who activities on influenza vaccine research

WHO activities on influenza vaccine research

Dr John S. Tam

Technical Officer

Initiative for Vaccine Research

Immunization, Vaccines and Biologicals

GAP-II: Further Research and Development | 13 July 2011, Geneva2 |

WHO Public health research agenda for influenza

1st Consultative meeting in 2009

WHO Public health research agenda for influenza

1st Consultative meeting in 2009


WHO Documents Highlighting The Importance of Research in Influenza

WHO Documents Highlighting The Importance of Research in Influenza


Influenza Research Priorities in Other Agencies and Organizations

Influenza Research Priorities in Other Agencies and Organizations


GOAL:

Support the development of evidences needed to strengthen

public health guidance and actions essential for limiting the

impact of influenza on individuals and populations

WHO Public health research agenda for influenzaWHO Public health research agenda for influenza

Stream 1. Reducing risk of emergence of pandemic

influenza

Stream 2. Limiting spread of pandemic, zoonotic and seasonal influenza

Stream 3. Minimizing impact of pandemic, zoonotic and seasonal influenza

Stream 4. Optimizing treatment of patients

Stream 5. Promoting development and application of

modern public health tools in influenza control

http://www.who.int/csr/disease/influenza/research_agenda/en/


Public Health Research Agenda for Influenza Stream 1. Reducing the risk of emergence of pandemic influenza

Public Health Research Agenda for Influenza Stream 1. Reducing the risk of emergence of pandemic influenza

Research Recommendations:

• Factors associated with the emergence of influenza viruses with zoonotic or pandemic potential

• Factors associated with human infection at the human-animal interface

• Preventive measures and surveillance at the human-animal interface


Public Health Research Agenda for Influenza Stream 2. Limiting the spread of influenza

Public Health Research Agenda for Influenza Stream 2. Limiting the spread of influenza

Research Recommendations :

• Factors associated with person-to-person

transmission

• Non-medical measures to limit transmission

• Dynamics of virus spread at global and local levels



• Determining disease burden and social impact

• Improve immunogenicity, availability and delivery of influenza vaccines

• Public health policies to reduce the impact of disease

Public Health Research Agenda for Influenza Stream 3. Minimizing the impact of influenza

Public Health Research Agenda for Influenza Stream 3. Minimizing the impact of influenza



• Factors associated with pathogenesis and clinical

severity

• Improve clinical management of patients

• Health care capacity and response

Public Health Research Agenda for Influenza Stream 4. Optimizing the treatment of patients

Public Health Research Agenda for Influenza Stream 4. Optimizing the treatment of patients



• Modern tools for early detection and disease monitoring/surveillance

• Role of modelling in public health decision making

• Modern tools for strategic communication

Public Health Research Agenda for Influenza Stream 5. Development & application of modern public health tools

Public Health Research Agenda for Influenza Stream 5. Development & application of modern public health tools



• Assessment of disease burden� Disease burden for epidemic influenza (developing regions, morbidity &

mortality by age and epidemiological settings)� Using disease burden data for health resource utilization planning

• Pharmacological interventions to reduce impact of disease� Development of new-generation vaccines (immunogen design, new

formulation, use of adjuvants)� Evaluation of vaccines� Increased pandemic vaccine production capacity � Development and evaluation of new antiviral drugs � Enhancing antiviral drug production capacity

• Public health policies to reduce impact of disease� Best practices for under-resourced countries� Social, ethical & legal considerations in public health policies development

Public health research agenda for influenza Stream 3. Minimizing the impact of influenza

Public health research agenda for influenza Stream 3. Minimizing the impact of influenza


Initiative for Vaccine Research (IVR)Initiative for Vaccine Research (IVR)

� Vaccine research and development monitoring

� Policy development research

� Operational research

� Implementation research

� Regulatory research

� Research agenda development


Landscaping on vaccine research and development:

� Annual meeting on Evaluation of Pandemic Influenza Vaccines in

Clinical Trials (7th meeting held on 17 - 18 February 2011 )

http://www.who.int/vaccine_research/diseases/influenza/flu_trials_tables/en/index.html

� Annual meeting on influenza vaccines that induce broad spectrum

and long-lasting immune responses (5th meeting to be held on 16-17

November 2011, Geneva) http://www.who.int/vaccine_research/diseases/ari/Influenza_meetings/en/

� Database on influenza vaccine clinical trial results for public

access through internet (http://www.who.int/vaccine_research/diseases/influenza/flu_trials_tables/en/index.html)

� Continued monitoring of global vaccine pipelines development

Vaccine Research and DevelopmentVaccine Research and Development


Global road-mapping for vaccination policy development and coverage - follow up actions:

� Develop regional workshops for vaccine policy development with all regional offices

� Continued monitoring of vaccine policy implementation and coverage

� Continued updates on acceptance and use of vaccines

� Monitor evidence supporting the use of adjuvanted vaccines and their safety

� Monitor evidence to support and review SAGE recommendations for influenza vaccine

Policy DevelopmentPolicy Development


� Research on optimum vaccine deployment strategy

� Identify optimum strategies for pandemic vaccine

stockpile management

Operational ResearchOperational Research


� Initiate and support vaccine effectiveness studies in

developing countries especially for grantee countries

� Initiate and support vaccine cost-effectiveness studies

especially for countries/regions developing vaccine

policies for influenza

Implementation ResearchImplementation Research


� Identify country-specific regulatory approval issues associated with influenza vaccine development particularly in grantee

countries

� Facilitate exchange of information on comparison of country-

specific regulatory approval issues associated with influenza vaccine and vaccine policy development

� Examine options for harmonization of regulatory requirements forinfluenza vaccines

� Develop regulatory pathways for novel influenza vaccine licensing

� Monitor and initiate research on correlates of protection in various influenza vaccines

Regulatory ResearchRegulatory Research


� Organize consultative meeting to develop Influenza Vaccine

Research Agenda and identify priority research areas on novel vaccine targets, production platforms, formulation and vaccine

delivery methods (SAGE WG)

� Develop plans and provide support for priority vaccine research

areas identified in the Research Agenda

� Align and support activities in the WHO Public Health Research

Agenda for Influenza (GIP)

Research Agenda for

Influenza Vaccine

Research Agenda for

Influenza Vaccine


Current ContextCurrent Context

IHR RC PIP

GAP

TechTransfer

R&D

VaccineVaccine

Antivirals

Diagnostics

Virus sharingSurveillance

Preparedness

Research agenda

Responds