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    Biophysics Exam

    Chapter 2 Biothermodynamics

    What is Biothermodynamics?

    The studying of:

    1. The states of equilibrium of material systems

    2. The processes by which these equilibrium states are reached

    3. The energetic aspects of physical and chemical processes in material systems

    4. Direction and limits of developing spontaneous processes.

    When thermodynamics deals with biological systems it is called Biothermodynamics.

    The statement of the first law of Thermodynamics

    U = Q+L

    U: Internal energy

    Q: Heat

    L: Labour

    A change in the internal energy of a closed thermodynamic system is equal to the difference

    between the heat supplied to the system and the amount ofwork done by the system on its

    surroundings.

    What is a chemodynamic system?

    In chemodynamic systems a part of the chemical energy is transformed to heat and another

    part of it to mechanical work. The living organism is a chemodynamic system.

    What are the types of isothermal coefficients?

    Physical isothermal coefficients: which is the quantity of energy released by one gram of food

    fully oxidized in oxygen atmosphere and where the end results are water and carbon dioxide.

    Physiological isothermal coefficients: are expressing the quantity of energy released in

    organism during the oxidation reaction of one gram food.

    Practical isothermal coefficients: are also physiological coefficients but they take to account

    the digestibility/absorption degree of food.

    What is metabolic rate and basal metabolism?

    Basal Metabolic Rate (BMR), and the closely related resting metabolic rate (RMR), is the

    amount of daily energy expended by humans and animals at rest. Rest is defined as existing in

    a neutrally temperate environment while in the post-absorptive state. In plants, different

    considerations apply.

    The release of energy in this state is sufficient only for the functioning of the vital organs,

    the heart, lungs, nervous system, kidneys, liver, intestine, sex organs, muscles, and skin.

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    Relation between thermodynamic probability and entropy

    The thermodynamic probability of a state is defined as the number of micro states of the

    system that corresponding to the given macro state.

    The thermodynamic probability and entropy will increase if the organizing degree of

    molecules is decreasing. ( S= entropy, = thermodynamic probability and they are related to

    the entropy Sby S= kln , where kis Boltzmann's constant.

    What is negative entropy?

    Thermodynamic entropy is a measure of how organized or disorganized energy is present in a

    system of atoms or molecules. An ordered system has less entropy than an disordered one.

    The negentropy, also negative entropy or syntropy, of a living system is the entropy that itexports to keep its own entropy low; it lies at the intersection ofentropy and life.

    How the second law of thermodynamics is applied to living organisms?

    Trying to apply the second principle of thermodynamics at living organism, was found that

    the validity is questioned, as they evolve to increase structural complexity and diversification

    of structures, in which case the entropy will decrease.

    Chapter 3 Water

    Water in living organisms, distribution, roles and forms?

    Water is the medium where multiple hydrolysis and enzymatic reactions take place (by

    hydrogen ions) and it results as a final product of the condensing reactions and

    biological oxidations.

    It contributes in maintaining the constant temperature of organisms (by thermal

    conductibility and vaporization heat, all very high).

    It is the universal solvent in the interstitial (versttning: 1. Relating to, occurring in,

    or affecting interstices.) and intracellular medium where it forms real or colloidal(versttning: A system in which finely divided particles, which are approximately 10

    to 10,000 angstroms in size, are dispersed within a continuous medium in a manner

    that prevents them from being filtered easily or settled rapidly.)solutions transported

    by water

    It is the transport medium between organs, using extra cellular circulating fluids

    Its the medium necessary to eliminate products of catabolism out of the organism

    (urine and transpiration) (versttning: the process of giving off or exhaling water

    vapor through the skin or mucous membranes)

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    The Nernst & Goldmans relation

    In electrochemistry, the Nernst equation is an equation that can be used (in conjunction with

    other information) to determine the equilibrium reduction potential of a half-cell in

    an electrochemical cell. It can also be used to determine the total voltage (electromotive force)

    for a full electrochemical cell. It is named after the German physical chemist who first

    formulated it, Walther Nernst.

    The GoldmanHodgkinKatz voltage equation, more commonly known as the Goldman

    equation is used in cell membrane physiology to determine the equilibrium potential across acell's membrane taking into account all of the ions that are permeate through that membrane.

    The description of the membrane through electrical equivalent circuits

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    Chapter 5 Transport through membranes

    Types of transport in cell membrane and the differences between them

    Active transport is the movement of a substance against its concentration gradient (from low

    to high concentration). In all cells, this is usually concerned with accumulating high

    concentrations of molecules that the cell needs, such as ions, glucose, and amino acids. If the

    process uses chemical energy, such as from adenosine triphosphate (ATP), it is

    termed primary active transport. Secondary active transport involves the use ofan electrochemical gradient. Active transport uses energy, unlike passive transport, which

    does not use any type of energy. Active transport is a good example of a process for which

    cells require energy. Examples of active transport include the uptake of glucose in the

    intestines in humans and the uptake of mineral ions into root hair cells of plants.

    Primary active transport, also called direct active transport, directly uses energy to transport

    molecules across a membrane.[1]

    Most of the enzymes that perform this type of active transport are transmembrane ATPases. A

    primary ATPase universal to all cellular life is the sodium-potassium pump, which helps to

    maintain the cell potential. Other sources of energy for Primary active transport

    areredox energy andphotonenergy (light). An example of primary active transport using

    Redox energy is the mitochondrial electron transport chain that uses the reduction energy

    http://en.wikipedia.org/wiki/Primary_active_transport#cite_note-0http://en.wikipedia.org/wiki/Redoxhttp://en.wikipedia.org/wiki/Redoxhttp://en.wikipedia.org/wiki/Photonhttp://en.wikipedia.org/wiki/Photonhttp://en.wikipedia.org/wiki/Lighthttp://en.wikipedia.org/wiki/Electron_transport_chainhttp://en.wikipedia.org/wiki/Redoxhttp://en.wikipedia.org/wiki/Photonhttp://en.wikipedia.org/wiki/Lighthttp://en.wikipedia.org/wiki/Electron_transport_chainhttp://en.wikipedia.org/wiki/Primary_active_transport#cite_note-0
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    ofNADH to move protons across the inner mitochondrial membrane against their

    concentration gradient. An example of primary active transport using light energy are the

    proteins involved inphotosynthesisthat use the energy of photons to create a proton gradient

    across thethylakoid membrane and also to create reduction power in the form ofNADPH.

    In secondary active transport orco-transport, uses energy to transport molecules across a

    membrane; however, in contrast toprimary active transport, there is no direct coupling

    ofATP; instead, theelectrochemical potential difference created by pumping ions out of the

    cell is used. [1]

    The two main forms of this areantiport and symport.

    Passive transport means moving biochemical and other atomic or molecular substances

    across membranes. Unlike active transport, this process does not involve chemical energy,

    because, unlike in an active transport, the transport across membrane is always coupled with

    the growth ofentropy of the system. So passive transport is dependent on the permeability of

    the cell membrane, which, in turn, is dependent on the organization and characteristics of themembrane lipids and proteins. The four main kinds of passive transport

    are diffusion, facilitated diffusion, filtration and osmosis.

    Diffusion describes the spread ofparticles through random motion from regions of

    higherconcentration to regions of lower concentration. The time dependence of the statistical

    distribution in space is given by thediffusion equation. The concept of diffusion is tied to that

    ofmass transferdriven by a concentration gradient. Diffusion is invoked in the social sciences

    to describe the spread of ideas.

    Facilitated diffusion (also known as facilitated transport orpassive-mediated transport)

    is a process ofpassive transport, facilitated by integral proteins. Facilitated diffusion is thespontaneous passage of molecules or ions across a biological membrane passing through

    specific transmembrane integral proteins. The facilitated diffusion may occur either

    acrossbiological membranesor through aqueous compartments of an organism.

    Filtration is commonly the mechanical or physical operation which is used for the separation

    of solids from fluids (liquids or gases) by interposing a medium through which only the fluid

    can pass. Oversize solids in the fluid are retained, but the separation is not complete; solids

    will be contaminated with some fluid and filtrate will contain fine particles (depending on the

    pore size and filter thickness). Filtration is also used to describe somebiological processes,

    especially in water treatment andsewage treatment in which undesirable constituents are

    removed by adsorption into a biological film grown on or in the filter medium.

    Osmosis is the movement ofsolvent molecules through a selectivelypermeable membrane

    into a region of highersoluteconcentration, aiming to equalize the solute concentrations on

    the two sides.[1][2][3]It may also be used to describe a physical process in which any solvent

    moves, without input of energy,[4]across a semipermeable membrane (permeable to

    thesolvent, but not the solute) separating two solutions of different concentrations.[5] Although osmosis does not require input of energy, it does use kinetic energy[6] and can be

    made to do work.[7]

    Chapter 6 Membrane potential

    The causes of the resting potential

    http://en.wikipedia.org/wiki/NADHhttp://en.wikipedia.org/wiki/Photosynthesishttp://en.wikipedia.org/wiki/Photosynthesishttp://en.wikipedia.org/wiki/Thylakoid_membranehttp://en.wikipedia.org/wiki/Thylakoid_membranehttp://en.wikipedia.org/wiki/NADPHhttp://en.wikipedia.org/wiki/Primary_active_transporthttp://en.wikipedia.org/wiki/Adenosine_triphosphatehttp://en.wikipedia.org/wiki/Electrochemical_potentialhttp://en.wikipedia.org/wiki/Electrochemical_potentialhttp://en.wikipedia.org/wiki/Secondary_active_transport#cite_note-0http://en.wikipedia.org/wiki/Antiporthttp://en.wikipedia.org/wiki/Antiporthttp://en.wikipedia.org/wiki/Symporthttp://en.wikipedia.org/wiki/Particlehttp://en.wikipedia.org/wiki/Concentrationhttp://en.wikipedia.org/wiki/Diffusion_equationhttp://en.wikipedia.org/wiki/Diffusion_equationhttp://en.wikipedia.org/wiki/Mass_transferhttp://en.wikipedia.org/wiki/Passive_transporthttp://en.wikipedia.org/wiki/Passive_transporthttp://en.wikipedia.org/wiki/Biological_membranehttp://en.wikipedia.org/wiki/Biological_membranehttp://en.wikipedia.org/wiki/Biologyhttp://en.wikipedia.org/wiki/Water_treatmenthttp://en.wikipedia.org/wiki/Sewage_treatmenthttp://en.wikipedia.org/wiki/Sewage_treatmenthttp://en.wikipedia.org/wiki/Solventhttp://en.wikipedia.org/wiki/Semipermeable_membranehttp://en.wikipedia.org/wiki/Solutehttp://en.wikipedia.org/wiki/Osmosis#cite_note-0http://en.wikipedia.org/wiki/Osmosis#cite_note-0http://en.wikipedia.org/wiki/Osmosis#cite_note-0http://en.wikipedia.org/wiki/Osmosis#cite_note-1http://en.wikipedia.org/wiki/Osmosis#cite_note-1http://en.wikipedia.org/wiki/Osmosis#cite_note-2http://en.wikipedia.org/wiki/Osmosis#cite_note-Waugh_2006-3http://en.wikipedia.org/wiki/Osmosis#cite_note-Waugh_2006-3http://en.wikipedia.org/wiki/Solventhttp://en.wikipedia.org/wiki/Solventhttp://en.wikipedia.org/wiki/Osmosis#cite_note-4http://en.wikipedia.org/wiki/Osmosis#cite_note-5http://en.wikipedia.org/wiki/Osmosis#cite_note-5http://en.wikipedia.org/wiki/Osmosis#cite_note-6http://en.wikipedia.org/wiki/NADHhttp://en.wikipedia.org/wiki/Photosynthesishttp://en.wikipedia.org/wiki/Thylakoid_membranehttp://en.wikipedia.org/wiki/NADPHhttp://en.wikipedia.org/wiki/Primary_active_transporthttp://en.wikipedia.org/wiki/Adenosine_triphosphatehttp://en.wikipedia.org/wiki/Electrochemical_potentialhttp://en.wikipedia.org/wiki/Secondary_active_transport#cite_note-0http://en.wikipedia.org/wiki/Antiporthttp://en.wikipedia.org/wiki/Symporthttp://en.wikipedia.org/wiki/Particlehttp://en.wikipedia.org/wiki/Concentrationhttp://en.wikipedia.org/wiki/Diffusion_equationhttp://en.wikipedia.org/wiki/Mass_transferhttp://en.wikipedia.org/wiki/Passive_transporthttp://en.wikipedia.org/wiki/Biological_membranehttp://en.wikipedia.org/wiki/Biologyhttp://en.wikipedia.org/wiki/Water_treatmenthttp://en.wikipedia.org/wiki/Sewage_treatmenthttp://en.wikipedia.org/wiki/Solventhttp://en.wikipedia.org/wiki/Semipermeable_membranehttp://en.wikipedia.org/wiki/Solutehttp://en.wikipedia.org/wiki/Osmosis#cite_note-0http://en.wikipedia.org/wiki/Osmosis#cite_note-1http://en.wikipedia.org/wiki/Osmosis#cite_note-2http://en.wikipedia.org/wiki/Osmosis#cite_note-Waugh_2006-3http://en.wikipedia.org/wiki/Solventhttp://en.wikipedia.org/wiki/Osmosis#cite_note-4http://en.wikipedia.org/wiki/Osmosis#cite_note-5http://en.wikipedia.org/wiki/Osmosis#cite_note-6
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    The resting potential of a cell is the membrane potential that would be maintained if there

    were no action potentials, synaptic potentials, or other active changes in the membrane

    potential. In most cells the resting potential has a negative value, which by convention means

    that there is excess negative charge inside compared to outside. The resting potential is mostly

    determined by the concentrations of the ions in the fluids on both sides of the cell

    membrane and the ion transport proteins that are in the cell membrane. How the

    concentrations of ions and the membrane transport proteins influence the value of the resting

    potential is outlined below.

    The resting potential depend on:

    The type of the cell

    Its functional status

    Composition of the extra cellular environment

    The action potential

    Inphysiology, an action potential is a short-lasting event in which the electrical membrane

    potential of a cell rapidly rises and falls, following a consistent trajectory. Action potentials

    occur in several types ofanimal cells, calledexcitable cells, which includeneurons,muscle

    cells, and endocrine cells, as well as in someplant cells .Action potentials are generated by

    special types ofvoltage-gated ion channels embedded in a cell'splasma membrane. These

    channels are shut when the membrane potential is near the resting potential of the cell, but

    they rapidly begin to open if the membrane potential increases to a precisely defined threshold

    value. When the channels open, they allow an inward flow ofsodium ions, which changes theelectrochemical gradient, which in turn produces a further rise in the membrane potential.

    This then causes more channels to open, producing a greater electric current, and so on.

    The action potential has 5 phases:

    1. The resting potential ( few potassium channels are open), ( There is no NET

    movement of K ions)

    2. Threshold (As the depolarizing stimulus appear, few Na channels are open) , (When

    Na ions enter the cell the membrane potential is less negative), ( When the threshold is

    achieved the action potential is generated)

    3. The rising phase ( the depolarization reaches the threshold potential), (additional

    voltage-gated sodium channels are open), ( a high flow of Na ions enter the cell), (the

    membrane voltage becomes positive)

    4. The falling phase ( at the peak of the action potential, two processes occur

    simultaneously ; many voltage- gated sodium channels begin to close and many more

    potassium channels open), (the positive charge leaves the cell), (the membrane

    potential begins to shift back to the resting potential), ( as the membrane potential

    approaches the resting potential all voltage-gated potassium channels are open and

    maximally activated)

    http://en.wikipedia.org/wiki/Animal_cellhttp://en.wikipedia.org/wiki/Membrane_potentialhttp://en.wikipedia.org/wiki/Membrane_potentialhttp://en.wikipedia.org/wiki/Neuronhttp://en.wikipedia.org/wiki/Neuronhttp://en.wikipedia.org/wiki/Endocrinehttp://en.wikipedia.org/wiki/Plant_cellhttp://en.wikipedia.org/wiki/Voltage-gated_ion_channelhttp://en.wikipedia.org/wiki/Voltage-gated_ion_channelhttp://en.wikipedia.org/wiki/Sodiumhttp://en.wikipedia.org/wiki/Sodiumhttp://en.wikipedia.org/wiki/Animal_cellhttp://en.wikipedia.org/wiki/Membrane_potentialhttp://en.wikipedia.org/wiki/Neuronhttp://en.wikipedia.org/wiki/Endocrinehttp://en.wikipedia.org/wiki/Plant_cellhttp://en.wikipedia.org/wiki/Voltage-gated_ion_channelhttp://en.wikipedia.org/wiki/Sodium
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    5. The recovery phase ( the membrane repolarizes below the resting potential because of

    the number of the potassium channels that are open), ( the additional potassium

    channels now close)

    Each action potential is followed by a refractory period : 1. Absolute refractory period it

    is impossible to evoke another action potential 2. Relative refractory period a stronger

    than usual stimulus is required.

    Chapter 7 Blood circulation + Chapter 8 Muscle contraction + Chapter 9 vision system

    + Chapter 10 Hearing system + Chapter 11 Respiration system

    Poiseuille-Hagen's law

    In fluid dynamics, the HagenPoiseuille equation is a physical law that gives

    the pressure drop in a fluid flowing through a long cylindrical pipe. The assumptions of the

    equation are that the flow is laminar viscous and incompressible.

    The total flow D of a cylindrical tube is given by:

    P: Pressure

    R: Radius

    L: Lenght

    If radius diminishes with only 16%, the flow will diminish

    to half of its initial value.

    If radius diminishes with 50%, flow will be 16 times

    lower.

    Bernoulli's equation

    In fluid dynamics, Bernoulli's principle states that for an inviscid flow, an increase in thespeed of the fluid occurs simultaneously with a decrease in pressure or a decrease in

    the fluid's potential energy.

    P: Pressure

    Pv: is the fluid flow speedat a point on a streamlineP: Density

    Laplace Law

    http://en.wikipedia.org/wiki/Speedhttp://en.wikipedia.org/wiki/Speedhttp://en.wikipedia.org/wiki/Speed
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    In physics, the YoungLaplace equation is a nonlinear partial differential equation thatdescribes the capillary pressure difference sustained across the interface between two static

    fluids, such as water and air, due to the phenomenon ofsurface tension or wall tension,

    although usage on the latter is only applicable if assuming that the wall is very thin.

    P: Pressure, R: Radis F: Force

    Chapter 8

    The 4 mechanisms that produce motility

    actine-myosine (interaction between these proteins producemotility - muscular contraction,

    cytoplasmic current and amiboid movements) uses ATP energy

    tubulin-dynein (flagella and cilla motion inside the eukaryotes cells, chromosomes motionduring cellular division, intra cytoplasm motions) uses ATP energy

    flagellin (a contractile protein used in bacteria's motion; a complex rotational system) uses

    ATP energy

    spasmin (produces contraction based on calcium binding,same way as in poly-electrolytic

    chain) uses ATP energy to pump calcium through active transport

    V. Hill's law

    F = loading force

    v = shortening velocity

    F0 = loading force in isometric contraction

    a is a constant having approximately the same values for all types of muscles

    (meaning that chemo-mechanical efficiency is similar for all types of muscles)

    b is a constant that has a specific value for each type of muscle

    Muscle Shortening Mechanism

    In the absence of calcium ions, tropomyosin blocks access to the mysosin binding site

    of actin

    When calcium binds to troponin, the myosin has access to binding site on actin

    Myosin hydolyzes ATP and undergoes a conformational change into a high-energy state.

    The head group of myosin binds to actin forming a crossbridge between the thick and

    thin filaments

    The energy stored by myosin is released => ADP and inorganic phosphate dissociate frommyosin. The resulting relaxation of the myosin molecule entails rotation of the

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    globular head (=> longitudinal sliding of the filaments)

    it's like a rowboat movement

    The Purkinje effect

    is the tendency for the peak luminance sensitivity of the human eye to shift toward the blue

    end of the color spectrum at low illumination levels. This effect introduces a difference in

    color contrast under different levels of illumination. For instance, in

    bright sunlight, geranium flowers appear bright red against the dull green of their leaves, or

    adjacent blue flowers, but in the same scene viewed at dusk, the contrast is reversed, with the

    red petals appearing a dark red or black, and the leaves and blue petals appearing relatively

    bright.

    Defects of eyes

    Presbyopia the ability to accommodate is reduced (due to the loss of elasticity of the

    crystalline lens)

    Astigmatism due to defects of sphericity of the transparent Cornea

    Myopia near-sightedness. F is in front of retina because eye is too long or power is too

    high

    Hyperopia far-sightedness. F is behind retina because eye is too short or power is too low

    Fick's law applied to gases

    Fick's laws of diffusion describe diffusion and can be used to solve for the diffusion

    coefficient,D.

    s represents the solubility coefficient of gases in liquid

    Dalton's law of partial pressures

    In chemistry and physics, Dalton's law (also called Dalton's law of partial pressures) states

    that the total pressure exerted by a gaseous mixture is equal to the sum of the partial

    pressures of each individual component in a gas mixture.

    the barometric (atmospheric) pressurepB is

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    Structure of the eye

    The three optic mediums of the eye are:

    1. the aqueous humour (n=1.336) fills the anterior compartment of the eye which is limited

    towards the air by transparent cornea and towards the eye by iris

    2. the crystalline (nav=1.406) is a biconvex, asymmetric lens. It is an elastic tissue composed

    of thin lens. The shape of the crystalline may vary due to ciliary muscles that surround it.

    3. the vitreous humour (n=1.336) is limited in the posterior part by the retina (which contains

    the photosensitive cells).

    OBS: The chemical composition of the two liquids is

    different, but optically, both behave the same.

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    The frequency range for sounds.

    Sound = mechanical longitudinal wave that provoke the auditive sensation

    The sound is characterized by:

    amplitude: the maximal value of elongation

    frequency: the number of periods in time unit (16-20000Hz)

    the propagation (propagation betyder: 3.Physics The act or process of propagating,

    especially the process by which a disturbance, such as the motion of electromagnetic or sound

    waves, is transmitted through a medium such as air or water.) speed

    the intensity - represents the quantity of transported energy that passes in a second through

    the unit of perpendicular surface on the direction of wave propagation. The mechanical waveswith frequency smaller that 16Hz = Infrasounds The mechanical waves with frequency

    greater that 20kHz = ultrasounds

    The Law of the threshold

    For a sound to be able to produce an auditive sensation, its intensity must overpass a certain

    minimal intensity, called the threshold intensity,that varies according to the frequency of the

    sounds. The sounds with the frequency between 1000-5000Hz have the smallest threshold -

    this is the frequency field of current speech. The graphical representation of the threshold ofsound with the frequency is called audiogram.

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    The Law of Weber-Fechner

    If the intensity of the excitant stimulus increases in geometric progression, then the intensity

    of the sensation produced by it increases in arithmetical (Arithmetical betyder: 2. Changingaccording to an arithmetic progression: The increase in the food supply is arithmetic. )

    progression

    Intensity of sound

    For the measurement of the intensity of a sound, two relative units have been introduced:

    The Bel - measures the relative intensity of a sound towards another sound taken as

    reference, of the same frequency

    A decibel is the tenth part of a bel

    The audibility area is between 0-140dB

    The Phon - a sound has the relative intensity of one phon if it is 10 times more intense than

    the sound with the frequency equal to 1000Hz and with the intensity equal to the minimalperceivable threshold

    The choice of the frequency of the standard sound at 1.000Hz is justified by the fact that for

    this frequency there are no age fluctuations of the sensitivity of human hearing

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    Chapter 12 Radiation

    Nuclear radiation, types and characteristics

    The main characteristics of nuclear radiation is that through interaction with the substance

    they produce, directly or indirectly, the ionization of this.

    Different types are Alpha () radiation consists of a fast movinghelium-4 (4

    He) nucleus and is stopped by a sheet of paper. Beta () radiation, consisting ofelectrons, is

    halted by an aluminium plate. Gamma () radiation, consisting of energeticphotons, iseventually absorbed as it penetrates a dense material.

    The law of radioactive disintegration

    Activity, half time and the counting speed

    The interaction of the radiations with substance

    The radiation may interact with

    The electron

    The nucleus

    The coulombian field

    In collision process we may have:

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    Absorbation

    Inelastic scattering

    Elastic scattering of gamma photon

    The attenuation of radiation

    In physics,attenuation (in some contexts also called extinction) is the gradual loss in intensity of anykind offlux through a medium. For instance, sunlight is attenuated by dark glasses,X-raysareattenuated by lead, and lightand sound are attenuated by water.

    Finns inte s mycket mer

    The biological action of radiation:

    - Through direct action: the effect is due to the unmediated action of radiations with sensible

    elements of the biological system

    - Through indirect action: nuclear radiations ionise water and the ionized radicals act

    upon the different molecules from the living substance

    - Through distance action: new relations are formed between the irradiated parts and

    the unirradiated ones

    Biological effects:

    - Somatic effects appear at the irradiated individual

    - Genetic effects appear at the offspring

    For same energy absorbed in the tissue, the particles with higher linear

    ionization (protons, helions) produce stroner biological effects than the particles

    with smaller linear ionization (electrons)

    Relative biological effectiveness (RBE):

    RBE of radiation given towards normal tissue is defined through the ratio

    between the energy absorbed by the tissue at its irradiation with standard

    radiation and the energy absorbed by the tissue at the irradiation with the given

    radiation to produce the same biological, qualitative and quantitative effect.

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    The energy dose (absorbed dose):

    Absorbed dose (D), is the ratio between energy W transferred by the radiations

    to a volume from the irradiated material and mass (m) of the respective volume

    Formeln fr detta r D = W delat med m

    Units: Gray (1GY=1J/kg) or rad (1rad=100erg/g)

    The biological dose:

    B = RBE x D

    Units: rem (-rad) or Sv (Sievert) (-Gy)

    Irradiation sources of the body (Natural, Sanitary, Technical and Variousirradiations):

    Natural irradiation: Is due to the so called radiation background, that containscosmical radiations, the radiations of the radioactive substances from the earths

    surface, from the drinking water, from the building materials, etc.

    0,5 mrem/day or 200mrem/year

    Sanitary irradiation: is due to the use of roentgen radiations for diagnosis andtreatment

    - Lung radiography 0,5 2 rem

    - Dental radiography 2-15 rem

    - Fluoroscopical examination 5 60rem

    - Treatment for malignant tumours 3000 7000 rem

    Technical irradiation or artificial irradiation:Is due to the sources of nuclear radiations created by man after 1940 (radioactive

    sources, accelerators of particles and nuclear reactors used in laboratories forresearch purpose, industry, agriculture, medicine.

    Various irradiations:Wich come from different sources, starting the tv screens, of measuring devices

    and phosphorescent watches and ending with detection systems from the airports

    or in advertising purposes.

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    Classification of territory and population from the point of view ofirradiation risk:

    For the point of view of the irradiation risk, the territory of a country is dividedin:

    - Controlled areas include the spaces of nuclear units, in wich there is therisk for professional irradiation

    - Supervised areas include the areas next to the controlled areas

    - Unsupervised areas the rest of the countrys territory

    From the same point of view, the population of a country is divided in:

    - Professionally irradiated staff(the one who works in controlled areas)

    - Unprofessionally irradiated staff(the one who works in supervisedareas

    - The rest of the population (from unsupervised areas)

    The norms of radioprotection:

    Professionally irradiated staff: Whole body 5rem/year = 50mSv/year, (Hands,legs 75rem/year = 750mSv/year

    Unprofessionally irradiated staff: Whole body 1.5rem/year = 15mSv/year,

    (Hands, legs 7.5rem/year = 75mSv/year

    For the rest of the population: Whole body 0.5rem/year = 5mSv/year, inget fr

    hander ftter.