April 9

12:30 ARRIVAL, REGISTRATION and LUNCH

14:00 OPENING REMARKS Organizing committee

14:15 SESSION I: Nerves in cancer Chair: Daniel Öhlund

How the central and peripheral nervous systems regulate cancer development? Claire Magnon

Short talks Alessandro Mega (abstract 1) Elisa Stellaria Grassi (abstract 2) Tracy Berg (abstract 4)

15:30 FIKA and POSTERS

16:00 SESSION II: Chair: Daniel Öhlund

The Microbiome and cancer

The Tumor Microbiome and its Influence on Chemoresistance Leore Geller

Short talk Teresa Frisan (abstract 6)

Targeting cancer

Short talk Ya-Fang Mei (abstract 8)

Developmental pathways and mechanisms

Short talk Milena Petkova (abstract 9)

17:15 SESSION III: New technology and methods to study the microenvironment (Part 1) Chair: Arne Östman Representatives from SciLifeLab Precision Cancer Medicine - beyond genomics Päivi Östling

Characterizing intra-tumoral heterogeneity using in situ sequencing Mats Nilsson

Seeing is believing, measuring is knowing' - quantitative analysis in digital pathology Carolina Wählby

18:30 MINGLE DINNER and POSTERS

April 10

08:30 SESSION IV: Cancer-associated fibroblasts and ECM in cancer Chair: Malin Sund

Role of stromal heterogeneity in immunosupression and metastatic spread in breast cancers Fatima Mechta-Grigoriou

Short talks Annika Nordstrand (abstract 11) Elena Garre (abstract 13) Laia Gorchs (abstract 17) Mercedes Herrera (abstract 19)

10:00 FIKA and POSTERS

10:30 CONT. SESSION IV: Environmentally defined clonogenicity in colon cancer Louis Vermeulen

Short talks Rainer Heuchel (abstract 21) Sofia Halin Bergström (abstract 23) Tommy Lidström (abstract 25) Justin Vareecal Joseph (26)

12:00 LUNCH

13:30 SESSION V: Immune cells and cancer Chair: Kristian Pietras

Mechanism of T cell-mediated tumor rejection Thomas Blankenstein

Short talks Andreas Lundqvist (abstract 27) Artur Mezheyeuski (abstract 28) Sara Corvigno (abstract 29) Susanna Cardell (abstract 30)

15:00 FIKA and POSTERS

16:45 SESSION VI: The vasculature in cancer and beyond Chair: Taija Mäkinen

Tumor-vessel interactions during tumor progression and metastasis Hellmut Augustin

Short talks Elin Sjöberg (abstract 32) Mia Phillipson (abstract 33) Soniya Savant Botla (abstract 35) Ulf Eriksson (abstract 36) Per Larsson (abstract 37)

18:30 CONFERENCE BANQUET

April 11

09:00 SESSION VII: New technology and methods to study the microenvironment (Part 2) Chair: Arne östman Immune-Humanized Mouse Models of Solid Cancer Jonas Nilsson

Short talks Cedric Patthey (abstract 38) Leslie Solorzano (abstract 39) Olga Surova (abstract 40) Andreas Svanström (abstract 41) Emmy Borgmästars (abstract 42)

10:45 FIKA and POSTERS

11:15 SESSION VIII: Clinical trials Chair: Daniel Öhlund

An overview of the clinical development program of Pegvorhyaluronidase Alfa (PEGPH20) Kasia Nej-Wolosiak

11:40 CONCLUDING REMARKS Anders Bergh and Organizing committee

12:00 BOX LUNCH and DEPARTURE

I

The Swedish Tumor Microenvironment Meeting 2019 Umeå Folkets Hus, Sweden – April 9-11

version 2019-04-10

II

III

VI

V

VI

VII

VIII