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Chapter 1: Intro to Biochemistry C483 Spring 2013

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Questions 1.T/F The Golgi apparatus consists of flattened, fluid-filled, membranous sacs and is responsible for chemical modification and sorting of some biomolecules. 2.T/F The endoplasmic reticulum is the major site of RNA synthesis and the site of assembly of ribosomes. 3. Which functional group is shown? A) Primary amine. B) Acyl. C) Amide. D) Anhydride. E) Nitrile.

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4. Which is NOT a proper way to form a hydrogen bond? (The symbol "R" represents a general organic group. The hydrogen bonding is represented by dashed lines.) 5. The aggregation of nonpolar molecules or groups in water is thermodynamically due to the A) increased entropy of the nonpolar molecules when they associate. B) decreased enthalpy of the system. C) increased entropy of the water molecules. D) very strong van der Waals forces among the nonpolar molecules or groups. 6. Cells keep the osmotic pressure from being too great by A) existing in hypertonic solutions. B) making macromolecules from smaller molecules. C) existing in a hypotonic solution. D) existing in an isotonic solution. E) Both B and D.

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Biological Chemistry Cartoon picture of a virus Nucleic acid wrapped in protein shell Structural biology Biochemistry Chemical biology We will study a coronavirus in discussion section

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On the atomic level

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Major Topics

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Organic Chemistry Review: Section 1.2

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Biology Review: Sections 1.8-1.9 Know functions of organellesBe able to describe cytosol

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Chapter 2: WATER Properties of water based on H-bonding Density Specific heat Heat of vaporization

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Water Solubility Solvation of particles based on intermolecular interactions Polar molecules Ionic substances

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Solution Chemistry Diffusion Osmotic Pressure How does formation of glycogen affect osmotic pressure?

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Water and Nonpolar Compounds Nonpolar compounds do not dissolve in waterthey aggregate to minimize surface area Hydrophobic effect Driven by minimization of ordering of water (increases the entropy of solution)

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In Discussion Section Section 2.5 Electrostatic interactions Charge-charge Hydrogen bonding Van der Waals Section 1.4, 2.6 Energetics of reactions of water Condensation vs. hydrolysis Thermodynamic stability Kinetci stability

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Answers to Questions 1.T 2.F 3.C 4.II 5.C 6.E