gsk influenza virus vaccine
DESCRIPTION
GlaxoSmithKline (GSK) is one of the world’s largest research based pharmaceutical corporation that discover, develops, manufactures and markets branded health care products. GSK mission is to improve the quality of human life by enabling people to do more, feel better and live longerTRANSCRIPT
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Influenza Virus Vaccine
Presented by: Mahak Ajmera
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Contents
Company Introduction
Health Care Portfolio
Influenza Virus
Products
Vaccine Development Process
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GlaxoSmithKline
World largest research based pharmaceutical corporation that discover, develops, manufactures and markets branded health care products.
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2012
Source:http://www.gsk.com/content/dam/gsk/globals/documents/pdf/GSK-Annual-Report-2012.pdf
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Key Facts
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GlaxoSmithKline - Mission
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GlaxoSmithKline - Where they are?
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GSK - Turnover
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Source:http://www.gsk.com/content/dam/gsk/globals/documents/pdf/GSK-Annual-Report-2012.pdf
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Healthcare Portfolio
Pharmaceuticals
Infectious diseases
Cancer
Epilepsy
Heart Disease
Asthma and chronic pulmonary disease
AIDS
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Vaccines
Hepatitis A and B
Diphtheria, Tetanus, Whooping cough
Polio
Measles, Mumps, Rubella
Typhoid
Influenza
Bacterial meningitis
Consumer
Healthcare
Oral Care
Nutritional
Total wellness
Skin Health
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Healthcare Portfolio
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Source:http://www.gsk.com/content/dam/gsk/globals/documents/pdf/GSK-Annual-Report-2012.pdf
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GlaxoSmithKline Vaccines – Market Share
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Source: http://who.int/influenza_vaccines_plan/resources/session_10_kaddar.pdf
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Influenza
Influenza (the flu) contagious respiratory disease caused by influenza viruses.
Affect the respiratory track (nose, throat and lungs).
Symptoms : fever, headache, malaise, cough, sore throat, nasal congestion and body aches.
10% to 20% of the population is infected with influenza virus each year
It can cause to severe illness and at times lead to death.GSK - Influenza Virus Vaccine 12/3/2014 11
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Types of Influenza Virus
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Sr. No
Basis Type A Type B Type C
1 Symptoms Moderate to Severe Mild Mild
2 Age Group All Primarily children All
3 Affect Humans and animal Affects human only
Affects human only
4 Divided Subdivided based on antigenic differences
Not divided intosub types
Not divided into sub types
5 Epidemics Widespread Regional Don’t cause
6 Experienced Mostly Less Common than type A
RarelyReported
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Influenza A Virus
Is subdivide into two distinct large surface glycoprotein's antigens.
H- Haemagglutinin which initiates infection and attachment of virus to the susceptible cell
N- Neuraminidase which is responsible for release of virus from the infected cell
Mutations in the antigenic structure of the influenza virus have resulted in a number of different influenza subtypes and strains (antigenic drift)
H Type (1-15) and N Type (1-9)
Only H1, H2 and H3 and N1, N2 are found in humans.
Example: H1N1,H2N2,H3N2 etc.
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Source: Karl G Nicholson, John M Wood, Maria Zambon, THE LANCET • Vol 362 • November 22, 2003 • www.thelancet.com
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Influenza Virus
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Source: http://en.wikipedia.org/wiki/File:InfluenzaNomenclatureDiagram.svg
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Influenza Outbreak
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Types of Influenza Vaccines
Inactivated Vaccine (Killed)
• These type of vaccine are produced by killing the virus with chemicals, heat or radiation.
• There are three types of inactivated vaccine whole virus, split virus and subunit vaccine.
• They are generally injected (intramuscular).
Live Attenuated Vaccine
• The vaccine contain a version of weakened strain of virus.
• They are given intranasal.
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Fluarix
Suspension for injection supplied in 0.5-mL single-dose prefilled syringes
Composition:
• A/Christchurch/16/2010 (H1N1)
• A/Texas/50/2012 (H3N2)
• B/Massachusetts/2/2012
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Source: https://www.gsksource.com/gskprm/en/US/adirect/gskprm?cmd=ProductDetailPage&product_id=1244169218783&featureKey=600572
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Fluarix Quadrivalent
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Suspension for injection supplied in 0.5-mL single-dose prefilled syringes
Composition:
• A/Christchurch/16/2010 (H1N1)
• A/Texas/50/2012 (H3N2)
• B/Brisbane/3/2007
• B/Brisbane/60/2008
Source: https://www.gsksource.com/gskprm/en/US/adirect/gskprm?cmd=ProductDetailPage&product_id=1358783243411&featureKey=603902
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FluLaval
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Supplied in a 5-mL multi-dose vial containing 10 doses (0.5-mL each)
Composition:
• A/California/7/2009 (H1N1)
• A/Texas/50/2012 (H3N2)
• B/Massachusetts/2/2012
Source: https://www.gsksource.com/gskprm/en/US/adirect/gskprm?cmd=ProductDetailPage&product_id=1244169337831&featureKey=600581
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FluLaval Quadrivalent
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Supplied in a 5-mL multi-dose vial containing 10 doses (0.5 mL each)
Composition:
• A/California/7/2009 (H1N1)
• A/Texas/50/2012 (H3N2)
• B/Massachusetts/2/2012
• B/Brisbane/60/2008
Source:https://www.gsksource.com/gskprm/en/US/adirect/gskprm?cmd=ProductDetailPage&product_id=1378227924542&featureKey=604242
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Pandemrix
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For influenza pandemic (H1N1) also know as swine flu
Supplied as suspension to be mixed with emulsion adjuvant (AS03) before injection
Composition:
• A/California/7/2009 (H1N1)
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GSK Flu Vaccine Development Process
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Source: http://www.gsk.com/content/dam/gsk/globals/documents/pdf/GSK-Flu-Vaccine-Production-Process.pdf
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GSK Flu Vaccine Development Process
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GSK Flu Vaccine Development Process
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GSK Flu Vaccine Development Process
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References
http://www.gsk.com/about-us/what-we-do.html
http://www.gsk.com/products/our-vaccines.html
https://www.gsksource.com/gskprm/en/US/adirect/gskprm?cmd=ProductsByName#F
http://www.gsk.com/content/dam/gsk/globals/documents/pdf/GSK-Annual-Report-2012.pdf
http://www.gsk.com/content/dam/gsk/globals/documents/pdf/GSK-Flu-Vaccine-Production-Process.pdf
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