FILE copy

ecor U. $. DEPARTMENT OF

HEALTH. EDUCATION. AND WELFARE October 9, 1962

Vol. XIV, No .. 20 NATIONAL INSTITUTES OF HEALTH

PUBLIC HEALTH SERVICE

Seaborg to Deliver The NIH Lecture On October 17

Dr. Glenn T. Seaborg, Nobel Prize-winner Chairman of the Atomic Energy Commission, will deliver the next in the series of National Jnstitutes of Health Lec­tures on Wednes­day, Octoher 17, at 8 :15 p .m. in lhe Clinical Center auditorium.

Dr. Se ab or g's s u b j e c t will b e " S t a t u s of the Transuranium Ele­ments."

These elements, Dr. Seaborg says, Dr. Seoborg constitute an exciting branch of science that had its origin at the time of World War II "and has a clearly discernible future of great promise."

The transuranium elements, he points out, are for all practical purposes synthetic in origin and must be produced by transmutation with the heavie3t natural element, w·animn.

Dr. Seaborg, lite discove rer or co­rtiscoverer of many of the trans­uranium element s, says th:it the key to their discovrry wa~ their p<1<;ition in t.he Peri-0dic Table.

(Sec DR. SEABOIW. Pail<' 6)

RNA Provides New Clue To Protein Synthesis

A new clue to the genetic fac­tors controlling protein synthesis in the human body has been noted by National lllstitutc of Mental Health researchers studying solu­ble Tiboni1cleic acid (S-RNA).

Ribonucleic acid (RNA) is known to participate in the pJ'ocess by which the genetic information carried by deoxyribonucleic acid (DNA) determine the amino acid sequence characteristic of ~ach pro­tein in the human body. Because of its relatively small molcci.;lar weight and shoTt length, S-RN A, a special type of RNA, has proYcd particularly suitable for studies of protein synthesis.

Possesses Definite Structure

Recent findings by Drs. Kilmer S. McCully and Guilio L. Cantoni of the NIMH Laboratory of Cellu­lar Pharmacology indicate that the average S-RNA molecule possesses a definite st1·ucture reproduced during synthesis in a highly spe­cific manner.

Departing from the widely held concept that all the information necessary for protein biosynthesis is transmitted from parent to daughter cell only by DNA, these observers hypothesize that S-RN A is synthesized by pathways com­pletely or partially independent of

(S,,e Nf:JV Cf,UE. Page 4)

First PHS Surgical Team Departs for South Vietnam to Aid Civi I Population

Members of the first of the surgical teams to be sent to South Vietnam to assist the civilian population spent two days at NIH as a part of their orientation program, prior to departure September 27.

The surgical te11ms, which are --------------Nation's armod forces. I t is esti­bcing recruited by the PHS D ivi-

sion of Commissioned Officer Per- mated that the ratio of physicians sonnel with the assistance of the to civilians is one to Pvc1·y 250,000. Bureau of Medical Services, will BMS is continuing to interview sc1·ve abroad with the Agency for applicants for other teams that International Development. Team members agree to serve for a 2-year period.

'l he South Vietnamese Govern-1nent requested the United States to provide the surgical teams be­cause of the scarcity of physicians, most of whom arc serving in the

will go to South Vietnam in the 11ext few mollths. The Bureau rc­pot-ts that the response to letters has been so good that it is expected every team will be manned by very competent personnel.

(Si·,• /'HS '/'HAM, f'"g" 7)

UGF Drive Launched Here; NIH Goal Is $87,640; Oct. 23 Rally Planned

The 19G2 United Givers Fund Campaign was launched here last week with the announcement of this year's goal of $87,640 and the appoint­ment of the Coordinating Committee and Institut:e and Division chair­men and vice chairmen.

Dr. Clinton C. Powell, Chief of the Division of General Medical Sci­ences, is N TH Campaign Chair­man amt Dr. Dale R. Lindsay, Chief of the Division of Research Grants, is Vice Chairman.

Dr. Powell expressed complete co11fidence in the success .of this campaign. "Although our goal is almost $5,000 more than last year," he said, "the important aspect of ~his campaign is a 100 percent participation by NIH employees.

"If NIH participation reaches 100 percent," he added, "we should have no problems in reaching our dollar quota."

Notes Close Association

A t a meetin g of the Coordinating Committee, Dr. Powell pointed out the close association of the work of NIH employees with that of the agencies supported by contribu­tions to the t;GF Campaign.

Dr. Powell named Roy Perry, Chief of the Photographic Section, Medical Arts and Photography Branch, DRS, to head the Coordi­rmting Committee beeau~e of "his excellent work in the past and in particulat· to carry forth some of the ideas of last year's campaign."

Other members of the Coorclinat-

ing Committee are Fred Caponiti, OD, prin t ing and publications; George P. Marsden, DRS, visuals; Elwyi, Meenen, DRS, construction; George T. Bury, OD, fiscal plaJ1-ning; Miclrnel F . Canning, DGMS, publicity; Robert L. Campbell, DRS, program pl:rnning; and Anne Udoff, DGMS, liaison representa­Live.

Music by Band

Tniiial plans were made at the meeting for the UGF rally to be held October 23 in the Clinical Center auditorium from 10 to 11 a.m. Featured at the rally will be the band from Walter Johnson High Sch ool, and tentatively, a group of folk singers from the sc·hool.

Weekly progi·ess of the campaign will be am1ounced by a newsletter to be distributed to all NIII em­ployees, depicting the individual In­stitute and Division goals, their percentage of this goal attained, and their percentage participation.

The Institute and Division Chair­men are Richard L. Scggcl, OD;

(Ser UGF DRIVJ•:, Pa11c 7)

At the first meeting of the Coordinating Committee, George Marsden illus­trates an idea for the theme of this year's United Givers Fund campaign at NIH. Clockwise, I. to r. : Fred Coponiti, Elwyn Meenen, Mr. Marsde n, Mike Canning, Roy Perry, Committee Chairman; Or. Clinton C. Powell, NIH Cam­paign Choirmon; Lee OeSista , and Anne Udoff.- Ph~tl;> !,y Jerry Hecht.

Page 2 October 9, 1962 THE NIH RECORD

Published hi-weekly at Bethesda, Md., by the Public Information Section, Office of Research Information, for the infor mation of employees of the National Ins titutes of Health, princi1>al research center of the Public H ealth Service, U. S. Department of H ealth, F.ducation, and ,velfare.

~ IR R ecore! Office ................................ Blclg. 31, Rm. 5841. Phone: 496-2125

Editor .... . .. .............. .... ................................. .................................... E. K. Stabler

Stoff Corresponde nts

Betty Slattery, NCI; Tony Anastasi, NHI; Kathryn Mains, NIAID; Mary Henley, NIA MD ; Marie Norris, NIDR; Lillie Bai)ey, NIMH i Pat MacPhcrson, NINDB; Elsie Fahrenthold, CC; Faye Heil, DBS; H elene Doying, DRFR; Dick Turlington, DRG; J ean Torgerson, DRS.

NEWS from

PERSONNEL X-RAY TECHNOLOGY COURSE:

The second NIH training course in X-ray technology is now in prog­ress at the Clinical Center with ftve trainees receiving classrnom instruction ancl on-the-job training in the various phases of medical

X-ray technology. These trainees, cat·efully selected

from 38 applicants, are Sandra Kay Moore, Nancy Jane Warner, Robert W. Jackson, William E. Muehlmann, and Frances R. But­ler.

Course Is Intensive This intensive 2-year tl·aining

course, under the instruction of the Chief of the Diagnostic X-ray Depai-tment and his staff, will pre­pare these trainees for a career in X-ray technology. As technicians they will perform technical duties relating to patient positioning and radiography of various parts of the body.

Upon successful completion of this course, these young men and women will qualify for the exam­ination administered by the Ameri­can Registry of X-ray Technicians. They will also qualify for employ­ment with NIH or other federal agencies, subject to e11trance on the Civil Service Register.

Applications for the third X-ray technology course, scheduled to be­gin next September, will be accept­ed beginning in January 1963. Fur­ther information is available through the Personnel Office, Clini­cal Center.

FSEE SCHEDULE ANKOUKCED The Civil Service Commission

has announced the Federal Service Entrance Examination schedule for 1963.

Applicants who have a college

Special Job Opportunities Are Listed by PMB

With this issue the Record inb·oduces a listing of Special Job Opportm1ities as an aid in ftlling certain selected posi­tions throughout the NIH. Employees are urged to follow this listing for their own in­formation and to tell friends outside the N IH of jobs of particular interest. Additional information is available from the Recruitinent and Place­ment Section, Bldg. 1, Rm. 21, Phone 496-2403.

Secretary (Steno), GS-5, to be assigned to New Delhi, I n­dia.

Secretary (Steno) , G S-6, to be assigned to Tokyo, Japan.

Position Classifiers, GS-9 or Jl. Temporary, part-time or full-time. Status required.

Messengers, GS-1. Veterans preference. Status required.

Digital Computer P 1·ogram­mer, GS-5 or 7. Mathematics background.

Instructor ( Steno-General Clerical), GS-7. Status re­quired. NIH experience pt·e­feri-ed.

education or the equivalent in ex­perience are eligible to compete in this examination. Candidates who qualify are considered for ti-ainee positions at the entrance level in a wide variety of career fields in various Federal agencies and geo­graphical locations.

A complete schedule of the w1;t. ten test dates and the categories of positions which the examination covers are listed in the FSEE an­nouncement. Copies of the an­nouncement and further informa­tion may be obtained from your Personnel Operations Officer.

Capsule-Size Lab Has Giant-Size Task Of Testing Supplies for Quality Control

About the last place the average per.son would look .for a laboratory is in the Shipping and Heceiving Room in Building 13. Yet one of the most essential labs in ).!'IH is tucked into a corner of the open room behind Platform E- the cap­su le-!;ized lab of the Supply Man­agement Branch's Quality Control Service.

This is a lab with a big fuuction -that of testing samples of the hundreds of products received here to see if they meet the high stand­al'ds required for use in N IH re­seal'ch and other activities.

List ls Voluminous

A list of the products tested regularly by the lab's staff would be too voluminous to mention. It includes such cliverse items as saw­dust for animal cages, rubber gloYeS, artists' brnshes, detergents for cleaning glassware and animal cages, dry cell batteries, surgical insttuments, clinical thermometers, glassware, slop walrhes, and even canned drinking wate1·.

Since many of the firms which supply NTH are small manufactur­ers with no inspection facilities to determine whether their products are meeting Federal specifications, the need for a testing lab at NIH was clearly indicated. Additionally, because many articles in use here are designed especially for NIH, there are no overall Federal stand­ards governing their qua! ity.

To insure uniform quality and satisfactory performance of these products, the Quality Control Serv­ire wa.~ established last year as a component of S'.\1B's Property and Supply Section.

IL is headed by John A. Hamp­ton, a civil engineer and a former

Robert Kaiser, staff chemist for the Quo lit y Control Service, weighs o sin­g le groin of detergent before testing it for woter content.-Photo by Som Silverman.

lieutenant colonel in the Ab: Force. Each of )Ir. Hampton's staff has

a specialty. His assistant, Lester Oxendine, tests food-both animal and human, metal products, and furniture. Robert Kaiser, a chemist, naturally has a wide variety of products to inspect. Glassware is the specialty of Nima Meadows, and Robert Ginsburg is an expert on the quality and performance of rubber and plastics.

If a selected sample in a ny in­coming order does not meet specifi­cations, the entire lot is rejected. Although inevitably there are some rejections, '.\fr. Hampton says that tl1e overall quality of most ship­ments of goods is sul'prisingly high.

When asked the manufacturers' reaction to the rigid inspection .system at NIH, Mr. Hampton re­plied that it was most favorable and that suggestions for improve­ments in quality were welcomed by all o.C Lhem.

Dr. G. Halsey Hunt, former Chief of the Division of General Medico! Sciences (left), is pictured with Mrs. Hunt and Dr. Jomes A. Shonnon, Director of NIH, following a s pecio l ceremony in Wilson Holl, Se ptember 27, in which Dr. Shonnon presented to him the Meritorious Service Medol of the Public Health Se rvice for superior performonce and achievement.-Photo by Jerry Hecht.

T HE NIH RECORD

Plastic Adhesive Tested For Performance in Cardiovascular Surgery

A new plastic adhesive that bonds firmly to many tissues may prove useful for controlling bleed­ing during surgery on the heart and g1·eat vessels.

The compound, called Eastman 910 Monomer, polymerizes swiftly under pressure in the presence of moisture to form an adhesive bonu. Drn. Nina Braunwald and William Awe, of the Surgery Branch, Na­tional Heart Institute, have tested this adhesive in animal experi­ments to determine whether it might serve i n lieu of sutures to stop bleeding from the heart and great vessels, to repair septa! de­fects, or to secure artificial heart valves.

Performs Well

They report in Surgery that the adhesive served extremely well in sealing holes in the aorta with muscle patches taken from the chest wal l. These seals withstood blood pressu res of 300-400 mm./ Hg without ruptm-ing, and stopped bleeding with equal effectiveness in heparinized and non-heparinized animals. It a lso perfoxmed well in repairing holes in the heart itself when the muscle patches were ap­plied to the outer surface.

P atches of porous synthetic ma­terials wern less successful than muscle patches because the adhe­sive effectively sealed the pores and prevented the ingrowth of host tis­sue .necessary for firm healing. It was also generally unsuccessful in repairing septal defects and in se­curing artificial valves because it did not adhe1ie well enough to the inner surface of the heart.

The authors conclude that al­thoug h the adhesive is unlikely to supplant sut ures in cardiovascular surgery it may vep lace sutures in situations where weakened bloo<l vessel walls or coagulation defects exist.

SMB Issues Revised Edition OF NIH Supply Catalog A new and revised edition of

the NIH Supply Catalog has just been published and <llstrib­uted by 1,he Supply Management Bra11ch.

The catalog contains over 200 moi-e illustrations than the prior edition, and descriptions of available items have been spaced out fot· easier readability.

In addition to general infor­mation, the catalog devotes a special page to the "tote" box and instructions for its return to SMB.

Additional copies of the cata­log or sets of dividers may be obtained by calli.ng Ext. 3504.

October 9, 1962

U.S.-Soviet Conferees Resume Cooperative Heart Research

Soviet and United States scientists take nates at a brie fing an National He art Institute research activities during the Russians' re ce nt visit here . Left ta right: Prof. Nadar N. Kipshidze, Director of the Institute of Thcrpy at Tbilisi, Georgia , U. S. S. R.; Prof. Aleksandr L. Myasnikov, Director of the Institute of The rapy, Academy of Medical Scie nce s, U. S. S. R., in Moscow; Prof. t~ natoli Vikhert, a clinical pathologist from the latter Institute; and Dr. Paul Dudle y White, famous U. S. cardiologist, now consultant to the Massachusetts Ge neral Hospital, Boston.-Photo by Bob Pumphrey.

Three distinguished cardiologists and a profossor of pathology from the U. S. S. R. met at NIH with a group of Amedcan scientists Septem­ber 26 for a third annual Joint Scientific Conference on Cardiovascular Disease.

Sponsored by the National Heart Institute, the conference was held under terms of the Scientific Ex­change Agreement between ihe U. S. and the U. S. S. R. for 1962-63.

The American and Soviet scien­tists discussed specific projects for cooperative research efforts be­tween the two countries.

Project Shows Promise

One project which shows much promise is the comparison of the severity of atherosclerosis of the coronary arteries and aorta in per­sons dying from natural causes in diffe1-ent population groups from the two countt-ies.

The use of a common protocol such as that suggested by the Study Group in Atherosclerosis of the World Health Organization will make the comparison of findings more meaningful.

"Such a study might p1·ovide clues to environmental or cultural patterns which may be related to the development of this disease," said Dr. Ralph E. Knutti, NHI Di-1·ector.

In the next two months the American and Soviet scientists will exchange various criteria, meth­ods, and protocols for the study. The exchange may culminate in a

meetiJ1g of the planning groups for each country in Moscow next Feb­ruary or early Sp1-ing.

Discussions of further exchange of scientific personnel resulted in plans for a fourth joint Scientific Conference for Cardiovascular Dis­ease, to be held n ext Spring in Moscow.

The first conference took place at the National Heart Institute in May 1960. The second conf.erence was held in Russia in May 1961, and was attended by seven Ameri­can cardiologists.

The AmeJ·ican scientists who participated in the i-ecent confer­ence here are Dr. Paul D. Whit e, Boston; Dr. Thomas R. Dawber, NHI, Framingham, Mass.; Dr. 1"rede1-ick Epstein, Ann Arbor; Dr. Michael Lyons, New York; Dr. Joseph Bunim, NIAMD; lJr. Ralph E. Knutti, NHI; Dr. William J. Zukel, NHI; Dr. J ohn D. Turner, NIU; Dr. Arthur E. Rikli, BSS; and Jerome Cornfield, NH!.

These men-particularly Dr. White who has made several ex­tensive trips to the Soviet Union in tho last few years- are very

(See CONF'EliEES, Page 4)

Page 3

Survey Shows Careers In Research, Teaching Attract PHS Fellows

The success of the Public Health Sen·ice'.:s fellowship program, which

began in 1938, has been freshly evaluated in a survey just published by the Division of Research Grants.

The smvey shows that a high proportion of former PHS fellows remain engaged in resea1·ch and teaching, and that most have at­tained positions of substantial re­sponsibility and trust.

Based on 1·esponse::; from 2,981 of the 3,250 recipients of fello,v­ships between 1938 and 1958, the survey presents data on the fel­lows' p1•ofe.ssional growth and geo­graphic rno,·emcnts; their appor­tionment of time between labora­tory, lecture rostrum, and admhl'­istrator's desk; and the tYJJes of organizations they serve.

6 Are Deans Of those 1,408 former fellows

whose employment is primarily aca­demic, 6 are deans; 52 are depart­ment chairmen; 203 are full p,·o­fessor.s; 373 are associate profes­sors, and 615 are assistant profes­sors.

Of 825 who I'eportoo research as a primary pursuit, 289 bear the title of research scientist, and 358 are research associates. Of 1,251 former fellows who have medical or dental degrees, 555 arc diplomate.s of specialty boards.

At least one former fellow is em­ployed in every State in the Union. Fifteen percent of the total in the survey are located in New York, and over two-fi fths of the total are in four States: New York, ?/Iassa­chusetts, California and Maryland.

Study Detailed

Considerably more detailed than earlier studies of the subject made in 1953, 1955 and 1957, the survey shows that the percentage of for­mer fellows engaged in some re­search activity is approximately 87 percent. Over 67 percent of the former fellows spend some time in teaching. Forty percent have ad­ministrative duties, and over 30 percent are in clinical practice.

l\lore than half of the respond­ents in t he survey have .some em­ployment in a medical-academic setting, i.e., school of medicine, dentistry, or public health, or in an affiliated institution. Approximately 20 percent are employed in aca­demic settings other than medical, and about 16 percent are in Federal, State, and local health agencies.

Copies of the study, Public Health Service Fellows, 1938-1958, Current Professional Status-PHS Publication No. 931- arc available without charge from the DRG In­formation Office, Bldg. 31, Rm. 1B32, Ext. 4987.

Page 4

'Toby' and 'Suz' Bowman Retire With 40 Years Combined NIH Service

With a combined total of 40 years se1·vice at NIR, Mr. and Mrs. Walter Bowman al'e retiring with­in two weeks of •each other.

Mr. Bowman retired September 30 at the age of 70, after 20 years with the Laboratory of Infectious Diseases, National Institute of Al­lergy and Infectious Diseases. Helen Susan Bowman will 1·etire at the end of this week from the Clinical Center, where she has been employed for the past 11ine of her 20 years at NIH.

As a biological laboratory tech­nician, Mr. Bowman has been offi­cially cited for supe1ior perform­ance. His l'esponsibilities in the Laboratory of Infectious Diseases involved collection and µrepara­tion of biologic specimens. An abil­ity to do outstanding work and his friendly good humor became Mr. Bowman's trademark.

Prepares Special Diets

Mrs. Bowman, a member of the Clinical Center Nutrition Depart­ment staff since its establishment in 1953, served in the special meta­bolic kitchens where food is pre­pared only for patients who are participating in metabolic bal ance studies.

Such studies have contr ibuted much pertinent information in va­rious fields of nutrition. Mrs. Bow­man's responsibilities included the prepa1·ation of special diets which require meticulous care and pre­cise measurements, and the main­tenance of accurate 1·ecords of the food and liquid consumed by each study patient at every meal.

Both Mr. and Mrs. Bowman be­came familiar and welcome figures in their work environments. Thei1·

NEW CLUE (Continu.rd from. Paut I)

DNA. It also appears that at least part of the structure of the S-RNA is either identical or very similar for widely diverse classes of or­ganisms.

The structure of S-RNA was studied through the use of Tr ribo­nuclease whfoh splits the S-RNA into small segments, at predeter­mined locations. The segment s ob­tained were identified by the use of coluJUn chromatography, u ltra­violet absorption tech11iques and hydrolysis with pul'ified snake ven­om 5'phosphodiestcrase followed by paper chromatography.

Appropriate statistical analyses showed the average S-RNA mole­cule to be arranged in a non-ran­dom manner.

A completely defined structure

October 9, l 962

Mr. and Mrs. Walter Bawman.­Phata by Lee Bragg.

friends came to 1010w them as "Toby" and "Suz."

At Christmas the Bowmans re­ceive cards from friends all over the world, including many former Clinical Center patients. They took great delight in befriending pa­tients at the CJjnical Centc1·--espe­cially those who for geographic or other reasons seldom had visitors-­and enjoyed this association fully as much as djd the patients. Christmas also usually brings a few 11101,e ash trays to add to Mr. Bowman's collection of over 100.

Life time Md. Residents

Both lifetime residents of Mary­land, the Bowmans will retire to their half-acre home outside Gaith­ersburg.

Mr. Bowman intends to spend much of his time in his workshop, building lawn furniture and other outdoor pieces-his hobby since he was a boy. Mrs. Bowman, in addi­tion to sewing for her six grand­children, wants to raise flowers now that she has more time.

The Bowmans have two sons, Robert, who lives in Connecticut, and Paul, who lives close by in Gaithersburg.

Gary Cooper Film Next In R&W Winter Series

"Friendly Persuasion," starring Gary Cooper, will be the next in the series of free movies sponsored here by th e Recreation and Welfare Association of NIH. Screenfo~s are scheduled for Saturday and Sun­day, October 20 and 21, at 8 p. rn., in the Clinical Center auditorium.

NIH employees, their guests, and CC patients are invited to attend.

for each S-RNA chain will aid in determining its amino acid specific­ity, its interaction with ribosonal RNA, and its function in recogniz­ing the biological code which di­rects the formation of amino acid sequences in proteins.

These findings a rc reported in the Journal of Molecular Biology.

CONFEREES (C<Hitinucd j rom Page .t)

much intereste<l in stimulating co­operative research efforts between the two countries.

The members of the Soviet group who visited the Heart I nstitute and NIH are Prof. Aleksandr L. Myasnikov, Director of the Insti­tute of Therapy, Academy of Med­ical Sciences, U. S. S. R., in Moi:­cow, and chai l'man of the g1·oup; Prof. Pavel E . Lukomskiy, ChiPf Ther apist at the Ministry of Health, U. S. S. R., in Moscow; and Prof. Nodar N. Kipshidzc, Di­Tecto1· of the Institute of Therapy in Tbilisi, Georgia, U. S. S. R.

Profs. Myasnikov and Kipshi­dze attended the May, 1960 con­ference at NIH. Pl'Ofessor J,ukom­skiy has not been in this country beforn.

Pathologist Joins Delegatio-,

Another Russian scientist, .Prof. Anatoli Vikhcrt, joined the three­man delegation during its stay at NIH. A clinical pathologist from the Institute of Therapy, Academy of Medical Sciences, U. S. S. R., in Moscow, he is interested in elec­tron-microscopy as it is used in the investigation of the renal aspects of hype1tension.

Prof. Vikhert has been visiting in pathology laboi·atories at NIH since September 14.

The cardiologists were welcomed to the Heart Institute on Monday morning, September 24, by Di. Knutti. They later met with Dr James A. Shannon, NIH Director, then toured N TH facilities. The tour included the Natio11al Library of Medicine, the Instrument Engi­neering and Development Branch, DRS, and the Animal Hospital, DRS.

Visit NHI Labs

On September 25, Tuesday, they visited several NHI laboratories and met v.,ith Dr. Robert Berliner, Director of NHI's Jntramurnl Re­search P1·ogrnm and his staff.

The Russian scientists were hon­ored at a luncheon the same day, attended by Surgeon General Luth­er L. Teny, Dr. Shannon, and other NIH and NHI staff. At the luncheon-held at the Bethesda Naval Officers' Club--the Surgeon General presented each visitor with a copy of the English tJ'anslation of Atherosclerosis - Occurrence, Clinical For ms, Therapy, a new review of Russian st.udies and t heories on atherosclerosis.

The review was written by Prof. Myasnikov, one of the visiting delegation.

The three cardiologists are con­tinuing their tour of U. S. research facilities, with stops ill Boston, Chicago, Rochester, Minn.; Min­neapolis, San Francisco, Houston,

THE NIH RECORfi

Dr. Goldman to Receive Methodology Award Oct. 15 in Miami

Dr. Morris Goldman, of NIAID's Laboratory of Parasitic Diseases, will r eceive the Kimble Methodol­ogy A ward on October 15 for his contributions to the evolvement of · the fluorescent

antibody t echnique as an advanced re­search method and cliagno~tic tool for rapid identification of infection-caus­ing microbes.

The award, to be presented by the State and Provin-

o,. Galdman cial Public Health Laboratory Directors at their an­nual conference in )1iami, recog­nizes work performed by Dr. Gold­man at the Communicable Disease Center in Atlanta, Ga., a Public Health Service facility. Dr. Gold­man ~erved 15 yeai·s a,t the Center before transferring to NIH. in Oc­tober or last year.

Dr. Goldman ·wil l receive an hon­orarium of $1,000 and a silver plaque. 1'he award is sponsored by the Kimble Glass Company, a sub­sidiary of Owens-Dlinois Glass Company.

Advances Treatment T ime The technique of labeling anti­

bodie.s with a fluorescent dye per­mits the laboratory investigator using a fluorescence microscope to observe the reaction which occurs when the antibody adheres to a microbe. Identifications of bacteria, fungi, and viruses that required several days by conventional meth­ods can now be accomplished in a few hours, thus s igniflcantly short­ening the time when treatment of a patient can begin.

The fundamental fluorescent anti­body technique, developed by Dr. A. H. Coons, anothe1· Kimble Meth­odology Award Winner, was ap­plied by Dr. Goldman in his work in diagnostic microbiology at a time when many obstacles stood in the way of its use.

Dr. Goldman and his associates were able to work out standardized staining techniques, evaluate chem­icals and equipment needed, and answer basic questions of procedure vital to advancing the time when the fluorescent antibody method of diagnosis could be given more wide­s pre.id tise.

Dr. Goldman is a member of the Society of Para!;-itology, the Society of Tropical Medicine and Hygiene, and the Scientific Resea.rch Society of America.

and New York. They will a lso at­tend the Fourth World Congress of Cardiology in Mexico City. They arc scheduled to return to Russia. at the end of this month.

THE NIH RECORO

New Technique Pinpoints Norepinephrine Location In Nervous System

A technique combining autorn­diography and electron microscopy has resulted in the precise localiza­tion of norepinephrine in the sym­

pathetic nervous system, thus pro­viding a basis for future studies of sympathetic nerve activity.

National Institute of Neurologi­cal Diseases and Blindness scien­tists, cooperating with National Institute of Mental Health investi­gators, have demonstrated that ra­dioactive norepinephrine, and pre­sumably endogenous norepineph­rine, are localized in those parts of the nerve axon containing small vesicles with dense central cores.

Findings Reporte d

These findings were repo-rt(xi at the F ifth International Congress for Electron Microscopy by Drs. David E. Wolfe and Keith C. Rich­ardson of the NINDB Laboratory of Neuroanatomical Sciences, co­opErrating with Drs. Julius Axelrod and Lincoln T. Potter of the NIMH Laboratory of Clinical Sciences.

In previous biochemical DH•I

pharmacological studies, the Nl M 11 scientists showed that labeled noi·e­pinephrine, when injected intrn­venously, is stored within sympa­thetic nerve axons or in ce1tain cells ( Schwann cells or chromaffin cells) closely associated with the nerves.

Coated W ith Emulsion

'l'o define the location of nore­pinephrine more p~cisely, sections of pineal gland tissue from ra.ts in­jected with labeled norepinephrine we1,e coated with photographic emulsion. These were then devel­oped and examined with light and electron microscopes.

Blackened photographic silver grains resulting from the radioac­tivity were found to be localized over .sympathetic axons Jacking a sheath of Schwann cells (nucleated satellite cells). They were only con­centrated over the poitions of the axons conLaining numerous small vesicles with dense central gran­ules.

Locoliitotion Significont

The localization of norepineph­rine is extremely significant, since these vesicles have been isolated and studied chemically, and their morphological characteristics can be determined with the electron mici-oscope. In time, such studies will increase our knowledge of the functions of the sympathetic ner­vous system and the action of drugs influencing the heart, blood ves­sels, and many other sympatheti­cally innervated regions of the body.

Attorney Gene rol Robert F. Ke nnedy pins the PHS Commissioned Corps Meri­torious Service Award emblem on the lopel of Dr. Harris Isbell, Director of the N IMH Addiction lteseorch Center, ot ceremonies in the Stote Deportment auditorium, with the Gpprovol of Dr. Luther L. Terry, PHS Surgeon General.

Dr. Isbell, NIMH, Wins PHS Award fer Work On Drug Addiction

DI'. Harrjs Isbell, Director of the NJJ\IH Adcliction Research Center at the Public Health Service Hos­pital in Lexington, Ky., received the ;\feritorious Service Award of. the PHS Commissioned Corps Sep­Lember 28 in recognition of his out­standing work in drug addiction re­search.

The presentation was made by Attorney General Robert F. Ken­nedy during the White House Con­ference on Narcotics and D1·ug Abuse held in the State Depart­ment Auditorium.

D1·. Isbell is one of the world's outstanding authorities on the ad­diciting properties of drugs, the na­ture of d1·ug addiction, and the con­duct of research into addiction problems.

On Hospitol Grounds

'l'he research center he now heads jg located on the grounds of the PHS neuropsychiatric hospital in Lexington where patients addicted to the use of narcotics receive treat­ment.

The citation reads in part: "Throughout his 1 i years as Direc­tor of the Addiction Research Cen­te1· of NL\1H, he has provided very effective scientific, intellectual and moral leade1·ship. Under his leader­ship the Center has gained world­wide recognition, not only for its work in the field of drug addiction, but also as a center for research in experimental psychiatry."

A native of Horatio, Ark., Dr. Isbell was graduated in 1934 from the Tulane University Medical School in New Orleans. He was commissioned in the Public Health Service in 1935 and became a mem­ber of the original staff of the hos­pital in Lexington.

A!ter a 5-year period in other a8signments, including nutrition studies at NIH in Bethesda, Dr.

Isbell retumecl to Lexington lo do research in drug addition in 1944. H.e was made head of lhe research center the following year.

At the Center Dr. I sbell devel­oped new and extended exis~ing methods fo1· te:.ting the addiction properties of a large number of new derivatives of morphine and synthetic analgesics. These meth­ods furnished essential information of great importance for national and international contl'ol of nar­cotics.

Develops ' Nolline Test'

In the course of these investiga­tions, Dr. Isbell devised the metha­done-substitution technic of opiate withdrawal and demonstrated the superiority of this method over a great variety of procedures in com­mon use before and proposed since that time. He also developed the "Nalline Test," designed to detect narcotic addiction, which is now used clinically.

More recently, D1'. Isbell has l'e­ceived w1iversal recognition for his original contributions to experi­mental psychiatry. He was the firsl to discovet· the rapid development of tolerance to LSD-26 and the LSD-like properties of psilocybin. His research on the interactions of LSD-25 with tranquilizers anti other similar agents are unique in the field and are of great theoretical importance.

Dr. Isbell also made important contributions in the development of new analgesic drugs with a lower addicting liability than existing drugs used for the same purposes. In addition, he has carried out im­portant studies of cross-tolerance between psychotomimetic drugs which have been major contribu­tions to psychopharmacology theory. These findings enable the investigato1· to determine which drugs have common mechanisms even though their chemical struc­ture is dissimilar.

Page 5

NIAMD Drug Authorities Attend White House Conference on Narcotics

Three NIAMD authorities on narcotics and drug addiction par­ticipated in sessions of the White House Conference on Narcotics and Drug Abuse held in Washing­ton, September 27-28.

They were Dr. Everette L. Ma.y, Chief of the Section on Medicinal Chemist1·y; Dr. Nathan B. Eddy, former Chief of the Section on Analgesics; and Dr. Joseph Cochin of the Laborato1·y of Chemistry.

The Conference was convened to reexamine the whole problem of narcotics use in this country and to define guidelines for a new com­prehensive Fede1·al narcotics pro­gram.

Work Is lnternationol

Both Drs. Eddy and May have been actively associated with prob­lems concerning adcliction-produr­ing drugs on national and interna­tional levels, and arc members of the Committee on Drug Addiction and Narcotics of the National Re­search Council, National Academy of Sciences.

Dr. Eddy, former Chaii-man and now Executive Secretary of this Committee, has also acted as panel chairman for several sessions of the Expc1t Committee on Drugs Liable to Produce Addiction, WHO, of which he and Dr. May are also members.

President Kennedy addressed the opening session of the meetings which were held in the State De­partment Auditorium. Presiding as Chairman of the Conference, At­torney General Robert Kennedy also addressed the conferees on both days of the sessions.

App1·oximately 400 authorities in various disciplines relating to nar­cotics and drug abuse were invited to participate.

Dr. Clair Gardner Named NIDR Program Analyst

Dr. Clair L. Gardner has been appointed to the newly created po­sition of Program Analyst in the National Institute of Dental Re­search. He will identify, analyze, and make proposals on matters of broad significance toward the at­tainment of objectives in the over­all dental research programs.

Dr. Gardner holds the rank of Senior Dental Surgeon in the PHS Commissioned Corps. He has s-erved as Staff Dental Office1·, Indian Health Hospital, Sisseton, S. Dak., and Assistant Chief, Dental Serv­ices, Division of Indian Health, Washington, D. C. Prior to his new appointment he was Area Dental Officer, Indian Health Area Office, Aberdeen, S. Dak.

Page 6

DR. SEABORG (Continued from Page l)

Recognizing that the trans­uranium elements represented a whole new family of actinide ele­ments analogous to the rare earth series of elements, lanthanides, Dr. Seaborg and his associal,es were able to predict their chemical prop­erties and the11cc to separate them from all the other elements in the Periodic Table.

At the present time, according to Dr. Seaborg, 11 transuranium ele­ments with a total of 11early 100 isotopes, have been created and discovered. All of these new ele­mcnbs are unstable and therefore radioactive.

The half-life of their various isotopes, he adds, generally de­creases with increasing atomic number. As heavier elements are created, they exist for decreasing periods, making their production, separation, and identification pro­gres-sively more difficult.

Discovers Other Isotopes

In addition to the discovery of transuranium elements, Dr. Sea­borg and his colleagues arc respon­sible for the identification of more that 100 isotopes of elements throughout the Periodic Table.

World-famed as a nuclear chem­ist, Dr. Seaborg became Chairman of the AEC in :March 1961. He was a member of the Commission's first General Adv:isory Committee from 1946 until 1950 and has served on the President's Science Advisory Commjttee. He has also been a member of the Joint Commission on Radioactivity of the International Council of Scientific Unions, and the Committee on Standards and Units of Raclioactivity of the Na­tional Re.search Council.

In 1951 Dr. Seaborg shared the Nobel Prize in Chemistry with Prof. E. :M. McMillan of the Uni­versity of California and in 1959 won the AEC's Enrico Fet·mi Award for his outstanding work in the field of nuclear chemistry and for leadership in scientific and edu­cational affairs.

Nomed Outstanding

Among other honors, he was named one of the 10 ouLstanding young men in the United States by I.he U.S. Juniot· Chamber of Com­merce in 1947, and in the same year received the American Chemical So­ciety's Award in Pure Chemistry.

Dr. Seaborg has served on the faculty of the University of Cali­fornia since 1939. He is currently on leave of absence from his post as Professor of Chemistry.

In 1942 he was granted leave of absence to head the plutonium work of the Manhattan Project at the University of Chicago. When he returned to the University's Chem­istry Department in 1946 he was given rMponsibility for direction

October 9, 1962

R & W President James B. Davis, Chie f, Supply Monogement Branch, 0 0 Cleft), presents the NIH Softball championship trophy to Ooryl Wigle, captain of the winning PIQnt £n9ineerin9 Br11nch t e11m (right), GS Justin Smith, PEB, President of the Softball Leogue o nd o member of the winning teom, d isplays one of the individual trophies oworded.-Photo by Bob Pumphrey.

Luncheon Caps NIH Softba II Season; Engineers Defeat NIAMD in Playoff

'l'he third N IH Intramural Soft­ball season ended September 19 with a luncheon and award of h'Ophies by James B. Davis, Presi­dent of the NIH Recreation and Welfare Association, to the winning Plant Engineering Branch team and to second and third place teams.

Thit-ty-two attended the noon­time affair the day following the Engineers' tight 2-1 playoff v:ictory over NIAlHD. Members of the win­ning team, captained by Daryl Wigle, received individual trophies. The mnner-up NIAMD team and the NHl and NlNDB squads which tied for third place received team trophies.

Pitches 3-Hitter

Pitcher Jerry Duvall of Plant Engi11eering twirled a three-hitter for the winners, struck out five, and scored the win11ing run in the top of the final inning on a hit by George Grubbs.

However, Duvall had to survive a last ditch rally by an NIA.MD team which was seeking its second

of the Lawrence Radiation Labora­tory operated for the A.EC by the University.

A native of Ishpeming, Mich., Dr. Seaborg received his Pl1.D. de­gree from the University of Cali­fornia in 1937.

He is a member of Phi Beta Kappa, an Honorary F ellow of the Chemical Society of London and of the Royal Society of Edinburgh. He is a Fellow of the American Insti­tute of Chemists, the Ne\\' York Academy of Sciences, the California Academy of Sciences, the American Physical Society, and the American Association for the Advancement of Science.

straight championship. He struck out Ken Jones ,vith the potential tying and winning runs on second and third for the final out of the exciting game.

The Engineers and NIA'..\ID had tied for first place in the l 0-team loop during the regular season with 13-3 records.

Dr. Martin Rubel, Laboratory of Clinical Science, XIMH, pitched for the losers and allowed only one hit and two unearned rUlls. He struck out 2.

Winning Teom l isted

Members of Lhe winning team were Ross Holliday, J erry Duvall, John Wood, E. "Moe" Saffell, Jus­tin Smith, Joe J\ifaceira, George Grubbs, Wayne Ohler, Charles Loomis, Norman Jones, Frank Jackson, L. Lee Manuel, Posey Howell, Daryl Wigle, Alfred Dud­ley, Elwyn l\leenen, Harold Bur­gress, and Al Perkins.

Team captains Andrew Perry, NIAMD; Dr. Herbert Weissbach, NHI; and Norman Mills accepted the trophies for the second and third place teams.

He is al.so a member or the American Chemical Society, the American Nuclear Society, the American Academy of Arts and Sciences, the American Philosophi­cal Society, the Royal Swedish Academy of Engineeril1g Science, the Royal Society of Arts (Eng­land), and the Amedcan Scandi­navian Foundation.

Dr. Seaborg is the author of ap­proximately 200 scientific papers, including a number of comprehen­sive reviews and compilations in scientific publications. He is also the author or coauthor of several books on chemistry and the ele­ments.

THE 1H RECORD

Catecholamine Synthesis Is Effectively Blocked By DBO Inhibitors

Studies by National Heart Insti­tute scientists indicate that cer­tain compounds that inhibit the en­zyme dopamine-beta-oxidase ( DBO) can effectively block norepinehp­rine and epinephrine production in laboratory animals.

DBO is the enzyme that cata­lyzes the conversions of dopamine to no1·epinephrine and epinephrine. Several compounds that inhibit this enzyme effectively block the pro­duction of norepinephrine and epi­nephrine in vivo, but do not inter­fere with production of serotonin and other biologically important amines derived from dopamine.

Blocking the synthesis of these two catecholamines has great po­tential medical interest because of the role they a,ie suspected of play­ing in essential hypertension. This new family of enzyme inhibitors­the first agents found that effec­tively block the synthesis of these amines in the body-may therefore be valuable research tools.

En.,yme Fooled

These inhibitors have about the same molecular size and shape as dopamine-the substance ordinar­ily processed by DBO-but differ from dopamine in chemical st-ruc­ture. Nevertheless, the similarities are strong enough to fool the en­)>yme into taking on one of these foreign compow1ds. Having done so, the enzyme can neither convert that compound to no1,epinephrine nor easily get rid of it. The enzyme is thus put out of action. Eventu­ally, so many enzymes are tied up that norepinephrine production in the tissues is sharply curtailed.

N eed Evoluotion

Although certain of the DBO in­h_ibitors have been shown to block norepinephrine and epinephrine production in laboratory animals, the physiological consequences of that b lockade remain to be evalu­ated. Preliminary studies also in­dicate that the present crop of in­hibitors are far too toxic to war­rant serious consideration as po­tential therapeutic agents.

The NHI studies were made by Drs. Carolynne Hirsch, Ronald Kuntzman, Erminio Costa, and Bernard B. Brodie, of the Labora­tory of Chemical Pharmacology; and by Drs. B. Nikodijevic, Cyrus R. Creveling, and Sidney Uden­friend, of the Laboratory of Clini­cal Biochemistry.

The DBO inhibitors used in the studies were synthesized and sup­plied to NHI by E. M. Bavin, of Smith & Nephew, Ltd., England, and Warne1:-Lambert Research In­st.ilute, Morris Plains, N. J.

THE NIH RECORD

PHS TEAM (Continued from Page 1)

During its two days at NIH the 6-man team, which is especially in­terested in tropical medicine, par­ticipated in discussions of the fol­lowing subjects by NIH staff mem­bers : "Tropical Dermatology," by Dr. William E. Clendenning of the Dermatology Branch, NCI; "Para­sitic Diseases,'' by Dr. Donald E. Kayhoe, Head of the Medkal and Surgical Groups Section of the Cancer Chemotherapy National Service Center; "Tropical Bacte­rial Disea ses," by Dr. Norman B. McCullough, Chief of the Labora­tory of Bacterial Diseases, NI AID; and "Malaria," by Dr. G. Robert Coatney, Chief of thll Laboratory of Parasite Chemotherapy, NIAID. The team also attended a labora­tory session conducted by Deaner K. Lawless of the Laboratory of Clinical Investigations, NTAID.

The first team, which left a week ago last Thursday, will be sta­tioned in Can Thor, a city serving half a million people, situated 90 miles from Saigon.

Members of the team are Dr. Martin Donelson, Jr., a former Navy physician who has been a

UGF DRIVE (Con.ti1rncd from l'aoc 1)

J . Gordon DuBay, DRS; Dr. George A. Hottle, DBS; Dr. Gordon H. Seger, DGJ\IS; Dr. Dale R. Lindsay, DRG; Dr. Donald S. Fredrickson, NHI ; D r. Martin D. Young, NI AID; Dr. Francis A. Arnold, N IDR; Dr. Rjchard H. Williams, NIMH; Dr. Richard L. Ma.slant\, NINDB; Dr. )1ichael B. Shimkin, NCl; Dr. G. Donald Whedon, NIA~1D; Daniel )1c11onagle, DRFR; and Dr. Clif­ton K. Himmelsbach, CC.

The Vice Chairmen are Howard E. Kettl, OD; Margaret Root, DRS; Betty Henn igan, DBS; Lucille R. Watts, DG:\IS; Harold W. Cunan, DRG; Linda-Ann Jenks and Eliza­beth Wiehlc, NHI; Jay W. Seering, N TAID; John E. Fitzge1,ald, NIDR; H. B. Ragas, NIMH; Eckart Wipf, NJNDB; Eileen Young, NCI; Clair E. Lacey, NIAJ\1D; Richard Kesslei·, DRFR; and Margal'et A . Badger, cc.

This year 143 health and welfare agencies in the National Capital area will be .supported wholly or in part by the Uniled Givers Fund. Se1·vices provided by these agencies include such basic programs as care for homeless and neglected children, counseling on personal and family problems, hospital care, legal help, rehabilitation of the physically handicapped, and care for the aged.

Other UGF agencies work on the prevention, as well as the cur<!, of physical, mental, and social ills.

Oclober 9, 1962

Members of the first PHS surgicol teom to be sent to South Vietnam ottend o lob session conducted by D. K. Lawless, NIAID, in which he is assisted by Barbaro Belton. Left to right: Dr. Mortin Donehon, Jr., Teom Surgeon; Mr. Lawless, Kenneth A. Ebe rt, Nurse Anesthet ist; Dolores Isabelle Alloy, Surgical Core Nurse; Mrs. Belto,.,, Olevia Cunninghom, Medical Technologist; Dr. Rob­e rt E. G. Norton, Assistant Surgeon; ond Barbara Joon Palubicki, Operating Room Nurse.-Photo by Bob Pumphrey.

private surgeon in Danville, Va., for the past several years-Chief Surgeon; Dr. Robe1t E. G. Nor­ton, of PHS, recently with the U. S. Coast Gi1ard at its Academy in New London, Conn.-Assistant Surgeon; Kenneth A. Ebert, from Langlade County Memorial Hos­pital, Antigo, Wis.-Nurse Anes-

List of Latest Arrivals Of Visiting Scientists 9/10-Dr. Peter A. Plack, United

Kingdom. Sponsor, Dr. Mickel.son, NIA)ID, Bldg. 10, Rm. 9D20.

9/13-Dr. Sven Ove Strand, Swe­den. Sponsor, Dr. Steinberg, NHT, Bldg. 10, Rm. 5N309.

9/13-Dr . .Katsumi Tanabe, Ja­pan. Sponwr, Di·. Witkop, NTAl\fD, Bldg. 4, Rm. 228.

9/18-Dr. Hans Ericsson, Swe­den. Sponsor, Dr. Williams, CC, Bldg. 10, Rm. 4D41.

9/18-Dr. Peter Uniled Kingdom. Berendes, NIXDB, Rm.4A02.

Owen Yates, Spon.sor, Dr. Robin Bldg.,

9/20-DI'. Clive Bradbeer, United Kingdom. Sponsoi·, Dr. SLadLman, NHI, Bldg. 3, Rm. 217.

9/21-Dr. Arieh Yaron, Israel. Sponsor, Dr. Sober, NCI, Bldg. 6, Rm. 216.

9/25-Di·. Thomas J. Bat.lerham, Australia. Sponsor, Dr. Weiss, NIAMD, Bldg. 2, Rm. Bll.

9/25- Dr. Masanosuke Tak1gi, Japan. Sponsor, Dr. Mutayama, NIAMD, B ldg. 4, Rm. 318.

9/26--Dr. Bhuwan C. Joshi, India. Sponsol", Dr. Sargent, NIAMD, Bldg. 4, Rm. 211.

9/26-Dr. Reinhard Sarges, Ger-many. Sponsor, Dr. Witkop, NIAMD, Bldg. 4, Rm. 228.

9/27-Dr. Michael A. Beaven, United Kingdom. Sponsor, Dr. Brodie, NHI, Bldg. 10, Rm. 7N117.

thetist; Rarbara J. Palubicki, oper­ating room supervisor in the Chi­cago PHS Hospital-Operating Room Nurse; Dolores I. Allay, a private duty nurse from New York City-Surgical Caro Nm·se; and Olevia Cmmingham, of the I'HS Outpatient Clinic, Washington, D. C.-Medical T-echnologist.

First NIH Staff Fellows Named in New Program

The first group of appointees un­der the NIH Staff Fellowship Pro­gram inaugurated by Dr. James A. Shannon, Director of NIH, was re­cently ann<iunced.

This program offers young scien­tists thE' opportunity of working here as NIH staff members Ior an initial fellowship pet·iod of two years, in which they ,,ill acquire professional research experience under the direction or senior in­vestigators.

Fellows who demonstrate lalenls that can be utilized here will be encouraged to apply for appoin~ ments in either lhe Civil Service or the PHS Commissioned Corps.

As the ]lrogram expands to meet $Lafling needs, the number of Staff Fellow., is expected to increase.

The first of the appointees, al-1·eady on duty 01· rlue to report soon, a:1d their areas of assignment are:

Drs. l\1arie Joy Mason and John T . BadP1·, NCI; Judith Levin and Charles L. Goodrick, NHI; Theo­dore S. T hco<lore, NTAfD; James D. Connolly, Charles L. Coulter, Joel lrarbus, and Peter L. Workman, N IAllID; Joseph Bossom, Basil J. Sherlock, and J oan Snyder, NI:VJH.

The haves and have nots can often be traced back to the dids and the did nots.- D. 0. Flynn in the Saturday Evening Post.

Page 7

Dr. Janney Is Appointed Chief of NIMH Program For Career Development

Dr. Robert H. Felix, Director of the National Institute of l\1ental Health, has announcPd the appoint­ment of Dr. Harold :\1. J anney, lVleclical Director of the Bureau of Prisons, Depart­ment of Justice, as Chief of the Nii\:1H Career Develop­ment })rogr am.

The Career De­velopment P r o -gram, inaugurated in 1960 under the direction of Dr. Stanley F. Yolles, ND1H Associate Dr. Janney Director for Extramural Programs, is designed to provide advanced training for doctors who are inter­ested in careers as psychiatrists in the Public Health Service.

Training is available at the U. S. Public Health Service Hospital in Lexington, Ky., and at United States universities and hospitals offering approved training pro­grams in psychiatry.

Is Commissioned Officer

Dr. Janney has been a member of the PHS Commissioned Corps since December 1936. His first assign­ment was with the Federal Re­formatory in Chillicothe, Ohio, where he served as a staff medical officer unti l August 1953 when he joined the Bureau of I'risons.

There he was responsible for di­recting, developing and supervising medical, surgical, psychiatric, nurs­ing, and related rehabilitntion pro­gram.s for 24,000 prisoners in 30 penal and correctional institutions in lhe United State~.

Dr. Janney is a Visiting Lecturer at the George Washington Institute of Correctional Administration. His many speeche:; and publications cover a wide field of medical and psychiatric care in Federal prisons and training programs iJ1 psychia­try.

He received his l\LD. degree fl,om L ouisiana State Medical School in 1935 and interned at Charity Hos­pital in New Orleans.

Maginnis in NCI Post ; Nye Is CC Successor

Willard W. :.\faginnis, SuperY;sor of the Clinical Center's Normal V<il­unteer Patient P:rog,-am, has been appointed to the post of Program Analyst 111 the Contracts SecLion, Operations Branch, National Can­cer Inatitute.

Delbert L. Nye, Scnio1· Case Worker a.ssigned to Heart Social Service, CC Social Service Depart­ment, has been named )fr. Magin­nis' successor as supervisor of the CC program.

Page S

4 from N IAMD Present Research Findings at Mexico City Congress

Dr. N. Raphael Shulman, Chief of the Clinical Hematology Branch, and Dr. Victor J. Marder, Clinical Investigations; Dr. Makio M u1·a­yama, Acting Chief of the Section on Hematology; and Dr. Jules A. Gladner of t he Section on Physical Biochem istry, Laboratory of Physi­cal Biology, represented the Na­tional Institute of Arthritis and Metabolic Diseases dul'ing the an­nual meetings of the Ninth Inter­national Congress of Hematology in Mexico City, September 9-15.

At the Session on Jmmunohema­tologv Dr. Shulman and Dr. Mar­der sp~ke on "Isoantibodies against Platelets and Leukocytes." Describ­ing recently developed methods of measuring antibodies against in­herited antigens on platelots and leukocytes, the report also focused on diseases such as neonatal throm­bocytopenic purpura and leuko­penia due to maternal sensitization by these anLig·ens.

Base d on Prior Findings

The study was based on findings from previous investigations 011 the problem of antibodies against platelets, when a sensitive tech­nique-dependent on complement fixation for platelet-antibody de­tection-was developed. This re­port will be published in the Pro­ceedings of the Ninth International Congress of Hematology.

Addressing the Session on Bio­chemistry, Dr. Murayama spoke on "'A Sub-Molecular Mechanism of Sickle Cell Formation." Based on recent investigations of t.he con­form at i o 11 a 1 (architectural) changes in the hemoglobin mole­cule, this repo1t prnsented addi­tional data on an underlying ac­tion of the abnormal hemoglobin when subjected to temperature-in­duccd chemical changes, as ob­served in optical rotatory disper­sion studies.

Contribute Additional Evide nce

The results of these studies­utilizing a precision-built model of hemoglobin molecule compo11ents­not only support but also contrib­ute additional evidence to previous findings on this molecular reaction in nonnal and sickle cell hemo­globin (reported in Natu1,e, June 6, 1962).

Dr. Gladner discussed the results of current studies within the Sec­tion on "The Molecular Aspects of the Fibrinogen-F ibrin Tra11sition" before the Session on Coagulation.

Presented for the first time be­fore an international g roup of hematologists, these findings stress the newly-found ro le of the pep­tides which are released during the

October 9, 1962

NIH CHILDREN RAISE MONEY FOR PATIENTS

REPRESENTATIVES OF THE CHILDREN who conducte d th is yea r' s NIH Chil­d ren 's Fair on Se ptember 1 S present the proceeds-$84.10 in a cigar box­to Dr. Jack Masur, Director of the Clinical Center, as their annual contribu­tion to the N IH Patients' Welfare Fund. The amount is nearly double last year's gift. Front row, left to right: Louise Holliday, Vice Chairman; Mork Holliday, Alexis Poul She lokov, a nd Stanley Tabor. Bock row: Richard Tabor, Marilyn Tabor, and Barbaro Sober, Chairman.-Photo by Som Si lverman,

THE N IH RECORD

World Heart Congress Hears NHI Members

Two members of the National Heart Institute staff are presenting papers at the Fourth World Con­gre..~s of Cardiology in 711e,uco City. The Congress opened Sunday and ends next Saturday.

Dr. Eugene Braunwald, Chief of the Cardiolo11;y Branch. is present­ing. two papers: "The Use of Pre­cordial Isotope-Dilution Curves in Cardiovascular Diagnosis," and "The Syndrome of Severe Mitra! Regurgitation with Normal Left A trial Pressure." Dr. William Kan­nel, Senior Surgeon of the Fram­ingham (Mass.) Heart Study, is presenting a paper entitled "Im­mediate Mortality in Coronary Heart Disease-the Framingham Study."

:\'laming and afternoon sessions are being conducted at the Con­gress, which is sponsored by the International Society of Cardiology. During morning meetings simul­taneous sessions are being held in order to be able to include at least 260 individual contributions and 15 insti tu-tion pap<'rs. Afternoon se~­sions arc being devoted to large meetings for coordinated discus­sions.

Red Cross Bloodmobile To Be at NIH Oct. 18

Miss Aber, DRFR, Receives Performance Award

The American Red Cross Blood­mobile will be in Wilson Hall on Thursday, October 18, from 9 :15 a.m. to 1 p.m.

Employees o,·er 18 and under 60 years of age are eligible to donate blood. VolunteE>rs under 21 mu,;t have written permission from a parent or guardian. Permission forms are available in Bldg. 1, Rm. 2).

Volunteer;; may donate once c,·ery eight weeks or five times a yea,·. Donors should not eat any fatty foods for at least four hours pri01· to their appointment.

Tn a memorandum to all employ­ees Dr. Shannon said: "Within the past few weeks the NIH was able to gi,·e assuTance to .several of its employees a11<I members of their families that blood would be avai l­able, without cost, at a t ime o.[ critical need. This assurance could be given only because of your gen­erosity in participating in the Red Cross Blood program .... "

conversion of fibrinogen to fibrin, as well as other aspects of the clotting reaction.

A i-ep011; on the physiological ac­tivities of these peptides ·will soon appear in the Annals of the N ew York Academy of Sciences.

As a special servicC' to delegates, the meetings featured simultaneous translations of all addresses into French, English and German.

Wilma I. Aber, Contracts Assist­ant in t he Health Resem·ch Facili­ties Branch of the Division of Re­search Facilities and Resources, received a cash award for superior performance and achievement at an in(ormal ceremony in the North Bethesda Office Center September 28.

The award was presented to l\lis~ Aber by Dr. Francis Schmehl, Branch Chief, and Gerald Sparer, Division Executive Ofl\cer, for pcr­f ormance of "a wide range of <lutie3 in an accurate and competent manner" and for "a remarkable ability for organizin11; her work, or special assignments to the Branch, and canying them out with the least amount of effort."

"The quantity of her assigned duties," t he citation added, "has never impaired the quality of her

accomplishment of them." l\Iiss Aber, a member of the In­

diana Bar Associat ion, joined the staff of Health Research Facilities in August 1956 when it was part of the Division of Re.search Grants.

Wilma Abe r receives a check for su­perior performonce from Or. Francis Schme hl.-Photo by Bob Pumphrey.

R&W Sponsors Concert by Mozart Vocal Trio The first concert in t.he 19G2-63

winter series, sponsored by the Recreation and Welfare Association of NIH, will be presented by the l\lozart Trio, Thursday, October 18, at 8:30 p.m. in the Clinical Center audi~orium.

The Trio, consisting of Lee Mereclith, soprano, and John Yard and Joseph Collins, baritones, will present a program of vocal mu.sic by Wolfgang Amad!'us Mozai't.

The repe1toire of the ensemble includes rarely printed and little known Mozart music.

The Trio has been acclaimed by critics both in this count,·y and in Europe. A,t the pre.sent time, the concert at NIH is the group's only performance scheduled for the Washington metropolitan area this season.

Admission charge is one dollal'. Tickets may be purchased from the R& W Film Desk on the Bl level of the Clinical Center and ft-om the R&W office, Bldg. 31, Rm. 1A18.

Children under 12 and CC pa­tients will be admitted free of charge but tickets must be obtained.