chapter 1 intro to biophysics

7/21/2019 CHAPTER 1 INTRO TO BIOPHYSICS

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INTRODUCTION TOBIOPHYSICS

Prepared by

Nurdiana Samsulri

zal &Dzulsuhaimi Daud


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LEARNING OUTCOMES

Students will be able to:

Defne the undamental concepts obiophysics.

Understand the integration o physical

theory into biological processes.

Identiy the biophysics tools or biology andhealth industry.


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INTRODUCTION

Understanding biology using some ideasrom physics/chemistry/maths etc.

eed to !now biology in order to dobiophysics.

Using physics to und!st"nd #io$ogy% ot biology to understand physics""


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&HAT IS BIOPHYSICS

#$hysics or biologists%& or #physicalmethods applied to biology%

It is a modern& int!discip$in"!y '$d o

science leading to new approaches or ourunderstanding o biological unctions.

$aradigm: #'iological system is not simplythe sum o its molecular components but israther their unctional integration%

MATHEMATICS + PHYSICS + BIOLOGY + CHEMISTRY


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Bio$ogy "nd )o$cu$"! #io$ogy ,ene regulation& single protein dynamics&

bioenergetics and biomechanics.

St!uctu!"$ #io$ogy

ucleic acid& lipids& carbohydrates and theircomple-es.

Bioin*o!)"tics Se(uence alignment& structural alignment and

protein structure prediction.

Mdicin "nd nu!oscinc embrane permitti+ity& gene therapy

Ph"!)"co$ogy

hannel biology& biomolecular interactions&cellular membranes.

STUDY O+ BIOPHYSICS


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HO& BIOPHYSICS HELPUS(

'iophysics able to e-plain the processas!ed by biologist such as0

1ow do protein old2 1ow are genes turned on and o32 1ow do biomolecules assemble andinteract2

4hat is molecular structure o cellmembrane2

1ow do animals respond to sound andsmell2

1ow do cell mo+e2 1ow does the ner+ous s stem wor!2


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56ray crystallography

uclear agnetic

7esonance

Scanning $robeicroscopy

7ecombinant D8

omputational/imagessystem

HOW DO PROTEIN FOLD?


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NUCLEAR MAGNETIC

RESONANCESPECTROSCOPY


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Synthesize o P!oteins

HOW DO BIOMOLEC"LES

ASSEMBLE AND INTERACT?


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HOW DO BIOMOLEC"LES

ASSEMBLE AND INTERACT?


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APPLICATION O+BIOPHYSICS

,u"ntit"ti- "n"$ysis o the physical andchemical aspect o the unctions o biologicalmolecules and organism.

Tho!tic"$ #iophysics tries to usemathematical and physical models to e-plainlie processes.

In physio$ogic"$ #iophysics& physicalmechanisms ha+e been used to e-plain suchbiological processes as the transmission o

ner+e impulses& the muscle contractionmechanism& and the +isual mechanism.

R"di"tion #iophysicsstudies the response oorganisms to +arious !inds o radiations.


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P"p! ch!o)"tog!"phy& a direct de+elopmento adsorption techni(ues& is widely used toanalyse tissues or chemical components.

./!"y c!yst"$$og!"phy is used to determinemolecular structures and has been useul withsuch problems as the comple- structure o

protein..


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easuring blood pressure bysphyg)o)"no)t!.

Co)put"tion"$ to)og!"phy 0CT1 sc"ntoproduce cross

sectional images../!"y i)"gs widely used in medicine anddentistry to

produce images o the internal structure oob9ects.

U$t!"sound sonog!"phy imaging techni(uethat does

not use ionising radiation instead it utilises highre(uency acoustic +ibrations.


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;luorescencemicroscopy oendothelial cellsusing three labels.

7ed labels themitochondria& greenlabels the ;6actinecytos!eleton andblue labels thenucleus.


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RE2IE&

Physics

M"th)"

tics

Ch)ist!y

BIOLOG

Y$rotein

structure

chapter 1 intro to biophysics

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