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FemaleReproductiveSystemII
Lab22– FemaleReproductiveSystemIIA560– Fall2015
I. IntroductionII. LearningObjectivesIII. SlidesandMicrographs
A. GenitalTract1. Oviduct(Fallopiantube)2. Uterusa. Generalstructureb. Phasesi. Proliferativephaseii. Secretoryphaseiii. Onsetofmenstruation
c. Cervix3. Vagina
B. MammaryGlandIV. Summary
Learning Objectives
1. Identify the layers in the wall of the uterine tube, know the functions ofthe component cells, and recognize the different tubal regions.
2. Recognize the layers of the uterine wall, the functional significance oftheir components, and their changes during the menstrual cycle.
3. Recognize histological feature of the cervix, ectocervix, and vagina.
4. Understand the structure of the mammary gland and how it changesduring puberty, pregnancy, and lactation.
Lab22– FemaleReproductiveSystemIIA560– Fall2015
I. IntroductionII. LearningObjectivesIII. SlidesandMicrographs
A. GenitalTract1. Oviduct(Fallopiantube)2. Uterusa. Generalstructureb. Phasesi. Proliferativephaseii. Secretoryphaseiii. Onsetofmenstruation
c. Cervix3. Vagina
B. MammaryGlandIV. Summary
Keywords
basal layercervixectocervixendometrial glandsendometriumfibrous support tissuefunctional layer
lactiferous ductmammary glandmyoepithelial cellsmyometriumperimetriumuterusvagina
Lab22– FemaleReproductiveSystemIIA560– Fall2015
I. IntroductionII. LearningObjectivesIII. SlidesandMicrographs
A. GenitalTract1. Oviduct(Fallopiantube)2. Uterusa. Generalstructureb. Phasesi. Proliferativephaseii. Secretoryphaseiii. Onsetofmenstruation
c. Cervix3. Vagina
B. MammaryGlandIV. Summary
Lab22– FemaleReproductiveSystemIIA560– Fall2015
I. IntroductionII. LearningObjectivesIII. SlidesandMicrographs
A. GenitalTract1. Oviduct(Fallopiantube)2. Uterusa. Generalstructureb. Phasesi. Proliferativephaseii. Secretoryphaseiii. Onsetofmenstruation
c. Cervix3. Vagina
B. MammaryGlandIV. Summary
Slide60:Oviduct,Ampulla
Slide59:Oviduct,Isthmus
Ovary
Lab22– FemaleReproductiveSystemIIA560– Fall2015
I. IntroductionII. LearningObjectivesIII. SlidesandMicrographs
A. GenitalTract1. Oviduct(Fallopiantube)2. Uterusa. Generalstructureb. Phasesi. Proliferativephaseii. Secretoryphaseiii. Onsetofmenstruation
c. Cervix3. Vagina
B. MammaryGlandIV. Summary
Slide19:Oviduct,MassonTrichrome
serosa
mucosa
muscularis
Lab22– FemaleReproductiveSystemIIA560– Fall2015
I. IntroductionII. LearningObjectivesIII. SlidesandMicrographs
A. GenitalTract1. Oviduct(Fallopiantube)2. Uterusa. Generalstructureb. Phasesi. Proliferativephaseii. Secretoryphaseiii. Onsetofmenstruation
c. Cervix3. Vagina
B. MammaryGlandIV. Summary
Slide19:Oviduct,MassonTrichrome
mucosasimplecolumnarepitheliumandthinlaminapropria
muscularis
serosa
Lab22– FemaleReproductiveSystemIIA560– Fall2015
I. IntroductionII. LearningObjectivesIII. SlidesandMicrographs
A. GenitalTract1. Oviduct(Fallopiantube)2. Uterusa. Generalstructureb. Phasesi. Proliferativephaseii. Secretoryphaseiii. Onsetofmenstruation
c. Cervix3. Vagina
B. MammaryGlandIV. Summary
Slide19:Oviduct,MassonTrichrome
ciliatedcellsciliahelpsweep
fluidtowarduterus
secretorypegcellsnon‐ciliated;secrete
nutritivefilm
laminapropria
Lab22– FemaleReproductiveSystemIIA560– Fall2015
I. IntroductionII. LearningObjectivesIII. SlidesandMicrographs
A. GenitalTract1. Oviduct(Fallopiantube)2. Uterusa. Generalstructureb. Phasesi. Proliferativephaseii. Secretoryphaseiii. Onsetofmenstruation
c. Cervix3. Vagina
B. MammaryGlandIV. Summary
Slide60:Oviduct,Ampulla
Slide59:Oviduct,Isthmus
Examineslides59and60oftheoviducttoidentifythefollowingstructure:
mucosa muscularis serosa
Howdothestructurescomparefromoneslidetotheother?
Lab22– FemaleReproductiveSystemIIA560– Fall2015
I. IntroductionII. LearningObjectivesIII. SlidesandMicrographs
A. GenitalTract1. Oviduct(Fallopiantube)2. Uterusa. Generalstructureb. Phasesi. Proliferativephaseii. Secretoryphaseiii. Onsetofmenstruation
c. Cervix3. Vagina
B. MammaryGlandIV. Summary
Slide1:Uterus,Trichrome
endometrium
myometrium
perimetrium
Lab22– FemaleReproductiveSystemIIA560– Fall2015
I. IntroductionII. LearningObjectivesIII. SlidesandMicrographs
A. GenitalTract1. Oviduct(Fallopiantube)2. Uterusa. Generalstructureb. Phasesi. Proliferativephaseii. Secretoryphaseiii. Onsetofmenstruation
c. Cervix3. Vagina
B. MammaryGlandIV. Summary
endometriummucosawithsimplecolumnarepitheliumandthickunderlyinglaminapropria containingglands
endometrial(uterine)glands
myometrium
Slide1:Uterus,Trichrome
Lab22– FemaleReproductiveSystemIIA560– Fall2015
I. IntroductionII. LearningObjectivesIII. SlidesandMicrographs
A. GenitalTract1. Oviduct(Fallopiantube)2. Uterusa. Generalstructureb. Phasesi. Proliferativephaseii. Secretoryphaseiii. Onsetofmenstruation
c. Cervix3. Vagina
B. MammaryGlandIV. Summary
Slide1:Uterus,Trichrome
perimetriumprimarilyserosa
myometriumendometrium
Lab22– FemaleReproductiveSystemIIA560– Fall2015
I. IntroductionII. LearningObjectivesIII. SlidesandMicrographs
A. GenitalTract1. Oviduct(Fallopiantube)2. Uterusa. Generalstructureb. Phasesi. Proliferativephaseii. Secretoryphaseiii. Onsetofmenstruation
c. Cervix3. Vagina
B. MammaryGlandIV. Summary
functionallayer
basallayer
LayersofEndometrium
myometrium
Lab22– FemaleReproductiveSystemIIA560– Fall2015
I. IntroductionII. LearningObjectivesIII. SlidesandMicrographs
A. GenitalTract1. Oviduct(Fallopiantube)2. Uterusa. Generalstructureb. Phasesi. Proliferativephaseii. Secretoryphaseiii. Onsetofmenstruation
c. Cervix3. Vagina
B. MammaryGlandIV. Summary
MenstrualCycle
1)MenstrualPhaseSlide81
2)ProliferativePhaseSlide80Slide83
3)SecretoryPhaseSlide82Slide84
Lab22– FemaleReproductiveSystemIIA560– Fall2015
I. IntroductionII. LearningObjectivesIII. SlidesandMicrographs
A. GenitalTract1. Oviduct(Fallopiantube)2. Uterusa. Generalstructureb. Phasesi. Proliferativephaseii. Secretoryphaseiii. Onsetofmenstruation
c. Cervix3. Vagina
B. MammaryGlandIV. Summary
Slide80:Endometrium,H&E
myometrium
perimetrium
endometrium
Lab22– FemaleReproductiveSystemIIA560– Fall2015
I. IntroductionII. LearningObjectivesIII. SlidesandMicrographs
A. GenitalTract1. Oviduct(Fallopiantube)2. Uterusa. Generalstructureb. Phasesi. Proliferativephaseii. Secretoryphaseiii. Onsetofmenstruation
c. Cervix3. Vagina
B. MammaryGlandIV. Summary
Slide80:Endometrium,H&E
myometrium
• fewglandsinendometrium• lotsofspacebetweenglands
endometrialglands
Lab22– FemaleReproductiveSystemIIA560– Fall2015
I. IntroductionII. LearningObjectivesIII. SlidesandMicrographs
A. GenitalTract1. Oviduct(Fallopiantube)2. Uterusa. Generalstructureb. Phasesi. Proliferativephaseii. Secretoryphaseiii. Onsetofmenstruation
c. Cervix3. Vagina
B. MammaryGlandIV. Summary
endometrium
myometrium
Slide82:Endometrium,H&E
Lab22– FemaleReproductiveSystemIIA560– Fall2015
I. IntroductionII. LearningObjectivesIII. SlidesandMicrographs
A. GenitalTract1. Oviduct(Fallopiantube)2. Uterusa. Generalstructureb. Phasesi. Proliferativephaseii. Secretoryphaseiii. Onsetofmenstruation
c. Cervix3. Vagina
B. MammaryGlandIV. Summary
Slide82:Endometrium,H&E
• morenumerous,jaggedglands
• presenceofthin‐walled,blood‐filledlacunaeinstroma
vascularlacunae
endometrialglands
Lab22– FemaleReproductiveSystemIIA560– Fall2015
I. IntroductionII. LearningObjectivesIII. SlidesandMicrographs
A. GenitalTract1. Oviduct(Fallopiantube)2. Uterusa. Generalstructureb. Phasesi. Proliferativephaseii. Secretoryphaseiii.Onsetofmenstruation
c. Cervix3. Vagina
B. MammaryGlandIV. Summary
myometriumendometrium
Slide81:Endometrium,H&E
Lab22– FemaleReproductiveSystemIIA560– Fall2015
I. IntroductionII. LearningObjectivesIII. SlidesandMicrographs
A. GenitalTract1. Oviduct(Fallopiantube)2. Uterusa. Generalstructureb. Phasesi. Proliferativephaseii. Secretoryphaseiii.Onsetofmenstruation
c. Cervix3. Vagina
B. MammaryGlandIV. Summary
Slide81:Endometrium,H&E
• bloodinstroma,notinlacunae
• thick,well‐developedfunctionallayer
bloodinstroma
Lab22– FemaleReproductiveSystemIIA560– Fall2015
I. IntroductionII. LearningObjectivesIII. SlidesandMicrographs
A. GenitalTract1. Oviduct(Fallopiantube)2. Uterusa. Generalstructureb. Phasesi. Proliferativephaseii. Secretoryphaseiii. Onsetofmenstruation
c. Cervix3. Vagina
B. MammaryGlandIV. Summary
Slide133:Cervix,H&E
cutedgestratifiedsquamousepithelium
cervicalglands
transitionofepithelium
Lab22– FemaleReproductiveSystemIIA560– Fall2015
I. IntroductionII. LearningObjectivesIII. SlidesandMicrographs
A. GenitalTract1. Oviduct(Fallopiantube)2. Uterusa. Generalstructureb. Phasesi. Proliferativephaseii. Secretoryphaseiii. Onsetofmenstruation
c. Cervix3. Vagina
B. MammaryGlandIV. Summary
Slide133:Cervix,H&E
endocervical gland
ectocervix
Lab22– FemaleReproductiveSystemIIA560– Fall2015
I. IntroductionII. LearningObjectivesIII. SlidesandMicrographs
A. GenitalTract1. Oviduct(Fallopiantube)2. Uterusa. Generalstructureb. Phasesi. Proliferativephaseii. Secretoryphaseiii. Onsetofmenstruation
c. Cervix3. Vagina
B. MammaryGlandIV. Summary
Slide108:MammaryGland,H&E
secretoryacini(lobule)
lobuleconsistsofmultipleacinialldrainingtosame
terminalduct
fibrousinterlobularsupporttissue
adipose
Lab22– FemaleReproductiveSystemIIA560– Fall2015
I. IntroductionII. LearningObjectivesIII. SlidesandMicrographs
A. GenitalTract1. Oviduct(Fallopiantube)2. Uterusa. Generalstructureb. Phasesi. Proliferativephaseii. Secretoryphaseiii. Onsetofmenstruation
c. Cervix3. Vagina
B. MammaryGlandIV. Summary
Slide108:MammaryGland,H&E
lactiferousduct
secretoryacini(lobules)
fibroussupporttissue
Lab22– FemaleReproductiveSystemIIA560– Fall2015
I. IntroductionII. LearningObjectivesIII. SlidesandMicrographs
A. GenitalTract1. Oviduct(Fallopiantube)2. Uterusa. Generalstructureb. Phasesi. Proliferativephaseii. Secretoryphaseiii. Onsetofmenstruation
c. Cervix3. Vagina
B. MammaryGlandIV. Summary
Slide108:MammaryGland,H&E
plasmacells
myoepithelialcell insidebasementmembranesecretoryaciniandductsarebothcomposedoftwolayersofcells:theluminalepithelialcellsandthebasalmyoepithelialcells
Lab22– FemaleReproductiveSystemIIA560– Fall2015
I. IntroductionII. LearningObjectivesIII. SlidesandMicrographs
A. GenitalTract1. Oviduct(Fallopiantube)2. Uterusa. Generalstructureb. Phasesi. Proliferativephaseii. Secretoryphaseiii. Onsetofmenstruation
c. Cervix3. Vagina
B. MammaryGlandIV. Summary
Common Confusion:Seminal vesicle vs. Ampulla (of Oviduct)
Seminal Vesicle
Seminal vesicle: secretory gland of male reproductivetract, producing majority of seminal fluid volume; consistsof single tube coiled upon itself; joins with vas deferens toform ejaculatory duct
Look for: (1) glandular with the appearance of multiplelumens as result of coiling of tube; (2) highly‐foldedmucosa, often having fine “honeycomb” appearance; (3)non‐ciliated pseudostratified columnar epithelium withlipid droplets in cytoplasm giving “foamy” appearance; (4)lipofuscin pigment is often seen in mucosa
Ampulla of oviduct (uterine tube, Fallopian tube, orsalpinx): tube leading from ovary to uterus; tube transmitsovum to uterus and is the usual site of fertilization, usuallyin the ampulla
Look for: (1) single lumen tube w/ mucosa surrounded bymuscularis and serosa continuous with broad ligament; (2)mucosal folds often appear “thicker” than in seminalvesicle due to more lamina propria in the folds; (3) ciliatedsimple columnar epithelium and non‐ciliated “peg cells”present in mucosa; (4) size of muscularis changes withregion of oviduct, generally thin in ampulla and thick inisthmusOviduct
Time (Days) of Cycle Influencing Hormones Thickness of Endometrium Endometrial Glands Vasculature
Proliferativephase
Secretory phase
Menstrualphase
Lab22‐ Characteristicsofuterinewallthroughoutmenstrualcycle
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