Transcranial Magnetic Stimulation (TMS) Peter P. Ricci Biomedical Engineering BME 281 Section 1.

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<ul><li><p>Transcranial Magnetic Stimulation (TMS)Peter P. RicciBiomedical EngineeringBME 281 Section 1</p></li><li><p>BackgroundDepressionAffects 350 million people on a daily basis</p><p>The leading cause of disability worldwide and a major contributor to the global number of mental disorders</p><p>Can develop at any age, but has a median onset of 35 years old</p></li><li><p>IntroductionTMS is the process of using a magnetic generator to stimulation the brain cells that control mood</p><p>Early clinical implementation has shown the ability to treat the effects of major brain damage and mental disorders </p><p>Neurological DisordersStroke symptomsDepressionMotor neuron disease</p></li><li><p>ProcessA magnetic field generator, or coil, is placed near the desire part to the brain</p><p>The coil then produces electric currents just above the head </p><p>The coil is attached to a pulse generator, which alternates the flow of the electric currents </p><p>The currents stimulate the neurons of the limbic system to control mood </p></li><li><p>Chervyakov, Alexander. Possible mechanisms underlying the Therapeutic effects of transcranial magnetic stimulation. Frontiers in human neuroscience 2015; 9: 303. Jun 16 2015</p></li><li><p>Clinical StudyResearch comprised of 24 drug resistant patients that were diagnosed with recurrent major depressive disorder</p><p>Patients received daily TMS treatments for 4 weeks</p><p>Patients were then split into two groups in which one received continual maintenance over a 12 month period while the other only received the initial treatment</p></li><li><p>ResultsResults displayed a significant reduction in HDRS scores for all patients involved Patients receiving follow-up maintenance showed even greater improvements</p></li><li><p>ResultsRapinesi, Chiara. Maintenance Deep Transcranial Magnetic stimulation sessions are associated with reduced depressive relapses Frontiers in Neurology 2015: 9: 16. Feb 6 2015</p><p>Patients with TMS Maintenance Patients without TMS MaintenanceBaseline HDRS23.8323.50Post TMS HDRS9.839.926 month follow-up9.3313.7512 month follow-up12.9216.17</p></li><li>Advantages &amp; DisadvantagesBlackHawk TMS </li><li><p>Future ImplementationResearch into the effects of debilitating brain injuriesi.e. stroke &amp; motor neuron disease</p><p>Treatment for numerous mental disordersHopefully a sustainable cure for depression </p></li><li><p>Questions?</p></li><li><p>ReferencesChervyakov, Alexander. Possible mechanisms underlying the Therapeutic effects of transcranial magnetic stimulation. Frontiers in human neuroscience 2015; 9: 303. Jun 16 2015</p><p>Wikipedia: transcranial magnetic stimulation .</p><p>Rapinesi, Chiara. Maintenance Deep Transcranial Magnetic stimulation sessions are associated with reduced depressive relapses Frontiers in Neurology 2015: 9: 16. Feb 6 2015</p><p>BlackHawk TMS </p></li></ul>

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