telencephalon
DESCRIPTION
Telencephalon. White matter . Basal ganglia. Telencephalic white matter. Projection fibers Corona radiata Commissural fibers Corpus callosum rostrum, genu, trunkus, splenium Commissura anterior Commissura fornicis Association fibers Fibrae arcuatae breves Fibrae arcuatae longi. - PowerPoint PPT PresentationTRANSCRIPT
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TelencephalonTelencephalon
White matterWhite matter. . Basal gangliaBasal ganglia
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Telencephalic white matter
Projection fibersCorona radiata
Commissural fibers
Corpus callosumrostrum, genu, trunkus, splenium
Commissura anteriorCommissura fornicis
Association fibers
Fibrae arcuatae breves
Fibrae arcuatae longi
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Association fibersAssociation fibers
1. F1. Fasciculus longitudinalis superiorasciculus longitudinalis superior
2. 2. Fasciculus longitudinalis inferiorFasciculus longitudinalis inferior
33. . CCingulumingulum
4. Fasciculus uncinatus4. Fasciculus uncinatus
5. Fibrae arcuatae brevae5. Fibrae arcuatae brevae
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1. Fasciculus longitudinalis superior 3. Fasciculus uncinatus 2. Fasciculus occipitofrontalis 4. Fasciculus perpendicularis
inferior occipitalis
Association fibersAssociation fibers ((lateral aspectlateral aspect))
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1. Cingulum 4. Fasciculus occipitofrontalis superior2. Fasciculus uncinatus 5. Fasciculus perpendicularis occipitalis3. Fasciculus longitudinalis inferior
Asociation fibersAsociation fibers ((medial aspectmedial aspect))
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Speech areasSpeech areas
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Commissural fibersCommissural fibersCCorpus callosumorpus callosum symmetrical areas of the hemispheressymmetrical areas of the hemispheres
splenium, corpus, genu, rostrumsplenium, corpus, genu, rostrum
CCommissura anteriorommissura anterior
temporal lobestemporal lobes
olfatory bulbsolfatory bulbs
CCommisssura posteriorommisssura posterior leftleft and right parts ofand right parts of tectumtectum & &
tegmentum of midbraintegmentum of midbrain
Commissura fornicisCommissura fornicis
between both crura of fornixbetween both crura of fornix
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CCorpus callosumorpus callosum - - forceps minorforceps minor
- forceps major- forceps major
- tapetum- tapetum
Commissura anteriorCommissura anterior
- pars anterior- pars anterior
-- pars posteriorpars posterior Commissura anteriorCommissura anterior((frontal sectionfrontal section))
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Commissural fibers
1. Corpus callosum 3. Forceps minor2. Commissura anterior 4. Forceps major
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Lateralisation of functionsLateralisation of functions
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А. А. Dominant hemisphreDominant hemisphre - - mention mention
the stimulusthe stimulus
BB. . Nondominant hemisphereNondominant hemisphere --
points the stimuluspoints the stimulus
CC. . AnomiaAnomia – – can not name stimuli on can not name stimuli on
the left handthe left hand
DD.. AlexiaAlexia in the left visual fieldsin the left visual fields
EE.. TestTest – – hybrid facehybrid face - -
the patient answers manthe patient answers man, , but but
point the womanpoint the woman
SSplit brain syndromeplit brain syndrome
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Projection fibersProjection fibers
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11. . Crus anteriorCrus anterior
betweenbetween nucl. caudatus и nucl. lentiformis nucl. caudatus и nucl. lentiformis
-- stripes of grey matterstripes of grey matter
22. . GenuGenu
33. . Crus posteriorCrus posterior
Pars thalamolentiformisPars thalamolentiformis- betweenbetween thalamus thalamus && nucl. lentiformis nucl. lentiformis
Pars retrolentiformisPars retrolentiformis
Pars sublentiformisPars sublentiformis
Capsula internaCapsula interna
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Capsula interna
1. Tractus corticonuclearis
2. Tractus corticospinalis
3. Fibrae corticothalamicae
4. Fibrae thalamocorticales
5. Radiatio acustica
6. Radiatio optica
14. Fibrae corticorubrales
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White matter (frontal section)
1. Corpus callosum
2. Capsula interna
3. Fasciculus occipitofrontalis
superior
4. Fasciculus longitudinalis
superior
5. Fasciculus occipitofrontalis
inferior
6. Cingulum
7. Fasciculus uncinatus
8. Fasciculus longitudinalis
inferior
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Basal gangliaBasal ganglia
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LocationLocation
Section through the base of hemisphere exposesSection through the base of hemisphere exposes
aa. . Paired nuclear massesPaired nuclear masses within the hemisphereswithin the hemispheres..
b. Surounded by white matter b. Surounded by white matter (capsula interna, (capsula interna,
capsula externa, capsula extrema)capsula externa, capsula extrema)
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Components of theComponents of the Basal gangliaBasal ganglia
Corpus StriatumCorpus Striatum
Striatum ----- Caudate Nucleus & PutamenStriatum ----- Caudate Nucleus & Putamen
Pallidum ----- Globus Pallidus (GP)Pallidum ----- Globus Pallidus (GP)
Substantia NigraSubstantia Nigra
Pars Compacta (SNc)Pars Compacta (SNc)
Pars Reticulata (SNr)Pars Reticulata (SNr)
Subthalamic Nucleus (STN)Subthalamic Nucleus (STN)
Ventral Striatum Ventral Striatum ии Ventral Pallidum Ventral Pallidum
Nucleus Accumbens SeptiNucleus Accumbens Septi
Noncholiergic part ofNoncholiergic part of Substantia Innominata Substantia Innominata
Basal gangliaBasal ganglia ComponentsComponents Basal gangliaBasal ganglia ComponentsComponents
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STRIATUMSTRIATUM
Nucleus CaudatusNucleus Caudatus Caput, (Corpus), CaudaCaput, (Corpus), Cauda
Caudolenticular bridges of grey matterCaudolenticular bridges of grey matter
PutamenPutamen
Striatum VentralisStriatum Ventralis: : Nucleus Accumbens (Septi)Nucleus Accumbens (Septi)
Basal ganglia ComponentsBasal ganglia Components Basal ganglia ComponentsBasal ganglia Components
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Striatal CompartmentsStriatal Compartments (Mosaic or Modular Organization)(Mosaic or Modular Organization)
1. 1. Striosome (Patches)Striosome (Patches)
- 10-20% of total striatal mass- 10-20% of total striatal mass
- low acetylcholinesterase (AchE) activity- low acetylcholinesterase (AchE) activity
- high substance P (SP), neurotensin (NT), tyrosine hydroxylase- high substance P (SP), neurotensin (NT), tyrosine hydroxylase
- high expression of D- high expression of D11 dopamine receptor dopamine receptor
- high opiate receptor- high opiate receptor
2. 2. MatrixMatrix
- high acetylcholinesterase (AchE) activity- high acetylcholinesterase (AchE) activity
- high somatostatin (SRIF) activity- high somatostatin (SRIF) activity
- high D- high D22 dopamine receptor dopamine receptor
Basal Ganglia Components Basal Ganglia Components Basal Ganglia Components Basal Ganglia Components
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Traditional Concepts of Traditional Concepts of Basal GangliaBasal Ganglia
Corpus StriatumCorpus Striatum
Caudate NucleusCaudate Nucleus
Lenticular Nucleus PutamenLenticular Nucleus Putamen
Globus Pallidus Globus Pallidus PaleostriatumPaleostriatum Pallidum Pallidum
Corpus Amygdaloideum Corpus Amygdaloideum ArchistriatumArchistriatum
NeostriatumNeostriatum Striatum Striatum
Basal Ganglia Introduction Basal Ganglia Introduction Basal Ganglia Introduction Basal Ganglia Introduction
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1. Putamen1. Putamen2. Tail of caudate 2. Tail of caudate
nucleusnucleus3. Caudatolenticular 3. Caudatolenticular
gray bridgegray bridge4. Amygdaloid body4. Amygdaloid body5. thalamus5. thalamus
Lateral surface Lateral surface of basal gangliaof basal ganglia
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1. head of 1. head of caudate nuceluscaudate nucelus
2. body of 2. body of caudate nuceluscaudate nucelus
3. caudatolenticular 3. caudatolenticular gray bridgegray bridge
4. putamen4. putamen
5. tail of 5. tail of caudate nucleus caudate nucleus
6. external segment of 6. external segment of globus pallidus globus pallidus
7. internal segment of 7. internal segment of globus pallidusglobus pallidus
8. amygdaloid body8. amygdaloid body
9. nucleus accumbens 9. nucleus accumbens septisepti
Medial surface of basal gangliaMedial surface of basal ganglia
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PutamenPutamenGlobus pallidusGlobus pallidus external segmentexternal segment internal segmentinternal segmentSubthalamic NucleusSubthalamic NucleusSubstantia nigraSubstantia nigra
Internal capsuleInternal capsule
Components ofComponents ofBasal GangliaBasal Ganglia
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Input Portion Input Portion
STRIATUM STRIATUM
(Caudate Nucleus and Putamen)(Caudate Nucleus and Putamen)
Output PortionOutput Portion
1. 1. PALLIDUM PALLIDUM (Globus Pallidus)(Globus Pallidus)
2. 2. SNr SNr (Substantia Nigra, Pars Reticulata)(Substantia Nigra, Pars Reticulata)
Basal Ganglia ConnectionsBasal Ganglia Connections
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Basal ganglia ConnectionsBasal ganglia Connections
А. Striatum (nucl. caudatus + putamen)
1. Afferent fibersа. Cortex (sensimotor – gyrus paracentralis)b. Thalamus – nucl. centromedianum, NVL, NVAc. Substantia nigrad. Nuclei raphe
2. Efferent fibersa. Pallidum [ [striopallidal]b. SN SN [strionigral]
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B. Globus pallidus (pallidum)
1. Afferent fibers
а. Striatum (striopallidal fibers)
b. Nucleus subthalamicus (fasciculus subthalamicus)
c. Cerebral cortex
d. Substantia nigra
e. Nuclei raphe
2. Efferents fibersa. Common final pathway to thalamus
b. Ansa lenticularis, fasciculus lenticularis, fasciculus subthalamicus
Basal ganglia ConnectionsBasal ganglia Connections
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Basal ganglia ConnectionsBasal ganglia Connections
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Basal Ganglia (Main Motor Circuit) ConnectionsBasal Ganglia (Main Motor Circuit) ConnectionsBasal Ganglia (Main Motor Circuit) ConnectionsBasal Ganglia (Main Motor Circuit) Connections
SupplementarySupplementaryMotor AreaMotor Area
(SMA)(SMA)
PrimaryPrimaryMotor AreaMotor Area
(M I)(M I)
THALAMUSTHALAMUS(VLo, VApc, CM)(VLo, VApc, CM)
STRIATUMSTRIATUM(Putamen)(Putamen)
PALLIDUMPALLIDUM(GPi)(GPi)
pyramidalpyramidal tracttract
LMNLMN
ansaansalenticularislenticularis
lenticularlenticularfasciculusfasciculus
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SMASMA (supplementary motor area)(supplementary motor area)
SMASMA (supplementary motor area)(supplementary motor area)
Basal Ganglia and Pyramidal TractBasal Ganglia and Pyramidal TractBasal Ganglia and Pyramidal TractBasal Ganglia and Pyramidal Tract
upper motor neuronupper motor neuron
UMNUMN
lower motor neuronlower motor neuron
LMNLMN
pyramidalpyramidal tracttract
BASALBASALGANGLIAGANGLIA CIRCUITCIRCUIT
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Functional roleFunctional role
Regulate the motor activityRegulate the motor activity byby intrinsic and extrisic feed-back circuitsintrinsic and extrisic feed-back circuits
Role in the control of movementsRole in the control of movements
Suppress the motor toneSuppress the motor tone
Suppress the excesive and unnecessary movementsSuppress the excesive and unnecessary movements
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Signs in lesion of basal gangliaSigns in lesion of basal ganglia
1. 1. Akinesia & bradykinesiaAkinesia & bradykinesia - - difficulty in initiation and difficulty in initiation and cessation of movementcessation of movement
2. 2. RigidityRigidity of musclesof muscles
3. 3. Involutary movementsInvolutary movements ( (hyperkinesiahyperkinesia) – ) – tremortremor, , ticstics, ,
balismbalism, , choreachorea, , atetosisatetosis, , distoniadistonia
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Basal Ganglia Basal Ganglia Functional Consideration Functional Consideration
Basal Ganglia Basal Ganglia Functional Consideration Functional Consideration
Functional ConsiderationFunctional Consideration
1. 1. Selection Selection of “Preprogramed (learned) motor plans”of “Preprogramed (learned) motor plans”
Basal Gangla Circuit ---- Basal Gangla Circuit ---- Selection MechanismSelection Mechanism
Selection Inability -------- Selection Inability -------- Akinesia and HypokinesiaAkinesia and Hypokinesia
Faulty Selection ----------- Faulty Selection ----------- HyperkinesiaHyperkinesia
2. 2. Generation (learning) Generation (learning) of motor programsof motor programs
Programming of several Programming of several motor fragments motor fragments intointo
complex motor routinescomplex motor routines
Cerebral Palsy Cerebral Palsy ------------- Disordered motor program ------------- Disordered motor program
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SYDENHAM’S CHOREASYDENHAM’S CHOREASYDENHAM’S CHOREASYDENHAM’S CHOREA
- Complication of- Complication of Rheumatic FeverRheumatic Fever- Fine, disorganized , and - Fine, disorganized , and random movements ofrandom movements of extremities, face andextremities, face and tonguetongue- Accompanied by - Accompanied by Muscular HypotoniaMuscular Hypotonia- Typical exaggeration of- Typical exaggeration of associated movements associated movements during voluntary activityduring voluntary activity- Usually recovers- Usually recovers spontaneously spontaneously in 1 to 4 monthsin 1 to 4 months
Clinical FeatureClinical Feature
Principal Pathologic Lesion: Principal Pathologic Lesion: Corpus StriatumCorpus Striatum
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Clinical FeatureClinical Feature
Principal Pathologic Lesion:Principal Pathologic Lesion:
Corpus Striatum (esp. caudate nucleus)Corpus Striatum (esp. caudate nucleus) and Cerebral Cortexand Cerebral Cortex
- Predominantly - Predominantly autosomal dominantlyautosomal dominantly inherited chronic fatal diseaseinherited chronic fatal disease (Gene: chromosome 4)(Gene: chromosome 4)- Insidious onset: Usually 40-50- Insidious onset: Usually 40-50- Choreic movements in onset- Choreic movements in onset- Frequently associated with- Frequently associated with emotional disturbancesemotional disturbances- Ultimately, grotesque gait and sever- Ultimately, grotesque gait and sever dysarthria, progressive dementiadysarthria, progressive dementia ensues.ensues.
HUNTINGTON’S CHOREAHUNTINGTON’S CHOREA