Boston  University  College  of  Engineering  Department  of  Biomedical  Engineering  

BME  28th  Annual  Senior  Design  Project  Conference Friday,  May  3,  2013  

Front cover photo credits – clockwise starting at top left:

Kelsey Evans, Kyle Jones, Kristen O’Leary; Diana Aksyonova, Carolynn Gaut; Cory

Haselmayer, Peter McGuirk; Jason Pui, Suraj Rama, Benjamin Szewczyk

Back cover photo credits:

David Conegliano, Jale Manzo, Emily Polson

Welcome from the Chair

It is my distinct pleasure to welcome our guests, our alumni, industry representatives, our faculty and our students to Boston University’s 28th Annual Biomedical Engineering Senior Design Project Conference. This conference has become an annual right of passage for all BU BME seniors, and culminates our year-long Senior Design Project Program. This program is recognized as a national model for the capstone independent design and communication experience for BME undergraduates, and helps us train the future leaders and innovators in bioengineering. Over the course of the day, our talented students will present their state-of-the-art design projects as they complete their BS degrees from one of the top Biomedical Engineering programs.

Biomedical Engineering synthesizes engineering, computation, math and physical sciences with the life sciences to advance our understanding of biology, physiology and medicine. This understanding is then exploited to develop new devices and methods to improve medical care. The BU BME BS degree program is one of the oldest such programs in the country. Our ABET-accredited BS degree program in Biomedical Engineering is designed to provide integrated training in life, physical, and engineering sciences as preparation for a variety of careers in bioengineering, applied biotechnology, and medicine. We also offer an Industrial Internship Program that places students in companies for up to a year.

Seniors must also engage their projects via a course called “Product Design and Innovation in Biomedical Engineering” coordinated by Professors Art Rosenthal and Tom Szabo, with guest lectures by members of our Industrial Advisory Board. The course teaches students concepts of design, intellectual property, patents, regulatory issues, and marketing, all in the context of their projects.

This year’s senior design project program was directed by Professor Irving Bigio and Professor Catherine Klapperich. Professors Bigio and Klapperich invested much energy and organizational skills to sustain the level of excellence and impact for which this program is renowned. Professor Bigio and Professor Klapperich were assisted by a team of BME faculty (Professors Mertz, Smith, Szabo, Tien, Wong and Zaman) who read, graded and commented on all written assignments, proposal drafts, oral proposal presentations and progress reports. Their efforts helped ensure that the program continued to sustain its level of excellence. I also served as part of this team and was fortunate to enjoy the program in all of its dimensions. I also want to acknowledge the assistance of Professor Joe Bizup and Lindsey Gilbert from the BU Writing Program. Finally, a very special thank you to Laura Cunningham for her sustained support and tireless efforts to coordinate all aspects of today’s program.

Our students are remarkable at rising to the challenge and I have no doubt that their presentations today will impress and entertain you. Enjoy!

Solomon R. Eisenberg, ScD Professor and Chair, Department of Biomedical Engineering Associate Dean, College of Engineering Undergraduate Programs

Research Laboratories

Auditory Biophysics and Simulation

Auditory Neurophysiology

Auditory Neuroscience

Binaural Hearing

Biomedical Microdevices & Microenvironments

Biomedical Optics

Biomicroscopy

Biomimetic Materials Engineering

Biomolecular Systems

Brain and Vision

Cabodi Research Group

Cell and Tissue Mechanics

Cell Photometrics

Cellular and Subcellular Mechanics

Collins Lab

Computational Genomics

Cortical & Computational Decoding of Speech

Frank-Kamenetskii Lab

Galagan Lab

Grinstaff Lab

Han Lab

Khalil Lab

Klapperich Laboratory for Appropriate Healthcare

Technologies

Laboratory for Advanced Biotechnology

Laboratory for Engineering Education & Development

Laboratory for Molecular and Cellular Dynamics

Matrix Mechanotransduction

Molecular Biotechnology

Nanomedicine & Medical Acoustics

Natural Sounds and Neural Coding

National Emerging Infectious Disease Lab

Pulmonary Physiology and Dynamics

Respiratory Research

Respiratory & Physiological Systems Identification

Ritt Lab

Segre Lab

Single Molecule Biophysics and Nano-Biotechnology

Smolina Group

Steffen Lab

Structural Bioinformatics

Synthetic Biology & Immune Cell Engineering

Szabo Lab

Tien Group

Vascular Interface and Microhemofluidics

Wong Lab

Research Centers

BioMolecular Engineering Research Center

Center for Memory and Brain

Center for Nanoscience and Nanobiotechnology

CompNet

Hearing Research Center

NeuroMuscular Research Center

BOSTON UNIVERSITY DEPARTMENT OF BIOMEDICAL ENGINEERING

28th

Annual Senior Project Conference

─ Friday, May 3, 2013 ─

7:15 – 8:00 AM Continental Breakfast

8:00 AM Welcome and Opening Remarks: Prof. Irving Bigio

8:10 – 10:10 AM SESSION I

PHO 206 Is it real?: Biomaterials, Tissue Models and Tissue Engineering

Session Chair: Prof. Solomon Eisenberg

Microfluidics-based Perfusion Bioreactor for Stem Cell Differentiation Thiagu Meyyappan, Alberto Purwada Pore-Cast Scaffold for Vascular Tissue Engineering Aimal Khankhel, Michael Zhang Linear Stretch Bioreactor Incorporating a Gel-Grip Mechanism Lijia Jin, Joonnyong Lee, Yujie Zhou Microfluidic Bioreactor for Assessment of Cardiac Toxicity Ayush Jain, Snehaseel Kakileti, Jake Kallarackal Errors and Artifacts Associated with the Calculation of the Intrinsic Properties of Cancellous Bone Cory Haselmayer, Peter McGuirk In Vitro Mucosal Membrane Culture Model for Drug Delivery Ulises Alvarez, John Hoang Electrospun Coaxial Fiber Meshes for Cancer Treatment Benjamin Cohen, Luka Grujic

10:10 – 10:30 AM COFFEE BREAK

10:30 – 12:30 PM SESSION IIa

PHO 206 Measurements on the

living (and previously

living) & treatments

Session Chair: Prof. Herbert Voigt

Classification of Imagined Speech Vincent Lin, Courtney Pacheco The Effect of Humeral Positioning on Glenohumeral and Subacromial Forces in a Cadaveric Model of Simulated Pitching Benjamin Hertz, Michael Wexler A Real-time Feedback System for Landing Pattern Modification of the Injured Runner Kelsey Evans, Kyle Jones, Kristen O'Leary Creating Virtual Environments by Recording and Analyzing Typical Everyday Listening Situations Kristian Thomas, Robert Tona Characterization Device for Esophageal Atresia Surgeries Katherine Marcaccio, Kelsey Petersen CPAP Machine for Treating Childhood Pneumonia in Developing Countries Patrick Carney, Veronica Faller, Luai Zakaria, Developing a Diagnostic for Syphilis in Resource-limited Settings Jo-ann Loh, Gregory Njus

10:30 – 12:30 PM SESSION IIb

PHO 203 Small Stuff: Molecules,

Cells and Nanothings

Session Chair: Prof. Michael Smith

Ultrasound Contrast Agents as Theranostics for Atherosclerosis Diana Miniovich, Anna Cristina Shivers System to Assess Cancer Cell Morphology with Scattered Light John Gawedzinski, Kripa Patel, Hussan Shareef siRNA-Microbubble Conjugates for Ultrasound-Mediated siRNA Delivery Obiananma Nwokike, Elaine Steranka Targeted Nanoparticles for Sustained Intracellular Drug Release David Conegliano, Jale Manzo, Emily Polson Genetic Modification of Brain Cells Using Non-Viral Methods Fiona Raso, Alexander Yoon Semiconductor Nanosensor for Cancer Fingerprinting – Diagnosis and Monitoring Daniel Kim Visual Detection of Emerging Pathogens Krista Rochussen, Meghan Schreiner

12:30 – 1:10 PM LUNCH

1:10 – 3:10 PM SESSION IlIa

PHO 206 Through a glass darkly:

Imaging Large and Small

Session Chair: Prof. Thomas Szabo

Engineering Size and Shape Specific Nanoparticles for Computed Tomography Contrast Agents Christopher Fan, Trong-Huy Vo, Allen Yen Binary Probe for Fluorescent Detection of Nucleic Acids in Live Cells Iris Kao, Angelica Ochoa AlternaGel: The Alternative Ultrasound Gel for Resource-Limited Settings Suvomita Ghosh, Sydney Moy Cell Phone Based Phase Contrast Imaging Ana Sofia Camacho, Michael Francis, Douglas Webster Design and Development of a Fast MRI Pulse Sequence for the Quantification of Tissue Iron in vitro and in vivo Robert Dalgarno, Soon Bin Kwon, Ashley Stein Design of a Flow Chamber Compatible with Traction Force Microscopy Bhumica Amin, Varuna Rao, Jennifer Ryan Design of an Image Processing System to Improve Measurement of Cellular Traction Forces Diana Aksyonova, Carolynn Gaut

1:10 – 3:10 PM SESSION IlIb

PHO 203 Small rivers: Microfluidics

Session Chair: Prof. Catherine Klapperich

Development of Microfluidic Devices for Microscale Chemical Reactions Saeed Ahmed Microfluidic Chip for Thyroid Cancer Diagnosis Lena Liu, Matthew Scott Design and Characterization of an Integrated Microfluidic System for Sample Concentration and Extraction Rebecca LaCroix, Michelle Wong Ultrasonic Filtering and Detection for Microfluidic Devices Andrew Beckenbach, Brittany Culpepper, Anjanesh Venkatesh Integration of Microfluidics with Multiplexed Plasmonic Biosensors John Barrett, Erik Frazier, Dylan Stevens Optimization of a Polyolefin Surface for the Immobilization of Biotin Chun Hin Tang, Jeanne Tran Blood Glucose Monitoring System for Use in Developing Countries Socrates Boutsikaris, Shannon O'Neill

3:10 – 3:25 PM COFFEE BREAK

3:25 – 5:20 PM SESSION IV

PHO 206 We Have the Technology: high-tech solutions to real problems

Session Chair: Prof. Irving Bigio

Design of Noninvasive Technology for Real-time Estimation of Hyolaryngeal Kinematics for Videogame Control Emily Bonazelli, Lynne Messina Design and Testing of a New Nebulizer Andreas Kapfhammer, Christopher Lim Stochastic Resonance Ankle Brace for Improving Balance Corey Kronman, Bhavesh Patel Mobility Aid for the Blind Christian Dorman, Ghassan El Kara, Ralph Sayad Making Robots Roam: Interface Between a Biologically Inspired Goal Directed Navigation Model and a Robot Tariq Bugrara, Collin Neill Making Robots See: Development of a Robotic Visual Sensing Module for Biologically Inspired Goal Directed Navigation Matthew Kramer, Sean Manton Reconfigurable Endoscopic Capsule Minibots Using Modular Assembly Jason Pui, Suraj Rama, Benjamin Szewczyk

5:20 PM Final Conference Comments and Award Presentations:

Prof. Irving Bigio, Prof. Solomon Eisenberg

5:40 PM Conference Reception - PHO 906

BOSTON UNIVERSITY DEPARTMENT OF BIOMEDICAL ENGINEERING

28th

Annual Senior Project Conference

─ Friday, May 3, 2013 ─

Current & Recent

Conference

Attendees

3M

Accenture Life Sciences

Advanced Instruments, Inc.

AltraBio

Altran

Applied Medical Resources

ArQule, Inc.

Atrium Medical

Avedro, Inc.

BD Medical

Beth Israel Deaconess Medical Center

BioTrove, Inc.

Boston Engineering

Boston Medical Center, Department of Clinical Engineering

Boston Scientific

Boston University School of Management

Boston University School of Public Health

Brandeis University

Brigham and Women's Hospital

Broad Institute

Bruker Daltonics

CAE Healthcare

Center for Global Health and Development

Charles Stark Draper Laboratory

Children’s Hospital Boston

CIMIT

CKD Associates

Clark & Elbing LLP

Cleveland Clinic

Codman Neuro, Johnson & Johnson

Columbia University, College of Physicians and Surgeons

Comprehensive Health Management Inc.

ConforMIS, Inc.

Covidien

Cynosure

Davol - C.R. Bard, Inc.

Decision Resources

DEKA Research and Development Corporation

DePuy Spine, Inc.

DocBox, Inc.

Draeger Medical Systems, Inc.

Eastman Kodak Company

Eaton-Peabody Laboratory

Elm Electrical & Automation

EndoCore

Essex Orthopedics & Optima Sports Medicine

Fellers Snider et al.

Fraunhofer USA-CMI

GE Healthcare

Gems Sensors

Genzyme Corporation

Goodyear-Veyance Technologies, Inc.

Harvard Business School

Harvard Medical School

Harvard University

Harvard-MIT Division of Health Sciences and Technology

Hologic

Iandiorio Teska & Coleman

Image Stream Medical

Integra LifeSciences

iWorx Systems, Inc.

JH Technologies

Johnson & Johnson

Lux Research

Massachusetts Eye and Ear Infirmary

Massachusetts General Hospital

Massachusetts Institute of Technology

Medtronic, Inc.

METI

Minnesota State University, Mankato

National Instruments

Navinet

Neuroptix Corporation

NuOrtho Surgical, Inc.

Optasia Medical, Inc.

O'Shea Getz PC

Parexel

Perceptive Informatics

Pfizer

Philips Healthcare

Praxis Advisors LLC

Pulmatrix, Inc.

Raytheon

Respiratory Motion, Inc.

Sapient

Schepens Eye Research Institute

Solace Therapeutics, Inc.

St. Jude Medical

Teleflex Medical

Ten15Ventures

Toxikon Corporation

Tufts University

UMASS

University of Texas at Austin

University of Wisconsin-Madison

US Army Institute of Environmental Medicine

USA Research Institute of Environmental Medicine

VA Boston Healthcare System

Vantage Management Group

Vertex Pharmaceuticals

Veterans Administration

Veterans Affairs Boston Healthcare System

Worcester Polytechnic Institute

Wyss Institute for Biologically Inspired Engineering

Xcellerex

BOSTON UNIVERSITY DEPARTMENT OF BIOMEDICAL ENGINEERING

28th

Annual Senior Project Conference

─ Friday, May 3, 2013 ─

Technical Advisors

& Faculty Profiles

2013 Senior Design Project Technical Advisors

Student Team Technical Advisor(s)

_______________________________________________________________________

Session I

Thiagu Meyyappan, Alberto Purwada Joyce Wong Aimal Khankhel, Michael Zhang Magali Saint-Geniez, Joe Tien Lijia Jin, Joonnyong Lee, Yujie Zhou Ali Khademhossein, Joe Tien Ayush Jain, Snehaseel Kakileti, Jake Kallarackal Ali Khademhossein, Catherine Klapperich Cory Haselmayer, Peter McGuirk Ara Nazarian Ulises Alvarez, John Hoang Xue Han Benjamin Cohen, Luka Grujic Mark Grinstaff

Session IIa

Vincent Lin, Courtney Pacheco Barbara Shinn-Cunningham Benjamin Hertz, Michael Wexler Ara Nazarian Kelsey Evans, Kyle Jones, Kristen O’Leary Michael Rainbow, Jim Collins Kristian Thomas, Robert Tona Steve Colburn Katherine Marcaccio, Kelsey Petersen Leia Stirling, Jim Collins Patrick Carney, Veronica Faller, Luai Zakaria Muhammad Zaman Jo-ann Loh, Gregory Njus Muhammad Zaman

Session IIb

Diana Miniovich, Anna Cristina Shivers Joyce Wong John Gawedzinski, Kripa Patel, Hussan Shareef Irving Bigio Obiananma Nwokike, Elaine Steranka Tyrone Porter David Conegliano, Jale Manzo, Emily Polson Tyrone Porter Fiona Raso, Alexander Yoon Xue Han Daniel Kim Raj Mohanty, Shyam Erramilli Krista Rochussen, Meghan Schreiner Irina Smolina

Session IIIa

Christopher Fan, Trong-Huy Vo, Allen Yen Xin Zhang Iris Kao, Angelica Ochoa Irina Smolina, Natalia Broude Suvomita Ghosh, Sydney Moy Muhammad Zaman Ana Sofia Camacho, Michael Francis, Douglas Webster Jerome Mertz Robert Dalgarno, Soon Bin Kwon, Ashley Stein Hernan Jara Bhumica Amin, Varuna Rao, Jennifer Ryan Michael Smith Diana Aksyonova, Carolynn Gaut Michael Smith

Session IIIb

Saeed Ahmed Aaron Beeler, Catherine Klapperich Lena Liu, Matthew Scott Catherine Klapperich Rebecca LaCroix, Michelle Wong Mario Cabodi, Catherine Klapperich Andrew Beckenbach, Brittany Culpepper, Anjanesh Venkatesh Thomas Szabo John Barrett, Erik Frazier, Dylan Stevens Hatice Altug Chun Hin Tang, Jeanne Tran Cassandra Smith Socrates Boutsikaris, Shannon O’Neill Jose Gomez-Marquez, Catherine Klapperich

Session IV

Emily Bonazelli, Lynne Messina Cara Stepp Andreas Kapfhammer, Christopher Lim Bela Suki,

Corey Kronman, Bhavesh Patel Leia Stirling, Jim Collins Christian Dorman, Ghassan El Kara, Ralph Sayad David Mountain Tariq Bugrara, Collin Neill Michael Hasselmo, Lucia Vaina Matthew Kramer, Sean Manton Micahel Hasselmo, Barbara Shinn-Cunningham Jason Pui, Suraj Rama, Benjamin Szewczyk Seung-Schik Yoo, Irving Bigio

TIMOTHY A. BARBARI

Associate provost for graduate affairs; Professor of Biomedical Engineering. BS – Colorado School of Mines, MS – UC Berkeley, PhD – UT Austin. Research Interests: Biomaterials,

hydrogels, membranes, biomolecular transport and binding, biosensors

IRVING BIGIO

Associate Chair of Graduate Programs for Biomedical Engineering; Professor of Biomedical Engineering, Electrical & Computer Engineering and Physics. BS, MS, PhD - University of Michigan. Research Interests: Medical

applications of optics, lasers and spectroscopy; biomedical optics and biophotonics; biomolecular dynamics; applied spectroscopy, especially to biomedical problems; nonlinear optics; quantum electronics; laser physics.

H. STEVEN COLBURN

Associate Chair of Undergraduate Programs for Biomedical Engineering; Professor of Biomedical Engineering; Director of the Hearing Research Center. BS, MS, PhD – Massachusetts Institute of Technology. Research Interests: Measurement

and modeling of binaural hearing performance; speech intelligibility in complex sound environments; the effects of hearing impairments on binaural abilities.

JAMES COLLINS

Professor of Biomedical Engineering; University Professor; William F. Warren Distinguished Professor; Investigator, Howard Hughes Medical Institute. BA - College of the Holy Cross; PhD - University of Oxford. Research Interests: Synthetic biology; systems

biology; antibiotics.

EDWARD DAMIANO

Associate Professor of Biomedical Engineering. BS, PhD – Rensselaer Polytechnic Institute; MS – Washington University. Research Interests: Integrated

cellular and extracellular biomechanics; biofluid dynamics; microchemofluidics; non-Newtonian rheology; closed-loop blood-glucose regulation.

CHARLES DELISI

Dean Emeritus; Metcalf Professor of Science and Engineering; Professor of Biomedical Engineering and Physics. BA - City College of New York; PhD - New York University. Research Interests: Developing and

applying computational/ mathematical methods and high throughput experimental methods to analyze changes in gene and protein expression profiles of cells in response to various endogenous and exogenous signals.

CARLO DE LUCA

Professor of Biomedical Engineering and Electrical & Computer Engineering; Research Professor of Neurology; Director of the NeuroMuscular Research Center. BA - University of British Columbia; MS - University of New Brunswick; PhD - Queens University. Research Interests: Motor control of

normal and abnormal muscles; innovative technology for monitoring and analyzing surface EMG signals.

MICAH DEMBO

Professor of Biomedical Engineering. BS - Allegheny College; PhD - Cornell University. Research Interests: Statistical

mechanics in biological systems; cell information processing and signal transduction; thermodynamics and mechanics of cell adhesion; biophysics of cell deformation; active motility.

Primary Faculty

SOLOMON EISENBERG

Associate Dean for Undergraduate Programs; Chair and Professor of Biomedical Engineering; Professor of Electrical & Computer Engineering. BS, MS, ScD – Massachusetts Institute of Technology. Research Interests: Electrically-

mediated phenomena in tissues and biopolymers; cartilage biomechanics; computational modeling of electric field distributions in the human thorax and heart during defibrillation.

MAXIM FRANK-KAMENETSKII

Professor of Biomedical Engineering. MS, PhD - Moscow Physical Technical Institute; ScD (IVth degree) - Institute of Chemical Physics, USSR Academy of Sciences. Research Interests: DNA structures;

DNA topology; DNA functioning; PNA (peptide nucleic acid).

JAMES GALAGAN

Associate Professor of Biomedical Engineering; Associate Director of Systems Biology; Associate Director of Microbial Genome Analysis. BS – University of California, Davis; PhD – Massachusetts Institute of Technology. Research Interests: Developing

efficient and accurate methodologies for the analysis of genomic data, with a particular focus on infectious diseases; computational biology; genomics; microbiology.

MARK GRINSTAFF

Professor of Biomedical Engineering and Chemistry. BA - Occidental College; PhD - University of Illinois, Urbana-Champaign. Research Interests: Biomaterials;

tissue engineering; drug delivery; macromolecular chemistry and engineering; self–assembly; nanodevices.

XUE HAN

Assistant Professor of Biomedical Engineering. BS - Beijing University; PhD – University of Wisconsin, Madison. Research Interests:

Neurotechnology; optical neural modulation; optogenetics; neural prosthetics; neural network dynamics; brain rhythmns; neurological and psychiatric diseases; cognition.

ANDREW JACKSON

Professor of Biomedical Engineering. BS, MS - University of Nevada; PhD - University of Mississippi Medical School. Research Interests: Respiratory

physiology; respiratory mechanics; role of airway closure in asthma.

SIMON KASIF

Professor of Biomedical Engineering. BS - Tel Aviv University; MS, PhD - University of Maryland. Research Interests: Computational

biology; computational functional and comparative genomics; biotechnology; algorithm design; bioinformatics; computer-aided biology.

AHMAD KHALIL

Assistant Professor of Biomedical Engineering. BS – Stanford University; MS, PhD – Massachusetts Institute of Technology. Research Interests: Synthetic biology;

systems biology; programmable microfluids; transcription regulation; mechanobiology; single-cell analysis; single-molecule biophysics.

CATHERINE KLAPPERICH

Associate Professor of Biomedical Engineering and Mechanical Engineering. MS – Harvard University; PhD – University of California, Berkeley. Research Interests:

Nanomechanics of hydrated biomaterials; gene expression in cells at the cell-biomaterial surface; microfluidic device design.

KENNETH LUTCHEN

Dean; Professor of Biomedical Engineering. BS - University of Virginia; MS, PhD - Case Western Reserve University. Research Interests: Airway and lung

tissue mechanics and ventilation; computational modeling of structure-function relations in the lung; mechanical ventilation; integrated biomechanics of the lung; linear and nonlinear systems identification.

AMIT MELLER

Associate Professor of Biomedical Engineering. BS – Tel Aviv University; MS, PhD – Weizmann Institute of Science. Research Interests: Employing

nanopore force spectroscopy to study RNA unfolding and re-folding kinetics; DNA switches and transcription initiation kinetics; RNA helicases activity; mapping of transcription factors interactions with DNA; ultra-fast DNA sequencing.

JEROME MERTZ

Professor of Biomedical Engineering and Physics. BA - Princeton University; PhD - Université Paris VI and University of California, Santa Barbara. Research Interests: Development and

application of new optical microscopy techniques to biological imaging.

DAVID MOUNTAIN

Professor of Biomedical Engineering; Research Professor of Otolaryngology. BS – Massachusetts Institute of Technology; MS, PhD - University of Wisconsin. Research Interests: Auditory

information processing; sensory biophysics; computer simulation; biomedical electronics; biomedical signal processing; environmental engineering.

JASON RITT

Assistant Professor of Biomedical Engineering. BS – Oberlin Conservatory; MA, PhD - Boston University. Research Interests: Neuroscience of

sensorimotor behaviors; biological active sensing; functional role of embodiment in neural computation; brain-machine interfaces; neural prosthetics.

Darren Roblyer

Assistant Professor of Biomedical Engineering. BS – Johns Hopkins; PhD – Rice University. Research Interests: Optical

Functional Imaging, Diffuse Optics, Near Infrared Spectroscopy, Monitoring of Emerging Targeted and Cytotoxic Therapies in Oncology, Non-Invasive Monitoring of Tumor Metabolism.

KAMAL SEN

Director of Graduate Admissions for Biomedical Engineering; Associate Professor of Biomedical Engineering. BA - Bates College; MA, PhD - Brandeis University. Research Interests: Neural coding of

natural sounds; hierarchical auditory processing; neural discrimination; population coding of natural sounds; learning in single neurons and auditory networks.

BARBARA SHINN-CUNNINGHAM

Professor of Biomedical Engineering and Cognitive & Neural Systems. BS – Brown University; MS, PhD – Massachusetts Institute of Technology. Research Interests: Auditory

attention; spatial hearing; neuro-electric imaging; neural coding; plasticity and learning in auditory tasks.

CASSANDRA SMITH

Professor of Biomedical Engineering, Biology and Pharmacology. BA, MS - West Virginia University Medical School; PhD - Texas A&M University. Research Interests: Molecular

biotechnology; genomics; schizophrenia; breast cancer twin studies.

MICHAEL SMITH

Assistant Professor of Biomedical Engineering. BS - University of Memphis; MS, PhD – University of Virginia. Research Interests:

Mechanotransduction via the extracellular matrix; fibronectin structural biology; engineered cell culture platforms for regulating cell behavior in vitro.

DIMITRIJE STAMENOVIC

Associate Professor of Biomedical Engineering. Dipl. Ing - University of Belgrade; MS, PhD - University of Minnesota. Research Interests:

Respiratory mechanics; cellular mechanics; rheology of soft tissues and cells; mechanics of foam-like structures.

BELA SUKI

Professor, Biomedical Engineering. MS, PhD - Jozsef Attila University. Research Interests: Mechanical

properties of living tissues; the ensemble behavior of complex biological systems; nonlinearities in biological systems.

JOE TIEN

Associate Professor of Biomedical Engineering. BS – University of California, Irvine; MA, PhD – Harvard University. Research Interests:

Vascularization of biomaterials; quantitative physiology of engineered tissues; biomaterials for microsurgical applications; lymphatics and interstitial transport.

LUCIA VAINA

Professor of Biomedical Engineering; Research Professor of Neurology. MS, University of Timisoara and Urbino; PhD – Universite Paris I (Pantheon-Sorbonne); Doctorat d’Etat es Sciences and Medecine (Neurologie) – Institut National Polytechnique de Toulouse. Research Interests:

Computational visual neuroscience; neuronal mechanisms underlying spatial representation; visual motion perception; perception and action.

SANDOR VAJDA

Professor of Biomedical Engineering; Director of the Biomolecular Engineering Research Center. MS - Gubkin Institute; MS - Éötvös Lorand University; PhD - Hungarian Academy of Science. Research Interests:

Scientific, primarily optimization, computational chemistry and biology (including protein and peptide structure determination); protein engineering; drug design.

Emeritus Faculty

HERBERT VOIGT

Professor of Biomedical Engineering; Associate Research Professor of Otolaryngology. BA – City College of New York; PhD – Johns Hopkins University. Research Interests:

Auditory neurophysiology; neural circuitry; neural modeling.

JOYCE WONG

Associate Professor of Biomedical Engineering. BS, PhD – Program in Polymer Science and Technology, Massachusetts Institute of Technology. Research Interests: Biomaterials;

tailoring cell-material interfaces for drug delivery and tissue engineering applications; direct, quantitative measurement of biological interactions.

WILSON WONG

Assistant Professor of Biomedical Engineering. BS - University of California Berkley, PhD – University of California Los Angeles. Research Interests: Systems biology

of cancer; cell adhesion and migration in 3D environments; cellular mechanics; applications of biomedical engineering in the developing world.

MUHAMMAD ZAMAN

Assistant Professor of Biomedical Engineering. PhD - University of Chicago. Research Interests: Systems biology

of cancer; cell adhesion and migration in 3D environments; cellular mechanics; applications of biomedical engineering in the developing world.

CHARLES CANTOR

Professor Emeritus of Biomedical Engineering and Pharmacology. BA - Columbia University; PhD - University of California, Berkeley. LOA, CSO Sequenom Research Interests: Human genome

analysis; molecular genetics; new biophysical tools and methodologies; genetic engineering.

TEMPLE SMITH

Professor Emeritus of Biomedical Engineering. BS - Purdue University; PhD - University of Colorado. Research Interests: Syntactic and semantic

structure of the genetic information in biomolecular sequences, structures and their evolution.

DMITRI BEGLOV

Research Assistant Professor of Biomedical Engineering. MS, PhD - Moscow Institute of Physics and Technology, Moscow. Research Interests: Computational

chemistry and biology; protein and function; computational characterization and prediction of biomolecular interactions

NATALIA BROUDE

Research Professor of Biomedical Engineering. BS, MS – Moscow State University; PhD, DSci – Institute of Bioorganic Chemistry, Moscow. Research Interests: Functional

genomics; genome-wide methods for genome studies; bacterial internal organization.

MARIO CABODI

Research Assistant Professor of Biomedical Engineering. MS – Imperial College of Science and Technology; PhD – Cornell University. Research Interests: Micro and

nanofabrication applied to biomedical engineering problems.

DANIEL EHRLICH

Research Professor of Biomedical Engineering. BS, PhD – University of Rochester. Research Interests: Optics;

lithography; biosensors and biomolecular assays, with a current emphasis on microfluidic instruments for high-content, high-throughput cell-based assays and deep-UV imaging.

EVAN EVANS

Professor of Biomedical Engineering. BS, MS - Rensselaer Polytechnic Institute; PhD - University of California, San Diego. Research Interests: Nano-microscale

mechanics; ultrasensitive force probes and extreme resolution optical techniques; material properties of cellular structure; role of structural forces in cell biochemistry.

EVAN EVANS

Professor of Biomedical Engineering. BS, MS - Rensselaer Polytechnic Institute; PhD - University of California, San Diego. Research Interests: Nano-microscale

mechanics; ultrasensitive force probes and extreme resolution optical techniques; material properties of cellular structure; role of structural forces in cell biochemistry.

ODED GHITZA

Research Professor of Biomedical Engineering. BS, MS, PhD – Tel Aviv University. Research Interests: Decoding speech

using neuronal oscillations; hierarchical neuronal oscillators and the basis of cortical computation; analysis of MEG signals recorded while performing a speech perception task; predicting consonant confusions in noise; modeling damaged cochleae using speech-governed methologies.

DIMA KOZAKOV

Research Assistant Professor of Biomedical Engineering. MS – Moscow Institute of Physics and Technology; PhD – Boston University. Research Interests: Macromolecular

recognition; networks of signaling protein-protein interactions; druggability of genomes; protein design.

ARTHUR ROSENTHAL

Professor of Practice in Translational Research in Biomedical Engineering; Director for the Coulter Translational Partnership Program. BS – University of Connecticut; PhD – University of Massachusetts. Research Interests: Design,

development, marketing and entrepreneurship in biomedical engineering.

Professional and Research Faculty

IRINA SMOLINA

Research Assistant Professor of Biomedical Engineering. BS, MS – Moscow Institute of Physics and Technology; PhD – Institute of Bioorganic Chemistry, Russian Academy of Science. Research Interests: Exploring the

possible use of biological and synthetic DNA analogs for applications in bioengineering, molecular imaging and single-molecule analysis.

THOMAS SZABO

Research Professor of Biomedical Engineering; Research Professor of Mechanical Engineering. BS – University of Virginia; MS – University of Rochester; PhD – University of Bath. Research Interests: Medical imaging;

diagnostic ultrasound; tissue characterization; transduction; biomedical signal processing; wave propagation; nonlinear acoustics.

Affiliated Faculty

CHRISTOPHER CONNOR

Assistant Professor of Biomedical Engineering; Assistant Professor of and Director of Research for the Department of Anesthesiology. BA, M.Eng – Cambridge University; PhD – Massachusetts Institute of Technology; MD – Harvard University. Research Interests: Applying the

principles of minimally-invasive medical engineering, physiology and information technology to clinical issues in anesthesiology.

DOUGLAS DENSMORE

Assistant Professor of Biomedical Engineering and Electrical & Computer Engineering. PhD – University of California, Berkeley. Research Interests: High-level

languages for synthetic biology; data exchange standards for biological parts and devices; system-level design of embedded systems; computer architecture; design for test.

THOMAS EINHORN

Professor of Biomedical Engineering; Chairman and Professor of Orthopaedic Surgery. MD – Cornell University Medical College. Research Interests: Hip and knee

replacement and reconstructive surgery; treatment of metabolic disease; stem cell surgery for avascular necrosis of the hip and knee; nonunion fractures.

SHYAMSUNDER ERRAMILLI

Professor of Biomedical Engineering and Physics. BS – University of Pune; MS – Indian Institute of Technology; PhD – University of Illinois. Research Interests: Biological physics.

BENNETT GOLDBERG

Professor of Biomedical Engineering, Electrical & Computer Engineering and Physics. BA – Harvard University; MS, PhD – Brown University. Research Interests: High-resolution

4Pi microscopy; microring resonator biosensors; numerical aperture increasing lens microscopy (NAIL); optical properties of carbon nanotubes; resonant cavity imaging biosensor (RCIB).

LEE GOLDSTEIN

Associate Professor of Biomedical Engineering, Psychiatry, Ophthalmology, Neurology, Pathology and Laboratory Medicine. BA – Columbia University; MD, PhD – Yale University. Research Interests: Laser diagnostics;

experimental pathology; translational neuroscience; molecular biology; biophotonics; radiobiology; biometallomics; Alzheimer’s Disease; Down Syndrome; neurodegeneration; ethnopharmacology.

STEPHEN GROSSBERG

Professor of Biomedical Engineering, Mathematics and Psychology; Founding Chair and Wang Professor of Cognitive & Neural Systems; Director of the Center for Adaptive Systems. BA – Dartmouth College; MS – Stanford University; PhD – Rockefeller University. Research Interests: Vision; audition;

language; learning and memory; reward and motivation; cognition.

FRANK GUENTHER

Professor of Biomedical Engineering, Speech, Language, and hearing Sciences; Associate Director for Graduate Program for Neuroscience. BS – University of Missouri-Columbia; MS – Princeton; PhD – Boston University. Research Interests: Theoretical

modeling with behavioral and neuroimaging experiments to characterize the neural communication underlying speech and language

JAMES HAMILTON

Professor of Biomedical Engineering, Biophysics and Physiology; Research Professor of Medicine. BS – Juniata College; PhD – Indiana University. Research Interests: Novel

approaches to biomedical problems by integrating physical-chemical and physiological/biochemical approaches complemented with molecular modeling, molecular biology and other cell biology methods.

ALLYN HUBBARD

Professor of Biomedical Engineering and Electrical & Computer Engineering. BS, MS, PhD – University of Wisconsin. Research Interests: Auditory

physiology; experiments and modeling; neurocomputing; VSLI in biomedical applications; biosensors; VLSI design using analog and digital techniques in CMOS; neural net chips, smart sensor chips, chips with biological applications; models of the peripheral auditory system.

LAERTIS IKONOMOU

Assistant Professor of Biomedical Engineering. BA – Aristotle University of Thessaloniki, Greece; PhD – Université catholique de Louvain, Belgium. Research Interests: Lung

developmental biology; lung epithelial lineage specification; development of new platforms for stem cell expansion and differentiation.

W. CLEM KARL

Professor of Biomedical Engineering and Electrical & Computer Engineering. BS, MS, PhD – Massachusetts Institute of Technology. Research Interests: Statistical signal

processing; multidimensional and multiscale signal and image processing; biomedical signal and image processing.

NANCY KOPELL

Professor of Biomedical Engineering, Mathematics and Statistics; Co-Director of the Center for BioDynamics. PhD – University of California, Berkeley. Research Interests: Applied

mathematics and dynamical systems.

ELISE MORGAN

Associate Professor of Biomedical Engineering and Mechanical Engineering. BS – Stanford University; MS, PhD – University of California, Berkeley. Research Interests: Mechanical

behavior of biological materials; mechanical stimulation of tissue differentiation; micromechanics of multiscale media; damage mechanics.

HAMID NAWAB

Professor of Biomedical Engineering and Electrical & Computer Engineering; Research Professor for NeuroMuscular Research Center. BS, MS, PhD – Massachusetts Institute of Technology. Research Interests: Computational

signal processing; applied artificial intelligence; analysis algorithms for EMG signals; analysis algorithms for patient activity signals; analysis algorithms for auditory signals.

MATTHEW NUGENT

Professor of Biomedical Engineering, Biochemistry and Ophthalmology. BA, PhD – Brandeis University. Research Interests: Response of

tissues to injury and disease; design and use of polymer-based controlled drug delivery systems; tissue engineering; the development of computational models of dynamic biological processes.

TYRONE PORTER

Assistant Professor of Biomedical Engineering and Mechanical Engineering. BS – Prairie View A&M University; PhD – University of Washington. Research Interests: Ultrasound-

enhanced transport of drugs and genes across cell membranes; tissue response to acousto-mechanical forces at the biomolecular level.

DANIEL SEGRÉ

Assistant Professor of Biomedical Engineering, Bioinformatics and Biology. MS – University of Trieste; PhD – Weizmann Institute of Science. Research Interests: Evolutionary

dynamics of biological networks, in particular the interplay between response to genetic and environmental perturbations, genomic-level functional organization and optimal adaptation.

EUGENE STANLEY

Professor of Biomedical Engineering, Chemistry, Physics and Physiology; Co-Director of the Center for Polymer Studies; University Professor. BA – Wesleyan University; PhD – Harvard University. Research Interests: Application of

statistical physics to understanding and preventing diseases related to protein misfolding, such as Alzheimer’s Disease; econophysics.

MARTIN STEFFEN

Assistant Professor of Biomedical Engineering, Pathology and Laboratory Medicine. BA – Dartmouth College; PhD, MD – Stanford University. Research Interests: Tools of systems

biology for mammalian cells; technique of mass spectrometry; identifying post -translational modifications; characterizing proteomic differences.

CARA STEPP

Assistant Professor of Biomedical Engineering and Speech, Language and Hearing Services. SB – Smith College; SM – Massachusetts Institute of Technology; PhD – Harvard-MIT Division of Health Sciences & Technology. Research Interests: Quantum optics

and imaging; photonics; fractal stochastic processes; information transmission in biological sensory systems.

MALVIN TEICH

Professor Emeritus of Biomedical Engineering, Electrical & Computer Engineering and Physics. BS – Massachusetts Institute of Technology; MS – Stanford University; PhD – Cornell University. Research Interests:

Quantum optics and imaging; photonics; fractal stochastic processes; information transmission in biological sensory systems.

SELIM ÜNLÜ

Associate Dean of Research & Graduate Programs; Professor of Biomedical Engineering and Electrical & Computer Engineering. BS – Middle East Technical University; MS, PhD – University of Illinois, Urbana-Champaign. Research Interests: Optical

characterization and nanophotonics (OCN); near-field optical microscopy and spectroscopy of semiconductor materials and devices; biosensors.

YU (BRANDON) XIA

Assistant Professor of Biomedical Engineering, Bioinformatics and Chemistry. BS – Peking University; PhD – Stanford University. Research Interests: Computational

structural biology; computational systems biology; molecular and network evolution; bioinformatics algorithms and applications.

KATHERINE ZHANG

Assistant Professor of Biomedical Engineering and Mechanical Engineering. BEng, BEco – Tsinghua University; MS, PhD – University of Colorado, Boulder. Research Interests: Mechanical

behavior of soft biological tissue; cardiovascular mechanics; multiscale modeling of biological composites; micro-and nanomechanics of thin film and thin film devices.

BOSTON UNIVERSITY DEPARTMENT OF BIOMEDICAL ENGINEERING

28th

Annual Senior Project Conference

─ Friday, May 3, 2013 ─

SESSION I

Is it real?:

Biomaterials, Tissue

Models and Tissue

Engineering

Microfluidics-based Perfusion Bioreactor for Stem Cell Differentiation

Thiagu Meyyappan and Alberto Purwada

Embryonic stem cells (ESCs) are capable of self-renewal and differentiation into various somatic cell types, potentially resulting in treatments that can replace damaged tissue or organs within the body. But the optimization of any stem cell differentiation protocol that recapitulates the various milestones of embryonic development can be challenging. This is illustrated by the effort to derive lung/thyroid progenitors from ESCs, which is complicated by the low induction efficiency and the lack of information about the best timing for each of its many induction steps. It is hypothesized that one reason for the low differentiation efficiency is the presence of cell-secreted factors that can influence the induction process through paracrine or autocrine signaling. A microfluidics-based perfusion bioreactor chip with single pass medium flow was used to continuously remove endogenous signaling molecules, add nutrients and discard metabolic wastes. This microbioreactor chip contained several cell culture chambers for culturing cells with independent fluid flow. Since the overall protocol can be further optimized by adjusting the timing for growth factors addition, an automation platform was constructed by combining solenoid valves and a programmable syringe pump. A program was written to automate multistep differentiation protocols by directing media flow from various media storage containers into the chip at different time points. This project resulted in several main findings. The use of a PDMS chip for culturing cells did not seem to deter cell viability, as cells were found to proliferate and express the appropriate differentiation markers. Gene expression analysis of these cells showed that cells that were cultured statically on our chip showed greater expression of specific lung/thyroid progenitor markers in comparison to cells that were cultured using multi-well plates. The microbioreactor chip was characterized using a rhodamine dye and the resulting data suggested that total medium replacement could be performed in mere hours. The cells that were cultured on the chip under perfusion for several days showed no signs of contamination, maintained substrate attachment, and exhibited the appropriate differentiation marker. The software for the automation platform allowed the user to add multiple commands, with each command line corresponding to a unique combination of media type, fluid flow rate, and duration of perfusion. Based on these findings, we have shown that culturing and differentiating stem cells under perfusion flow can be feasibly done with our microbioreactor chip. In conclusion, we have designed a microfluidic stem cell culture platform and an automation system that can be combined into an exciting tool for basic stem cell research and regenerative medicine. Future studies are needed to understand the relationship between fluid flow, seeding density, and gene expression.

Pore-Cast Scaffold for Vascular Tissue Engineering

Aimal H. Khankhel, Michael H. Zhang Transplantation of engineered vascular grafts has emerged as a potential new solution for cardiovascular disease treatment. While large diameter grafts are currently in use, thrombus formation prevents small-diameter grafts (<5 mm) from clinical application. Currently, electrospinning is considered the gold standard for scaffold construction. However, poorly controlled pore dimensions allow the migration of endothelial cells (EC) into the scaffold through large gaps, making it difficult to achieve formation of a monolayer. Here, we present a method to cast a thin porous non-thrombogenic film as a scaffold for vascular grafts. By pouring a poly(ε-caprolactone) (PCL) solution onto a silicon wafer and removing it upon polymerization, a film with pores replicating that of the wafer features was obtained. To reduce thrombosis, we coated the film with the surface integrin Arg-Gly-Asp (RGD). Controlling for pore size and geometry allowed us to prevent cell migration into the scaffold and induce cell alignment along the long axis of the pores. These techniques could prove useful in preventing blood-scaffold interaction, which will reduce the risk of thrombogenesis when implanted in vivo.

Linear Stretch Bioreactor Incorporating a Gel-Grip Mechanism

Lijia Jin, Joonnyong Lee, and Yujie Zhou

For many global phenomena such as heart attack and ruptured ligament or tendon,

tissue engineering for alternative tissue replacements remains the goal of many

researchers. Multiple types of bioreactors have been introduced to meet the need for

culturing various types of tissues and tissue scaffolds, but only a few designs have

achieved high consistency in operating with soft gel samples. We present a low-cost

linear stretch bioreactor with high efficiency and consistency in gripping hydrogel

scaffolds and other gels of similar physical properties. Furthermore, the design allows

for easy mounting of the samples, easy assembly, and programmable stepper motor

drive input for automatic operation. The system as a whole is compact, and can be

autoclaved. It is our hope that this design will be successful in culturing gel samples

seeded with cardiomyocytes and could become an affordable alternative to the

commercial products in the market.

Microfluidic Bioreactor for Assessment of Cardiac Toxicity

Ayush Jain, Sneh Kakileti, Jake Kallarackal Cardiovascular safety is one of the most prominent factors to consider when developing pharmaceutical treatments. To avoid excess developmental costs and wasted time spent on a drug that may later be recalled, an earlier and more accurate assessment of the drug’s cardiac toxicity is required. The objective of this project was to develop a device to monitor cardiac cells response to applied drug treatments by detecting the cardiac biomarker, troponin. A microfluidic environment was constructed that resembles in vivo cardiovascular conditions. This environment was created by designing and fabricating a polydimethylsiloxane (PDMS) microfluidic chip with long narrow culture channels to simulate conditions found within blood vessels. Various channel dimensions and designs were tested to determine the most effective and suitable scheme to maintain cell proliferation and ensure correct beating patterns of cardiomyocytes. A sandwich enzyme-linked immunosorbent assay (ELISA) was validated and tested off-chip by capturing known troponin concentrations that determined a calibration curve between fluorescence intensity and antigen concentration. The sandwich enzyme-linked immunosorbent assay was applied on-chip for the capture and detection of troponin released by cardiac cell samples. This on-chip troponin assay can be used to detect significant increases in troponin concentration as cell samples shift from a healthy to unhealthy state. By increasing the sensitivity of detection, this bioreactor can improve the efficiency of preclinical trials for drug development.

Errors and Artifacts Associated with the Calculation of the Intrinsic Properties of Cancellous Bone

Cory Haselmayer, Peter McGuirk

Cancellous, or trabecular bone network, is a highly porous material comprised of many smaller elements in the form of plates and rods. The irregular microstructure of trabecular bone determines the stiffness and strength of trabecular bone samples. Due to the complexity of the trabecular bone network, the intrinsic properties of bone samples are often underestimated when performing traditional finite element analysis (FEA) and mechanical testing. As a consequence of this underestimation, the quantitative effects on bone strength and stiffness from osteoporosis and other degenerative bone diseases are not fully understood. To accurately determine the intrinsic properties of bone samples, we have written a program in MATLAB which uses micro Computed Tomography (µCT) images of bone samples to characterize the organization of individual trabecular plates and rods. With this information the absolute number of plates and rods could be counted in the bone matrix, a new measurement of trabecular bone composition. The bone connectivity was used in FEA to find a global stiffness matrix determined by displacement of individual element connections. Volumes were sampled from the computational model and strength tested to find a relationship between bone composition and stiffness. Specifically, we sought to calculate plate and rod density from the absolute number of plates and rods to determine if there was a relationship between plate or rod density and stiffness in a sample.

In Vitro Mucosal Membrane Culture Model For Drug Delivery

Ulises Alvarez, John Hoang

P-glycoprotein (p-gp) is an ATP dependent efflux pump that is expressed in endothelial cells located on the blood brain barrier. P-gp’s broad substrate specificity serves as a defense against foreign molecules, but it limits the ability to transport therapeutic medications to the brain. The objective of this study is to suppress the p-glycoprotein pump in primary nasal epithelial cells to enable enhanced transnasal drug delivery to the central nervous system. The cells were cultivated from five different patients and then dosed with varying concentrations of p-gp inhibitor medication. The dose response and epithelial toxicity were then quantified by measuring the accumulation of Calcein AM, a fluorescent dye that is also a substrate of p-gp. Enzyme Linked Immunosorbent Assays (ELISAs) were also performed to confirm the data obtained by the accumulation assay. The results showed that Calcein AM retention in cells that had been dosed with inhibitor medication was significantly higher than in cells that had not been treated with inhibitor medication. Optimal results were obtained with Zosuquidar, a third generation p-gp inhibitor, which resulted in a 35.7% (p < .05) increase in fluorescence with the lowest dose concentration (.63 μM). We additionally identified Itraconazole, a common antifungal agent, as a potential p-gp inhibitor in nasal mucosa. Therefore we have shown that p-gp is both present and functional in nasal epithelial cells and is sensitive to both known second and third generation p-gp inhibitors as well as to Itraconazole.

Electrospun Coaxial Fiber Meshes for Cancer Treatment

Benjamin Cohen, Luka Grujic The prevention of tumor recurrence is a major challenge for modern medicine. Post-surgical systemic chemotherapy has proven ineffective for many types of cancer, and a long-term, location specific treatment is needed. In this study, we have designed and built a spinneret capable of producing coaxial polymer fibers featuring distinct core and shell regions. Using the process of electrospinning, porous solid meshes were formed consisting of coaxial fibers. Different meshes were spun by varying the flow rates and needle gauge for both the core and shell solutions as well as the applied spinning voltage. We have successfully spun fibers composed of a hydrophobic PCL (polycaprolactone) shell containing the polysaccharide dextran in the core. Evaporation of the solvents during spinning results in a final mesh that is hydrophobic and composed of hollow, coaxially structured fibers. Additionally, meshes containing fibers with diameters ranging from the micro-to-nano scale were spun. These results show that hydrophilic molecules can be electrospun successfully within a hydrophobic polymer shell, and the possibility of forming a drug loaded, coaxial fiber mesh exists. This method of drug delivery can be directly implanted onto the surgical site of tumor removal and will provide the ability to control the rate of drug release for long term prevention of tumor recurrence.

BOSTON UNIVERSITY DEPARTMENT OF BIOMEDICAL ENGINEERING

28th

Annual Senior Project Conference

─ Friday, May 3, 2013 ─

SESSION IIa

Measurements on the

living (and previously

living) & treatments

Classification of Imagined Speech

Vincent Lin, Courtney Pacheco

Patients with classical Locked-in Syndrome suffer from near-complete voluntary muscle paralysis, only retaining their ability to blink and vertically move their eyes. For this reason, most methods of communication for these patients are limited to eye tracking and eye blinking. However, using the eyes to communicate is often time consuming, frustrating, and exhausting for the patient, particularly if it requires typing with them on a virtual keyboard or blinking to answer yes-no questions. One alternative means for patient communication is a non-invasive brain-computer interface (BCI) that translates imagined speech to words on a computer screen using electroencephalography (EEG), a non-invasive technique that measures electrical activity along the scalp caused by the synchronous firing of many neurons. The goal of this project was to investigate the feasibility of such a system by exploring how accurately single-trial EEG signals produced during imagined speech could be decoded. For this project, we recruited eight healthy subjects with normal hearing and analyzed their evoked-response potentials (ERPs) directly elicited from hearing a closed set of three speech tokens, each made up of a different number of syllables (/2/, /7/, and /11/). The processed ERPs were used to train a support vector machine (SVM) that differentiated between different heard speech tokens using pattern recognition. Preliminary SVM results show that, for all subjects, neural responses can be decoded to estimate which token was presented from the closed set of speech tokens, enabling us to investigate the possibility of decoding imagined speech. The same approach to investigating heard speech was used to explore the feasibility and accuracy of decoding imagined speech, where subjects were asked to imagine speaking the speech tokens as opposed to hearing them. In this case, the induced-response potentials (IRPs) directly elicited from imagining the same set of three speech tokens were analyzed. For all subjects, performance for imagined speech was statistically better than chance (25%), suggesting that with training, determining which of a closed set of speech tokens a patient imagines speaking may be decoded from single-trial EEG. This prospect of interpreting imagined speech has a wide range of potential for communication where visual or auditory communication is undesirable or impossible.

The Effect of Humeral Positioning on Glenohumeral and Subacromial Forces in a Cadaveric Model of Simulated Pitching

Benjamin Hertz, Michael Wexler

Various shoulder injuries, including Subacromial Impingement Syndrome, result in painful conditions and are often experienced by high performance athletes that participate in overhead arm motions. Past studies have examined the isolated glenohumeral joint and subacromial space contact pressures, but they have not specifically studied glenohumeral motion and its interactions with the scapula, thorax, or forces in the subacromial space in a dynamic nature. We have designed a novel testing apparatus to investigate the effects of humeral and scapular positioning. The scapula and humerus were mounted to programmable robotic axes that provide 7 degrees of freedom without any constraints. Kinematic translation from infrared bone clusters and applied forces on a 6-axis load cell were measured. Contact pressure in the subacromial space was tested under various conditions: (1) intact, (2) capsular plication, (3) decompressed capsule, (4) and slit rotator interval, and glenohumeral joint contact pressure was measured during (5) active loading to fully represent the model along different stages. Our team successfully implemented the apparatus and performed initial testing on an isolated cadaveric shoulder as proof of principle. Our results will allow for the testing of a full cadaver with both pinned and unpinned shoulders to incrementally validate the results generated by the model and investigate uninhibited scapulothoracic motion. The model promises to provide clinically relevant data of intact, simulated injury, and repaired cadaveric specimens with further experimentation. Injury and pathology mechanisms can be better defined and surgical repairs can be evaluated to select the method best suited for a patient.

A Real-time Feedback System for Landing Pattern Modification of the Injured Runner

Kelsey Evans, Kyle Jones, Kristen O’Leary

Running is one of the most popular physical activities in the United States and around the world. Unfortunately, the health benefits of running, such as weight-control and reduced risk of cardiovascular disease, can be offset by injury. Almost 80% of runners suffer from musculoskeletal injury each year. Biomechanical research has shown that high impact forces during running are a key risk factor for musculoskeletal injury. One method to reduce these impact forces is to train runners to convert from a rear-foot strike landing (RFS) pattern to a forefoot strike (FFS) pattern. At the Spaulding National Running Center, clinicians use barefoot running to transition chronically injured runners’ landing patterns from a RFS pattern to a FFS pattern. Currently, feedback on strike patterns is delivered to patients via motion capture systems or high-speed video. However, current motion capture systems are expensive and require extensive setup, and high-speed video results cannot be administered in real-time. The goal of our project was to design a low-cost, wireless device that provides real-time feedback to runners who are barefoot. Our system measured the accelerations of the foot, used this data to determine the foot-strike pattern, and delivered visual feedback to runners on their landing patterns. In a validation experiment, we tested the strike classification system against the “gold standard” motion-capture system. We determined the sensitivity and specificity of identifying rearfoot strikes was determined to be 94.4% and 68.3%, respectively. Overall, a cost-effective alternative to the gold standard was developed that has the potential to provide effective real-time feedback to patients in a clinical setting.

Creating Virtual Environments by Recording and Analyzing Typical Everyday Listening Situations

Kristian Thomas, Robert Tona

Current speech intelligibility tests in the clinic do not capture the complexity and uniqueness of everyday speech environments, leading to the misdiagnosis of hearing impairments and improper prescription of hearing aids. The shortcomings of these tests arise from ignoring factors that are present in normal listening environments but not in clinical tests. These factors range from background noise to concurrent conversations to reverberation; they interact with each other, and they influence listeners' abilities to follow a conversation. To study these factors, we recorded conversations in different everyday environments including a restaurant, a study lounge, a busy sidewalk, on a subway, and at a busy intersection. Recordings were made using KEMAR, an acoustical mannequin. Recordings from these environments were then used to create a wide variety of virtual environments, audio recordings played through headphones that consist of speech recorded in a semi-anechoic environment added to the background sounds. Subjects were instructed to listen to virtual environments and change the signal-to-noise ratio (SNR) until they could understand roughly half of the conversation against different background sounds; this was achieved by changing the levels of the target speech. They were then asked to identify spoken words to verify the previously selected thresholds. Subjects selected similar speech thresholds for all environments. A variety of tasks can be performed using virtual environments to further identify differences in speech intelligibility between common background sounds. The creation of these tests provide a unique method of diagnosing hearing problems that will allow impaired listeners to choose a proper hearing tool.

Characterization Device for Esophageal Atresia Surgeries

Katherine Marcaccio, Kelsey Petersen

Esophageal atresia is a congenital defect in which separate distal and proximal pouches are formed rather than a complete esophagus. The current Foker technique used at Boston Children’s Hospital for esophageal atresia repair involves placing these pouches under external traction to induce esophageal tissue growth. Making accurate measurements of the forces currently applied to the infant’s esophagus and chest wall during esophageal atresia repair procedures, as well as determining the ideal applied force for tissue growth induction, will enable the standardization and improvement of the Foker technique. We have built and validated a bench-top model of the Foker technique to characterize a custom load cell, called a “tensiometer”, which is designed to measure the tension of the external traction sutures. After constructing the model, we performed benchmark tests with inelastic materials, and suture and tissue surrogate materials, to understand the sources and magnitude of measurement error with an external off-the-shelf load cell in the place of the tensiometer. We evaluated the measured mass with respect to independent variables such as angle of mass application and applied mass. We found that angular configuration does have a statistically significant (p<0.05) effect on the measured mass values with this bench-top model. Additionally, we found that there is minimal drift in the measured mass over a five-hour period of data collection. This benchmark collected data will be used to validate the bench-top model. The model will be used by researchers at the Wyss Institute for characterization of the proposed tensiometer design. Evaluation of the tensiometer with our validated test bench will allow the application of the tensiometer in a surgical setting, and will ultimately help to determine the ideal method for esophageal tissue growth induction.

CPAP Machine for Treating Childhood Pneumonia in Developing Countries

Patrick Carney, Veronica Faller, Luai Zakaria

Pneumonia is the primary cause of childhood mortality worldwide, killing an estimated 1.4 million children under the age of 5 years annually — more than AIDS, malaria, and tuberculosis combined. Currently, infants with pneumonia can benefit from assisted breathing facilitated by Bubble Continuous Positive Airway Pressure (bCPAP), yet the implementation of bCPAP is a challenge in low-resource settings due to financial constraints and high energy costs. We have developed a bCPAP device that uses lower cost materials than previous models, has a sustainable power source, and is calibrated for use on pediatric pneumonia patients. Our bCPAP machine is able to deliver and maintain physiologically safe flow rates and pressures to a patient. The implementation of our device could prevent thousands of unnecessary deaths each year in developing countries.

Developing a Diagnostic for Syphilis in Resource-Limited Settings

Jo-ann Loh, Gregory Njus Congenital syphilis (CS) is the severe and often life-threatening infection of a newborn through transmission of the bacterial spirochete, Treponema palladium. Access to diagnostic tests is limited in regions of high disease occurrence, resulting in untreated pregnant women unknowingly passing the infection onto their unborn children. Typical screening tests, such as the rapid plasma reagin test (RPR), are not effective for CS diagnosis because the high levels of maternal IgG antibodies present in the neonate directly after birth interfere with measurements of infant IgM if produced. Conversely, the cause of IgG and IgM production, the T. palladium antigens, i.e. TpN 15, 17, and 47, are immediately present in the patient. Therefore, the objective of this project was to design a microfluidic chip that is able to detect the presence of TpN antigens in blood obtained from the heel of a newborn. Trials were completed to determine that improved signal-to-noise ratio can be achieved using a microchromatograph separation column to filter confounding antibodies before application of a sandwich ELISA protocol with horseradish peroxidase (HRP) conjugate streptavidin to detect human IL-4, which was used as an equivalent model antigen. The filtration and detection techniques were then integrated into a microfluidic AutoCAD design. Further quality testing on a 3D printed prototype is required to improve the design by decreasing processing time and cost per chip. With continued research, this novel, robust, and highly sensitive diagnostic will quickly and cost-effectively identify both symptomatic and asymptomatic neonates who need immediate antibiotic treatment.

BOSTON UNIVERSITY DEPARTMENT OF BIOMEDICAL ENGINEERING

28th

Annual Senior Project Conference

─ Friday, May 3, 2013 ─

SESSION IIb

Small Stuff: Molecules,

Cells and Nanothings

Ultrasound Contrast Agents as Theranostics for Atherosclerosis

Diana Miniovich, Anna Cristina Shivers

Atherosclerosis, a disease characterized by the chronic accumulation of fat and scar tissue in the blood vessels, leads to calcification of the arteries and is often the underlying cause of heart failure. Although the incidence rate of the disease in America is on the rise, the current gold standard for detection is ineffective until the arteries are severely occluded or there is an onset of a medical emergency. Likewise, treatments such as oral medications lack specificity in targeting affected tissue and have a high rate of systemic clearance. The major goal of this project was to develop a theranostic drug delivery platform that enhances early detection, increases control over drug release, and is stable for post-manufacturing storage. By combining drug-loaded microbubble ultrasound contrast agents (MUCAs) with inexpensive ultrasound imaging, we demonstrated the capacity for simultaneous detection, through increased echogenicity (compared to stand-alone tissue), and controlled release of drug for treatment. More specifically, microfluidic flow focusing was used to manufacture the microbubbles providing increased control over polydispersity and thereby tuning the destruction threshold to switch from detection mode to drug release mode. When testing the threshold of microbubble cavitation, we showed enhanced ultrasound backscattering within a hydrogel vessel for a period of 90 seconds in clinical detection mode. Also, increasing ultrasound amplitude to drug release mode was shown to directly correspond to decreased vessel backscattering and thereby microbubble popping. Zeta potential analysis of microbubble stability in common formulation buffers at various temperatures confirmed room temperature 10:10:80 (glycerol:propanediol:DI) to be the ideal protocol for long term storage. Lastly, the use of conjugated fluorescent rhodamine as a model drug confirmed that our microbubble formulation was capable of uniform drug loading within the poly (ethylene glycol) layer and only released drug when the ultrasound pulse amplitude was increased above clinical detection strength. Together these results support the project goal because enhanced backscattering ultimately has the potential to discern between atherosclerotic plaques and healthy tissues. Additionally, uniform drug loading and controlled drug release improve the ability to treat only the localized area of disease. Overall, the above theranostic drug delivery platform has the potential to greatly improve the prognosis of clinical detection and treatment of atherosclerosis because it is minimally invasive, enhances early detection, and provides a more controlled drug release over the current gold standard.

System to Assess Cancer Cell Morphology Using Scattered Light

John Gawedzinski, Kripa Patel, Hussan Shareef

The micromorphology of a cell undergoes distinctive structural changes when it becomes cancerous. While some transformations can be detected through imaging techniques, mutations in smaller organelles are difficult to observe by simply viewing a sample of cells under a microscope. One way to quantitatively classify cells is to measure and compare their elastic light scattering patterns, as a cell’s gradients in refractive index depend on its architecture and biochemistry. Previous experiments in measuring cell scattering have used a polar nephelometer, a device that rotates around the sample and detects the magnitude of scattering as a function of angle. Our aim was to build and test an improved system for measuring all in-plane scattered light from a cell sample without moving parts. We constructed an apparatus that allows us to measure scattered light intensity as a function of the angle of scattering and to study how this varies in relation to different cell types. The design was engineered using a 45-degree, conical mirror, called an axicon, creating a ring of light on a CDD through confocal imaging setup. The acquisition, control and image processing for extracting angular distribution (5-175 degrees) of light are performed using an in-house developed user-friendly software. The accuracy of the design was tested using polystyrene microspheres and comparing the measured scattering with results predicted by Mie Theory. Initial testing and validation of the system with polystyrene microspheres showed considerable correlation of experimental data with phase functions predicted by Mie Theory.

siRNA-Microbubble Conjugates for Ultrasound Mediated siRNA Delivery

Obiananma Nwokike, Elaine Steranka Atherosclerosis is the hardening of the arterial wall due to accumulation of plaque, which leads to heart attacks and strokes. Small interfering RNA (siRNA) has been found to successfully knock down the expression of vascular cell adhesion molecules-1 (VCAM-1) that lead to the plaque buildup, however due to enzymatic degradation it requires packaging in vivo for safe delivery. Polyethylenimine (PEI) is a cationic polymer proven to complex and deliver siRNA but suffers from cytotoxicity and low circulation time. In this study a delivery vehicle was designed for targeted delivery of siRNA to inflamed endothelial cells using functionalized microbubbles. To decrease the toxic effects caused by the high cationic charge, and ensure greater circulation, PEI was modified with polyethylene glycol (PEG) at a 10:1 molar ratio. Our data showed that the modified PEI had a more neutral charge and experienced no aggregation when complexed with salmon DNA. Fluorescent PEG-PEI was coupled to the microbubble surface by an NHS-amine reaction, then complexed with salmon DNA. This coupling was confirmed by the increase in fluorescence when compared to control microbubbles (without amine reactive NHS-PEG) using fluorescence microscopy. The complexing of the salmon DNA was confirmed with UV absorbance. The resulting vehicle can be delivered into cultured cells using ultrasound. This project provides a non-invasive way to optimize siRNA transfection and knockdown VCAM-1 expression in endothelial cells so that complications arising from atherosclerosis can be mitigated.

Targeted Nanoparticles for Sustained Intracellular Drug Release

David Conegliano, Jale Manzo, Emily Polson Some challenges in chemotherapeutic drugs are their non-specificity and multiple drug resistance. Currently, chemotherapy involves an uncoated drug which is unable to effectively target cancer cells, affecting healthy and tumor cells indiscriminately. By coating the drug in a targeted nanoparticle, the specificity to cancerous cells can increase, thus increasing the concentration of drug inside the cancerous cell. This decreases the problem of multiple drug resistance which is caused by an overexpression of protein pumps in cancer cells that prevents intracellular drug accumulation. The conventional method to circumvent this resistance is with combinational therapy or an increased drug dosage. However, these methods do not always successfully evade the drug resistance of tumors and can lead to increased damage to healthy tissue throughout the body. We propose using a nanoparticle drug delivery system with folic acid conjugated lipids, cleavable polyethylene glycol [PEG] chains, and a doxorubicin poly-lactic glycolic acid core [PLGA]. This targeted cancer therapy allows for increased nanoparticle uptake and accumulation in cancerous cells that overexpress folate receptors. The cleavable PEG chains facilitate intracellular drug release due to their pH sensitivity to acidic conditions present inside cells. In addition, the biodegradable doxorubicin-PLGA conjugate allows for sustained release of drug, increasing its effectiveness against multiple drug resistance. Overall, with further testing we expect these nanoparticles to show increased cytotoxicity as compared to unconjugated doxorubicin/PLGA nanoparticles.

Genetic Modification of Brain Cells Using Non-Viral Methods

Fiona Raso, Alexander Yoon Gene therapy has the potential to treat patients with hereditary diseases by replacing or correcting malfunctioning genes through gene delivery. Today, viral gene delivery is the standard method to deliver DNA plasmids into living organisms, but this approach is hamstrung by several important limitations, and other nonviral methods do not translate from in vitro cell cultures to in vivo studies. In this study, we focused on synthetic alternatives for gene delivery using a lipid carrier design in a mouse model. A DAB staining protocol to recognize low expressions of proteins from the genes delivered was optimized and the pathway of the delivered genes was studied from internalization into a cell to the nucleus using fluorescence in situ hybridization. A computational method was designed using Mathematica to automate the analysis of these results. This research focused on determining optimal in vivo parameters in order to help develop a characterized analysis of the non-viral gene delivery methods by determining optimal gene delivery parameters. In conclusion, the analysis of various characteristics was used to develop an optimized synthetic carrier for efficient gene delivery in vivo.

Semiconductor Nanosensor for Cancer Fingerprinting – Diagnosing and Monitoring

Daniel Kim

Skin cancer is the most common form of cancer in the United States. Current diagnostic techniques, involving skin biopsies of suspicious moles that are identified by subjective examination using the (A)symmetry, (B)order, (C)olor, (D)ifferential Structures analysis, often lead to inaccurate or late diagnosis of melanoma skin cancer. There is a growing interest and need in nanofabricating biosensors that are capable of detecting melanoma biomarkers in patient blood samples at very low concentrations (in nM concentrations); increasing the accuracy of melanoma diagnosis at an early stage and in turn opening up available treatment options. Our approach involves fabrication of a highly specific/sensitive nanowire biosensor via photolithography and other semiconductor processing techniques. The sensors are to be functionalized with TROY antibodies and the antigen solutions. Conductance across the wires will be measured as the antigen solution is flowed over the TROY-functionalized wires. A total of 35 nanosensors have been fully fabricated, electrically characterized and are ready for TROY antibody functionalization. It is expected that the BIOFET nanosensors will be capable of detecting at least 0.1 ng/mL concentrations of TROY which confirms a successful fabrication of a highly sensitive and TROY-specific biosensor. In successfully fabricating such a sensor, opportunities to utilize this design for other biomarkers and proteins will impact the medical field by increasing detection capabilities. Higher accuracy detection of biomarkers and proteins in patient blood also opens up treatment options at earlier diagnostic stages, leading to a better clinical experience for patients.

Visual Detection of Emerging Pathogens

Krista Rochussen, Meghan Schreiner Infectious disease is one of the foremost causes of death or illness in developing countries. Infectious disease is the number one cause of death mainly because of inadequate resources and a shortage of appropriate diagnostic tools. Typically, diagnostic methods require amplification of the bacterial pathogen culture, which is both a time and labor-intensive process. Newer technologies such as real-time PCR, which enable the simultaneous amplification and detection of a targeted DNA molecule in real time, are faster in determining if bacterial DNA is present but tend to be expensive. We report a new system that detects bacterial pathogens and utilizes Peptide Nucleic Acid (PNA) technology, DNA enzyme (DNAzyme) sensor system and Rolling Circle Amplification (RCA). This method of detection has a low limit of detection and does not require elaborate laboratory equipment. The developed protocol was successful in detecting the presence of E.coli under non-denaturing and isothermal conditions in live bacterial samples. The results reported illustrate that this novel detection protocol has the potential to improve clinical diagnosis of bacterial pathogens in countries with limited or inadequate resources.

BOSTON UNIVERSITY DEPARTMENT OF BIOMEDICAL ENGINEERING

28th

Annual Senior Project Conference

─ Friday, May 3, 2013 ─

SESSION IIIa

Through a glass darkly:

Imaging Large and

Small

Engineering Size and Shape Specific Nanoparticles for Computed Tomography Contrast Agents

Christopher Fan, Trong-Huy Vo, Allen Yen

Computed Tomography (CT) has revolutionized the field of biomedical imaging by creating enhanced resolution images of biological structures using biologically inert contrast agents. However, current gold standard contrast agents are limited by their low x-ray attenuation sensitivity at CT energy levels, which is an intrinsic material property, and short blood circulation time, which is directly affected by particle size and shape. The objective of this senior design project is to address both of these limitations through novel design and bottom-up nanofabrication. With the development of anodized aluminum oxide (AAO) templates, our project aims to fabricate a scalable, cost-efficient manufacturing platform for rod-shaped hydrogel nanoparticles where therapeutic drugs or diagnostic materials can be incorporated into the hydrogel precursor. To rectify the problem associated with x-ray attenuation, tantalum-oxide (TaOx) nanoparticles were synthesized using a microemulsion technique that resulted in particles that were more sensitive at relevant x-ray energy levels compared to current gold standard contrast agents, whose sensitivity decreases at higher energy levels. To improve blood circulation time, AAO templates were fabricated using a two-step anodization process to efficiently fabricate shape specific hydrogel nanoparticle vehicles. Scanning electron microscopy (SEM) showed that this two-step anodization process could successfully create an AAO template on a quartz substrate with uniform nanopores of 60-70 nm in diameter. The successful synthesis of AAO templates and TaOx nanoparticles will produce a novel manufacturing platform for nanorod hydrogel delivery vehicles with enhanced delivery for our superior CT contrast agents.

Binary Probe for Fluorescent Detection of Nucleic Acids in Live Cells

Iris Kao, Angelica Ochoa Fluorescence-based single-molecule imaging (SMI) methods using biomolecular sensors are often used to study the temporal and spatial activity of RNA in its physiological environment. Specifically, compelling evidence has demonstrated that RNA molecules may be as significant as protein and DNA in biological regulation and therefore play a critical role in genetic disorders and diseases such as cystic fibrosis or cancer. In this project, we designed a universal biomolecular sensor based on Spinach, an aptamer that binds and switches on the fluorescence of a small molecule fluorophore, to fluorescently and sequence-specifically detect endogenous nucleic acids in live cells. The fluorescence response of the split Spinach construct to target mRNA was measured in vivo using FACS flow cytometry and in vitro using fluorescence spectroscopy. Our data show increased fluorescence of the split Spinach-fluorophore complex in the presence of target mRNA versus in the presence of shuffled target mRNA, Spinach-fluorophore complex alone, and buffer alone. Further work is needed to increase the sensitivity of our split Spinach-fluorophore complex to improve signal-to-background ratio.

AlternaGel: The Alternative Ultrasound Gel for Resource-Limited Settings

Suvomita Ghosh, Sydney Moy

In developing regions of sub-Saharan Africa, portable ultrasound has become a common diagnostic tool used to monitor both mother and child during the prenatal period. Despite its accessibility, this technology is rendered useless without a proper coupling gel. Due to a lack of local manufacturing, the high costs of transportation, and difficulties with storage, there is a shortage of ultrasound gel that has led to material substitution. These substitutes, such as yogurt, shampoo, and mineral oil, have damaging effects to ultrasound transducers and limit diagnostic efficiency over time. In this project, an alternative ultrasound gel is synthesized from ingredients currently available in Kenya. To design this alternative gel, property tests have been developed for acoustic impedance, inertness, viscosity, bacteriostaticity, heat resistance, and electrical resistance. These tests have been conducted on both industry gels and potential substitute ingredients, such as cornstarch and cellulose, to select an alternative that functions comparably to current gels. Experiments have shown that a formula developed from a mixture of cornstarch and water can provide a sufficient alternative to industry gels based on its thermal, mechanical, and acoustic properties. Additional components, such as turmeric and cinnamon, have been added to stabilize the cornstarch solution for bacteriostaticity. This proposed formula can be used as an alternative ultrasound gel to provide a more readily available means of continuing prenatal care and decreasing infant mortality rates.

Cell Phone Based Phase Contrast Imaging

Ana Sofia Camacho, Michael Francis, Doug Webster Millions of people die from malaria every year, and in many cases the disease occurs in areas of the world where laboratory diagnostic tests for early detection are not easily accessible. A portable optical device could be used to image a blood smear slide and determine if the disease is present, but standard optical microscopy is insufficient to resolve malarial protozoa. Cell-phone camera based phase contrast imaging has the potential to utilize a portable optical device to acquire sufficient information for diagnosis. This project designed and tested optical configurations for a cell phone lens camera attachment system using a partitioned aperture wavefront (PAW) lens to produce phase contrast images with a cell-phone. Our macroscopic prototype of the designs yielded phase contrast images with four simultaneously acquired angles of illumination, producing a large amount of information with each image. Another configuration was devised that will compensate for the built-in infinity-corrected lens found in a typical cell phone camera. The optimized design was constructed and tested on a bench-top prototype, and phase contrast images were successfully acquired using a cell-phone camera and incoherent light. This optical system design can engender a fast, portable, and inexpensive malaria diagnostic.

Design and Development of a Fast MRI Pulse Sequence for the Quantification of Tissue Iron in vitro and in vivo

Robert Dalgarno, Soon Bin Kwon, Ashley Stein

Several hereditary diseases such as hemochromatosis cause excessive accumulation of iron in the body’s vital organs, such as the liver. This “iron overload” can cause liver failure, diabetes, and other health problems if untreated. The typical diagnosis requires an invasive needle biopsy to quantify liver iron concentration; however, studies have indicated that magnetic resonance imaging (MRI) can be used to detect iron deposits. Currently, two types of MRI pulse sequence families used in the clinical setting are Spin-echo (SE) and Gradient Echo (GE). Unfortunately, these images lack a comprehensive hepatic iron concentration (HIC) range because the sequences are not fast enough, which results in a patient biopsy anyway. This study attempts to improve HIC detection by design of a fast hybrid pulse sequence, which aims to expand detectable HIC range without increasing total scan time. Pulse sequences we consider include SE, GE, and the less common, albeit faster, pulse sequences: Gradient and Spin-echo (GraSE) and Turbo Spin-echo (TSE). The relationship between transverse relaxation rate (R2) and simulated HIC values was determined for the pulse sequences at 3 Tesla, as we manipulated MRI parameters such as number of echoes, echo spacing (ES), and inversion time (TI). Iron-agarose gel phantoms were also designed to mock healthy liver tissue to provide a means of testing these sequences. Mathcad® algorithms were applied to MRI scans to analyze and evaluate the effectiveness of aforementioned scan parameters. We have identified the pulse sequences that allow for wider range of HIC detection, as well as an iron-agarose gel composition ideal for mocking liver tissue over multiple uses. These findings may provide clinicians better tools for accurate HIC detection in the body, as well as a means of comparison to healthy liver iron levels, which may eventually be used as a reference alongside patients in the MRI machine.

Design of a Flow Chamber Compatible with Traction Force Microscopy

Bhumica Amin, Varuna Rao, and Jennifer Ryan

Endothelial cells lining blood vessels are subjected to several forces resulting from disturbances in both the extracellular matrix and blood flow. Measuring traction forces of these cells can promote a better understanding of cell signaling pathways. Because current approaches to obtain cellular traction forces are flawed in several aspects, the purpose of this project is to address these drawbacks by developing a novel technique in which cellular traction force measurements simultaneously take into account the effects of both fluid shear stress and cellular contractile forces. The approach consists of a method to incorporate a micropatterned hydrogel into a flow chamber to measure the traction forces exerted by cultured endothelial cells with microscopy techniques. Three major components outline the success of this project. The first is the insertion of a hydrogel into a parallel plate flow chamber under a vacuum seal without gel rupture or fluid leakage. Next, the presence of the gel is accounted for to accurately determine the shear stress applied to the cells. Lastly, endothelial cells are cultured and subject to shear stress resulting in cellular deformation. This flow chamber design allows cellular traction forces to be determined under a range of shear stresses and with various cell culture methods. By including flexibility in the design, measurements from further experiments can provide new insight into cell communication, improving the control and prevention of vascular disease.

Design of an Image Processing System to Improve Measurement of Cellular Traction Forces

Diana Aksyonova, Carolynn Gaut

Cellular traction forces (CTFs) are critical to basic cell processes, such as migration and signaling. These forces have been quantified using micro-contact printing techniques to pattern extracellular matrix proteins on hydrogels. As the cell contracts, the fibronectin focal adhesions that support adhered cells are displaced and thus can be monitored to visualize the effect of traction forces generated by the cell. Computer programs have been used with this approach to analyze the experimental images and calculate traction force vector fields, but they do not account for gel strain, limiting the accuracy of the results. We report a study in which this technique is improved by updating an image processing system that is now able to account for ancillary forces. We have developed an adjusted program to correct for gel strain during cellular traction force measurements. The method uses the displacements of nanospheres embedded within a hydrogel to derive a mathematical model that describes how a point force deforms the gel. The angular component and magnitude of the traction vector describe the amount and direction of gel movement due to the application of a point force. This equation is then incorporated into the existing program to remove the gel strain component from traction force data. Experimental images of contracted cells have been obtained and the existing program has been altered to include an easily modifiable correction algorithm. Preliminary development of the algorithm has introduced the major components of the gel strain equation. With this experimentally determined gel strain equation, the image processing system will more accurately determine cellular traction forces. Successful completion of this project enables researchers to quantify the effect of CTFs on individual cells in prospective studies.

BOSTON UNIVERSITY DEPARTMENT OF BIOMEDICAL ENGINEERING

28th

Annual Senior Project Conference

─ Friday, May 3, 2013 ─

SESSION IIIb

Small rivers:

Microfluidics

Development of Microfluidic Devices for Microscale Chemical Reactions

Saeed Ahmed

Pharmaceutical research has seen a decrease in the number of lead compounds available for biological screening, prompting a need to reconsider the ways in which lead molecules are generated. In the span of about 3-6 years, before reaching clinical trials, about 5,000-10,000 prospective lead compounds are tested for a hit; this approach is has proven to be time consuming, and expensive - usually with poor results. An under-utilized strategy in medicinal chemistry involves the miniaturization of chemical synthesis reactions; this presents an ideal opportunity for the utilization of microfluidic technologies where there can be the ability to screen many reactions in parallel. In this project we developed a device consisting of two essential parts, a top plate and a bottom plate each with complementary wells and channels; when these plates are placed together and slipped relative to one another, chemicals in the wells will mix and reactions can be initiated. This device was fabricated from silicon wafers using standard photolithographic and dry etching procedures and requires only a pipette to operate. In addition to this device, a photochemical microreactor was developed to expand the range of chemical reactions possible. We have incorporated this device into a photo-optic platform, a UV irradiation system allowing for light-directed chemical synthesis. These devices show the potential to enable hundreds of rapid microliter scale chemical synthesis reactions for the biological screening of small molecules. This work has demonstrated the ability to facilitate rapid and parallel chemical synthesis reactions on a microfluidic device improving on the efficiency of lead molecule generation and advancing drug discovery.

Microfluidic Chip for Thyroid Cancer Diagnosis

Lena Liu, Matthew Scott Fine needle aspiration (FNA) biopsy followed by a histological analysis of biopsied cells is the current gold standard for thyroid cancer diagnosis. However, the qualitative nature of this method simultaneously wastes hospital resources and unnecessarily subjects many patients with benign thyroid nodules to multiple procedures as many of these biopsies are classified as indeterminate. In this study, we developed a microfluidic device that is able to isolate and identify protein biomarkers from a thyroid cancer cell line that is used near the point-of-care as an additional diagnostic method. First, a selected protein biomarker is purified from a lysed mammalian cell sample by a microfluidic device analog to an ion-exchange column. Second, a modified on-chip immunoassay was developed to identify the biomarker and was optimized for protein adhesion. The results indicate that thyroid transcription factor-1 (TTF-1) can be extracted from the resin and porous polymer monolith (PPM) filled microfluidic channels. Additionally, TTF-1 was identified from the lysate sample and tested on a miniaturized immunoassay. The combination of the two novel devices represents an effective approach to disease diagnosis that will provide additional insight, expedite results, and increase diagnosis specificity for patients.

Design and Characterization of an Integrated Microfluidic System for Sample Concentration and Extraction

Rebecca LaCroix, Michelle Wong

In resource-limited areas, care for patients with human immunodeficiency virus (HIV) is often limited by lack of easy access to a quantitative viral load test. A low-cost, point-of-care diagnostic test that could quickly and efficiently detect HIV would improve testing standards and have the potential to impact patient care. When developing a test suitable for this application, sensitivity is often sacrificed to favor low cost, portability and speed. To address the issue of sensitivity while preserving low cost, we present a closed microfluidic system that will concentrate a human blood plasma sample to ensure that the HIV concentration is above the lower limit of detection of the sensing technique. Our system consists of two modules: (1) a microfluidic chip for sample concentration via evaporation and dialysis and (2) a solid phase extraction column in a syringe needle for extraction of HIV RNA following virion lysis. The system uses minimal grid power by replacing in-house components with portable versions. We have demonstrated a working prototype that concentrates plasma to a volume factor of ten and extracts HIV RNA for quantification. The low-cost, portable components of the microfluidic system are a step towards developing a more accessible HIV diagnostic platform.

Ultrasonic Filtering and Detection for Microfluidic Devices

Andrew Beckenbach, Brittany Culpepper, Anjanesh Venkatesh

The presence of circulating tumor cells (CTCs) in the bloodstream is indicative of

advanced cancer and is associated with a greater chance of lethality. Current methods

to isolate and detect CTCs in blood result in low yield and purity. Ultrasound

manipulated filtration has been studied as a solution as a more sensitive test for the

earlier detection of CTCs as well as a diagnostic of cancer detection. Our approach

utilizes ultrasonic standing waves to exert a radiation pressure that separates particles

based upon their physical size in a microfluidic channel. The channel was designed to

have three different output branches and two different input branches to increase the

capability of the design to isolate various particles. Ultrasound transducers were

designed to maximize efficiency over a range of frequencies and positioned on angled

wedges to emit ultrasound waves into the channel. A microfluidic pump was used to

continuously filter particles to yield a higher purity over time. The goal of the prototypes

involves manipulating particles into separate channels by varying the position of nodes

inside our micro-channel. The proof-of-concept demonstrates the need to optimize the

microfluidic chip for a range of different CTC cell types or microbubbles so that the

device can serve as a diagnostic for multiple cancers.

Integration of Microfluidics with Multiplexed Plasmonic Biosensors

John Barrett, Erik Frazier, Dylan Stevens

Point-of-care diagnosis requires development of rapid, accurate and effective detection of biomarkers. Between the existent methods, surface plasmon resonance (SPR) technology is considered the gold standard model for real-time and label free analysis of bio-molecular interactions. However, this sensing device is costly, has low throughput, and is difficult to integrate with other technologies. In contrast, plasmonic nanohole arrays (PNA) have emerged as an alternative SPR method and are used in our group as a label-free biosensor to detect the adsorption of proteins and viruses. In this work, we fabricate a robust and low-cost PNA sensor integrated within a microfluidic device with multiplexing capabilities. Furthermore, we optimize the surface chemistry of our sensors to detect the interaction between antibodies and antigens. Measurements were done on both conventional SPR and PNA sensors at relevant concentrations. Two different antibody-antigen systems have been studied and used to prove the sensitivity and selectivity of our device and its possible application for medical diagnosis.

Optimization of a Polyolefin Surface for the Immobilization of Biotin

Chun Hin Tang, Jeanne Tran Modern DNA amplification technologies can be used to identify bacteria and viruses, match crime scene DNA to criminal suspects, and detect hard-to-treat diseases such as cancers. PCR (polymerase chain reaction), a process that produces billions of copies of single strands of DNA segments, is the most common DNA amplification method. Since traditional PCR technologies require the use of large, bulky machines, the process is quite costly and time-consuming. Another DNA amplification method is RCA (rolling circle amplification), which produces pure, high concentrations of DNA copies, without going through the trouble of purification process. Novel technological approaches aim to condense the entire process of these methods onto a micro-sized chip; therefore, conserving materials, reducing cost, and facilitating mass-production of the chips. Another cost-reducing approach is to fabricate these chips from polymers instead of glass; polymer materials are easily replaceable, yet have smooth, clear surfaces that can be modified for the adhesion of proteins and biomaterials. Our research focuses on increasing the hydrophilicity of the surface of cyclic polyolefin (COP), a type of polymer, by modifying the COP surface via oxygen-plasma treatment and chromic acid etching. Effects in varying positioning of the chips in the plasma chamber were tested along with exposure times of oxygen-plasma and chromic acid treatment. Optimal treatment times of the COP surface were verified by a hydrophilicity test using contact angle measurements. The ultimate goal is to enhance the immobilization of biotin to the COP surface for optimal trapping of biotinylated DNA. Biotinylation was verified by fluorescent streptavidin under blue light, where a high concentration of fluorescent signals confirms the presence of a biotinylated polymer surface. Our results indicate that varying positions of the COP chips in the oxygen-plasma chamber does not have a significant effect on the hydrophilicity of the chips. Furthermore, the contact angle data show that the optimal length of treatment for both oxygen-plasma treatment and chromic acid treatment are shorter than the expected treatment time. All in all, modification of COP chip surfaces can offer a faster and cheaper method for DNA amplification for use in clinical diagnosis of disease detection.

Blood Glucose Monitoring System for Use in Developing Countries

Socrates Boutsikaris, Shannon O’Neill Diabetes is a chronic disease affecting hundreds of millions of people worldwide that is managed through frequent self-monitoring of blood glucose. In the developing world, where over 80% of diabetes deaths occur, frequent self-monitoring of blood glucose is prohibitively expensive and requires technology that is inaccessible to the average patient on a daily basis. This results in millions of patients living with the risks of unmonitored diabetes due to a lack of access to a simple daily blood test. To combat this issue, a device has been developed for blood glucose testing that can be used by multiple patients in a centralized and local setting, thus reducing costs and increasing accessibility. Additionally, a method for identifying, storing, and communicating each patient’s test results with their physician has been established. The combination of these two components represents a comprehensive system for blood glucose monitoring that has been designed to keep costs low and reproducibility high for successful implementation in a developing country. This system has been manufactured to perform blood glucose tests in a sanitary manner, including an automated internal disposal system, tested for sanitation using cell cultures, and incorporated with written software that identifies each patient and uploads his or her test results to an online database that is accessible to their doctor. This system will make the management of diabetes more affordable and accessible to patients in developing countries by providing not only frequent testing of blood glucose levels, but also by tracking that information overtime so it can be utilized by doctors to dictate future treatments.

BOSTON UNIVERSITY DEPARTMENT OF BIOMEDICAL ENGINEERING

28th

Annual Senior Project Conference

─ Friday, May 3, 2013 ─

SESSION IV

We Have the

Technology: high-tech

solutions to real

problems

Design of Noninvasive Technology for Real-time Estimation of Hyolaryngeal Kinematics for Videogame Control

Emily Bonazelli, Lynne Messina

Swallowing is a complex sensorimotor behavior that requires coordinated bilateral activation and inhibition among more than 25 muscle pairs of the mouth, pharynx, larynx, and esophagus. Swallowing problems can arise in individuals suffering from neurological disorders such as Parkinson’s disease and stroke, and can lead to malnutrition and death. To help subjects practice controlled movement of the laryngeal cartilages, a developed rehabilitation videogame utilizes surface electromyography (sEMG) sensors placed on the anterior neck as a control signal to a video game. While sEMG provides a direct way to measure the activation of the muscles of the neck, it does not precisely correlate with laryngeal kinematics. Pressure sensors were used to provide direct feedback of real-time laryngeal kinematics to serve as the new control signal for the rehabilitation video game. Six healthy subjects were recruited (3 women) between the ages of 18-30 and tested with both the pressure sensor system and the sEMG. A user survey was administered to the subjects to examine the differences in how sensors felt during play of the video game. Subjects stated that there was no significant difference in difficulty of play between systems. Most subjects felt that the pressure sensor system was more comfortable and made him/her move the larynx in a more controlled manner. For future work we plan to continue testing these systems on individuals with swallowing disorders.

Design and Testing of a New Nebulizer

Andreas Kapfhammer, Christopher Lim

Nebulizers are integral pieces of equipment in the treatment of patients with respiratory diseases such as asthma, cystic fibrosis, and chronic obstructive pulmonary disease. Nebulizers prepare medication to be inhaled through a delivery system. The optimization of such delivery systems on a patient specific manner is of high medical importance, and has yet to be achieved. Our group hypothesizes that timing the release of medication at specific phases of an inspiration can vary the penetration depth of an administered drug. The objective of this project is to design and test a novel delivery system able to synchronize drug delivery, in real time, with the subject’s specific respiration. A software program, LabVIEW, was used to control a solenoid valve, which regulates the nebulizer output by opening when it experiences a 12V DC current. A flexiVent ventilator simulated a rabbit’s 1 Hz breathing pattern by supplying air from the base unit through a shaft to a mechanical analogue simulating a rabbit’s lung resistance and compliance. When the inspiratory flow rate exceeded a predefined threshold, LabVIEW was triggered to output a voltage through an inverting op-amp circuit. This op-amp circuit amplified LabVIEW’s output signal to provide the 12V required to open the solenoid valve, therefore allowing the aerosol medication into the ventilator system. The tubing system connecting the nebulizer to the valve, the valve to the ventilator, and the ventilator to the rabbit-scale end of the ventilator shaft was designed to minimize dead space in order to diminish the amount of condensed drug-laden solution that resides in the tubes. This is to ensure that the prescribed amount of drug is delivered to the lung rather than becoming deposited in the dead space. Preliminary results from our experiments show that when drug release is timed, there is an inverse relation between the inspiration phase and penetration depth. The completed device enables future investigation into the ability of flow-sensitive drug delivery to alter drug deposition depth with various parameters ranging from subject inspiration frequency to subject weight. Once the system is able to efficiently deliver drugs by using our computer-controlled method, following further testing, it could be useful in human application in the future.

Stochastic Resonance Ankle Brace for Improving Balance

Corey Kronman, Bhavesh Patel Aging, injury, and degenerative nerve disease cause decreased somatosensory feedback to the central nervous system. This leads to diminished proprioception, or spatial awareness. Diminished ankle proprioception can result in the loss of balance, falling, and further injury. Current treatment for diminished ankle proprioception includes bracing and rehabilitation therapy. Bracing alone provides structural support during static and dynamic tasks while rehabilitation therapy can minimally augment feedback after weeks of exercise treatments. To decrease the threshold for somatosensory feedback from the ankle, and therefore improve proprioception, we applied stochastic resonance (SR) to mechanically stimulate damaged mechanoreceptors in the ankle ligaments. SR is a phenomenon in which the introduction of low-level noise to the nervous system enhances the detection of sensorimotor signals. We embedded piezoelectric actuators into a neoprene ankle brace to deliver SR stimulation to the mechanoreceptors of three ankle ligaments: the anterior talofibular ligament (ATFL), posterior talofibular ligament (PTFL) and calcaneofibular ligament (CFL). When the brace is worn, the actuators sit atop the indicated ligaments. An electrical control box, to generate the noise signal and control its amplitude, was designed with a programmed Arduino Uno microcontroller and custom printed circuit board. As part of a human study, two participants were recruited: one previously injured participant and one healthy participant. Both participants performed joint position sense (JPS) and single leg stance tests (SLST) to determine balance improvements with and without SR stimulation. Data was collected in a motion capture lab equipped with electric goniometers for the JPS tests and forces plates for the SLST. Analysis of the pilot study data is inconclusive and a larger human trial must be conducted before generalizing the effectiveness of the SR ankle brace.

Mobility Aid for the Blind

Christian Dorman, Ghassan El Kara, Ralph Sayad

Now more than ever, in increasingly crowded and fast-paced environments, technological innovation needs to be applied to the development of new and more effective mobility aid devices for the blind and visually impaired. The objective of this project is to design a mobility aid device that will significantly improve mobility by conveying spatial information through sound, using ultrasound echolocation and digital signal processing. The device consists of a pair of sunglasses equipped with ultrasonic emitters and receivers, powered by a circuit board connected to a computer. The system can be separated into three functional components: a digital processing unit, an analog circuit, and an ultrasound transducer array. The computer calculates the distance to the nearest impeding object and plays an audible sound to the user. The analog circuit acts as the intermediary between the transducers and the digital processor. Finally, the transducer array provides the optimal beamwidth for scanning the perimeter. The device conveys spatial information such as azimuth location by delaying the tones played at every ear by the respective computed Interaural Time Difference (ITD). Results from experiments in the Cochlear Mechanics Lab demonstrate that our device is able to detect the trajectory of large objects—such as a whiteboard—at up to three meters in crowded environments. Further experiments were conducted to determine the optimal sampling rate, which was 125 kHz. Our system not only provides multiple cues—ITD, distance through frequency, and amplitude shadowing—to enhance the navigation percepts of the blind, but it also provides an effective research development tool through our graphical user interface. Our interface allows the user to select a wide variety of parameters such as number of cycles presented in a pulse, excitation frequency, sampling rate, and time-frame, which grants developers flexibility in data processing and collection. While running the program, the user can simultaneously observe the pulse echoes at each microphone, the emitting pulse, the trajectory, and the ITD values in real-time. We believe that our interface can provide a strong foundation for research and advancement in the field of navigation aids and echolocation.

Making Robots Roam: Development of an Interface Between a Biologically Inspired Goal Directed Navigation Model and a Robot

Tariq Bugrara, Collin Neill

Autonomous robots are situational and their navigation requires large computational power or a previously built network in order for the robot to determine position and build a map of the environment. Biologically inspired models have been released that uses goal-directed navigation based around forward linear look-ahead probes and interactions with reward diffusion. However, the model has only been implemented virtually. The objectives of this project are to develop a code module around the methods of the virtual rodent module and to quantify the results with a tracking system. The tracking system will be developed in MATLAB and use Microsoft’s Kinect as the visual input. The system will use basic object segmentation and recognition to determine the robots position. The system is built around the principle of color contrast edge detection. The tacking system will determine the distance traveled and the time eclipsed. The robot navigation module will be developed in MATLAB and implemented to the e-puck platform. The module will mimic neural behavior by allowing the selection of new trajectories towards the goal. An algorithm was designed to simulate random exploration of the robot. Velocity values are calculated randomly and applied to the wheels of the robot. The calculated wheel velocities are recorded and sent to an algorithm designed to convert wheel velocity into position data of the robot. Position data is calculated from wheel velocity and is fed to the simulated model, which maps place cells. We then used a more sophisticated model, which mapped head direction cells, place cells, and grid cells. Calculations from the mapped cells were used to govern smarter robot navigation in subsequent trials in the given environment. After navigation the robot can access the map within its memory stored on the computer. By looking at the map the robot can determine the next trajectory by comparing look-ahead probes and determining which one causes prefrontal cortex cells to generate the largest reward signal. By implementing the use of look-ahead probes and reward diffusion the robot was able to exploit advantageous changes in the environment that allows for the robot to take shortcuts through unexplored locations.

Making Robots See: Development of a Robotic Visual Sensing Module

for Biologically Inspired Goal Directed Navigation

Matthew Kramer, Sean Manton

The use of simultaneous localization and mapping (SLAM) in the autonomous goal-

directed navigation of robots is desirable as it does not require an external reference.

However, current SLAM techniques rely on the static world assumption. The Hasselmo

Lab has developed a grid-cell interference model of how rats perform goal-directed

navigation that shows promise at functioning in a dynamic environment during computer

simulations. We report our integration of this model with real visual input supplied by a

Microsoft Kinect. The heading and speed of the Kinect is calculated by tracking the 3D

position of corresponding features between consecutive frames using a RANSAC based

algorithm. The place-cell based map generated in this fashion is much less data

intensive than many SLAM mappings as it does not need to exactly match ground truth

to function. By checking against previously extracted feature data when the path

integration estimate is within a certain distance of a place cell firing field, our SLAM

implementation was able to successfully detect loop closures in a static environment. As

the accuracy of the place-cell map is supported by successful loop-closure detections,

goal direction is easily implemented within the model. Our efforts provide static world

groundwork for the Hasselmo model upon which it may be further tested and developed

for use in dynamic real world environments.

Reconfigurable Endoscopic Capsule Minibots Using Modular Assembly

Jason Pui, Suraj Rama, Ben Szewczyk Ingestible capsule endoscopy is a less invasive method of imaging the gastrointestinal tract than traditional tube-guided endoscopes, and it improves patient comfort and reduces risk of infection. However, endoscopy capsules have limited capabilities as a result of short battery life, a non-repositionable camera, and lack of motion control. To overcome those limitations, we have designed and prototyped a 4x model that consists of four wirelessly powered capsules with the ability to attach to one another once swallowed and assemble into a larger more complex robot. All design work and motion study planning was carried out in Solidworks before prototypes were built. The capsules have been designed to move with controlled locomotion using a continuous rotational servo that propels the capsule forward or backward and an angular servo used to bend the capsule for steering. A linear servo in the capsule is used to reposition a magnet which is attracted to a magnet on the docking station, to which several capsules connect. The capsules demonstrated the ability to be controlled and steered to the docking station. Docking specificity was observed and the final assembly with all capsules attached to the docking station exhibited controlled locomotion and was capable of being steered around obstacles. The capsules were also capable of undocking, which is important for exiting the human body. These results demonstrate that it is possible to create a larger more complex robotic system from smaller robots that are ingestible. Patients will benefit from our platform of reconfigurable robots, as future developments have the potential to lead to less invasive and safer methods of collecting biopsies, performing surgery, and diagnosing disease.

BOSTON UNIVERSITY DEPARTMENT OF BIOMEDICAL ENGINEERING

28th

Annual Senior Project Conference

─ Friday, May 3, 2013 ─

Student

Resumes

SAEED B. AHMED 73 Verndale St, Brookline, MA 02446 ∙ (619) 201-9124 ∙ saeed2@bu.edu

EDUCATION Boston University College of Engineering Boston, MA Bachelors of Science in Biomedical Engineering Expected: May 2013

Recipient of Undergraduate Research Opportunities Program Funding Award

Relevant Coursework: Biomed Instrumentation, Nanotechnology, Thermodynamics, Organic Chemistry, Eng Computation,

Signals & Systems, Control Systems, Fluid Mechanics, Biomedical Measurements, Electronics, Transport in Living Systems

EXPERIENCE Beeler Research Group, Boston University Department of Chemistry Boston, MA

Research Assistant August 2012 – Present

Developing novel microfluidic devices to run many reactions in parallel for the purpose of optimizing lead molecule

generation in drug discovery for Parkinson’s disease and epigenetic targets for cancer.

Developing a photochemical microreactor to expand the range of chemical synthesis reactions possible on the microscale.

Utilizing SolidWorks to model devices and design photomasks for the microfabrication of microfluidic chips.

Creating precise microscale features on silicon substrates using deep reactive-ion etching via the Bosch process.

Chen Lab, Boston University Department of Chemistry Boston, MA

Research Assistant August 2011 – May 2012

Designing and developing an on-board self-regulating chemical pump as a power source for microfluidic devices.

Collaborated with a faculty professor to write a research proposal that received funding from Boston University.

Performed controlled tests determining the binding strength of PDMS on various materials in order to optimize its adhesive

properties to different materials.

Reasoned Care Education Foundation Inc. San Diego, CA

Business Analyst Intern July 2012 – August 2012

Attended meetings with the executive management team of two start up companies in the pharmaceutical and medical

device industries to provide marketing, finance, and engineering consulting services.

Delivered white papers in market research and financial analysis to each company’s business plan with the objective of

venture capital funding.

Profiled the top competitors in their respective markets and provided detailed product descriptions to the management team.

Klapperich Lab, Boston University Department of Biomedical Engineering Boston, MA

Research Assistant January 2011 – May 2011

Optimized microfluidic chip production protocols by fabricating and testing microfluidic chips for low-cost point-of-care

molecular diagnostic applications.

Manufactured microfluidic chips by hot embossing cyclic polyolefin onto a silicon master mold and by a thin film layered

approach utilizing CAD to create microfluidic channel designs.

Prepared photosensitive solutions consisting of Silicon nanoparticles for the solid phase extraction of nucleic acids.

Tested the efficiency of the microfluidic chips quantitatively using a continuous flow syringe pump.

Engineers Without Borders at Boston University Boston, MA

Technical Lead and Project Manager September 2010 – May 2012

Led the design team of about 20 engineers to research and prototype a cell signal amplification device to improve an

already existing infant mortality diagnostic communication system between clinics in rural Zambia and the capital, Lusaka.

Designing, prototyping, and testing various signal amplification systems that are to be implemented in the rural clinics.

PROJECTS Prepared a full project plan for the development of a bio-prosthetic heart valve adhering to patent law and FDA regulations.

Designed electromyography signal processing algorithms to study the effects of caffeine on muscle tremors.

Created an electrical circuit as well as a MATLAB program to model saccadic eye movements.

Analyzed and identified an unknown gene sequence using modern molecular cloning and DNA amplification techniques.

SKILLS Laboratory: Photolithography, Photomask Fabrication, Dry Etching, Soft Lithography, Plasma Etching, Hot Embossing

Software: LabVIEW, SolidWorks, MATLAB, LaTex, SigmaPlot, PSpice (CAD), MS Office

Electronics: Oscilloscope, Function Generators, A to D Converters, Basic Analog and Digital Design, Analog Amplifiers

Ulises Alvarez Box 9282, 33 Harry Agganis Way, Boston MA 02215 985.630.4166 ualvarez@bu.edu

OBJECTIVE Seeking an employment opportunity in the Engineering / Biomedical fields EDUCATION Boston University College of Engineering; Boston, MA Bachelor of Science in Biomedical Engineering May 2013 Relevant Coursework: Signals and Systems, Electric Circuit Theory, Systems Physiology, Molecular Cell Bio, Eng. Mechanics, Business Technology Innovation, Control Systems Bio, Fundamental Fluid Mechanics, Fundamentals in Optical Microscopy, Organic Chemistry, Introduction to Neuro-Engineering, DNA Structure EXPERIENCE Androgen Clinical Research Unit, BU Medical Center; Boston, MA Research Assistant January 2011- September 2012

• Created a database using Microsoft Access to organize and correlate data collected from research trials • Interviewed potential candidates for androgen clinical trials • Screened patients for eligibility in the Testosterone and Pain study (TAP/TOP)

Focus Research, Inc; Mandeville, LA Project Analyst May 2010-January 2011

• Organized data collected through market research for companies such as Entergy, Shell, and Copelands • Analyzed data using excel and created presentations with PowerPoint for clients

The Shutter People; Mandeville, LA Worker May 2009-September 2009

• Managed warehouse operations for a construction company PROJECTS EOG Controlled Mouse

• Designed a hands free interface to connect the subject to a computer screen. • Developed an eye-controlled mouse for computers with real-time input. • Analyzed electrooculogram (EOG) readings taken from a subject to optimize accuracy. • Utilized Matlab to change electrical input of EOG to pixel coordinates for mouse control.

FDA Medical Device Project • Disassembled a glucose pump in order to model in Solidworks. Used model to analyze weaknesses in

design. Researched relevant FDA regulations pertaining to glucose meters and presented findings to class

Business of Engineering and Technology Project • Developed a mock mobile app company named Grub Guide that accounted for user input • Researched the needs of the customer to better the prototype, and determined the viability of the product

on today’s market Senior Project- In Vitro Mucosal Membrane Culture Model For Drug Delivery

• Cultured primary nasal epithelial cells obtained from patients with nasal polyposis • Dosed cells with various medications to study their effectiveness • Quantified results using spectrophotometry and optical microscopy

SKILLS Computer: MATLAB, LabScribe 2, LabVIEW, Solidworks, Excel, Word, Access, Visual Basic Laboratory: Gel electrophoresis, cell culture, iWorx, PCR, Electrooculogram (EOG), Electrocardiogram (ECG), Ultrasound Imaging, Spirometry, Microscopy, Image Analysis Languages: Fluent in Spanish ACTIVITIES Participated on the FIRST Robotics Competition Spring 2010-Spring 2011 Member of the Biomedical Engineering Society (BMES) at BU Spring 2011-Present

Bhumica Amin 879 Beacon St, Apt 43 Boston, MA 02215 Phone: 603-717-2704 E-Mail: bamin17@gmail.com Education Boston University College of Engineering, Boston, MA 8/09-Present

Bachelor of Science, Biomedical Engineering, May 2013 Nanotechnology concentration with a Minor in Chemistry

Research Experience Research Assistant in Dr. Michael Smith’s lab at Boston University in Boston, MA 9/12-Present Research on measuring traction forces of endothelial cells subjected to fluid drag forces

Working on a technique to measure the traction forces exerted by the endothelial when subjected to fluid drag forces. This research involved literature research, design, and running experiments.

Research Assistant in Dr. Joyce Wong’s lab at Boston University in Boston, MA 3/10-Present Research on nanoparticles and microbubbles for drug delivery

Research on nano-particles for a few months. Currently working on producing stable polymerizable microbubble for drug delivery and ultrasound contrast agents. This research involves literature research, making lipid bubbles and collecting data.

Research Assistant in Dr. Li’s Lab at Forsyth Institute in Boston, MA 10/09-1/10 Research on Osteogenic Cells

Performing gene regulation research on osteogenic cells, ordered lab supplies, edited papers, and worked with mice. Advanced Studies Program at St. Paul’s School in Concord, NH 6/08-7/08 Research on the Gap C Gene in a Snap Dragon Plant

Studied molecular biology and sequenced the Gap C gene in a Snap Dragon plant. The project involved performing assays, gel electrophoresis, and chromatography.

Publications Sequencing on GapC gene at St. Paul’s School, Concord, MA

Amin, B., Beaudry, K., Roy, A., Savard, L., Sheehan, C., Cunningham, L., et al. (2009, February 2). Antirrhinum majus glyceraldehyde-3-phosphate dehydrogenase gene, parti - Nucleotide - NCBI. National Center for Biotechnology Information. <http://www.ncbi.nlm.nih.gov/nuccore/FJ374124.1>

Tunable Diacetylene Polymerized Shell Microbubbles as Ultrasound Contrast Agents Park, Y., Luce, A. C., Whitaker, R. D., Amin, B., Cabodi, M., Nap, R., Szelifer. I., Cleveland, R. O., Nagy, J.O., Wong, J.Y.

(2012). Langmuir, 28(8), 3766-3772. Conferences C1. Yoonjee Park, Adam C. Luce, Ragnhild D. Whitaker, Bhumica Amin, Mario Cabodi, Rikkert Nap, Igal Szelifer, Robin O.

Cleveland, Jon O. Nagy, and Joyce Y. Wong, ―Tunable Diacetylene Polymerized Shell Microbubbles as Ultrasound Contrast Agentsǁ‖, BMES Annual Meeting, Hartford, CT, Oct. 2011.

C2. Yoonjee Park, Adam C. Luce, Ragnhild D. Whitaker, Bhumica Amin, Mario Cabodi, Rikkert Nap, Igal Szelifer, Robin O. Cleveland, Jon O. Nagy, and Joyce Y. Wong, ―Tunable Diacetylene Polymerized Shell Microbubbles as Ultrasound Contrast Agentsǁ‖, KSEA-NE, Boston, MA, Feb. 2012.

Research Awards/Programs ProStars 6/10-8/10 Received funding to do research in Joyce Wong’s Lab at Boston University

Tunable Diacetylene Polymerized Shell Microbubbles Project Boston University UROP 6/11-8/11 Received funding to do research in Joyce Wong’s Lab at Boston University

Tunable Diacetylene Polymerized Shell Microbubbles Project Activities Boston University Society of Asian Scientists and Engineers in Boston, MA 4/11-Present

President; Responsibilities: Put together workshops/panels for members and work with MIT to co-host the SASE Northeastern Regional Conference

Boston University College of Engineering Dean’s Host in Boston, MA 2011-Present Volunteer; Responsibilities: Helped with tours, helping out with open house, helping out with college events, and helping out at graduation.

Skills Languages: Gujarati, Hindi, Urdu, and Spanish Computer: MATLAB, Sigma Plot, ImageJ, LabView, MathCad, Python, and Microsoft Office Application. Laboratory: Performing assays, gel electrophoresis, column chromatography, planar chromatography, microfluidic flow focusing,

traction force microscopy, and cell culture.

Diana Aksyonova

72 Stacey Circle, Windham, NH 03087 dianaaks@bu.edu (603)233-1761

OBJECTIVE To be funded for current research project

EDUCATION Boston University College of Engineering, Boston, MA

Bachelor of Science, May, 2013

Biomedical Engineering Major, Nanotechnology Concentration

Cumulative GPA: 3.27

Technical University of Dresden, Dresden, Germany

Semester-long Study Abroad Program, Spring, 2011

Relevant Coursework:

Mechanics, Molecular Cell Biology, Electric Circuit Theory, Systems

Physiology, Business of Technology Innovation, Signals and Systems, Control

Systems, Digital Signal Processing, Fundamentals of Nanomaterials and

Nanotechnology,

EXPERIENCE Senior Design Research Fall 2012 – Present

Matrix Mechanotransduction Laboratory

- Currently designing an image processing system to improve measurements

of cellular traction forces.

Business Analyst Inter Summer 2012

Accenture Boston

- Interned as a Business Analyst in Systems Integration in the Financial Services

operating group.

-Developed various documents including staffing plans and responsibility

matrices

Research Position Fall 2011 – Present

The Center for Computational Neuroscience and Neural Technology (CompNet)

- Alpha Project, programming using MATLAB, leading subject examinations,

processing EEG data.

SKILLS MATLAB, SigmaPlot, EEGLAB (MATLAB Toolbox); Fluent in Russian

ACTIVITIES Society of Women Engineers, Representative, member since Fall 2010

Biomedical Engineering Society (BMEs), member since Fall 2009

HOME ADDRESS 83 Meadowdale Lane

West Seneca, New York 14224

JOHN BARRETT jcb13@bu.edu

(716) – 517 – 1462

CURRENT ADDRESS 15 Gibbs Street, Apt #3

Brookline, Massachusetts 02445

OBJECTIVE Biomedical engineer pursuing a laboratory position with opportunity to participate in ground-breaking synthetic biology research. Eager to use laboratory technique knowledge and work with a team of goal-oriented scientists to successfully engineer organisms to address today’s fundamental world challenges.

EDUCATION Boston University, College of Engineering Bachelor of Science in Biomedical Engineering, Concentration: Nanotechnolgoy

• GPA: 3.46 Technische Universität Dresden Engineering Study Abroad Program

Boston, MA

May 2013

Dresden, Germany Spring 2011

Relevant Coursework: Computer Programming, Systems Physiology, Molecular Cell Biology, DNA Structure and Function, Differential Equations, Probability & Statistics, Electric Circuit Theory, Signals and Systems, Nanomaterials and Nanotechnology, Control Systems, Computational Biology, Molecular Bioengineering, Next Generation Sequencing, DNA Nanotechnology

WORK EXPERIENCE

Integrated Nanophotonics & Biosensing Systems Lab, Research Assistant June 2012 - Present

• Optimized surface chemistry of a gold plasmonic naonohole array chip to detect VSV virus Boston, MA

• Tested the binding and blocking properties of Protein AG, Mouse IgG, goat serum and others in order to build a favorable antigen capture chemistry on gold Plasmonic Nanohole Arrays

• Learned the Surface Plasmon Resonance theory and tested binding hypotheses experimentally on this machine

• Performed weekly presentations to Principal Investigator and NIH board; discussed future of this technology and the next steps which needed to be taken

• Recipient of Summer Undergraduate Research Fellowship award among other fundingParticle Technology Laboratory, Research Assistant Fall 2009

• Performed research for improvement of inhalation drug delivery system Boston, MA

• Built a vacuum chamber device for drying and coating particles with carbon dioxide as part of a team

SKILLS Computer: MATLAB, Python, Microsoft Office, Solidworks, ImageJ, CLOTHO, SigmaPlot, CadNano, OscilloscpoeLaboratory: Pipetting, PCR, Gel Electrophoresis, PDMS, Colony Isolation, Spectrometer, Cell Culture, Ultrasound Equipment, Spirometry, Surface Plasmon Resonance Machine Certified (SPR), NMR

PROJECTS

Senior Design Project: Integration of Microfluidics with Multiplexed Plasmonic Biosensors

• Thoroughly researched relevant articles related to plasmonic biosensing and microfluidics

• Optimized surface chemistry of a gold plasmonic nanohole array chip to detect Fibrinogen and other antigens

• Drafted detailed dimensional designs of a microfluidic chamber, created computer drawings on AutoCAD

• Created a working microfluidic chamber using the Graphtec Cutter Plotter

• Performed flow tests and binding analysis on chips in the chamber to look for areas of improvement

• Presented final project at BU Biomedical Engineering Senior Design Conference Biomedical Measurements Laboratory: Effect of Caffeine on Muscle Tremor • Developed research technique to determine effect of caffeine on human muscle tremor

• Made educated redesigns to our original procedure aimed at obtaining more meaningful data

• Performed statistical and Fourier analysis on our data using MATLAB to best present our findings Business of Engineering and Technology: Business Plan Development and Analysis • Developed a company based on the idea of a Micro-fluidic IV Patch which would provide a safer and cleaner

alternative to the central IV

• Researched and understood the needs of the customer in order to efficiently develop a product they desired. Obtained complete knowledge of the market we would be working in.

• As an Engineer, gained knowledge of and appreciated the monetary constraints on a company and the need to develop products in least costly way while still retaining a strong product

HONORS AND ACTIVITIES Biomedical Engineering Society (BMES) at BU, member since 2009 Alpha Eta Mu Beta Biomedical Engineering Honor Society Member BU College of Engineering Deans List BU Off Campus Council, Senior Representative, member since 2011 BU Engineering Dean’s Host, since 2009 BU Ultimate Frisbee Team, member since 2009

Andrew Scott Beckenbach 20 Highgate St, Boston, MA 02134

(603) 733-6622 ■ abeckenbach@gmail.com

EDUCATION

Boston University College of Engineering Boston, MA

Bachelor of Science in Biomedical Engineering May 2013

Relevant Coursework

Visual Processing, Control Systems, Signals/Systems, Cell Biology/Biotechnology

Physiology, Electric Circuit Theory, Fluids, Probability/Statistics, Thermodynamics

Chemistry, Physics, Differential Equations, Mechanics

PROJECT EXPERIENCE

MATLAB Engineering Projects, Boston University 2009

Designed a script to model a body’s response to drug intake using

given data, a script to sample data output from a model wind turbine,

analyzed the data with statistical analysis, and visually presented the data.

Signals and Systems Voice Recognition Project 2011

Worked on a team of four to design and optimize a voice-recognition

program in MATLAB with a GUI that records a user's voice sample, displays

data in time and frequency domain, and consistently determines the correct voice.

Biomedical Engineering Senior Design Project 2012-13

Collaborated on a team of three to design, assemble, and test a microfluidic chip

that uses ultrasonic standing waves to detect and filter circulating tumor cells in a

blood sample with a high sensitivity and purity.

SKILLS

Laboratory

Oscilloscope, electrophoresis, spectrometry, cell culture, PCR, ECG, EOG, EMG

Computer Applications

MATLAB, SigmaPlot, AutoCAD, Java, LabVIEW, Pymol, MSOffice, PI Processbook

WORK EXPERIENCE

Automation Process Control Intern, OPK Biotech Summer 2012

Managed misc. databases and updated OIS graphics.

Worked on DCS wiring and testing plant floor sensors.

Assisted with documentation and labeling for control valves.

Assistant Innkeeper, Kancamagus Swift River Inn, Conway, NH Summer 2006-11

OTHER TITLES

Lambda Chi Alpha – President, Boston University 2010-2011

Lambda Chi Alpha – Secretary, Boston University 2009-2010

Inter-Fraternity Council – Secretary, Boston University 2009-2010

Boy Scouts: Eagle Scout Rank 2001-2008

Emily A. Bonazelli Box 8059 10 Buick Street, Boston, MA 02215 860.466.9511

OBJECTIVE

An entry-level Engineering position with an emphasis on the research and development of Medical Devices

EDUCATION

Boston University College of Engineering, Boston, MA

Bachelor of Science, Biomedical Engineering, May 2013

Mechanical Minor

GPA: 3.44/4.0 Dean’s List Recipient: Fall 2009, Spring 2010, Spring 2011, Spring 2012

Technical University of Dresden, Dresden, Germany

Semester Abroad, Spring 2011

Relevant Coursework: Signals and Systems in Biomedical Engineering, Control Theory in Biomedical Engineering,

Continuum Mechanics, Product Design, Introduction to Material Science, Biomedical Measurements Lab, Electric Circuit

Theory, Molecular Cell Biology, Systems Physiology, Systems Diseases

PROJECTS

Senior Project: Design of Noninvasive Technology for Real-time Estimation of Hyolaryngeal Kinematics for Videogame

Control

Design new technology to determine the position of the larynx to act as a control for a rehabilitation videogame

Recode already existing rehabilitation videogame to correspond with new technology

Run pilot testing with new technology

Electrical Stethoscope: Convert heart sounds into electrical signals, Fall 2011

A low-pass filter was created using a corner frequency of 2 kHz and a gain of 100 and a microphone and was

tested on a subject and once the signal was processed at a sampling rate of 100,000 Hz, the heart sounds were

transformed into electrical signals

Electrical stethoscope was tested on both female and male subjects, before and after the exercised

EXPERIENCE

Validation Intern May 2012-August 2012

Draeger Medical, Inc. Andover, MA

Designed functional tests for patient monitoring systems based on necessary requirements

Preformed tests and created Excel spreadsheets to display results

Submitted failed test results for specific requirements to software developers

Research Assistant January 2012- May 2012

Stepp Lab Boston, MA

Use signal processing program Praat to analyze the speech patterns of Parkinson patients in order to find solutions

for sensorimotor rehabilitation

Work Study Fall 2010-Present

BU College of Engineering Development and Alumni Relations Boston, MA

Gather information on prospects such as current work place or current mailing address

Host College of Engineering Distinguished Alumni Awards during Alumni Weekend and other alumni events

HONORS AND ACTIVITIES

Alpha Eta Mu Beta National Biomedical Honor Society, member since Fall 2012

Women’s Club Ultimate Frisbee Team at BU, member since 2009, Treasurer since Fall 2012

Society of Women Engineer (SWE) at BU, member since 2009, Class Representative, Outreach Coordinator

College of Engineering Dean’s Host, member since 2009

Environmental Student Organization at BU, member since 2009

Students against Genocide at BU, member since 2009, Treasurer since Fall 2012

Socrates L. Boutsikaris

76 Egmont Street Apt. 4 Brookline, MA 02446

(240) 620-5737 socrates.boutsikaris@gmail.com

EDUCATION

Boston University College of Engineering Boston, MA

Candidate for Bachelor of Science, Biomedical Engineering May 2013

Related Coursework:

Invention: Technology Protection & Commercialization, Device & Diagnostics Design, Product Design & Innovation, Business

Technology Innovation, Engineering Economy, Transport Phenomena In Biological Systems, Control Systems In BME, Signals &

Systems In BME, Solid Biomechanics, Thermodynamics, Biomedical Measurements I & II, Systems Physiology, Electric Circuit

Theory, Molecular Cell Biology, Engineering Mechanics, MATLAB

WORK EXPERIENCE

Food & Drug Administration Summer 2012

Engineering Technician, Medical Device Fellowship Program (MDFP) Silver Spring, MD

• Active member of a team of twenty-five biomedical engineers and nurses who worked in the postmarket surveillance office

within the Center for Devices and Radiological Health.

• Analyzed MedSun (Medical Product Safety Network) reports of adverse events pertaining to complex electric and

mechanical medical devices, including infusion pumps and enteral feeding systems.

• Investigated cause of adverse events through extensive research on device design, clinical event and postmarket testing.

Utilized device schematics, FDA documents & databases, as well as communication with hospitals, manufacturers, and

subject matter experts to draw conclusions.

• Explored potential trends in device failure to generate signals for compliance and regulatory actions.

• Proposed the design of a centralized database of hospital medical device maintenance logs to be utilized by MedSun analysts

to extract potential signals for recalls.

• Presented summer projects to the CDRH senior staff, including Center Director and Deputy Director.

• Received United States Government Security Clearance.

Food & Drug Administration Summers 2010, 2011

Biomedical Engineering Intern, contracted through Social & Scientific Systems Silver Spring, MD

• Analyzed MedSun reports regarding a variety of product areas such as ventilators, implantable defibrillators, electrosurgical

units and catheters.

• Assisted in the coordination of a new and more secure communication medium between the FDA and medical device

manufacturers.

• Created several device problem summary tables that summarize MedSun report information for device problems and

published them on the FDA MedSun website.

PROJECTS

Senior Project: “Blood Glucose Monitoring System for Use in Developing Countries” Fall 2012—Present

• Worked on a two-person team at MIT lab to design a multi-patient glucometer with limited materials and low cost for use in

the developing world.

• Utilized Arduino-controlled electrical and mechanical parts to develop a prototype containing patient ID, test strip dispenser,

disposal, and sanitation systems.

• Developed website and mobile application that uploads patient ID and measurement data for clinical outreach.

• Presented senior project at the Global Health Technologies Design Competition at Rice University and at the Senior Design

Project conference at Boston University.

Additional Projects:

• Designed a method by which a subject can accurately move a computer mouse cursor with their eyes in real time.

• Drafted a patent for a collapsible travel tray for lightweight collapsible strollers and presented the invention, prior art search,

claims, and business plan to the class.

• Acted as a Medtronic R&D team with two students to apply product design and development knowledge to manufacture the

MiniMed Paradigm Insulin Pump. Followed FDA and international regulations, including quality control and FMEA

analysis, to create a proposal for manufacturing and future marketing.

• Designed a novel endoscopic device that can remove suspicious polyps from the colon for further histological analysis.

SKILLS

Computer: MATLAB, LabView, SigmaPlot, ImageJ, Arduino Microcontroller, Google SketchUp, Microsoft Office

TARIQ BUGRARA 826 Beacon Street Boston, MA 02215 • tbugrara@bu.edu • (774) 279-7369

OBJECTIVE A full-time job as a software engineer in the biomedical industry

EDUCATION Boston University, College of Engineering Boston, MA Candidate for Bachelor of Science, Biomedical Engineering May 2013 Related Courses Signals and Systems Fluid Mechanics Cardiovascular/Respiratory Systems  Control Systems Introduction to Probability Computational Methods in BME Algorithms and Data Structures Introduction to Linear Algebra Introduction to Neuroscience Computer Skills

Programming: Java, C#, C++, MATLAB, Adobe Flex, XML, JavaScript, Ant Software: Eclipse, Microsoft Visual Studio Express, Xcode 4, Servlets, Tomcat, Apache Web Server, Netbeans IDE 7,

Photoshop and Illustrator (basic) O/S: Windows XP/Vista/7, OSX 10.6/7/8, Linux

Projects • In a team of 4, designed and implemented software program for a medical device to calculate a signal's angle relative to

the device as well as successfully removing most noise using Fourier transforms in MATLAB. • Modeled gene-protein network with complex relationships to determine final state concentrations in Java

WORK EXPERIENCE Wiseor Inc. Stanford, CA August 2012 - Present Software Engineer

• Designed the SQL schema for the company's hospital data analytics product. • Developed module in Java that takes an arbitrary customer CSV data extract and automatically maps it into the SQL schema.

• Developed module in Java that generates and emails personalized performance reports to clinicians and hospital managers as embedded HTML and PDF attachments.

Boston University Boston, MA September 2012 - Present Software Engineer

• Working in a team of 2 to implement a goal-directed navigation model based on neural cells in rats to a small robot in MATLAB. Also developing tracking system to monitor robot movement using Microsoft Kinect.

• Wrote proposal and paper outlining the research and work involved in this NASA funded project. Designing Business Inc., Framingham, MA Summer 2012 Software Engineer

• Designed and implemented tool in neonatal care mobile application on iPad tablet to visually map areas of a neonatal body with different procedures including text notes, pictures, and audio recordings (Flex). The tool is used by an ICU team at Boston Children’s Hospital to document clinical procedures on their transport vehicles.

• Designed and implemented blood gas measurement tool to graphically depict gas concentrations and predict possible diagnosis to aid neonatal clinicians caring for premature babies in the first 6 hours of birth.

Boston University IT Help Center, Boston, MA May 2010 – May 2012 IT Services Consultant

• Worked face to face with students and faculty to solve problems on their machines (OSX 10.5/6/7 and Windows XP/Vista/7). • Trained new consultants the protocols relevant to the position while troubleshooting client issues.

Designing Business Inc., Framingham, MA Summer 2011 Software Engineer

• Worked as a member of a team that developed a mobile application supporting nurses in neonatal care units to provide structured and effective doctor approved workflow when caring for newborns.

• Integrated frontend of mobile application (Flex) with backend server (Java). InviCRO, Boston, MA Summer 2009 Software Engineer

• Designed and created a software tool to efficiently process raw image data from CT scans into a video file using Magick++, the C++ API for ImageMagick.

• Worked with the company architect to fine-tune image processing algorithms to use less memory.

Ana Sofia Camacho Box 9549, 33 Harry Agganis Way, Boston, MA 02215 915-760-9381 acamacho@bu.edu

OBJECTIVE Extremely motivated engineer searching for an entry-level position with an emphasis on consulting and management opportunities. Qualifications: Strong presentation, analytical, and intrapersonal/communication proficiency EDUCATION Boston University, College of Engineering, Boston, MA Candidate for Bachelor of Science in Biomedical Engineering, May 2013

Relevant Coursework: Molecular Cell Biology, Stem Cells and Cloning, Engineering Mechanics, Tissue Engineering and Drug Delivery, Engineering Computation, Signals and Systems, Electric Circuit Theory

PROJECTS Senior Design Project: “Cell-Phone-Based Phase Contrast Imaging” Fall 2012-Present

Utilized a novel technique called partitioned aperture wavefront imaging (PAW) technology to miniaturize a microscope design.

Adapted the design as a cell phone camera attachment with the ability to work with sunlight to produce information-rich images for portable blood smear analysis.

Boston University School of Management Product Design Consultant Fall 2012, Spring 2012

Design and cost analysis consulting for product design groups to conclude feasibility of product. Business Innovation Project Spring 2012

CEO of a company producing an automated pill dispensing appliance designed for people with high medication consumption aiming to alleviate the need for the user to remember the time and quantity of the dosage comsumption.

Currently investigating patent claim for product; Culminated in a formal business proposal and presentation for Philips Healthcare.

EXPERIENCE Math Teacher, Loretto Academy Mexico; El Paso, TX Summers of 2009- 2011, 2008-2009

Selected by Loretto Academy to teach 15 incoming students ranging from ages 6 – 18 from Mexico who were struggling in school. Taught summer school for Middle School Math and High School English, Science, and Math in English and Spanish and increased their grades by 30%.

Staff Assistant, Engineering IT Help Center Boston, MA Fall 2009

Supported engineering faculty by troubleshooting engineering computer software such as: MATLAB, Java, Linux, and antivirus software.

LEADERSHIP Society of Hispanic Professional Engineers (SHPE) Region 4 Vice-Regional Student Representative for Boston (2011-Present) BU Chapter President (2012-Present), Vice-President (2011-2012), Secretary (2010-2011) Boston RLDC Student Co-Chair (2012-Present) Dean’s Host at College of Engineering at Boston University, Registration Captain (2009 – Present) First Year Student Outreach Project (FYSOP), Selected Staff Leader (2009-2012) AWARDS Leadership Certification by Johnson & Johnson at the National Institute of Leadership Advancement (NILA) 1st Place Case Study - National Institute of Leadership Advancement (NILA) 1st Place Case Study - Eastern Technical Leadership Conference (ETLC) SKILLS Software: MATLAB, Visual Basic, ImageJ, WinTruss, SigmaPlot, MathCad Languages: Fluent in Spanish and conversational French (4 years) Trained Mezzo-Soprano Opera Singer and Pianist (8 years)

Patrick W. Carney610-906-4228 (m) • pwcarney@bu.edu • 2 Chelmsford Court, Downingtown, PA 19335

EDUCATIONBoston University College of Engineering, Boston, MABachelor of Science, Biomedical Engineering, May 2013Cumulative GPA: 3.54/4.0

Relevant Coursework Control Systems, Signals & Systems, Logic Design, Software Engineering, Medical Imaging, Biotransport, Biomedical Instrumentation, Molecular Cell Biology, Nano in Living Systems, Thermodynamics, Human Physiology, Solid Biomechanics, Electric Circuit Theory, Engineering Comp., Organic Chemistry, Engineering Mechanics, Business of Tech Innovation, Prod Design and Innovation

WORK EXPERIENCEJohnson & Johnson, Malvern, PA Validation Intern: Summer 2011 & Summer 2012

• Assessed newly installed freezers and refrigerators by performing Installation and Operational Qualification evaluations.

• Ran water sample tests, swab tests temperature mappings, and validation assessments on factory equipment producing the drug Remicade.

• Assisted in moving the Validation department from a paper filing system to a digital system in SAP.

• Supported Validation Engineers in team environment during field execution of protocols by setting thermocouple readings and taking swab tests.

PROJECTSSenior Project: Creation of a cost-effective, non-invasive ventilation machine for use in treating childhood pneumonia in developing countries. Business of Technology Innovation: participated in a team that gave multiple presentations and wrote business plans as if we were starting a company that made special test-taking pencils.

TECHNICAL SKILLSMATLAB, C++, Technical Writing, Familiarity with Linux, Familiarity with GMP Environment, High Proficiency with Microsoft Office Suite, Water Quality Testing, IR Spectroscopy, Gram Staining, Thin Layer Chromatography, Distillation, Gas Chromatography Analysis

AWARDS AND SCHOLARSHIPSAdmission to Tau Beta Pi – Engineering Honor SocietyAdmission to Alpha Eta Mu Beta – Biomedical Engineering Honor SocietyEngineering Scholar AwardDean’s List - Fall 2009, Spring 2010, Fall 2010, Spring 2011, Spring 2012

ACTIVITIES AND ORGANIZATIONSStudent Adviser for College of Engineering – taught weekly class to group of incoming freshmen and mentored them, easing their transition into the College of EngineeringRecording Secretary for Tau Beta Pi – Engineering Honor SocietyEngineering Tutor – open hours tutoring in any engineering subject (paid position)Residence Hall Assoc. Floor Rep – represented Engineering floor of Shelton Hall residenceEngineering Dean’s Host - Conducted engineering department tours for prospective students and parents and assisted College of Engineering setting up and running events

Benjamin P. Cohen 15 Gibbs St Apt 3 • Brookline, MA 02446 • (518) 487-9133 • bpcohen@bu.edu

OBJECTIVE A full time position within the field of biomedical engineering involving research and/or development of healthcare

technology.

EDUCATION Boston University, College of Engineering, Boston, MA

Bachelor of Science in Biomedical Engineering – Anticipated date of completion 05/2013

GPA: 3.93/4.00, Dean’s List: 7 Semesters (Fall 2009 – Fall 2012)

Tel Aviv University, Tel Aviv, Israel

Boston University Engineering Study Abroad Program, Spring 2011

Relevant Coursework Tissue Engineering, Biomaterials, Thermodynamics, Fluid Biomechanics, Solid Biomechanics, Biotransport, Control

Systems, Signals and Systems, Systems Physiology, Electric Circuit Theory, Cell Biology, Software Engineering

SKILLS Laboratory: Electrospinning, confocal microscopy, contact angle testing, electrocardiogram, electrooculogram,

biological signal sampling, optical microscopy, tensile testing, ultrasound.

Computer: C++, Java, MATLAB, COMSOL, Mathematica, SigmaPlot, LabView, Microsoft Word and Excel

Language: Conversant in Hebrew

WORK EXPERIENCE

Lab Technician June 2012 – August 2012

Tien Lab, College of Engineering, Boston University Boston, MA

Assisted in research to quantify microvascular permeability using non-constant filling rates

Validated finite element models of transport for microfluidic systems using COMSOL Multiphysics

Tested and refined optimizing code for a permeability algorithm built around a numerical integration scheme and

MATLAB

Audio/Visual Technician October 2010 – Present

School of Law, Boston University Boston, MA

Set up and maintain recording and display equipment, reproduce audio and video class recordings for student use,

and troubleshoot electronics issue

Software troubleshooting for both Mac and PCs

PROJECTS

Research and Design Project: Electrospun Coaxial Fiber Meshes for Cancer Treatment

Designed and fabricated spinneret capable of producing coaxial, non-mixed fibers for electrospinning

Formed coaxial loaded fiber meshes loaded with hydrophilic core solution and hydrophobic polymer shell

Controlled mesh fiber core diameter and shell thickness through parameter variation

Authored final project report and presented findings to professionals, academic professors, and peers.

Research Project: Designing an Electrocardiogram Based Polygraph

Used skin electrodes connected to a LabView interface to collect electrocardiogram (ECG) data for subjects

undergoing true/false questioning

Analyzed recorded data using MATLAB to identify heart rate trends for true and false responses

Authored final project report including methods, results, analysis, and project review

AWARDS AND HONORS

Tau Beta Pi (TPB), National Engineering Society, member since 2012

Alpha Eta Mu Beta (AEMB), National Biomedical Engineering Honor Society, member since 2012

Biomedical Engineering Society (BMES), member since 2012

Boston University Engineering Scholars Program

Prize Essay Award, Boston University WR: Journal of the Arts and Sciences Writing Program, Issue 2 (2009-

2010)

DAVID E. CONEGLIANO 732-546-6974 • 33 Harry Agganis Way, Box 9279, Boston, MA 02215 • dc21@bu.edu

OBJECTIVE: To obtain a summer internship in the healthcare field; I will be attending graduate school for biomedical

engineering in the fall.

EDUCATION

Boston University College of Engineering Boston, MA

B.S. in Biomedical Engineering, Cum Laude May 2013

Concentration in Nanotechnology

Technische Universität Dresden Dresden, Germany

Engineering Study Abroad Program, 20 credits Feb-Jul 2011

Relevant Courses

Product Design and Innovation, Systems Physiology, Biological Transport, Software Engineering, Nanomaterials &

Nanotech, Business of Technology Innovation, Nanoscale Processes, Signals & Systems, Biomedical Measurements

PROFESSIONAL EXPERIENCE Biogen Idec Cambridge, MA

Bioanalytical Assay Development Intern Jun-Aug 2012

• Successfully undertook challenge to develop an original immunoassay to detect neuro filament-heavy protein in

cerebrospinal fluid, a protein that correlates with neuronal damage.

• Presented project in department meetings, collaborated with colleagues, and participated in a poster presentation.

Fraunhofer Center for Manufacturing Innovation Boston, MA

Research Assistant Jan-May 2012

• Multidisciplinary project using macrofluidic devices from Fraunhofer, a microfluidic chip from BU Engineering, and

Surface Enhanced Raman Spectroscopy through the BU Physics department.

• Isolated bacteria from blood by centrifuging samples in devices and combining various reagents.

• Organized large amounts of data into structured Excel spreadsheets for analysis.

Signals & Systems Course Grader, Boston University Sep-Dec 2012

College of Engineering Dean’s Office Student Worker, Boston University Fall 2009-Fall 2011

SENIOR DESIGN PROJECT Targeted Nanoparticles for Sustained Intracellular Drug Release Boston, MA

Nanomedicine and Medical Acoustics Lab, Professor Tyrone Porter Sep 2012—present

• Synthesized pH sensitive PEG chains via a hydrazone linker and designed testing experiments.

• Synthesized hybrid lipid-polymer nanoparticles loaded with anti-cancer drug doxorubicin with two other students.

• Authored project proposal and presented final results at BU’s Senior Design Conference.

TEAM-BASED COURSEWORK Coronary Stent Product Design Project, Boston University Boston, MA

Team Leader Sep-Dec 2012

• Led a team of three, analyzed a marketed coronary stent design, materials, and properties.

• Formulated specifications and testing procedures and applied FDA regulations to theoretical product development

cycle including Good Clinical Practices, Quality System Regulation, PMA, and IDE.

• Composed product proposal that included background information to projected clinical trials and presented project.

Business of Technology Innovation Project, Boston University Boston, MA

President Jan-Apr 2012

• Led a team of four students and organized team meetings, assigned duties, and aided with product design.

• Drafted a full-length business plan and directed a PowerPoint presentation of product and business.

SKILLS Computer: C++, MATLAB, LabScribe, GraphPad Prism, SigmaPlot, LaTeX, SoftMax Pro, Microsoft Office, Windows 7, 8

Lab: ELISAs, immunoassays, cell culture, spectroscopy, microscopy, gel electrophoresis, reagent preparation, agar

plate making, autoclaving, PCR, working with ECGs and EOGs, bacterial transformation

PROFESSIONAL ASSOCIATIONS & PERSONAL ACTIVITIES

Biomedical Engineering Society (BMES) 2009-Present

Society of Hispanic Professional Engineers (SHPE) 2011-Present

College of Engineering Inspiration Ambassador for the Technology Innovation Scholars Program (TISP) 2012-Present

Sailing, graphic design, computer building

Brittany Culpepper brittany.c.culpepper@gmail.com Current Address: 301-247-7720 10 Buick Street Boston, MA 02215 EDUCATION Boston University, Boston, MA 2009-PRESENT Major: Biomedical Engineering Minor: Business Administration Boston University Trustee Scholar (full tuition academic scholarship) RELEVENT COURSEWORK § Molecular Biotechnology, Signals and Systems, Control Systems, Invention, Product Design and Innovation, Biomolecular Architecture, Epigenomics, Biotransport § Dynamics of Leading Organizations, Managerial Accounting, Financial Accounting, European Capital Markets. International Business and Economics WORK EXPERIENCE Beyond Networking and Cobine Carmelson Ltd, London, UK June 20-August 2008 Intern § Re-did website for both companies § In charge of social media management for both companies Breton Bay Pool, Leonardtown, MD May 2007-August 2009 Head Coach of Breton Bay Swim Team § Instructed children from ages 4-18 in swimming skills of various difficulties § Organized swim meets and volunteers § Oversaw coaching staff and led team meetings § Assisted with finances

St. Clements Medical Care, Leonardtown, MD June 2006-August 2008 Office Intern ACTIVITES Sigma Kappa Sorority Delta Chapter January 2010-PRESENT President January 2012 – December 2012 Vice President of New Member Education January 2011-December 2011 Public Relations Chair May 2010-December 2010 Boston University Aural Fixation A Cappella Group January 2010-PRESENT Music Director of group September 2010 – PRESENT Boston University Women’s Rowing Team September 2009-January 2010 Competed in division 1 races, representing Boston University Engineering Dean’s Host Tour guide for perspective students for Boston University’s College of Engineering SKILLS AND HONORS § Proficient in Microsoft Office, Adobe, Basic HTML, MATLAB § Basic French and Italian § Red Cross CPR for the Professional Rescuer, Lifeguard, and Community, First Aid and Safety § 3 time Scholastic All-American for USA Swimming § Engineering Dean’s List § Studied in Italy during the summer of 2010 and England during the summer of 2011

Robert A. Dalgarno 50 Crowninshield Rd.

Brookline, MA 02446

617-785-0402

radalgar@bu.edu

OBJECTIVE Research experience in Biomedical Engineering that will utilize my skills

in design and technology.

EDUCATION Boston University College of Engineering Boston, MA

Candidate for Bachelor of Science in Biomedical Engineering May 2013

Relevant Coursework

Medical Imaging, Optical Microscopy, Control Systems, Fluid Mechanics,

Molecular Cell Biology and Biotechnology, Electric Circuit Theory, Stem

Cells and Cloning

SKILLS MATLAB, Linux shell, Molecular Biology laboratory techniques:

miniprep, molecular cloning (cell and PCR-based), Magnetic Resonance

Imaging: phantom construction, pulse sequence design and image

processing, Optical Microscopy: fluorescence, phase contrast, differential

interference contrast, confocal, total internal reflection.

EXPERIENCE Summer Intern June-August 2009

ARIAD Pharmaceuticals, Inc. Cambridge, MA

Research Technology Department: Computational Chemistry

Processed chemical vendor catalogs to build an internal virtual

screening compound collection

Performed virtual compound screening using Schrödinger software

package and shell tools

Presented methodology and findings to Computational Chemistry

department meeting

PROJECTS Designed, constructed, scanned and analyzed data from an iron-doped

agarose phantom for use in diagnosing liver iron overload. Gained

experience with imaging at 3 Tesla field strength and processing data in

Mathcad.

ACTIVITIES BU Cycling Racing Team, member since 2009

Multiple computer builds; extensive knowledge of PC hardware and

troubleshooting

Electric and acoustic guitar, including the design and assembly of a parts-

built guitar.

Christian Dorman (808) 286-6408

cmdorman@bu.edu Education: Boston University College of Engineering Expected Graduation May 2013 with Double Major

Electrical Engineering (3.86 GPA in relevant coursework)

Biomedical Engineering (3.50 GPA in relevant coursework)

2009 Engineering Scholars Scholarship received from Boston University

Spring 2012, Fall 2011, and Fall 2009 Dean’s List Work Experience: Boston University School of Management IT Student Consultant September 2009 – Present Work with students and faculty assisting with computer issues including network connections, hardware malfunctions, and general maintenance. Boston University Pathology Laboratory Lab Assistant January – August 2010 Worked with senior university researchers and graduate students to develop new plated cell imaging technologies. More specifically, a device capable of stretching plated cells without sacrificing the ability to image them. My responsibilities included substrate preparation, cell culturing, and cell imaging, as well as the subsequent image processing involving ImageJ. Pertinent Skills: Experienced with Matlab, C++, Verilog, and PSpice. Familiar with Java. Knowledgeable in the mathematical techniques of digital signal processing, control theory, logic design, electronics, thermodynamics, electromagnetism, and mechanics. Relevant Coursework and Projects: Currently developing a sonar based mobility aid for the blind as part of my senior thesis. Device utilizes a custom PCB for communication with receiving and emitting transducers and is controlled digitally using Matlab for signal transmission, collection, and processing. Programmed a vocoder for simulating human speech using Matab in signal processing courses. Led a group programming project to create a game using C++ and Java on Andoid OS. Used Matlab extensively in biomedical instrumentation lab courses involving projects modeling physiological systems using collected data. Programmed various projects and a game for an FPGA using Verilog. Developed a program to control a computer cursor with eye movements from EOG signals processed using Matlab.

GHASSAN KARA gkara@bu.edu | +1 617 794 6860

HIGHLIGHTED SKILLS

• Hands-on experience evaluating and advising technology start-ups • Successful team player and leader; experience leading groups of people in different work environments • Excellent communication skills, fluent in three languages

EDUCATION

Boston University - College of Engineering Boston, MA, USA Candidate for Bachelor of Science in Engineering May 2013

• Major in Biomedical Engineering | Concentration in Energy Technologies • Major GPA: 3.87/4.00 | Concentration GPA: 3.80/4.00 | Cumulative GPA: 3.60/4.00 • Dean’s List: all semesters • Honors: Tau Beta Pi (Engineering Honor Society) | Alpha Eta Mu Beta (AEMB) National Bioengineering Honors Society

Lycée Francais International Georges Pompidou Dubai, UAE • High Honors Recipient, French Scientific Baccalaureate June 2009 • Student Body President (represented over 1200 students) | Class President

Harvard Secondary School Program Cambridge, MA, USA • Course Completed: Intensive Introduction to Programming using Java June – July 2008

WORK EXPERIENCE

Boston Scientific Corporation (BSC) Natick, MA, USA Summer Analyst, Corporate Strategy and Operations May-August 2012

• Spearheaded effort to determine BSC’s next offshore low-cost manufacturing location as part of overall supply chain strategic objectives; designed macroeconomic comparative model to rank candidate countries based on market research

• Engineered comprehensive financial projections to model startup-to-operation costs in each candidate country; presented my recommendations to senior management with a $100M budget

• Discussed BSC’s potential investment based on my models with country ambassadors and government agencies • Benchmarked BSC’s respective divisions with competitors; traced international manufacturing and supply chain activities

• Conducted high-level analysis focused on defining BSC’s competitive market strategies

• Supported BSC’s global supply chain optimization effort; designed various cost-benefit models to evaluate and optimize different manufacturing, sterilization, and distribution configurations

Tamer Frères. Siemens Medical Beirut, Lebanon Summer Rotational Intern (Engineering, Strategy) June-July 2010

• Identified potential customers and developing strategies to penetrate local market with cutting-edge medical devices • Supported a team of technical specialists to set up and operate a Linear Accelerator at leading local hospital • Devised equipment implementation schedule

LEADERSHIP AND EXTRACURRICULAR ACTIVITES

Technology Entrepreneurship Club, BU (TEC) Boston, MA, USA Co-President, Co-founder May 2011 – Present

• Increased Boston University’s College of Engineering entrepreneurship funding by 275% within six months • Led Boston University’s $15,000 Technology Entrepreneurship Business Plan Competition (“The 15K”) • Established a growing network of tech-entrepreneurship enthusiasts at BU

Boston University Undergraduate Consulting Club Boston, MA, USA Co-founder March 2013 – Present

The Help Humanity Foundation Dubai, UAE Co-founder May 2008 – June 2009

• Established a non-profit organization for workers in Dubai, UAE

ADDITIONAL SKILLS & INTERESTS

Computational Skills: Java, Microsoft Excel, Microsoft PowerPoint, Microsoft Word, MATLAB Languages: English, French, Arabic, Basic Spanish Interests: Entrepreneurship, Technology, Travel, Photography, Philosophy Hobbies: Basketball, Wakeboarding, Snowboarding, Hunting, Fishing

Current Address 75 Peterborough St. Apt #101 Boston, MA 02215

University Address Boston University One Silber Way Boston, MA 02215

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VERONICA FALLER 5 Lantern Lane, North Reading, MA 01864 vfaller@bu.edu 978.886.8794

EDUCATION AND AWARDS Boston University College of Engineering Boston, MA Candidate for Bachelor of Science in Biomedical Engineering May 2013 Magna Cum Laude Lutchen Fellowship Recipient 2012

Boston University School of Medicine Boston, MA Candidate for Doctor of Medicine May 2017

Relevant Coursework: Biotransport, Human Physiology, Molecular Cell Biology, Signals and Systems, Control Systems, Solid Biomechanics, Thermodynamics, Organic Chemistry, Engineering Mechanics, Logic Design, Electric Circuit Theory LABORATORY EXPERIENCE Research Assistant (Senior Design) August 2012 – Present Zaman Lab for Engineering Education and Development Boston, MA

• Engage in the robust design of a bubble CPAP machine for treating childhood pneumonia in developing countries using lower cost materials, a sustainable power source, and calibration for children up to five years old.

Research Assistant January 2010 – August 2012 Galagan Lab Boston, MA

• Participated in the study of the gene regulatory network and functional evolution of M. tuberculosis. • Performed molecular cloning of M. tuberculosis, M. smegmatis and M. bovis transcription factor coding genes. • Verified induction of M. tuberculosis, M. smegmatis and M. bovis transcription factors coding for various

functions, including inhibition of cell growth (toxin/antitoxin) and long-term hypoxic survival in the host. • Assisted in Chromatin Interaction Analysis by Pair-End-Tag sequencing (ChIA-PET) optimization to study long-

range DNA interactions facilitated by transcription factors involved in the survival of latent M. tuberculosis. • Prepared mycobacterial DNA for Chromatin Immunoprecipitation Sequencing (ChIP-Seq) to assist in the creation

of a comprehensive map of the regulatory binding interactions between protein and DNA. • Assisted in the cloning of two oscillating systems to measure the expression of the genes AraC, LacI, NitR, and

TetR using GFP expression and ssRA proteasome tags to study the microbial metabolism of M. smegmatis. OTHER EXPERIENCE Resident Assistant August 2011 – Present Boston University Office of Residence Life Boston, MA Dean’s Host January 2010 – Present Boston University College of Engineering Boston, MA Engineering Student Advisor – Student Advisor Coordinator 2012-2013 March 2011 – March 2013 Boston University Office of Orientation and College of Engineering Boston, MA Ambassador Volunteer January 2010 – August 2011 Brigham and Women’s Hospital Boston, MA

SKILLS Laboratory: Molecular cloning (primer design, PCR, restriction digestion, ligation, heat shock and electroshock transformation), cell culture, protein preparation, two-step Western Blot, Chromatin Immunoprecipitation Sequencing (ChIP-Seq), Chromatin Interaction Analysis by Pair-End-Tag sequencing (ChIA-PET), library preparation, gel electrophoresis, QIAGEN kits (PCR cleanup, gel extraction, and plasmid mini-prep protocol), genomic DNA extraction, E. coli and mycobacteria competent cell preparation, Covaris, MagNA Lyser, BLAST, oscilloscope, signal processing, image processing Computer: MATLAB, Microsoft Office, FileMaker Pro, Verilog ACTIVITIES & AFFILIATIONS Vice President of Alpha Eta Mu Beta, Boston University Chapter (National Biomedical Engineering Honor Society) Member of Tau Beta Pi (National Engineering Honor Society) and the Boston University Synchronized Swimming Club Sang the Star Spangled Banner at four Boston University Men’s Hockey games

Christopher E Fan 134 Woodland Road Hampton, NH 03842 (603) 770-5137 cfan4@bu.edu

OBJECTIVE Steadfast engineering student striving to enter a top graduate engineering program.

EDUCATION Boston University College of Engineering; Boston, MA Bachelor of Science in Biomedical Engineering May 2013 Cumulative GPA: 3.25 - Boston University Dean’s List Spring 2010

Relevant Coursework Signals & Systems, Electric Circuit Theory, Solid Biomechanics, Systems Phys, Molecular Cell Biology & Biotech, Eng Mechanics, Control Systems in Biomed Eng, Design and Manufacture, Nanomaterials & Nanotech, The Business of Tech Innovation, Product Design & Innovation, Intro to Medical Imaging, CAD & Machine Components, Thermodynamics, DNA Structure & Function, Nanometer Processes in Living Systems

PROJECTS Biomedical Measurements Research Project – “Visual Hearing Aid” Fall 2011 • Major contributor within a team of 4. • Developed a visual display of LEDs that recognized and displayed the direction of surrounding sound. • Utilized a band-pass filter circuit and MATLAB code. If a sound direction fell within a certain azimuthal range, the MATLAB

code would emit the frequency assigned to that range, pass it through the circuit, and light up the specific LED that passes the emitted frequency.

Business of Technology Innovation Project – “HydroClear” Spring 2011 • Assumed position of chief executive officer in the development of a novel contact lens case that promotes increased ocular health

through the automatic cleansing of contacts using a clockwork mechanism and synthetic microfibers. • Constructed a business plan for the hypothetical fabrication of our product including viable marketing, manufacturing, and

operations strategies with financial cash flow projections.

EXPERIENCE Boston University Laboratory for Microsystems Technology; Boston, MA July 2012 - Present Senior Undergraduate Research Assistant • Synthesized PEGylated tantalum oxide nanoparticles using top-down microemulsion technique for use as contrast agent for

computed tomography imaging. • Fabricated anodized aluminum oxide template using two-step anodization process to assist in the formation of rod-shaped

hydrogel nanoparticle delivery vehicles.

Brigham and Women’s Hospital; Boston, MA June 2012 - September 2012 Orthopedic Biomaterials Research Intern • Conducted high pressure treatment on vitamin E stabilized ultra high molecular weight polyethylene. • Determined percent crystallinity in pressure treated polyethylene using differential scanning calorimeter. • Compared tensile properties of high dose irradiated high crystallinity polyethylene to conventional polyethylene with an identical

irradiation dose, both containing vitamin E, using an ADMET universal tensile tester.

Boston University College of Arts and Sciences; Boston, MA January 2012 – May 2012 Systems Physiology Undergraduate Teaching Assistant • Assisted in conducting student lab sections. • Led teaching assistant preparatory sessions along with select student lab sections. • Stocked lab with appropriate materials for subsequent lab sections.

SKILLS Laboratory : Gel electrophoresis, PCR, restriction enzyme digestion, cell culture, pulse plethysomgraph, electroencephalography, electromyography, uniaxial tensile testing, optical microscopy, ultrasound, differential scanning calorimetry, nanofabrication

Computer : MATLAB, LabScribe 2, LabVIEW, SolidWorks, ImageJ, LaTeX, MathCAD

ACCOMPLISHMENTS & ACTIVITIES Orthopedic  Research  Society  Annual  Conference  Podium  Presentation  (Abstract)                                                                                                                            January  2013    Boston University Mixed Martial Arts Vice President Spring 2010 –Present Biomedical Engineering Society (BMES) at BU Spring 2010 - Present Boston  University  Chinese  Student  Association                                                                                                                                                                                  Fall  2009  –  Present  Milton  Academy  New  England  Division  Swim  Team                        Fall  2006  –  Spring  2009  

Michael Francis 55 Cottage Farm Rd. Apt 1 Brookline, MA 02446. (520) 490-6625. mcfranci@bu.edu  Education Boston University, Boston, MA Bachelor of Science in Engineering/Pre-Medical, May 2013 Relevant Coursework: Control Systems in Biomedical Engineering, Thermodynamics, Introduction to Neuroengineering, Systems Physiology, Signals and Systems in Biomedical Engineering, Solid Continuum Biomechanics, Electric Circuit Theory, Molecular Cell Biology, and Organic Chemistry 1 and 2, Organizations: Engineers Without Borders, Boston University Biomedical Engineering Society, Engineering Dean’s Host, and Pre-professional Society, Boston University Orchestra Skills Laboratory skills: Thin-Layer Chromatography, NMR, IR, Gas Chromatography, Columns, Extractions, Measurements, Preparation of solutions, Lab Calculations, Mass Spectrometry, Gel Electrophoresis, Mini-Prep, PCR, Gram staining, histological slide preparation, anesthesia of laboratory animals, and Biological Digestion techniques Computer skills: Excel, Microsoft Word, Powerpoint, Labview, ITK-Snap Medical Imager, MathCad, Image J, SolidWorks and MATLAB. Language: Speak and write in Spanish Professional Experience Square and Compass Children’s Rehabilitation Clinic, Tucson, AZ 2007-2009 Volunteer

• Managed the waiting room to ensure efficient patient flow • Took patients back to the exam rooms • Delivered paperwork and messages around the clinic • Monitored patient care in the waiting room

Pima Orthopedics Tucson, AZ 2009-2010 Office Assistant

• Filed paperwork • Answered phones • Called patients regarding upcoming surgeries

Research Experience UMass Memorial Hospital Worcester Department of Neurosurgery May-October 2011 Neurosurgical Intern/Research Assistant

• Lab technician-helped create a stereotactic atlas of a sheep brain for research on Huntington Disease (all work in radiologic imaging)

• Shadowed Dr. Richard Moser in the department of Neurosurgery • Created patient spreadsheet to show patient history and oncological information (tumors/lesions

found, location, tests run, etc.) Boston University Medical Center Biomedical Research Facility November 2011-September 2012 Laboratory Research Assistant

• Lab assistant-working with Dr. James Hamilton in atherosclerotic plaque research • Analysis of angiograms to view apparent vulnerable plaque buildups • Histological slide preparation • Computer NMR analysis of plaque composition using MATLAB GUIs

Boston University Biomedical Engineering Department: Mertz Lab September 2012-Present Research Assistant

• Design optical prototype • Optimize prototype • Construct miniaturized version of prototype in order to have it take phase contrast images with a

cell phone camera

ERIK J. FRAZIER 78 Linden Street • Allston, MA 02134 • 330.309.3925 (cell) • ejf18@bu.edu

--------------------------------------------------------------------------------------------------------------------------------------------------- OBJECTIVE Entry-level engineer with public speaking and presentation experience seeking a position in the consulting industry with emphasis on biotechnology. EDUCATION Boston University College of Engineering, Boston, MA Bachelor of Science in Biomedical Engineering, May 2013 Concentration in Nanotechnology Relevant Course Work: Biomedical Measurements Labs, Systems Phys., Solid Biomechanics, Digital Signal Processing, Electric Circuit Theory, Org. Chemistry, Signals & Systems, Nanotechnology & Nanomaterials, Control Systems in Eng. RELATED EXPERIENCE Research Assistant Integrated Nanophotonics & Biosensors Laboratory, Boston, MA, June 2012-Present • Researched and implemented the optimal conditions to gain maximum binding ratios between antigens, antibodies, and viruses on a gold chip. • Tested different volumes and flow rates of aforementioned solutions, as well as regeneration conditions for the gold chips on a Surface Plasmon Resonance (SPR) machine. • Prepared antibody and chemical solutions at different concentrations and pHs to be tested in the SPR machine. • Presented written and oral data results to other members of the research group, including the principal investigator. • Designed, presented, and explained findings at a poster session. PROJECTS Electromyogram Cursor Control, Fall 2011 • Synthesized Fourier Transform data from electromyogram (EMG) inputs from wrist motion to move a mouse cursor in a 2 person group. • Incorporated an Analog-to-Digital converter to read the analog EMG signal and output a useful digital EMG signal. • Developed MATLAB coding to perform proper cursor movements based on the EMG input from the A-to-D converter. • Created and presented a Microsoft PowerPoint presentation with project results to a Professor, Graduate Teaching Fellows, and other undergraduate students. Electronic Heart Monitor, Spring 2011 • Functionalized a low resistance speaker into a microphone that detected a patients pulse, and illuminated an LED when the pulse was detected as sound vibrations in the microphone. Computer and Linear Circuit Electroocculogram Simulators, Fall 2012 • Constructed a linear circuit to simulate saccadic eye movements using operational amplifiers and MATLAB coding. SKILLS • MATLAB; SPR; Lab View; Microsoft Powerpoint, Word, and Excel; SigmaPlot; Oscilloscope; Wet Lab Techniques

LEADERSHIP ROLES, ACTIVITIES & HONORS Technology Innovation Scholars Program, Spring 2011-Present • Use personal experience and academic knowledge to deliver presentations to high school, and elementary- school students on opportunities engineering degrees offer. Laboratory Teaching Assistant for Nanotechnology Lab, Fall 2012 • Monitored the lab during student’s experiments and helped answer questions and explain concepts of the lab. • Graded student’s submitted lab reports. College of Engineering EK 100 Student Advisor, Fall 2010-Present College of Engineering Dean’s List Recipient, Fall of 2009 and Spring of 2010 Biomedical Engineering Society at Boston University, member since 2009 National Society of Collegiate Scholars, member since 2009

Carolynn M. Gaut 3 Adams Street � Brookline, MA 02446 � Phone: 201-232-4372 � Email: cmgaut@bu.edu

OBJECTIVE EDUCATION

• Boston University College of Engineering, Boston, MA Candidate for Bachelor of Science in Biomedical Engineering with a Concentration in Nanotechnology to be completed in May, 2013

Relevant Coursework: MATLAB, Neuroengineering, Stem Cells and Cloning, Differential Equations, Organic Chemistry, Solid Biomechanics, Signals and Systems, Control Systems Biology, Nanoscale Processes in Living Systems, Fundamentals of Nanomaterials and Nanotechnology, Applications in Bioinformatics, Thermodynamics, Product Development and Design GPA: 3.85/4.0

• Boston University College of Engineering, Graduate Program, Boston, MA Candidate for Masters of Engineering in Biomedical Engineering to be completed in May, 2014 EXPERIENCE

• Senior Design Project September 2012-Present Design of an Image Processing Program to More Accurately Measure Cellular Traction Forces

• Undergraduate Research May 2011 – September 2012 Boston University - Research in cytoskeleton proteins and fibers in living cells; experience with cell culture, microscopy, image processing, and protein tagging; created programs to analyze the data collected

• Laboratory Teaching Assistant September – December 2012 Boston University - Organize, teach, and orchestrate the lab section of the Boston University undergraduate course “Fundamentals of Nanomaterials and Nanotechnology” (ENG EC481).

• Accenture June – August 2012 Interned as a Systems Integration Consulting Analyst on a Project Management team. Work included process documentation and improvement, Sharepoint site creation and maintenance, metric reporting, organization of professional presentations and meetings, and the implementation of a large internal reorganization.

• Team Project: Optical Control of Cursor Movement Spring 2012 Designed a computer program using MATLAB to control a computer cursor using electrooculogram readings from a subject in real time. I worked with four other students and gave a formal PowerPoint Presentation of data and program.

• College of Engineering Student Advisor 2011 Boston University - Advised thirteen undergraduate freshmen in class choices, time management, engineering ethics, and on-campus events.

Proficient in Microsoft Office, Excel, Sharepoint, Python, MS Visio, MATLAB, ImageJ, SigmaPlot HONORS and ASSOCIATIONS

• Tau Beta Pi, Massachusetts Eta Chapter, Engineering Honor Society member since 2012 • Boston University, Dean’s List all semesters; The Order of the Engineer; Biomedical Engineering

Society; Society of Women Engineers; Chemistry Outreach Program 2009-10

VOLUNTEER EXPERIENCE • Marine Science Association Coast Sweep, Beach Clean-up After Hurricane Sandy 2012 • National Intern Day of Service, ExCel for Children’s Art Supplies, Lynn, MA 2012 • Boston Athletic Association, volunteer for Boston Marathon 2011-2013 • Step-Out, fundraised and participated in the memory walk 2010

HOBBIES Boston University Intramural Broomball and Floor Hockey, Hiking, Horseback Riding, Fishing, Running

JOHN GAWEDZINSKI 700 Commonwealth Ave. Boston, MA, Box 3179 (214) 674-1543 jgawed@bu.edu

EDUCATION EXPERIENCE SKILLS RELEVANT CLASSES TAKEN

• Boston University—Boston, MA 09/2009-05/2013 B.S. in Biomedical Engineering, Minor in Electrical Engineering o Dean’s List Awarded 6/7 times; Engineering Scholar; GPA: 3.62 o Undergraduate Research Opportunities Grant awarded for summer of 2012 o Member of Tau Beta Pi and Alpha Eta Mu Beta engineering honor societies

• Biomedical Optics Research Lab, Boston University 09/2011-present Research Assistant for Dr. Irving Bigio o Examined scattering effects as a quantitative tool for classifying cells o Studied medical applications of spectroscopy and optics

• Warren Towers, Boston University 05/2012-present Resident Assistant o R.A. on an engineering specialty floor with 42 undergraduate freshmen o Twenty hours of on-call/office work per week

• Wolbachia Research Lab, Boston University 09/2010-05/2011 Lab Assistant for Dr. Horacio Frydman o Observed interactions of parasitic bacteria Wolbachia with fruit fly cultures o Maintained several different fruit fly species used for experimentation

• Binaural Hearing Lab, Boston University 02/2010-05/2010 Research Assistant for Dr. Steven Colburn o Assisted in designing tests that evaluated patients’ spatial recognition o Worked with MATLAB coding that drove the binaural detection hardware

• Sunset Programming, Dallas, TX 05/2010-08/2010, 05/2011-08/2011 Office Assistant o Managed office organization, scheduled consulting trips, took phone calls

• Experienced with: -C++ -MATLAB -Verilog -JavaScript -SolidWorks -Mathcad

• Leadership and organizational skills acquired from heavy involvement in BU’s M.A.N. project, BU residence life, and engineering honor societies -Organic Chemistry -Fluid Mechanics -Biomaterials -Medical Imaging -Nanomaterials/Nanotechnology -Logic Design -Systems Physiology -Intro to Software Engineering -Electronics

Permanent Address:

16 Whisperwood Ct.

Brownsburg, IN 46112

Suvomita H. Ghosh (317) 690-6487 shghosh@bu.edu

Local Address:

55 Cottage Farm Dr.

Brookline, MA 02446

Education Boston University College of Engineering and College of Arts and Sciences Candidate for Bachelor of Science in Biomedical Engineering, May 2013

Candidate for Bachelor of Arts in Political Science, May 2013

Boston, MA

Relevant Coursework

Signals and Systems, Control Systems, Biomedical Measurements, Environmental Acoustics, Medical

Imaging, Neuroengineering, Thermodynamics, Fluid Dynamics, Biotransport, Systems Physiology

Tel Aviv University Tel Aviv, Israel 01/2011 - 06/2011

Semester Abroad

Selected Projects Senior Project: Alternative Ultrasound Gel for Limited Resource Settings

BU Laboratory for Engineering Education and Development (LEED)

• Designed an alternative ultrasound gel for resource limited settings by investigating the function of ultrasound

devices and gels, determining locally available substitute ingredients, and contacting potential manufacturers.

• Characterized properties and established testing methods for acoustic impedance, electrical resistance, and

bacteriostaticity for ultrasound gel that is feasible within developing countries.

Eye Movement communication via EOG

• Developed and initial method of communication with the eyes by the use of electrooculogram (EOG) data. Subjects were

connected to surface electrodes and their EOG data was recorded as the eyes moved.

• Information was processed through a MATLAB in real time, and the cursor was translated the computer screen. Created a

script that included a calibration test to adjust for each individual subject.

Virtual Acoustic Sound Simulation

• Collected impulses from Center for Image Processing and Integrated Computing database for multiple subjects and directions.

• Scripted a MATLAB code for signal processing that convolved a sound file with the impulses collected the data base to

construct a virtual acoustic sound.

• Analyzed the resulting sounds to determine how its clarity and apparent location varied depending on the data of individual

subjects

Experience Boston University Porter Lab, Undergraduate Researcher Boston, MA 10/2011 – 10/2012

• Generate cancer drug loaded polymers, size particles with dynamic light scattering, and test release at varying pH by use of

high-performance liquid chromatography or spectrofluorometry. Goal is to develop more effective cancer drug delivery.

• Created drug calibration curve and investigated results by comparison to this curve.

Riley Hospital for Children POWER Indianapolis, IN 06/2012-08/2012

• Analyzed existing data on fast frequency questionnaires and metabolic syndrome. Initial preparation to determine success

of autistic children in the study. Drafted doctor’s letters. Shadowing experience with high level of patient interaction in

clinic and operating room.

BU Medical Center Endocrinology Lab, Laboratory Assistant Boston, MA 10/2010 - 12/2010

• Prepared solutions and serum samples, performed tests, and ran lab machinery, data entry laboratory experiments regarding

the impact of testosterone on longevity

Activities and Organizations Global Awareness Project (Vice President), Minority Engineering Society, Society of Women Engineers, Biomedical

Engineering Society, Engineering Dean’s Host; Senior Classical League

Skills Computer: MATLAB, LabVIEW, SigmaPlot, Stata, Autocad, Microsoft Office

Language: Conversational Bengali, Basic Spanish, Basic Hebrew, Latin (5 years)

Laboratory: Nuclear magnetic spectroscopy, infrared spectrometer, gel electrophoresis, column chromatography,

recrystallization, pulse plethysmograph, high performance liquid chromatography, dynamic light scattering

Luka Grujic 210 Parker Hill, Boston MA 617 840 7130 lukagrujic@yahoo.com

Objective

Creative and enthusiastic engineering student with a scientific curiosity striving for a career in the

biopharmaceutical field with interests in drug development, bio-engineering and pathophysiology of

hereditary diseases and cancer.

Education Boston University Biomedical Engineering Program, Boston, MA GPA 3.3

(Top 10 US News and World Report Ranking) Bachelor of Science, May, 2013

Deans List (2011-2013) Top 30% of Class

BU Scholars Full Tuition Scholarship (2009) Select 20 from Boston Public Schools

Tel Aviv University Engineering Program, Tel Aviv, Israel

Semester Abroad (Selected 25 students with GPA higher than 3.0), Spring 2011

Boston Latin School, Boston, MA (2004-2009)

National Honor Society (2009) Top 5% of high school

Relevant Course Work

Systems Physiology, Molecular Bio, Buisness Innovation, ,Product Design (CFR and FDA regulations),

Biomedical Systems & Signals, Control Theory, Muscle Bio, Biomechanics, Muscle Biomechanics

Projects Coaxial Spinneret (Senior Thesis) : Grinstaff Lab

Designed and manufactured a nanofiber electrospinning machine that produces core shell fiber meshes to be

used as a local anti cancer drug delivery system. Optimized flow and solution parameters by validating

physical properties of mesh. Proved coaxial mesh efficiency is greater than mix mesh.

Parallel Microfluidic Cytometer (PMC) : Ehrlich Lab

Research assisant: validated a novel imaging flow cytometer for use in cell based assays to determine

intracellular localization of transcription factor (nuclear vs. cytoplasm). Developed best practice protocol to

optimize sample throughput in a massively parallel configuration (16 samples imaged simultaneously). Beta-

testing of data acquisition and analysis software; contributed to design of software and experiments.

Hygenex Soap Dispenser : Business Innovation

Co-wrote the business plan for the created product that was intended to help decrease infections throughout

hospitals using a timed system that forces individuals to cleanse for 20 seconds. Developed a virtual

prototype using solid works.

Audio Heart Rate Monitor : Bio Instrumentation

Coding creator for device: using MATLAB developed a program that converted the ECG heart rate signal to

a discrete time wave form and script with computational analysis of data to perform lub and dub audio

sounds at the closure of AV and Semilunar valves.

Skills Lab Instruments: Flow Cytometer, Oscilloscope, A/D Converter, ECG, Coaxial Spinneret

Lab Experience: Cell Culturing, Assays, 7 classes of lab experience, comfortable with lab environment;

Physiology, 2 Chemistry, Cell Bio, Circuit Theory, 2 Physics

Computer Skills: MATLAB, Solid Works, Mathcad, LabView, Pspice, Excel, PowerPoint, Microsoft Word

Languages: Serbian, Spanish

Experience Caller: Boston University Telefund Boston, MA (2009-2011)

● Raised over $ 35,000 in funds for BU by contacting BU alumni and student parents.

Valet : Ultimate Parking Boston, MA (2008-2009)

● Responsibility for other people’s assets; courteous greetings to various clientele. Learned to work

efficiently in teams while under stress and constant time constraint.

Honors &

Activites

●BU Biomedical Engineering Society (2011) Prof. Networking group

● MVP Varsity Swimming (2007) Best swimmer and results of the season

● Modern Award (2007) No grade lower than B-

●Boston Latin School Library Aid Boston, MA (2007–2009)

Manage books and maintain area

References Man Ching Cheung, Dan Ehrlich : Available upon request.

Cory Haselmayer 8438 Sweet Mill Lane, Clay NY 13041

315-447-6270

coryhase@bu.edu

Professional Experience:

Beth Israel Deaconess Medical Center Boston, MA Research Assistant September 2012-May 2013

Working with trabecular bone structures to determine the intrinsic properties of cancellous bone by removing

errors and artifacts in micro computed tomographic images in MatLab as a senior design project

Spinning Wheel Restaurant Syracuse, NY

Banquet Cook May 2012- August 2012

Experienced in safe operation of commercial food service equipment, including deep fryers, ovens, cooktops, and

slicers

Odyssea Watersports Ocean City, MD Jet Ski Guide May 2011- August 2011

Supervised and provided instruction to customers

Emergency Jet Ski maintenance

Subway Boston, MA

Sandwich Artist September 2009- May 2010

Responsible for food preparation, clean up and register

Meticulous worker; attentive to quality and detail

Performed multiple tasks smoothly and efficiently in a fast-paced environment

Education:

Boston University Boston, MA

Bachelor of Science in Biomedical Engineering with Pre-Medical

Graduating May, 2013

Liverpool High School Liverpool, NY

Graduated with Honors 2009

Achievements:

Dean’s List Eagle Scout National Honor Society FIRST Robotics Team People to People Ambassador

Fall 2012 July, 2009 2008 2008 Traveled to Australia 2007

Related Coursework: Calculus I, II, III Physics I, II Molecular Cell Biology Logic Design

Control Systems Probability Biomedical Measurements Fluid Dynamics

General Chemistry Differential Equations Systems Physiology Molecular Architecture

Thermodynamics Medical Imaging Organic Chemistry Project Design and Innovation in BME

Additional Skills: MatLab , SolidWorks, Verilog, SigmaPlot, Autodesk Inventor, MathCad, CAD Manufacturing, Microsoft Office Suite

References Available Upon Request

Benjamin Walton Hertz 58 Perkins Street ● Stoneham, MA 02180 ● (617) 529-3061 ● bhz@bu.edu

Objective_________________________________________________________________________________

Extremely motivated, entry-level Engineer with research experience seeking a full time position at a Medical Device company

Education________________________________________________________________________________

Boston University, Boston, MA

Bachelor of Science in Biomedical Engineering, May 2013

Current GPA = 3.46 / 4.0 Dean's List Tel Aviv University, Tel Aviv, Israel

Study abroad sophomore year, January - June 2011 20 engineering credits earned

Related Coursework Biomaterials, Devices and Diagnostics Design, Tissue Engineering, Solid Biomechanics, Systems Physiology, Biotransport, Organic Chemistry (with lab), Product Design and Innovation, Engineering Computation (MATLAB with lab), Signal Processing (with lab), Thermodynamics, Control Systems (with lab), Differential Equations, Electric Circuit Theory.

Significant Projects________________________________________________________________________ Senior Design – Accurately modeling kinematic movement and contact pressures within the shoulder joint using a

cadaveric model, with the help of Tekscan pressure sensing strips, Motion Planner software, and Qualysis motion capturing software.

Biomedical Measurements – Designed polygraph examination using surface electrodes connected to a LabView interface to collect electrocardiogram data, and a MATLAB program to analyze measured heart rate fluctuations during true/false questioning. Culminated in a formal report and presentation in front of classmates.

Business Innovation – CFO of company producing revolutionary hygienic hand washing system, that would help to reduce infection rates in hospitals by forcing users to adequately scrub hands for the recommended amount of time. Currently investigating patent claim for product. Culminated in a formal business proposal and presentation in front of classmates.

Related Work Experience___________________________________________________________________

Beth Israel Deaconess Medical Center, Boston, MA May 2012 – August 2012

Research Assistant

Assisted in the design and completion of experiments regarding proximal biceps tenodesis repair methods and meniscal repair methods using an Instron 8511 load frame and a LabView interface, which resulted in two papers currently under review

Began work on project to accurately model shoulder movement using a cadaveric sample.

Assisted in cadaveric surgeries

Awards and Accomplishments_____________________________________________________________________

Alpha Eta Mu Beta (Biomedical Engineering Honor Society)

Secretary of Boston University Chapter of the Biomedical Engineering Society

Secretary of the College of Engineering Student Government at Boston University

Biomechanical Characterization of Proximal Biceps Tenodesis Using Unicortical Button Fixation: BMES National Conference Poster Presentation, Atlanta, GA

Golf Instructor at Mt. Hood Golf Course in Melrose, MA

2012

2012-2013

2012-2013

October 2012 2007-2012

Technical Skills___________________________________________________________________________

MATLAB software Qualysis software

ImageJ Motion Planner

Disciplined laboratory technician Solidworks

JOHN HOANG 134 Schoolhouse Lane, Portsmouth, Rhode Island 02871

(401) 286-7040 | hoangj40@bu.edu OBJECTIVE I am a highly motivated biomedical engineering student looking to obtain a position within the medial device industry. EDUCATION Boston University, Boston, MA Bachelor of Science Degree: Biomedical Engineering - Expected Graduation May 2013 RELATED COURSES: Transport Phenomena, Biomedical Measurements, Medical Imaging, Intellectual Property, Business Technology Innovation Control Systems, Signals and Systems, Device and Diagnostics Design PUBLICATIONS • B. Bleier, A. Nocera, H. Iqbal, J. Hoang, R. Feldman, “P-glycoprotein Functions as an Immunomodulator in Human

Primary Nasal Epithelial Cells”, The Journal of Allergy and Clinical Immunology, 2013 February. COURSE PROJECTS Senior Design Project - In vitro  Mucosal Membrane Culture Model for Drug Delivery: Utilize an in vitro cell-culturing model using mucosal tissue taken from human patients. Used proper cell culturing techniques, protein and accumulation assays, and enzyme linked immunosorbent assays to determine effective inhibition of p-glycoprotein for development of efficient drug delivery pathway to the central nervous system. Product Design & Innovation Project – Aortic Heart Valve: Worked with a team of three to go through proper FDA regulations, failure mode effects analysis, and necessary intellectual property pertaining to a Class 3 aortic heart valve in order to bring the device into market. WORK EXPERINCE Naval Undersea Warfare Center, Newport, RI Naval Research Enterprise Research Program (NREIP) Intern 05/11 – 08/11 • Participated within team environment in the design, development, and troubleshooting of Common System Radio Room (CSRR)

equipment for all United States submarine classes. • Involved in the design Automatic Identification System (AIS) Antenna Interface Unit for 688 Class Submarine. Boston University Medical Center, Boston, MA Research Assistant 09/09 – 05/10 • Assisted study physicians and various technical members of the Androgen Clinical Research Unit to conduct clinical

research on effects of selective androgen receptor modulators on humans. • Monitored and recorded subject progress over entire study including screening potential study subjects and handling

confidential subject information.

Naval Undersea Warfare Center, Newport, RI Science Engineering Apprentice Program (SEAP) Intern Summers 2008 - 2009 • Analyzed environmental qualification test (EQT) requirements, reviewed test data and defined changes required in

new testing requirements of Virginia Class Submarine Radio Room. • Instrumented and tested the software defined radio (SDR) receiver. • Generated Java coding and Extensible Markup Language (XML) for a vessel monitoring system to track ships and

monitor their activities around the world in supporting Lisbon: Maritime Domain Awareness. COMPUTER & TECHNICAL SKILLS Software: MATLAB, MS-Visio, SigmaPlot, ImageJ, PSpice, Solidworks Equipment: Spectrum analyzer, Oscilloscopes, Signal generator Skills: Soldering, Cable manufacturing, Cell culturing, ELISA, PCR ACTIVITIES • President, College of Engineering Senior Class, Fall 2012 – Present • Treasurer, Society of Asian Scientist and Engineers

University Address: 16A Winslow Road Phone: (408) 888-9076

Brookline, MA 02446 Email: ayushj@bu.edu

Home Address: 21888 Villa Oaks Lane

Saratoga, CA 95070

Education

The Harker School: High School Graduation: May 2009

Boston University: College of Engineering

B.S. Biomedical Engineering Expected Graduation: May 2013

Relevant Coursework: (Indicates Lab Component)

Nanometer Scale Processes in Living Systems, Neuroengineering, Transport Phenomena in Biological Systems,

Optical Microscopy of Biological Materials, Thermodynamics and Statistical Mechanics, Signals and Systems,

Control Systems, Cell Biology/Biotechnology, Systems Physiology, Biomedical Measurements, Biological

Measurements, Engineering Computation (MATLAB), Product Design and Innovation, Organizing for Design and

Innovation, Intellectual Assets, Organic Chemistry I & II, Linear Algebra, Probability, Engineering Mechanics,

Electric Circuit Theory, Engineering Physics I & II, General Chemistry I & II

Work Experience

September 2012-Present: Undergraduate Researcher – Harvard-MIT HST Khademhosseini Lab (Cambridge, MA)

Design and development of heart-on-a-chip technology (microfluidic immunoassay for cardiac biomarkers). - Skills gained in: microfluidic chip design (CAD), microfluidic chip fabrication (PDMS), cell culturing,

immunofluorescence, ELISA, fluorescence microscopy

May-August 2012: Intern – Prysm, Inc. (San Jose, CA)

Developed comprehensive market analysis of Prysm’s top competitors in the large format display industry.

- Analyzed the financial, marketing, sales, and technological strengths and weaknesses of competitors

- Delivered 11 unique final presentations to the Prysm Executive team and sales force

May-August 2011: Intern – Nextbio, Inc. (Cupertino, CA)

Traced pathways between genetic mutations (SNPs), diseases, and pharmaceutics.

- Researched and compiled biomedical databases centered around:

o SNP (single nucleotide polymorphism) to disease relationships

o FDA approved pharmaceutics to disease relationships

June-August 2010: Intern – BioImagene Inc. (Sunnyvale, CA)

Designed a comparative testing mechanism for high resolution digital images.

- Utilized “R” (programming language) to perform statistical analysis and develop graphical models

- Wrote and presented a 30+ page white paper analyzing the results of the research

June-August 2008: Intern – BioImagene Inc. (Sunnyvale, CA)

Performed hardware testing and debugging of BioImagene’s iScan 2.0 technology.

Projects

September-December 2012: Product Development Term Project

Reverse engineering of a mitral valve prosthetic to establish a comprehensive design and development plan.

This includes feasibility/testing protocols, competitive analysis, patent review, and regulatory approval. September-December 2011: BU Biomedical Measurements Lab

Design and development of specialized visual aid technology for patients suffering from Locked-

in syndrome. Application of electrooculograms, circuit theory, and MATLAB.

Skills / Lab Experience

Engineering: MATLAB, CAD/Solidworks, ECG/EOG/EMG systems, ultrasound, oscilloscopes,

spectrophotometers, spectroscopy, frequency and phase analysis

Biology: PCR analysis, GFP (green fluorescent protein) expression, molecular cloning (restriction enzyme

digestion, ligation and transformation, and time series analysis), bacterial growth analysis, protein folding analysis

Microscopy: Zernike phase contrast, Nomarski DIC imaging, fluorescence microscopy, Fluorescence Correlation

Spectroscopy (FCS), Ca2+ imaging, TIRF Imaging, Confocal microscopy, STED microscopy

Chemistry: electrochemistry, NMR and IR spectroscopy analysis, synthesis of 1,4-Diphenyl-1,3-butadiene,

synthesis of polyester/nylon/and polystyrene, phase transfer catalysis, benzoin isolation, TLC testing, synthesis of

isopentyl acetate, synthesis of methylcyclohexene

Ayush Jain

Lijia Jin

1079 commonwelath ave, APT 246, Boston, MA 02215 • sora036@bu.edu • 617-642-8662 US. Permanent Resident

OBJECTIVE

To obtain an internship position that utilizes analytical and technical skills combining the knowledge in biomedical

engineering.

EDUCATION

Boston University, Boston, MA. B.S. in Biomedcial- Engineering, Pursuing concentration in nanotechnology

class of 2013

Releveant course work: Signals and System, Control system in biomedical engineering, Thermodynamics, Fluid

Mechanics, Fundamentals of Nanotechnology, Business and innovation in technology, System physiology, Electric

Circuit Theory，introduction to neuron engineering, Engineering economy。

WORK EXPERIENCE

Shanghai CHEMPARTNER June 2011-September 2011

Research assistant (internship)

Performing molecular cloning on B cells of immune system

Drug test on B cells

Doing research on new sleep-control drugs targeting GABA receptor

Doing marketing research on potential markets for new sleep-control drugs in China

Ali Khademhosseini Lab September 2012-May 2013

Research assistant (Senior Project)

Building a bioreactor used for cardiac tissue engineering for the lab coordinator

Work with expertise in biomedical engineering and help them with their projects

Gained various resources from the lab and learned about a large number of advanced technology in biomedical

engineering.

PROJECT EXPERIENCE

Carbon Nanotube Water filtration system SEP 2011-DEC 2011

Individual Project

Analyzing the advantages of newly developed materials: carbon nanotubes

Doing research for the current Carbon nanotubes based water filtration system product

The effect of Melatonin and Taurine based drinks on Human body NOV 2011-DEC 2011

Group Project

Three popular energy drinks on the market were chosen

EKG, EOG and EMG data were acquired after subject consume the drinks and all the data were fully analyzed

LEADERSHIP SEP 2011- present

Boston University Chinese Students and scholars association

Chair of Student Affair

Helping new Chinese students on the orientation

Organizing and hosting different events in traditional Chinese festivals

Skills and additional experience Computer: Matlab, PASCAL, Q-basic, solid works, Sigma-plot, Photoshop, Fireworks, Microsoft Office Suite Language: Fluent in English. Mandarin, Japanese

Kyle Jones 10 Buick Street, Box 8501, Boston MA 02215 Phone: 440.668.0666 Email: ktjones@bu.edu

OBJECTIVE Highly motivated senior seeking employment in the field of Engineering or Medical research and outreach EDUCATION Boston University, College of Engineering, Boston, MA Bachelor of Science in Biomedical Engineering, Summa Cum Laude; May 2013 GPA: 3.85 out of 4.00, Dean’s List: Fall 2009, Spring 2010, Fall 2010, Spring 2011, Fall 2011, Spring 2012, Fall 2012 Kenneth R. Lutchen Distinguished Fellow Dublin City University, Dublin, IE Semester-long Study Abroad Program, Fall 2011 Relevant Coursework: Systems Physiology, Signal Processing, Organic Chemistry, Control Systems, Electric Circuit Theory, Immunology, Statistics and Probability, Thermodynamics, Image Analysis and Processing, Intro to Global Health, Transport Phenomena in Biological Processes

SENIOR PROJECT: “A Real-time Feedback System for Landing Pattern Modification of the Injured Runner,” Spring 2013 • Designed a device to measure the foot strike patterns of barefoot runners for gait retraining programs • Selected, implemented, and assembled electrical hardware for the device using microcontrollers and sensors • Wrote algorithms for the microcontroller device and computer display program for real-time feedback • Will analyze the efficacy of device through a validation study and present final results at BU’s Department of Engineering

“Senior Design Project Conference” in May 2013 RELATED EXPERIENCE Research Assistant National Emerging Infectious Diseases Lab Boston, MA June 2012- Aug. 2012 • Studied the transcriptional factor regulatory network of Mycobacterium tuberculosis (M.Tb) through the identification of

transcription factor binding sites (TFBS) to better understand the regulatory mechanisms underlying several adaptations of M.Tb

• Developed a protocol named Chromatin Immunoprecipitation using Pair End Tag sequencing (ChIA-PET) in non-pathogenic Mycobacterium smegmatis to determine long range chromatin-transcription factor protein interactions

Researcher BU International Genetically Engineered Machine Competition Boston, MA June 2011- Aug. 2011 • Studied the transcription factor genes in Mycobacterium tuberculosis using computational tools and recombinant DNA

technology • Assemble DNA plasmids, transformed the plasmids into E. coli cells, and grew the bacteria • Designed the DNA constructs, gave oral presentations at weekly lab meetings, and performed various other jobs Research Assistant University Hospitals Cleveland, OH June 2010 - Aug. 2010 • Grew and diluted samples of methicillin-resistant Staphylococcus aureus (MRSA), performed surgical preparation, and

assisted in surgical procedures of rats and pigs for use in a study of repairing ventral hernias with biological and synthetic meshes in the presence of infection

• Initiated a retrospective study of the effect of thoracic epidurals on post-operation complications in hernia repair patients

SKILLS Computer: MATLAB, Arduino and Processing software, Vicon Motion Capture System, Visual 3D software Laboratory: PCR, Western Blot, Molecular cloning techniques, rat handling ACTIVITIES and ASSOCIATIONS Tutor for the College of Engineering bWell Center Volunteer, Boston Medical Center Tau Beta Pi Engineering Honor’s Society Alpha Eta Mu Beta Biomedical Engineering Honor’s Society Winter Outreach Program Student Support Network Model Airplane Flyer Rowing Instructor and Coach Boston University Division I Men’s Varsity Crew

SNEHASEEL KAKILETI

1026 Grandview Ave, Westfield, NJ 07090 • s.kakileti@yahoo.com • (908) 456-2514

EDUCATION Boston University College of Engineering Boston, MA

Bachelor of Science in Biomedical Engineering with premedical requisites May 2013

Relevant Coursework: Biomolecular Architecture | Product Design and Innovation | Thermodynamics | Biomedical

Measurements | Biological Signals and Systems | Biological Control Systems | Systems Physiology | Cell Biology |

Organic Chemistry | Fluid Mechanics | Engineering Mechanics | Differential Equations | Analytical Chemistry COURSE PROJECTS Senior Design Project: Microfluidic Bioreactor for Assessment of Pharmaceutical Cardiac Toxicity 2012-2013

Worked at Harvard-MIT Division of Health Sciences and Technology under Prof. Ali Khademhosseini.

Designed and fabricated PDMS-based microfluidic bioreactor mimicking vascular environment.

Designed and developed on-chip enzyme-linked immunosorbent assay (ELISA) for detection of cardiac specific

protein, troponin T.

Designed and performed experiments to evaluate developed troponin assay. Product Design and Innovation Project: Medtronic Hancock II Mitral Valve Replacement Fall 2012

Formulated product development plan for Medtronic Hancock II Valve following FDA requirements.

Included complete patent submissions, plans for preclinical testing, clinical trials and post market surveillance of

device as well as investigational device exemption and pre-market approval forms. Biomedical Instrumentation Final Project: Electronic Stethoscope Spring 2012

Designed and developed electronic stethoscope hardware to detect and measure heart pulse.

Programmed MATLAB code to filter and analyze acquired heart rate signal.

Compared calculated heart rate to literature values for diagnosis of irregular heart beat. Mechanics Final Project: Truss Project Fall 2011

Designed and constructed planar truss.

Programmed MATLAB script and WinTruss model to analyze member forces and predict critical member and failure

load. EXPERIENCE New Jersey Neuroscience Institute at JFK Medical Center; Edison, NJ

Research Assistant Summer 2011

Abstract titled “Neuroprotective Role of Endogenous Serum Magnesium on the Severity of Spontaneous

Intraparechymal Hemorrhage” was accepted to the 64th Annual Meeting of the American Academy of Neurology.

Collected magnesium levels from stroke patient database and evaluated severity of stroke using University of

California intracerebral hemorrhage score.

Performed correlation coefficient analysis to assess neuroprotective benefit of magnesium against cerebral ischemia. SKILLS Computer: MATLAB, Microsoft Word, Excel, PowerPoint, AutoCAD, LabVIEW, Image J, WinTruss

Laboratory: Microscopy, Dissection, Distillation, Chromatography, Western Blotting, NMR, IR, UV-Vis Spectroscopy,

Circuitry, Mechanical and Biomaterial testing, Ultrasound imaging, Physiological Analysis ACTIVITES Sigma Beta Rho Fraternity Inc.; Boston University, Boston, MA Fall 2009 - Present

Treasurer (2009-2011) Vice President (2011-2012)

Multicultural Greek Council (MGC); Boston University, Boston, MA 2011 - 2012

Fraternity Representative

Boston University India Club; Boston University, Boston, MA 2011 - 2012

Jake P. Kallarackal 405 Peakham Rd Sudbury, MA 01776 (978) 496-0408 jpkalls@bu.edu

EDUCATION Boston University, College of Engineering Boston, MA Bachelor of Science: Biomedical Engineering, May 2013 Concentration: Nanotechnology Minors: Chemistry and Biology GPA: 3.46/4.0

RELEVANT COURSEWORK Intensive General and Quantitative Analytical Chemistry, Organic Chemistry, Thermodynamics, Electric Circuit Theory, Principles of Molecular Cell Bio and Biotechnology, Biological and Environmental Acoustics, Engineering Computation (Matlab), Principles of Nanotechnology, Engineering Mechanics, Advanced Signals and Systems, Speech Signal Processing

SKILLS SUMMARY Computer: Microsoft Office (Word, Excel, and PowerPoint) & Matlab Laboratory: Cleanroom Photolithography, UV/VIS Spectroscopy, Atomic Absorption Spectroscopy, Electrochemistry, Titrations, Infrared Spectroscopy, Nuclear Magnetic Resonance Spectroscopy, Mass Spectrometry, ECG and EOG usage, Signal filtration, and Circuit Analysis.

PROJECTS Senior Design Project:“Heart on a Chip” - Khademhosseini lab Harvard-MIT HST Worked to design a microfluidic PDMS chip for testing of drug cardiac toxicity. Device implemented an on chip troponin detection system. Responsible for cardiac cell culture preparation, loading of cells, immunostaining, and design of a cell stressing procedure. Additional Projects:

Worked on the programming of a robotic arm for sample transfer, as well as overall operation of a prototype Parallel Microfluidic Cytometer in the lab of Dan Ehrlich

Organized DVD Drive and installation of entertainment center for Christopher’s Haven; a temporary home for cancer patients receiving treatment in Boston. Personally spent over 40 hours working and organizing the project. Recruited over 150 hours of work from others.

Designed and constructed a truss bridge to specified dimensions. Failing weight and point of failure successfully predicted using WinTruss application.

Designed a teaching lab for the implementation of a technology known as Interferometric Reflectance Imaging Sensor (IRIS).

LEADERSHIP, ACTIVITIES, & HONORS

Director of Operations of BU Allocations Board (Responsible for overseeing $700,000 budget) Founded colony of Iota Nu Delta Fraternity Inc. at Boston Univeristy Dancer on three nationally competitive dance teams: BU Bhangra, BU Jalwa, & FAUJ Bhangra Treasurer of Society of Asian Scientists and Engineers Patient transport volunteer at Mass General Hospital Dean’s List 3 Semesters Eagle Scout

463 Park Drive, Apt.10 Boston, MA 02215

ikao@bu.edu • 516-830-1513

EDUCATION Boston University College of Engineering; Boston, MA

Bachelor of Science in Biomedical Engineering; May 2013 Relevant Coursework: Device & Diagnostic Design, Biomolecular Architecture, Intro to Neuroengineering, Product Design &

Innovation in Biomedical Eng., Business of Technology Innovation, Intellectual Property: Technology Creation, Protection & Commercialization, Transport Phenomena in Biological Systems, DNA Nanotech., Electric Circuit Theory, Controls Systems in Biomedical Eng., Thermodynamics & Statistical Mechanics, Signals & Systems, Engineering Physiology

SENIOR CAPSTONE PROJECT Boston University College of Engineering, Dept. of Biomedical Engineering Boston, MA Research Assistant September 2012- Present

Creating a single universal bimolecular sensor for in vitro diagnostic of nucleic acids in living cells by combining highly specialized components to address the challenges of RNA detection

Designing and implementing the project protocol to attain presentable and accurate scientific data to present in full project report to advisors and professors

Presenting completed project at Senior Design Project Conference in May 2013

PROFESSIONAL EXPERIENCE Amgen Inc., Quality Compliance West Greenwich, RI Undergraduate Intern June 2012- August 2012

Created and implemented a sustainable intranet Site Wide Inspection Readiness Program with a repository for all functional areas in support of GMP inspection readiness at the site

Participated in the inspection management process of a Third Party Audit by a major Japanese pharmaceutical company by working with cross functional areas in pre-audit preparation of SOPs and CAPAs

Developed a document detailing GMP Regulatory Inspection History to be presented during regulatory inspections and in support of submissions to emerging markets

Boston University School of Medicine, Vascular Biology Unit Boston, MA Research Assistant September 2011- January 2012

Mice genotyping of potential first mammalian model for age-dependent Parkinson’s disease with the use of PCR techniques and gel electrophoresis

AVEO Oncology, Cancer Biology Group Cambridge, MA Summer Intern Associate May 2011- August 2011

Research & development hands-on laboratory experience generating in vivo mouse cancer models used to identify therapeutic targets and analyzed efficacy of therapeutic treatment by manipulating gene expression in mice using engineered DNA constructs from known human and animal genes to generate transgenic mice from embryonic stem cell manipulation

Beth Israel Medical Center; Dept. of Obstetrics & Gynecology, Harvard Medical School Boston, MA Research Assistant and Summer Research Intern January 2010- May 2011

Evaluated the effect of different dosages of Cisplatin on the damage of ovaries using mice and rat models

Brigham Women’s Hospital; Dept. of Anesthesiology, Perioperative & Pain Medicine, HMS Boston, MA Summer Research Intern June 2008- August 2008

Study Promotion of Wound Closure of Human Airway Epithelial Cells and Planarians in the Presence of Lipid Mediators Resolvin E1 and Resolvin D1

Acknowledgement for assistance in initial planaria experiments in published paper “Serhan CN, Dalli J, Karamnov S, Choi A, Park CK, Xu ZZ, Ji RR, Zhu M, Petasis NA. “Macrophage Proresolving Mediator Maresin 1 Stimulates Tissue Regeneration and Controls Pain.” The FASEB Journal. 2012 Jan 17.”

SKILLS Computer: MATLAB, CAD, LabVIEW, SigmaPlot, SolidWorks, Microsoft Office, Microsoft SharePoint, Adobe Professional Lab: Western Blot, ELISA, cell culture, microscopy, mice handling, dissection, tissue collection, cardiac puncture, blastocysts

flushing and collection, survival mouse surgery, mice colony maintenance Languages: Mandarin Chinese (Proficient), Spanish (Conversational), American Sign Language (Basic)

HONORS & ACTIVITIES Siemens Scholar and Semifinalist for Siemens Competition: Math, Science, and Technology 2008-2009

Title: Novel Lipid Mediators Resolvin E1 & D1 Promote Wound Closure of Human Airway Epithelial Cells & Planarians Engineers Without Borders September 2009- Present

Secretary (10-11) and Webmaster (09-10) of Boston University Chapter Alpha Delta Pi Sorority at Boston University’s Rho Chapter January 2011- Present Dean’s Host for the College of Engineering January 2010- Present

Iris Kao

Andreas J. Kapfhammer Email: dreask@bu.edu Phone: 914-844-1272

School Address: 452 Park Drive #5, Boston, MA 02215 Permanent Address: 915 Edgewood Ave, Pelham, NY 10803

Objective: An entry level position in the field of Medical Devices and implants, with emphasis on development and design.

______________________________________________________________________________

Education: Boston University College of Engineering, Boston, MA September 2009-May 2013 Bachelor of Science, Biomedical Engineering Major Mechanical Engineer Minor Relevant Coursework: Heat transfer, Introduction to Solid Biomechanics, Material Science, Mechanics, Fundamentals of Fluid Mechanics, Fundamentals of Biomaterials, and Human Physiology

______________________________________________________________________________

Projects:

Senior Project: The Design and Testing of a New Nebulizer Fall 2012-Spring 2013 Currently working on researching and developing methods for improving current market nebulizers. I developed the LabView code currently being used for opening and timing of the medicine release. Biomedical Measurements II: The Effect of Caffeine on Ocular-motor function Spring 2012 Designed apparatus required for the experiment and the procedure to obtain the data from the EOG. Took the data from the experiment and transformed it using a Fourier transform in Matlab to analyze the frequency domain.

______________________________________________________________________________

Work Experience: Teacher for American Goju Karate Association, Pelham, NY 2004-current Responsibilities included teaching karate to people of all ages, creating lesson plans, organizing, opening

and closing classes, and teaching students’ self-defense.

______________________________________________________________________________

Skills:

Software Applications: Matlab, LabView, SigmaPlot, Microsoft office Familiar with Java, Python, and Solid Works Personal: Excels at working in groups, and can work alone as well Conversational in German and Spanish

Aimal H. Khankhel kaimal10@gmail.com • 75 Lupine Road • Lowell, MA 01850 • (978) 944-3383

EDUCATION

Boston University, College of Engineering Boston, Massachusetts

Bachelors of Science, Biomedical Engineering May 2013(anticipated)

RELEVANT COURSEWORK

Principles of Biomaterials, Solid Biomechanics, Mechanics of Materials, Fluid Mechanics, Thermodynamics, Biotransport,

Cell Biology, Systems Physiology, Biomedical Measurements, Microscopy, Signals and Systems, Control Systems,

Systems Biology of Human Disease.

EXPERIENCE

Senior Project: Pore Cast Scaffold for Vascular Tissue Engineering, Schepen’s Eye Research Institute, Boston, MA

September 2012-Present

Project goal is to design and construct a thin porous nonthrombogenic scaffold for use in vascular grafts by

implementing a polymer-casting technique:

o Determine desired scaffold porosity by modeling native vasculature in COMSOL.

o Design pore dimensions for scaffold to promote cell alignment.

o Create photomask template using Layout Editor.

o Construct master wafer using photolithography/microfabrication techniques.

o Measure mechanical properties of scaffold.

o Culture cells on scaffold and perform transmigration assays using H&E staining.

o Visualize cell alignment via Immunohistochemistry.

Undergraduate Researcher, The Tien Group, Boston University, Boston, MA

August 2011-Present

Researched quantitative physiology of engineered tissue.

Worked on a project highlighting the importance of drainage systems in vascularized microfluidic scaffolds.

o Constructed microfluidic devices using soft lithography techniques.

o Helped create microvessels in fibrin hydrogels with orthoganol drainage channels.

Investigated revascularization techniques of decellularized organ scaffolds.

o Decellularized tissue scaffolds via perfusion methods to view organ vascular network.

o Modelled revascularization by creating capillary-sized microvessels in collagen hydrogels and seeding

with endothelial cells.

Studied the effects of stiffening hydrogels on vascular stability.

o Constructed microvessels in collagen hydrogels and treated them with crosslinking agents.

o Seeded and observed endothelial cell behavior over time.

Research Assistant, Passaglia Visual Information Processing Lab, Boston University, Boston, MA

October 2010 – August 2011

Researched visual information processing, transmission, and computational models of visual coding.

Conducted research for the development of a visual hearing aid using spectrograms from Fourier transforms of

auditory signals.

Responsible for the programming and testing of a MATLAB code.

SKILLS

Cell Culture, Tissue Culture, Fluorescence, Soft Lithography, Photolithography/Microfabrication, MS Office, MATLAB,

SigmaPlot, SolidWorks, Labview

PUBLICATIONS

3. Chan K.L.S., Khankhel A.H., Thompson R., Wong K.H.K., Truslow J.G., Coisman B., Crosslinking of Collagen

Scaffolds Promotes Vascular Stability. In preparation to be submitted to J. Biomed. Mater. Res. A

2. Wong, K.H.K., Truslow, J.G., Khankhel A.H., & Tien, J. Biophysical mechanisms that govern the vascularization of

microfluidic scaffolds. in Vascularization: Regenerative Medicine and Tissue Engineering (ed. Brey, E.M.), in press

(CRC Press, Boca Raton, FL).

1. Wong K.H.K., Truslow J.G., Khankhel A.H., Chan K.L.S., & Tien J. Artificial Lymphatic Drainage Systems for

Vascularized Microfluidic Scaffolds. J. Biomed. Mater. Res. A, in press.

CONFERENCES AND PRESENTATIONS

“Revascularization of Decellularized Scaffolds” Undergraduate Research Opportunities Program Symposium (Boston,

MA; 2012).

“Pore-cast Scaffold for Vascular Tissue Engineering” Northeast Bioengineering Conference (Syracuse, NY; 2013).

Daniel S. Kim kimsomin@bu.edu

School Address

33 Harry Agganis Way, Box 9650

Boston, MA 02215

917.291.7247

Permanent Address

82 Shale Street

Staten Island, NY 10314

718.983.5028

EDUCATION

Boston University College of Engineering, Boston MA

Bachelor of Science in Biomedical Engineering, Expected: May 2013

Concentration in Nanotechnology, Expected: May 2013

Relevant Coursework: Cellular/Molecular Biology, Signals and Systems, Control Systems, Thermodynamics, Systems Bio

Disease, Solid/Continuum Biomechanics, Organic Chemistry I, Electric Circuit Theory, Intro to

Probability/Statistics, MATLAB, Intro to Software Engineering, Nanotechnology and Nanomaterials,

Nanomedicine, Nano-Scale Processes in Living Systems

TECHNICAL SKILLS

CORE RESEARCH: Scanning Electron Microscopy, Photolithography, Cell culture, PCR, Western

blotting, Column chromatography, Microscopy, Ultrasound imaging

SOFTWARE: MATLAB, C, C++, C#, Objective C, Java, ImageJ, ARTCAM, SigmaPlot, WEKA,

GenePattern

PROFESSIONAL EXPERIENCE

BIOMEDICAL ENGINEERING TEACHING LAB, Boston University Sept 12 - Present

BME Teaching Laboratories Manager: Jesse Connell

Teaching Assistant

Assist in laboratory equipment maintenance and troubleshooting software/hardware failures.

Collaborate with teaching faculty in teaching core concepts for laboratory exercises specifically

in Signals and Systems/Control Systems theory.

HORMONE ASSAY CORE LABORATORY, Boston Medical Center Jun 10 – Aug 10

Principal Investigator (PI): Dr. Jagadish Ulloor, Ph.D.

Research Assistant

Role of Deoxy HydroTestosterone (DHT) and other steroid hormones (i.e. LH, FSH, and DHT)

in Cardiovascular disease, specifically in the development of Myocardial Infarction and gender

differences.

ENGINEERING PROJECTS

Design/Fabrication of Semiconductor Nanosensor for Cancer Diagnosis and Monitoring Sept 12 - Present

Design and fabrication of nanosensor with high sensitivity for cancer detection in cases with low

concentration of biomarkers (i.e. melanoma and early stages of other cancers). Sensor is to be fabricated

using photolithography and SEM for high accuracy. Sensor testing will be performed against melanoma

and other protein biomarkers.

Design/Manufacture of Electronic Stethoscope Nov 11 – Dec 11

Designed and manufactured an electronic stethoscope for cardiac auscultation. Stethoscope measured

intensity of auscultation, calculated heart rate, analyzed the Mayer Waveform for possible heart

murmurs and determined the condition of the heart using MATLAB programming.

AWARDS

Boston University College of Engineering Dean’s List Fall 2010

CAS Honors Program Fall 2009 – Spring 2010

MATTHEW S. KRAMER

443 Lanipuao St Honolulu, HI 96825 808-392-2003 mskramer@bu.edu  Objective To gain insight and experience in biomedical engineering, specifically in prosthesis and rehabilitation.  Education Boston University College of Engineering                    Boston, MA Bachelor of Science in Biomedical Engineering                              May 2013 GPA: 3.61  Technical University of Dresden                                Dresden, Germany Boston University Study Abroad Program              Feb—July 2011  Honors/Awards Dean’s List 6 semesters  AEMB National Biomedical Engineering Honor Society  Relevant coursework Signals and Systems in Biomedical Engineering, Control Systems in Biomedical Engineering, Fundamentals of Nanomaterials and Nanotechnology, Thermodynamics, Fundamentals of Fluid Mechanics, Computational Neural Models, Computational Movement Models    Projects Truss Class Project 

• Tested and analyzed construction material (soda straws) for member’s to find buckling strength. • Designed simple plane truss to specified dimensions, minimum load, and cost. • Tested constructed truss to failure and compared theoretical max load to that tested. 

 Signal Processing Class Project 

• Wrote a MATLAB script to identify an ambulance siren. • Tested program with an ambulance siren recorded with varying degrees of ambient noise.  

 Leadership Boston University Hawaii Cultural Association, Vice President, Boston MA, Aug 2011—present 

• Coordinate the technical production of annual events • Organize previous club document and create event handbooks 

NALU Studies, Teaching Assistant, Honolulu HI, Jun—Aug 2010 • Assisted in administering intensive science and laboratory course to at risk youth. • Oversaw lab activities and field work • Mentored students in their course work 

 Skills Lab tools: oscilloscope, centrifuge, spectrometer, EEG cap, pressure transducer, pneumotachometer, Computer: MATLAB, LabView, LabScribe 2, SigmaPlot, WinTruss, MS Word, MS Excel 

Corey Kronman 6 Beals St. Apt. 3, Brookline MA, 02446 Phone: (631) 987-0128 E-Mail: ckronman@bu.edu

Education

Boston University, Boston MA Class of 2013 Major: Biomedical Engineering Track: Premedical Current Overall GPA: 3.18

Relevant Courses: General Chemistry I & II Physics I & II Multivariate Calculus Differential Equations Principles of Molecular Cell Biology & Biotechnology Systems Physiology Thermodynamics and Statistical Mechanics Biomedical Measurements I & II Electric Circuit Theory Signals and Systems in Biomedical Engineering Control Systems in Biomedical Engineering Organic Chemistry I & II Biotransport Fundamentals of Biomaterials Applications of Tissue Engineering Neuroengineering Product Design and Innovations

Activities: BMES (2010 – Present), Boston University Freerunning and Parkour (2011 – Present |Founder), Boston University Cheerleading (2011 – Present | Co-Captain 2012-2013), Boston University Brazilian Association (2009 – Present | Secretary 2010), Boston University Outing Club (2009 – Present)

Eastport South Manor Jr./Sr. High School, Manorville NY Class of 2009 GPA: 97.3

Activities: Club Interact (2004 – 2009), JV Wrestling (2005 – 2007), Varsity Wrestling (2007 – 2009), National Honors Society (2007 – 2009), National French Honors Society (2007 – 2009)

Professional Experience

Everwood Day Camp Summer 2012 High & Low Ropes Course Instructor Responsibilities include setting up challenge courses; facilitating groups of 5 to 20 in building trust, communication, and teamwork; as well as keeping participants safe on high and low rope challenges.

Imperial Bag (Formerly Center Moriches Paper Co. Inc.) Summers 2011, 2010, 2008 Warehouse Staff Responsibilities included operating a forklift, receiving shipments, stocking shipments, pulling orders to be sent, loading and organizing outgoing trucks, handling time sensitive customer orders.

Southampton Bathing Corporation Summer 2009 Lifeguard Responsible for the safety of children and adults alike around a water environment

Additional Skills Languages: Portuguese Fluency. Spanish & Hebrew Conversant. German, French & ASL Basics Computer: Mac, Windows, Linux. MATLAB, Arduino, Microsoft Office, ImageJ, PSpice General: Soldering, Tumbling & Acrobatics

Soon Bin Kwon

138 Essex St, South Hamilton, MA 617.834.6912 | soonbin@bu.edu | Canadian Citizen

EDUCATION Boston University School of Engineering; Boston, MA Expected: Aug, 2013 Bachelor of Science in Biomedical Engineering

RELEVANT COURSEWORK

Senior Innovation: FDA rules regarding medical devices

Senior Project: Designing MRI phantom that would mimic human liver cell Engineering Economics, Signals and System, Biomedical Measurement, Introduction to Logic Design, Mechanics I, Solid Mechanics, Organic Chemistry, physiology, Thermodynamics and Statistical Mechanics, Introduction to Medical Imaging Processing, Principle and Application of tissue engineering, Principle of molecular cell biology and biotechnology, Control system in biomedical engineering, Electric Circuit Theory, Electronics.

Project experience

Proposal for Catheter Balloon:

• Full proposal written as if we are the first inventor of it • In a format that could be handed in to FDA • Included all regulation that it needs to pass

Truss Design Project:

• Designed, constructed, and tested a simple truss Developed designs and made recommendations to improve the technology and product design

• Predicted and tested the breaking point of the design.

.

Got Universal Lab Training

TECHNICAL SKILLS Matlab, Mathcad, Verilog, Spice(OrCAD)

 

REBECCA M. LACROIX 20 Sunberg Rd., Spencer, MA 01562 rlacroix@bu.edu (508) 612-0795

EDUCATION Boston University College of Engineering Boston, MA

Bachelor of Science in Biomedical Engineering, expected in May 2013

GPA: 3.5/4.0 (Dean’s List: 5 of 7 Semesters)

Study abroad program at Tel Aviv University (Spring 2011) Tel Aviv, Israel

Relevant Coursework: Biomaterials, Tissue Engineering, Biotransport, Computational Vision, Continuum Mechanics,

Fluid Mechanics, Material Science, Control Systems, Signals and Systems, Product Design, Human Physiology

PUBLICATIONS Cheung, M.C., LaCroix, R., McKenna, B.K., Liu, L., Winkelman, J., Ehrlich, D.J. Intracellular protein and nucleic acid

mass measured in eight cell types using deep ultraviolet mass mapping. Cytometry Part A (in press).

Ho, N., Fan, A., LaCroix, R.M., Wong, M.D., Klapperich, C.M., Cabodi, M., Sample concentration and purification for

point-of-care diagnostics, Analytical Chemistry (in preparation).

POSTER PRESENTATIONS LaCroix, R., Wong, M.D., Ho, N.T., Connor, J., Mamaeva, N., Klapperich, C.M., Cabodi, M. Optimization of Virus

Sample Enrichment in a Microfluidic Chip, Biomedical Engineering Society Annual Meeting, Atlanta, GA, 2012.

DESIGN PROJECTS

Design and Characterization of Integrated Microfluidic System for Sample Concentration and Extraction:

Fabrication of a viral RNA extraction column for human plasma samples. Integration of extraction column into a closed

microfluidic system that concentrates plasma, lyses virions, and extracts viral RNA for detection. Optimization of system

for HIV sample preparation in resource-limited settings. (Senior Project 2012-2013)

Speech Recognition Program: Designed a single-user speech recognition program in MATLAB using frequency

analysis. Compares a spoken word to words in a database and outputs the closest match based on frequency. (Fall 2011)

EXPERIENCE Research Assistant January 2012-Present

The BU Klapperich Laboratory for Diagnostics and Global Healthcare Technologies Boston, MA

• Fabrication and optimization of a microfluidic device for virus sample concentration and purification.

• Analysis of device performance using RNA extraction (Qiagen) and qRT-PCR.

Research Assistant September 2011-May 2012

Cell Photometrics Laboratory at Boston University Boston, MA

• Used deep UV microscopy to create a catalog of the nucleic acid and protein masses of different cell types.

• Used ImageJ and MATLAB to perform light adjustments, align images, and make cell density calculations.

Research Assistant September-December 2010

Neuromuscular Research Center at Boston University Boston, MA

• Used MATLAB to generate plots relating the activity of individual motor units during muscle contraction.

Grader for Fluid Mechanics January-May 2013

Boston University College of Engineering Boston, MA

• Chosen as a grader after excelling in the course.

SKILLS

RNA extraction, qRT-PCR, Pierce BCA assay, cell microscopy, MATLAB, ECG signal acquisition, ImageJ, LabVIEW

ACTIVITIES AND AWARDS

Tau Beta Pi, Engineering Honor Society, Massachusetts Eta Chapter December 2012-Present

Alpha Eta Mu Beta (AEMB), National Biomedical Engineering Honor Society October 2012-Present

Treasurer, BU Global Awareness Project April 2012-Present

Biomedical Engineering Society (BU chapter) September 2011-Present

College of Engineering Summer Term Alumni Research Scholars (STARS) Award Summer 2012

Recipient of the Steven P. Evans Memorial Scholarship Award (BU) Spring 2011

Joonnyong  Lee     Boston  University  College  of  Engineering  Email:  jpailee@bu.edu                       Phone:  805-­‐264-­‐2003    Status (as of 17 April 2013): 4th year undergraduate dual degree program in Biomedical Engineering and in Mathematics(Pure and Applied) Laboratory Experience: -2008~2009: IB extended essay on the reaction between sodium bicarbonate and tartaric acid -June 2010~August 2010: International Vaccine Institute in Seoul, Korea

Hands-on experience with multiple research techniques including ELISA, cell culturing, cloning, RTPCR, PCR, gel electrophoresis, cell extraction from bone marrow, LAL test, and plaque assay.

-Spring 2011: BE209(Cell Biology) Laboratory classes -Summer 2011: CAS BI 315(Systems Physiology) Laboratory classes -Fall 2011: BE491(Biomedical Measurements I) Laboratory classes & final project,

BE401 computer labs(Signals and Systems), EC481 Laboratory classes(Intro. to Nanotechnology)

-Spring 2012: BE492(Biomedical Measurements II) Laboratory classes -June 2012~July 2012: Laboratory Volunteer at the Smolina Lab (BU BME) -September 2012~(current): Senior Design Project at Khademhosseini Lab (Harvard Medical School), designing and developing a novel linear stretch bioreactor with gel-grip mechanism for cardiac tissue engineering. Relevant Work Experience: -IB Tutor 2008-2009 in mathematics, chemistry, and biology -Internship at the International Vaccine Institute(IVI), Seoul, Korea, summer 2010 -BE491 project: EOG-based neural interphase for typing mechanism -MATLAB code for revised simplex method for linear optimization problems Relevant Program Experiences/Skills:

1) MATLAB – basic programming, modeling, simulations, and calculations 2) Excel – basic graphing and data organization 3) ImageJ – basic image processing 4) SigmaPlot – data plotting 5) Basic molecular biology techniques – RCA, PCR, ELISA, cloning, etc… 6) Optical Microscopy- Bright-field and Graded-field 7) ECG/EOG measurements - Signal conditioning and analysis 8) Programmable NC mill

List  of  Honors:  Deans  List  Fall  2011  (BU  College  of  Engineering)  Deans  List  Spring  2012  (BU  College  of  Engineering)  Deans  List  Fall  2012  (BU  College  of  Engineering)    List  of  Scholarships:  Engineering  Scholars  Award  (BU  College  of  Engineering)  2009~2010,  2012~2013  

Christopher J. Lim clim14@hotmail.com

(732) 598-4313 School Address Home Address 1079 Commonwealth Ave, Apt. 321 2131 Baileys Corner Road Boston, MA 02215 Wall, NJ 07719

Education

Boston University College of Engineering, Boston, MA Bachelor of Science, Biomedical Engineering May 2013 Graduate Engineering Dean’s List: Fall 2009

Experience

Corporate Solutions Co-op Engineer Summer 2012 Enterasys Secure Networks, Andover, MA

Provide customers with networking and security solutions Responsible for programming and showcasing new BYOD networking protocols

Information Technology Intern Summer 2011 X Plus One Solutions Inc., New York, NY

Support computer systems to improve communication Improve functionality and profitability for computer systems

BU Engineering Dean’s Host and Student Advisor Fall 2010-Present BU College of Engineering, Boston, MA

Representative at formal events such as Open Houses and Parents’ Weekends Freshmen Class of 2016 mentor and student teacher for Intro to Engineering

Achievements

Senior Engineering Project: Design and Test a Unique Controlled Nebulizer Design and build a nebulizer that operates an independent drug delivery system Integrate MATLAB and LabVIEW computer programs for data acquisition and analysis

Polygraph Using Biomedical Instruments

Constructed a polygraph lie detector system via real-time EKG, EOG, and GSR readings collected from a LabVIEW logic program

Activities & Interests Biomedical Engineering Society (BMES), Boston University Chapter, Member since 2009 2010 Boston Half Marathon Participant Black Belt in Karate & member of BU Taekwondo Club Intramural Soccer Team Captain, Spring Championship 2012 Boston University Community Service FYSOP Program Boston University Order of the Engineer

Vincent Lin 826 Beacon Street, Boston, MA, 02215

(917) 907-3869 | vlin91@gmail.com | www.vincent-lin.com

EDUCATION Boston University College of Engineering – Boston, MA Candidate for Bachelor of Science in Biomedical Engineering, May 2013 • 3.14/4.0 Cumulative GPA National University of Singapore – Singapore Study Abroad Exchange Program, Jan – May 2012 WORK EXPERIENCE Lead Mobile Developer March 2013 – Present Education First, Mobile Strategy Department Cambridge, MA • Work in a team of 4 as company’s first mobile technology team • Develop Android and iPhone applications to meet technology-based solutions in breaking down barriers of culture, geography, and language Volunteer June 2012 – November 2012 Spaulding Rehabilitation Hospital, Assistive Technology Department Cambridge, MA • Collaborated with occupational therapists by problem solving and designing how to fit various assistive technology devices to the specific needs of incoming patients • Collaborated with physical therapists by assembling manual or powered wheelchairs for incoming patients Undergraduate Design Researcher January 2011 – May 2013 Boston University Auditory Neuroscience Laboratory Boston, MA

• Collaborated with research engineer on research of a project in analyzing auditory brainstem responses of EEG signals at threshold level, earning 2012 Summer Term Alumni Research Funding

• Research project was presented at the 2012 Hong Kong Acoustics Conference • Performed signal processing and pattern recognition analysis on EEG data • Designed psychoacoustic experiments and digital circuits using Matlab, the Tucker-Davis Technologies RPvdsEx hardware, and the Biosemi EEG system Co-Founder/iOS Developer September 2011 – June 2012 Mind Vacation Inc. Boston, MA • Developed mobile iOS applications using Objective C Programming, including building a complete iPhone application in 14 hours with a team of 3 • Application was a finalist at the 2011 Vampire Hackathon hosted by the Tap Lab • Designed graphics and maintained company website using Adobe platform products LEADERSHIP Co-Founder/Vice President September 2011 - Present Speeches for Students @ Boston University Boston, MA • Build a web video archive of informational interviews with Boston University Alumni to spread career knowledge and provide BU students with unique career perspectives TECHNICAL SKILLS • Android, iPhone, Matlab, Java, Objective C, C++, HTML, CSS, EEG, Digital circuit design, Signal processing, E-Prime, LabView, AutoCAD, SolidWorks, Adobe (Photoshop, Illustrator, Lightroom, Dreamweaver)

Lena Liu 19 Aberdeen Street Apt 1, Boston, MA 02215 • (909) 767-9028• lenais@bu.edu • www.linkedin.com/in/lenaliu

Objective Expand my current knowledge and experience in biological research and engineering at a full time position within a reputable company.

Education Boston University College of Engineering Boston, MA Bachelor of Science, Biomedical Engineering May 2013 Relevant Course Work: Mechanics of Biomaterials, Molecular Cell Biology, Systems Physiology, Mechanics of Materials, Signals and Systems, Control Systems, Simulation of Physical Processes, Introduction to Engineering Computation, Fluid Mechanics, Microelectronic Device Manufacturing, Tissue Engineering and Drug Delivery

Research Experience Klapperich Lab, College of Engineering, Boston University Boston, MA Lab Assistant Dec. 2010-Present Nanomedicine Thyroid Cancer Detection Project •Prepared and passaged thyroid cancer cell cultures •Determined lowest limit of detection of total protein concentration in whole cell lysate for BCA protein assay •Identified specific proteins in cancer cells using western blots •Developed and optimized a protocol for protein extraction and purification

Point-of-Care Viral Concentration Device for Rapid Molecular Diagnostics of Influenza •Developed microfluidic chips with a molding technique and three-dimensional layering •Fabricated silica filled microfluidic chips by photopolymerization •Extracted viral RNA from live patient samples with a Qiagen kit •Tested an extraction method using syringe pump pressurized microfluidic chips

Microfluidic Bacterial Concentrator for Surface Enhanced Raman Spectroscopy •Concentrated bacteria using a lab-on-a-chip method

Allvivo Vascular Inc. Lake Forest, California Summer Intern Jun 2012-Aug 2012 Antimicrobial Catheter Coating Development •Identified the presence of proteins by performing an ELISA on antimicrobial coated polymer samples •Designed and tested coating formulations for catheters •Performed bacteria assays to determine the efficacy of the antimicrobial coating •Developed a protocol for preparing and molding catheter polymer samples Senior Project Microfluidic Chip for Thyroid Cancer Diagnosis Sept 2012-Present •Developed and optimized a protein extraction and purification method for whole cell lysates •Optimized an indirect ELISA protocol for a thyroid cancer protein biomarker •Designed and fabricated an modified on-chip immunoassay

Skills Laboratory Techniques: Western Blot, ELISA, ELISPOT, BCA Protein Assay, Protein Concentration, Whole cell protein extraction, Polymerase chain reaction (PCR), Fast prototyping lab-on-a-chip fabrication, RNA Extraction, Bacteria Culture, Cell Culture, Gel electrophoresis, Qiagen RNA Kit, Animal dissection, Experimental design, Titration, Laboratory Tools: Spectrometer, Syringe pump, Hydraulic bench top manual press, NanoDrop, PCR Computer Skills: Proficient in: Matlab, Sigma Plot, Msicrosoft Office Familiar With: AutoCAD, Mathematica, MathCad, WinTruss, LabScribe, LabView, Solidworks, COMSOL, C++

Other COMSOL Simulation Project: Microfluidics, PCR Lab-on-a-Chip •Developed a microfluidic mixer in COMSOL to visualize different mixed solutions and samples for PCR L. Liu, S. Huang, S. Sharma, J. Rosen, C. Klapperich A Microfluidic Device for Protein Biomarker Based Diagnosis of Thyroid Cancer [Poster Presentation Delivered at the Biomedical Engineering Society Conference] J. Zhang, M. Mahalanabis, L. Liu, J. Chang, N, Pollock, C. Klapperich A Disposable Microfluidic Virus Concentration Device Based on Evaporation and Interfacial Tension [Published 28 Feb 2013 in Diagnostics]

Local: Box 0302

726 Commonwealth Avenue

Boston, MA 02215

JO-ANN LOH (646) 684-0134 jloh28@bu.edu

Permanent:

87-52, 52nd Avenue

Elmhurst, NY 11373

OBJECTIVE: Highly motivated engineer seeking an entry-level position in medical device product development.

EDUCATION

Boston University College of Engineering, Boston, MA

Bachelor of Science, Biomedical Engineering, May 2013

Minor in Biology, Concentration in Technology Innovation

Dean’s List, LSAMP NSF Grant

GPA: 3.21/4.00

Major GPA: 3.51/4.00

Technische Universität Dresden, Dresden, Germany: Study Abroad, Spring 201l

Relevant Coursework:

Product Design & Innovation

Product Development

Business of Tech. Innovations

Device & Diagnostic Design

Strategies for Bringing Tech. to Mkt.

Signals & Systems

Control Systems

Thermodynamics

Nanomaterials & Nanotech

Electric Circuit Theory

Cell Bio & Biotech

Medical Imaging

Biotransport

Systems Physiology

Next Generation Sequencing

PROJECTS

Senior Design Project: Lab for Engineering Education & Development (LEED)

“Developing a microfluidic diagnostic for congenital syphilis in resource-limited settings”

Sept 2012 – May 2013

Designed on AutoCAD a microfluidic diagnostic to detect TpN antigens in blood suitable for use in resource-limited settings

Increased signal-to-noise ratio with a microchromatograph separation column filter before application of a sandwich ELISA

Endoscopic Excision and Capturing Device Design Jan 2013 – May 2013

Designed on SolidWorks and prototyped an endoscopic device to remove and capture polyps with a team of three students

Optimized for biocompatibility, material selection, design for manufacturing, failure analysis, and regulatory requirements

Commercialization of an Antiviral Jan 2013 – May 2013

Collaborated with the Conner Lab and industry mentors to analyze commercialization pathways for a broad spectrum antiviral

VeriFLEX™ Cardiovascular Stent System Proposal Sept 2012 – Dec 2012

Acted as a Boston Scientific R&D team designing the VeriFLEX™ Cardiovascular Stent System

Followed product development protocol dictated by CFR-21 regulations and FDA Medical Device guidelines

Microphone-based Respiratory Monitoring System Sept 2011 – Dec 2011

Designed and constructed a microphone-based respiratory system with a team of three students

Used digital and analog signal processing techniques to remove noise and aid signal analysis to calculate breathing rate/min

EXPERIENCE Research Assistant at Rensselaer Polytechnic Institute, Lab for Tissue Eng. & Morphogenesis, Troy, NY May 2012 – Aug 2012

Undergraduate Research Assistant, Participant of the Louis Stokes Alliances for Minority Participation Program (funded by NSF)

“ Effect of altered cell membrane electropotential on cell chirality due to ion inhibitor pharmaceuticals”

Designed single and multicellular patterns on AutoCAD and LayoutEditor to be etched on silicon wafers

Employed micro-contact patterning techniques to form multicellular shapes on gold-plated slides for ion inhibitor treatment

Determined cell chirality of patterns with MATLAB and ImageJ

Research Assistant at BU Stepp Lab for Sensorimotor Rehabilitation Eng., Boston, MA Feb 2012 – May 2012

Undergraduate Research Assistant

Collaborated with acoustics team on a project studying the relationship between acoustic parameters and speech physiology

Examined Praat spectrograms to develop objective speech measurements to aid clinical diagnosis of Parkinson patients

SKILLS

Computer: Microsoft Office, MATLAB, AutoCAD, SigmaPlot, Praat, LabScribe, LabView, ImageJ, LayoutEditor, MathCAD

Laboratory: micro-contact printing for cell-patterning, cell culture and passaging, light and fluorescence microscopy, gram staining,

spectrophotometry, PCR, ELISA, gel electrophoresis, ultrasounds, soft lithography, autoclave

LEADERSHIP/ACTIVITIES

Engineering Student Government/ENGGOV (Class Secretary)

Technology Innovations Scholars Program (FIRST® Mentor)

BU College of Engineering Dean’s Host

Global Awareness Project/GAP (Founding Secretary)

EK100 Engineering Student Advisor

PROFESSIONAL ASSOCIATIONS

Society of Women Engineers/SWE (Senior Class Representative) Biomedical Engineering Society/BMES

Sean Manton

4335 E 14th Ave.

Denver, CO 80220 303-718-4495

sxmanton@bu.edu

Objective

A job or internship in neuroscience, especially with relation to music, meditation or education enhancement, or working on sustainable energy.

Education

Boston University, College of Engineering, Boston, MA

� Bachelor of Science in Biomedical Engineering, May 2013

� GPA: 3.72/4.00, Magna Cum Laude

� Music minor in the College of Fine Arts

� Relevant coursework: Signals and Systems, Digital Signal Processing, Intro to Neuroengineering, Biological and Environmental Acoustics, Music Theory, Electronic Music Composition, Auditory Neuroscience, Software Engineering

Work Experience

Research Assistant

Sept.-Dec. 2010, June-Aug. 2012, BU Auditory Neuroscience Lab, Boston, MA

� Routine EEG electrode maintenance

� GUI Design in MATLAB

� EEG experiment design and data analysis

Research Assistant

June-Aug. 2010, UCHSC Neurology and Immunology, Aurora, CO

� Multiple sclerosis research using phage library screening

� Utilized techniques including cell culture titering, ELISA, PCR, and Western Blotting

Other Skills

� Computer Skills: MATLAB, Python, Max/MSP, HTML, C++

� Languages: Mandarin Chinese

Activities and Honors

� BU Alexander Graham Bell Scholar

� Tau Beta Pi, National Engineering Honor Society, member since 2012

� Alpha Eta Mu Beta, Biomedical Engineering Honor Society, member since 2012

� BU In Achord, co-ed a cappella group, member since 2009

References

References are available on request.

JALE NICOLE MANZO

Address: 33 Harry Agganis Way

Boston, MA, 02215

Tel: 973-557-8827

Email: jmanzo@bu.edu

EDUCATION

•Boston University, September 2009- 2013present. B.S., Biomedical Engineering, College of Engineering.

WORK HISTORY

•Binaural Hearing Lab. Boston University. Research Assistant. January 2012 – May 2012

•Waitress, Mumbar. Karaburun Turkey. July 2011

•Ingalls Engineering Resource Center, Boston University. Monitor. September 2011- May 2012

MEDICAL/SCIENCE EXPERIENCE

•Saint Clare’s Hospital, New Jersey. Volunteer. May 2011 – August 2011; May 2012 – August 2012.

•Northern Westchester Hospital, New York. Volunteer. May 2011- August 2011.

•American Society of Neuroradiology, Annual Meeting Seattle. Guest. July 2011.

•Premedical Society, Boston University. Member. September 2009- present.

•Chemistry Day, Boston University. Volunteer. April 2011.

RESEARCH EXPERIENCE

Institution: Porter Lab, Biomedical Engineering, Boston University. Boston, MA. September 2012-Present

Principle investigator: Tyrone Porter Ph.D.

Research assistant: David Conegliano, Jale Manzo, Emily Polson

Developing a triple component targeted nanoparticle consisting of a hydrophobic polymeric core encapsulated with doxorubicin, a

fusogenic lipid monolayer, a hydrolysable coating at low pH environments, and a folic acid targeting component. This nanoparticle

will require a lower dosage and will be more specific than conventional chemotherapeutic drug delivery systems.

Institution: Massachusetts General Hospital. Boston, MA. January 2012-May 2012

Principle investigator: Rosemary Tambouret MD

Research assistant: Jale Manzo

Investigating effective procedures to screen patients with cervical cancer in remote areas with no electric supply. Analyzed different

methods of cell density separation and slide preparation. Research goal is to modify liquid based cervical cancer screening so it is low

cost and easily accessible to low resource countries enabling patients to get routine screens for cancer.

Institution: Binaural Hearing Lab, Biomedical Engineering, Boston University. Boston, MA. January 2012-May 2012

Principle investigator: H. Steven Colburn Ph.D.

Research assistant: Jale Manzo, Kristian Thomas

Researching how an individual hears in different acoustic settings by observing and processing the signal obtained from Knowles

Electronic Manikin for Acoustic Research (KEMAR).

Neural Perception of Acoustic Stimuli. November 2011-December 2011

Institution: Biomedical Measurements I BE491. Biomedical Engineering, Boston University. Boston, MA.

Supervisor: David C. Mountain Ph.D.

Researchers: Jale Manzo, Michael Francis, Fiona Raso, Krista Rochussen, Ashley Stein

Researched how well an individual can locate the provenance of a sound by observing an individual’s analysis and reaction to sound.

We aim to analyze whether an individual could determine the location of a source of sound with varying degrees of azimuth and

elevation in space with less error if they have a visual aid or if no visual aid is present.

SCIENTIFIC PRESENTATIONS

•Francis, M., Manzo, J., Rochussen, K., Raso, F., and Stein, A. "Neural Perception of Acoustic Stimuli." (December 2011).

•R. Tambouret and J. Manzo “Modified Manual Liquid Based Cervical Cytology for Low Resource Settings” (May 2012)

PROFESSIONAL ASSOCIATIONS AND PERSONAL ACTIVTIES

•Biomedical Engineering Society, Boston University.

•West Milford Township High School Color Guard. Instructor. July 2009 – present. West Milford, NJ.

•Boston University Outing Club, Boston University. Member. September 2009- present.

•INT League, New England: Competition Water Ski Slalom. Member. July 2009- present.

ADDITIONAL SKILLS

•Fluent in Turkish and advanced Turkish reading, and writing skills.

•Advanced Microsoft Office Word and Microsoft Excel skills.

KATHERINE A. MARCACCIO 20 Plowshare Court Mansfield, MA 02048

(774) 266-0740

kamarc125@gmail.com

Objective: Seeking a position in the Regulatory Affairs department, preferably in the pharmaceutical or biotechnology fields.

Education: Boston University, Boston, MA

Bachelor of Science, Biomedical Engineering

Anticipated Graduation: May 2013

GPA: 3.17/4.00

Academic Projects:

Design, construction and testing of truss model (Fall 2010)

Design and completion of laboratory testing to determine bovine blood decomposition characteristics (Fall 2011)

Medical device design and development project (Fall 2012)

Invention and patent write-up of telescoping heel (Fall 2012)

Design and construction of bench-top model for testing of proposed tensiometer design in esophageal atresia surgery

(Fall 2012, Spring 2013)

Professional Societies: Order of the Engineer

Honors: Dean’s List (Fall 2009, Spring 2011, Fall 2012), Boston University Engineering Scholar’s Program (Fall 2009,

Spring 2010)

Mansfield High School, Mansfield, MA

June 2009

Honors: National Honor Society, French National Honor Society, Latin National Honor Society, Bausch & Lomb Book

Award (2008)

Relevant Experience:

Regulatory Affairs Intern 4/2008-Present

Smith & Nephew, Inc. ASD Division Mansfield, MA

Execute projects to support new product registrations in worldwide markets including Japan, Canada, EU,

Pacific Rim, and South America.

Completion of new product registrations for Canadian and Japanese markets.

Organization of annual internal Design Dossier audit procedure and completion of annual internal Design

Dossier audits.

Documentation Control/Quality Assurance Intern 6/2007 – 4/2008

Zimmer Spine (formerly Endius, Inc) Plainville, MA

Review/process all technical documentation (SOPs, WIs, Forms, Drawings, DMRs, IFUs, Labels,

technique guides, etc.) through the Change Control System in accordance with FDA, EU and internal

requirements.

Compiled Document Control trending data for monthly Quality Meetings.

Additional Experience:

Office Assistant 9/2010-Present

Boston University, Office of Biomedical Engineering Boston, MA

Skills: Professional Skills: Working knowledge of applicable regulations to the Medical Device industry including: FDA’s Quality

Systems Regulation (QSR), International Standardization Organization (ISO), Medical Device Directive (MDD)

regulations.

Effectively interface with staff including Regulatory Affairs, Quality Assurance, Marketing, R&D and

Manufacturing.

Computer Skills: Working knowledge of Word, Excel, PowerPoint, Visio, Access, and MATLAB

Language Skills: Conversational in French

Peter McGuirk 54 Pratt St

Allston, MA 02134

(518) 598-6958/pmcguirk@bu.edu

OBJECTIVE

Improve the efficiency and effectiveness of the health care system

EDUCATION

Boston University - Senior in Biomedical Engineering, BS May 2013

GPA: 3.36

Coursework

Product Design

Signals and Systems

Cell Biology

Software Development

Systems Physiology

Control Systems

Thermodynamics

Circuit Theory

Differential Equations

PROFESSIONAL EXPERIENCE

Union Biometrica May-August 2012, Holliston, MA

Optimized system parameters on a prototype flow cytometer instrument for a demo to a potential buyer

Assembled parts for a top-of-the-line product to be sold to a German client

Modified sample cup mount so a wider range of samples could be passed through the instrument; mount is now

being machined to new dimensions based on findings

Zimmer New England May-August 2011, Albany, NY

Lowered inventory costs by identifying and returning unused medical equipment in storage

Observed hip and knee replacement surgeries

Sterilized medical equipment with autoclave so it could be safely disposed

SKILLS

Lab Skills

Instron Mechanical Testing

Micro CT Scanning

Flow Cytometry

Plasmid Transformation

Data Analysis

MATLAB

Labview

Sigmaplot

Microsoft Office

Other

C++

510k, PMA, IDE Documentation

AutoDesk Inventor

PROJECTS

Modeling Trabecular Bone Strength: Capstone Project September 2012-Present, BIDMC Orthopedics Boston, MA

Exploring new methods of modeling trabecular bone strength to better understand effects of osteoporosis and

arthritis on bone stiffness

Drafting MATLAB code to characterize trabecular bone matrix

Mechanical compression testing on whale vertebrae and aluminum foam samples using Instron machine

First semester work was presented at an ASME conference by PhD student working in lab

EOG Based Communication September-December 2011 Boston Univerisity

Designed and tested a communication system based on eye movements for paralysis patients

Drafted MATLAB code and developed a working prototype of the product

ADDITIONAL EXPERIENCE

Member of Boston University’s DREAM Program January 2010-Present, Boston, MA

Youth mentor; expose youth in Boston’s Roxbury neighborhood to options after high school

Raised $1500 for a trip to Maine and $1000 for a trip to a camping site in Vermont

Lynne Theresa Messina

3 Adams St. · Brookline, Massachusetts 02446· 617.462.5374· lynne.t.messina@gmail.com

OBJECTIVE To obtain a challenging position in an engineering or technical field

EDUCATION

Boston University, College of Engineering (Graduating May 2013) Biomedical Engineering

Relevant Coursework Thermodynamics Boston, MA Product Development & Design/ Device and Diagnostics Design Boston University

Molecular Cellular Biology/Human Physiology 2009 - present

Electric Circuit Theory Solid/Fluid Engineering Mechanics

Signals & Systems/Control Systems Engineering Economy

SENIOR DESIGN PROJECT

Dysphagia Research at Stepp Lab: Sensorimotor Rehabilitation Engineering Lab College of Health and Rehabilitation Sciences

ENGINEERING EXPERIENCE

St. Jude Medical Westford, MA

Quality Intern May - August 2012

- Performed root cause analysis in optical catheter failures and gave feedback to the rest of the team - Developed a trending analysis and presented results at weekly update meetings

- Worked in accordance to FDA regulations and medical device documentation

Concert Medical Norwell, MA

Engineering Intern April - August 2011 - Developed test procedures for different types of lubricious guidewires

- Recreated test equipment for examining torquewires spun at certain velocities to measure the uniformity of a 360° rotation

- Designed and built an automated process for coining the guidewires with computer interface and a stepper motor with a coining machine

ACTIVITIES

Sigma Alpha Lambda (Honor Society) Boston, MA 2010-present

Broomball Intermural Sports Boston, MA 2011-present

Floor Hockey Intermural Sports Boston, MA 2011-present Student Council (Class Secretary) Hingham, MA 2005-2009

SKILLS

MATLAB Computation

Python Programming Solidworks

Linux/UNIX

Microsoft Office FDA Regulations

Quality Documentation and Regulation

PERSONAL I am a very motivated, dedicated, and outgoing person, and I like to be challenged. I am great at working in groups and I thrive in fast-paced environments.

Thiagu Meyyappan Home Address

thiagu@bu.edu 4 Weston avenue

508-733-5712 Foxboro, MA 02035

OBJECTIVE

Seeking an entry level position in biomedical engineering

EDUCATION

Boston University College of Engineering, Boston, Massachusetts

Bachelor of Science: Biomedical Engineering ---graduating May 2013

Minor: Biology

Cumulative GPA: 3.48, GPA in major: 3.65

Relevant Courses: Stem cell Biology, Mol. Biology and Biotechnology, Immunology, Fluid Mechanics, Signals and

Systems in BME, Control Systems in BME, Organic Chemistry I/II, Biomedical Instrumentation,

Biomedical Measurements I/II, Product Design and Innovation, , Systems Physiology, Intro to

Electronics, Electric Circuit Theory, Intro to Computational Vision, Thermodynamics

Honors: Cum Laude, Merit Scholarship, Dean’s List, Alpha Eta Mu Beta Biomedical Engineering Honor society

RESEARCH EXPERIENCE

Microfluidic Perfusion Bioreactor for stem cell differentiation, Senior Design Project (September 2012 to Present)

Advisors: Joyce Wong, PhD (Biomimetic Materials Laboratory); Laertis Oikonomou, PhD (Center for Regenerative Medicine)

Designing a Microfluidic micro-bioreactor array for stem cell differentiation

Characterizing the microbioreactor through the use of fluorescence labeled molecules and time lapse imaging

Fabricating Microfluidic chip in PDMS (Polydimethylsiloxane) using soft lithography techniques

Designing an electromechanical fluid flow regulator that it is adaptable to any commercially available auto-syringe

Designing an elastomeric stencil to pattern embryoid bodies within cell culture chambers

Performing experiments to differentiate stem cells in a perfusion cell culture

o Testing the effects of perfusion vs. static cell culture on differentiation efficiency

Boston University Neuromuscular Research Center, Research Assistant (January 2012 to September 2012)

Advisor: Paola Contessa, PhD

Performed data analysis of electromyogram (EMG) signals from subject’s Vastus Lateralis and first dorsal

interosseous muscles

Ran analysis across multiple projects at the research center:

o Modeling and study of motor unit synchronization in healthy Adults

o Analysis of motor unit activity during isometric oscillating force activities

Programmed system to analyze motor unit firing rates and force oscillation frequencies

PROJECTS

A novel EOG-based communication system for patients with locked-in syndrome

Designed a system to allow patients with locked in syndrome to communicate through the use of eye movements

Programmed system to collect and convert EOG data to designated code symbols

Programmed system to convert designated symbols to sentences and verbalize the thought

VOLUNTEER ACTIVITIES

Student Food Rescue (September 2012 –Present) Boston, Ma

Volunteer, Massachusetts General Hospital ER (July 2011 – Present) Boston, Ma

Volunteer, Doolittle Retirement Home (2006-2008) Foxboro, Ma

SKILLS

Computer Skills: MATLAB, LABVIEW, SOLIDWORKS, MS Office

Molecular Biology: Tissue culture, Fluorescence Microscopy, DNA isolation, restriction digests, ligation, transfection

Chemistry: NMR, IR spectroscopy, column chromatography, spectrophotometry, titration, dilution, TLC chromatography

DIANA MINIOVICH

Box 5853, 140 Bay State Road, Boston, MA 02215 � dia456@bu.edu � 973-906-4304 EDUCATION

Boston University, College of Engineering, Boston, MA May 2013 Bachelor of Science in Biomedical Engineering • GPA: 3.68/4.0 Honors: Tau Beta Pi Honor Society, Alpha Eta Mu Beta Honor Society, Dean’s List

Senior Capstone Project Developed drug-loaded microbubble formulation for simultaneous detection and treatment of atherosclerosis resulting in a drug delivery platform that enhances early detection and decreases adverse drug side effects.

Selected Coursework Business of Technology and Innovation, Product Design, Supply Chain Engineering, Nanomaterials, Biomaterials, Thermodynamics, Fluid Mechanics, Control Systems, Molecular Cell Biology, Systems Physiology, Organic Chem.

WORK EXPERIENCE GE AVIATION- Lynn Manufacturing Operation May 2012 – August 2012 Early Identification Leadership Program Lynn, MA

• Delivered multiple improvements to standardize process and reduce cost by $1K/wk for GE90 engine line • Decreased production time by 2 hours, for both GE90 and LM2500 engine lines, by eliminating 1 braze cycle • Helped substantiate 2 new vendors to decrease production cost by $200K/yr and eliminate premium costs • Organized 15 person intern safety crew that focused on raising awareness in the plant through weekly events • Tracked shop gages across 2 plants to ensure all were in conformance with calibration certifications • Worked with 5 operators in union environment to facilitate process dialogues • Interfaced professionally on cross-function teams of engineers, quality leaders, vendors, and union personnel

PFIZER- Pharmaceutical Research and Development (PHRD) May 2011 – August 2011 Summer Intern Andover, MA

• Tested stability of ISCOMATRIX adjuvant in 11 formulations for future incorporation into vaccines • Collected and analyzed large data sets using 3 assays to deliver verdict immediately effecting drug formulation • Worked cohesively on a team of 8, published poster, and presented results in front of entire PHRD department

BOSTON UNIVERSITY– Biomedical Engineering Department March 2010 - Present Research Assistant Boston, MA

RUTGERS UNIVERSITY– Biomedical Engineering Department June 2010 – August 2010 Research Assistant New Brunswick, NJ

• Prepared DNA cross-linked hydrogels, bis-acrylamide hydrogels, and collagen hydrogels. • Plated, stained and fixed cells using florescent antibodies and imaged using fluorescent microscopy.

SKILLS Laboratory: Microfluidics, Liquid Chromatography, Dynamic Light Scattering, Cell Cultures, Hydrogel Preparation, SDS-

Page Electrophoresis, Western Blots, Antibody Staining, Fluorescent Microscopy, Spectroscopy Computer: MATLAB, Microsoft Office: Word, Excel, PowerPoint, Publisher Languages: Fluent in Russian, Conversational in Spanish

LEADERSHIP/ACTIVITIES BOSTON UNIVERSITY, Boston, MA TAU BETA PI HONOR SOCIETY May 2012– Present Vice President

• Organized events for 60 undergraduates to honor academic achievement and promote societal engineering RESIDENCE LIFE August 2011– Present Resident Assistant

• Provided advising, confronted and resolved issues, and enforced policy for 22 undergraduates. COLLEGES AGAINST CANCER October 2009– Present Treasurer, Chair of Food and Sponsorship Committee, Member

SYDNEY DANA MOY sdmoy@bu.edu

OBJECTIVE: An entry-level position with an emphasis on medical devices and diagnostics.

EDUCATION Boston University College of Engineering, Boston, MA

Bachelor of Science, Biomedical Engineering, May 2013, Magna Cum Laude

Dean’s List (5 of 7), Genzyme: Allston-Brighton Biotechnology Scholarship

Technische Universität Dresden (TUD), Dresden, Germany

Study abroad program, 20 credits, February – July 2011

Relevant coursework

Device and Diagnostics Design Solid Biomechanics Signals and Systems

Product Design and Innovation Medical Imaging Control Systems

Intro. Software Engineering Transport in Biological Systems Thermodynamics

PROJECTS

Global Health Senior Project: Alternative Ultrasound Gel for Resource Limited Settings

Design testing methods (viscosity, heat resistance, inertness) to measure electrical, mechanical and thermal properties of

ultrasound gels and substitute materials in order to develop an alternative ultrasound gel for a resource-limited setting.

Participated in the Rice 360: Beyond Traditional Borders Undergraduate Design Competition in Houston, TX.

Dream Valve: Designing an Artificial Heart Valve for Minimally Invasive Surgery

Design a novel artificial heart valve for minimally invasive surgery based on a lock-and-key method that will be deployed by

a transcatheter with emphasis on material selection.

VeriFLEXTM

Coronary Stent Cardiovascular Stent System Proposal

Acted as an R&D team for Boston Scientific to create a manufacturing proposal for the design and development of a coronary

stent. Followed FDA and international regulations for medical devices.

Eye Communication via EOG Data

Analyzed the electrooculogram data in order to understand vertical and horizontal eye movement.

Designed two separate systems based on human eye movements to control an LED circuit and move a computer cursor

simultaneously through MATLAB in real time.

EXPERIENCE Technology Innovation Scholar (Student Outreach Ambassador) Oct 2011–Present

College of Engineering, Boston University Boston, MA

Mentor at Cambridge Rindge & Latin for the FIRST Robotics Competition (2 years).

Visit and interact with elementary and high school students to discuss engineering and its impact on society.

Image Analyst Consultant July 2012–Jan 2013

inviCRO, LLC Boston, MA

Batch-processed imaging scans on biological species to analyze radiopharmaceutical uptake.

Developed and prepared study reports for continuation of software design improvement.

Laboratory Assistant Jan 2012–Apr 2012

BU Multi-Scale Tissue Biomechanics Laboratory Boston, MA

TECHNICAL SKILLS Laboratory: Spectrophotometry, bacterial transformation, EOG/EMG/EKG, biaxial tensile testing, calorimetry, ultrasound.

Computer: C/C++, Java, MATLAB, Solidworks, LabVIEW, MathCAD, LaTeX, LabScribe, ImageJ, WEKA, Unix/Linux.

Product Development: Knowledge of FDA Quality Systems Regulations, CE Marking, and ISO Quality Systems.

HONORS & ACTIVITIES Tau Beta Pi, Engineering Honor Society, Member

Alpha Eta Mu Beta, Biomedical Engineering Honor Society, Member

BU Society of Women Engineers (SWE), Secretary (2009 – Present)

Engineering Dean’s Host (2012 – Present)

BU Biomedical Engineering Society (BMES), Member (2010 – Present)

(617) 775-1795

78 Nottinghill Road

Brighton, MA 02135

Collin Neill 10 Buick Street Boston MA 02215 cneill.m@gmail.com 661.236.1521

Objective To use the engineering, computational and medical knowledge I have gained through my collegiate career to make an impact.

Skills Programming – MATLAB, Verilog(HDL), C#, XAML, C++, LabView

Microsoft Office, Visual Studio, Linux, Windows, GNU Compiler

General laboratory – Electrical Circuits, Chemistry, Biology

Technical Writing, Scientific Research Methodology, SDLC

Education Boston University College of Engineering Est. Graduation May 2013 with a Bachelors of Science in Engineering Major: Biomedical Engineering

Course Work I have completed courses in mathematics, biology, physics, economics, electrical circuits, mechanics, software, bioinformatics and neuro-engineering. In math I have advanced to differential equations and some topics in advanced calculus. For biology I have completed courses ranging from physiology to the principles of thermodynamics in biology. During my course work with electrical circuits I have used the following components: DC, AC, resistors, capacitors, inductors, op-amps, logic gates, micro-controllers, FPGA boards, bread boards, ELVIS system, diodes, and transistors. For various courses I have developed algorithms and models ranging from consumer minded to genetics.

Projects Truss design: Project Lead & Head Designer – Award I was the project lead as well as the designer of the truss. The design won an award for being best in class; during testing it held the most. The design also had the best cost to weight ratio. Verilog Tic-Tac-Toe Game: Project Lead & Developer Built custom game engine and AI in Verilog. The project was to only one to include options for both single and multiplayer modes. Lie Detector: Circuit Designer Built custom galvanic sensor, including a circuit for filtering and amplification. Combined an electrical circuit front with LabView backend. Android Game: Software Architect, Lead Programmer – Published Published an Android game to the Google Play store. Combined a Java front end for user interface along with a C++ backend for game mechanics. Bioinformatics: Lead Programmer – Published Developed software for PD-Loop discovery in Bacterium genomes. Results and algorithm are pending journal publication.

Experience

Research: Computational Neurophysiology Laboratory September 2012 – Present The project aims to develop and implement an interface for biologically inspired goal base navigation on various robotic platforms. Tools used: MATLAB, Microsoft Kinect. Developer - Intern; Avid Soccer May 2012 – Present Responsible for full SDLC including design and development of a team management app for the Windows phone platform; other platforms pending. The project was taken from concept to the current state of pre-market testing. Tools used: Visual Studio, C#, XAML, Silverlight.

Gregory Njus 447 Park Drive, Apt. 1B

Boston, MA 02215 gnjus@bu.edu (210)-722-9429

Goals I am an engineer looking for an industry position to increase my aptitude in the engineering profession and contribute my efforts to improve ongoing product development.

Education Boston University, Boston, MA Aug 2009 – May 2013

Majors: Biomedical Engineering, Neuroscience Cumulative GPA 3.50/4 Expected Graduation: May 2013

Relevant Coursework CH 203/214: Organic Chemistry, BE 420: Intro to Solid Biomechanics, BE 505: Intro to

Molecular Bio-Engineering, BE 526: Fundamentals of Biomaterials

Honors College of Engineering Dean’s List Recipient Fall 2011, Fall 2012 College of Arts and Sciences Dean’s List Recipient Fall 2010

Work Experience Research Assistant – Lab for Engineering Education and Development Sept 2012-Present

Developed modules for a microfluidic diagnostic that detects syphilis in resource-limited settings. The modules were particularly targeted to improve detection for asymptomatic congenital syphilis. Experience from working with Enzyme-Linked Immunosorbent Assays (ELISA) and Bulk Porous Polymer Formation was key during module designing.

Research Assistant – Cognitive Neuroimaging Lab May 2012-Present Acquired EEG data and analyzed spectral components to determine which frequencies in neural signal changed as a result of disambiguation during navigation tasks. Particular emphasis was placed on the time when changes in spectral power occurred. Additional experience with fMRI analytical tools was acquired during lab training.

Summer Research Assistant – Ritt Laboratory May-July 2010 Observation of rat whisker activity to create markers reflecting behavior changes during tactile exploration. Markers would then be used to create correlations with neural activity of whisker barrels.

Qualifications Lab –

Polymerase Chain Reactions, Gel Electrophoresis, Various Chromatography, Spectrophotometry, NMR\AA\IR Spectroscopy, Crystallization, Organic Synthesis, ELISA.

Computer – MATLAB®, EEGLab®, SPM8®Toolbox, LabVIEW®, OrCAD®, PSPICE®, Microsoft Excel®, Word®, and PowerPoint®.

Obiananma  Kimberly  Nwokike   CURRENT  ADDRESS  onwokike@bu.edu                                                                                                                                                                                                                                                                                              55  Cottage  Farm  Road  (203)  479  2362                                                                                                                                                                                                                                                                                                                Brookline,  MA  02446    OBJECTIVE    Highly  motivated  Biomedical  Engineer  seeking  an  Entry  level  Job  position  in  the  health  care  field    EDUCATION  Boston  University  College  of  Engineering,  Boston,  MA  

• Current  Senior,  B.S.  Biomedical  Engineering                                                                                                                                                                          Expected  -­‐  May  2013                                                                                                                                                                                                                                        • Dean’s  List  (multiple  semesters)  

Technische  Universität  Dresden,  Dresden,  Germany  • Semester  long  Engineering  Study  Abroad  Program                                                                                                                                                                                      Spring  2011  

Relevant  Coursework  Product  Design  and  Innovation     Business  of  Technology  Innovation   Human  Physiology  Biomedical  Measurements   Signals  and  Systems   Electric  Circuit  Theory  

 PROJECTS  Senior  Capstone  Project  –  Nanomedicine  and  Medical  Acoustics  Laboratory                                                                                                  Fall  2012  -­‐Present  Project  Title:  siRNA-­‐Microbubble  Conjugates  for  Ultrasound  Mediated  siRNA  Delivery  

• Designed  an  approach  of  coupling  siRNA  to  the  surface  of  microbubbles  for  therapeutic  delivery  into  endothelial  cells  to  degrade  the  expression  of  vascular  cell  adhesion  molecules-­‐1  (VCAM-­‐1)  that  led  to  atherosclerosis.    

• Modified  PEI  using  polyethylene  glycol  (PEG)  to  reduce  the  toxicity  and  promote  siRNA  transfection.    Student  Researcher  (Funded  by  UROP  &  Surf  awards)  Project  Title:  Lipid  Coating  of  Mono-­‐dispersed  Ultrasound  Contrast  Agents  for  Imaging  and  Targeted  Drug  Delivery  

• Developed  technique  of  coating  lipid  coated  microbubbles  with  biotinylated  PEG  to  make  them  more  stable  • Conjugated  microbubbles  with  fluorescent  nanoparticles  for  imaging  • Acquired  Brightness  Mode  (B-­‐mode)  images  of  the  microbubbles  using  portable  diagnostic  ultrasound  scanner  

 Central  Line  Placement  Device                                                                                                                                                                                                                                                        Spring  2013  -­‐Present  

• Designed  a  dual-­‐faced  ultrasound  transducer  probe  that  can  sense  whether  or  not  the  central  line  is  being  placed  in  an  artery  or  vein.    

• Developed  device  to  have  disposable  parts  and  to  be  easily  readable  by  clinician  while  performing  procedure  in  emergency  situation  

 Respiratory  Monitor  

• Designed  a  respiratory  monitor  using  a  speaker  that  acted  as  a  microphone.  • Developed  MATLAB  code  and  participated  in  presentation  prep-­‐activities  with  successful  results  

 HONORS,  LEADERSHIP  &  PROFESSIONAL  ORGANIZATIONS  National  Biomedical  Engineering  Honor  Society-­‐  Alpha  Eta  Mu  Beta                                                                                                                              Oct  2012  -­‐Present  Vice  President,  National  Society  of  Black  Engineers  (BU  Chapter)                                                                                                                  May  2012  -­‐Present  Senator,  Minority  Engineering  Society                                                                                                                                                                                                              September  2011  -­‐Present  Student  Advisor,  College  of  Engineering                                                                                                                                                                                                      September  2012  -­‐Present    VOLUNTEER  WORK  Pace  School  (Pittsburgh,  PA)  

• Worked  with  autistic  and  emotionally  unstable  children  (ages  5-­‐15).                                                                                                                      Spring  2012    SKILLS  

Laboratory:  Fluorescence  Spectroscopy,  Dynamic  Light  Scattering,  Extrusion,  Dialysis,  Lyophilization,  NMR,  Terason  Portable  Ultrasound,  Sonication,  Coulter  Counter  Particle  Analyzer,  Rotary  Evaporator  

Computer:      MATLAB,  Excel,  Microsoft  Office,  LabScribe,  SigmaPlot,  LabView,  ImageJ  

ANGELICA OCHOA 463 Park Drive, Apt 10, Boston, MA 02215 aochoa09@bu.edu • (209) 679-4230

EDUCATION Boston University - College of Engineering Boston, MA

B.S. in Biomedical Engineering, May 2013

GRE Q/V: 780/560, W: 5.0/6.0

Relevant coursework: Graduate: Computational Systems Biology, Neuroengineering, Nonlinear Systems, DNA Nanotechnology

Undergraduate: Product Design & Innovation, Control Theory, Signals & Systems, Biomedical Measurements, Electronics, Mechanics of

Materials, Fluid Mechanics, Thermodynamics, Systems Physiology, Cell Biology & Biotechnology, Probability & Statistics, Tissue

Engineering & Drug Delivery, Human Brain Mapping, Organic Chemistry, Bioethics

SKILLS Laboratory: Cryosection procedures, mammalian & bacteria cell culture, tissue sectioning & mounting, immunohistochemisty,

immunocytochemistry, small animal models & surgeries, cell metabolism, PCR, electrophoresis, DNA & RNA assays,

fluorescence spectroscopy, FACS, flow cytometry, spectrophotometry, buffer & staining solution preparation,

Computer: Proficient in MATLAB, SolidWorks, SPSS, Microsoft programs, image & signal processing

Equipment: Machining equipment, analog/digital electronics, soldering, oscilloscopes, function generators

WORK EXPERIENCE Smolina Research Group – Boston University Boston, MA

Research Assistant, Department of Biomedical Engineering, Sep 2012—Present

• Collaborated with research partner to design a universal binary probe that fluorescently detects nucleic acids in live cells

• Measured the fluorescence response of the probe in vivo and in vitro using FACS flow cytometry and fluorescence spectroscopy

• Developed an interactive MATLAB program to quantify the fluorescence response and signal to background ratio of the biosensor

Agios Pharmaceuticals Cambridge, MA

Summer Research Intern, Department of Metabolism, June 2012—Aug 2012

• Optimized biomass harvests from A549 cells (non-small cell lung carcinoma cell line) and RPMI medium for high-throughput

mass spectrometry (HT-MS) technology

• Determined the efficacy of Standard of Care cancer drugs and metabolic inhibitors on A549 cells using cell viability assays

• Collaborated with automation scientists to design and carry out large-scale studies to understand the metabolic effects of Standard

of Care cancer drugs on A549 cells

Highland Instruments Cambridge, MA

Laboratory Assistant/Supervisor, Feb 2011—May 2012

• Oversaw all laboratory activities including invasive small animal surgeries and histological analyses on sectioned nervous tissue

• Oversaw and trained students working in the lab to perform general lab duties and assist with preparation of buffer and staining

solutions required for histochemical staining procedures

• Ran various stains on sectioned nervous tissue to detect neural damage to ensure safety and efficacy of brain stimulation device

• Directly corresponded with CSO and PI to communicate status updates, set deliverables, and maintain the lab

Beth Israel Deaconess Medical Center1 Boston, MA

Research Intern, Department of Surgery, May 2011—Aug 2011

• Performed cell culture procedures to maintain and proliferate neural progenitor cells (NPC) and endothelial cells (EC) that were

co-cultured in well-plates to determine degree of vascular network development in the presence of NPC

• Performed surgeries to harvest brains of mice that underwent induced strokes and were injected with a co-culture of NPC and EC

to promote enhanced survival of the transplanted NPC

• Sectioned nervous tissue and performed immunocytochemical stains to evaluate degree of neurovascular regeneration post-stroke

• Developed MATLAB program that determined degree of vascular network development from images processed from well-plates

ASSOCIATIONS AND INTERESTS

• Inspiration Ambassador for Technology Innovation Scholars Program at BU Oct 2011—Present

• FIRST Robotics Mentor for Boston University Academy Jan 2012—March 2013 • Volunteer at Children’s Hospital Boston Sep 2010—Sep 2011

• Women in Science and Engineering Program at BU, member since September 2009

• Society of Hispanic and Professional Engineers (SHPE), member since September 2009

• Society of Women Engineers (SWE), member since September 2009

AWARDS AND HONORS • Award Recipient for Outstanding Leadership and Commitment to Science and Engineering by MAES April 2012

• Boston University Grant Recipient Sep 2009—May 2013

• Excellence in Engineering Book Award Sep 2011— May 2013

PUBLICATIONS 1) Vissapragada, R, et al. (2013) Bidirectional crosstalk between periventricular endothelial cells and neural progenitor cells

promotes the formation of a unique neurovascular unit. PLoS ONE. Submitted 03/2013

Kristen O’Leary 33 Harry Agganis Way, Box 9806, Boston MA 02215 (862)-221-2843 oleary.kristen@gmail.com

Objective To obtain a full-time engineering position upon graduating in May 2013

Education Boston University College of Engineering Boston, MA Bachelor of Science in Biomedical Engineering Expected: May 2013 Minor: Mechanical Engineering Current GPA: 3.5/4.0 (Cum Laude)

Related Coursework: Biomedical Product Design, Mechanical Product Design, Computer Aided Design and Manufacturing, Materials Science, Static Mechanics, Dynamics, Thermodynamics, Signals and Systems, Electric Circuit Theory

Experience Spaulding National Running Center Cambridge, MA Undergraduate Design Researcher September 2012 - present

• Designing a real-time feedback system that can provide accurate information on a person’s landing strike pattern while barefoot running, on a team of three

• Programming and assembling an accelerometer Arduino platform ankle-brace to obtain data from sensor measurements on the patients’ feet

• Developing a processing algorithm using MATLAB/Processing (Java) to distinguish which data represents proper foot strike patterns

• Contributing towards Harvard Medical School faculty research to aid in diagnosing injury-inducing heel-strike landing patterns in recovering runners

Boston University School of Medicine- Dept. of Physiology and Biophysics (Moore Lab) Boston, MA Undergraduate Research Assistant March – August 2011

• Conducted an independent research project on “The Regulatory Factors in Muscle Contraction” • Used an in-vitro motility assay to record the behavior of chicken skeletal myosin and actin filaments

under a fluorescent microscope • Processed video recordings of cell movement and calculated filament contractile speeds using Image J • Examined the effects of ATP concentration, Calcium concentration, and the addition of muscle regulatory

proteins troponin and tropomyosin on the rate of muscle contraction as baseline measurements for Familial Hypertrophic Cardiomyopathy mutant tropomyosin comparisons

NicePak Products/ P.D.I. Valley Cottage, NY Research & Development Intern June – August 2010

• Established regulated chemical specifications of home cleaning products, sterile medical wipes and alcohol swabs through collaboration with professional chemists

• Developed prototype cleaning wipes from start to finish- mixed chemical compounds, cut and selected material, and packaged/pilfer sealed containers

• Ran weekly stability tests on new products for Quality Control Scientists including tensile material testing, pH measurements, and liquid viscosity evaluations

Activities, Societies, and Honors Biomedical Engineering Society – Social Chair, College of Engineering Dean’s Host, Tau Beta Pi Engineering Honor Society, Alpha Eta Mu Beta Biomedical Engineering Honor Society, Dean’s List - Multiple Semesters, Valedictorian of Pequannock Township High School Class of 2009

Skills Computer: MATLAB, Processing (Java), SolidWorks, FEA, FMEA, Image J, C-Motion Visual 3D, Labview, Microsoft Office Basic Machining: Band saw, Scroll Saw, Milling, Lathing, Sanding/Polishing

RELEVANT WORK EXPERIENCE

Tengeru Hospital Arusha, Tanzania Volunteer Laboratory Technician June 2012 -  Administered laboratory tests including blood tests for malaria, HIV, CD4 count, hemoglobin levels, as well as urine tests for

glucose and protein levels -  Assisted physicians in minor surgery and emergency response departments -  Organized patient registration system and hospital records Mentors For Africa Philadelphia, PA Intern July 2012 – August 2012 -  Collaborated with organization founder to plan future goals and organization growth -  Coordinated weekly live meetings with partners in Tanzania and participated in post-meeting evaluations and planning -  Identified areas of improvement in a growing not-for-profit organization and proposed new developments -  Facilitated and implemented a more comprehensive and user-friendly website design

ADDITIONAL WORK EXPERIENCE

College of Arts and Sciences Information Technology Boston, MA Front Desk Attendant September 2012 – Present -  Managed phone correspondence with Boston University faculty and staff -  Responsible for the organization and management of all office equipment available for rental as well as scheduling for

technician appointments and classroom reservations -  Register customers and communicate with technicians through Boston University’s online ticketing system Pathway Home Realty Group Boston, MA Assistant September 2012 – Present -  Manage employee’s personal and professional expenses, including calculating deductibles and filing tax returns -  Organize employee’s personal and professional work space to improve efficiency and productivity -  Implemented a personalized filing system to improve management and organization of professional documents and records

RELEVANT PROJECTS

Massachusetts Institute for Technology Boston, MA Blood Glucose Monitoring System for Use in Developing Countries September 2012 - May 2013 -  Designed a comprehensive system for diabetes management in developing countries including access to blood glucose

monitoring technology, patient records, frequent communication with physicians, and educational feedback -  Developed a patient identification system, online database, and Android application to store and communicate the data

collected -  Fabricated a mechanical system designed for sanitary blood glucose testing and accurate data recording in a developing country

EDUCATION Boston University Boston, MA -  Expected graduation May 2013 -  Bachelors of Science in Biomedical Engineering -  Dean’s List: Spring 2011; Fall 2012 Queen Mary University of London London, UK -  Five month study abroad program

Shannon O’Neill (610) 724-4991 • saoneill26@gmail.com

ACTIVITIES - Alpha Delta Pi Sorority SKILLS - MATLAB, Python, Java, SolidWorks, Adobe Illustrator - Proficient in Mac, Windows, and Linux

RELEVANT COURSEWORK -  Functional Genomics & Epigenetics -  Advanced Clinical Measurements & Device Design -  Applications in Bioinformatics -  Neuroscience: from Molecules to Behavior -  Intellectual Assets: Creation, Protection, & Commercialization

Courtney Pacheco

ABOUT ME I am a highly motivated Master's candidate at Boston University with a strong passion for software engineering and digital signal processing. I am also diligent worker who enjoys working in interdisciplinary teams and who enjoys partaking in challenging projects.

EDUCATION Boston University (BU) College of Engineering Bachelor of Science in Biomedical Engineering (B.S. BME), Expected May 2013 Master of Engineering in Computer Engineering (M.Eng CE), Expected May 2015

PROJECTS Owl Classification Algorithm (Feb 2013 - April 2013) Devised a learning algorithm in MATLAB to classify select owl species based on the frequency content of their calls. This learning algorithm utilizes cepstrums, FFTs, and correlation coefficients.

EEG Classification of Heard and Imagined Speech (Aug 2012 - Current) The goal of this project was to determine the feasibility of classifying heard and imagined speech using electroencephalographic (EEG) signals as inputs to a support vector machine (SVM). Classification was attempted on a closed set of three speech tokens (/2/, /7/, and /11/), and all signal processing was done entirely in MATLAB.

The Precedence Effect (May 2012 - Current) Investigated the psychoacoustic and brainstem responses to the Precedence Effect, a psychoacoustic effect that causes listeners to fuse two sounds together when the sounds are separated by a sufficiently short time delay. Also designed a MATLAB graphical user interface (GUI) that (1) generates auditory stimuli, (2) presents the stimuli, (3) controls the recording of EEG data, and (4) records subjects' psychoacoustic responses.

Neural Interface Mechanism for Wireless Typing (Nov 2011 - Dec 2011) Designed an 8-key keyboard with MATLAB's GUI feature that allows users to type with their eyes in real time by using electrooculography (EOG) to capture their eye movements. An algorithm was developed to interpret these movements in real time, which allows users to see on the GUI screen, in real time, which letters they typed.

SKILLS Coding o MATLAB (Specialties: GUI design &

development, machine learning algorithms, signal processing)

o C / C++

Digital Signal Processing Microelectronic Circuit Design Electroencephalography, electrooculography,

electrocardiography acquisition, processing, and interpretation

RELEVANT EXPERIENCE

Auditory Neuroscience Laboratory (Boston University) Research Assistant (11 months & Counting) EEG signal acquisition, processing, and interpretation Engineering experiment design and development BAE Systems WISE Intern (5 months) Simple circuit building, debugging, and soldering Processed simple digital signals Basic robotics programming

Boston, MA May 2012 - Current Nashua, NH Nov. 2008 - Mar. 2009

AWARDS

Dean's List Top 30% of class

Boston University Fall 2012 Semester

ACTIVITIES BU Premedical Society, BU Concert Band

Bhavesh D. Patel 13 Carmen Terrace (781) 541 0936

Woburn, MA 01801 bhavesh@bu.edu

OBJECTIVE Highly motivated engineering student interested in an R&D position at a leading medical device company.

EDUCATION

Boston University College of Engineering, Boston, MA Master of Engineering in Mechanical Engineering May 2014

B.S. Biomedical Engineering, Minor: Electrical Engineering, GPA:3.44/4.00 May 2013

EXPERIENCE

R&D Engineer September 2012-Present

Wyss Institute at Harvard University Boston, MA

Senior Design Thesis: “Stochastic Resonance Ankle Brace for Improving Balance Control”

Designed and constructed an ankle brace implementing stochastic resonance technology by mechanically

delivering white noise to mechanoreceptors in the ankle.

Programmed Arduino microcontroller and designed printed circuit board schematic and layout.

Developed a human study to determine the functional improvements of stability and balance control when

wearing the prototype ankle brace.

R&D Biomedical Engineering Intern May 2012-September 2012

Medtronic: Advanced Energy-Spine and Neurology Franchise Portsmouth, NH

Developed and conducted bench-top and in-vivo porcine model feasibility test protocols with electrosurgical

devices that hemostatically seal soft tissue and bone.

Worked with a cross-functional team involving members from marketing, quality and manufacturing.

Compiled and analyzed pre-clinical data for FDA submission.

Designed test fixtures for experimentation.

R&D Engineering Intern January 2012-May 2012

Little Devices/D-Lab at Massachusetts Institute of Technology Cambridge, MA

Developed the fabrication method of modular microfluidic chips for physicians to create their own diagnostic devices and solutions for their patients in rural communities.

Designed chips with unique functions and channel orientations.

PROJECTS

Product Development: “Medtronic Talent Stent Graft” Evaluated Medtronic stent graft system from a product development standpoint; 4 team member project.

Developed feasibility test plan, including proof of principle and killer experiments.

Created functional & performance specifications and developed FDA plan with design processes following

21 CFR 820 and conducted FMEA.

Biomedical Instrumentation: “Acoustic Heart Rate Monitor” Designed and coded an auditory heart rate monitor device using an ECG setup; 5 team member project.

Device played a live audio representation of the “lub & dub” sounds caused by the closing of atrial

ventricular valve and semilunar valves respectively.

Entrepreneurship: “Hygenx” Took up primary leadership role for mock-startup company serving as the Chief Technology Officer. 10 year Business Plan & Financial Plan was established along with acquiring actual potential customers. Gained and developed understanding of business entrepreneurship, elevator pitches, and presentation skills.

SKILLS

SolidWorks ImageJ Vicon Arduino Medical Device Product Development

MATLAB Eagle MiniTab SigmaPlot Microsoft Office Suite

ACTIVITIES & AWARDS

Biomedical Engineering Society (BMES)- President of BU Chapter and attended National BMES Conference 2012.

Alpha Eta Mu Beta (AEMB)- National Biomedical Engineering Honor Society, Top 30% of class.

College of Engineering Dean’s Host- Conducted campus tours and served as a student representative at formal functions.

13 Hitching Post Ln Salem NH, 03079

Phone: (603) 479-9534 Email: kp3190@bu.edu

Kripa B. Patel

Objective: Biomedical Engineer with a strong background in physics, optics and microbiology research pursuing a challenging and high impact R&D position.

Skills: Computer: LabView, C++, Root, Matlab, SolidWorks Laboratory: Mammalian and bacterial cell culture, PCR, restriction enzyme digestion, DNA and protein gel electrophoresis, Western blotting, cell transformation and transfection, cell counting, large and small-scale plasmid preparation, fluorescence microscopy, ImageJ Languages: Gujarati, Conversational in Hindi and French

Awards and Honors

BU Trustee Scholarship, Tau Beta Pi Honor Society, AEMB Honor Society, Dean’s List (6 semesters), UROP Grants for research at CERN and BU Medical, Co-valedictorian of Salem High School in Salem, NH.

Experience Biomedical Optics Lab, Boston University Aug 2012 - Present Senior Project: Developing a system to assess cancer cell morphology using scattered light Designed and machined a novel optomechanical system to image scattered

light from cell samples Optimized a Matlab program to collect and analyze experimental data and

compare to theory

TERA Foundation, CERN, Geneva, CH Jan – Aug 2012 Developed and tested software and electronics for two novel medical imaging systems for use in cancer hadrontherapy as part of a four person team. Wrote optimized image processing and electronics control subroutines in

LabView and C++. Modeled various commercially available and novel PET scanners with

Monte Carlo simulations in the GEANT4 program, GATE. Demonstrated the unfeasibility of a PET design employing a novel gamma

particle detector before the project reached prototyping phase.

Cancer Research Center, Boston University Medical Sept 2010 - Aug 2011 Quantified effects of five specific microRNAs present in abnormal levels within cells infected by Moloney murine leukemia virus. Transfected short hairpin RNA into cells and analyzed subsequent effects

on nkKB gene expression and apoptosis. Only undergraduate to present research during Evans Days poster session

BioConcept Laboratories, Salem, May – Aug 2010 BU summer Co-op program Junior lab technician in GMP/GLP biotechnology and chemistry labs

Formulated ophthalmic solutions and tested for pH, osmolality, microbial content, and purity by HPLC analysis and spectrophotometry.

Education

Boston University 2009 - 2013 B.S. Biomedical Engineering, B.A. Physics 3.6 GPA Trustee Scholar (Full-tuition merit scholarship program) University of Geneva, Geneva, Switzerland Spring Semester Abroad 2012

Involvements Senior Editor and Writer, Synapse Science Magazine 2010 - 2012 Grader, EK102: Linear Algebra Fall 2012 Member, BU BME Society, SWE, Indian Club 2010–Present

Relevant Coursework Medical Imaging, Optical Microscopy, Mechanics of Biomaterials, Signals and Systems, Control Systems, Organic Chemistry, Cell Biology and Biotech, Systems Physiology, Electricity and Magnetism, Quantum Mechanics, Thermodynamics, Electric Circuit Theory

KELSEY A. PETERSENSchool Address Permanent Address65 St. Mary’s Street, Apt 2 174 Garden RoadBrookline, MA 02446 732 977 5646 petersenk29@gmail.com Shrewsbury, NJ 07702Education Boston University College of Engineering, Boston, MA Bachelor of Science, Expected May 2013 Biomedical Engineering, Major Mechanical Engineering, Minor Dublin City University, Dublin, Ireland Study Abroad Program Fall 2011 Cambridge University, Cambridge, England Summer Study Program in Biomedical Ethics and Super String Theory Summer 2009Coursework Control Systems Biology, Material Science, Systems Physiology, Thermodynamics, Product Design, Diagnostic and Device Design, Molecular Cell Biology, Fluid Mechanics, Mechanics of Materials, Electric Circuit Theory, Computer Aided Design, Engineering ComputationProject Characterization Device for Esophageal Atresia Surgery Boston University Senior Project Current 2012-13 The Wyss Institute for Biologically Inspired Engineering at Harvard University Boston, MA • Designed a test bench model to provide basic characteristics for current esophageal atresia surgeries, and for the future use of a custom esophageal tensiometer to be implemented in surgeries at Boston Children’s Hospital. • The end goal is to design a tissue growth function related to time and force to optimize a re-tensioning procedure during surgery and shorten surgery duration.

Experience Research Assistant - Internship Summer 2012-Current The Wyss Institute for Biologically Inspired Engineering at Harvard University Boston, MA James Niemi, Leia Stirling PhD, Amanda Wozniak • Collaborated on sensory enhancement insole project to evaluate stochastic resonance insole devices, explore actuator and displacement assessment technologies, and support pilot clinical studies and human testing. • Collaborated on stochastic resonance active knee brace to evaluate device construction, explored next prototype revisions, researched other knee stimulation options, and performed human testing.

Shadowed Dr. Saad A. Saad at Meridian Pediatric Surgery Winter 2011 Saad A. Saad, M.D., FACS, FAAP Tinton Falls, NJ Pediatric Surgeon-in-Chief of K. Hovnanian Children's Hospital • Oversaw daily office policies and patient care • Worked directly with patients and families to diagnose illnesses, learn about each individual patients’ future treatment care, and how to design treatment plans to reassure the patient and families

Research Assistant - Volunteer Summer 2011 Boston University’s Optical Characterization and Nanophotonics Lab Boston, MA Professor Mario Cabodi and Carlos Lopez (Post-Doc) • Performed the optical characterization of the binding of sample fluid flow over a silicon microarray chip spotted with a variety of antibodies using IRIS technology • Characterized the least massive sample fluid and type of microarray which could obtain accurate results of binding using both solid silicon microarray chips and slotted silicon microarray chips

Skills MATLAB, SolidWorks, LabView, Laser Cutting, IRB revisions, MTI displacement systems, Soldering, Microsoft Word, Excel, and Powerpoint

Activities & Boston University Engineering Dean’s Host Member since 2011 Interests Society of Women Engineers Member since 2010 Boston University Women’s Varsity Rowing Fall 2009 - Fall 2010

EMILY C. POLSON 7 Ashford St Apartment 1 / Boston MA 02134

(415) 786-1737 / epolson@bu.edu

Objective A full time position in the field of biomedical engineering. Education Boston University College of Engineering Boston, MA

Bachelor of Science, Biomedical Engineering May 2013 Concentration in Nanotechnology GPA: 3.17 Dean’s List Recipient Dean’s Merit Scholarship Recipient Technische Universität Dresden Germany six month study abroad program. February-July 2011 Select Courses Product Design/Development Thermodynamics

Immunology Cell Biology/Systems Physiology Intro to Mechanics Signals and Systems Nanomaterials/technology Control Systems in Biology Electric Circuit Theory Fluid Mechanics

Projects Senior Project: Targeted Nanoparticles for Sustained Intracellular Drug Release

Designed a drug-polymer conjugate to control drug release of nanoparticle. Tested rate of release from drug-polymer conjugate as a function of polymer length. Synthesized nanoparticle using a drug conjugated polymer. Tested cell toxicity of nanoparticles.

Experience Researcher / BU Nanomedicine and Medical Acoustic Lab November 2011-present

Constructed drug loaded polymer micelles and studied the pH sensitivity of drug release. Used spectrofluorophotometer to make calibration curve of drug fluorescence. Synthesized nanoparticles. Tested drug release at differing pH using calibration curve and fluorescence. Media Assistant / BU Classroom Technology Services August 2010-present Assisted professors with the media technology in their classrooms. Provided customer service to clients with technical problems.

Skills Matlab, Dynamic Light Scattering, Rotary Evaporator, Sonicator, Micropipetting, Cell Culture, Excel, SigmaPlot, Adobe Photoshop, Photography, HTML, Spanish

Activities Vice President / BU Synchronized Swimming September 2011-present

Organized and led fundraising events. Assisted the president in team communication and administrative tasks. Dean’s Host/ BU College of Engineering January 2010-present

Jason W.Y. Pui

linkedin.com/in/jasonpui | jasonpui@bu.edu

> EDUCATION Boston University College of Engineering Boston, MA Bachelor of Science in Biomedical Engineering, Dean’s List: multiple semesters May 2013

> WORK EXPEREIENCE Medtronic Advanced Energy, R&D Surgical Oncology and Adv. Laparoscopy May 2012 – May 2013 Biomedical Engineering Intern Portsmouth, NH Collaborated with a surgeon to design new device concepts with SolidWorks. Designed, programed and built two automated quality testing equipment to improve CTQ assessment. Established and executed protocols for performance testing based on IEC certification as per FDA

requirements, including orchestrating an animal lab according to good laboratory practices (GLP) guidelines.

Wrote, revised and reviewed Test Requests, Protocols and Test Reports for various testing procedures and conducted equipment verification (OQ, PQ) as well as prototype validation.

Submitted an invention disclosure and an independent research grant application.

Harvard Medical School, Brigham and Women’s Hospital September 2012 – May 2013 Undergraduate Design Engineer Boston, MA Worked as a team of 3 to design and build a modular, wirelessly controlled and powered endoscopic bot. Composed project proposals and progress reports outlining specific aims, achievements and deliverables.

Boston University, Department of Biomedical Engineering January 2011 – May 2012 Undergraduate Researcher Boston, MA Assessed the effects of stiffness and permeability on engineered microvessels derived from human

endothelial cells in fabricated collagen scaffolds. Measured the permeability, lifespan, and flow rate of microvessels as a function of scaffold stiffness and

conductivity.

Seattle Central Community College, Department of Biology September 2009 – June2010 Undergraduate Researcher Seattle, WA Obtained independent funding to investigate the effects of free-radical uptake by varying concentrations

of antioxidants on Dictyostelium discoideum morphology. Presented poster titled “Effects of Free-Radical Inhibition on the Multicellular Differentiation of

Dictyostelium discoideum” at the Undergraduate Research Symposium at the University of Washington.

> PROJECTS Si6 Anti-Malware Technology Commercialization January 2013 – May 2013 Worked with a scientific founder to comprehend the capabilities and potential impact of his Si6

Technology. Assessed market competition and created tailored surveys and personally contacted potential customers

ranging from Medtronic IT to Verizon Enterprise Solutions. As a team of 3, evaluated customer response to assess the market need and benefits of Si6, as well as to

determine the best packaging and delivery methods for successful commercialization of technology. Created technology one-pagers, executive summaries and submitted a commercialization strategy

proposal, which included a financing plan to the scientific founder.

> ACHIEVEMENTS and HONORS Boston University 5k Business Ideation Competition, Champion Team 2013 > Won $4k award money for best business idea comprising ideation, business planning & pitch. Alpha Eta Mu Beta Biomedical Engineering Honor Society, Chapter President 2012-2013 > Lead an organization of 60 members; secured & managed over $10k in event funding. Hugh Canon Foundation Scholarship, Recipient 2009

> SKILLS Technical: MATLAB, Java, Mathematica, SigmaPlot, SolidWorks, ImageJ, Microsoft Office Suite Languages: Fluent in Mandarin & Malay. Some proficiency in Hokkien, Taiwanese, Cantonese Other interest: Product Development, Business Development, Finance, Marketing, Six Sigma, Volleyball, Travel

ALBERTO PURWADA 150 Brookline Avenue #1207 Boston, MA 02215

(617) 820-7195 | purwada@gmail.com

EDUCATION

Boston University, College of Engineering, Boston, MA Bachelor of Science, summa cum laude, Biomedical Engineering, May 2013 GPA: 3.86/4.00 GRE: 167 (Q), 166 (V)

Relevant Coursework: The Business of Technology Innovation, Introductory Microeconomic Analysis, Introductory Macroeconomic Analysis, Research Writing on Innovation in Technology and Science, Engineering Computation, Multivariate Calculus, Differential Equations, and Introduction to Probability.

AWARDS

Kenneth R. Lutchen Distinguished Fellowship Tau Beta Pi (Engineering Honor Society) Alpha Eta Mu Beta (Biomedical Engineering Honor Society) IGEM Best Software and Gold Medal Awards Summer Term Alumni Research Scholars UROP Student Research Award for four semesters Dean’s List for seven semesters

2012 2012 2012 2011 2011

2010-2012 2010-2012

PROJECTS

Business Plan for Wearable Fitness Monitor Developed a business plan to commercialize a hypothetical wearable fitness monitor. Performed research to analyze market potential, assess the competing products, evaluate market ecosystem, and prepare financial projections. Utilized case studies from Harvard Business School to develop market adoption strategies. Product Development Plan for Cardiovascular Stent Researched scientific literatures to understand the clinical needs and the limitations from current clinical practices. Assessed patent database and devised the strategy for preparing, filing, and maintaining patents. Evaluated FDA documents to determine the regulatory pathways, the quality control procedures, and the appropriate validation plan. Microfluidics-based Perfusion Bioreactor for Stem Cell Differentiation Constructed microfluidic chips to culture stem cells under perfusion, performed computational modeling, designed elastomeric stencils to pattern cells, and collaborated with mechanical engineers to automate stem cell differentiation. Electrooculogram (EOG)-based Typing Mechanism Combined electronic hardware and MATLAB algorithm to convert eye gaze into specific letters in real time to assist the communication of people with physical disability. Devised an experimental apparatus to record changes in electrical dipole around the eye while gazing. Developed a program that sampled the digitized data in regular time interval.

WORK EXPERIENCE

Biomimetic Materials Engineering Laboratory, Boston University

2010-Present Research Assistant Calculated the displacement of fluorescent beads by smooth muscle cells to quantify the relationship between cell traction force, substrate stiffness, and matrix protein types. Characterized the mechanical properties of thermoresponsive polyacrylamide hydrogels to develop a temperature-controlled method for cell sheet production. Scientia Advisors 2012 ScientiaNet Intern Performed research to organize life science companies based on their areas of expertise. Utilized MATLAB to automate the acquisition of business contact information and upload the resulting data into the internal company database. Center for Interdisciplinary Design Automation Research Laboratory, Boston University 2011 Research Assistant Constructed genetic circuits that were capable of sensing arabinose with varying concentration and responding with fluorescence with proportional intensity. Submitted the completed genetic circuits into the database of biological parts.

PRESENTATIONS A. Purwada, B.C. Isenberg, O.V. Sazonova, M.A. Nugent, and J.Y. Wong. SMC Traction Force Generation is Modulated by Substrate Stiffness and Ligand Presentation. BMES Annual Meeting, Atlanta, GA, 2012.

SKILLS Programming: MATLAB, Python, BASIC Computer: Word, Excel, PowerPoint, Front Page, Metamorph, ImageJ, Adobe Photoshop, Adobe Dreamweaver Laboratory: Molecular Cloning, Genetic Engineering, Cell Culture, Cell Traction Force Microscopy, Soft Lithography

OTHER ACTIVITIES

Consultant, Health Technology Entrepreneurship Commercialization Consultants (TECC) Secretary, Alpha Eta Mu Beta (BME Honor Society) Tutor, College of Engineering Vice President, Engineering Student Government

2012-Present 2012-Present 2011-Present

2010-2011

SURAJ RAMA Suraj@bu.edu | 732-857-0531 | US Citizen | www.linkedin.com/in/surajrama|www.surajrama.com

OBJECTIVE: Seeking an active role in R&D or product design to develop medical devices.

EDUCATION: Boston University - BS in Biomedical Engineering, 2013 (Concentration in Nanotechnology)

EXPERIENCE

Medtronic – Advanced Manufacturing Engineer Intern May 2012 – January 2013

Designed and fabricated prototype guide catheter and guide wire based medical devices from either a

detailed specification, or a less defined customer need or intent Performed analysis of guide catheter and guide wire based medical devices in an effort to develop a

method of manufacture which leveraged existing manufacturing technologies within the facility Assessed device, process, or material performance against established standards or specifications Provided engineering support in product transfers from R&D to manufacturing Established and maintained equipment for medical device manufacture

Beth Israel Hospital Diagnostics – Equipment Technician Volunteer September 2011 – Present

Repair hospital equipment in cardiology and surgery departments

Test and calibrate diagnostic equipment (eg. ECG, Ultrasound, Endoscope)

BUMC Infectious Diseases Laboratory – Research Assistant May 2011-September 2011

Developed an effective allergy treatment with reduced side effects

Isolated CD23, an IgE blocker, and modified its structure to increase efficacy

To test the efficacy of our drug, ET5253, IgE binding assays were carried out using THP-1 and CRL cells

Laboratory for Micro System Technologies – Research Assistant September 2010 – May 2011

Created alternative drug eluting and biodegradable stent deployment system

Designed a polymer based biodegradable stent from the carbon skeleton of wood

Tested the radial strength and flexibility of proposed design using COMSOL

SteriPharm Medical Devices – QA Engineering Intern May 2010 - September 2011

Tested new line of cardiac stents for mechanical properties

Conducted performance specification tests and ensured safety of new stent designs

Prepared patents, technical reports, proposals and publications for new innovative technologies

PROJECTS

Boston University Senior Design September 2012 – May 2013

Designed and prototyped wireless powered modular capsule robots capable of being controlled via radio

control

Build 4x scale prototype to demonstrate locomotion and docking ability

Boston University Smart Lighting Design Competition April 2011

Designed a novel solution for retrieving data encoded in “smart light”

Presenting design, applications, and business plan to a panel of judges

RELEVANT COURSES

ENGINEERING BUSINESS

Fluid Mechanics Control Systems Differential Equations Micro/Macro Economics

Solid Mechanics Electric Circuit Theory Molecular Cell Biology Financial Accounting

Bioinstrumentations Signals & Systems DNA Struc. & Func. Managerial Accounting

Thermodynamics Molecular Biotechnology Probability and Statistics Product Development

SKILLS

Software: Minitab, SolidWorks, MATLAB, LabScribe, LABVIEW, BLAST, RSLogix, COMSOL

Other: DOE, FMEA, ISO, IQ, OQ, PQ

Laboratory: Ultraviolet spectrophotometer (UV-Vis), infrared spectrophotometer (FTIR), Karl Fischer Titration,

preparing reagents, fluorescent microscope, cell culture, gram stain, DNA splicing and replication,

electrophoresis, UV lithography, electroplating, nanofabrication, injection molding

Varuna M. Rao 7636 S. 94th East Avenue, Tulsa, OK 74133 ▪ vmrao17@bu.edu ▪ (918) 813-2704

EDUCATION Boston University, College of Engineering, Boston, MA

Bachelor of Science in Biomedical Engineering, May 2013

Dean’s List

EXPERIENCE Research Assistant, Matrix Mechanotransduction Laboratory, Boston University, Boston, MA 9/12 – 5/13

� Assembled a fluorescently micropatterned hydrogel cultured with endothelial cells in a Glycotech parallel plate

flow chamber

� Applied fluid dynamics to determine effect of wall shear stress on hydrogel

� Practiced microscopy techniques to image cell deformation due to fluid shear stress and contractile forces

� Measured traction forces of endothelial cells to better understand and prevent vascular diseases

Research Assistant, Brain and Vision Research Laboratory, Boston University, Boston, MA 9/10 – 5/12

� Processed fMRI scans using FreeSurfer which included motion correction, spatial normalization and

spatial smoothing

� Reconstructed anatomical fMRI scans and visualized areas of activation under numerous experimental parameters

� Analyzed brain images to determine statistical significance of activation

Research Assistant in Aerobiology Laboratory, University of Tulsa, Tulsa, OK Summers ‘10 – ‘11

� Trained in pollen identification and pollen counting methods using microscopy techniques

� Monitored unhealthy pollen counts, specifically cedar pollen, as a warning system for allergy sufferers

Junior Volunteer Program Coordinator/Intern, Hillcrest Medical Center, Tulsa, OK Summers ‘10 – ‘11

� Coordinated summer volunteer program for over thirty high school students by placing them in

hospital departments after reviewing applications, conducting interviews, and leading orientation

� Met with healthcare workers and hospital staff to provide an educational experience for volunteers

� Observed physicians in the departments of pathology, cardiology, radiology, neonatology, and engineering

PUBLICATIONS & PRESENTATIONS Rao, Varuna. “Face Recognition: Is It a Match?” Oklahoma Junior Academy of Science, vol. 36, Mar. 2009.

Poster presentation to the American Junior Academy of Science (AJAS) for “Face Recognition: Is It a Match?”

American Association for the Advancement of Science (AAAS) meeting, San Diego, CA, Feb. 2010

EXTRACURRICULAR ACTIVITIES Volunteer in Medical Career Exploration Program, Brigham and Women’s Hospital, Boston, MA

Student Advisor for Summer Orientation, Boston University, Boston, MA

Member of Biomedical Engineering Society, Boston University, Boston, MA

Secretary of Society of Asian Scientists & Engineers, Boston University, Boston, MA

Volunteer at University of Oklahoma Bedlam Clinic, Tulsa, OK

Peer Mentor for Women in Science and Engineering (WISE), Boston University, Boston, MA

Volunteer for Habitat for Humanity, Boston University, West Palm Beach, FL

SKILLS Computer: Matlab, SigmaPlot, ImageJ, LabView, FreeSurfer, MathCad, Mathematica, Metamorph Basic, Microsoft Office

Lab: Nuclear magnetic resonance imaging, Infrared spectroscopy, Gas chromatography,

Thin layer chromatography, Microscopy, Polymerase chain reaction, Gel electrophoresis

FIONA A. RASO 10 Weed Road 203.770.8944 230 Babcock St Apt 4G

Bethel CT 06801 fraso@bu.edu Brookline MA 02446  

OBJECTIVE – An entry-level position in Biomedical Engineering with emphasis in biochemistry.

EDUCATION Boston University College of Engineering, Boston, MA Bachelor of Science in Biomedical Engineering, May 2013 Related Coursework: Thermodynamics, Signals and Systems, Controlled Systems, Solid Mechanics, Differential Equations, Neuroengineering, Systems Physiology, Cardiovascular and Respiratory Systems, ECT, Bioinstrumentation, Directed Study in Chemistry, Biomaterials, Biotransport, Nanotechnology

PROJECTS Genetic Modification of Brain Cells Using Non-viral Methods – This research project focused on synthetic

alternatives for gene delivery in a mouse model. The pathway of delivered genes was studied from internalization into a cell using fluorescence in situ hybridization in vitro. A computation method was designed to help automate the analysis of the cell counting, GFP expression and DAB stained images. C-S Bond Formation Catalyzed by non-heme iron enzyme in Ovothiol Biosythesis – After successively cloning, overexpressing and purifying ovoA, this research project focused on the kinetic modeling of ovoA through oxygen consumption. The iron dependence and effects of TCEP, cysteine and histidine on ovoA oxygen consumption was tested as well as the kinetics of apoOvoA. How the Brain Perceives the Acoustic Environment - This experiment examined how well an individual can locate the origin of sound both with and without visual aids at varying azimuth and elevations using an electrooculogram.

Addition Projects: Built basic digital thermometer and pulse oximeter

REVEVANT EXPERIENCE Research Assistant September 2012 – May 2013 Han Group Neuroengineering Lab, Boston University Boston, MA

• Optimized fluorescence in situ hybridization in HEK293 cells • Developed computational method to automate analysis of cell counting, GFP expression and DAB stained images

Research Assistant January 2012 – Present Liu Group Biochemistry Lab, Boston University Boston, MA

• Overexpressed proteins in E. Coli, focusing on ovothiol and cell growth • Purified proteins using various techniques such as Strep-tag (aerobic and anaerobic), DEAE and Hydroxyapatite • Performed oxygen sensitive protein kinetics, Performed iron activity assay, Bradford

Research Assistant Summer 2011 McDonald Group, Einstein Medical Center Bronx, NY

• DNA cloned and transformed into E. Coli • Purified proteins synthesized • DNA mutagenesis

Lab Assistant Summer 2008 JMS Environmental Services, Inc. Danbury, CT.

• Prepared samples and ran various tests on soil and water samples. ADDITIONAL EXPERIENCE Ice cream scooper J.P. Licks Ice Cream and Coffee Shop Summer 2012 – Present

SKILLS Laboratory: Measuring samples, autoclave, Coy Chamber, buffer preparation and degassing, pipetting, gel electrophoresis, DNA and protein preparation, gel extraction, mini, midi and maxi DNA preparation, ECG and EOG setup and computer analysis, ligations, digestion, PCR, spectrometry, Bradford, DNA cloning, isolation and transformation, fluorescent microscopy, fluorescence in situ probe preparation and hybridization, protein purification (anaerobic, aerobic, Strep-tag, DEAE, hydroxyapatite), e. coli cell cultures, eukaryotic cell cultures (HEK), kinetics protein preparation, reactions, and data analysis. Computer Applications: MATLAB, Mathematica, LabView, simple electric circuits, op amps, oscilloscopes, function generator. PUBLICATIONS Submitted scientific paper to Angewante Chemie as second author

OBJECTIVE Obtain a position at a reputable company where I can maximize my skills learned while attending Boston University’s College of Engineering.

EDUCATION Boston University College of Engineering, Boston MABachelor of Science in Biomedical Engineering, May 2013

Carnegie Mellon University College of Engineering, Pittsburgh PAMaster of Science in Biomedical Engineering, May 2015

Relevant Course Work: Signals & Systems in Biomedical Engineering, Computational Biology, Control Systems in BME, Solid Biomechanics, Biomedical Measurements I&II, Thermodynamics, Systems Physiology, Neuroengineering, Biomedical Instrumentation, Project Design & Innovation, Principles of Molecular & Cell Biology, Electric Circuit Theory, DNA Structure and Function, Human Brain Mapping, Stem Cell and Cloning, Eng. Mechanics, Eng. Computation in MatLab, General Chemistry, Organic Chemistry, Physics, Calculus, Differential Equations.

PROJECTS “Visual Detection of Emerging Pathogens” (September 2012-Present) Detecting pathogenic DNA in a way that can be done isothermally in the field and with a high degree of sensitivity. Will improve upon the level of detection from by making use of hyper-branched rolling circle amplification (RCA) and evaluating this level of detection procedure through the detection of E.coli DNA. Will design an oligonucleotide probe that will increase signal amplification capabilities of the RCA products and will test nicking endonucleases and restrictions on the RCA product. Optimum detection reaction conditions will be determined for DNAzymes.

Analyzed the effects of brain perception of the acoustic environment through the analysis of eye movement reactions to auditory cues (from different degrees from center) and the effects of using a visual aid and no visual aid.

SKILLS Laboratory: Gel electrophoresis, cell culture, DNA extraction, PCR, NMR, Infrared Spectroscopy, RCA, DNA ligation, Acrylamide gel, Mass spectrometry, gene expression, centrifugation, solution preparation, buffer preparation, electrocardiogram and electrooculogram readings, oscilloscope, function generator, iWorx, basic circuit building.

Computer: MatLab, Microsoft Word, Microsoft Publisher, Microsoft Excel, Microsoft Outlook.

EXPERIENCE Research Assistant Boston, MA COMBREX (at Boston University) May 2010-August 2012

• Identify the threshold at which functional propagation was retained accurately • Examine the similarity of “gold” proteins to other “gold” proteins and compared

their annotations at various e-values and manually annotated proteins

Assistant to Warehouse and Production Scheduler Bedford, NH Graham Packaging PET Technologies May 2012-September 2012

Figure Skating Coach Boston, MA & Nashua, NH Walter Brown Arena September 2011-Present Conway Arena November 2005-September 2009 ACTIVITIES: BU Figure Skating Club 2009-Present, BU Hunger Relief member since 2011, Sigma Alpha Lambda Honors Society member since 2010, Community Service Center member since 2009.

School Address Krista Rochussen Permanent Address10 Buick Street Apt. 1507 kristar@bu.edu 10 Chatfield DriveBoston MA 02215 (603) 289-6187 Litchfield NH 03052

JENNIFER M. RYAN 31 Ridgewood Dr., Trophy Club, TX 76262 ⋄ jryan51@bu.edu ⋄ 940-368-6492

EDUCATION Boston University, College of Engineering, Boston, MA Bachelor of Science in Biomedical Engineering, May 2013 Engineering Scholar Dean’s List

EXPERIENCE Research Assistant 2012 - present Matrix Mechanotransduction Laboratory Boston, MA

• Devise a method to insert a fluorescent micropatterned hydrogel with cultured endothelial cells into a parallel plate chamber

• Use microscopy techniques to image cell deformations due to fluid shear stress and cellular contractile forces

• Measure traction forces of cultured endothelial cells in the presence of fluid flow

Research Assistant 2010 - 2011 Neuromuscular Research Center Boston, MA

• Collect video and sensor data from Parkinson’s disease (PD) patients for project aimed at creating a wearable sensor system for PD patients in order to monitor their movement disorders

• Identify and record the occurrences and severity of specific neuromuscular movement disorders, such as tremor and dyskinesia, in patients with PD from video data

• Received UROP funding (Clare Boothe Luce Scholar - Summer 2011)

ACTIVITIES Volunteer, Brigham and Women’s Hospital, Boston, MA College of Engineering Dean’s Host, Boston University, Boston, MA Community Advisor for Summer Orientation, Boston University, Boston, MA SAT Math tutor for Let’s Get Ready, Boston, MA Social Committee Chair for Boston University Catholic Center, Boston, MA Producer of Women’s Retreat for BU Catholic Center, Boston, MA Target House Volunteer, St. Jude Children’s Research Hospital, Memphis, TN Mentor in DREAM Program, Boston University, Boston, MA

SKILLS Laboratory: Nuclear magnetic resonance spectroscopy, Infrared spectroscopy, Thin layer chromatography, Gas chromatography, Microscopy, Polymerase chain reaction, Gel electrophoresis Computer: MATLAB, Microsoft Office, Mathematica, ImageJ, Labview, MathCad

RALPH SAYAD 91 Linden Street apt 2 Allston, MA -02134

(973) 444-2151 sayad28@bu.edu

EDUCATION Boston University College of Engineering Boston, MA Candidate for a Bachelor of Science in Biomedical Engineering 09/2009 to 05/2013 Cumulative GPA : 3.92/4.00 Expected Graduation : May 2013 EXPERIENCE Capital Trust Downtown Beirut, Lebanon Private equity firm Intern, Financial Analyst, Full-Time Position 06/2011 to 07/2011 Assisted in the sourcing, initial screening and execution of potential investment opportunities. Exposed on how to build complex financial models to analyze investment returns and conduct various valuation

analyses (e.g. DCF, Transaction Comparables, Public Comparables). Performed industry and company-specific research and analysis in support of the investment idea generation process

and the evaluation of new investment opportunities. Drafted internal memoranda and investment process materials. Boston University Boston, MA Grader / Teacher Assistant, Part-Time Position 01/2011 to 05/2011 Grader for Linear Algebra PROJECTS

Performed the financial analysis for a fictive company, Digistyle whose main product is a virtual dressing room. Performed cost analysis to find total investment needed, and generated cash flows to find breakeven point, payback period and IRR.

Signal acquisition and display, data sampling (Labview, sampling rate), sensor and signal conditioning ( ECG, amplification, filtering and triggered averaging), system modeling and design ( oculomotor system, Fourier analysis, frequency response); research project on voice recognition algorithms

Assisted Dr. Bryan Hudson, Ph.D., HSPP, Chairperson of Telehealth/Telemedicine for the National PABI Act (HR 2600) and also serves on the Executive Steering Committee of the Sarah Jane Brain Project, as well as the MedScape and WebMD Steering Committee on Pediatric Acquired Brain Injury, and Dr. Stephanie Peabody, Psy.D, HSPP Visiting Scholar, Harvard Graduate School of Education in their project/research to enhance CNS central nervous system health worldwide by improving the delivery and outcomes of CNS treatment, while simultaneously decreasing the cost and inefficiency of healthcare delivery. Their desire is to greatly increase the collection and accessibility of pertinent medical data for purposes of research, education, training, and discovery.[06/04/2012-08/10/2012]

HIGHLIGHTED SKILLS Very strong analytical skills and problem solving background. Experience in modeling systems and merging computational techniques to problem solving. Good leadership and communication skills Multi-cultural background. Fluent in three languages (Arabic, French and English). Proficient with C++, MATLAB, Java, Sigma Plot, ImageJ, Labview and MS Excel. PROFESSIONAL ASSOCIATIONS AND AWARDS Member of Tau Beta Pi Engineering Honor Society as of January 2012. Dean’s List Student : Fall 2009, Spring 2010, Fall 2010, Spring 2011, Fall 2011, Spring 2012, Fall 2012 French Baccalaureate diploma, June 2009 session (mathematics specialty, Mention Bien Honor)

MEGHAN SCHREINER 48 Brighton Ave, Apt 15, Allston, MA 02134 716-462-3331 mschrein@bu.edu

OBJECTIVE Obtain a permanent position at a reputable company where I can maximize my engineering and critical thinking skills learned while attending Boston University’s College of Engineering. EDUCATION Boston University College of Engineering, Boston MA Bachelor of Science in Biomedical Engineering May 2013 Dean’s List Fall 2012 Related Course Work: Signals & Systems in Biomedical Engineering, Intro to Neuroengineering, DNA Structure & Function, Biomedical Instrumentation, Quantitative Physiology of Auditory Systems, Computational Biology, Intro to Computational Vision, Control Systems in BME, Solid Biomechanics, Biomedical Measurements I&II, Thermodynamics, Systems Physiology, Project Design & Innovation, Principles of Molecular & Cell Biology, Electric Circuit Theory, Human Brain Mapping, Biomedical Eng. Environments, Eng. Mechanics, Eng. Computation in MatLab, Differential Equations. PROJECTS Senior Project: “Visual Detection of Emerging Pathogens,” (9/2012-present)

• Detected pathogenic DNA in a way that can be done isothermally in the field and with a high degree of sensitivity. • Improved upon the level of detection from previous projects by making use of hyper branched rolling circle

amplification (RCA) and evaluating this level of detection procedure through the detection of E. coli DNA. • Designed an oligonucleotide probe that increased signal amplification capabilities of the RCA products and tested the

nicking endonucleases and restrictions on the RCA product. • Optimum detection reaction conditions were determined for the DNAzymes.

Biomedical Measurements Project: “Effects of Melatonin and Taurine Based Beverage on Heart Rate, Eye Movement Reaction Times, and Maximum Muscle Contraction,” (10/2011-12/2011)

• Analyzed the effects of various Melatonin and Taurine based drinks through the analysis of heart rate from an electrocardiogram, eye movement reaction times from an electrooculogram, and maximum muscle contraction voltage from an electromyography.

SKILLS Laboratory: Gel electrophoresis, cell culture, DNA extraction, PCR, RCA, mass spectrometry, gene expression, basic solution preparation, buffer preparation, iWorx, basic circuit building, Circle Ligation, acrylamide and agarose gel preparation. Computer: MatLab, LabView, Microsoft Word, Microsoft PowerPoint, Microsoft Excel, Microsoft Outlook, SalesForce.com EXPERIENCE Internship October 2011- August 2012 Scientia Advisors, LLC Cambridge, MA

• Developed an organizational structure for key accounts with a supporting glossary • Researched and imported relevant information pertaining to key accounts (both US and EU) • Designed and advised on implementation of a dedicated section that house the key account within

ScientiaNET Work Study May 2011- Present BU College of Engineering Career Development Office Boston, MA

• Answer phone calls from students and employers • Set up appointments for advisors • Post jobs and update the CareerLink • Greet students, faculty, and employers • Manage email account and office spreadsheets

ACTIVITIES BU Rugby Club 2009, Biomedical Engineering Society (BMES) member since 2011

Matthew Scott 447 Park Drive 1B Boston, MA 02215 978 793 3230 matt86@bu.edu OBJECTIVE

Detail oriented engineering student, skilled in design and programming, seeking challenging career opportunities related to computational biology, bioinformatics, or software development

EDUCATION Boston University Boston, MA Bachelor of Science Biomedical Engineering May 2013 GPA: 3.50 Dean's List Spring 2012 Dean’s List Fall 2012 Quinsigamond Community College Worcester, MA Associate of Science Biomedical Engineering May 2011 GPA: 3.94 Worked 40 hours per week in order to finance 75% of education PROJECTS Time-Lapse Imaging of Mycobacteria Boston University Spring 2013-Present

• Modified MicrobeTracker code to include additional fluorescence image • Modified parameters and algorithms to better segregate mycobacterial cells • MicrobeTracker UI modifications

Microfluidic Device for Thyroid Cancer Diagnosis Boston University Fall 2012/Spring 2013 • Ion-exchange column, and experimental, protein purification and extraction from cell lysate • SDS-PAGE • Western Blot

Protein folding Algorithm Boston University Fall 2012 • Developed Matlab code for simulating two-dimensional folding of simplified protein • Completed in one week

LPC Vocoder Boston University Spring 2012 • Developed Matlab code for reducing speech waveform to a small collection of properties • Developed Matlab code to recombine properties into speech waveform • Presented approach and results

Electro-oculogram Controlled Computer Cursor Boston University Fall 2011 • Coordinated distribution of responsibilities • Solely responsible for design and implementation of differentiating amplifier • Aided in design of program in MatLab

EXPERIENCE Product Management Intern Solidworks Waltham, MA May – August 2012

• Researched competitors and new technologies to suggest product improvements • Created and conducted customer surveys to determine product shortcomings • Attended meetings with potential partners to help evaluate offerings for implementation in the

next product version Founder/President Scott Design Bolton, MA 2008-2011

• Drafted field drawings with details of building structure • Drafted component details necessary for installation of glass products • Maintained customers by providing high quality service and prospecting

SKILLS Computer: Matlab, C++, AutoCAD, ProEngineer, CATIA, ImageJ, Sigmaplot, Solidworks Lab: Microscopy, Pipetting, SDS-PAGE, Circuit Design, Oscilloscope, Western Blot ACTIVITIES: Phi Theta Kappa, AMATYC, Biomedical Engineering Society, Dean's host, Engineering Club, Robotics Club

Hussan Shareef hshareef@bu.edu

774-210-2954

1148 Commonwealth Ave. #42 Allston, MA 02134

OBJECTIVE: Seeking an entry-level position in an engineering field. EDUCATION: Boston University, College of Engineering, Boston, MA, USA Bachelors of Science in Biomedical Engineering May 2013 GPA: 3.14 RESEARCH EXPERIENCE Biomedical Optics Lab - Boston University Research Associate Sept. 2012 – Present Worked with a team to develop a device to access cancer cell morphology using scattered light. Designed parts needed for system using SolidWorks. Machined parts needed. Developed software to interpret scattered light patterns. Cultured cells for testing purposes. Presented team’s progress in weekly meetings. RELATED PROJECTS Boston University – Pharmacological Study Sept. 2011 – Dec. 2011 Measured the effects of melatonin and taurine on physiological parameters. Analyzed signals recorded from electrocardiograms, electromyograms and electrooculograms. Tested for significance on acquired data. Electrical Wiring Project Summer 2011 Designed and installed the electrical circuitry for newly constructed house. Assessed and complied with local electrical codes. SKILLS: Proficient in Matlab, Java, and C++. Novice level of Solidworks. Excellent word processing and spreadsheet skills. Experience with LabView. WORK EXPERIENCE Boston University, Boston, MA Mechanics of Materials (ME305) Quiz Grader Sept 2012 – Dec 2012 Graded weekly quizzes of students taking course. Provided feedback on how to approach and solve problems. Ingalls Engineering Resource Center Monitor Sept. 2011 – Jan 2012 Monitored daily operations of center. Troubleshot electronics such as computers, printers and projectors.

ANNA CRISTINA SHIVERS Permanent Address shivers@bu.edu Current Address

725 Redman Ave. 609.410.1163 33 Harry Agganis Way

Haddonfield, NJ 08033 Box 9782

Boston, MA 02215

OBJECTIVE Entry level engineer seeking opportunities in the development or application of medical devices

and pharmaceuticals.

EDUCATION Boston University College of Engineering, Boston, MA

Bachelor of Science in Biomedical Engineering May 2013 (Exp.)

GPA: 3.07/4.0 ; Dean’s List (1 Semester)

Technische Universität Dresden (Semester-long Study Abroad Program in Dresden, Germany) Spring 2011

Relevant Coursework: Medical Imaging, Thermodynamics, Biomed. Product Design, Nanomaterial/Technology, Material

Science, CAD and Machine Components, Intro. Continuum Mechanics, Engineering Mechanics, Biomedical Measurements,

Systems Physiology, Molecular Biology, Matlab.

PROJECTS

• Biomedical Engineering Senior Design Project- using ultrasound contrast agents as theranostic agents to

simultaneously detect and treat atherosclerosis affected tissue noninvasively.

• Biomedical Product Design and Innovation- Group picked a current Medical Device and learned the process of

medical device development. A project plan is developed and proposed as if the group were the inventing engineers.

• Biomedical Measurements – Group designed an ‘Electronic Stethoscope’ that would pick up the heart sounds and

displays them on an oscilloscope. Designed a cone for the microphone in order to amplify the sounds and determined

methodology of applying it to different regions of the around the heart to hear either the ‘lub’ or ‘dub’ better.

• Design and Manufacture Project -- Collaborated with another student to conceive and construct a BU Alumni domino

box set from Acrylic plastics; used SolidWorks for designing and GibbsCam with manufacturing machinery for

production.

• Material Processing and Product Development -- Designed a clock on ArtCAM and then machined a mold

used for casting the clock. Cut, bent and welded stand to hold the clock in two positions.

• Truss Project --Worked with group to design, construct and test strength of truss bridge in accordance with

specified dimensions, materials, and cost requirements.

EXPERIENCE Boston University, Biomimetic Materials Engineering Lab, Research Assistant Spring 2012- Present

• Part of a group researching theranostic microbubbles as targeted chemotherapy drug delivery system

• Designed a flow chamber using SolidWorks for a hydrogel mold to hold the microbubbles for testing under

ultrasound. Tested microfluidic device’s ability to make double emulsion microbubbles and designed alterations of

the device to improve production. Experimentally tested combinations of oil, lipid, and gas composition to find best

combination.

Boston University, Mechanical Engineering Dept. Research Assistant Spring 2010-Spring 2011

• Participated in independent research dealing with the effect of shock waves on the healing of a bone.

• Analyzed the growth and collapse of bubbles on a rat bone using Matlab.

SKILLS Computer: Matlab, Solidworks, MathCad, ImageJ, Microsoft Office

Wet Lab: Ultrasound Imaging (Analogics), Tip Sonicator, Bath Sonicator, passaging cells, microfluidic production

ACTIVITIES AND LEADERSHIP

Member, Society of Women Engineers at BU Fall 2009-Present

• President (Fall 2012- Present), Vice President (Fall 2011 – Spring 2012) and Secretary (Fall 2010 - Spring 2011).

Boston University Deans Host Fall 2011-Present

• Represent the College of Engineering at formal functions including Open House and Commencement.

• Conduct campus tours for prospective students.

Participant, Hartford Half Marathon Fall 2012

Participant, Outward Bound Wilderness Experience Summer 2008

Ashley Stein 6215  Coyote  Point  Ct.  Reno,  NV  89511  

 ashleygs282@gmail.com  (775)  745  7229    

           Education                 Boston  University,  Boston,  MA                                        May,  2013  

    Bachelor  of  Science  in  Biomedical  Engineering        Professional  Experience  

Zephyr  Photonics,  Zephyr  Cove,  NV                    Electrical  Engineering  Internship                                                                                                                                                                                                                              May  2012  –  August  2012  

• Created  and  performed  a  DOE  to  characterize  mesas  on  a  wafer  due  to  different  photoresists,  exposure  times,  bake  times,  and  development  times.  Ultimately  I  was  able  to  characterize  the  resists  and  processes  of  making  a  wafer,  helpful  to  those  who  write  the  processes.  

• Designed  two  LabView  programs:  (1)  to  sweep  through  wavelengths  of  a  tunable  laser  and  collect  voltage  and  current  from  each  device  on  a  wafer  and  (2)  to  sweep  through  current  of  a  sourcemeter  and  collect  currents  from  both  the  function  generator  and  picoammeter  of  each  device  on  a  wafer,  both  at  different  temperatures.    These  programs  simplified  and  increased  the  efficiency  of  a  previously  lengthy  and  tedious  procedure.  

Skills  Instrumentation

Oscilloscope,  Function  Generator,  Picoammeter,  tunable  laser,  Spirometer,  ECG,  EMG,  EOG,  Spectrophotometer,  Compound  Microscope,  Ultra  Sound,  Axic  HF-­‐8  Multimode  Descummer,  UFT-­‐620  CEE  Spinner,  MA/BA6  Mask  Aligner,  Scanning  Electron  Microscope,  Denton  Vacuum  Desk  II  Sputterer,  Plasma  Enhanced  Chemical  Vapor  Deposition  (PECVD),  Reactive  Ion  Etching  (RIE)  

Software MATLAB,  MATHCAD,  Lab  View,  JMP,  Lab  Scribe,  ImageJ,  Sigma  Plot,  Microsoft  Office,  Mac  OS/Windows/  Linux  operating  

systems  Processes  

PCR,  Gel  Electrophoresis,  TLC,  Column  Chromatography,  Gas  Chromatography/Reflux/Distillation,  IR  and  NMR  Spectroscopy,  Gram  Staining,  Tensile  &  Hysteresis  Tests,  DOE  

Projects  Truss  Design  (2011)  

    -­‐  Designed  MATLAB  program  to  test  and  help  build  a  truss  to  hold  a  maximum  load.  Molecular  Cloning  (2011)  

-­‐  Techniques  such  as  ligation,  electrophoresis,  and  PCR  were  utilized  to  amplify,  isolate,  and  identify  a  mystery  promoter  for  a  given  gene  in  a  cell.  

How  the  Brain  Perceives  the  Acoustic  Environment  (2011)  -­‐ Created  a  MATLAB  program  to  test  auditory  stimuli  with  visual  cues  to  see  whether  people  with  visual  impairment  can  identify  the  source  of  a  sound  in  space.    

Design  and  Development  of  Fast  MRI  pulse  sequence  for  Quantification  of  Iron  Tissue  (2012-­‐2013)  -­‐ Designed  a  hybrid  pulse  sequence  using  Turbo  Spin  Echo  and  Gradient  Spin  Echo  fast  pulse  sequences  to  improve  the  Hepatic  Iron  Concentration  (HIC)  range  in  MRI  images.  -­‐ Fabricated  a  phantom  made  of  agarose  gel  with  various  iron  concentrations    

Desgin  of  Central  Line  (2013)  -­‐ Designed  an  ultrasound  transducer  with  a  pressure-­‐sensing  needle  to  simultaneously  detect  the  location  of,  and  confirm  needle  placement  within,  a  vein  to  improve  the  precision  of  central  line  placement.  

Related  Coursework  Electronic  Circuitry     Fluid  Mechanics   General  &  Organic  Chemistry  Signals  and  Systems     Biomedical  &Biological  Measurements   Cell  Biology  &  Systems  Physiology    Control  Systems   Human  Brain  Mapping   Neuroengineering    Physics   Auditory  Systems/  Hearing  Prosthetics   DNA  Structure  &  Function  Probability/Statistics   Product  Design  &  Development                  Thermodynamics  

 Activities  &  Achievements  

  Black  Belt  in  Taekwondo,  Massachusetts  Collegiate  Taekwondo            April  2013  National  Society  of  Collegiate  Scholars  (NSCS)   2009-­‐present  

  Boston  University  Dean’s  Scholarship     2009-­‐2012  Studied  abroad  in  Padova,  Italy     September  –  December  2010  

Elaine Steranka (408) 398-5445 • elaines@bu.edu

Present Address: Permanent Address:

10 Buick Street, PO BOX 8322 7086 O'Grady Dr.

Boston, MA 02215 San Jose, CA 95120

EDUCATION Boston University College of Engineering, Boston, MA

Bachelor of Science, Biomedical Engineering May 2013 May 2013

Technische Universität Dresden, Dresden, Germany Spring 2011

Studied abroad for six months while taking 20 credits.

Awards: Poster Presentation at BMES Conference October 2012

UROP Student Research Award Recipient Summer 2012

Research title: "Lipid-Polymer Hybrid Nanoparticles for Sustained Delivery of Doxorubicin"

Relevant Coursework: Business Technology Innovation, Biomolecular architecture, Biotransport, Medical

Imaging, Product Design, Fluid Mechanics, Electric Circuit Theory, Engineering Mechanics,

Thermodynamics, Signals & Systems, Human Physiology, Computational Vision, Differential Equations.

WORK EXPERIENCE BU Nanomedicine & Medical Acoustics Lab, Boston, MA October 2012 – Current

Research Assistant—Senior Project

Working to stop progression of atherosclerosis by knocking down expression of vascular adhesion

molecule-1 using siRNA.

Target delivery of siRNA by binding polymer nanoparticles to lipid coated microbubbles.

Developed a nanoparticle carrier to increase drug circulation time and reduce toxicity.

Used ultrasound contrast agents for non-invasive and targeted intracellular delivery.

BU Nanomedicine & Medical Acoustics Lab, Boston, MA October 2011 – September 2012

Research Assistant

Made a lipid-polymer hybrid nanoparticle carrier to encapsulate and deliver a therapeutic drug.

Targeted delivery of the nanoparticles to cancer cells using folic acid/folate receptor binding.

Cytotoxicity and uptake of the nanoparticles were tested against KB cell lines.

Good Samaritan Hospital, San Jose, CA December 2005 – March 2009

Patient Services Volunteer

Helped deliver pharmacy prescriptions, discharged & assisted patients, worked information desk.

ENGINEERING PROJECTS Coronary Stent Product Development Fall 2012

Made a product development plan for patenting and marketing a Boston Scientific coronary stent.

Voice Recognition Program Fall 2011 Fall 2011 Worked in a group to create a program that could identify users by voice using MATLAB.

Analyzed frequency signals of recorded words from different individuals to determine most

effective way to identify a variety of voices.

SKILLS Cell culture, dynamic light scattering machine, ultrasonic probe, lyophilizing, micropipetting.

Microsoft Word, Excel, PowerPoint, Photoshop, MATLAB, Adobe Illustrator.

LEADERSHIP Society of Women Engineers, Boston, MA

Vice President 2012-2013

Junior Representative 2011-2012

Member of Biomedical Engineering Society Fall 2011-Current

Deans Host for BU College of Engineering January 2009-Current

Dylan Stevens 1 McNab Court Bridgewater, NJ 08807

(908) 720-7429 – dylan.v.stevens@gmail.com

Education: Boston University School of Engineering GPA: 3.63

Senior - working towards a BS in Biomedical Engineering/Pre-Med Bridgewater Raritan Regional High School Graduated 2009

Work Experience: Research Assistant Boston, MA June 2012 - present

Assisted Dr. Betty Galarretta with biosensing research in Professor Hatice Altug’s lab

Trained and certified on SensiQ® Pioneer SPR machine

Worked with VSV virus and functionalization in Dr. John Connor’s lab at Boston University School of Medicine

Engineering Inspector Franklin, NJ June-August 2011

Oversaw construction on a variety of sites and used civil engineering techniques to ensure quality construction

Analyzed proposed plans to ensure construction was within safety/building constraints of Franklin Township

Aided in the training of other summer interns

Summer Custodial Help Bridgewater, NJ July-August 2006-2009

Waxed floors, moved furniture, and provided general cleaning services for school buildings

Awards & Activities: Received Dean’s List honors for 6 semesters

Grant recipient from Boston University for 4 years

Pianist in Boston University jazz band (Big Band and Jazz Workshop) 2009-2011

Member of Boston University Biomedical Engineering Society 2009-

Secretary of Boston University Jazz Appreciators and Musicians Club 2012-

Alpha Eta Mu Beta member (Biomedical Engineering Honor Society) Fall 2012-

Tau Beta Pi member (Engineering Honors Society) Fall 2012-

Volunteer undergraduate assistant in Human Physiology under Dr. Angela Seliga 2012 o Aided in teaching undergraduates lab techniques and tech use

Volunteer research assistant to Dr. Wolpert at Joslin Diabetes Center February 2013-

Skills: Skilled with computers: Microsoft Office, MATLAB, Python

Strong skills across sciences/math

Teaching experience (training of other inspectors, and lab with Dr. Seliga)

Benjamin S. Szewczyk Mobile: (978) 621-1292; Email: szewczyk@bu.edu

Permanent Address: 20 Mohawk Drive Acton, MA 01720

Education

Boston University Graduation: May 2013

Candidate for Bachelors of Science in Biomedical Engineering

Albany Medical College Graduation: May 2017

Work and Volunteer Experience

Boston University Residence Life Boston, MA

Resident Assistant (RA) Fall 2012 – Present

Oversee the Engineering House, serve on-call needs of the residents, and complete

general rounds on campus.

Beth Israel Medical Deaconess Boston, MA

Volunteer Summer 2012 – Fall 2012

Assisted in the Post-Operative Care Unit.

Boston University Medical School Cancer Research Center Boston, MA

Research Assistant- Volunteer Fall 2011- Spring 2012

Experiment: Investigating the inhibition of Brd2 as a novel anti-inflammatory

strategy in treating Type 2 diabetes.

Newton Wellesley Hospital Newton, MA

Technical Lab Assistant – Microbiology Department Summer 2010- Present

Aid in planting specimens (tissue, spinal fluid, general fluids,

and aerobic/anaerobic swabs), sets up herpes cultures and ova and parasite tests.

Macy’s Natick, MA

Sales Associate Summer 2010

Provided outstanding customer service.

Boston University Chemistry Department Boston, MA

Laboratory Assistant Fall 2009- Spring 2011

Work study, assisted in laboratory experiment preparation and stock room duties.

Industrial Designs Acton, MA

Construction Worker and Personal Assistant Summer 2009- Winter 2010

Aided in construction and repair of playground structures.

Leadership Experience

Tau Beta Pi Engineering Honors Society Summer 2012-Present

President- Organize meetings, events, and complete necessary paperwork.

Boston University Undergraduate Assistant (UA) Spring 2011

Biology 2 (BI108)- Led demonstrations and answered questions during lab periods.

Acton Boxborough Regional High School Marching Colonials Fall 2008- Spring 2009

Drum Major- Led marching drills and conducted the band during half-time shows.

Boy Scouts of America Fall 1999- Spring 2009

Eagle Scout, Troop 32- Highest rank in BSA.

Achievements and Involvement

Alpha Eta Mu Beta Biomedical Engineering Honors Society Spring 2012- Present

Alpha Epsilon Delta Pre-Health Honors Society Spring 2012- Present

Tau Beta Pi Engineering Honors Society Fall 2011- Present

Massachusetts Collegiate Tae Kwon Do Association Fall 2010- Spring 2013

Boston University Ping Pong Club Fall 2009- Spring 2010

Boy Scouts of America- Troop 32, Acton MA Fall 1999- Spring 2009

Awards and Scholarships

Waxer Memorial Fund

Excellence in Engineering Book Award

Computer Skills:

Matlab, SolidWorks, Microsoft Office, LabVIEW, LabScribe, Verilog

Chun Hin Dicky Tang 28 Hopedale St., Allston, MA 02134 dctang@bu.edu 857-334-8144

OBJECTIVE An entry-level position in Biomedical Engineering or an internship in Engineering, preferably in Biomedical Engineering

EDUCATION Boston University College of Engineering, Boston, MA Bachelor of Science in Biomedical Engineering, May 2013 GPA: 3.12/4.00

Relevant Coursework: Calc. 1-4, Gen. Chem. 1&2, Organic Chem. 1&2, Physics 1&2, Mechanics, Fluid Mech., Electric Circuit Theory, Electronics, Thermodynamics, Cell Bio. & Biotech., Sys. Physiology, Signals & Sys., Control Sys., Biomaterials, Nanomaterials & Nanotech., Tissue Eng., Neuroengineering

PROJECTS Senior Design Project (Optimization for the Immobilization of Biotin): Optimize the treatment of a cyclic polyolefin (COP) surface for the immobilization of biotin. Using oxygen-plasma treatment and chromic acid treatment the surface chemistry of the COP is changed from being hydrophobic to hydrophilic. To quantify how hydrophilic the surface is, the contact angle is measured. The optimal treatment length will yield the most hydrophilic surface and allow for the situation for the immobilization of biotin. Fluorecein conjugated streptavidin are coupled to the biotin and using a fluorescent microscope the amount of biotin immobilization can be indirectly quantified from the fluorescent signal. Additional Projects (Mice Spatial Memory Testing): Developed a MATLAB program that controls a touch screen, infrared sensor, water pump, buzzer, LED and LED strip which are all used for the mice spatial memory testing. Built the box used for training/testing the mice. Wired the entire setup and designed the circuits necessary to power the water pump, LED light and light strip and infrared sensor. The MATLAB program was used to control the 6 stages of the mice spatial memory test. The first three stages are used to get the mice accustomed to the box, the touchscreen, the buzzer sound, the LED lights and triggering the sensor. The last three stages are used to test the mice spatial memory. The goal of the experiment is to compare the results of the spatial memory tests for normal lab mice and mice that are enhanced with optogenetics. The end goal is using optogenetics to improve memory of Alzheimer's patient.

SKILLS Laboratory: Chromatography, ultra violet spectrometer, gel electrophoresis, cell culture, antibody staining, southern blot, infrared spectrometer, PCR, plasma treatment, spectrometer, microscope, hot press Computer Applications: MATLAB, Cadence, ImageJ, SpectraSuite, MetaMorph Advanced, SolidWorks, Microsoft Office, Drop Shape Analysis

EXPERIENCE Research Assistant: June 2011 – September 2011 Biomedical/Neuroscience Laboratory, Boston University Boston, MA MATLAB programming, Circuit design, building mice training box Mice Spatial Memory Testing project (refer to additional projects)

Volunteer Work: Greater Boston Food Bank January 2010 – Present Weighing/quality control of the organized boxes of items

ACTIVITIES & Martial Arts and Lion Dance which includes occasion performances for INTEREST the general public and for special events. Since: 2006

Kristian Thomas 5 Diellen Court Commack NY 11725

kristhom@bu.edu (631)836-9123

Objective To pursue an internship or opportunity in a medical device firm where I can utilize my engineering skills

Education

M.Eng, Biomedical Engineering

B.S, Biomedical Engineering with a Minor in Electrical Engineering Relevant Coursework:

Signals and Systems Control Systems Tissue Engineering Business of Technology Innovation Product Design and Innovation Senior Capstone Device and Diagnostic Design Biomedical Measurements Software Engineering

Work Experience

Research Assistant

Studying psycho-acoustical features to improve diagnostic hearing tests for impaired listeners

Recording and analyzing conversations in everyday listening situations to create speech intelligibility tests

Presented research at the 2012 BMES National Conference in Atlanta, GA

Basis of Senior Capstone

Transportation Construction Inspector

Performed gradations and other soil tests

Responsibilities included on-site concrete inspection, earthwork inspection, asphalt pavement inspection, and other miscellaneous inspection assignments

Projects

Project for Product Design and Innovation with a group of that consisted of 4 members

Prepared a development plan for a Medtronic Talent Converter Abdominal Stent Graft as if it hasn’t been introduced to the market

Needed to follow all FDA regulations that a medical device would go through

Project for Business of Technology Innovation with a group that consisted of 5 members

Designed a faucet that would force people to wash their hands thoroughly

Produced a business plan for the product

Project for Biomedical Measurements with a group of that consisted of 5 members

Designed a device that would monitor the user’s pulse during a workout session so as to maximize their quality of exercise

Technical Skills: C, C++, Image J, MathCad, MATLAB, Microsoft Office, LaTeX, and Pratt

Cornell University, Ithaca, NY May 2014

Boston University, Boston, MA May 2013

Hearing Research Center, Boston, MA February 2012 - Present

New York State Department of Transportation, Hauppauge, NY Summer 2010, 2011

Medtronic Talent Converter Abdominal Stent Graft Fall 2012

Clean Hands, for a Clean Healthy Life Spring 2012

Auditory Heart Monitoring Aid Fall 2011

Activities

Vice President of the Biomedical Engineering Society

Boston University College of Engineering Dean’s Host

Boston University India Club

Skills

ROBERT M. TONA

8 Zev Court, Monmouth Junction, NJ 08852 908-616-3828 bobtona@bu.edu

EDUCATION Boston University, College of Engineering, Boston, MA Bachelor of Science, Biomedical Engineering Class of 2013 GPA 3.52 Tel Aviv University, Tel Aviv, Israel Engineering Study Abroad Spring 2011 Related Coursework Organic Chemistry, Signals and Systems, Thermodynamics, Product Design, Control Systems, Biotransport, Biomedical Measurements, Software Engineering (C++), Solid Biomechanics, Biomaterials, Tissue Engineering, Neuroengineering RESEARCH Senior Design Project: “Creating Virtual Environments by Recording and Analyzing Typical Everyday Listening Situations”

Recorded speech on an acoustical mannequin KEMAR in real-life noise environments (e.g. restaurant, study lounge, street, intersection, and on the T) in order to create virtual listening environments. These environments were used to create a variety of tests for the hearing impaired.

Tested for speech intelligibility included binaural speech interpretation in real-life noise.

Design project with one other partner. Responsibilities included testing equipment, recording real-life noise, creating virtual listening environments with Matlab, creating GUI for the final hearing test, and running tests on subjects.

Subjects were instructed to find a threshold where they could understand roughly half of the words spoken against a variety of background noise. These thresholds were verified by instructing subjects to list spoken words heard in short conversations at these previously selected thresholds.

Summer Intern at the MIRTHE Center (Mid-Infrared Technologies for Health and the Environment) at Princeton University Project: “In Vivo Mid-Infrared Light Reflection Studies for Glucose Monitoring” Summer 2012

Investigated the effects of mid-infrared laser light on interstitial glucose concentrations using a Quantum Cascade (QC) laser.

Designed an optical setup to measure QC laser light reflection off the forearms of subjects during various tasks (i.e. holding breath, voluntary apnea, writing, etc.) in hopes of detecting changes in glucose concentration.

Presented work (presentation and poster) at the MIRTHE summer conference at UMBC. (Abstract: www.mirthecenter.org) PROJECTS

Group product design simulation on the innovation of Medtronic Vascular Talent Thoracic Stent Graft System.

Fall 2012

Group project creating a basic TicTacToe game for android.

Several projects on auditory responses for sounds in anechoic space (Matlab). Examined HRTFs from different subjects and how frequency spectrums are affected by interaural differences caused by size and shape of the head, torso, and pinnae.

Fall 2012 Fall 2011

Group project creating an auditory heart rate monitor using ECG electrodes and a team made program.

Fall 2011

HONORS AND ACTIVITIES

Member of Alpha Eta Mu Beta (AEMB) National Biomedical Engineering Honors Society

Member of Tau Beta Pi (TBP) National Engineering Honors Society

Member of BMES Biomedical Engineering Society

Dean’s List 5 consecutive semesters

Chemistry Stock Room Assistant

Little League Baseball Umpire (SBAA) & Camp Councilor (Spring & Summer 2006,2007,2008)

Experience using Matlab, C++

Certified EMT-B in the state of New Jersey

JEANNE TRAN

School Address Permanent Address 208 Bay State Road 24 Pearl Street

Boston, MA 02215 Boston, MA 02125

617.710.7251 jeanne.h.tran@gmail.com __________________________________________________________________________________________________________________________________________________________

OBJECTIVE A passionate and innovative engineer seeking a challenging, full-time position at a

dynamic biotech company.

EDUCATION Boston University College of Engineering, Boston, MA

Bachelor of Science in Biomedical Engineering, May 2013

Nanotechnology Concentration

Relevant Coursework: Nanometer Scale Processes in Living Systems, Principles and

Applications of Tissue Engineering, Molecular Bioengineering, Intro to

Nanomaterials/Nanotechnology

SKILLS MATLAB, ImageJ, Microfluidics, RCA, PCR, Cell culture, gel electrophoresis, bacterial

DNA extraction, wetlab

Fluent in Vietnamese

RELEVANT Research Assistant Fall 2012 - Present EXPERIENCE Molecular Biotechnology Research Laboratory Boston University

Senior Project: Developing portable thermoplastic devices that use novel DNA

amplification technology to filter and separate nucleic acids for diagnosing hard-to-

detect diseases.

Treat microfluidic channels with plasma-oxygen on the microscale and nanoscale

levels.

Summer 2009 Jackson-Grusby Laboratory Children’s Hospital

Performed DNA Methylation of DNMT1 on mouse cells in order to research the

effects of cell function, DNA methylation activity and DNMT1 protein production and

protein-protein interaction in a cell when DMNT1 is mutated.

ADDITIONAL Media Assistant Fall 2012 - present EXPERIENCE BU Law Systems and Technology Boston, MA

Generic communications media assistant; set up media center for speaker events and

assist with basic computer troubleshooting.

Office Assistant (Work Study) Fall 2010 - Spring 2011 BU Claflin Hall Residence Office Boston, MA

Provide clerical and secretarial support to students and parents

VOLUNTEER MCEP (Medical Careers Exploration Program) Spring 2011- present Brigham and Women’s Hospital Boston, MA

NICU front desk security and caretaker for premature newborn infants

MEMBERSHIP Biomedical Engineering Society (BMES), member since 2013

Boston University Pianist Association, member since 2009

BU Vietnamese Student Association, member since 2009

ANJANESH VENKATESH 94  Holland  Woods  Road  Leominster,  MA  01453  978.870.5997    anjanv@bu.edu    EDUCATION  

Boston University, College of Engineering, Boston, MA Bachelor of Science in Biomedical Engineering May 2013 Relevant   Coursework:   Product Design and Development, Device Diagnostics, Biotransport, Thermodynamics, Molecular Biology, Neuro-Engineering, Business of Technology Innovation, Organizational Design and Development, Signals and Systems, Electric Energy Systems

SKILLS  AND  QUALIFICATIONS  

Computer: MATLAB, AutoCAD, SolidWorks, COMSOL, PTC MathCAD, SigmaPlot, ImageJ, LabVIEW, LabScribe, Applescript, MS Office Suite Other Skillsets: keen business acumen, good communicational skills, FDA knowledge

PROJECTS  

BME Senior Design Project (September 2012- May 2013)

• Designing and fabricating a microfluidic device for ultrasound manipulated filtering of circulating tumor cells from a micro-fabricated flow channel. In charge of testing acoustic properties of materials, identified a microfluidic pump for the design. Medical Product FDA Design Project (September 2012- December 2012)

• Given a PTCA Dilatation catheter, Implemented QSR specifications from 21 CFR Part 820 GMP, formed FMEA table, researched about ISO standards- 13485, made design verifications and validations, and made end presentation with re-design ideas. Design and FEA Testing (May 2012- July 2012)

• Created 3D design of John Deere tractor light frame using SolidWorks and analyzed light frame structural design to force of branches with Finite Element Analysis (FEA), and created a parts list, Bill of Materials, and assembly drawings. Business and Marketing Presentation (September 2011- December 2011)

• As a structured business team, I was given the role of Chief Marketing Officer and implemented effective strategies that will help get our newly designed product into a particular niche market. This involved advertising, CAD modeling, and team skills

EXPERIENCE   LAB ASSISTANT, WONG RESEARCH LAB, BU Boston, MA(June 2012- October 2012) • Analyzed and tracked marked cells through MATLAB® Image Processing Toolbox and studied fluorescence of cancer

proliferation patterns. • Performed Cell cultures, used Coulter Z2 Particle Counters, made PDMS microfluidic chips and made Engineered

Metastasis Platforms (EMP). TECH SALES ASSOCIATE, STAPLES INC Boston,MA (June 2010- September 2010) • Performed returns, warranties, rebates, and sales of printers, computers and other office supplies for customers. CLINICAL RESEARCHER, BOSTON MEDICAL CENTER Boston, MA (Sept 2010- January 2011) • Conducted phone interviews and brought patient samples to main hospital pavilion for testing as part of the clinical

testing process for Testosterone based drugs. ACTIVITIES  

Biomedical Engineering Society (BMES) BU member since 2011 BU Synapse Undergraduate Science Magazine Marketing Officer Spring 2010 National Honor Society Member with over 70 hours of service

Trong-Huy Vo (617) 435-1371 11 Howes St. #2 tronghuyvo@gmail.com, huy@bu.edu Boston, MA 02125

EDUCATION EXPERIENCE (Lab) EXPERIENCE (Technical) SKILLS ACTIVITIES

Boston University – Boston, MA Class of 2013 Bachelor of Science in Biomedical Engineering, Concentration in Nanotechnology Relevant courses: MATLAB, Systems Physiology, Signals & Systems, Control Systems, Thermodynamics, Solid Biomechanics, CAD & Machining, Nanomaterial & Technology, Molecular Cellular Biology, Medical Imaging Tel-Aviv University Overseas Program – Tel-Aviv, Israel Jan 2011-Jun 2011 Semester abroad, studies in engineering, Dean’s List Boston University Zhang Lab – Boston, MA Jun 2012-May 2013 Senior Project: Laboratory for Microsystems Technology, directed by Dr. Xin Zhang

Synthesized size and shape specific nanoparticles for in vitro and in vivo testing Improved a novel nanomanufacturing platform used to fabricate nanoparticles Performed procedures including: electron beam physical vapor deposition (EBPVD), scanning

electron microscopy (SEM), anodization, and chemical etching of metals Boston University CAD Lab – Boston, MA Aug 2012-Dec 2012 Design Project: Gearbox

Designed/dimensioned a gearbox with specific deliverables: torque support, load support, life, speed, and gear ratio

Modeled/analyzed gearbox in SolidWorks to meet specifications Presented gearbox to group of peers and professors

Boston University Telefund – Boston, MA Jun 2010-Dec 2010 Telefund Agent

Communicated with Boston University alumni, parents of current students, and parents of graduated students to inform about current events and fund-raising opportunities

State Street Bank – Boston, MA Jul 2009-Aug 2009 Software Programmer Intern

Managed databases with sensitive information Organized and maintained surveys and employee information

Boston Financial Data Services – North Quincy, MA Jul 2008-Aug 2008 Software Programmer Intern

Independently self-taught Powerscript and SQL Created/updated software and GUIs created by Control MIS Team in Powerscript Created/updated views and database using the SQL language and Monarch program

Computer: SolidWorks CAD, MATLAB, JAVA (class, self-taught), Powerscript (internship), Microsoft Office Suite Laboratory: Oscilloscope, Function Generator, EKG, EOG, EMG, Microscopy, Spectroscopy, Dissection (frog), Stethoscopes, Sphygmomanometers Language: English, Vietnamese (intermediate), Mandarin (basic), Hebrew (basic), Latin (basic) ● BU College of Engineering Government Class Vice-President (2012-2013) ● BU Biomedical Engineering Society (2011-2013) ● BU Asian Students Union (2009-2012) ● BLS Business Society (2006-2009) ● BLS Asian Students in Action (2005-2009) Webmaster (2008-2009) ● BLS Wolfpack Volunteer Club (2005-2009) ● BLS Red Cross Club (2005-2009) ● BLS Outdoor Track & Field (2007) ● BLS Ballroom Dancing Club (2006)

DOUGLAS TODD WEBSTER

83 Rockaway Ave. Marblehead, MA 01945 • dougwebster@comcast.net • 781-576-9717 OBJECTIVE

To obtain a business or engineering internship position for the summer prior to my enrollment in the Master of Engineering graduate program at University of California, Berkeley.

EDUCATION GPA: 3.75/4.00

Boston University College of Engineering, Boston, MA Bachelor of Science in Biomedical Engineering (May 2013) Minor in Materials Science and Engineering Technische Universität Dresden, Dresden, Germany Semester-long Study Abroad Program, Spring 2011

Relevant Coursework

Controls Systems Materials Science Molecular Cell Biology Practical Optical Microscopy Thermodynamics Transport Phenomena Signals and Systems Solid Biomechanics Systems Physiology PROJECTS

Cell Phone Based Phase Contrast Imaging Senior Project (Fall 2012 - Present) – Prototyping and miniaturizing an optical system that attaches to a cell phone camera and produces phase contrast images to resolve malarial protozoa on blood smear slides. Stent Reverse Engineering Project (Fall 2012) – Retraced the design and approval process of a peripheral artery stent including patent procedures, FDA approval, and failure mode analysis. Electronic Stethoscope Project (Fall 2011) – Designed and built an electronic phonocardiogram out of circuit elements, and wrote a MATLAB script that displayed the pulse waveform, Mayer waveform, and the average heart rate from the data. Auditory Directionality Project (Fall 2011) – Used MATLAB to convolve various sound signals with directional impulse responses in order to produce, save, and play the sounds one would hear in each ear given a certain direction of sound.

WORK EXPERIENCE

Harvard-MIT Health Sciences and Technology Biomedical Optics Summer Program (Summer 2012) Worked on a project testing the effectiveness of polarization sensitive optical frequency domain imaging using imaging processing and histology, and presented a related research poster.

Laboratory of Molecular Neurotherapeutics (Summer 2010) Worked as an assistant technician, contacting vendors and ordering hundreds of items.

SKILLS

MATLAB, Labview, Excel, Word, Adobe Photoshop, Adobe Illustrator, ImageJ, Final Cut Pro, Powerpoint, Autodesk Maya, Real-Time PCR, Beginner German and Spanish

HONORS

Recipient of the Half-Tuition Engineering Scholar’s Award Treasurer of the Tau Beta Pi Engineering Honor Society at BU Member of the Alpha Eta Mu Beta Biomedical Engineering Honor Society Member of the National Society of Collegiate Scholars Dean’s List (all semesters)

MICHAEL  T.  WEXLER  

mtwexler@bu.edu    |    (203)  561-­‐7620  28  Holbrook  Drive,  Stamford,  CT  06906  

EDUCATION    Boston  University,  Boston,  MA                                          May  2013  

College  of  Engineering  -­‐  Bachelor  of  Science,  Biomedical  Engineering     GPA:  3.68  /  4.00              Dean’s  List  (All  semesters)     Technische  Universität  Dresden,  Dresden  Germany.  Study  Abroad                                                  Spring  2011    

Relevant  Coursework:  Product  Design  and  Innovation,  Business  of  Technology  Innovation,  BioTransport,  Medical  Imaging,  Solid  Biomechanics,  Signals  and  Systems,  Control  Systems,  Thermodynamics,  Systems  Physiology,  Engineering  Mechanics  

 

EXPERIENCE      Beth-­‐Israel  Deaconess  Medical  Center,  Center  for  Advanced  Orthopedic  Study                                        05/12-­‐Present  Student  Researcher                          Boston,  MA                • Studied  effectiveness  of  biceps  tenodesis  and  meniscus  repair  techniques  using  servohydraulic-­‐testing  apparatus.    

Presented  findings  at  BMES  Conference  in  Atlanta  in  October  2012.    

DocBox,  Inc.                                                        05/12-­‐04/13  Biomedical  Engineer  Intern                                              Waltham,  MA  • Analyzed  and  compared  components  of  common  electronic  medical  record  formats  used  by  hospitals,  through  Partners  Healthcare.  • Assist  software  development  team  to  define  clinical  requirements  of  conscious  sedation  for  GE  procedure  and  for  telehealth  

devices  in  hospital  and  EMS  settings.  Utilized  Enterprise  Architect’s  workflow  analysis  tool  to  model  various  procedures.      

Boston  University  Neuromuscular  Research  Center                                    05/10-­‐05/12  Laboratory  Assistant        Boston,  MA                                                  • Recorded,  rated,  and  analyzed  movement  disorders  for  Parkinson  Disease  study  to  develop  a  wearable  sensor  that  analyzes  and  

monitors  movements  associated  with  the  disease.  Assisted  with  sensor  attachment  and  data  recording  during  human  experiments.  • Performed  EMG  signal  decomposition  and  analysis  to  study  the  effects  of  aging  and  varying  activity  levels  on  motor  unit  control.    

PROJECTS        The  Effect  of  Humeral  Positioning  on  Glenohumeral  and  Subacromial  Forces  in  a  Cadaveric  Model  of  Simulated  Pitching  05/12-­‐05/13  • Implement  TekScan  films  to  measure  glenohumeral  joint  and  subacromial  space  contact  pressures  of  an  intact  shoulder  capsule.  • Enhance  a  robotic  apparatus  that  simulates  pitching  motions  in  cadaveric  torsos  to  study  joint  kinematics  and  forces.    

Synchronized  Hand-­‐Sanitation  System                2011-­‐2012  • Designed  a  synchronized  hand-­‐sanitation  system  to  improve  hand  washing,  by  ensuring  that  users  dedicate  sufficient  time.  • Identified  need  to  improve  hygiene,  researched  patents,  products,  and  market  and  contacted  industry  professionals.  • Initiated  team  collaboration  to  move  concept  to  a  functional  prototype.  

 

ACTIVITIES      Biomedical  Engineering  Society,  BU  Chapter.  Executive  Board  member.                Alpha  Eta  Mu  Beta,  BU  Chapter  -­‐  National  BME  Honor  Society.  Executive  Board  member.      EMT  Volunteer  -­‐  Provide  life-­‐support  services  as  part  of  Advanced  Life  Support  crew.  Work  at  Stamford  EMS  and  B.U.        04/09–Present  EMS  Instructor  -­‐  EMS  lecturer  &  instructor  for  practical  skills  laboratory  course  component.                          2010-­‐Present  Stamford  Hospital  Surgical  Externship  -­‐  Observed  patient  rounds,  multiple  surgeries  of  various  specialties,  and  attended  lectures  and  trainings  in  an  intensive  two-­‐week  observation  program  offered  by  Surgical  Department  to  two  individuals.                                                                              01/11  Global  Medical  Brigades  -­‐  Volunteered  in  Honduras  to  provide  medical  and  dental  care  in  impoverished  villages.                                                            05/10    

SKILLS    Technical:     MATLAB,  EMGworks,  LabView,  SolidWorks,  ImageJ,  SigmaPlot,  PCR,  ECG,  Clinical  Devices,  Signal  Processing,  Instron  Language:     English  (fluent),  Hebrew  (conversational),  German  (elementary)  Business:     Enterprise  Architect,  Data  Analysis,  Written  Communication,  Project  Management    Certifications:     Emergency  Medical  Technician  B,  FEMA  ICS,  Pre-­‐Hospital  Trauma  Life  Support,  HazMat  Awareness,  Lifeguard,  

Water  Safety  Instructor,  and  CPR,  AED  &  First  Aid  Instructor      

PUBLICATIONS    Published  “CPR,  AED,  &  Choking”  in  The  Rehabilitation  Specialist’s  Handbook,  4th  ed.  

MICHELLE D. WONG 100 Washington St. Apt. 7 Brighton, MA 02135

857-207-7507 mwong518@gmail.com

OBJECTIVE

An entry-level position in Biomedical Engineering, preferably focused on medical research or prosthesis

development.

EDUCATION

Boston University College of Engineering, Boston, MA

Bachelor of Science in Biomedical Engineering May 2013

Related Coursework: Fundamentals of Biomaterials, Systems Physiology, Muscle Biology,

Thermodynamics, Control Systems, Mechanics of Material, Product Design and Innovation, General

Chemistry, Principles of Molecular Cell Biology

PROJECTS

Senior Project: Design and Characterization of Integrated Microfluidic System for Sample

Concentration and Extraction

Optimized a device to purify and concentrate a viral sample for point-of-care diagnostics

Designed the circuitry of a battery operated stir plate used for dialysis purification

Built the battery operated stir plate using a computer fan, a switch, a potentiometer, and a 9V battery

Built a portable vacuum source for concentration of the viral sample via evaporation.

Eye Communication via EOG Data September 2011-December 2011

Analyzed the electrooculogram system in order to understand vertical and horizontal eye movement.

Designed two separate systems based on human eye movements to control an LED circuit and move

a computer cursor simultaneously through MATLAB in real time.

EXPERIENCE

Lab Assistant January 2012 - Present

Klapperich Lab for Diagnostics and Global Healthcare Technologies, BU Boston, MA

Extracted viral RNA from a sample

Performed qRT-PCR to analyze presence of HIV1

Determined protein concentrations of various samples to compare efficiency of sample purification

Fabricated microfluidic chips used for purification and concentration of viral sample for point-of-

care diagnostics

Lab Assistant May 2011 - December 2011

Xue Han Lab, BU Boston, MA

Designed and constructed electric circuit used in mice training box

Trained laboratory mice to do various tasks

Analyzed data with MATLAB for weekly reports of mice training

Stripped fiber optics and assisted with tetrode assembly

Recorded weekly inventory of mice

Developed new organized filing system for packaging slips and receipts

SKILLS

Laboratory: qRT-PCR, Bicinchoninic acid (BCA) Assay, RNA extraction.

Computer: Microsoft Word, MATLAB, SolidWorks, Adobe Illustrator

PUBLICATIONS

Ho, N., Fan, A., LaCroix, R.M., Wong, M.D., Klapperich, C.M., Cabodi, M., “Sample concentration and

purification for point-of-care diagnostics”, Analytical Chemistry (in preparation).

10 Buick Street #8516. Boston, MA 02215 allenyen@bu.edu – 626.354.8717 http://www.linkedin.com/pub/allen-yen/20/941/184 EDUCATION Boston University College of Engineering Boston, MA Bachelor of Science in Biomedical Engineering, Concentration in Nanotechnology May 2013

EXPERIENCE Boston University School of Medicine September 2011 – Present Undergraduate Researcher Boston, MA

Spearheading a study of the mechanism of PLA2g6 involvement in the store-operated calcium entry pathway in the SH-SY5Y dopaminergic cell model

Cedars-Sinai Maxine-Dunitz Neurosurgical Institute Summers 2011, 2012 Research Assistant Los Angeles, CA

Performed tail vein injections, in-vivo imaging, harvesting of organs, and mouse biomethodology techniques

Developed and tested nanomolecules for the delivery of therapeutic agents in mice models of glioblastoma (GBM) USC Norris Comprehensive Cancer Center May 2010 – August 2010 Research Assistant Los Angeles, CA

Executed experiments to study the effects of protein DNA interaction on methylation patterns in human cells Stemcyte Inc. May 2009 – August 2009 Intern Covina, CA

Carried out HLA-typing experiments to match cord blood donors with potential recipients

PROJECTS Development of Nanomanufacturing Platform for Hydrogel Nanoparticles September 2012 – May 2013

Developed an anodized aluminum oxide template and quartz molds to fabricate hydrogel nanorods for the delivery of TaOx nanoparticle CT contrast agents

Medtronic Hancock II T505 Cinch Heart Valve Product Development September 2012 – December 2012

Applied best practices for bioengineering device development including product development via design and process control, intellectual property and innovation, and clinical regulations and clinical trial design

Directional Hearing Aid Display September 2011 – December 2011

Designed and built a hearing aid display that could determine the direction of sound and translate the information into lighting up a corresponding LED

PUBLICATIONS & PRESENTATIONS Lee BS, Amano T, Wang HQ, Pantoja JL, Yoon CW, Hanson CJ, Amatya R, Yen A, Black KL, Yu JS: Reactive Oxygen Species Responsive Nanoprodrug to Treat Intracranial Glioblastoma. ACS Nano. doi: 10.1021/nn400347j2013. April 4, 2013. Zhou Q, Rymarzyk G, Schäfer C, Yen A, Kirber MT, Aziz N, Asai H, Wolozin BL, Ikezu T, Bolotina VM: Genetic Truncation of PARK14 Unmasks Causal Relationship Between Store-Operated Ca2+ Entry and Parkinson’s Disease-like Phenotype in a Novel Mouse Model. (submitted, pending review) Chodakiewitz Y, Yen A, Subhash Amith, Lee BS, Black KL, Yu JS: Nanoprodrug of Paclitaxel for Glioblastoma Treatment. Invited poster at 10th Annual World Congress of Society of Brain Mapping & Therapeutics, Baltimore, MD. May 12, 2013. SKILLS mouse biomethodology, calcium imaging, histology, immunohistochemistry, HPLC, DLS, rotavapor distillation, qPCR, Southern/Western blot, confocal microscopy, MATLAB, MathCAD, ImageJ, Solidworks, Photoshop, Indesign, Illustrator

AWARDS & ASSOCIATIONS Undergraduate Research Opportunities Program (UROP) Funding Recipient, Fall 2012, Spring 2013 American Physiological Society, member since 2013 Biomedical Engineering Society, member since 2011 Boy Scouts of America (BSA) Eagle Scout, 2009

Alexander Y. Yoon 833 Beacon St. APT 502, Boston, MA 02215 | 914-413-1364 | ayoon@bu.edu

Education

BACHELORS OF SCIENCE | MAY 2013 | BOSTON UNIVERSITY COLLEGE OF ENGINEERING

· Major: Biomedical Engineering

· Related coursework: General Chemistry, General Physics, Cellular & Molecular Biology and Biotechnology, Systems Physiology, Biomedical Measurements, Introductory Calculus, Multivariable Calculus, Differential Equations, Probability and Statistics, Signals and Systems, Control Systems Engineering, Introduction to Thermodynamics, Transport Phenomena in Biological Systems, Fundamentals of Fluid Mechanics, Introduction to Neuroengineering, Biomaterials, Biological Physics, and Nanomedicine: Principles and Applications.

Skills & Abilities

MANAGEMENT

· The coursework throughout my undergraduate training allowed exposure to various group projects. The types of projects ranged from short term engineering design-based projects to semester-long projects that focused on particular industries which focused on industry analysis (Business Course).

COMPUTATIONAL SKILLS

· Utilized software, such as Excel and MATLAB, for data analysis for large sets of data.

· Generate functions using Java to increase rate of work flow.

COMMUNICATION

· When working on the various group projects, utilizing various modes of communication was integral in the efficiency in workflow. Online tools, such as google docs and dropbox, became a necessary part of the collaborative environment, along with the existing qualities members should exhibit (punctuality, tolerance, etc).

· Along with small group communication, presentation of ideas to larger groups was practiced. Much of the projects required a presentation of ideas in structured format.

Experience

RESEARCH ASSISTANT | NEUROENGINEERNING LAB (HAN LAB) | AUGUST 2011 TO PRESENT

· My role in the lab started off from genotyping transgenic mice to performing histology on brain sections to characterize neuronal systems. My role then evolved to investigating in vivo delivery of genes through synthetic methods (liposomes).

RESEARCH VOLUNTEER | TUFTS MEDICAL CENTER | MAY 2011 TO AUGUST 2011

· I had the opportunity shadow Dr. Mark Link in a clinical setting. I was also involved in research regarding commotio cordis, performing data analysis and management (of ECGs).

Luai Zakarialzaka@bu.edu(502) 541-7203

EDUCATION BOSTON UNIVERSITY College of Engineering Expected Graduation: May 2013Bachelor of Science, Biomedical Engineering Boston, MAGPA: 3.35/4.0, Cum Laude

SKILLS Prototyping and Machining (SolidWorks), Computer Programming (MATLAB, C++, Java),Electrical and Mechanical Testing (LabVIEW, Instron), Analyze Imaging Resource: ImageProcessing and Analysis, Filemaker Pro, OnBase Database

PROJECTS Senior Capstone Project Fall 2012-PresentLab for Engineering Education and Development Boston, MABoston University College of Engineering● Research Goal: Designing and developing a novel continuous positive airway pressure

(CPAP) medical device for treating neonatal pneumonia in developing countries.● Lab Responsibilities: Designing a prototype device (SolidWorks), machining parts, testing

mechanical and electrical components of the device, and identifying necessary productfunctional and performance specifications for the client in Lusaka, Zambia.

RELEVANT Research Assistant Summer 2011-PresentEXPERIENCE Beth Israel Deaconess Medical Center Boston, MA

Harvard Medical School/Boston University Research Goal: Investigating the effect of cationic Computed Tomography (CT) contrast

agent in orthopaedic imaging to enhance modern imaging techniques for the early detectionof osteoarthritis.

Lab Responsibilities: Designing imaging fixtures using SolidWorks, scanning samples withmicro CT scanner, post image processing using Analyze Imaging Resource, runningbiochemical assays, writing MATLAB programs to analyze biomechanical data.

PUBLICATIONS & Abstract & Poster: Orthopaedic Research Society 2013PRESENTATIONS "Synthetic Biolubricant Reduces Cartilage Coefficient of Friction and Wear during Long-

Duration Torsional Testing"Benjamin Lakin, Luai Zakaria, Daniel Grasso, Michel Wathier, Brian Snyder, Mark Grinstaff

Poster: ASME Nanoengineering for Medicine and Biology 2013"Contrast-Enhanced CT Imaging using a Novel Cationic Contrast Agent Can DetermineMechanical Properties of Articular Cartilage"Benjamin Lakin, Daniel Grasso, Luai Zakaria, Prashant Bansal, Mark Grinstaff, Brian Snyder

Abstract & Poster: Boston University Undergraduate Research Symposium 2012"Cationic Contrast Enhanced Computed Tomography for Predicting GlycosaminoglycanContent in Bovine Anterior Cruciate Ligament (ACL)"Luai Zakaria, Benjamin Lakin, Martin Wiewiorski, Brian Snyder, Mark Grinstaff

ADDITIONAL Resident Assistant Fall 2011-PresentEXPERIENCE Boston University Residence Life Boston, MA

Developing a healthy community for a group of forty students, predominantly freshmen,providing control of the residence, performing administrative tasks, implementing crisismanagement strategies in high tension conflict scenarios

Local Address700 Commonwealth Ave.Boston, MA 02215 Box 2110

Permanent Address12514 Bridgetown PlaceLouisville, KY 40245

MICHAEL ZHANG9 Grizzly Bear Circle, Westford, MA 02134 mhzhang@bu.edu 617-416-0570

EDUCATIONBoston University College of Engineering Boston, MABachelor of Science in Biomedical Engineering May 2013

Relevant Coursework:Applications of Tissue Engineering, Biomaterials, Structures and Functions of the Extracellular Matrix, Systems Physiology, Solid Continuum Mechanics, Fluid Continuum Mechanics, Thermodynamics, Cell Biology, Biomedical Instrumentation, Biological Measurements, Product Design and FDA Regulations, Control Systems, Microelectronics and Circuit Design, Logic Design, Signals and Systems, Speech Processing

SENIOR PROJECTScaffold Design in Vascular Tissue Engineering September 2012-presentSchepens Eye Research Institute Boston, MA

• Developing a porous PCL film as scaffold design for a vascular graft• Culturing endothelial cells and performing transmigration assay with H&E stain• Observing cell proteins using immunohistochemistry• Designing scaffold photomask on Layout Editor • Using microfabrication techniques to design scaffold mold with silicon wafers• Peeling PCL film off silicon mold

WORK EXPERIENCEIntern May 2012-October 2012HealthMob Inc. Cambridge, MA

• Developed Android mobile application in Java with Eclipse and IntelliJ• Paired latest developed app with a heart rate sensor hardware to verify performance• Collected mass composition data using weight scales and bio-impedance meter• Soldered USB wires to optimal length for scale testing

Research Assistant March 2011-January 2012Molecular Biotechnology Research Laboratory, Boston University Boston, MA

• Researched relationship between cell metabolite levels and schizophrenia• Cultured B-lymphocyte cell lines • Analyzed cell population to know optimal cell passaging times• Obtained retention data of cell extracts using HPLC

Research Assistant February 2011-March 2012Solid State Physics Laboratory, Boston University Boston, MA

• Researched superconductor resistance at low temperatures• Collected voltage data across superconductors at low temperatures with LabVIEW • Soldered wires to build specified circuits

COMPUTER SKILLSMicrosoft Office, Matlab, Java, LabVIEW, Eclipse, IntelliJ, Layout Editor

YUJIE ZHOU

gordonzh@bu.edu 6178990818 1156 Commonwealth Avenue, Allston, MA 02134

OBJECTIVE

An entry level biomedical engineer with strong basis in math and engineering skills,

thorough practice in lab experiments and projects, and great enthusiasm in furthering

various engineering experience and work ethics.

EDUCATION

BOSTON UNIVERSITY, Boston, MA May 2013

B.S in Biomedical Engineering

Dean’s List (2 Semesters)

Related Coursework

Computational Modeling of Extracellular Matrix

Biomaterials, Bio-transport, Optical Microcopy

Control Systems in Biomedical Engineering

Thermodynamics, Product Design, Physiology

Molecular and Cellular Biology, Circuit Theory

Projects

Linear Stretch Bioreactor Khademhosseini Lab, Harvard-MIT HST, Cambridge, MA Fall 2012

• Developing gripping method of hydrogel scaffold in stretch bioreactor for

cardiac tissue engineering

Electronics Control through Saccadic Eye Movement BU, Boston, MA Fall 2011

• Achieved switch control and light intensity control over multiple LEDs by eye

movement detection.

Virtual Acoustic Sound Analysis BU, Boston, MA Fall 2011

• Achieved sound location identification by correlating hearing transfer

functions of ears and original sound function.

Truss Design and Analysis BU, Boston, MA Fall 2010

• Designed and constructed truss bridge model with prospective load and

resistance.

WORK EXPERIENCE

BRIGHAM AND WOMEN’S HOSPITAL, Boston, MA – Research Trainee Spring 2013

INSTITUTE OF BIOMEDICAL ENGINEERING CHINESE ACADEMY OF MEDICAL

SCIENCES, Tianjin, China – Research Assistant Summer 2012

KWONG KOW SCHOOL, Boston, MA – Teaching Assistant Spring 2010

LAB SKILLS

Confocal Imaging, TIRF Imaging, Fluorescence Microscopy, Phase Contrast Imaging

Molecular cloning, Restriction Enzyme Digestion, Agarose gel electrophoresis

Ligation and transformation of DNA, PCR, DNA fluorescence identification

ACTIVITIES

Boston University Composers and Musician