Single-vaccine solution protects against BRD-causing viruses & bacteria

at every stage of production*

YOU NEED CHOICES. Elanco now brings you a comprehensive line of cattle vaccine

health management solutions for your operation.

*Approved for cattle 60 days of age or older

The first BVD type 2 MLV vaccine, Titanium® has become well-known for helping protect stocker and feeder cattle against respiratory disease.

Research cited below shows Titanium brand vaccines:

• Did not affect feed intake2

• Did not cause post-vaccinal stress as measured by body temperature, feed intake, injection-site reaction and white blood cell counts2,3,4,6

• Are safe to use in nursing calves and during pregnancy7*

• Did not affect milk production1

In fact, studies document that the portfolio of Titanium vaccines protects against BVD, types 1a and 2 (Figure 1), IBR, PI3, BRSV and five strains of Leptospira, including L. hardjo-bovis — common pathogens that cause costly respiratory and reproductive disease.3,5,8,9,10*

Titanium’s MLV combination vaccines provide this protection quickly by stimulating cell-mediated immunity (Figure 2).

Now, the convenience of whole-herd protection

With USDA’s approval of four combination vaccines for nursing calves and pregnant cows, Titanium brand vaccines now can protect your whole herd against costly disease pathogens. Be sure to follow label and use directions.

Proven and trusted

Four Titanium combinations are now USDA-approved for use in pregnant cows and nursing calves:

• Titanium 5 + PH-M• Titanium 5 L5 HB• Titanium 5• Titanium 4 L5

5

4

3

2

1

0

1 2 3 4 5 6 7 8 9 10 11 12 13 14

Figure 1. BVD type II challenge study — clinical signs8

Days post-challenge

Clin

ical

sig

ns*

mea

n sc

ore

Titanium 5 L5 (intramuscular)

Titanium 5 L5 (subcutaneous)

Unvaccinated controls

*Clinical signs monitored included depression, respiratory distress, nasal discharge, diarrhea, oral lesions, ocular discharge, appetite and coughing.

20

15

10

5

00 3 5 7 21 35 60 90

Figure 2. IBR study — post-vaccinal cell-mediated immunity9

T-h

elp

er ly

mp

hocy

te

inte

rleu

kin-

2 re

cep

tor-

leve

l ex

pre

ssio

n in

dex

(EI)

Days post-vaccination

Titanium 5 L5Unvaccinated controls

The portfolio of nine Titanium MLV vaccines provides proven protection against respiratory and reproductive viruses. Several combinations are now approved for use in pregnant cows and nursing calves (see product names below).

*See reference guide on back cover

Figure 3. M. Haemolytica challenge study survival rate11

100%

80%

60%

40%

20%

0%Day 1 Day 2 Day 3 Day 4

Sur

viva

l Rat

e

Group 1: PH-MGroup 2: Titanium 5 + PH-MControl

Protects against the two bacteria most associated with BRD:11,15 • Mannheimia haemolytica — the bacterium most

frequently isolated from lungs of cattle with BRD• Pasteurella multocida — an important cause of

bacterial pneumonia

And five economically important virus strains:12,13

• BVD, types 1 and 2 • PI3

• IBR • BRSV

Contains a research-proven M. haemolytica leukotoxoid and other antigens to stimulate an immune response to BRD- causing viruses and bacteria.

Includes a low-reactive14, water-soluble adjuvant, and is proven safe for cattle as young as 2 months of age.

Proven effective and safe at every stage of production*

Evaluated under USDA requirements, Titanium 5 + PH-M was proven safe and effective for cattle at all stages of production, with no interference between the viral and bacterial components of the vaccine. Research comparing vaccinated calves to controls after infection with M. haemolytica showed Titanium 5 + PH-M:11

• Reduced lung lesions† by 82% (P < 0.01)• Reduced clinical signs of infection significantly (P < 0.01)

Studies also showed Titanium 5 + PH-M:• Provided the same viral protection (BVD, types 1 and 2,

IBR, PI3, BRSV) as Titanium 512,13

• Protected against severe clinical signs of BRD11,12,13

• Resulted in no adverse events beyond minimal injection-site swelling14

*Approved for cattle 60 days of age or older†Mitigated fraction: the effect of a vaccine in reducing severity of disease

Single vaccine with virus and bacteria protection

Helping your cattle overcome the one-two punch of viruses and bacteria requires a vaccine solution that provides a broad immune response against the bacteria and viruses most associated with BRD.

Titanium 5 + PH-M delivers a broad immune response against the bacteria and viruses most associated with bovine respiratory disease (BRD) in a single vaccine for cattle as young as 2 months of age.11,12,13,14

Figure 4. Titanium 5 + PH-M safety study injection-site evaluation14

Calves vaccinated on Day 1 and revaccinated on Day 21.

Per

cent

of

anim

als

Day 4-6 Day 21 Day 25-27 Day 42

100%

80%

60%

40%

20%

0%

Injection-site swelling measurements

0 <1.5 cm >5 cm1.5 - 5 cm

Cow-calf and dairy producers alike depend on Master Guard® brand vaccines to protect against common reproductive and respiratory pathogens in pregnant and open cattle.*

To deliver effectiveness and reproductive safety, Master Guard features killed antigens for BVD, types 1a and 2, and IBR (see Figure 5 for duration-of-immunity research). The two MLV components — the same as found in Titanium — enhance cattle’s cell-mediated immune response for BRSV (Figure 6) and PI3.

Lepto antigens add even more reproductive protection

Master Guard 10 HB also provides protection against five species of Leptospira spirochetes, including L. hardjo-bovis, the most common species of Leptospira found in the United States.

Master Guard vaccines:*• Do not affect milk production‡16

• Can be given to cows and heifers at any stage of gestation

• Allow the convenience of whole-herd vaccination in cattle 5 months of age and older

Trust Master Guard brand vaccines to provide the reproductive safety you want, and the protection you need against key reproductive and respiratory pathogens.*

‡No statistical difference during nine-day duration of study*See reference guide on back cover

Single vaccine with virus and bacteria protection

Two combinations — effective 5-way or 5-way plus Lepto protection

20

15

10

5

0

Figure 6. BRSV study — post-vaccinal cell-mediated immunity5

Gam

ma

del

ta T

-lym

pho

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in

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n-2

rece

pto

r-le

vel (

EI)

Days post-vaccination

BRSV component in Master Guard & TitaniumUnvaccinated controls

0 3 5 7 21 35 60 90

0196† 198 200 202 204 206 208 210

5

10

15

20

Figure 5. IBR challenge study — clinical signs17

Clin

ical

sig

ns††

mea

n sc

ore

Days post-vaccination†Day of IBR challenge.††Clinical signs monitored included respiratory distress and rectal temperatures.

IBR/BVD components in Master GuardUnvaccinated controls

Master Guard vaccines contain a unique combination of killed and MLV components to provide disease protection that’s proven safe and effective in cattle10 — including pregnant cows and nursing calves.

Master Guard offers the safety of a killed vaccine (BVD types 1 and 2, IBR) with the performance of a modified-live vaccine (PI3, BRSV).

When to use — vaccines from Elanco are designed to offer the protection you need, when and where you need it.

STOCKER

ArrivalRevaccinate(two to four weeks)

Titanium 5 + PH-M

Titanium 5

Master Guard 5

Previously vaccinated Unknown history

FEEDYARD

Arrival ReimplantingRevaccinate in

two to four weeks

Titanium 5 + PH-M

Titanium 5

Titanium 4 L5

Titanium 3 LP

Titanium 3

Titanium IBR

Lightweight, high-risk cattle Heavyweight, low-risk cattle

STOCKER

ArrivalRevaccinate(two to four weeks)

Titanium 5 + PH-M

Titanium 5

Master Guard 5

Previously vaccinated Unknown history

FEEDYARD

Arrival ReimplantingRevaccinate in

two to four weeks

Titanium 5 + PH-M

Titanium 5

Titanium 4 L5

Titanium 3 LP

Titanium 3

Titanium IBR

Lightweight, high-risk cattle Heavyweight, low-risk cattle

While following label directions, work with your veterinarian to determine the best way to incorporate these trusted vaccines into your herd-health protocols.

General use guidelines

The full value of a true partnership

Equipped with a full line of disease treatment, prevention and control solutions, you can count on your Full Value Beef™ experts at Elanco to help you make informed health

management decisions. By establishing a strong foundation in data analytics and helping you identify the economic factors that have the biggest impact on your bottom line,

you and your Elanco representative can work together to discover meaningful profit opportunities.

YOU NEED CHOICESELANCO VACCINE REFERENCE GUIDE

When bringing cows and replacement heifers with an unknown health history into your herd:1. Vaccinate upon arrival2. Revaccinate in two to four weeks

Annual revaccination of cows is recommended

COW-CALF

Calves

Birth Branding/Preweaning

Weaning/Preconditioning

Titanium 5 + PH-M

Titanium 5 L5 HB

Titanium 5

Master Guard 10 HB

Master Guard 5

Breeding Pregnancy CalvingPrebreeding(30 to 60 days before)

Heifers and cows

*

*

*May be used in calves at least 5 months of age

*

For all products: The label contains complete use information, including cautions and warnings. Always read, understand and follow the label and use directions. Do not vaccinate within 21 days of slaughter.

Precautions: Do not use Titanium BRSV 3, Titanium 3 LP, Titanium 3, Titanium IBR LP and Titanium IBR in pregnant cows or in calves nursing pregnant cows. Abortions may result.

1Terhaar, B. 2000. Effect of vaccination with Titanium 5 on milk production in dairy cattle. Study No. TR-09. Published by Agri Laboratories Ltd.2Terhaar, B. 2001. Evaluating the effects of vaccine-induced stress on productivity. Study No. TR-13. Published by Agri Laboratories Ltd.3Terhaar, B. 1999. A comparison of Titanium 5 L5 and Bovishield 4 L5 following virulent infectious bovine rhinotracheitis virus challenge. Study No. TR-04. Published by Agri Laboratories Ltd.4Terhaar, B. 1998. Final report on field safety evaluation of Titanium 5 L5. Study No. TR-03. Published by Agri Laboratories Ltd.5Data available upon request.6Terhaar, B. Effect of vaccination with Titanium 5. Study No. TR-11. Published by Agri Laboratories Ltd.7Field safety evaluation in pregnant cows. Study No. 02-11 Rev. No. 1. Published by Agri Laboratories Ltd. 8Ohnesorge, W. C. 1998. Immunogenicity of a modified live bovine viral diarrhea virus, type 1 and type 2, vaccine following BVDV 890 (type 2) challenge. Study No. 97-24.9Endsley, J. J., M. J. Quade, B. Terhaar, and J. A. Roth. 2002. Bovine viral diarrhea virus type 1- and type 2-specific bovine T lymphocyte-subset responses following modified-live virus vaccination. Vet. Ther. 3(4):364-372.

10Immune response of calves to MLV and killed vaccines at branding and weaning -- in the face of maternal antibodies. Study No. TR-20. Published by Agri Laboratories Ltd.11Milliken, G. A. 2013. Mannheimia haemolytica efficacy studies demonstrating the absence of excessive interference of Titanium products with the Mannheimia haemolytica-Pasteurella multocida bacterin-toxoid.

12Demonstration of the compatibility of components between APHIS product codes 1181.20 (Establishment 213) and G935.04 (Establishment 315) APHIS product code 45B9.20. Study No. 2010-01 Rev. 1.

13Efficacy study for BRSV fraction to demonstrate compatibility of the BRSV component in APHIS product code: 45B9.20 (unlicensed). Study No. 2011-05 Rev. 1.14Porter, M. 2011. Field safety evaluation of bovine rhinotracheitis-virus diarrhea-parainfluenza3-respiratory syncytial virus vaccine, modified live virus, APHIS product code 1181.20 (establishment 213) in combination with Mannheimia haemolytica-Pasteurella multocida bacterin-toxoid, APHIS product code: G935.04 (establishment 315). Protocol No. 2011-01, Rev. 02

152010. The Merck Veterinary Manual. 10th ed. Respiratory diseases of cattle. p. 1323. C. Kahn, ed. Merck & Co. Inc., Whitehouse Station, NJ.16Terhaar, B. 2000. Master Guard Preg 5: Effect of vaccination on milk production in dairy cattle. Study No. TR-10. Published by Agri Laboratories Ltd.17Sibbel, R. L., E. P. Bass, and P. C. Thomas. 1988. How long will a killed IBR vaccine protect against challenge? Vet Medicine. 90-94.

Elanco, Full Value Beef, Master Guard®, Titanium® and the diagonal bar are trademarks owned or licensed by Eli Lilly and Company, its subsidiaries or affiliates.© 2014 Elanco Animal Health.VAC 31354-2

USBBUMUL00892

YOU NEED CHOICESELANCO VACCINE REFERENCE GUIDE

Titanium 5 + PH-M 10 dose / 50 dose 3 3 3 3 3 3 3 *

Titanium 5 L5 HB 5 dose / 10 dose / 50 dose 3 3 3 3 3 3 3 3 3 3 3

Titanium 5 10 dose / 50 dose 3 3 3 3 3

Titanium 4 L5 50 dose 3 3 3 3 3 3 3 3 3

Titanium BRSV 3 50 dose 3 3 3

Titanium 3 LP 50 dose 3 3 3 3

Titanium 3 10 dose / 50 dose 3 3 3

Titanium IBR LP 50 dose 3 3

Titanium IBR 10 dose / 50 dose 3

Master Guard 5 25 dose 3 3 3 3 3 **

Master Guard 10 HB 10 dose / 25 dose 3 3 3 3 3 3 3 3 3 3 3 **

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MLV Killed* Approved for cattle 60 days of age or older**May be used in calves at least 5 months of age