white lesions
TRANSCRIPT
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Classification(Burket’s classification):HEREDITARY WHITE LESIONSLeukoedemaWhite Sponge NevusHereditary Benign Intraepithelial
DyskeratosisDyskeratosis Congenita
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REACTIVE/INFLAMMATORY WHITE LESIONSLinea Alba (White Line)Frictional (Traumatic) KeratosisCheek ChewingChemical Injuries of the Oral MucosaActinic Keratosis (Cheilitis)Smokeless Tobacco–Induced KeratosisNicotine StomatitisSanguinaria-Induced Leukoplakia
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INFECTIOUS WHITE LESIONS AND WHITE ANDRED LESIONS
Oral Hairy LeukoplakiaCandidiasisMucous PatchesParulis
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Classification cont.…IDIOPATHIC “TRUE” LEUKOPLAKIABOWEN’S DISEASEERYTHROPLAKIAORAL LICHEN PLANUSLICHENOID REACTIONSLUPUS ERYTHEMATOSUS (SYSTEMIC AN DISCOID)DEVELOPMENTAL WHITE LESIONS: ECTOPIC
LYMPHOID TISSUE FORDYCE’S GRANULESGINGIVAL AND PALATAL CYSTS OF THE NEWBORN
AND ADULTMISCELLANEOUS LESIONS
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HEREDITARY WHITE LESIONS
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LEUKOEDEMADiffuse grayish-
white milky appearance of the buccal mucosa
Appearance will disappear when cheek is everted and stretched
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TREATMENT
No treatment is indicated for leukoedema since it is a variation of the normal condition.
No malignant change has been reported
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White spongy nevusWhite sponge nevus (WSN) is a rare
autosomal dominant disorder.With a high degree of penetrance and
variable expressivity.It predominantly affects noncornified
stratified squamous epithelium.
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Presents as bilateral symmetric white, soft, “spongy,” or velvety thick plaques of the buccal mucosa.
Other sites in the oral cavity may be involved, including the ventral tongue, floor of the mouth, labial mucosa, soft palate, and alveolar mucosa.
Clinical features of white spongy nevus
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TREATMENT
No treatment is indicated for this benign and asymptomatic condition.
if the condition is symptomatic Patients may require palliative treatment.
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REACTIVE AND INFLAMMATORYWHITE LESIONS
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Linea Alba (White Line)Is a horizontal
streak on the buccal mucosa at the level of the occlusal plane.
It is a very common finding most likely associated with pressure, frictional irritation, or sucking trauma from the facial surfaces of the teeth.
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Frictional (Traumatic) KeratosisIs defined as a white plaque with a rough and
frayed surface that is clearly related to an identifiable source of mechanical irritation
Usually resolve on elimination of the irritant.
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TREATMENT
Upon removal of the offending agent, the lesion should resolve.
within 2 weeks. Biopsies should be performed on lesions that do not heal to rule out a dysplastic lesion.
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Cheek bitingRagged, irregular white tissue of the
buccal mucosa in the line of occlusionMay be ulceratedDue to chewing or biting the cheeksMay also be seen on labial mucosa
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TREATMENT AND PROGNOSIS
Since the lesions result from an unconscious and/or nervous habit, no treatment is indicated.
For those desiring treatment and unable to stop the chewing habit, a plastic occlusal night guard may be fabricated.
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Chemical Injuries of the Oral MucosaTransient nonkeratotic white lesions of the oral
mucosa .Are often a result of chemical injuries caused by a
variety of caustic agents retained in the mouth for long periods of time.
such as aspirin, silver nitrate, formocresol, sodium hypochlorite, paraformaldehyde, dental cavity
varnishes, acid etching materials, and hydrogen peroxide.
18
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The white lesions are attributable to the formation of a superficial pseudomembrane composed of a necrotic surface tissue and an inflammatory exudates.
Aspirin burn, creating a pseudomembranous necroticwhite area.
Chemical Injuries of the Oral Mucosa
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Extensive tissue necrosis caused by injudicious use of nitrate silver
Chemical Injuries of the Oral Mucosa
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Severe ulceration and sloughing of mucosa, caused by use of a cinnamon-containing dentifrice
Chemical Injuries of the Oral Mucosa
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Actinic Keratosis (Cheilitis)
Actinic (or solar) keratosis is a premalignant epithelial lesion directly related to long-term sun exposure
classically found on the vermilion border of the
lower lip as well as on other sun-exposed areas of the skin.
A small percentage of these lesions will transform into squamous cell carcinoma.
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ACTINIC CHEILITIS
Distinctive raised white plaque, representing actinic cheilitis.
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Nicotine StomatitisNicotine StomatitisPalate initially becomes diffusely
erythematous and eventually turns grayish white secondary to hyperkeratosis
multiple keratotic papules with depressed red centers correspond to dilated and inflamed excretory duct openings of the minor salivary glands
Palate initially becomes diffusely erythematous and eventually turns grayish white secondary to hyperkeratosis
multiple keratotic papules with depressed red centers correspond to dilated and inflamed excretory duct openings of the minor salivary glands
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Nicotinic stomatitis
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, Histologicappearance of nicotine stomatitis, showing hyperkeratosis and acanthosiswith squamous metaplasia of the dilated salivary duct. (Hematoxylin andeosin, ×40 original magnification)
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TREATMENT AND PROGNOSIS
Nicotine stomatitis is completely reversible once the habit is discontinued.
The lesions usually resolve within 2 weeks of cessation of smoking.
Biopsy of nicotine stomatitis is rarely indicated except to reassure the patient.
biopsy should be performed on any white lesion of
the palatal mucosa that persists after month of discontinuation of smoking habit
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Oral CandidiasisOccurs in persons with poorly controlled
diabetes, pregnancy, hormone imbalance, those receiving broad spectrum antibiotics, long term steroid treatment, cancer therapy and other immunocompromised individuals
Oral lesions may be erythematous, pseudomembranous, hyperplastic or angular cheilitis
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Classification of Oral CandidiasisAcutePseudomembranousAtrophic (erythematous)Antibiotic stomatitisChronicAtrophicDenture sore mouthAngular cheilitisMedian rhomboid glossitis
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Hypertrophic/hyperplasticCandidal leukoplakiaPapillary hyperplasia of the palate (see denture
sore mouth)Median rhomboid glossitis (nodular)MultifocalMucocutaneousSyndrome associatedFamilial +/– endocrine candidiasis syndromeMyositis (thymoma associated)LocalizedGeneralized (diffuse)Immunocompromise (HIV) associated
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Clinical featuresDiffuse, patchy, or globular white thickened
plaques on the tongue, soft palate & buccal mucosa.
Can be wiped off erythematous, atrophic, or, ulcerated mucosa.
Mild burning pain severe when coagulum scraped.
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11--Pseudomembranous CandidiasisPseudomembranous CandidiasisAcute superficial mucosal infection. Infants & immune compromised.systemic corticosteroid therapy,
chemotherapy, AIDS, or acute debilitating illness.
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Pseudomembranous candidiasis on the palate.
Oral Candidiasis/Acute
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A patient with a history of chronic iron deficiency anemia developed red, raw, and painful areas of the mucosa, diagnosed as acute atrophic candidiasis.
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More-extensive pseudomembranous lesions associated with an erythematous base in an adult with severe thrush .
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Chronic mucocutaneous candidiasis: multiple lesions on the tongue
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Chronic candidiasis AtrophicDenture sore mouthAngular cheilitisMedian rhomboid glossitis
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Denture sore mouth
Denture stomatitis is a common form of oral candidiasis111
Manifests as a diffuse inflammation of the maxillary denture-bearing areas .
and that is oOften associated with angular cheilitis.
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progressive stages of denture sore mouth .
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Angular cheilitis is the term used for an infection involving the lip commissures.
The majority of cases are Candida associated and respond promptly to antifungal therapy.
There is frequently a coexistent denture stomatitis.
Streptococcus.
Angular cheilitis
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Other possible etiologic cofactors include reduced vertical dimensionnutritional deficiency (iron deficiency anemia
and vitamin B or folic acid deficiency) sometimes referred to as perlèche;
diabetes, neutropenia, and AIDS.co-infection with Staphylococcus and beta-
hemolytic streptococcus.
Angular cheilitis
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Erythematous patches of atrophic papillae located in the central area of the dorsum of the tongue
Considered a form of chronic atrophic candidiasis
These lesions were originally thought to be developmental in nature but are now considered to be a manifestation of chronic candidiasis.
Median Rhomboid glossitis
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Chronic hyperplastic candidiasisCandidal leukoplakiaPapillary hyperplasia of the palate
(denture sore mouth)Median rhomboid glossitis (nodular)
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Hyperplastic candidiasisSuperficial infection of the oral mucosa by the fungus Candida albicans and less common species of the same genus.
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Hyperplastic candidiasisPredisposing factors, poor oral hygiene,xerostomia, recent antibiotic
treatment,dental appliance Compromised Immune
system. early infancyAIDSCorticosteroidanemia,diabetes mellitus
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Chronic mucocutaneous candidiasisSyndrome associated Familial +/– endocrine candidiasis
syndrome Myositis (thymoma associated)LocalizedGeneralized (diffuse
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Chronic mucocutaneous candidiasis
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Candidiasis- TreatmentMild to Moderate- Topical Therapies
Nystatin (suspension 100KU/mL, or 1% cream), Clotrimazole (troche, 10mg)
Moderate to Sever- Systemic TherapiesFluconazole (100mg/day), Itraconzole (oral suspension 10mg/mL)
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Candidiasis TreatmentTopical therapy with nystatin or clotrimazole
is effective. Treatment length is usually 10-14 days, follow up
Clotrimazole 10mg, 1 tab 5x/day, dissolve slowly and swallow, 10 day treatment
Systemic treatment with fluconazole 100 mg/day for 10 days for oropharyngeal/esophageal disease, follow up
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References:Burket’s Oral Medicine ,Diagnosis & Treatment
2003 BC Decker Inc Tenth EditionGeorge Laskaris, Pocket Atlas of Oral
Diseases, 2nd edition, 2006, Stuttgart · New York