the future of neurosurgery - university of utah school of ... · las vegas denver phoenix...
TRANSCRIPT
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Clinical Neurosciences CenterDepartment of Neurosurgery
SURGICAL
NEUROREHABILITATION
Mark A. Mahan, MDAssistant Professor
Dept. of Neurosurgery
University of Utah
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Clinical Neurosciences CenterDepartment of Neurosurgery
MARK A. MAHAN, MD
• Undergraduate: Princeton University
• Medical school: Columbia University
• Neurosurgical residency: Barrow
• Infolded fellowship in peripheral nerve
surgery (AANS/CNS Cahill Award)
– Robert Spinner MD at Mayo Clinic, Rochester
– Justin Brown MD at UCSD
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Clinical Neurosciences CenterDepartment of Neurosurgery
WHY I CAME TO THE
UNIVERSITY OF UTAH
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Clinical Neurosciences CenterDepartment of Neurosurgery
ACADEMIC NEUROSURGEONS WITH
PERIPHERAL NERVE PRACTICESSeattle
Salt Lake City
Las Vegas
Denver
Phoenix
Albuquerque
Kansas City
Dallas
OKC
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Clinical Neurosciences CenterDepartment of Neurosurgery
ACADEMIC NEUROSURGEONS WITH
PERIPHERAL NERVE PRACTICES
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Clinical Neurosciences CenterDepartment of Neurosurgery
PERIPHERAL NERVE TERRITORY
• Peripheral nerve tumors
• Entrapment neuropathies
• Pain
• Reconstruction
• Functional
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Clinical Neurosciences CenterDepartment of Neurosurgery
PERIPHERAL NERVE TERRITORY• Peripheral nerve tumors
– Benign
– Syndromes, e.g., neurofibromatosis
– MPNSTs and metastases
– Non-tumors, e.g., ganglion cysts, perineuriomas
• Entrapment neuropathies
• Pain
• Reconstruction
• Functional
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Clinical Neurosciences CenterDepartment of Neurosurgery
PERIPHERAL NERVE TERRITORY• Peripheral nerve tumors
– Benign
– Syndromes, e.g., neurofibromatosis
– MPNSTs and metastases
– Non-tumors, e.g., ganglion cysts, perineuriomas
• Entrapment neuropathies
• Pain
• Reconstruction
• Functional
Cutaneous schwannoma, 1/23/14
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Clinical Neurosciences CenterDepartment of Neurosurgery
PERIPHERAL NERVE TERRITORY• Peripheral nerve tumors
– Benign
– Syndromes, e.g., neurofibromatosis
– MPNSTs and metastases
– Non-tumors, e.g., ganglion cysts, perineuriomas
• Entrapment neuropathies
• Pain
• Reconstruction
• Functional
Plexiform schwannoma of lateral cord, 4/15/14
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Clinical Neurosciences CenterDepartment of Neurosurgery
PERIPHERAL NERVE TERRITORY• Peripheral nerve tumors
– Benign
– Syndromes, e.g., neurofibromatosis
– MPNSTs and metastases
– Non-tumors, e.g., ganglion cysts, perineuriomas
• Entrapment neuropathies
• Pain
• Reconstruction
• Functional
Malignant peripheral nerve sheath tumor of medial cord, 10/11/13
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Clinical Neurosciences CenterDepartment of Neurosurgery
PERIPHERAL NERVE TERRITORY• Peripheral nerve tumors
– Benign
– Syndromes, e.g., neurofibromatosis
– MPNSTs and metastases
– Non-tumors, e.g., ganglion cysts, perineuriomas
• Entrapment neuropathies
• Pain
• Reconstruction
• Functional
Intraneural ganglion cyst, 7/16/12
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Clinical Neurosciences CenterDepartment of Neurosurgery
PERIPHERAL NERVE TERRITORY
• Peripheral nerve tumors
• Entrapment neuropathies
– Simple: carpal, cubital
– Complex: revision, thoracic outlet syndrome
• Pain
• Reconstruction
• Functional
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Clinical Neurosciences CenterDepartment of Neurosurgery
PERIPHERAL NERVE TERRITORY
• Peripheral nerve tumors
• Entrapment neuropathies
– Simple: carpal, cubital
– Complex: revision, thoracic outlet syndrome
• Pain
• Reconstruction
• Functional
Cervical rib resection, 11/14/13
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Clinical Neurosciences CenterDepartment of Neurosurgery
PERIPHERAL NERVE TERRITORY
• Peripheral nerve tumors
• Entrapment neuropathies
• Pain
– Stimulation
– Neurectomies, e.g., triple neurectomy
• Reconstruction
• Functional
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Clinical Neurosciences CenterDepartment of Neurosurgery
PERIPHERAL NERVE TERRITORY
• Peripheral nerve tumors
• Entrapment neuropathies
• Pain
– Stimulation
– Neurectomies, e.g., triple neurectomy
• Reconstruction
• Functional
Robotic triple neurectomy 2/13/13
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Clinical Neurosciences CenterDepartment of Neurosurgery
PERIPHERAL NERVE TERRITORY• Peripheral nerve tumors
• Entrapment neuropathies
• Pain
• Reconstruction
– Brachial plexus injuries
– Traumatic/iatrogenic nerve injuries,
including facial nerve
– Spinal cord injuries
• Functional
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Clinical Neurosciences CenterDepartment of Neurosurgery
PERIPHERAL NERVE TERRITORY• Peripheral nerve tumors
• Entrapment neuropathies
• Pain
• Reconstruction
– Brachial plexus injuries
– Traumatic/iatrogenic nerve injuries,
including facial nerve
– Spinal cord injuries
• Functional
Multiple nerve transfers for brachial plexus injury, 6/3/13
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Clinical Neurosciences CenterDepartment of Neurosurgery
PERIPHERAL NERVE TERRITORY
• Pain
• Peripheral nerve tumors
• Entrapment neuropathies
• Reconstruction
• Functional
– Spasticity
– Dystonias
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Clinical Neurosciences CenterDepartment of Neurosurgery
PERIPHERAL NERVE TERRITORY
• Pain
• Peripheral nerve tumors
• Entrapment neuropathies
• Reconstruction
• Functional
– Spasticity
– Dystonias
Sitthinamsuwan et al., Stereotact Funct Neurosurg 2013
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Clinical Neurosciences CenterDepartment of Neurosurgery
PERIPHERAL NERVE TERRITORY
• Pain
• Peripheral nerve tumors
• Entrapment neuropathies
• Reconstruction
• Functional
– Spasticity
– Dystonias
Anderson et al., JNS 2008
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Clinical Neurosciences CenterDepartment of Neurosurgery
DISCUSSION TODAY
• Nerve injury reconstruction
• Spinal cord injury reconstruction
• Spasticity reduction
• Robotic prostheses for amputees
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Clinical Neurosciences CenterDepartment of Neurosurgery
NERVE INJURY
RECONSTRUCTION
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Clinical Neurosciences CenterDepartment of Neurosurgery
BRACHIAL PLEXUS RECONSTRUCTION• Primary plexus exploration and anatomical grafting
for extraforaminal nerve ruptures
• Distal nerve transfers for late presentation and use
of extraplexal donors for avulsions, e.g.,
– Oberlin and double-fascicular transfers
– Leechavengvong triceps branch to axillary nerve
– Spinal accessory nerve to suprascapular nerve
Guiffre et al., JHS 2010
Thoracodorsal and triceps to axillary,
ulnar and median to musculocutaneous
transfers 5/23/13
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Clinical Neurosciences CenterDepartment of Neurosurgery
NERVE GRAFTING
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Clinical Neurosciences CenterDepartment of Neurosurgery
NERVE TRANSFER
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Clinical Neurosciences CenterDepartment of Neurosurgery
EVEN SENSORY RESTORATION
Dorsal Ulnar Cutaneous
Lateral
Antebrachial
Cutaneous
From Brown, J. M, Mackinnon, S. “Nerve transfers in the forearm and hand.” Hand Clinics 24
(2008): 319–334.
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Clinical Neurosciences CenterDepartment of Neurosurgery
• Use of free-functioning muscle
transfers when appropriate
• Consideration of tendon transfer
options and selective joint fusions for
optimal results
Guiffre et al., JHS 2010
• Complex obstetrical brachial
plexus reconstruction,
including hemi-contralateral
C7 transfers
Hemi-contralateral C7 for OBPP 10/31/12
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Clinical Neurosciences CenterDepartment of Neurosurgery
FREE-FUNCTIONING MUSCLE TRANSFER
Gracilis free-functioning muscle transfer for brachial plexus injury, 12/8/14
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Clinical Neurosciences CenterDepartment of Neurosurgery
FREE-FUNCTIONING MUSCLE TRANSFER
Intercostal
nerves
Ribs
Pectoralis
Gracilis
graft
Gracilis free-functioning muscle transfer for brachial plexus injury, 12/8/14
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Clinical Neurosciences CenterDepartment of Neurosurgery
NERVE INJURY, TRAUMATIC OR IATROGENIC
• Common injuries
– Spinal accessory nerve injury on posterior
cervical triangle exploration
– Common peroneal grafting for knee dislocation
– Sciatic nerve palsy after total hip arthroplasty
• As well as nerve biopsy
– Sural, as outpatient
– Anywhere else, e.g.,
sciatic, superficial radial,
great auricular, etc.
Spinal accessory nerve iatrogenic injury, s/p failed exploration by
another neurosurgeon, grafted 11/26/12
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Clinical Neurosciences CenterDepartment of Neurosurgery
Internal neurolysis of
common peroneal nerve
Common peroneal
nerve (encased in
scar)
Tibial nerve
Transferred one of the 2 lateral gastroc branches to
the deep branch of the common peroneal nerve
Lateral head of
gastroc
Two branches to
lateral gastroc
Medial gastroc
branches
Tibial nerve to
post tib, foot,
etc.
Lateral gastroc branch transfer to deep peroneal fascicles, 12/23/14
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Clinical Neurosciences CenterDepartment of Neurosurgery
FACIAL REANIMATION• Immediate nerve transfer options for distal
nerve injuries and intracranial injury– Masseter branch of trigeminal nerve
– Cross-facial with or without side-to-end hypoglossal baby-sitter
– Hemihypoglossal
– Spinal accessory nerve
– Deep temporal branch of trigeminal nerve
• Free-functioning muscle transfers for late presentation or failed conservative management
Klebuc, PRS 2011
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Clinical Neurosciences CenterDepartment of Neurosurgery
NERVE INJURY
• Early referral is paramount
– Avulsion / nerve transection: immediate
surgery
– Stretch: surgery within 3-6 months
• All patients with neurological loss, even
brachial neuritis, may be a candidate for
reconstruction
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Clinical Neurosciences CenterDepartment of Neurosurgery
SPINAL CORD INJURY
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Clinical Neurosciences CenterDepartment of Neurosurgery
NERVE TRANSFERS FOR SPINAL
CORD INJURY
• Grasp• Brachialis branch to anterior interosseous nerve
• Brachialis branch to extensor carpi radialis longus
• ECRL branch to flexor policis longus
• Release• Supinator branch to posterior interosseous nerve
• Elbow extension • Posterior axillary branch to triceps
• Teres minor branch to triceps
• Bladder function
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Clinical Neurosciences CenterDepartment of Neurosurgery
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Clinical Neurosciences CenterDepartment of Neurosurgery
SUPINATOR to PIN
Radial Sensory
ECRB
PIN
Supinator
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Clinical Neurosciences CenterDepartment of Neurosurgery
AXILLARY TO TRICEPS
Triceps branch
Axillary nerve
Axillary nerveRadial nerve and
triceps branches
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Clinical Neurosciences CenterDepartment of Neurosurgery
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Clinical Neurosciences CenterDepartment of Neurosurgery
SPINAL CORD INJURY
• Referral during acute phase is beneficial
for patient mindset
• Extensive counselling and retraining is
key to mastery of new functions
• Nerve transfers for restoration of the
injured segment should be done prior to 6
months
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Clinical Neurosciences CenterDepartment of Neurosurgery
SURGICAL OPTIONS FOR
SPASTICITY
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Clinical Neurosciences CenterDepartment of Neurosurgery
ESSENTIAL RUBRIC
• Peripheral nerve / muscle
Focal spasticity
• Lumbar dorsal rhizotomies
Spastic diplegia
• Continuous intrathecal baclofen (iTB) infusion
Generalized spasticity
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Clinical Neurosciences CenterDepartment of Neurosurgery
TREATMENT OPTIONS
After failure of conservative / medications
• Peripheral neurotomies / neurectomies
• Tendon lengthening / muscle transfer
• Chemodenervation
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Clinical Neurosciences CenterDepartment of Neurosurgery
SURGICAL NEUROTOMY
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Clinical Neurosciences CenterDepartment of Neurosurgery
THE LOWER LIMB
• Obturator neurotomySpasticity of the adductor muscles
• Hamstring neurotomySpasticity of knee flexion
• Tibial neurotomySpastic foot & equinovarus
• Anterior tibial neurotomyEHL spasticity
• Femoral neurotomy Spasticity of the quadriceps
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Clinical Neurosciences CenterDepartment of Neurosurgery
THE UPPER LIMB
• Pectoralis major and teres major neurotomies
Spasticity of shoulder internal rotators
• Musculocutaneous neurotomy
Spasticity of elbow flexion
• Median and ulnar neurotomies
Spasticity of the pronators and flexors of the wrist and finger
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Clinical Neurosciences CenterDepartment of Neurosurgery
Radial neurotomies for triceps spasticity due to incomplete spinal cord injury, 3/27/13
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Clinical Neurosciences CenterDepartment of Neurosurgery
Radial neurotomies for triceps spasticity due to incomplete spinal cord injury, 3/27/13
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Clinical Neurosciences CenterDepartment of Neurosurgery
Radial neurotomies for triceps spasticity due to incomplete spinal cord injury, 3/27/13
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Clinical Neurosciences CenterDepartment of Neurosurgery
RESULTS
• Better positioning
• Reduced risk for contractures
• Greater mobility
• Increased use
• Broader independence
• Lower medication side effects
Sitthinamsuwan et al., Stereotact Funct Neurosurg 2013
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Clinical Neurosciences CenterDepartment of Neurosurgery
PHYSIOLOGIC RATIONALE
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Clinical Neurosciences CenterDepartment of Neurosurgery
REDUCE AFFERENT PATHOLOGY
• Varying on nerve & muscle type, ~25% to
~50% of a motor branch is efferent
• Desire to reduce information from afferent
type I and II fibers from muscle spindles
that mediate stretch reflexes
Gottschall J, et al. Anatomy and embryology 160:285-300, 1980
The goal is not to create palsy
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Clinical Neurosciences CenterDepartment of Neurosurgery
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Clinical Neurosciences CenterDepartment of Neurosurgery
DENERVATION AND REINNERVATION
• New motor endplates appear, and the size of motor units increases in proportion to the degree of denervation1
– On average, motor units increase by about five times their original size
• Reinnervation of the muscle spindles is generally non-functional
– Absence of long-term recovery of H-reflex
1: Dengler et al. Neurosci Lett 97:118-122, 1989
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Clinical Neurosciences CenterDepartment of Neurosurgery
EXTENT OF SECTION
• Scant scientific basis – individual
variability
• Most surgeons advocate 50% to 80%
(usually 75%) of branches to a particular
muscle1
• Maximal reinnervation – 8 months (H-
reflex)
1: Sindou et al. Childs Nerv Syst 23:957-970, 2007
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Clinical Neurosciences CenterDepartment of Neurosurgery
CERVICAL DYSTONIA
• Selective denervation and myomectomy for cervical dystonia
• Multidimensional care with EMG-guided Botox injections
Anderson et al., JNS 2008
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Clinical Neurosciences CenterDepartment of Neurosurgery
AMPUTEE
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Clinical Neurosciences CenterDepartment of Neurosurgery
MORE TO COME
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Clinical Neurosciences CenterDepartment of Neurosurgery
Thank you
Mark A. Mahan, MD
Office 801-585-7917
Cell 602-400-9697
Scheduling RN for provider
referrals 801-581-5200