,&FEZ1,&MYH10

2.21

GOTERM_MF_FATGO:0019838~growth&factor&binding 15 0.19 4.56E>04 COL4A1,&IL2RA,&LTBP2,&IGFBP7,&TGFBR2,&ESM1,&COL5A1,&NTRK3,&WISP1,&CD36,&IGF2R,&PDGFRA,&TGFBR3,&IL5RA,&COL1A1

2.99

GOTERM_MF_FATGO:0004697~protein&kinase&C&activity 6 0.08 4.92E>04 PRKCA,&PRKCZ,&PKN2,&PRKCH,&PRKCE,&PRKCB 8.36GOTERM_BP_FATGO:0007010~cytoskeleton&

organization37 0.47 5.22E>04 ABLIM1,&PRKCZ,&SHROOM3,&PDLIM7,&TLN2,&CALD1,&SSH2,&FERMT2,&NEDD9,&

MYO9B,&ANLN,&DAAM1,&DAAM2,&CAPZB,&PTK2,&NDE1,&MACF1,&PFN4,&SORBS1,&ANK3,&WIPF1,&FMNL2,&TNXB,&NF2,&MAP1B,&FLNB,&GAS7,&TACC2,&FMN1,&EPB41L2,&NCK2,&SEMA6A,&NDEL1,&CAPN10,&SVIL,&ABL1,&MYH10

1.84

GOTERM_BP_FATGO:0051216~cartilage&development 12 0.15 5.45E>04 PRKCA,&HOXB3,&FGF18,&HOXA3,&HOXC4,&CHST11,&PRRX1,&HSPG2,&PKD1,&COL1A1,&RUNX2,&BMPR1A

3.51

GOTERM_CC_FATGO:0031012~extracellular&matrix 31 0.40 5.83E>04 FRAS1,&ADAMTS17,&LTBP2,&SPOCK2,&ADAMTSL3,&SMOC2,&COL17A1,&HMCN1,&CD44,&COL27A1,&VWC2,&FBN2,&LOXL1,&DPT,&SPON1,&TNXB,&COL4A1,&SPARCL1,&CRTAP,&CCDC80,&HSPG2,&COL5A1,&ANXA2,&WNT2B,&FBLN1,&NAV2,&FREM2,&THSD4,&RELN,&VCAN,&COL1A1

1.96

GOTERM_BP_FATGO:0050982~detection&of&mechanical&stimulus

6 0.08 5.87E>04 ATP2B2,&FYN,&PKD2,&ITGA2,&PKD1,&GPR98 8.12

GOTERM_BP_FATGO:0007169~transmembrane&receptor&protein&tyrosine&kinase&signaling&pathway

23 0.29 6.87E>04 PLAT,&EGFR,&FGF18,&CD8A,&NIN,&BAIAP2,&EPHB3,&SRC,&EPHB2,&AKT1,&NTRK3,&EPS15,&NCK2,&MUSK,&EPHB6,&PTK2,&SORBS1,&DGKD,&ARF4,&PDGFRA,&ROR1,&FGF2,&FRS2

2.22

GOTERM_BP_FATGO:0043009~chordate&embryonic&development

30 0.38 7.06E>04 SHROOM3,&PRRX1,&DSCAML1,&RGMA,&HOXA2,&CHD7,&HOXA3,&GATA6,&HOXA6,&CHST11,&PKD2,&HOXA9,&PKD1,&AXIN2,&TGFBR2,&HSPG2,&MBNL1,&MECOM,&ZNF358,&HOXB3,&ASCL2,&NDEL1,&SALL4,&SFRP1,&PDGFRA,&TGFBR3,&PBX1,&KIAA1217,&COL1A1,&MYH10

1.96

GOTERM_CC_FATGO:0005925~focal&adhesion 14 0.18 7.61E>04 PARVG,&LPP,&TLN2,&FERMT2,&NEDD9,&ITGA2,&VCL,&PTK2,&TNS1,&CASS4,&CD44,&ITGA5,&AFAP1,&TES

2.99

GOTERM_BP_FATGO:0009792~embryonic&development&ending&in&birth&or&egg&hatching

30 0.38 8.15E>04 SHROOM3,&PRRX1,&DSCAML1,&RGMA,&HOXA2,&CHD7,&HOXA3,&GATA6,&HOXA6,&CHST11,&PKD2,&HOXA9,&PKD1,&AXIN2,&TGFBR2,&HSPG2,&MBNL1,&MECOM,&ZNF358,&HOXB3,&ASCL2,&NDEL1,&SALL4,&SFRP1,&PDGFRA,&TGFBR3,&PBX1,&KIAA1217,&COL1A1,&MYH10

1.94

GOTERM_BP_FATGO:0000271~polysaccharide&biosynthetic&process

9 0.12 9.30E>04 CSGALNACT1,&AKT1,&GCNT2,&GBE1,&GLT25D2,&SLC35D1,&CHST11,&MAT2B,&EXT1 4.33

GOTERM_MF_FATGO:0030695~GTPase&regulator&activity

35 0.45 9.61E>04 IQGAP2,&MYO9B,&ARHGAP15,&ARHGAP12,&GARNL3,&SMAP1,&PLEKHG1,&RGS12,&TBC1D14,&GIT2,&TBC1D5,&RAPGEF5,&RAPGEF4,&RAP1GAP2,&RASA3,&ARHGEF10L,&SERGEF,&NGEF,&TBC1D2B,&DAB2IP,&ABR,&DOCK9,&HERC1,&DOCK5,&ARHGEF10,&DOCK4,&ANXA2,&MAP4K3,&RGS3,&RASGRF1,&RGS5,&RIN2,&SYTL3,&ARAP2,&BCAR3

1.81

GOTERM_BP_FATGO:0009612~response&to&mechanical&stimulus

10 0.13 9.68E>04 PRKCA,&ATP2B2,&FYN,&MAP1B,&TGFBR2,&PKD2,&ITGA2,&PKD1,&COL1A1,&GPR98 3.87

GOTERM_BP_FATGO:0048666~neuron&development 30 0.38 1.03E>03 RTN4RL1,&GDF7,&DSCAML1,&EPHB3,&SCARF1,&EPHB2,&ALCAM,&SEMA5A,&ATP2B2,&PTK2,&HOXA2,&MACF1,&CD44,&ANK3,&PRKCA,&EGFR,&PLA2G10,&BAIAP2,&MAP1B,&GAS7,&GPR98,&CTNNA2,&SEMA6A,&NDEL1,&RASGRF1,&VCAN,&RELN,&NTM,&MYH10,&FEZ1

1.92

GOTERM_BP_FATGO:0000902~cell&morphogenesis 31 0.40 1.08E>03 SHROOM3,&RTN4RL1,&GDF7,&BRSK2,&DSCAML1,&EPHB3,&EPHB2,&SEMA5A,&ALCAM,&ATP2B2,&NDE1,&PTK2,&HOXA2,&MACF1,&ANK3,&PRKCA,&EGFR,&RAB8A,&PLA2G10,&BAIAP2,&MAP1B,&GAS7,&CTNNA2,&SEMA6A,&NDEL1,&NOTCH4,&TGFBR3,&VCAN,&RELN,&MYH10,&FEZ1

1.88

GOTERM_BP_FATGO:0030182~neuron&differentiation 36 0.46 1.11E>03 RTN4RL1,&GDF7,&BRSK2,&DSCAML1,&RORA,&EPHB3,&SCARF1,&EPHB2,&SEMA5A,&ALCAM,&ATP2B2,&PTK2,&HOXA2,&MACF1,&CD44,&ANK3,&PRKCA,&EGFR,&KCNMA1,&DFNA5,&PLA2G10,&BAIAP2,&MAP1B,&GAS7,&GPR98,&CTNNA2,&NTRK3,&SEMA6A,&NDEL1,&RASGRF1,&RELN,&VCAN,&CUX1,&NTM,&MYH10,&FEZ1

1.78

GOTERM_CC_FATGO:0005886~plasma&membrane 208 2.67 1.19E>03 FHIT,&UTRN,&LPAR3,&ADORA1,&ATP2B2,&SHB,&CDH20,&PSKH1,&ATP2B4,&CD44,&F10,&EFNB2,&TANC1,&GEM,&PTPRU,&CTNNA3,&CTNNA2,&CD36,&PDGFRA,&ROR1,&TFPI,&PMP22,&CLCN3,&ENPP1,&ENPP3,&EPHB3,&EPHB2,&SEMA5A,&ALCAM,&EPHB6,&MUSK,&MACF1,&EPM2A,&TGFBR2,&CNKSR3,&RAB7L1,&NTRK3,&RGS3,&RAPSN,&CD59,&ARF4,&CD58,&NOTCH4,&RHEB,&TGFBR3,&GRK5,&IL5RA,&SMURF1,&SLC9A1,&TM7SF4,&GRIP1,&SLC15A2,&FERMT2,&CRCP,&KCNJ14,&ART4,&SMAP1,&TRPV6,&ADCY10,&DPP4,&KCNMA1,&PARVG,&CTBP2,&RXFP1,&PIK3C2B,&FLNC,&GPR98,&FMN1,&EPB41L2,&GRM8,&CLIC4,&GRM7,&ADAM12,&NKD1,&SHROOM3,&NKD2,&GNG12,&ZBTB16,&NETO1,&RAB43,&PEX19,&SORBS1,&DGKD,&PKD2,&PKD1,&RASA3,&AFAP1,&HSD17B7,&HSD17B8,&TES,&LMNA,&NPR1,&SLC16A3,&LSP1,&ADCY9,&FYN,&SVIL,&ABCC4,&ABCC1,&LRP2,&ATP6V0A4,&ABCC6,&CTNNAL1,&PLXNA4,&SLC7A6,&VCL,&DYSF,&ANK3,&DNAJC5,&STK39,&GLP2R,&FRS2,&EGFR,&BAIAP2,&PTPRN2,&CA12,&MRGPRF,&LAT2,&TNS1,&RASGRF1,&COL1A1,&SLC40A1,&TNFAIP1,&FRAS1,&HDLBP,&PANX1,&LITAF,&ITGB5,&NEDD9,&CNTFR,&CX3CL1,&SRC,&PRR7,&PTK2,&SCN9A,&PHACTR1,&RAB8A,&LPP,&ITGA2,&SHANK2,&ABCB4,&EPS15,&ITGA9,&KCTD10,&OR51S1,&CASS4,&P2RX6,&FREM2,&ITGA5,&SLC7A1,&ANTXR2,&KCTD16,&MTOR,&PDZD2,&MYH10,&CD8A,&TLN2,&SORL1,&LGR4,&AKT1,&CCRL2,&SPRY2,&CD96,&CXCR7,&ATP8B1,&SV2B,&SV2A,&NRG2,&DLG2,&PRKCA,&ATP6V1H,&PRKCH,&SLC9A3R1,&PRKCE,&PRKCB,&CAPN10,&STXBP5,&IGF2R,&SLC41A1,&KIAA0513,&JAM3,&EPN1,&PMEPA1,&PRKCZ,&CD244,&RTN4RL1,&TNFRSF25,&CALD1,&GPRC5B,&CDH5,&RGMA,&COL17A1,&HRH2,&PPAP2B,&SYNPO,&NGEF,&PTPRE,&IL2RA,&NF2,&SLC12A4,&MAP1B,&IGSF9B,&ANXA2,&CADPS,&SLC6A6,&NTM,&FEZ1,&BMPR1A

1.20

GOTERM_MF_FATGO:0004714~transmembrane&receptor&protein&tyrosine&kinase&activity

11 0.14 1.21E>03 EGFR,&NTRK3,&MUSK,&EPHB6,&NIN,&IGF2R,&PDGFRL,&PDGFRA,&ROR1,&EPHB3,&EPHB2 3.43

GOTERM_BP_FATGO:0001944~vasculature&development

24 0.31 1.35E>03 PLAT,&FGF18,&EFNB2,&TGFBR2,&PRRX1,&COL5A1,&CDH5,&ANXA2,&SEMA5A,&AKT1,&SHB,&PTK2,&HOXA3,&CHD7,&CD44,&MYOCD,&PLXDC1,&NOTCH4,&PKD1,&TGFBR3,&COL1A1,&NR2F2,&FGF2,&PPAP2B

2.07

GOTERM_MF_FATGO:0060589~nucleoside>triphosphatase&regulator&activity

35 0.45 1.40E>03 IQGAP2,&MYO9B,&ARHGAP15,&ARHGAP12,&GARNL3,&SMAP1,&PLEKHG1,&RGS12,&TBC1D14,&GIT2,&TBC1D5,&RAPGEF5,&RAPGEF4,&RAP1GAP2,&RASA3,&ARHGEF10L,&SERGEF,&NGEF,&TBC1D2B,&DAB2IP,&ABR,&DOCK9,&HERC1,&DOCK5,&ARHGEF10,&DOCK4,&ANXA2,&MAP4K3,&RGS3,&RASGRF1,&RGS5,&RIN2,&SYTL3,&ARAP2,&BCAR3

1.77

GOTERM_BP_FATGO:0043062~extracellular&structure&organization

18 0.23 1.41E>03 DNM3,&TNXB,&RXFP1,&SPOCK2,&UTRN,&MAP1B,&HSPG2,&CCDC80,&COL5A1,&ANXA2,&CSGALNACT1,&ATP2B2,&PTK2,&MUSK,&ANK3,&PDGFRA,&COL1A1,&DPT

2.39

GOTERM_CC_FATGO:0044421~extracellular&region&part 65 0.83 1.45E>03 PNLIP,&FGF18,&LTBP2,&GDF7,&GDF6,&IGFBP7,&SORL1,&HMCN1,&CD44,&SEMA3E,&LOXL3,&LOXL2,&LOXL1,&FGF2,&SPON1,&EGFR,&SPARCL1,&CRTAP,&ADNP,&IL21,&NAV2,&TFPI,&VCAN,&RELN,&COL1A1,&FRAS1,&TG,&CSF2,&ADAMTS17,&HDLBP,&ENPP1,&ADAMTSL3,&SPOCK2,&CX3CL1,&C1QTNF7,&SMOC2,&COL17A1,&COL27A1,&VWC2,&FBN2,&DPT,&PLAT,&PNLIPRP1,&TNXB,&COL4A1,&HSPG2,&CCDC80,&COL5A1,&HPR,&WNT2B,&ANXA2,&AFP,&FBLN1,&SFRP1,&FREM2,&SFRP4,&NOTCH4,&THSD4,&LIPG,&TGFBR3,&GDF10,&IL5RA,&LRP2,&SST,&IL22RA2

1.47

GOTERM_BP_FATGO:0032989~cellular&component&morphogenesis

33 0.42 1.55E>03 SHROOM3,&RTN4RL1,&GDF7,&BRSK2,&DSCAML1,&EPHB3,&EPHB2,&SEMA5A,&ALCAM,&ATP2B2,&NDE1,&PTK2,&HOXA2,&MACF1,&ANK3,&PRKCA,&EGFR,&RAB8A,&OPA1,&PLA2G10,&BAIAP2,&MAP1B,&GAS7,&CTNNA2,&SEMA6A,&NDEL1,&NOTCH4,&TGFBR3,&RELN,&VCAN,&PMP22,&MYH10,&FEZ1

1.80

GOTERM_BP_FATGO:0048705~skeletal&system&morphogenesis

14 0.18 1.93E>03 FGF18,&TGFBR2,&HSPG2,&PRRX1,&DSCAML1,&HOXB3,&HOXA2,&HOXA3,&HOXA6,&CHST11,&PDGFRA,&PKD1,&COL1A1,&RUNX2

2.71

GOTERM_BP_FATGO:0051173~positive&regulation&of&nitrogen&compound&metabolic&process

47 0.60 2.04E>03 CSF2,&GLIS3,&FOXK1,&GDF7,&GRIP1,&GDF6,&GLIS1,&CTCF,&NFYB,&RORA,&PRDM16,&ZBTB38,&PLAGL1,&AKT1,&NPAS2,&HOXA2,&MEIS2,&GATA5,&MYOCD,&GATA6,&SMARCD3,&TICAM1,&NR2F2,&RUNX2,&FGF2,&MYST4,&ARHGEF10L,&ZNF423,&PSMD9,&CIITA,&EGFR,&KLF12,&MAML2,&TEAD1,&NPR1,&CREB5,&ARID1B,&MECOM,&ATXN7L3,&ATXN1,&HDAC4,&SALL4,&ETS1,&NOTCH4,&PDGFRA,&PBX1,&SMARCA2

1.58

GOTERM_BP_FATGO:0010604~positive&regulation&of&macromolecule&metabolic&process

59 0.76 2.12E>03 FOXK1,&GDF7,&GRIP1,&GDF6,&PRKAG2,&CTCF,&RORA,&ADORA1,&ZBTB38,&AKT1,&MYOCD,&GATA5,&SMARCD3,&GATA6,&ATG7,&TICAM1,&NR2F2,&FAM129A,&FGF2,&MYST4,&PSMD9,&PRKCA,&CIITA,&ARID1B,&IL21,&MECOM,&PDGFRA,&ANAPC7,&SMARCA2,&CSF2,&GLIS3,&GLIS1,&NFYB,&PRDM16,&PLAGL1,&NPAS2,&HOXA2,&MEIS2,&SORBS1,&RUNX2,&ARHGEF10L,&ZNF423,&SOAT1,&PLA2G10,&KLF12,&MAML2,&TEAD1,&ITGA2,&CREB5,&ATXN7L3,&ATXN1,&HDAC4,&SALL4,&ETS1,&NOTCH4,&PBX1,&SMURF1,&MTOR,&BMPR1A

1.49

GOTERM_BP_FATGO:0043467~regulation&of&generation&of&precursor&metabolites&and&energy

7 0.09 2.16E>03 AKT1,&HDAC4,&SORBS1,&ENPP1,&PRKAG2,&MTOR,&PRDM16 5.05

GOTERM_BP_FATGO:0001568~blood&vessel&development

23 0.29 2.20E>03 PLAT,&FGF18,&TGFBR2,&PRRX1,&COL5A1,&CDH5,&ANXA2,&SEMA5A,&AKT1,&SHB,&PTK2,&HOXA3,&CHD7,&CD44,&MYOCD,&PLXDC1,&NOTCH4,&PKD1,&TGFBR3,&COL1A1,&NR2F2,&FGF2,&PPAP2B

2.03

GOTERM_MF_FATGO:0001883~purine&nucleoside&binding

101 1.30 2.59E>03 XRCC3,&CTPS,&PKMYT1,&ADORA1,&ATP2B2,&PSKH1,&ATP2B4,&STK39,&RAPGEF4,&EGFR,&CIITA,&CARS,&STK24,&MYLK4,&GEM,&MAP4K3,&NAV2,&PDGFRA,&ROR1,&CAMK1,&ARL8B,&MYO18A,&SMARCA2,&CLCN3,&ENPP1,&MAPKAPK5,&C9ORF98,&MYO9B,&EPHB3,&SRC,&TK2,&EPHB2,&EPHB6,&PTK2,&MUSK,&VRK2,&POLQ,&RUNX2,&NIN,&MYO1B,&TGFBR2,&CNKSR3,&ACACA,&ATP11A,&MTHFSD,&OXSR1,&UBE2L3,&ABCB4,&NTRK3,&MYO10,&P2RX6,&PLK2,&RAD54B,&MTOR,&GRK5,&IKBKB,&ABL1,&PIP4K2A,&ACAD10,&ATAD2B,&PC,&MYH10,&ACOX1,&ZNFX1,&NUAK1,&PRKAG2,&ACOX3,&AKT1,&ATP8B1,&ADCY10,&PRKCA,&PIK3C2B,&PKN2,&PFKP,&PRKCH,&CDK6,&PRKCE,&PRKCB,&TXNRD1,&PRKCZ,&BRSK2,&DNAH7,&DNAH6,&UBE2R2,&GALK2,&CHD7,&DGKD,&SPEG,&FMO2,&DCLK2,&ALPK3,&ALPK2,&NPR1,&ADCY9,&FYN,&ABCC4,&ABCC1,&TSSK1B,&IPPK,&ABCC6,&BMPR1A

1.32

GOTERM_CC_FATGO:0044420~extracellular&matrix&part 14 0.18 2.70E>03 FRAS1,&COL4A1,&TNXB,&HSPG2,&CCDC80,&COL5A1,&ANXA2,&SMOC2,&COL17A1,&HMCN1,&FREM2,&COL27A1,&VWC2,&COL1A1

2.61

GOTERM_MF_FATGO:0004674~protein&serine/threonine&kinase&activity

35 0.45 2.72E>03 PRKCZ,&NUAK1,&MAPKAPK5,&LGMN,&PRKAG2,&BRSK2,&PKMYT1,&AKT1,&PSKH1,&VRK2,&SPEG,&DCLK2,&STK39,&PRKCA,&EGFR,&ALPK3,&STK24,&ALPK2,&MYLK4,&TGFBR2,&PKN2,&PRKCH,&CDK6,&OXSR1,&PRKCE,&PRKCB,&MAP4K3,&PLK2,&CAMK1,&TGFBR3,&TSSK1B,&MTOR,&GRK5,&IKBKB,&BMPR1A

1.70

GOTERM_BP_FATGO:0048736~appendage&development

13 0.17 2.75E>03 PRRX1,&ZBTB16,&MBNL1,&MECOM,&ZNF358,&CHD7,&SALL4,&CHST11,&HOXA9,&PBX1,&FBN2,&NR2F2,&BMPR1A

2.73

GOTERM_BP_FATGO:0060173~limb&development 13 0.17 2.75E>03 PRRX1,&ZBTB16,&MBNL1,&MECOM,&ZNF358,&CHD7,&SALL4,&CHST11,&HOXA9,&PBX1,&FBN2,&NR2F2,&BMPR1A

2.73

GOTERM_CC_FATGO:0009898~internal&side&of&plasma&membrane

27 0.35 2.87E>03 LITAF,&TLN2,&UTRN,&CRCP,&GNG12,&VCL,&SHB,&PTK2,&SMAP1,&RAB43,&PEX19,&ADCY10,&RASA3,&PARVG,&RAB8A,&NF2,&GEM,&RAB7L1,&CTNNA2,&LSP1,&EPS15,&FMN1,&CADPS,&RAPSN,&SVIL,&RHEB,&MTOR

1.86

GOTERM_CC_FATGO:0005604~basement&membrane 11 0.14 2.88E>03 FRAS1,&SMOC2,&COL17A1,&HMCN1,&COL4A1,&FREM2,&CCDC80,&HSPG2,&VWC2,&COL5A1,&ANXA2

3.07

GOTERM_MF_FATGO:0008376~acetylgalactosaminyltransferase&activity

7 0.09 3.06E>03 CSGALNACT1,&GALNT2,&GALNT10,&GALNTL2,&CHSY1,&GALNTL1,&GALNT9 4.72

GOTERM_BP_FATGO:0051056~regulation&of&small&GTPase&mediated&signal&transduction

23 0.29 3.11E>03 NGEF,&TBC1D2B,&DAB2IP,&ABR,&IQGAP2,&ARHGEF10,&GARNL3,&PLEKHG1,&SMAP1,&NDEL1,&RASGRF1,&TBC1D14,&PPP2CB,&GIT2,&TBC1D5,&RAPGEF5,&RAPGEF4,&RELN,&MTOR,&RASA3,&RAP1GAP2,&ARAP2,&ARHGEF10L

1.98

GOTERM_CC_FATGO:0016324~apical&plasma&membrane

15 0.19 3.12E>03 KCNMA1,&EGFR,&CLCN3,&SHROOM3,&SLC9A3R1,&ABCB4,&ATP2B2,&PTK2,&CD44,&ATP8B1,&STK39,&ATP6V0A4,&LRP2,&DPP4,&ABCC6

2.46

GOTERM_MF_FATGO:0001882~nucleoside&binding 101 1.30 3.25E>03 XRCC3,&CTPS,&PKMYT1,&ADORA1,&ATP2B2,&PSKH1,&ATP2B4,&STK39,&RAPGEF4,&EGFR,&CIITA,&CARS,&STK24,&MYLK4,&GEM,&MAP4K3,&NAV2,&PDGFRA,&ROR1,&CAMK1,&ARL8B,&MYO18A,&SMARCA2,&CLCN3,&ENPP1,&MAPKAPK5,&C9ORF98,&MYO9B,&EPHB3,&SRC,&TK2,&EPHB2,&EPHB6,&PTK2,&MUSK,&VRK2,&POLQ,&RUNX2,&NIN,&MYO1B,&TGFBR2,&CNKSR3,&ACACA,&ATP11A,&MTHFSD,&OXSR1,&UBE2L3,&ABCB4,&NTRK3,&MYO10,&P2RX6,&PLK2,&RAD54B,&MTOR,&GRK5,&IKBKB,&ABL1,&PIP4K2A,&ACAD10,&ATAD2B,&PC,&MYH10,&ACOX1,&ZNFX1,&NUAK1,&PRKAG2,&ACOX3,&AKT1,&ATP8B1,&ADCY10,&PRKCA,&PIK3C2B,&PKN2,&PFKP,&PRKCH,&CDK6,&PRKCE,&PRKCB,&TXNRD1,&PRKCZ,&BRSK2,&DNAH7,&DNAH6,&UBE2R2,&GALK2,&CHD7,&DGKD,&SPEG,&FMO2,&DCLK2,&ALPK3,&ALPK2,&NPR1,&ADCY9,&FYN,&ABCC4,&ABCC1,&TSSK1B,&IPPK,&ABCC6,&BMPR1A

1.31

GOTERM_CC_FATGO:0001726~ruffle 10 0.13 3.34E>03 CTTN,&NF2,&PDLIM7,&TLN2,&ITGA5,&BAIAP2,&CDK6,&MYO9B,&SLC9A3R1,&GAS7 3.25GOTERM_CC_FATGO:0045177~apical&part&of&cell 18 0.23 3.56E>03 PLAT,&EGFR,&KCNMA1,&PRKCZ,&CLCN3,&SHROOM3,&LGMN,&SLC9A3R1,&ABCB4,&

ATP2B2,&PTK2,&CD44,&ATP8B1,&STK39,&LRP2,&ATP6V0A4,&DPP4,&ABCC62.19

GOTERM_BP_FATGO:0046324~regulation&of&glucose&import

7 0.09 3.59E>03 PRKCA,&AKT1,&PRKCZ,&CAPN10,&SORBS1,&ENPP1,&PRKAG2 4.59

GOTERM_CC_FATGO:0045202~synapse 29 0.37 3.68E>03 TLN2,&GRIP1,&CALD1,&UTRN,&ADORA1,&PRR7,&MUSK,&ANK3,&SV2B,&SV2A,&DLG2,&SYNPO,&PLAT,&KCNMA1,&DNM3,&PHACTR1,&CTBP2,&SPARCL1,&MAP1B,&TANC1,&SHANK2,&CADPS,&P2RX6,&GRM8,&RAPSN,&STXBP5,&GRM7,&SLC40A1,&MYH10

1.78

GOTERM_BP_FATGO:0016051~carbohydrate&biosynthetic&process

13 0.17 3.77E>03 GCNT2,&B3GALT2,&FBP2,&AKT1,&CSGALNACT1,&GBE1,&GLT25D2,&SLC35D1,&CHST11,&MAT2B,&EXT1,&UGP2,&PC

2.63

GOTERM_BP_FATGO:0021955~central&nervous&system&neuron&axonogenesis

5 0.06 4.07E>03 PRKCA,&PTK2,&NDEL1,&EPHB3,&EPHB2 7.21

GOTERM_BP_FATGO:0010827~regulation&of&glucose&transport

7 0.09 4.19E>03 PRKCA,&AKT1,&PRKCZ,&CAPN10,&SORBS1,&ENPP1,&PRKAG2 4.46

GOTERM_MF_FATGO:0005096~GTPase&activator&activity 21 0.27 4.36E>03 TBC1D2B,&DAB2IP,&ABR,&IQGAP2,&MYO9B,&ARHGAP15,&DOCK4,&ARHGAP12,&GARNL3,&SMAP1,&RGS12,&RGS3,&TBC1D14,&RGS5,&GIT2,&RIN2,&TBC1D5,&RASA3,&RAP1GAP2,&ARAP2,&ARHGEF10L

2.00

GOTERM_BP_FATGO:0010628~positive&regulation&of&gene&expression

42 0.54 4.39E>03 CSF2,&GLIS3,&FOXK1,&GDF7,&GRIP1,&GDF6,&GLIS1,&CTCF,&NFYB,&RORA,&PRDM16,&ZBTB38,&PLAGL1,&NPAS2,&HOXA2,&MEIS2,&GATA5,&MYOCD,&GATA6,&SMARCD3,&NR2F2,&FGF2,&RUNX2,&MYST4,&ARHGEF10L,&ZNF423,&PSMD9,&CIITA,&KLF12,&MAML2,&TEAD1,&CREB5,&ARID1B,&MECOM,&ATXN7L3,&ATXN1,&HDAC4,&SALL4,&ETS1,&NOTCH4,&PBX1,&SMARCA2

1.56

GOTERM_BP_FATGO:0048704~embryonic&skeletal&system&morphogenesis

9 0.12 4.39E>03 HOXB3,&HOXA2,&HOXA3,&HOXA6,&CHST11,&TGFBR2,&PRRX1,&HSPG2,&DSCAML1 3.42

GOTERM_BP_FATGO:0045597~positive&regulation&of&cell&differentiation

21 0.27 4.63E>03 CSF2,&IL2RA,&PDLIM7,&PLA2G10,&TGFBR2,&MAP1B,&IL21,&EPHB2,&AKT1,&NTRK3,&SMAP1,&CD36,&NDEL1,&GATA6,&ETS1,&VWC2,&CAMK1,&FGF2,&RUNX2,&FNDC3B,&BMPR1A

1.98

GOTERM_BP_FATGO:0045941~positive&regulation&of&transcription

41 0.53 4.64E>03 GLIS3,&FOXK1,&GDF7,&GRIP1,&GDF6,&GLIS1,&CTCF,&NFYB,&RORA,&PRDM16,&ZBTB38,&PLAGL1,&NPAS2,&HOXA2,&MEIS2,&GATA5,&MYOCD,&GATA6,&SMARCD3,&NR2F2,&FGF2,&RUNX2,&MYST4,&ARHGEF10L,&ZNF423,&PSMD9,&CIITA,&KLF12,&MAML2,&TEAD1,&CREB5,&ARID1B,&MECOM,&ATXN7L3,&ATXN1,&HDAC4,&SALL4,&ETS1,&NOTCH4,&PBX1,&SMARCA2

1.57

GOTERM_MF_FATGO:0030554~adenyl&nucleotide&binding

98 1.26 4.68E>03 XRCC3,&CTPS,&PKMYT1,&ATP2B2,&PSKH1,&ATP2B4,&STK39,&RAPGEF4,&EGFR,&CIITA,&CARS,&STK24,&MYLK4,&MAP4K3,&NAV2,&PDGFRA,&ROR1,&CAMK1,&MYO18A,&SMARCA2,&CLCN3,&ENPP1,&MAPKAPK5,&C9ORF98,&MYO9B,&EPHB3,&SRC,&TK2,&EPHB2,&PTK2,&MUSK,&EPHB6,&VRK2,&POLQ,&RUNX2,&NIN,&MYO1B,&CNKSR3,&TGFBR2,&ACACA,&ATP11A,&MTHFSD,&OXSR1,&UBE2L3,&ABCB4,&NTRK3,&MYO10,&P2RX6,&PLK2,&RAD54B,&MTOR,&GRK5,&IKBKB,&ABL1,&PIP4K2A,&ACAD10,&ATAD2B,&PC,&MYH10,&ACOX1,&ZNFX1,&NUAK1,&PRKAG2,&ACOX3,&AKT1,&ATP8B1,&ADCY10,&PRKCA,&PIK3C2B,&PKN2,&PFKP,&PRKCH,&CDK6,&PRKCE,&PRKCB,&TXNRD1,&PRKCZ,&BRSK2,&DNAH7,&DNAH6,&UBE2R2,&GALK2,&CHD7,&DGKD,&SPEG,&FMO2,&DCLK2,&ALPK3,&ALPK2,&NPR1,&ADCY9,&FYN,&ABCC4,&ABCC1,&TSSK1B,&IPPK,&ABCC6,&BMPR1A

1.30

GOTERM_BP_FATGO:0045935~positive&regulation&of&nucleobase,&nucleoside,&nucleotide&and&nucleic&acid&metabolic&process

44 0.56 5.58E>03 CSF2,&GLIS3,&FOXK1,&GDF7,&GRIP1,&GDF6,&GLIS1,&CTCF,&NFYB,&RORA,&PRDM16,&ZBTB38,&PLAGL1,&NPAS2,&HOXA2,&MEIS2,&GATA5,&MYOCD,&GATA6,&SMARCD3,&NR2F2,&FGF2,&RUNX2,&MYST4,&ARHGEF10L,&ZNF423,&PSMD9,&CIITA,&KLF12,&MAML2,&TEAD1,&NPR1,&CREB5,&ARID1B,&MECOM,&ATXN7L3,&ATXN1,&HDAC4,&SALL4,&ETS1,&NOTCH4,&PDGFRA,&PBX1,&SMARCA2

1.53

GOTERM_BP_FATGO:0035108~limb&morphogenesis 12 0.15 5.83E>03 CHD7,&SALL4,&CHST11,&PRRX1,&HOXA9,&PBX1,&ZBTB16,&MBNL1,&FBN2,&MECOM,&ZNF358,&BMPR1A

2.62

GOTERM_BP_FATGO:0035107~appendage&morphogenesis

12 0.15 5.83E>03 CHD7,&SALL4,&CHST11,&PRRX1,&HOXA9,&PBX1,&ZBTB16,&MBNL1,&FBN2,&MECOM,&ZNF358,&BMPR1A

2.62

GOTERM_MF_FATGO:0004713~protein&tyrosine&kinase&activity

17 0.22 5.89E>03 EGFR,&NIN,&STK24,&NPR1,&EPHB3,&SRC,&EPHB2,&NTRK3,&PTK2,&EPHB6,&MUSK,&FYN,&IGF2R,&PDGFRL,&PDGFRA,&ROR1,&ABL1

2.14

GOTERM_BP_FATGO:0033692~cellular&polysaccharide&biosynthetic&process

6 0.08 6.03E>03 CSGALNACT1,&AKT1,&GBE1,&GLT25D2,&MAT2B,&EXT1 4.99

GOTERM_MF_FATGO:0005524~ATP&binding 92 1.18 6.08E>03 XRCC3,&ZNFX1,&NUAK1,&CTPS,&PRKAG2,&PKMYT1,&AKT1,&ATP2B2,&PSKH1,&ATP2B4,&ATP8B1,&STK39,&ADCY10,&CIITA,&PRKCA,&EGFR,&CARS,&STK24,&PIK3C2B,&MYLK4,&PFKP,&PKN2,&PRKCH,&CDK6,&PRKCE,&PRKCB,&MAP4K3,&NAV2,&ROR1,&PDGFRA,&CAMK1,&SMARCA2,&MYO18A,&PRKCZ,&CLCN3,&ENPP1,&MAPKAPK5,&C9ORF98,&BRSK2,&MYO9B,&DNAH7,&EPHB3,&TK2,&SRC,&UBE2R2,&EPHB2,&DNAH6,&GALK2,&EPHB6,&PTK2,&MUSK,&VRK2,&CHD7,&DGKD,&SPEG,&DCLK2,&POLQ,&RUNX2,&NIN,&ALPK3,&ALPK2,&MYO1B,&CNKSR3,&TGFBR2,&ACACA,&ATP11A,&NPR1,&MTHFSD,&OXSR1,&UBE2L3,&ABCB4,&NTRK3,&MYO10,&P2RX6,&ADCY9,&PLK2,&FYN,&ABCC4,&ABCC1,&RAD54B,&GRK5,&MTOR,&TSSK1B,&IKBKB,&IPPK,&ABL1,&PIP4K2A,&ABCC6,&BMPR1A,&ATAD2B,&MYH10,&PC

1.30

GOTERM_MF_FATGO:0032559~adenyl&ribonucleotide&binding

93 1.19 6.13E>03 XRCC3,&ZNFX1,&NUAK1,&CTPS,&PRKAG2,&PKMYT1,&AKT1,&ATP2B2,&PSKH1,&ATP2B4,&ATP8B1,&RAPGEF4,&STK39,&ADCY10,&CIITA,&PRKCA,&EGFR,&CARS,&STK24,&PIK3C2B,&MYLK4,&PFKP,&PKN2,&PRKCH,&CDK6,&PRKCE,&PRKCB,&MAP4K3,&NAV2,&ROR1,&PDGFRA,&CAMK1,&SMARCA2,&MYO18A,&PRKCZ,&CLCN3,&ENPP1,&MAPKAPK5,&C9ORF98,&BRSK2,&MYO9B,&DNAH7,&EPHB3,&TK2,&SRC,&UBE2R2,&EPHB2,&DNAH6,&GALK2,&EPHB6,&PTK2,&MUSK,&VRK2,&CHD7,&DGKD,&SPEG,&DCLK2,&POLQ,&RUNX2,&NIN,&ALPK3,&ALPK2,&MYO1B,&CNKSR3,&TGFBR2,&ACACA,&ATP11A,&NPR1,&MTHFSD,&OXSR1,&UBE2L3,&ABCB4,&NTRK3,&MYO10,&P2RX6,&ADCY9,&PLK2,&FYN,&ABCC4,&ABCC1,&RAD54B,&GRK5,&MTOR,&TSSK1B,&IKBKB,&IPPK,&ABL1,&PIP4K2A,&ABCC6,&BMPR1A,&ATAD2B,&MYH10,&PC

1.30

GOTERM_MF_FATGO:0005083~small&GTPase&regulator&activity

24 0.31 6.24E>03 SERGEF,&NGEF,&TBC1D2B,&ABR,&DOCK9,&IQGAP2,&MYO9B,&HERC1,&ARHGEF10,&DOCK4,&ANXA2,&MAP4K3,&GARNL3,&PLEKHG1,&SMAP1,&RASGRF1,&TBC1D14,&GIT2,&RIN2,&TBC1D5,&RAPGEF5,&SYTL3,&ARAP2,&ARHGEF10L

1.83

GOTERM_BP_FATGO:0001932~regulation&of&protein&amino&acid&phosphorylation

17 0.22 6.32E>03 PRKCA,&EGFR,&CSF2,&PRKCZ,&ENPP1,&NF2,&GDF7,&GDF6,&PRKAG2,&PRKCE,&RAPGEF4,&PDGFD,&MTOR,&FAM129A,&FGF2,&IL22RA2,&BMPR1A

2.13

GOTERM_CC_FATGO:0005911~cell>cell&junction 18 0.23 6.48E>03 PRKCZ,&SHROOM3,&PANX1,&TLN2,&CNKSR3,&PTPRU,&CTNNA3,&CDH5,&CTNNA2,&ABCB4,&VCL,&COL17A1,&SORBS1,&ITGA5,&PMP22,&PDZD2,&DPP4,&SYNPO

2.06

GOTERM_CC_FATGO:0000267~cell&fraction 68 0.87 6.61E>03 CYB5R2,&SLC15A2,&UTRN,&MAN1B1,&PKMYT1,&AKT1,&ATP2B2,&CTTN,&WISP1,&ANK3,&PDE4B,&ATP8B1,&RAPGEF4,&STK39,&LMOD1,&ADCY10,&FRS2,&DPP4,&PRKCA,&F10,&PIK3C2B,&PFKP,&BLMH,&PITPNM2,&CD36,&RASGRF1,&CLIC4,&IGF2R,&PRKCZ,&GCNT3,&GCNT2,&CALD1,&MYO9B,&ACP1,&CDH5,&VRK2,&FMO2,&PLCH1,&PKD1,&HSD17B8,&SOAT1,&MLC1,&SLC12A4,&MAP1B,&LMNA,&ACACA,&CPT1A,&ANXA2,&ABCB4,&SLC16A3,&CSGALNACT1,&FBLN1,&P2RX6,&PDE7A,&ITGA5,&CD59,&ABCC4,&ABCC1,&GRK5,&MTOR,&LRP2,&IKBKB,&CORT,&UGT2B7,&PC,&ABCC6,&MGST2,&SLC9A1

1.37

GOTERM_BP_FATGO:0030326~embryonic&limb&morphogenesis

11 0.14 6.62E>03 CHD7,&SALL4,&CHST11,&PRRX1,&HOXA9,&PBX1,&ZBTB16,&MBNL1,&FBN2,&MECOM,&ZNF358

2.74

GOTERM_BP_FATGO:0035113~embryonic&appendage&morphogenesis

11 0.14 6.62E>03 CHD7,&SALL4,&CHST11,&PRRX1,&HOXA9,&PBX1,&ZBTB16,&MBNL1,&FBN2,&MECOM,&ZNF358

2.74

GOTERM_MF_FATGO:0030145~manganese&ion&binding 16 0.21 6.85E>03 FHIT,&GALNT2,&B3GALT2,&SMG6,&TGFBR2,&GALNTL2,&ACACA,&GALNTL1,&GALNT10,&FYN,&PPP2CB,&PDE8B,&ABL1,&GALNT9,&BMPR1A,&PC

2.17

GOTERM_BP_FATGO:0045893~positive&regulation&of&transcription,&DNA>dependent

35 0.45 7.89E>03 GLIS3,&FOXK1,&GRIP1,&GLIS1,&CTCF,&NFYB,&RORA,&PRDM16,&ZBTB38,&PLAGL1,&HOXA2,&NPAS2,&MEIS2,&MYOCD,&GATA6,&SMARCD3,&NR2F2,&FGF2,&RUNX2,&ARHGEF10L,&CIITA,&KLF12,&MAML2,&TEAD1,&CREB5,&ARID1B,&MECOM,&ATXN7L3,&ATXN1,&HDAC4,&SALL4,&ETS1,&NOTCH4,&PBX1,&SMARCA2

1.59

GOTERM_BP_FATGO:0002062~chondrocyte&differentiation

5 0.06 8.18E>03 PRKCA,&FGF18,&CHST11,&HSPG2,&RUNX2 6.01

GOTERM_BP_FATGO:0007173~epidermal&growth&factor&receptor&signaling&pathway

6 0.08 8.36E>03 EGFR,&EPS15,&NCK2,&DGKD,&ARF4,&SRC 4.64

GOTERM_BP_FATGO:0030198~extracellular&matrix&organization

12 0.15 8.40E>03 CSGALNACT1,&PTK2,&TNXB,&RXFP1,&SPOCK2,&PDGFRA,&CCDC80,&HSPG2,&COL1A1,&COL5A1,&DPT,&ANXA2

2.50

GOTERM_BP_FATGO:0048562~embryonic&organ&morphogenesis

14 0.18 8.43E>03 TGFBR2,&HSPG2,&PRRX1,&DSCAML1,&HOXB3,&SPRY2,&ATP2B2,&HOXA2,&HOXA3,&CHD7,&HOXA6,&HOXC4,&CHST11,&FRS2

2.28

GOTERM_MF_FATGO:0017076~purine&nucleotide&binding

114 1.46 8.73E>03 XRCC3,&CTPS,&PKMYT1,&ATP2B2,&PSKH1,&ATP2B4,&ARL15,&RAPGEF4,&STK39,&EGFR,&CIITA,&CARS,&OPA1,&STK24,&MYLK4,&GEM,&MAP4K3,&NAV2,&PDGFRA,&ROR1,&CAMK1,&ARL8A,&ARL8B,&EEFSEC,&SMARCA2,&MYO18A,&CLCN3,&ENPP1,&MAPKAPK5,&C9ORF98,&MYO9B,&RRAGD,&EPHB3,&TK2,&SRC,&EPHB2,&EPHB6,&PTK2,&MUSK,&VRK2,&POLQ,&RUNX2,&RAB8A,&NIN,&MYO1B,&TGFBR2,&CNKSR3,&DOCK9,&ACACA,&ATP11A,&MTHFSD,&OXSR1,&UBE2L3,&RAB7L1,&ABCB4,&NTRK3,&MYO10,&P2RX6,&PLK2,&ARF3,&ARF4,&RHEB,&RAD54B,&GRK5,&MTOR,&IKBKB,&ABL1,&PIP4K2A,&ACAD10,&ATAD2B,&PC,&MYH10,&ACOX1,&ZNFX1,&NUAK1,&PRKAG2,&ACOX3,&AKT1,&ATP8B1,&ADCY10,&PRKCA,&PIK3C2B,&PKN2,&PFKP,&PRKCH,&CDK6,&PRKCE,&PRKCB,&TXNRD1,&PRKCZ,&BRSK2,&DNAH7,&UBE2R2,&DNAH6,&GALK2,&RAB43,&CHD7,&DGKD,&SPEG,&FMO2,&DCLK2,&DNM3,&ALPK3,&ALPK2,&NPR1,&ADCY9,&GSPT1,&FYN,&ABCC4,&ABCC1,&TSSK1B,&IPPK,&ABCC6,&BMPR1A

1.24

GOTERM_BP_FATGO:0051254~positive&regulation&of&RNA&metabolic&process

35 0.45 8.88E>03 GLIS3,&FOXK1,&GRIP1,&GLIS1,&CTCF,&NFYB,&RORA,&PRDM16,&ZBTB38,&PLAGL1,&HOXA2,&NPAS2,&MEIS2,&MYOCD,&GATA6,&SMARCD3,&NR2F2,&FGF2,&RUNX2,&ARHGEF10L,&CIITA,&KLF12,&MAML2,&TEAD1,&CREB5,&ARID1B,&MECOM,&ATXN7L3,&ATXN1,&HDAC4,&SALL4,&ETS1,&NOTCH4,&PBX1,&SMARCA2

1.57

GOTERM_MF_FATGO:0004653~polypeptide&N>acetylgalactosaminyltransferase&activity

5 0.06 9.23E>03 GALNT2,&GALNT10,&GALNTL2,&GALNTL1,&GALNT9 5.81

GOTERM_BP_FATGO:0030705~cytoskeleton>dependent&intracellular&transport

8 0.10 9.46E>03 PRKCZ,&NDE1,&OPA1,&NDEL1,&MACF1,&MYO9B,&WIPF1,&MYH10 3.33

GOTERM_BP_FATGO:0030278~regulation&of&ossification 10 0.13 9.52E>03 PDLIM7,&SFRP1,&ENPP1,&GDF10,&CDK6,&PBX1,&SMURF1,&AXIN2,&RUNX2,&BMPR1A 2.77

GOTERM_BP_FATGO:0042490~mechanoreceptor&differentiation

6 0.08 9.72E>03 KCNMA1,&NTRK3,&ATP2B2,&DFNA5,&CUX1,&GPR98 4.48

GOTERM_BP_FATGO:0007411~axon&guidance 12 0.15 1.03E>02 SEMA5A,&ALCAM,&SEMA6A,&HOXA2,&PLA2G10,&GDF7,&ANK3,&RELN,&EPHB3,&MYH10,&EPHB2,&FEZ1

2.43

GOTERM_BP_FATGO:0044264~cellular&polysaccharide&metabolic&process

8 0.10 1.05E>02 CSGALNACT1,&AKT1,&GBE1,&GLT25D2,&PRKAG2,&EPM2A,&MAT2B,&EXT1 3.27

GOTERM_CC_FATGO:0044430~cytoskeletal&part 60 0.77 1.05E>02 MAD1L1,&GFAP,&PDLIM7,&TTLL8,&UTRN,&FERMT2,&TTLL5,&ADORA1,&TTLL11,&AKT1,&SPRY2,&NDE1,&PSKH1,&DLG2,&SH3PXD2A,&TANC1,&DCTN4,&TACC2,&EPB41L2,&NDEL1,&EML1,&NAV1,&KRT15,&PLA2G6,&ARL8A,&ARL8B,&MYO18A,&PRKCZ,&SHROOM3,&LITAF,&CALD1,&NEDD9,&ANLN,&MYO9B,&DNAH7,&CAPZB,&STAU2,&TPM4,&DNAH6,&NUMA1,&SORBS1,&PPP2CB,&PKD2,&WIPF1,&TRAF5,&SYNPO,&DNM3,&NIN,&MYO1B,&MAP1B,&LMNA,&SHANK2,&GAS7,&RASSF3,&MYO10,&P2RX6,&SVIL,&MAP4,&FEZ1,&MYH10

1.37

GOTERM_MF_FATGO:0046982~protein&heterodimerization&activity

19 0.24 1.08E>02 EGFR,&CLCN3,&PANX1,&TGFBR2,&ITGA2,&TPD52L1,&TPD52,&RRAGD,&ADORA1,&FOXP1,&P2RX6,&DGKD,&NOTCH4,&PPP2CB,&PDGFRA,&PBX1,&EXT1,&IKBKB,&HSD17B8

1.91

GOTERM_MF_FATGO:0032555~purine&ribonucleotide&binding

109 1.40 1.09E>02 XRCC3,&CTPS,&PKMYT1,&ATP2B2,&PSKH1,&ATP2B4,&ARL15,&RAPGEF4,&STK39,&EGFR,&CIITA,&CARS,&OPA1,&STK24,&MYLK4,&GEM,&MAP4K3,&NAV2,&PDGFRA,&ROR1,&CAMK1,&ARL8A,&ARL8B,&EEFSEC,&SMARCA2,&MYO18A,&CLCN3,&ENPP1,&MAPKAPK5,&C9ORF98,&MYO9B,&RRAGD,&EPHB3,&TK2,&SRC,&EPHB2,&EPHB6,&PTK2,&MUSK,&VRK2,&POLQ,&RUNX2,&RAB8A,&NIN,&MYO1B,&TGFBR2,&CNKSR3,&DOCK9,&ACACA,&ATP11A,&MTHFSD,&OXSR1,&UBE2L3,&RAB7L1,&ABCB4,&NTRK3,&MYO10,&P2RX6,&PLK2,&ARF3,&ARF4,&RHEB,&RAD54B,&GRK5,&MTOR,&IKBKB,&ABL1,&PIP4K2A,&ATAD2B,&PC,&MYH10,&ZNFX1,&NUAK1,&PRKAG2,&AKT1,&ATP8B1,&ADCY10,&PRKCA,&PIK3C2B,&PKN2,&PFKP,&PRKCH,&CDK6,&PRKCE,&PRKCB,&PRKCZ,&BRSK2,&DNAH7,&UBE2R2,&DNAH6,&GALK2,&RAB43,&CHD7,&DGKD,&SPEG,&DCLK2,&DNM3,&ALPK3,&ALPK2,&NPR1,&ADCY9,&GSPT1,&FYN,&ABCC4,&ABCC1,&TSSK1B,&IPPK,&ABCC6,&BMPR1A

1.24

GOTERM_MF_FATGO:0032553~ribonucleotide&binding 109 1.40 1.09E>02 XRCC3,&CTPS,&PKMYT1,&ATP2B2,&PSKH1,&ATP2B4,&ARL15,&RAPGEF4,&STK39,&EGFR,&CIITA,&CARS,&OPA1,&STK24,&MYLK4,&GEM,&MAP4K3,&NAV2,&PDGFRA,&ROR1,&CAMK1,&ARL8A,&ARL8B,&EEFSEC,&SMARCA2,&MYO18A,&CLCN3,&ENPP1,&MAPKAPK5,&C9ORF98,&MYO9B,&RRAGD,&EPHB3,&TK2,&SRC,&EPHB2,&EPHB6,&PTK2,&MUSK,&VRK2,&POLQ,&RUNX2,&RAB8A,&NIN,&MYO1B,&TGFBR2,&CNKSR3,&DOCK9,&ACACA,&ATP11A,&MTHFSD,&OXSR1,&UBE2L3,&RAB7L1,&ABCB4,&NTRK3,&MYO10,&P2RX6,&PLK2,&ARF3,&ARF4,&RHEB,&RAD54B,&GRK5,&MTOR,&IKBKB,&ABL1,&PIP4K2A,&ATAD2B,&PC,&MYH10,&ZNFX1,&NUAK1,&PRKAG2,&AKT1,&ATP8B1,&ADCY10,&PRKCA,&PIK3C2B,&PKN2,&PFKP,&PRKCH,&CDK6,&PRKCE,&PRKCB,&PRKCZ,&BRSK2,&DNAH7,&UBE2R2,&DNAH6,&GALK2,&RAB43,&CHD7,&DGKD,&SPEG,&DCLK2,&DNM3,&ALPK3,&ALPK2,&NPR1,&ADCY9,&GSPT1,&FYN,&ABCC4,&ABCC1,&TSSK1B,&IPPK,&ABCC6,&BMPR1A

1.24

GOTERM_BP_FATGO:0042493~response&to&drug 19 0.24 1.12E>02 CTPS,&SLC15A2,&TGFBR2,&MAP1B,&HIAT1,&ACACA,&ITGA2,&ABCB4,&HDAC4,&BLMH,&RAD54B,&ABCC1,&GRK5,&LRP2,&IKBKB,&SST,&SLC9A1,&ABCC6,&BCAR3

1.90

GOTERM_BP_FATGO:0009725~response&to&hormone&stimulus

28 0.36 1.14E>02 ARSB,&PNLIP,&ENPP1,&IGFBP7,&GNG12,&SRC,&AKT1,&SORBS1,&ADCY10,&PRKCA,&KCNMA1,&PNLIPRP1,&KAT2B,&BAIAP2,&TGFBR2,&MAP1B,&ITGA2,&PTPRU,&CDO1,&ABCB4,&CAPN10,&ADCY9,&PDGFRA,&TGFBR3,&COL1A1,&GNB3,&MTOR,&SST

1.65

GOTERM_BP_FATGO:0046398~UDP>glucuronate&metabolic&process

3 0.04 1.20E>02 CSGALNACT1,&SLC35D1,&UGP2 16.23

GOTERM_MF_FATGO:0051015~actin&filament&binding 8 0.10 1.25E>02 EGFR,&PKNOX2,&MACF1,&SVIL,&UTRN,&MYO9B,&GAS7,&MYH10 3.16GOTERM_BP_FATGO:0050730~regulation&of&peptidyl>

tyrosine&phosphorylation9 0.12 1.26E>02 PRKCA,&EGFR,&CSF2,&PRKCZ,&NF2,&MTOR,&PDGFD,&PRKCE,&IL22RA2 2.86

GOTERM_BP_FATGO:0048568~embryonic&organ&development

16 0.21 1.34E>02 TGFBR2,&PRRX1,&HSPG2,&DSCAML1,&HOXB3,&ATP2B2,&SPRY2,&HOXA2,&HOXA3,&CHD7,&HOXA6,&HOXC4,&CHST11,&PKD2,&PBX1,&FRS2

2.01

GOTERM_MF_FATGO:0048407~platelet>derived&growth&factor&binding

4 0.05 1.34E>02 COL4A1,&PDGFRA,&COL1A1,&COL5A1 7.60

GOTERM_MF_FATGO:0005085~guanyl>nucleotide&exchange&factor&activity

15 0.19 1.40E>02 SERGEF,&NGEF,&ABR,&DOCK9,&HERC1,&DOCK5,&ARHGEF10,&DOCK4,&PLEKHG1,&RASGRF1,&RIN2,&RAPGEF5,&RAPGEF4,&ARHGEF10L,&BCAR3

2.06

GOTERM_BP_FATGO:0006024~glycosaminoglycan&biosynthetic&process

5 0.06 1.43E>02 CSGALNACT1,&GCNT2,&SLC35D1,&CHST11,&EXT1 5.15

GOTERM_CC_FATGO:0030027~lamellipodium 9 0.12 1.44E>02 AKT1,&CTTN,&PTK2,&NF2,&NEDD9,&MYO9B,&CAPZB,&CTNNA3,&CTNNA2 2.80GOTERM_BP_FATGO:0060021~palate&development 6 0.08 1.47E>02 CHD7,&TGFBR2,&PDGFRA,&PRRX1,&TGFBR3,&BMPR1A 4.06

GOTERM_MF_FATGO:0000166~nucleotide&binding 129 1.65 1.51E>02 XRCC3,&CTPS,&PKMYT1,&RBM9,&ATP2B2,&ATP2B4,&PSKH1,&ARL15,&NT5C2,&RBMS3,&RAPGEF4,&STK39,&CIITA,&EGFR,&CARS,&OPA1,&STK24,&MYLK4,&GEM,&MAP4K3,&NAV1,&NAV2,&PDGFRA,&ROR1,&CAMK1,&ARL8A,&ARL8B,&EEFSEC,&SMARCA2,&MYO18A,&CLCN3,&ENPP1,&SETD1B,&MAPKAPK5,&C9ORF98,&MYO9B,&EPHB3,&RRAGD,&TK2,&SRC,&EPHB2,&EPHB6,&PTK2,&MUSK,&VRK2,&POLQ,&RUNX2,&SFRS12,&RAB8A,&NIN,&MYO1B,&TGFBR2,&CNKSR3,&DOCK9,&ACACA,&ATP11A,&MTHFSD,&OXSR1,&HRNBP3,&UBE2L3,&RAB7L1,&ABCB4,&NTRK3,&MYO10,&P2RX6,&PLK2,&ARF3,&ARF4,&RHEB,&RAD54B,&GRK5,&MTOR,&PIP4K2A,&ABL1,&IKBKB,&ACAD10,&ATAD2B,&PC,&MYH10,&ACOX1,&ZNFX1,&NUAK1,&PRKAG2,&CRCP,&ACOX3,&AKT1,&PARN,&CRYL1,&ATP8B1,&ADCY10,&PRKCA,&CTBP1,&CTBP2,&PIK3C2B,&PFKP,&PKN2,&PRKCH,&CDK6,&PRKCE,&PRKCB,&TXNRD1,&PRKCZ,&BRSK2,&DNAH7,&UBE2R2,&DNAH6,&GALK2,&RAB43,&CHD7,&SPEG,&DGKD,&FMO2,&DCLK2,&MSI2,&DNM3,&ALPK3,&ALPK2,&NPR1,&DACH1,&ADCY9,&GSPT1,&FYN,&A2BP1,&ABCC4,&ABCC1,&TSSK1B,&IPPK,&ABCC6,&BMPR1A

1.20

GOTERM_BP_FATGO:0048870~cell&motility 24 0.31 1.53E>02 PLAT,&PRKCA,&CX3CL1,&DNAH7,&COL5A1,&SRC,&CTNNA2,&NCK2,&NDE1,&PTK2,&TNS1,&NDEL1,&GAB2,&CD44,&ITGA5,&ETS1,&FYN,&TGFBR3,&VCAN,&RELN,&NR2F2,&FGF2,&PPAP2B,&MYH10

1.69

GOTERM_BP_FATGO:0051674~localization&of&cell 24 0.31 1.53E>02 PLAT,&PRKCA,&CX3CL1,&DNAH7,&COL5A1,&SRC,&CTNNA2,&NCK2,&NDE1,&PTK2,&TNS1,&NDEL1,&GAB2,&CD44,&ITGA5,&ETS1,&FYN,&TGFBR3,&VCAN,&RELN,&NR2F2,&FGF2,&PPAP2B,&MYH10

1.69

GOTERM_MF_FATGO:0019992~diacylglycerol&binding 9 0.12 1.53E>02 PRKCA,&PRKCZ,&PDZD8,&PLEKHM3,&DGKD,&PRKCH,&MYO9B,&PRKCE,&PRKCB 2.77GOTERM_CC_FATGO:0005583~fibrillar&collagen 4 0.05 1.55E>02 TNXB,&COL27A1,&COL1A1,&COL5A1 7.26GOTERM_CC_FATGO:0014069~postsynaptic&density 9 0.12 1.56E>02 DNM3,&P2RX6,&CALD1,&MAP1B,&TANC1,&ADORA1,&SHANK2,&DLG2,&SYNPO 2.76GOTERM_BP_FATGO:0060389~pathway>restricted&

SMAD&protein&phosphorylation4 0.05 1.57E>02 GDF7,&GDF6,&TGFBR2,&TGFBR3 7.21

GOTERM_BP_FATGO:0001958~endochondral&ossification

4 0.05 1.57E>02 FGF18,&HSPG2,&COL1A1,&RUNX2 7.21

GOTERM_CC_FATGO:0031594~neuromuscular&junction 5 0.06 1.66E>02 MUSK,&RAPSN,&UTRN,&SV2A,&MYH10 4.95GOTERM_BP_FATGO:0055067~monovalent&inorganic&

cation&homeostasis7 0.09 1.66E>02 KCNMA1,&SLC9A9,&CLCN3,&ATP6V1H,&NEDD4L,&ATP6V0A4,&SLC9A1 3.37

GOTERM_CC_FATGO:0005938~cell&cortex 14 0.18 1.67E>02 PRKCZ,&CALD1,&FERMT2,&UTRN,&NEDD9,&MYO9B,&ANLN,&CAPZB,&FLNB,&EPB41L2,&CTTN,&MACF1,&GRM7,&MYH10

2.09

GOTERM_BP_FATGO:0045937~positive&regulation&of&phosphate&metabolic&process

11 0.14 1.69E>02 PRKCA,&EGFR,&CSF2,&GDF7,&GDF6,&PRKAG2,&MTOR,&FAM129A,&ADORA1,&FGF2,&BMPR1A

2.38

GOTERM_BP_FATGO:0010562~positive&regulation&of&phosphorus&metabolic&process

11 0.14 1.69E>02 PRKCA,&EGFR,&CSF2,&GDF7,&GDF6,&PRKAG2,&MTOR,&FAM129A,&ADORA1,&FGF2,&BMPR1A

2.38

GOTERM_BP_FATGO:0016477~cell&migration 22 0.28 1.70E>02 PLAT,&PRKCA,&CX3CL1,&COL5A1,&SRC,&CTNNA2,&NCK2,&NDE1,&PTK2,&TNS1,&NDEL1,&GAB2,&CD44,&ITGA5,&FYN,&TGFBR3,&VCAN,&RELN,&NR2F2,&FGF2,&PPAP2B,&MYH10

1.73

GOTERM_MF_FATGO:0008022~protein&C>terminus&binding

14 0.18 1.74E>02 CIITA,&CTBP1,&BAIAP2,&CNKSR3,&ZBTB16,&SLC9A3R1,&SRC,&FOXN3,&ATXN1,&ATP2B2,&A2BP1,&PPP2CB,&PKD2,&ABL1

2.08

GOTERM_CC_FATGO:0009986~cell&surface 26 0.33 1.77E>02 FRAS1,&TM7SF4,&CD244,&CLCN3,&RTN4RL1,&CD8A,&ENPP1,&DSCAML1,&CX3CL1,&ALCAM,&RGMA,&CD44,&DPP4,&KCNMA1,&IL2RA,&F10,&TGFBR2,&ITGA2,&GPR98,&CD36,&ITGA5,&FREM2,&CD59,&CDON,&NOTCH4,&TGFBR3

1.63

GOTERM_BP_FATGO:0010810~regulation&of&cell>substrate&adhesion

7 0.09 1.83E>02 PRKCZ,&CD36,&NF2,&CCDC80,&VWC2,&CDK6,&COL1A1 3.29

GOTERM_BP_FATGO:0051094~positive&regulation&of&developmental&process

22 0.28 1.83E>02 PRKCA,&CSF2,&IL2RA,&PDLIM7,&PLA2G10,&TGFBR2,&MAP1B,&IL21,&EPHB2,&AKT1,&NTRK3,&SMAP1,&CD36,&NDEL1,&GATA6,&ETS1,&VWC2,&CAMK1,&FGF2,&RUNX2,&FNDC3B,&BMPR1A

1.71

GOTERM_BP_FATGO:0031399~regulation&of&protein&modification&process

23 0.29 1.84E>02 PRKCA,&EGFR,&CSF2,&PRKCZ,&NF2,&ENPP1,&GDF7,&GDF6,&PRKAG2,&PRKCE,&ADORA1,&HDAC4,&ATG7,&RAPGEF4,&MTOR,&ANAPC7,&SMURF1,&PDGFD,&FAM129A,&FGF2,&PSMD9,&IL22RA2,&BMPR1A

1.69

GOTERM_CC_FATGO:0044456~synapse&part 20 0.26 1.86E>02 KCNMA1,&DNM3,&GRIP1,&CALD1,&UTRN,&MAP1B,&TANC1,&ADORA1,&SHANK2,&PRR7,&P2RX6,&GRM8,&STXBP5,&RAPSN,&GRM7,&SV2B,&SV2A,&SLC40A1,&DLG2,&SYNPO

1.77

GOTERM_BP_FATGO:0051642~centrosome&localization 3 0.04 1.94E>02 SEMA6A,&NDEL1,&NIN 12.99GOTERM_BP_FATGO:0045056~transcytosis 3 0.04 1.94E>02 TG,&LRP2,&SRC 12.99GOTERM_BP_FATGO:0019585~glucuronate&metabolic&

process3 0.04 1.94E>02 CSGALNACT1,&SLC35D1,&UGP2 12.99

GOTERM_BP_FATGO:0001957~intramembranous&ossification

3 0.04 1.94E>02 FGF18,&COL1A1,&AXIN2 12.99

GOTERM_BP_FATGO:0006063~uronic&acid&metabolic&process

3 0.04 1.94E>02 CSGALNACT1,&SLC35D1,&UGP2 12.99

GOTERM_BP_FATGO:0006023~aminoglycan&biosynthetic&process

5 0.06 1.97E>02 CSGALNACT1,&GCNT2,&SLC35D1,&CHST11,&EXT1 4.71

GOTERM_BP_FATGO:0050974~detection&of&mechanical&stimulus&involved&in&sensory&perception

4 0.05 1.98E>02 ATP2B2,&FYN,&ITGA2,&GPR98 6.66

GOTERM_BP_FATGO:0045785~positive&regulation&of&cell&adhesion

8 0.10 1.99E>02 PRKCZ,&CD36,&CCDC80,&VWC2,&ITGA2,&CDK6,&CX3CL1,&SRC 2.89

GOTERM_BP_FATGO:0016055~Wnt&receptor&signaling&pathway

13 0.17 1.99E>02 NKD1,&NKD2,&TLE3,&TLE4,&PTPRU,&SLC9A3R1,&WNT2B,&WISP1,&NXN,&SFRP1,&MACF1,&SFRP4,&AXIN2

2.12

GOTERM_CC_FATGO:0005794~Golgi&apparatus 54 0.69 2.07E>02 ARSB,&NDST4,&PKMYT1,&CBFA2T3,&ST3GAL1,&ST3GAL3,&PSKH1,&CD44,&ANK3,&SND1,&SLC35D2,&CHST11,&PDGFD,&DPP4,&GALNTL2,&GALNTL1,&HERC1,&ERGIC1,&CD36,&TRAPPC9,&IGF2R,&CHSY1,&PTGFRN,&LEPREL1,&EXT1,&CUX1,&GALNT9,&MYO18A,&TG,&GALNT2,&CLCN3,&GCNT3,&GCNT2,&LITAF,&NEDD9,&SEC14L1,&GALNT10,&AP3M2,&PKD1,&PPAP2B,&RNF122,&C11ORF2,&B3GALT2,&UST,&PARK2,&ABCB4,&CSGALNACT1,&RAPSN,&A2BP1,&ARF3,&ARF4,&MTOR,&LRP2,&GOLGB1

1.35

GOTERM_BP_FATGO:0045934~negative&regulation&of&nucleobase,&nucleoside,&nucleotide&and&nucleic&acid&metabolic&process

35 0.45 2.09E>02 GLIS3,&FOXK1,&GLIS1,&CTCF,&ZBTB16,&RBM9,&PRDM16,&NR2C1,&HOXA2,&MEIS2,&ATP8B1,&LRRFIP1,&NR2F2,&FGF2,&RUNX2,&MYST4,&ZNF423,&CIITA,&CTBP1,&CTBP2,&KLF12,&NF2,&LMCD1,&NR0B2,&PTPRU,&FOXP1,&FOXN3,&ATXN1,&HDAC4,&SALL4,&GRM8,&PRDM6,&GRM7,&CUX1,&SMARCA2

1.48

GOTERM_BP_FATGO:0010906~regulation&of&glucose&metabolic&process

6 0.08 2.12E>02 AKT1,&HDAC4,&SORBS1,&ENPP1,&PRKAG2,&MTOR 3.71

GOTERM_BP_FATGO:0007507~heart&development 18 0.23 2.15E>02 ALPK3,&TGFBR2,&HSPG2,&TEAD1,&MECOM,&COL5A1,&FOXP1,&CHD7,&SALL4,&OSR1,&MYOCD,&SMARCD3,&GATA6,&PKD2,&PKD1,&TGFBR3,&MYH10,&BMPR1A

1.81

GOTERM_BP_FATGO:0016481~negative&regulation&of&transcription

32 0.41 2.17E>02 GLIS3,&FOXK1,&GLIS1,&CTCF,&ZBTB16,&RBM9,&PRDM16,&NR2C1,&HOXA2,&MEIS2,&ATP8B1,&LRRFIP1,&NR2F2,&FGF2,&RUNX2,&MYST4,&ZNF423,&CIITA,&CTBP1,&CTBP2,&KLF12,&LMCD1,&NR0B2,&PTPRU,&FOXN3,&FOXP1,&ATXN1,&HDAC4,&SALL4,&PRDM6,&CUX1,&SMARCA2

1.51

GOTERM_MF_FATGO:0015299~solute:hydrogen&antiporter&activity

5 0.06 2.21E>02 SLC9A9,&HIAT1,&TMCO3,&SLC9A11,&SLC9A1 4.54

GOTERM_BP_FATGO:0007389~pattern&specification&process

21 0.27 2.27E>02 SHROOM3,&TGFBR2,&DSCAML1,&ZBTB16,&SEMA5A,&HOXB3,&HOXA2,&HOXA3,&SFRP1,&DISP1,&HOXA6,&HOXC4,&NOTCH4,&PKD2,&HOXA9,&PBX1,&RELN,&AXIN2,&NR2F2,&FRS2,&BMPR1A

1.70

GOTERM_BP_FATGO:0060113~inner&ear&receptor&cell&differentiation

5 0.06 2.28E>02 KCNMA1,&ATP2B2,&DFNA5,&CUX1,&GPR98 4.51

GOTERM_BP_FATGO:0001101~response&to&acid 5 0.06 2.28E>02 MTOR,&CDO1,&SST,&SRC,&SLC9A1 4.51GOTERM_BP_FATGO:0005979~regulation&of&glycogen&

biosynthetic&process4 0.05 2.43E>02 AKT1,&SORBS1,&ENPP1,&MTOR 6.18

GOTERM_BP_FATGO:0010962~regulation&of&glucan&biosynthetic&process

4 0.05 2.43E>02 AKT1,&SORBS1,&ENPP1,&MTOR 6.18

GOTERM_BP_FATGO:0032233~positive&regulation&of&actin&filament&bundle&formation

4 0.05 2.43E>02 NF2,&MTOR,&ARHGEF10L,&SYNPO 6.18

GOTERM_BP_FATGO:0032885~regulation&of&polysaccharide&biosynthetic&process


GOTERM_MF_FATGO:0005088~Ras&guanyl>nucleotide&exchange&factor&activity

10 0.13 2.43E>02 NGEF,&SERGEF,&PLEKHG1,&ABR,&RASGRF1,&DOCK9,&RIN2,&RAPGEF5,&ARHGEF10L,&ARHGEF10

2.38

GOTERM_CC_FATGO:0009897~external&side&of&plasma&membrane

15 0.19 2.45E>02 FRAS1,&KCNMA1,&CD244,&IL2RA,&F10,&CD8A,&RTN4RL1,&TGFBR2,&ITGA2,&ALCAM,&CD44,&FREM2,&ITGA5,&CD59,&TGFBR3

1.92

GOTERM_BP_FATGO:0051172~negative&regulation&of&nitrogen&compound&metabolic&process

35 0.45 2.50E>02 GLIS3,&FOXK1,&GLIS1,&CTCF,&ZBTB16,&RBM9,&PRDM16,&NR2C1,&HOXA2,&MEIS2,&ATP8B1,&LRRFIP1,&NR2F2,&FGF2,&RUNX2,&MYST4,&ZNF423,&CIITA,&CTBP1,&CTBP2,&KLF12,&NF2,&LMCD1,&NR0B2,&PTPRU,&FOXP1,&FOXN3,&ATXN1,&HDAC4,&SALL4,&GRM8,&PRDM6,&GRM7,&CUX1,&SMARCA2

1.46

GOTERM_BP_FATGO:0006163~purine&nucleotide&metabolic&process

16 0.21 2.54E>02 ENPP1,&PRKAG2,&ATP11A,&NPR1,&ATP6V1H,&MYO9B,&RORA,&AMPD1,&ATP2B2,&ATP2B4,&ADCY9,&ATP8B1,&PDE8B,&ATP6V0A4,&ADCY10,&ABCC6

1.86

GOTERM_CC_FATGO:0043005~neuron&projection 25 0.32 2.55E>02 CALD1,&UTRN,&ADORA1,&ALCAM,&ATP2B2,&NUMA1,&ANK3,&SYNPO,&KCNMA1,&DNM3,&NGEF,&OPA1,&MAP1B,&ITGA2,&PARK2,&CTNNA2,&SEMA6A,&P2RX6,&NDEL1,&GRM8,&RASGRF1,&GRM7,&RELN,&MTOR,&MYH10

1.59

GOTERM_BP_FATGO:0006493~protein&amino&acid&O>linked&glycosylation

5 0.06 2.62E>02 GALNT2,&GCNT3,&GALNT10,&TRAK1,&GALNT9 4.33

GOTERM_BP_FATGO:0051174~regulation&of&phosphorus&metabolic&process

33 0.42 2.66E>02 CSF2,&PRKCZ,&ENPP1,&GDF7,&GDF6,&PRKAG2,&LPAR3,&PKMYT1,&ADORA1,&AKT1,&SPRY2,&DGKD,&RAPGEF4,&PDGFD,&ADCY10,&FAM129A,&FGF2,&FRS2,&PRKCA,&EGFR,&NF2,&SMG6,&TGFBR2,&ITGA2,&PRKCE,&ATXN1,&NCK2,&ADCY9,&RGS3,&RELN,&MTOR,&BMPR1A,&IL22RA2

1.47

GOTERM_BP_FATGO:0019220~regulation&of&phosphate&metabolic&process

33 0.42 2.66E>02 CSF2,&PRKCZ,&ENPP1,&GDF7,&GDF6,&PRKAG2,&LPAR3,&PKMYT1,&ADORA1,&AKT1,&SPRY2,&DGKD,&RAPGEF4,&PDGFD,&ADCY10,&FAM129A,&FGF2,&FRS2,&PRKCA,&EGFR,&NF2,&SMG6,&TGFBR2,&ITGA2,&PRKCE,&ATXN1,&NCK2,&ADCY9,&RGS3,&RELN,&MTOR,&BMPR1A,&IL22RA2

1.47

GOTERM_BP_FATGO:0044272~sulfur&compound&biosynthetic&process

7 0.09 2.67E>02 CSGALNACT1,&SLC35D1,&CHST11,&GGT1,&MAT2B,&EXT1,&CDO1 3.03

GOTERM_BP_FATGO:0010629~negative&regulation&of&gene&expression

34 0.44 2.74E>02 GLIS3,&FOXK1,&GLIS1,&CTCF,&ZBTB16,&RBM9,&PRDM16,&NR2C1,&HOXA2,&MEIS2,&WWP2,&SND1,&ATP8B1,&LRRFIP1,&NR2F2,&FGF2,&RUNX2,&MYST4,&ZNF423,&CIITA,&CTBP1,&CTBP2,&KLF12,&LMCD1,&NR0B2,&PTPRU,&FOXP1,&FOXN3,&ATXN1,&HDAC4,&SALL4,&PRDM6,&CUX1,&SMARCA2

1.46

GOTERM_BP_FATGO:0042127~regulation&of&cell&proliferation

49 0.63 2.81E>02 DLEC1,&FGF18,&IGFBP7,&PRRX1,&RBM9,&ADORA1,&MYOCD,&TICAM1,&CHST11,&GLP2R,&FGF2,&EGFR,&PRKCA,&CTBP1,&CTBP2,&CDK6,&PTPRU,&MECOM,&IL21,&NCK2,&PDGFRA,&PMP22,&SMARCA2,&PRKCZ,&CSF2,&CNTFR,&ZBTB16,&CDH5,&HOXA3,&SPEG,&AXIN2,&TRAF5,&RUNX2,&DPT,&KAT2B,&IL2RA,&NF2,&TGFBR2,&ITGA2,&FOXP1,&HDAC4,&ETS1,&BNC1,&NOTCH4,&TGFBR3,&PBX1,&MTOR,&SST,&BMPR1A

1.35

GOTERM_BP_FATGO:0031327~negative&regulation&of&cellular&biosynthetic&process

37 0.47 2.83E>02 GLIS3,&FOXK1,&ENPP1,&GLIS1,&CTCF,&ZBTB16,&PRDM16,&RBM9,&NR2C1,&HOXA2,&MEIS2,&ATP8B1,&LRRFIP1,&NR2F2,&FGF2,&RUNX2,&MYST4,&ZNF423,&CIITA,&PRKCA,&CTBP1,&CTBP2,&KLF12,&NF2,&LMCD1,&NR0B2,&PTPRU,&FOXP1,&FOXN3,&ATXN1,&HDAC4,&SALL4,&GRM8,&PRDM6,&GRM7,&CUX1,&SMARCA2

1.43

GOTERM_BP_FATGO:0009952~anterior/posterior&pattern&formation

13 0.17 2.84E>02 ZBTB16,&HOXB3,&HOXA2,&HOXA3,&SFRP1,&HOXC4,&HOXA6,&HOXA9,&PBX1,&NR2F2,&AXIN2,&FRS2,&BMPR1A

2.01

GOTERM_MF_FATGO:0046983~protein&dimerization&activity

37 0.47 2.85E>02 CLCN3,&BACH2,&PANX1,&CD8A,&ENPP1,&DSCAML1,&MYO9B,&ZBTB16,&TPD52,&RRAGD,&ADORA1,&NR2C1,&CRYL1,&DGKD,&ATG7,&PPP2CB,&TEF,&DPP4,&HSD17B8,&EGFR,&CARS,&PTPRE,&TGFBR2,&ITGA2,&TPD52L1,&CREB5,&NR0B2,&FOXP1,&P2RX6,&PRDM6,&NOTCH4,&PDGFRA,&NFE2L1,&PBX1,&EXT1,&IKBKB,&BMPR1A

1.43

GOTERM_BP_FATGO:0048839~inner&ear&development 9 0.12 2.88E>02 KCNMA1,&ATP2B2,&SPRY2,&DFNA5,&CHD7,&PDGFRA,&PRRX1,&CUX1,&GPR98 2.47GOTERM_BP_FATGO:0010675~regulation&of&cellular&

carbohydrate&metabolic&process6 0.08 2.93E>02 AKT1,&HDAC4,&SORBS1,&ENPP1,&PRKAG2,&MTOR 3.42

GOTERM_BP_FATGO:0009187~cyclic&nucleotide&metabolic&process

6 0.08 2.93E>02 ATP2B2,&ADCY9,&NPR1,&PDE8B,&RORA,&ADCY10 3.42

GOTERM_BP_FATGO:0009268~response&to&pH 4 0.05 2.94E>02 KCNMA1,&TG,&ARSB,&SLC9A1 5.77GOTERM_BP_FATGO:0032881~regulation&of&

polysaccharide&metabolic&process4 0.05 2.94E>02 AKT1,&SORBS1,&ENPP1,&MTOR 5.77

GOTERM_BP_FATGO:0010876~lipid&localization 14 0.18 2.97E>02 SOAT1,&PNLIP,&HDLBP,&ENPP1,&PLA2G10,&SORL1,&ATP11A,&CD36,&ATP8B1,&LIPG,&OSBPL10,&PITPNC1,&C11ORF2,&APOL5

1.93

GOTERM_BP_FATGO:0046677~response&to&antibiotic 5 0.06 2.99E>02 PRKCA,&CIITA,&ETS1,&HIAT1,&PPP2CB 4.16GOTERM_BP_FATGO:0043583~ear&development 10 0.13 3.10E>02 KCNMA1,&ATP2B2,&SPRY2,&DFNA5,&HOXA2,&CHD7,&PDGFRA,&PRRX1,&CUX1,&GPR98 2.28GOTERM_BP_FATGO:0009101~glycoprotein&

biosynthetic&process14 0.18 3.11E>02 GALNT2,&GCNT3,&B3GALT2,&MAN1B1,&ST3GAL1,&CSGALNACT1,&ST3GAL3,&GALNT10,&

SLC35D1,&CHST11,&TRAK1,&LRP2,&EXT1,&GALNT91.92

GOTERM_BP_FATGO:0042060~wound&healing 16 0.21 3.11E>02 PLAT,&F10,&TGFBR2,&ITGA2,&COL5A1,&DYSF,&HMCN1,&CD36,&CD44,&ITGA5,&CD59,&TFPI,&PDGFRA,&PROS1,&FGF2,&MYH10

1.81

GOTERM_MF_FATGO:0008047~enzyme&activator&activity

25 0.32 3.13E>02 PPP1R12B,&PRKAG2,&IQGAP2,&MYO9B,&ARHGAP15,&ARHGAP12,&GARNL3,&SMAP1,&RGS12,&TBC1D14,&TBC1D5,&GIT2,&RAP1GAP2,&RASA3,&FRS2,&ARHGEF10L,&TBC1D2B,&DAB2IP,&ABR,&DOCK4,&RGS3,&RGS5,&RIN2,&ARAP2,&MGST2

1.56

GOTERM_BP_FATGO:0005976~polysaccharide&metabolic&process

11 0.14 3.22E>02 CSGALNACT1,&AKT1,&GCNT2,&GBE1,&GLT25D2,&SLC35D1,&PRKAG2,&CHST11,&EPM2A,&MAT2B,&EXT1

2.14

GOTERM_BP_FATGO:0006109~regulation&of&carbohydrate&metabolic&process

6 0.08 3.24E>02 AKT1,&HDAC4,&SORBS1,&ENPP1,&PRKAG2,&MTOR 3.33

GOTERM_MF_FATGO:0017048~Rho&GTPase&binding 6 0.08 3.33E>02 FMNL2,&DOCK9,&MYO9B,&DAAM1,&DAAM2,&DOCK4 3.30GOTERM_BP_FATGO:0042327~positive&regulation&of&

phosphorylation10 0.13 3.48E>02 PRKCA,&EGFR,&CSF2,&GDF7,&GDF6,&PRKAG2,&MTOR,&FAM129A,&FGF2,&BMPR1A 2.23

GOTERM_BP_FATGO:0060350~endochondral&bone&morphogenesis

4 0.05 3.49E>02 FGF18,&HSPG2,&COL1A1,&RUNX2 5.41

GOTERM_BP_FATGO:0007172~signal&complex&assembly 4 0.05 3.49E>02 NCK2,&MUSK,&PTK2,&SRC 5.41

GOTERM_BP_FATGO:0009719~response&to&endogenous&stimulus

28 0.36 3.53E>02 ARSB,&PNLIP,&ENPP1,&IGFBP7,&GNG12,&SRC,&AKT1,&SORBS1,&ADCY10,&PRKCA,&KCNMA1,&PNLIPRP1,&KAT2B,&BAIAP2,&TGFBR2,&MAP1B,&ITGA2,&PTPRU,&CDO1,&ABCB4,&CAPN10,&ADCY9,&PDGFRA,&TGFBR3,&COL1A1,&GNB3,&MTOR,&SST

1.50

GOTERM_BP_FATGO:0006869~lipid&transport 13 0.17 3.59E>02 SOAT1,&PNLIP,&HDLBP,&PLA2G10,&SORL1,&ATP11A,&CD36,&ATP8B1,&LIPG,&OSBPL10,&PITPNC1,&APOL5,&C11ORF2

1.94

GOTERM_BP_FATGO:0009890~negative&regulation&of&biosynthetic&process

37 0.47 3.72E>02 GLIS3,&FOXK1,&ENPP1,&GLIS1,&CTCF,&ZBTB16,&PRDM16,&RBM9,&NR2C1,&HOXA2,&MEIS2,&ATP8B1,&LRRFIP1,&NR2F2,&FGF2,&RUNX2,&MYST4,&ZNF423,&CIITA,&PRKCA,&CTBP1,&CTBP2,&KLF12,&NF2,&LMCD1,&NR0B2,&PTPRU,&FOXP1,&FOXN3,&ATXN1,&HDAC4,&SALL4,&GRM8,&PRDM6,&GRM7,&CUX1,&SMARCA2

1.40

GOTERM_BP_FATGO:0030031~cell&projection&assembly 9 0.12 3.72E>02 DNM3,&NCK2,&RAB8A,&BAIAP2,&LPAR3,&MTSS1L,&CAPZB,&MYH10,&VCL 2.35GOTERM_CC_FATGO:0048786~presynaptic&active&zone 3 0.04 3.78E>02 KCNMA1,&GRM7,&ADORA1 9.33GOTERM_BP_FATGO:0019935~cyclic>nucleotide>

mediated&signaling12 0.15 3.79E>02 CD36,&RXFP1,&ADCY9,&PDE7A,&HRH2,&LPAR3,&RAPGEF4,&GLP2R,&GRK5,&CORT,&

ADCY10,&ADORA12.00

GOTERM_BP_FATGO:0010811~positive&regulation&of&cell>substrate&adhesion

5 0.06 3.81E>02 PRKCZ,&CD36,&CCDC80,&VWC2,&CDK6 3.87

GOTERM_BP_FATGO:0060216~definitive&hemopoiesis 3 0.04 3.82E>02 HOXB3,&TGFBR3,&HOXA9 9.28GOTERM_BP_FATGO:0007185~transmembrane&

receptor&protein&tyrosine&phosphatase&signaling&pathway

3 0.04 3.82E>02 PTPRE,&PTPRU,&FRS2 9.28

GOTERM_BP_FATGO:0002063~chondrocyte&development

3 0.04 3.82E>02 FGF18,&CHST11,&RUNX2 9.28

GOTERM_CC_FATGO:0005884~actin&filament 6 0.08 3.83E>02 PRKCZ,&CALD1,&FERMT2,&MYO9B,&WIPF1,&GAS7 3.19GOTERM_BP_FATGO:0010648~negative&regulation&of&

cell&communication19 0.24 3.86E>02 PRKCA,&PRKCZ,&NF2,&ENPP1,&PRDM16,&ADORA1,&AKT1,&RGS22,&ATXN1,&RGS12,&

RGS3,&CHST11,&PPP2CB,&RGS5,&VWC2,&MTOR,&SMURF1,&AXIN2,&RUNX21.66

GOTERM_BP_FATGO:0034637~cellular&carbohydrate&biosynthetic&process

8 0.10 3.92E>02 CSGALNACT1,&AKT1,&GBE1,&GLT25D2,&MAT2B,&FBP2,&EXT1,&PC 2.51

GOTERM_BP_FATGO:0003002~regionalization 16 0.21 3.93E>02 DSCAML1,&ZBTB16,&HOXB3,&HOXA2,&HOXA3,&SFRP1,&DISP1,&HOXA6,&HOXC4,&HOXA9,&RELN,&PBX1,&AXIN2,&NR2F2,&FRS2,&BMPR1A

1.76

GOTERM_MF_FATGO:0004091~carboxylesterase&activity 10 0.13 3.96E>02 PNLIP,&PNLIPRP1,&ACOT7,&AADACL4,&PLA2G10,&LIPG,&ESD,&ACOT2,&PLA2G6,&ABHD12 2.18

GOTERM_BP_FATGO:0009141~nucleoside&triphosphate&metabolic&process

12 0.15 3.97E>02 ATP2B2,&ATP2B4,&ENPP1,&CTPS,&ENPP3,&PRKAG2,&ATP8B1,&ATP6V1H,&ATP11A,&MYO9B,&ATP6V0A4,&ABCC6

1.98

GOTERM_MF_FATGO:0060090~molecular&adaptor&activity

8 0.10 4.00E>02 SHB,&NCK2,&SORBS1,&BAIAP2,&SH3BGR,&MTSS1L,&FRS2,&SRC 2.50

GOTERM_MF_FATGO:0008289~lipid&binding 31 0.40 4.07E>02 PRKCZ,&HDLBP,&PLEKHM3,&LPAR3,&MYO9B,&PAQR5,&AKT1,&ACOT7,&DGKD,&PITPNC1,&SOAT1,&PRKCA,&F10,&SH3PXD2A,&PIK3C2B,&SNX25,&MAP1B,&PRKCH,&PRKCE,&ZCCHC14,&ANXA2,&PRKCB,&CADPS,&PITPNM2,&PDZD8,&CD36,&PLEKHA5,&GRK5,&ARAP2,&EPN1,&APOL5

1.44

GOTERM_CC_FATGO:0044463~cell&projection&part 18 0.23 4.09E>02 KCNMA1,&DNM3,&TTLL8,&CALD1,&ITGA2,&TTLL5,&DNAH7,&ADORA1,&TTLL11,&P2RX6,&PEX19,&ITGA5,&GRM7,&PKD2,&LRP2,&ATP6V0A4,&MYH10,&SYNPO

1.68

GOTERM_BP_FATGO:0002053~positive&regulation&of&mesenchymal&cell&proliferation

4 0.05 4.10E>02 TGFBR2,&PRRX1,&FOXP1,&BMPR1A 5.09

GOTERM_BP_FATGO:0042325~regulation&of&phosphorylation

31 0.40 4.12E>02 CSF2,&PRKCZ,&ENPP1,&GDF7,&GDF6,&PRKAG2,&LPAR3,&PKMYT1,&ADORA1,&AKT1,&SPRY2,&DGKD,&RAPGEF4,&PDGFD,&ADCY10,&FAM129A,&FGF2,&FRS2,&PRKCA,&EGFR,&NF2,&TGFBR2,&PRKCE,&ATXN1,&NCK2,&ADCY9,&RGS3,&RELN,&MTOR,&BMPR1A,&IL22RA2

1.44

GOTERM_BP_FATGO:0032270~positive&regulation&of&cellular&protein&metabolic&process

18 0.23 4.18E>02 PRKCA,&CSF2,&PLA2G10,&GDF7,&GDF6,&PRKAG2,&ITGA2,&ADORA1,&AKT1,&HDAC4,&ATG7,&ANAPC7,&SMURF1,&MTOR,&FAM129A,&FGF2,&PSMD9,&BMPR1A

1.67

GOTERM_BP_FATGO:0007229~integrin>mediated&signaling&pathway

8 0.10 4.19E>02 ITGA9,&PTK2,&GAB2,&ITGA5,&ITGB5,&ITGA2,&NEDD9,&ADAM22 2.47

GOTERM_BP_FATGO:0007369~gastrulation 8 0.10 4.19E>02 MACF1,&NF2,&TXNRD1,&EXT1,&FRS2,&PPAP2B,&BMPR1A,&ODZ4 2.47GOTERM_BP_FATGO:0007242~intracellular&signaling&

cascade72 0.92 4.19E>02 PLEKHM3,&GRIP1,&PRKAG2,&IQGAP2,&LPAR3,&RBM9,&ADORA1,&AKT1,&TICAM1,&

RAPGEF5,&RAPGEF4,&GLP2R,&ADCY10,&FRS2,&FGF2,&PRKCA,&EGFR,&RXFP1,&RREB1,&PIK3C2B,&DMRT1,&PRKCH,&GEM,&PRKCE,&FOXN3,&PRKCB,&MAP4K3,&LAT2,&CD36,&RASGRF1,&RIN2,&ARL8A,&GNB3,&ARL8B,&ASB2,&PMEPA1,&PRKCZ,&STYXL1,&MYO9B,&GNG12,&SRC,&RAB43,&DGKD,&HRH2,&PLCH1,&PKD2,&PKD1,&DCLK2,&RASA3,&RAB8A,&ABR,&NPR1,&OXSR1,&RAB7L1,&SHANK2,&PDZD8,&ADCY9,&RGS3,&PDE7A,&FYN,&ARF3,&ARF4,&NOTCH4,&RHEB,&TGFBR3,&GRK5,&MTOR,&IKBKB,&CORT,&ABL1,&SLC9A1,&BCAR3

1.24

GOTERM_BP_FATGO:0031960~response&to&corticosteroid&stimulus

9 0.12 4.20E>02 PRKCA,&KCNMA1,&PNLIPRP1,&IGFBP7,&COL1A1,&PTPRU,&CDO1,&SRC,&ABCB4 2.29

GOTERM_BP_FATGO:0010970~microtubule>based&transport

5 0.06 4.26E>02 PRKCZ,&NDE1,&OPA1,&NDEL1,&MACF1 3.73

GOTERM_BP_FATGO:0043393~regulation&of&protein&binding

5 0.06 4.26E>02 HDAC4,&SMARCD3,&CALD1,&TICAM1,&ITGA2 3.73

GOTERM_BP_FATGO:0032870~cellular&response&to&hormone&stimulus

12 0.15 4.36E>02 AKT1,&CAPN10,&KAT2B,&SORBS1,&ENPP1,&ADCY9,&IGFBP7,&BAIAP2,&ITGA2,&GNG12,&GNB3,&ADCY10

1.95

GOTERM_BP_FATGO:0008284~positive&regulation&of&cell&proliferation

28 0.36 4.37E>02 CSF2,&FGF18,&PRKCZ,&PRRX1,&CNTFR,&HOXA3,&MYOCD,&TICAM1,&GLP2R,&FGF2,&RUNX2,&TRAF5,&PRKCA,&EGFR,&IL2RA,&TGFBR2,&ITGA2,&CDK6,&IL21,&FOXP1,&HDAC4,&NCK2,&NOTCH4,&BNC1,&PDGFRA,&PBX1,&MTOR,&BMPR1A

1.46

GOTERM_CC_FATGO:0015630~microtubule&cytoskeleton

35 0.45 4.59E>02 MAD1L1,&SHROOM3,&TTLL8,&LITAF,&NEDD9,&TTLL5,&DNAH7,&STAU2,&DNAH6,&TTLL11,&AKT1,&SPRY2,&NUMA1,&NDE1,&PSKH1,&MACF1,&PPP2CB,&PKD2,&TRAF5,&DNM3,&NIN,&MAP1B,&DCTN4,&TACC2,&RASSF3,&PKNOX2,&EML1,&NDEL1,&NAV1,&PLA2G6,&MAP4,&ARL8A,&ARL8B,&MYH10,&FEZ1

1.39

GOTERM_BP_FATGO:0030336~negative&regulation&of&cell&migration

7 0.09 4.66E>02 NF2,&CLIC4,&TGFBR3,&PTPRU,&ADORA1,&FGF2,&VCL 2.66

GOTERM_BP_FATGO:0008285~negative&regulation&of&cell&proliferation

25 0.32 4.69E>02 DLEC1,&IGFBP7,&ZBTB16,&ADORA1,&CDH5,&SPEG,&AXIN2,&FGF2,&DPT,&PRKCA,&CTBP1,&CTBP2,&KAT2B,&IL2RA,&NF2,&TGFBR2,&CDK6,&PTPRU,&NCK2,&HDAC4,&ETS1,&TGFBR3,&PMP22,&SMARCA2,&SST

1.50

GOTERM_BP_FATGO:0051046~regulation&of&secretion 16 0.21 4.72E>02 PRKCA,&SERGEF,&PANX1,&PLA2G10,&PARK2,&ADORA1,&CPT1A,&CHD7,&CAPN10,&GRM8,&GRM7,&RAPGEF4,&PDE8B,&TRPV6,&FGF2,&PSMD9

1.71

GOTERM_BP_FATGO:0010558~negative&regulation&of&macromolecule&biosynthetic&process

35 0.45 4.72E>02 GLIS3,&FOXK1,&ENPP1,&GLIS1,&CTCF,&ZBTB16,&RBM9,&PRDM16,&NR2C1,&HOXA2,&MEIS2,&ATP8B1,&LRRFIP1,&NR2F2,&FGF2,&RUNX2,&MYST4,&ZNF423,&CIITA,&PRKCA,&CTBP1,&CTBP2,&KLF12,&NF2,&LMCD1,&NR0B2,&PTPRU,&FOXP1,&FOXN3,&ATXN1,&HDAC4,&SALL4,&PRDM6,&CUX1,&SMARCA2

1.38

GOTERM_BP_FATGO:0033993~response&to&lipid 4 0.05 4.76E>02 EGFR,&PNLIP,&TGFBR2,&TGFBR3 4.81GOTERM_BP_FATGO:0010464~regulation&of&

mesenchymal&cell&proliferation4 0.05 4.76E>02 TGFBR2,&PRRX1,&FOXP1,&BMPR1A 4.81

GOTERM_BP_FATGO:0048701~embryonic&cranial&skeleton&morphogenesis

4 0.05 4.76E>02 HOXA2,&CHST11,&TGFBR2,&PRRX1 4.81

GOTERM_BP_FATGO:0050954~sensory&perception&of&mechanical&stimulus

10 0.13 4.81E>02 ATP2B2,&SPRY2,&DFNA5,&CHD7,&FYN,&GRM7,&ITGA2,&COL1A1,&ATP6V0A4,&GPR98 2.10

GOTERM_MF_FATGO:0016564~transcription&repressor&activity

23 0.29 4.92E>02 CIITA,&CTBP1,&CTBP2,&KLF12,&FOXK1,&LMCD1,&CTCF,&NR0B2,&ZBTB16,&RBM9,&PRDM16,&FOXN3,&SUFU,&FOXP1,&NR2C1,&ATXN1,&HDAC4,&MEIS2,&LRRFIP1,&CUX1,&NR2F2,&MYST4,&ZNF423

1.52

GOTERM_MF_FATGO:0015631~tubulin&binding 10 0.13 4.93E>02 RAB11FIP5,&NDE1,&NUMA1,&NDEL1,&MACF1,&FYN,&MAP1B,&ARL8A,&ARL8B,&FEZ1 2.09GOTERM_BP_FATGO:0007016~cytoskeletal&anchoring&

at&plasma&membrane3 0.04 4.94E>02 TLN2,&ANK3,&FLNB 8.12

GOTERM_BP_FATGO:0030206~chondroitin&sulfate&biosynthetic&process

3 0.04 4.94E>02 CSGALNACT1,&SLC35D1,&CHST11 8.12

GOTERM_BP_FATGO:0009968~negative&regulation&of&signal&transduction

17 0.22 5.01E>02 PRKCA,&PRKCZ,&NF2,&ENPP1,&PRDM16,&AKT1,&RGS22,&ATXN1,&RGS12,&RGS3,&CHST11,&PPP2CB,&RGS5,&VWC2,&SMURF1,&AXIN2,&RUNX2

1.66

GOTERM_MF_FATGO:0008134~transcription&factor&binding

34 0.44 5.01E>02 GRIP1,&PRRX1,&CTCF,&TRRAP,&RBM9,&PRDM16,&SUFU,&MEIS2,&DIP2C,&MYOCD,&SMARCD3,&GATA6,&SND1,&NR2F2,&MYST4,&PSMD9,&HSD17B8,&CIITA,&CTBP1,&CTBP2,&KAT2B,&KLF12,&MAML2,&LMCD1,&NR0B2,&ARID1B,&ATXN7L3,&HDAC4,&PRICKLE1,&ETS1,&NFE2L1,&PBX1,&SMARCA2,&SLC9A1

1.39

GOTERM_BP_FATGO:0031401~positive&regulation&of&protein&modification&process

15 0.19 5.10E>02 PRKCA,&CSF2,&GDF7,&GDF6,&PRKAG2,&ADORA1,&HDAC4,&ATG7,&ANAPC7,&SMURF1,&MTOR,&FAM129A,&FGF2,&PSMD9,&BMPR1A

1.74

GOTERM_BP_FATGO:0030155~regulation&of&cell&adhesion

12 0.15 5.20E>02 PRKCZ,&CD36,&NF2,&CCDC80,&VWC2,&ITGA2,&CDK6,&COL1A1,&CX3CL1,&ADAM22,&SRC,&DPP4

1.90

GOTERM_CC_FATGO:0005625~soluble&fraction 22 0.28 5.22E>02 CYB5R2,&MAP1B,&PFKP,&ACACA,&MYO9B,&ACP1,&ANXA2,&CSGALNACT1,&AKT1,&PITPNM2,&BLMH,&FBLN1,&CTTN,&WISP1,&CLIC4,&PDE4B,&MTOR,&GRK5,&CORT,&ADCY10,&DPP4,&PC

1.53

GOTERM_BP_FATGO:0048661~positive&regulation&of&smooth&muscle&cell&proliferation

5 0.06 5.26E>02 PRKCA,&EGFR,&NOTCH4,&TGFBR2,&ITGA2 3.49

GOTERM_MF_FATGO:0004551~nucleotide&diphosphatase&activity

3 0.04 5.26E>02 FHIT,&ENPP1,&ENPP3 7.84

GOTERM_BP_FATGO:0001934~positive&regulation&of&protein&amino&acid&phosphorylation

9 0.12 5.27E>02 PRKCA,&CSF2,&GDF7,&GDF6,&PRKAG2,&MTOR,&FAM129A,&FGF2,&BMPR1A 2.19

GOTERM_BP_FATGO:0007160~cell>matrix&adhesion 9 0.12 5.27E>02 PARVG,&COL17A1,&SORBS1,&CD44,&PPFIA1,&PKD2,&ITGB5,&ITGA2,&PKD1 2.19GOTERM_MF_FATGO:0015298~solute:cation&antiporter&

activity5 0.06 5.28E>02 SLC9A9,&HIAT1,&TMCO3,&SLC9A11,&SLC9A1 3.48

GOTERM_BP_FATGO:0043434~response&to&peptide&hormone&stimulus

13 0.17 5.28E>02 PNLIP,&PRKCA,&PNLIPRP1,&KAT2B,&ENPP1,&BAIAP2,&MAP1B,&CDO1,&AKT1,&CAPN10,&SORBS1,&COL1A1,&MTOR

1.83

GOTERM_BP_FATGO:0046626~regulation&of&insulin&receptor&signaling&pathway

4 0.05 5.46E>02 PRKCA,&PRKCZ,&ENPP1,&SRC 4.56

GOTERM_BP_FATGO:0021545~cranial&nerve&development

4 0.05 5.46E>02 HOXB3,&CHD7,&HOXA3,&EPHB2 4.56

GOTERM_BP_FATGO:0051492~regulation&of&stress&fiber&formation


GOTERM_BP_FATGO:0042326~negative&regulation&of&phosphorylation

6 0.08 5.50E>02 PRKCA,&ATXN1,&PRKCZ,&NF2,&ENPP1,&FAM129A 2.89

GOTERM_BP_FATGO:0051495~positive&regulation&of&cytoskeleton&organization

6 0.08 5.50E>02 NCK2,&NF2,&MAP1B,&MTOR,&ARHGEF10L,&SYNPO 2.89

GOTERM_MF_FATGO:0005254~chloride&channel&activity 8 0.10 5.55E>02 CLCN3,&CLIC4,&ANO3,&PKD2,&ABCC4,&ANO2,&ANO4,&ANO6 2.32

GOTERM_BP_FATGO:0051247~positive&regulation&of&protein&metabolic&process

18 0.23 5.78E>02 PRKCA,&CSF2,&PLA2G10,&GDF7,&GDF6,&PRKAG2,&ITGA2,&ADORA1,&AKT1,&HDAC4,&ATG7,&ANAPC7,&SMURF1,&MTOR,&FAM129A,&FGF2,&PSMD9,&BMPR1A

1.60

GOTERM_BP_FATGO:0021954~central&nervous&system&neuron&development

5 0.06 5.80E>02 PRKCA,&PTK2,&NDEL1,&EPHB3,&EPHB2 3.38

GOTERM_BP_FATGO:0001933~negative&regulation&of&protein&amino&acid&phosphorylation

5 0.06 5.80E>02 PRKCA,&PRKCZ,&NF2,&ENPP1,&FAM129A 3.38

GOTERM_BP_FATGO:0002791~regulation&of&peptide&secretion

6 0.08 5.95E>02 CAPN10,&CHD7,&PDE8B,&ADORA1,&CPT1A,&PSMD9 2.82

GOTERM_BP_FATGO:0018108~peptidyl>tyrosine&phosphorylation

6 0.08 5.95E>02 FYN,&PDGFRA,&RELN,&ABL1,&SRC,&EPHB2 2.82

GOTERM_CC_FATGO:0032153~cell&division&site 3 0.04 6.10E>02 NF2,&ANLN,&MYH10 7.26GOTERM_CC_FATGO:0032155~cell&division&site&part 3 0.04 6.10E>02 NF2,&ANLN,&MYH10 7.26GOTERM_BP_FATGO:0040013~negative&regulation&of&

locomotion7 0.09 6.13E>02 NF2,&CLIC4,&TGFBR3,&PTPRU,&ADORA1,&FGF2,&VCL 2.48

GOTERM_BP_FATGO:0050808~synapse&organization 7 0.09 6.13E>02 DNM3,&ATP2B2,&MUSK,&SPOCK2,&ANK3,&MAP1B,&UTRN 2.48GOTERM_BP_FATGO:0050878~regulation&of&body&fluid&

levels12 0.15 6.15E>02 PLAT,&KCNMA1,&F10,&CD36,&HMCN1,&FLI1,&CD59,&TFPI,&NPR1,&ITGA2,&PROS1,&ANXA2 1.84

GOTERM_BP_FATGO:0060541~respiratory&system&development

10 0.13 6.16E>02 SPRY2,&FGF18,&CHD7,&GATA6,&TGFBR2,&PDGFRA,&CUX1,&FGF2,&FOXP1,&BMPR1A 2.00

GOTERM_BP_FATGO:0047496~vesicle&transport&along&microtubule

3 0.04 6.17E>02 PRKCZ,&NDE1,&NDEL1 7.21

GOTERM_BP_FATGO:0001954~positive&regulation&of&cell>matrix&adhesion

3 0.04 6.17E>02 PRKCZ,&CD36,&CDK6 7.21

GOTERM_BP_FATGO:0060349~bone&morphogenesis 4 0.05 6.21E>02 FGF18,&HSPG2,&COL1A1,&RUNX2 4.33GOTERM_MF_FATGO:0030247~polysaccharide&binding 13 0.17 6.50E>02 TNXB,&ENPP1,&ENPP3,&TGFBR2,&CCDC80,&COL5A1,&CD44,&NAV2,&LIPG,&TGFBR3,&

VCAN,&FGF2,&THBS21.76

GOTERM_MF_FATGO:0001871~pattern&binding 13 0.17 6.50E>02 TNXB,&ENPP1,&ENPP3,&TGFBR2,&CCDC80,&COL5A1,&CD44,&NAV2,&LIPG,&TGFBR3,&VCAN,&FGF2,&THBS2

1.76

GOTERM_MF_FATGO:0015399~primary&active&transmembrane&transporter&activity

11 0.14 6.67E>02 ATP2B2,&ATP2B4,&ATP8B1,&ATP6V1H,&ABCC4,&ATP11A,&ABCC1,&TIMM23,&ATP6V0A4,&ABCB4,&ABCC6

1.89

GOTERM_MF_FATGO:0015405~P>P>bond>hydrolysis>driven&transmembrane&transporter&activity

11 0.14 6.67E>02 ATP2B2,&ATP2B4,&ATP8B1,&ATP6V1H,&ABCC4,&ATP11A,&ABCC1,&TIMM23,&ATP6V0A4,&ABCB4,&ABCC6

1.89

GOTERM_MF_FATGO:0003712~transcription&cofactor&activity

25 0.32 6.70E>02 GRIP1,&PRRX1,&CTCF,&TRRAP,&RBM9,&PRDM16,&SUFU,&MEIS2,&MYOCD,&SMARCD3,&SND1,&NR2F2,&PSMD9,&HSD17B8,&CIITA,&CTBP2,&KAT2B,&KLF12,&MAML2,&LMCD1,&NR0B2,&ARID1B,&ATXN7L3,&NFE2L1,&SMARCA2

1.44

GOTERM_MF_FATGO:0046872~metal&ion&binding 216 2.77 6.86E>02 PDP1,&SLC9A9,&FHIT,&PLEKHM3,&PDLIM7,&LTBP2,&UTRN,&RNF216,&RORA,&TPD52,&ZNRF3,&ATP2B2,&CDH20,&HMCN1,&ATP2B4,&NT5C2,&GIT2,&SLC12A8,&RNF220,&OPA1,&F10,&RREB1,&TADA2B,&UBR4,&GEM,&MECOM,&SCEL,&PITPNM2,&PRDM6,&ENPP1,&ENPP3,&MYO9B,&PLAGL1,&MACF1,&GALNS,&CASZ1,&KLF12,&AGBL4,&TRPC7,&TGFBR2,&ACACA,&ZBTB40,&ATP11A,&OXSR1,&ZBTB44,&PXDNL,&RAPSN,&NOTCH4,&RHEB,&SYTL3,&RERE,&SLC9A1,&ARSB,&PXDN,&ARSG,&ZNFX1,&NUAK1,&KCNJ14,&ZBTB38,&USP19,&PARN,&SMAP1,&NEURL1B,&TRPV6,&NR2F2,&ADCY10,&KCNMA1,&RXFP1,&MICAL2,&ADNP,&GPR98,&ZCCHC14,&C4ORF23,&GRM7,&CHSY1,&VCAN,&ADAM12,&NKD1,&NKD2,&TRIM14,&ZBTB16,&GALNT10,&DGKD,&FMO2,&PPP2CB,&PKD2,&RASA3,&THBS2,&TES,&PLA2G10,&RBM20,&ZNF358,&AFP,&VAT1L,&CYP27C1,&FBLN1,&ADCY9,&FYN,&SVIL,&BNC1,&SH3RF3,&LRP2,&APOBEC2,&ZNF827,&NT5DC3,&GATA5,&GATA6,&MYST4,&CARS,&SCUBE2,&SPARCL1,&NEIL3,&CA12,&FBP2,&CDO1,&TRIM37,&NBR1,&RELN,&ZNF438,&SLC40A1,&ANKFY1,&FRAS1,&EFCAB8,&ADAMTSL3,&NR2C1,&PLCH1,&SCN9A,&HEG1,&TRAF5,&ZNF423,&SMG6,&LPP,&MRC2,&LMCD1,&ITGA2,&CACNA2D3,&TET1,&FOXP1,&SLC9A11,&EPS15,&ITGA9,&HDAC4,&TET3,&PDZD8,&SALL4,&PRICKLE1,&ITGA5,&FREM2,&ANTXR2,&ADAM22,&ABL1,&PC,&MAN1B1,&CTCF,&CBFA2T3,&ZFYVE21,&OSR1,&ATP8B1,&ANO3,&ANO2,&PDE8B,&LOXL3,&ANO4,&LOXL2,&ANO6,&LOXL1,&PRKCA,&ZNF280A,&PFKP,&GALNTL2,&PADI3,&DMRT1,&PRKCH,&GALNTL1,&MBNL1,&PRKCE,&DMRTB1,&PRKCB,&EML1,&SLC41A1,&LEPREL1,&CA1,&GALNT9,&PROS1,&WIZ,&ABLIM1,&GALNT2,&GLIS3,&ADAMTS17,&PRKCZ,&SPOCK2,&GLIS1,&MGMT,&BRSK2,&CDKAL1,&PRDM16,&CDH5,&TPM4,&SMOC2,&SCNM1,&FBN2,&RNF122,&ADARB2,&B3GALT2,&SLC12A4,&IDO2,&CREB5,&PARK2,&ATXN7L3,&ANXA2,&C9ORF3,&CADPS,&CSGALNACT1,&TSSK1B,&ARAP2,&BMPR1A

1.09

GOTERM_BP_FATGO:0018212~peptidyl>tyrosine&modification

6 0.08 6.90E>02 FYN,&PDGFRA,&RELN,&ABL1,&SRC,&EPHB2 2.71

GOTERM_BP_FATGO:0045936~negative&regulation&of&phosphate&metabolic&process


GOTERM_BP_FATGO:0010563~negative&regulation&of&phosphorus&metabolic&process


GOTERM_BP_FATGO:0051271~negative&regulation&of&cell&motion

7 0.09 6.96E>02 NF2,&CLIC4,&TGFBR3,&PTPRU,&ADORA1,&FGF2,&VCL 2.40

GOTERM_BP_FATGO:0006885~regulation&of&pH 5 0.06 6.97E>02 SLC9A9,&CLCN3,&ATP6V1H,&ATP6V0A4,&SLC9A1 3.18GOTERM_BP_FATGO:0050807~regulation&of&synapse&

organization4 0.05 7.01E>02 PRKCA,&MUSK,&PTK2,&CTNNA2 4.12

GOTERM_BP_FATGO:0018210~peptidyl>threonine&modification

4 0.05 7.01E>02 PRKCA,&GALNT2,&TGFBR2,&MTOR 4.12

GOTERM_BP_FATGO:0051017~actin&filament&bundle&formation

4 0.05 7.01E>02 SORBS1,&CALD1,&NEDD9,&GAS7 4.12

GOTERM_BP_FATGO:0043255~regulation&of&carbohydrate&biosynthetic&process


GOTERM_BP_FATGO:0032231~regulation&of&actin&filament&bundle&formation


GOTERM_CC_FATGO:0048471~perinuclear&region&of&cytoplasm

20 0.26 7.13E>02 KCNMA1,&TG,&DNM3,&GALNT2,&PRKCZ,&NF2,&ENPP3,&MRVI1,&MAP1B,&LMNA,&ITGA2,&MYO9B,&TPD52L1,&PARK2,&TPD52,&ANXA2,&TRIM37,&ARF3,&ADCY10,&RAP1GAP2

1.51

GOTERM_CC_FATGO:0030425~dendrite 13 0.17 7.16E>02 DNM3,&OPA1,&CALD1,&MAP1B,&ADORA1,&ATP2B2,&NUMA1,&P2RX6,&GRM7,&RELN,&MTOR,&SYNPO,&MYH10

1.74

GOTERM_MF_FATGO:0005516~calmodulin&binding 12 0.15 7.17E>02 ATP2B2,&CAMTA1,&ATP2B4,&MYO1B,&CALD1,&UBR4,&IQGAP2,&CAMK1,&MYO9B,&TRPV6,&GEM,&MYH10

1.79

GOTERM_BP_FATGO:0019933~cAMP>mediated&signaling

9 0.12 7.17E>02 RXFP1,&ADCY9,&PDE7A,&RAPGEF4,&GLP2R,&GRK5,&CORT,&ADCY10,&ADORA1 2.05

GOTERM_MF_FATGO:0030165~PDZ&domain&binding 6 0.08 7.22E>02 ATP2B2,&CLCN3,&GRM7,&TGFBR3,&SLC9A3R1,&DOCK4 2.67GOTERM_BP_FATGO:0001764~neuron&migration 7 0.09 7.40E>02 NDE1,&PTK2,&NDEL1,&FYN,&RELN,&NR2F2,&MYH10 2.37GOTERM_CC_FATGO:0005614~interstitial&matrix 3 0.04 7.40E>02 NAV2,&CCDC80,&VWC2 6.53GOTERM_MF_FATGO:0031404~chloride&ion&binding 8 0.10 7.43E>02 CLCN3,&SLC12A8,&CLIC4,&ANO3,&NPR1,&ANO2,&ANO4,&ANO6 2.17GOTERM_CC_FATGO:0005581~collagen 5 0.06 7.46E>02 TNXB,&COL4A1,&COL27A1,&COL1A1,&COL5A1 3.11GOTERM_BP_FATGO:0051647~nucleus&localization 3 0.04 7.48E>02 PTK2,&MYH10,&TACC2 6.49GOTERM_BP_FATGO:0031103~axon&regeneration 3 0.04 7.48E>02 RTN4RL1,&MAP1B,&VCAN 6.49GOTERM_BP_FATGO:0042953~lipoprotein&transport 3 0.04 7.48E>02 CD36,&LRP2,&PRKCB 6.49GOTERM_BP_FATGO:0021680~cerebellar&Purkinje&cell&

layer&development3 0.04 7.48E>02 ATP2B2,&RORA,&MYH10 6.49

GOTERM_BP_FATGO:0045596~negative&regulation&of&cell&differentiation

16 0.21 7.50E>02 ENPP1,&CDK6,&ZBTB16,&PRDM16,&ZNF358,&GPR98,&EPHB2,&HDAC4,&PTK2,&HOXA2,&PRDM6,&NOTCH4,&TGFBR3,&PBX1,&AXIN2,&BMPR1A

1.60

GOTERM_MF_FATGO:0042626~ATPase&activity,&coupled&to&transmembrane&movement&of&substances

10 0.13 7.64E>02 ATP2B2,&ATP2B4,&ATP8B1,&ATP6V1H,&ABCC4,&ATP11A,&ABCC1,&ATP6V0A4,&ABCB4,&ABCC6

1.92

GOTERM_CC_FATGO:0005576~extracellular&region 106 1.36 7.73E>02 FGF18,&LTBP2,&GDF7,&GDF6,&DEFB106B,&VCL,&ST3GAL1,&ST3GAL3,&OLFML3,&HMCN1,&CD44,&CDNF,&PDGFD,&SPON1,&EGFR,&F10,&SPARCL1,&OLFML2B,&CRTAP,&IL21,&NAV2,&PDGFRL,&TFPI,&RELN,&COL1A1,&FAM172A,&FRAS1,&HDLBP,&ENPP1,&ADAMTSL3,&ENPP3,&ESM1,&CX3CL1,&LEAP2,&EPHB6,&HEG1,&PLAT,&CCDC80,&MUC6,&PXDNL,&SFRP1,&FREM2,&CD59,&SFRP4,&NOTCH4,&THSD4,&TGFBR3,&IGFL2,&ANTXR2,&ADAM22,&IL5RA,&CORT,&PDZD2,&SST,&IL22RA2,&APOL5,&PNLIP,&PXDN,&CD8A,&IGFBP7,&SORL1,&WISP1,&SEMA3E,&LOXL3,&LOXL2,&FGF2,&LOXL1,&NRG2,&DPP4,&ADNP,&PLXDC1,&VCAN,&ADAM12,&PROS1,&TG,&CSF2,&ADAMTS17,&GALNT2,&TNFRSF25,&SPOCK2,&C2ORF88,&NETO1,&C1QTNF7,&SMOC2,&C1QTNF8,&COL17A1,&COL27A1,&VWC2,&FBN2,&THBS2,&DPT,&PNLIPRP1,&TNXB,&COL4A1,&PLA2G10,&HSPG2,&COL5A1,&HPR,&WNT2B,&ANXA2,&AFP,&FBLN1,&FAM180A,&LIPG,&GDF10,&LRP2

1.15

GOTERM_MF_FATGO:0005253~anion&channel&activity 8 0.10 7.84E>02 CLCN3,&CLIC4,&ANO3,&PKD2,&ABCC4,&ANO2,&ANO4,&ANO6 2.14GOTERM_BP_FATGO:0046326~positive&regulation&of&

glucose&import4 0.05 7.85E>02 AKT1,&PRKCZ,&CAPN10,&SORBS1 3.94

GOTERM_BP_FATGO:0010828~positive&regulation&of&glucose&transport

4 0.05 7.85E>02 AKT1,&PRKCZ,&CAPN10,&SORBS1 3.94

GOTERM_BP_FATGO:0035136~forelimb&morphogenesis 4 0.05 7.85E>02 HOXA9,&ZBTB16,&MECOM,&ZNF358 3.94

GOTERM_BP_FATGO:0009582~detection&of&abiotic&stimulus

7 0.09 7.85E>02 ATP2B2,&PDE6B,&FYN,&PKD2,&ITGA2,&PKD1,&GPR98 2.33

GOTERM_BP_FATGO:0042063~gliogenesis 7 0.09 7.85E>02 EGFR,&NF2,&PDGFRA,&CDK6,&VCAN,&RELN,&FGF2 2.33GOTERM_MF_FATGO:0050431~transforming&growth&

factor&beta&binding3 0.04 7.95E>02 CD36,&TGFBR2,&TGFBR3 6.27

GOTERM_MF_FATGO:0043492~ATPase&activity,&coupled&to&movement&of&substances


1.90

GOTERM_MF_FATGO:0043169~cation&binding 217 2.78 8.09E>02 PDP1,&SLC9A9,&FHIT,&PLEKHM3,&PDLIM7,&LTBP2,&UTRN,&RNF216,&RORA,&TPD52,&ZNRF3,&ATP2B2,&CDH20,&HMCN1,&ATP2B4,&NT5C2,&GIT2,&SLC12A8,&RNF220,&OPA1,&F10,&RREB1,&TADA2B,&UBR4,&GEM,&MECOM,&SCEL,&PITPNM2,&PRDM6,&ENPP1,&ENPP3,&MYO9B,&PLAGL1,&MACF1,&GALNS,&CASZ1,&KLF12,&AGBL4,&TRPC7,&TGFBR2,&ACACA,&ZBTB40,&ATP11A,&OXSR1,&ZBTB44,&PXDNL,&GBE1,&RAPSN,&NOTCH4,&RHEB,&SYTL3,&RERE,&SLC9A1,&ARSB,&PXDN,&ARSG,&ZNFX1,&NUAK1,&KCNJ14,&ZBTB38,&USP19,&PARN,&SMAP1,&NEURL1B,&TRPV6,&NR2F2,&ADCY10,&KCNMA1,&RXFP1,&MICAL2,&ADNP,&GPR98,&ZCCHC14,&C4ORF23,&GRM7,&CHSY1,&VCAN,&ADAM12,&NKD1,&NKD2,&TRIM14,&ZBTB16,&GALNT10,&DGKD,&FMO2,&PPP2CB,&PKD2,&RASA3,&THBS2,&TES,&PLA2G10,&RBM20,&ZNF358,&AFP,&VAT1L,&CYP27C1,&FBLN1,&ADCY9,&FYN,&SVIL,&BNC1,&SH3RF3,&LRP2,&APOBEC2,&ZNF827,&NT5DC3,&GATA5,&GATA6,&MYST4,&CARS,&SCUBE2,&SPARCL1,&NEIL3,&CA12,&FBP2,&CDO1,&TRIM37,&NBR1,&RELN,&ZNF438,&SLC40A1,&ANKFY1,&FRAS1,&EFCAB8,&ADAMTSL3,&NR2C1,&PLCH1,&SCN9A,&HEG1,&TRAF5,&ZNF423,&SMG6,&LPP,&MRC2,&LMCD1,&ITGA2,&CACNA2D3,&TET1,&FOXP1,&SLC9A11,&EPS15,&ITGA9,&HDAC4,&TET3,&PDZD8,&SALL4,&PRICKLE1,&ITGA5,&FREM2,&ANTXR2,&ADAM22,&ABL1,&PC,&MAN1B1,&CTCF,&CBFA2T3,&ZFYVE21,&OSR1,&ATP8B1,&ANO3,&ANO2,&PDE8B,&LOXL3,&ANO4,&LOXL2,&ANO6,&LOXL1,&PRKCA,&ZNF280A,&PFKP,&GALNTL2,&PADI3,&DMRT1,&PRKCH,&GALNTL1,&MBNL1,&PRKCE,&DMRTB1,&PRKCB,&EML1,&SLC41A1,&LEPREL1,&CA1,&GALNT9,&PROS1,&WIZ,&ABLIM1,&GALNT2,&GLIS3,&ADAMTS17,&PRKCZ,&SPOCK2,&GLIS1,&MGMT,&BRSK2,&CDKAL1,&PRDM16,&CDH5,&TPM4,&SMOC2,&SCNM1,&FBN2,&RNF122,&ADARB2,&B3GALT2,&SLC12A4,&IDO2,&CREB5,&PARK2,&ATXN7L3,&ANXA2,&C9ORF3,&CADPS,&CSGALNACT1,&TSSK1B,&ARAP2,&BMPR1A

1.09

GOTERM_BP_FATGO:0022604~regulation&of&cell&morphogenesis

11 0.14 8.10E>02 NTRK3,&PTK2,&SHROOM3,&NDEL1,&FYN,&MAP1B,&FERMT2,&TGFBR3,&GAS7,&MYH10,&EPHB2

1.82

GOTERM_MF_FATGO:0043167~ion&binding 220 2.82 8.11E>02 PDP1,&SLC9A9,&FHIT,&PLEKHM3,&PDLIM7,&LTBP2,&UTRN,&RNF216,&RORA,&TPD52,&ZNRF3,&ATP2B2,&CDH20,&ATP2B4,&HMCN1,&NT5C2,&GIT2,&SLC12A8,&RNF220,&OPA1,&F10,&RREB1,&TADA2B,&UBR4,&GEM,&MECOM,&SCEL,&PITPNM2,&PRDM6,&CLCN3,&ENPP1,&ENPP3,&MYO9B,&PLAGL1,&MACF1,&GALNS,&CASZ1,&KLF12,&AGBL4,&TRPC7,&TGFBR2,&ACACA,&ZBTB40,&ATP11A,&OXSR1,&ZBTB44,&PXDNL,&GBE1,&RAPSN,&NOTCH4,&RHEB,&SYTL3,&RERE,&SLC9A1,&ARSB,&PXDN,&ARSG,&ZNFX1,&NUAK1,&KCNJ14,&ZBTB38,&USP19,&PARN,&SMAP1,&NEURL1B,&TRPV6,&NR2F2,&ADCY10,&KCNMA1,&RXFP1,&MICAL2,&ADNP,&GPR98,&ZCCHC14,&C4ORF23,&CLIC4,&GRM7,&CHSY1,&VCAN,&ADAM12,&NKD1,&NKD2,&TRIM14,&ZBTB16,&GALNT10,&DGKD,&FMO2,&PPP2CB,&PKD2,&RASA3,&THBS2,&TES,&PLA2G10,&RBM20,&NPR1,&ZNF358,&AFP,&VAT1L,&CYP27C1,&FBLN1,&ADCY9,&FYN,&SVIL,&BNC1,&SH3RF3,&LRP2,&APOBEC2,&ZNF827,&NT5DC3,&GATA5,&GATA6,&MYST4,&CARS,&SCUBE2,&SPARCL1,&NEIL3,&CA12,&FBP2,&CDO1,&TRIM37,&NBR1,&RELN,&ZNF438,&SLC40A1,&ANKFY1,&FRAS1,&EFCAB8,&ADAMTSL3,&NR2C1,&PLCH1,&SCN9A,&HEG1,&TRAF5,&ZNF423,&SMG6,&LPP,&MRC2,&LMCD1,&ITGA2,&CACNA2D3,&TET1,&FOXP1,&SLC9A11,&EPS15,&HDAC4,&ITGA9,&TET3,&PDZD8,&SALL4,&PRICKLE1,&ITGA5,&FREM2,&ANTXR2,&ADAM22,&ABL1,&PC,&MAN1B1,&CTCF,&CBFA2T3,&ZFYVE21,&OSR1,&ATP8B1,&ANO3,&ANO2,&PDE8B,&LOXL3,&ANO4,&LOXL2,&ANO6,&LOXL1,&PRKCA,&ZNF280A,&PFKP,&GALNTL2,&PADI3,&DMRT1,&PRKCH,&GALNTL1,&MBNL1,&PRKCE,&DMRTB1,&PRKCB,&EML1,&SLC41A1,&LEPREL1,&CA1,&GALNT9,&PROS1,&WIZ,&ABLIM1,&GALNT2,&GLIS3,&ADAMTS17,&PRKCZ,&SPOCK2,&GLIS1,&MGMT,&BRSK2,&CDKAL1,&PRDM16,&CDH5,&TPM4,&SMOC2,&SCNM1,&FBN2,&RNF122,&ADARB2,&B3GALT2,&SLC12A4,&IDO2,&CREB5,&PARK2,&ATXN7L3,&ANXA2,&C9ORF3,&CADPS,&CSGALNACT1,&TSSK1B,&ARAP2,&BMPR1A

1.08

GOTERM_BP_FATGO:0031589~cell>substrate&adhesion 9 0.12 8.26E>02 PARVG,&COL17A1,&SORBS1,&CD44,&PPFIA1,&PKD2,&ITGB5,&ITGA2,&PKD1 1.99GOTERM_BP_FATGO:0009123~nucleoside&

monophosphate&metabolic&process7 0.09 8.31E>02 ATP2B2,&ADCY9,&NPR1,&PDE8B,&RORA,&ADCY10,&AMPD1 2.30

GOTERM_MF_FATGO:0030246~carbohydrate&binding 24 0.31 8.32E>02 GALNT2,&TNXB,&NOMO3,&ENPP1,&ENPP3,&MRC2,&EPM2A,&TGFBR2,&GALNTL2,&PFKP,&CCDC80,&GALNTL1,&COL5A1,&GALNT10,&CD44,&NAV2,&IGF2R,&LIPG,&PKD1,&TGFBR3,&VCAN,&THBS2,&FGF2,&GALNT9

1.42

GOTERM_MF_FATGO:0016820~hydrolase&activity,&acting&on&acid&anhydrides,&catalyzing&transmembrane&movement&of&substances


1.88

GOTERM_BP_FATGO:0001503~ossification 10 0.13 8.40E>02 EGFR,&FGF18,&HOXA2,&PDLIM7,&HSPG2,&COL1A1,&AXIN2,&EXT1,&ATP6V0A4,&RUNX2 1.88GOTERM_BP_FATGO:0008202~steroid&metabolic&

process15 0.19 8.44E>02 SOAT1,&HDLBP,&CYB5R2,&PRKAG2,&SORL1,&NR0B2,&SCARF1,&ACOX3,&AFP,&ATP8B1,&

OSBPL10,&PBX1,&FGF2,&HSD17B7,&HSD17B81.61

GOTERM_BP_FATGO:0035295~tube&development 16 0.21 8.47E>02 FGF18,&SHROOM3,&TGFBR2,&FOXP1,&LGR4,&SEMA5A,&RGMA,&SPRY2,&CD44,&GATA6,&NOTCH4,&PDGFRA,&PBX1,&CUX1,&FGF2,&BMPR1A

1.57

GOTERM_MF_FATGO:0015020~glucuronosyltransferase&activity

4 0.05 8.51E>02 CSGALNACT1,&CHSY1,&EXT1,&UGT2B7 3.80

GOTERM_CC_FATGO:0043025~cell&soma 13 0.17 8.53E>02 CALD1,&MAP1B,&ADORA1,&EPHB2,&ALCAM,&ATP2B2,&NUMA1,&P2RX6,&GRM8,&MTOR,&SST,&SYNPO,&MYH10

1.68

GOTERM_BP_FATGO:0030324~lung&development 9 0.12 8.65E>02 SPRY2,&FGF18,&GATA6,&TGFBR2,&PDGFRA,&CUX1,&FGF2,&FOXP1,&BMPR1A 1.97GOTERM_MF_FATGO:0032403~protein&complex&binding 15 0.19 8.66E>02 PDP1,&CIITA,&TNXB,&ENPP1,&MAP1B,&ITGA2,&ADORA1,&COL5A1,&RPTOR,&SORBS1,&

CLIC4,&ITGA5,&ADAM22,&SMURF1,&FRS21.60

GOTERM_BP_FATGO:0030004~cellular&monovalent&inorganic&cation&homeostasis

4 0.05 8.73E>02 KCNMA1,&CLCN3,&ATP6V1H,&NEDD4L 3.76

GOTERM_BP_FATGO:0048806~genitalia&development 4 0.05 8.73E>02 CHD7,&TEX15,&PDGFRA,&LGR4 3.76GOTERM_CC_FATGO:0031902~late&endosome&

membrane3 0.04 8.78E>02 SLC9A9,&ARL8A,&ARL8B 5.94

GOTERM_BP_FATGO:0050650~chondroitin&sulfate&proteoglycan&biosynthetic&process

3 0.04 8.87E>02 CSGALNACT1,&SLC35D1,&CHST11 5.90

GOTERM_BP_FATGO:0060324~face&development 3 0.04 8.87E>02 CHD7,&PDGFRA,&COL1A1 5.90GOTERM_BP_FATGO:0021602~cranial&nerve&

morphogenesis3 0.04 8.87E>02 HOXB3,&HOXA3,&EPHB2 5.90

GOTERM_CC_FATGO:0048787~presynaptic&active&zone&membrane

2 0.03 8.96E>02 KCNMA1,&GRM7 21.78

GOTERM_CC_FATGO:0002133~polycystin&complex 2 0.03 8.96E>02 PKD2,&PKD1 21.78GOTERM_BP_FATGO:0030505~inorganic&diphosphate&

transport2 0.03 9.01E>02 ENPP1,&ENPP3 21.64

GOTERM_BP_FATGO:0045944~positive&regulation&of&transcription&from&RNA&polymerase&II&promoter

24 0.31 9.08E>02 CIITA,&GLIS3,&KLF12,&MAML2,&GLIS1,&TEAD1,&RORA,&MECOM,&ZBTB38,&ATXN1,&PLAGL1,&HDAC4,&HOXA2,&NPAS2,&MEIS2,&SALL4,&MYOCD,&GATA6,&ETS1,&PBX1,&FGF2,&SMARCA2,&RUNX2,&ARHGEF10L

1.40

GOTERM_BP_FATGO:0030334~regulation&of&cell&migration

13 0.17 9.13E>02 EGFR,&F10,&NF2,&ITGA2,&PTPRU,&ADORA1,&VCL,&AKT1,&CLIC4,&PDGFRA,&TGFBR3,&FGF2,&SST

1.66

GOTERM_CC_FATGO:0045211~postsynaptic&membrane 11 0.14 9.15E>02 PRR7,&KCNMA1,&GRIP1,&RAPSN,&GRM7,&UTRN,&TANC1,&ADORA1,&SHANK2,&DLG2,&SYNPO

1.77

GOTERM_MF_FATGO:0001642~group&III&metabotropic&glutamate&receptor&activity

2 0.03 9.32E>02 GRM8,&GRM7 20.91

GOTERM_MF_FATGO:0003943~N>acetylgalactosamine>4>sulfatase&activity

2 0.03 9.32E>02 ARSB,&GALNS 20.91

GOTERM_MF_FATGO:0043014~alpha>tubulin&binding 3 0.04 9.41E>02 NDEL1,&ARL8A,&ARL8B 5.70GOTERM_BP_FATGO:0048732~gland&development 11 0.14 9.43E>02 EGFR,&HOXB3,&ATP2B2,&HOXA3,&SFRP1,&RXFP1,&NOTCH4,&HOXA9,&ITGA2,&PBX1,&

CDO11.76

GOTERM_BP_FATGO:0051051~negative&regulation&of&transport

11 0.14 9.43E>02 PRKCA,&AKT1,&SERGEF,&ENPP1,&WWP2,&GRM7,&PKD2,&PDE8B,&NEDD4L,&ADORA1,&PSMD9

1.76

GOTERM_CC_FATGO:0043197~dendritic&spine 5 0.06 9.47E>02 DNM3,&P2RX6,&CALD1,&MYH10,&SYNPO 2.87GOTERM_CC_FATGO:0005615~extracellular&space 40 0.51 9.47E>02 PNLIP,&TG,&CSF2,&FGF18,&HDLBP,&ENPP1,&GDF7,&GDF6,&IGFBP7,&SORL1,&CX3CL1,&

C1QTNF7,&SEMA3E,&VWC2,&LOXL3,&LOXL2,&LOXL1,&FGF2,&EGFR,&PLAT,&PNLIPRP1,&TNXB,&ADNP,&IL21,&HPR,&WNT2B,&AFP,&FBLN1,&SFRP1,&NOTCH4,&SFRP4,&LIPG,&TFPI,&GDF10,&TGFBR3,&RELN,&IL5RA,&LRP2,&SST,&IL22RA2

1.27

GOTERM_BP_FATGO:0009199~ribonucleoside&triphosphate&metabolic&process

10 0.13 9.49E>02 ATP2B2,&ATP2B4,&CTPS,&PRKAG2,&ATP8B1,&ATP6V1H,&ATP11A,&MYO9B,&ATP6V0A4,&ABCC6

1.83

GOTERM_CC_FATGO:0001725~stress&fiber 4 0.05 9.51E>02 PDLIM7,&SORBS1,&FERMT2,&MYH10 3.63GOTERM_BP_FATGO:0006898~receptor>mediated&

endocytosis6 0.08 9.64E>02 PDLIM7,&IGF2R,&SORL1,&TGFBR2,&LRP2,&SCARF1 2.45

GOTERM_BP_FATGO:0050803~regulation&of&synapse&structure&and&activity

4 0.05 9.65E>02 PRKCA,&MUSK,&PTK2,&CTNNA2 3.61

GOTERM_BP_FATGO:0009143~nucleoside&triphosphate&catabolic&process

4 0.05 9.65E>02 ENPP1,&ENPP3,&MYO9B,&ABCC6 3.61

GOTERM_BP_FATGO:0046777~protein&amino&acid&autophosphorylation

8 0.10 9.70E>02 EGFR,&NTRK3,&AKT1,&PTK2,&VRK2,&FYN,&PDGFRA,&MTOR 2.04

GOTERM_BP_FATGO:0030323~respiratory&tube&development

9 0.12 9.86E>02 SPRY2,&FGF18,&GATA6,&TGFBR2,&PDGFRA,&CUX1,&FGF2,&FOXP1,&BMPR1A 1.91

GOTERM_BP_FATGO:0014706~striated&muscle&tissue&development

10 0.13 9.87E>02 MUSK,&GATA6,&SVIL,&UTRN,&HSPG2,&TGFBR3,&MBNL1,&NR2F2,&FOXP1,&MYH10 1.82

PathwaysCategory Term Count % Fisher&exact&p>

valueGenes Fold&

EnrichmentBIOCARTA h_agrPathway:Agrin&in&Postsynaptic&

Differentiation9 0.12 8.72E>05 EGFR,&CTTN,&MUSK,&PTK2,&RAPSN,&UTRN,&GIT2,&NRG2,&SRC 5.64

KEGG_PATHWAY

hsa04512:ECM>receptor&interaction 15 0.19 1.12E>04 COL4A1,&TNXB,&HSPG2,&ITGA2,&ITGB5,&COL5A1,&ITGA9,&CD36,&CD44,&ITGA5,&RELN,&SV2B,&SV2A,&COL1A1,&THBS2

3.35

KEGG_PATHWAY

hsa04510:Focal&adhesion 25 0.32 1.34E>04 TLN2,&ITGB5,&SRC,&VCL,&AKT1,&PTK2,&PDGFD,&THBS2,&EGFR,&PRKCA,&PARVG,&COL4A1,&TNXB,&ITGA2,&FLNC,&FLNB,&COL5A1,&PRKCB,&ITGA9,&ITGA5,&RASGRF1,&FYN,&PDGFRA,&RELN,&COL1A1

2.33

KEGG_PATHWAY

hsa00512:O>Glycan&biosynthesis 7 0.09 4.27E>03 ST3GAL1,&GALNT2,&GCNT3,&GALNT10,&GALNTL2,&GALNTL1,&GALNT9 4.38

KEGG_PATHWAY

hsa04530:Tight&junction 16 0.21 4.61E>03 PRKCA,&PRKCZ,&CNKSR3,&PRKCH,&PRKCE,&CTNNA3,&SRC,&LLGL2,&CTNNA2,&PRKCB,&AKT1,&EPB41L2,&CTTN,&PPP2CB,&JAM3,&MYH10

2.24

BIOCARTA h_achPathway:Role&of&nicotinic&acetylcholine&receptors&in&the&regulation&of&apoptosis

5 0.06 6.93E>03 AKT1,&MUSK,&PTK2,&RAPSN,&SRC 6.04

KEGG_PATHWAY

hsa04360:Axon&guidance 15 0.19 8.02E>03 ABLIM1,&NGEF,&EFNB2,&EPHB3,&EPHB2,&SEMA5A,&SEMA6A,&SEMA5B,&NCK2,&PTK2,&EPHB6,&RGS3,&FYN,&SEMA3E,&ABL1

2.18

KEGG_PATHWAY

hsa04520:Adherens&junction 10 0.13 1.99E>02 EGFR,&SORBS1,&FYN,&BAIAP2,&TGFBR2,&ACP1,&SRC,&CTNNA3,&VCL,&CTNNA2 2.44

BIOCARTA h_cblPathway:CBL&mediated&ligand>induced&downregulation&of&EGF&receptors

4 0.05 2.26E>02 PRKCA,&EGFR,&PDGFRA,&SRC 6.15

KEGG_PATHWAY

hsa04144:Endocytosis 17 0.22 3.41E>02 EGFR,&DNM3,&PRKCZ,&IL2RA,&TGFBR2,&SRC,&EPS15,&RAB11FIP5,&SMAP1,&SH3GLB2,&PDGFRA,&GIT2,&NEDD4L,&GRK5,&SMURF1,&ARAP2,&EPN1

1.73

KEGG_PATHWAY

hsa04270:Vascular&smooth&muscle&contraction

12 0.15 3.45E>02 PRKCA,&KCNMA1,&PLA2G10,&ADCY9,&PPP1R12B,&CALD1,&MRVI1,&PLA2G6,&NPR1,&PRKCH,&PRKCE,&PRKCB

2.01

KEGG_PATHWAY

hsa04810:Regulation&of&actin&cytoskeleton

19 0.24 3.56E>02 EGFR,&FGF18,&BAIAP2,&SSH2,&IQGAP2,&ITGA2,&ITGB5,&GNG12,&VCL,&ITGA9,&PTK2,&PFN4,&ITGA5,&PDGFRA,&PDGFD,&PIP4K2A,&FGF2,&MYH10,&SLC9A1

1.66

BIOCARTA h_amiPathway:Acute&Myocardial&Infarction

4 0.05 3.60E>02 PLAT,&F10,&TFPI,&PROS1 5.20

KEGG_PATHWAY

hsa04012:ErbB&signaling&pathway 10 0.13 4.00E>02 PRKCA,&EGFR,&AKT1,&NCK2,&PTK2,&MTOR,&ABL1,&NRG2,&SRC,&PRKCB 2.16

KEGG_PATHWAY

hsa05200:Pathways&in&cancer 26 0.33 4.04E>02 FGF18,&ZBTB16,&SUFU,&AKT1,&PTK2,&AXIN2,&FGF2,&TRAF5,&PRKCA,&EGFR,&CTBP1,&CTBP2,&COL4A1,&TGFBR2,&ITGA2,&CDK6,&MECOM,&CTNNA3,&WNT2B,&CTNNA2,&PRKCB,&ETS1,&PDGFRA,&MTOR,&IKBKB,&ABL1

1.49

BIOCARTA h_edg1Pathway:Phospholipids&as&signalling&intermediaries

5 0.06 4.10E>02 PRKCA,&AKT1,&PTK2,&PDGFRA,&SRC 3.68

KEGG_PATHWAY

hsa05220:Chronic&myeloid&leukemia 9 0.12 4.40E>02 AKT1,&CTBP1,&CTBP2,&GAB2,&TGFBR2,&CDK6,&IKBKB,&ABL1,&MECOM 2.25

BIOCARTA h_integrinPathway:Integrin&Signaling&Pathway

6 0.08 4.41E>02 PTK2,&TNS1,&FYN,&PPP1R12B,&SRC,&VCL 2.98

KEGG_PATHWAY

hsa04664:Fc&epsilon&RI&signaling&pathway

9 0.12 5.35E>02 PRKCA,&AKT1,&CSF2,&GAB2,&PLA2G10,&FYN,&PLA2G6,&PRKCE,&PRKCB 2.17

KEGG_PATHWAY

hsa04310:Wnt&signaling&pathway 14 0.18 5.66E>02 PRKCA,&CTBP1,&NKD1,&NKD2,&CTBP2,&DAAM1,&DAAM2,&WNT2B,&PRKCB,&SFRP1,&PRICKLE1,&SFRP4,&PPP2CB,&AXIN2

1.74

KEGG_PATHWAY

hsa00592:alpha>Linolenic&acid&metabolism

4 0.05 6.69E>02 ACOX1,&PLA2G10,&PLA2G6,&ACOX3 4.17

BIOCARTA h_At1rPathway:Angiotensin&II&mediated&activation&of&JNK&Pathway&via&Pyk2&dependent&signaling

5 0.06 6.82E>02 PRKCA,&EGFR,&PTK2,&CAMK1,&SRC 3.13

KEGG_PATHWAY

hsa04640:Hematopoietic&cell&lineage 9 0.12 8.47E>02 CSF2,&CD36,&IL2RA,&CD8A,&CD44,&ITGA5,&CD59,&ITGA2,&IL5RA 1.96

BIOCARTA h_ndkDynaminPathway:Endocytotic&role&of&NDK,&Phosphins&and&Dynamin

3 0.04 9.30E>02 EPS15,&CAMK1,&EPN1 5.64

BIOCARTA h_srcRPTPPathway:Activation&of&Src&by&Protein>tyrosine&phosphatase&alpha

3 0.04 9.30E>02 PRKCA,&RASGRF1,&SRC 5.64

Tissue&specificity

Category Term Count % Fisher&exact&p>value

Genes Fold&Enrichment

UP_TISSUE Brain 438 5.62 6.84E>11 FHIT,&KIAA0556,&AGXT2L1,&BTBD1,&BAHCC1,&R3HCC1,&OPA1,&RREB1,&TADA2B,&PTPRU,&ERGIC1,&CTNNA3,&RPTOR,&TMEM132D,&CTNNA2,&PITPNM2,&TRAPPC9,&ROR1,&ARL8A,&CMIP,&ARL8B,&MYO18A,&SORCS1,&FAM19A2,&DAAM1,&DAAM2,&ACP1,&SORCS2,&ALCAM,&ARHGEF10L,&SFRS12,&PHYHIPL,&KLF12,&EPM2A,&ACACA,&CCDC80,&C3ORF26,&ATP11A,&UBE2L3,&GAS7,&RGS3,&ARF3,&RGS5,&ARF4,&MAP4,&TGFBR3,&SMURF1,&ACAD10,&RERE,&BTBD11,&GFAP,&BACH2,&NUAK1,&ZNFX1,&FAM168B,&USP19,&SMAP1,&TMEM108,&PWWP2A,&TICAM1,&KIAA0895,&PARVG,&FMNL2,&SH3PXD2A,&MICAL2,&PIK3C2B,&TLE3,&ADNP,&SDK1,&TLE4,&ARHGEF10,&GPR98,&EPB41L2,&FMN1,&VCAN,&KIAA1217,&CHSY1,&GNB3,&GRAMD1B,&SMTNL2,&EPB41L4B,&GNG12,&KIAA1737,&C2ORF84,&NUMA1,&PLEKHG1,&GALNT10,&SORBS1,&DGKD,&PKD2,&TBC1D5,&PKD1,&RASA3,&HSD17B8,&DNM3,&FLJ35220,&SELT,&PKNOX2,&VAT1L,&SH3RF3,&MAT2B,&WDR20,&CTNNAL1,&KIAA1324,&IQGAP2,&CNOT1,&RBM9,&VCL,&NUDCD3,&ST3GAL3,&ANK3,&SND1,&ATG7,&PDE4B,&PITPNC1,&STK39,&FBXO21,&SPON1,&EGFR,&BEND6,&STK24,&BAIAP2,&PTPRN2,&PISD,&ARID1B,&CDO1,&RNASEH2B,&TACC2,&RASGRF1,&COL1A1,&PTGFRN,&SMARCA2,&CAMTA1,&ADAMTSL3,&SETD1B,&MAPKAPK5,&CNTFR,&CX3CL1,&PTK2,&MEIS2,&TEF,&SLC35F3,&ZNF423,&PHACTR1,&PHACTR2,&RAB8A,&NOMO3,&SMG6,&NIN,&MYO1B,&MRC2,&DOCK9,&MTHFSD,&DOCK5,&CACNA2D3,&SHANK2,&DOCK4,&HDAC4,&MYO10,&ST7L,&P2RX6,&R3HDM2,&ADAM22,&ABL1,&IKBKB,&PDZD2,&MYH10,&CYB5R2,&ACOT2,&MAN1B1,&CTCF,&ZFYVE21,&CCRL2,&SH2D4B,&SPRY2,&ACOT7,&GLT25D2,&SLC35D1,&PDE8B,&ANO4,&CABLES1,&DLG2,&ANKS1A,&PADI3,&PKN2,&CDK6,&MBNL1,&TIMM23,&CAPN10,&STXBP5,&IGF2R,&TXNRD1,&INPP4B,&SPATS2L,&GALNT9,&JAM3,&WIZ,&EPN1,&BRSK2,&LOC150622,&PRDM16,&CDH5,&CHD7,&AP3M2,&HRH2,&COL27A1,&DCLK2,&NEDD4L,&COL4A1,&ALPK3,&ADARB2,&SNX25,&WDFY4,&HIAT1,&CREB5,&TRANK1,&ANXA2,&C9ORF3,&CADPS,&GDF10,&PDLIM7,&ADORA1,&ZNRF3,&ATP2B2,&ATP2B4,&CD44,&GAB2,&WWP2,&TRAK1,&RAPGEF5,&RAPGEF4,&FAM53B,&FHAD1,&DAB2IP,&RNF220,&EFNB2,&TANC1,&UBR4,&DCTN4,&EEPD1,&LRCH1,&NAV1,&NAV2,&PDGFRL,&PDGFRA,&CAMK1,&EXT1,&FAM172A,&GCNT3,&GCNT2,&DENND2A,&TMCC3,&CAPZB,&EPHB2,&SEMA5B,&EPHB6,&VRK2,&MACF1,&

1.26

UP_TISSUE Epithelium 166 2.13 4.49E>07 PDLIM7,&CTPS,&UTRN,&PKMYT1,&RNF216,&TPD52,&VCL,&KANK2,&SHB,&NUDCD3,&CD44,&WWP2,&SMARCD3,&SND1,&GIT2,&DNAJC5,&STK39,&FNDC3B,&MYST4,&EGFR,&CASKIN2,&DAB2IP,&OPA1,&CA10,&DTL,&STK24,&RREB1,&EFNB2,&UBR4,&CDO1,&CTNNA3,&RPTOR,&TACC2,&TRIM37,&TNS1,&PTGFRN,&AKAP1,&SMARCA2,&MYO18A,&SLC40A1,&TNFAIP1,&HDLBP,&CATSPERB,&SETD1B,&SSH2,&CHCHD3,&MYO9B,&ANLN,&TRRAP,&ACP1,&EPHB2,&SEMA5A,&PTK2,&MACF1,&SCN9A,&AXIN2,&MN1,&ZNF423,&PHACTR2,&RAB8A,&LPP,&TGFBR2,&ACACA,&TEAD1,&ZBTB40,&OXSR1,&SHANK2,&EPS15,&WDR66,&PDZD8,&MYO10,&PLEKHA5,&GPATCH2,&MAP4,&ABL1,&ATG16L1,&CHAF1B,&RERE,&MYH10,&PC,&KIAA0802,&MAD1L1,&ACOX1,&CYB5R2,&FOXK1,&TLN2,&FERMT2,&TTLL5,&CTCF,&ZBTB38,&AKT1,&USP19,&GARNL3,&CTTN,&NDE1,&PARN,&PWWP2A,&PCBP2,&EDC3,&LRRFIP1,&ADCY10,&CABLES1,&PRKCA,&FMNL2,&FILIP1,&TLE3,&PFKP,&PKN2,&ADNP,&TLE4,&SLC9A3R1,&HERC1,&FLNB,&FMN1,&EPB41L2,&CCDC50,&RAB11FIP5,&STXBP5,&CCDC52,&IGF2R,&KHSRP,&C2ORF3,&GRAMD1B,&WIZ,&EPN1,&ABLIM1,&PRKCZ,&SHROOM3,&NUP160,&SPOCK2,&CALD1,&PPFIA1,&MGMT,&C10ORF11,&GNG12,&C2ORF88,&STAU2,&COL17A1,&NUMA1,&PLEKHG1,&CHD7,&COL27A1,&PKD2,&PKD1,&BCL9L,&NEDD4L,&PPAP2B,&AFAP1,&SYNPO,&GEMIN5,&TNXB,&NF2,&SNX25,&MAP1B,&LMNA,&ANXA2,&SLC16A3,&TEX15,&ADCY9,&SVIL,&ABCC4,&ARAP2,&WDR20,&BCAR3,&BMPR1A,&ABCC6

1.45

UP_TISSUE Amygdala 47 0.60 3.07E>04 FRAS1,&CALD1,&SLC37A4,&BRSK2,&PAQR6,&FAM19A2,&LOC150622,&EPB41L4B,&CX3CL1,&RRAGD,&STAU2,&DNAH6,&GARNL3,&TMEM108,&RGS12,&ANK3,&EIF3F,&SPATA2,&DCLK2,&PDE8B,&DNAJC5,&PHYHIPL,&FMNL2,&DFNA5,&ABR,&CA10,&PTPRN2,&MAP1B,&MAML2,&BANP,&FOXJ3,&DOCK5,&DCTN4,&GPR98,&ATXN7L3,&ARHGEF10,&TMEM132D,&CADPS,&EPS15,&TRIM37,&PLEKHA5,&ABCC1,&KIAA1217,&MYO18A,&WDR20,&TNFAIP1,&KIAA0240

1.74

UP_TISSUE Cerebellum 47 0.60 2.30E>03 KIAA0802,&ARSB,&HDLBP,&XRCC3,&GCNT2,&MGMT,&SMTNL2,&ZFYVE21,&STAU2,&ACOT7,&CDH20,&CHD7,&SPEG,&GIT2,&ABHD12,&RAP1GAP2,&DLG2,&GEMIN5,&KCNMA1,&PHYHIPL,&LCMT1,&F10,&ABR,&BEND6,&CA10,&SLC12A4,&EPM2A,&TGFBR2,&HRNBP3,&RAB7L1,&GAS7,&C8ORF31,&SLC16A3,&ATXN1,&CLEC16A,&IFI27,&TRAPPC9,&STXBP5,&PLXDC1,&ARF3,&ARF4,&MAP4,&MTOR,&ADAM22,&SLC46A3,&ARAP2,&BTBD11

1.58

UP_TISSUE Whole&embryo 13 0.17 3.40E>03 SMG6,&AGBL4,&MAN1B1,&MRGPRF,&BANP,&CREB5,&ARID1B,&FOXP1,&HMCN1,&COL27A1,&GALNS,&ATG16L1,&PMP22

2.67

UP_TISSUE Endothelial&cell 9 0.12 4.48E>03 PLXDC1,&LIPG,&ITGA2,&DOCK5,&FLNB,&CDH5,&TNFAIP1,&VCL,&TACC2 3.42UP_TISSUE Hippocampus 34 0.44 4.48E>03 GALNT2,&PRKCZ,&PLXNA4,&NUAK1,&ADORA1,&PDE6B,&PTK2,&ACOT7,&FAM107B,&

PDE4B,&SPATA2,&SLC35F3,&DNAJC5,&RAPGEF4,&FAM53B,&FRS2,&GPT2,&PSMD9,&MLC1,&ABR,&DOCK9,&C3ORF26,&PRKCB,&CTNNA2,&SLC16A3,&CASS4,&SFRP1,&GRM7,&TSSK1B,&TMCO3,&PIP4K2A,&BTBD11,&FAM172A,&SLC9A1

1.67

UP_TISSUE Trachea 29 0.37 5.78E>03 GCNT2,&NUP160,&SLC15A2,&C2ORF88,&CDKAL1,&STAU2,&C1QTNF7,&MACF1,&MYOCD,&WWP2,&MSI2,&FNDC3B,&FHAD1,&UTP23,&LPP,&FAM111B,&CREB5,&RAB7L1,&GAS7,&CTNNA3,&CPT1A,&EPS15,&PLK2,&PDGFRA,&TXNRD1,&ATP6V0A4,&ZNF438,&ANKFY1,&PROS1

1.73

UP_TISSUE Platelet 38 0.49 7.33E>03 ABLIM1,&PDLIM7,&CTPS,&C10ORF11,&IQGAP2,&MYO9B,&CAPZB,&SCARF1,&TPM4,&SRC,&VCL,&CTTN,&TBC1D5,&DNAJC5,&STK39,&RASA3,&PRKCA,&RAB8A,&ANKS1A,&MLC1,&MAP1B,&ITGA2,&SLC9A3R1,&FLNC,&PRKCB,&EPS15,&NCK2,&CASS4,&TNS1,&CD36,&FYN,&CLIC4,&STXBP5,&SVIL,&CAMK1,&MAP4,&MYO18A,&SLC9A1

1.57

UP_TISSUE Aorta&endothelial&cell 10 0.13 9.90E>03 GBE1,&LTBP2,&HSPG2,&TFPI,&TEAD1,&OSBPL10,&POLQ,&CDH5,&COL5A1,&LGR4 2.76UP_TISSUE Heart 37 0.47 1.87E>02 APOBEC2,&CAMTA1,&PDLIM7,&TNFRSF25,&LGMN,&PPP1R12B,&ADORA1,&SMOC2,&

ATP2B4,&MYOCD,&GATA6,&PPP2CB,&SH3BGR,&LRRFIP1,&KCNMA1,&ALPK2,&SNX25,&ATP6V1H,&CYYR1,&BANP,&FLNC,&PXDNL,&EPB41L2,&AFP,&PITPNM2,&TNS1,&ADCY9,&SFRP1,&APCDD1L,&CD59,&NOTCH4,&MAP4,&MAT2B,&PTGFRN,&IKBKB,&ZNF438,&SLC9A1

1.48

UP_TISSUE PCR&rescued&clones 42 0.54 2.71E>02 FRAS1,&HDLBP,&NDST4,&GRIP1,&C10ORF118,&PKMYT1,&GGT1,&C20ORF194,&LY9,&RORA,&CDH5,&STAU2,&ARHGAP12,&RGS12,&GLP2R,&NRG2,&RUNX2,&EGFR,&DFNA5,&PKN2,&HSPG2,&TEAD1,&ZBTB40,&GALNTL1,&GAS7,&SHANK2,&HPR,&DOCK4,&RASSF3,&P2RX6,&TNS1,&PARP6,&FBXO32,&GRK5,&ADAM22,&ANAPC7,&PTGFRN,&ABL1,&ATP6V0A4,&C6ORF174,&ABCC6,&MYH10

1.40

UP_TISSUE Fetal&kidney 15 0.19 3.10E>02 FRAS1,&HDLBP,&CNOT1,&DNAH7,&SUFU,&PLAGL1,&WISP1,&FREM2,&ANK3,&CCDC52,&AAGAB,&PBX1,&POLQ,&ANKFY1,&ODZ4

1.87

UP_TISSUE Mammary&gland 27 0.35 3.13E>02 FLJ14107,&PDLIM7,&PRKAG2,&PLAGL1,&CTTN,&DYSF,&PKD2,&EPSTI1,&SFRS12,&DFNA5,&PIK3C2B,&SGOL1,&UBR4,&ACACA,&LMCD1,&PTPRU,&HPR,&EEPD1,&CD36,&APCDD1L,&THSD4,&ARL8A,&TXNRD1,&KIAA1217,&ATG16L1,&EPN1,&IL22RA2

1.53

UP_TISSUE Colon&tumor 4 0.05 3.21E>02 CLCN3,&FERMT2,&ATP8B1,&PDGFRA 5.60

UP_TISSUE Retina 24 0.31 3.26E>02 ABLIM1,&PHYHIPL,&CLCN3,&OLFML2B,&POU6F2,&NPR1,&FAM19A2,&RORA,&DACH1,&CAPZB,&STAU2,&NETO1,&VCL,&EPB41L2,&FMN1,&RGMA,&PDE6B,&SORBS1,&PDE4B,&TEF,&ANO2,&KCTD16,&SV2A,&DLG2

1.58

UP_TISSUE Foreskin 7 0.09 3.51E>02 AKT1,&ACOX1,&COL17A1,&CD44,&PDGFRA,&NFIX,&SCEL 2.85UP_TISSUE Skeletal&muscle 34 0.44 6.60E>02 TLN2,&ACP1,&ATP2B2,&DYSF,&SORBS1,&SH3GLB2,&FMO2,&CCDC101,&SYNPO,&ALPK2,&

FILIP1,&MYO1B,&TPD52L1,&PARK2,&OXSR1,&PTPRU,&FBP2,&DOCK5,&FLNC,&FLNB,&TACC2,&AMPD1,&MAP4K3,&ATXN1,&EPB41L2,&MYO10,&P2RX6,&CD36,&PDE7A,&KHSRP,&SLC41A1,&FBXO32,&KIAA1217,&UGP2

1.35

UP_TISSUE Fetal&lung 7 0.09 6.93E>02 PLAT,&CLCN3,&TNFRSF25,&CDON,&PDGFRL,&DEFB106B,&SUFU 2.41UP_TISSUE Placenta 163 2.09 7.43E>02 XRCC3,&LTBP2,&LGMN,&ASCC1,&NT5DC3,&GGT1,&RNF216,&RBM9,&KANK2,&ST3GAL1,&

SHB,&ST3GAL3,&NUDCD3,&FLI1,&DYSF,&ANK3,&WWP2,&ATG7,&NT5C2,&FRS2,&FNDC3B,&SPON1,&EGFR,&CASKIN2,&BAIAP2,&CRTAP,&MRGPRF,&METTL7A,&GRHL2,&C14ORF179,&RPTOR,&TACC2,&LAT2,&CD36,&NAV2,&PDGFRA,&VGLL4,&EXT1,&SLC40A1,&FAM172A,&FRAS1,&CLCN3,&HDLBP,&CATSPERB,&GCNT2,&ENPP1,&MAPKAPK5,&NEDD9,&MYO9B,&DAAM1,&ACP1,&EPHB2,&PLAGL1,&PTK2,&GALNS,&KIAA0247,&PLAT,&LCMT1,&PHACTR2,&NOMO3,&CCDC80,&RAB7L1,&C8ORF31,&HOXB3,&SEMA6A,&PLEKHA5,&CASS4,&ITGA5,&SLC7A1,&THSD4,&ARF4,&NOTCH4,&TGFBR3,&RAD54B,&ANTXR2,&PIP4K2A,&ATG16L1,&APOL5,&SLC9A1,&IL22RA2,&ARSB,&CYB5R2,&FOXK1,&ZNFX1,&FERMT2,&MRVI1,&PRKAG2,&MAN1B1,&ACOT2,&TTLL5,&CTCF,&ARHGAP12,&AKT1,&CTTN,&NDE1,&DIP2C,&DNAJC11,&EDC3,&SLC35D2,&PDE8B,&TRPV6,&LOXL2,&BHLHE41,&FGF2,&LOXL1,&ANO6,&DPP4,&CTBP1,&CTBP2,&RXFP1,&PFKP,&ADNP,&PRKCH,&SLC9A3R1,&FLNB,&NCK2,&CLIC4,&VCAN,&TXNRD1,&SPATS2L,&ADAM12,&NKD2,&MGMT,&GLIS1,&PART1,&C2ORF88,&CDKAL1,&GPRC5B,&CDH5,&STAU2,&TPM4,&C3ORF62,&GALK2,&GALNT10,&CHD7,&PEX19,&SORBS1,&DISP1,&MSI2,&FBN2,&PPAP2B,&HSD17B7,&TES,&FAM26D,&SOAT1,&COL4A1,&PTPRE,&HIAT1,&C1ORF21,&NPR1,&CREB5,&ZNF358,&COL5A1,&ANXA2,&CSGALNACT1,&FYN,&CDON,&SLC6A6,&LIPG,&MAT2B,&LRP2,&ARAP2,&BMPR1A

1.11

UP_TISSUE Lung 127 1.63 9.83E>02 FGF18,&GGT1,&KANK2,&CD44,&PELI2,&GLP2R,&FAM53B,&GPT2,&MYST4,&FNDC3B,&C12ORF65,&CARS,&SLC12A8,&SPARCL1,&CA12,&SGOL1,&CRTAP,&EFNB2,&UBR4,&SCEL,&TRAPPC9,&LRCH1,&PDGFRA,&VGLL4,&EXT1,&ZNF438,&EMP2,&TNFAIP1,&GCNT2,&SSH2,&NEDD9,&ESM1,&RRAGD,&CHCHD6,&SRC,&LEAP2,&LLGL2,&PLAGL1,&ALCAM,&MACF1,&EIF3F,&SFRS12,&MRPS27,&LCMT1,&A2LD1,&NOMO3,&CCDC24,&C3ORF26,&TPD52L1,&FOXP1,&ITGA9,&PLEKHA5,&NXN,&APCDD1L,&PTCD3,&ETS1,&ARF3,&GPATCH2,&CCDC33,&SLC25A19,&PIP4K2A,&ABL1,&IKBKB,&PC,&MYH10,&PNLIP,&FOXK1,&ARSG,&FERMT2,&ACOT2,&MAN1B1,&CBFA2T3,&TTLL11,&CCRL2,&WISP1,&DNAJC11,&PCBP2,&SLC35D2,&CHST11,&TICAM1,&BHLHE41,&LOXL1,&NRG2,&CABLES1,&PARVG,&PRKCA,&ANKS1A,&CTBP1,&MRPL4,&FILIP1,&PRKCH,&FOXJ3,&NCK2,&BLMH,&SLC41A1,&TXNRD1,&LEPREL1,&CALD1,&GLIS1,&SLC37A4,&SEC14L1,&DNAH6,&NUMA1,&NPAS2,&RGS12,&CHD7,&PEX19,&AP3M2,&FMO2,&NEDD4L,&AFAP1,&DPT,&C11ORF2,&TNXB,&PLA2G10,&NF2,&MAP1B,&LMNA,&HPR,&C9ORF3,&AFP,&C5ORF36,&GSPT1,&FYN,&MGST2,&BCAR3,&GOLGB1

1.12

UP_TISSUE Aortic&endothelium 4 0.05 9.84E>02 CLCN3,&ANTXR2,&FBN2,&FLNB 3.58

Supplementary Table 7. Atherosclerosis-specific dm-CpGs mapping within 100kb from known atherosclerosis-related human SNPs _______________________________________________________________ CpG ID SNP/mapping Distance Gene* (kb) _______________________________________________________________ cg26248114 rs17114036/1p32.2 58.3 cg16738453 rs17114036/1p32.2 69.0 PPAP2B cg08655800 rs599839/1p13.3 85.0 KIAA1324 cg03880611 rs2706399/5q31.1 19.4 PDZD2 cg18410110 rs2706399/5q31.1 93.5 PDZD2 cg15542608 rs12526453/6p24.1 100.0 PHACTR1 cg14601709 rs17609940/6p21.31 3.8 ANKS1A cg22946615 rs2505083/10p11.23 82.4 cg04829143 rs2505083/10p11.23 49.3 cg23125970 rs4773144/13q34 41.6 COL4A1 cg02558625 rs4773144/13q34 8.6 COL4A1 cg04887675 rs4773144/13q34 3.2 COL4A1 cg22155786 rs4773144/13q34 33.1 COL4A1 cg06217769 rs216172/17p13.3 3.7 SMG6 cg26927232 rs216172/17p13.3 5.6 SMG6 _______________________________________________________________ *Gene mapping within 100 kbp from SNP and containing a dm-CpG

dna methylation map of human atherosclerosis

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