the role of chondrocyte senescence in the pathogenesis of osteoarthritis and in limiting cartilage...

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The Role of Chondrocyte Senescence in the Pathogenesis of Osteoarthritis and in Limiting Cartilage Repair by James A. Martin, and Joseph A. Buckwalter J Bone Joint Surg Am Volume 85(suppl 2):106-110 April 1, 2003 ©2003 by The Journal of Bone and Joint Surgery, Inc.

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Page 1: The Role of Chondrocyte Senescence in the Pathogenesis of Osteoarthritis and in Limiting Cartilage Repair by James A. Martin, and Joseph A. Buckwalter

The Role of Chondrocyte Senescence in the Pathogenesis of Osteoarthritis and in Limiting Cartilage Repair

by James A. Martin, and Joseph A. Buckwalter

J Bone Joint Surg AmVolume 85(suppl 2):106-110

April 1, 2003

©2003 by The Journal of Bone and Joint Surgery, Inc.

Page 2: The Role of Chondrocyte Senescence in the Pathogenesis of Osteoarthritis and in Limiting Cartilage Repair by James A. Martin, and Joseph A. Buckwalter

Results of linear regression analysis of chondrocytes from donors of ranging in age from one to eighty-seven years.

James A. Martin, and Joseph A. Buckwalter J Bone Joint Surg Am 2003;85:106-110

©2003 by The Journal of Bone and Joint Surgery, Inc.

Page 3: The Role of Chondrocyte Senescence in the Pathogenesis of Osteoarthritis and in Limiting Cartilage Repair by James A. Martin, and Joseph A. Buckwalter

Ethidium bromide-stained agarose gel showing the products of long-distance polymerase chain reaction amplification of the mitochondrial genome at five, twelve, eighteen, and twenty-three

population doublings.

James A. Martin, and Joseph A. Buckwalter J Bone Joint Surg Am 2003;85:106-110

©2003 by The Journal of Bone and Joint Surgery, Inc.