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Building U.S.-IsraelLif S i P t hiLife Sciences Partnerships

Illinois ScienceThe BIRD Model Illinois Science&

Technology Park

Chicago

March 15, 2012

Dr. Eitan YudilevichExecutive DirectorBIRD F d i

11

BIRD Foundation

BIRD Foundation

Joint fund, established in 1977 as a joint initiative

BIRD = Binational Industrial Research and Development

, jbetween the US and Israeli governments

Mission FundingTo stimulate, promote and support joint (non-defense)

industrial R&D of mutual

Income from interest earned on $110 million endowment grant and from repayments

g

industrial R&D of mutual benefit to Israel and the

United States

grant and from repayments from successful BIRD

projects

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BIRD’s Approach in a Nutshell BIRD helps in finding strategic partners (“matchmaking”)

BIRD ff diti l t f j i t d l t

pp

BIRD offers conditional grants for joint development on a risk sharing basis (private sector cost-share)

BIRD funds up to 50% of each company’s R&D expensesBIRD funds up to 50% of each company s R&D expenses associated with the joint project

BIRD claims repayments as royalties only if commercial revenues are generated from the project (repayments: up to 150% of the original conditional grant, CPI adjusted)

As an example of mutual benefit: U S company benefitsAs an example of mutual benefit: U.S. company benefits from access to innovation and IP; Israeli company benefits from complementary required capabilities and market access (other combinations are possible e gaccess (other combinations are possible, e.g., complementary technologies)

March 201233

BIRD – Performance Summaryy

$295M granted

845 projectsp japproved

$94M repaymentsfrom projects

~$8B i l~$8B in sales generated directly and indirectly by BIRD sponsored activities

March 201244

The BIRD Model

March 201255

Repayments Schedule(Based on Revenue)(Based on Revenue)

Years from % of the grant Project

Completionto be repaid

Maximum repayment obligation: 150%

1 100%

Repayment rate: 5% of2 113%

3 125%

Repayment rate: 5% of Sales

Semiannual repayments4 138%

5 & Be ond 150%

Semiannual repayments, indexed to CPI-U

5 & Beyond 150%

March 20126

Submitting Process (two cycles per year)** For the exact dates of the upcoming cycle see www birdf com

Executive Summaries March SeptemberCycle I Cycle II

For the exact dates of the upcoming cycle see www.birdf.com

Executive Summaries

Final Proposal

Proposal Evaluation

March September

April October

Proposal EvaluationEvaluators appointed by NIST

& the Chief Scientist’s Office

DecisionsAt the Board of Governors’Meeting

June December

Company to Company Agreement

Cooperation and Project Funding AgreementMarch 20127

Once Project is Awarded…

Company to Company Agreementp y p y g

Financial Due Diligence

Cooperation and Project Funding AgreementCooperation and Project Funding Agreement

Project performance

Every 6 months:Financial &

End of project: Auditperformance a c a &

Milestone Reports Sales report

8 March 2012

BIRD Approved Projects by Industry2006 20112006- 2011

Communications15%Cleantech

18%

Others

HLS6%

4%

Life Sciences29%

Software

Healthcare IT4%

Electronics15%

Software9%

March 201299 Total # of Projects = 144, including “BIRD Energy” (13 projects)

Examples of projects approved in 2011Israeli

CompanyUS

CompanyProject Area

ARTART Healthcare

Hydrofera Anti pulmonary aspiration seal Medical Devices

BioMarCareTechnologies

AriadneDiagnostic test for metastatic colorectal cancer

Life SciencesTechnologies colorectal cancer

Healarium The Mayo ClinicApplication for self monitoring of cardiovascular risk

Healthcare IT

Semantic Medical Simulations –SMS

Sitel/MedStar Health

Semantic medical simulation platform Healthcare IT

AGM Tonson EndoStimMiniaturization of an implantablemedical device for GERD

Medical Devices

MedCPU Cleveland ClinicCare Pathway Decision Support

Healthcare IT

March 20121010

MedCPU Cleveland ClinicProject

Healthcare IT

Semantipedia Daylight CIS Semantic Web for Life Sciences Healthcare IT

Examples of BIRD Awardees Israeli CompaniesIsraeli Companies

MITAM

E t hExotechBio Solutions

March 201211

Examples of BIRD Awardees Israeli Companies - continuedIsraeli Companies continued

March 20121212

Examples of BIRD AwardeesIsraeli Companies - continuedIsraeli Companies continued

March 201213


Bet Shemesh Engines

March 201214


March 201215

BIRD AwardeesExamples of US CompaniesExamples of US Companies

March 20121616

BIRD AwardeesExamples of US Companies - continuedExamples of US Companies - continued

March 20121717


March 201218


March 201219


March 2012

3 Decades of collaboration

More about BIRD -Specific Project Examples

2121

Medical Devices

CByond specialized in designing video-scopes for

Project title:

Fox Electronic Video Cameradesigning video scopes for medical applications.

ACMI (American Cystoscope Makers, Inc.; Now: Gyrus ACMI, an Olympus company), is a leader in the development and production of the world’s finest endoscopy

Joint development product:Flexible endoscope with integrated miniature video camera and LED as a li ht

March 201222

world s finest endoscopy instrumentation for the medical industry.

light source.

Slide Approved by Companies or Information is Public Domain22

Medical Instrumentation

Argo Medical invented the external wearable skeleton enabling the

Project title: ReWalk – Clinical Trials at MossRehab (Philadelphia)

walking of paraplegic patients.

Allied Orthotics & ProstheticsJoint development product: ReWalk is a motorized exoskeleton suit that enablesAllied Orthotics & Prosthetics

business is the design, custom-manufacturing, fitting, training of a complete range of orthotic and

th ti d t f di bl d

motorized exoskeleton suit that enables patients with lower limb disabilities, including complete paralysis, to independently engage in ambulatory activities, including standing, walking and in some cases climbing stairs.

prosthetic products for disabled people.

g g

Slide Approved by Companies or Information is Public Domain23 June 2010

g5ZY1a8http://www.youtube.com/watch?v=IaiO

Life Sciences - Pharma

Bio-Technology General Ltd. had extensive expertise in production and

f f

Project title: Development of PEG-Uricase for Treatment of Intractable Gout and Related Conditions

purification of recombinant proteins for parenteral use (acquired by Savient Pharmaceuticals Inc.)

Mountain ViewJoint development product: Development of

ff ti th f ti t ithMountain View Pharmaceuticals, Inc.experts in protein chemistry and the synthesis of PEG

effective therapy for patients with severe and presently untreatable gout. The drug is called Krystexxa, marketed by Savient

March 201224

derivatives.y

Pharmaceuticals

BIRD Project in the PressBIRD Project in the Press

April 201125

Healthcare/Orthodontics

Project title: 3D Imaging for

Cadent develops and sells proprietary 3D-based services to

Project title: 3D Imaging for Orthodontics (Presently marketed by Cadent only)

dental officesNote: Cadent established a significant U.S. operation as well (NJ)

3M U it k d i f tJoint development product:

(NJ)

3M Unitek designs, manufactures and sells of orthodontic appliances, and it is the world’s largest supplier of these products (Acquired by 3M in

Computer-guided bracket placement system that calculates optimal bracket placement positions, saving time, reducing errors and increasing treatment

Slide Approved by Companies or Information is Public Domain26 March 2012

p ( q y1987) efficiency

Software/Healthcare

P j t titl

Aliroo Ltd. is an international developer of innovative enterprise I f ti d I t t S it

Project title:Advance Secure eMail System ("ASES”)

Information and Internet Security solutions.

Eastman Kodak: Kodak's Health

Joint Development product: Secure E-Mail Service for healthcare services, which can encrypt e-mail messages and theirEastman Kodak: Kodak's Health

Imaging Group is a world leader in developing, manufacturing and marketing intelligent imaging products from analog to digital (in 2007 became Carestream Health)

encrypt e-mail messages and their attachments so that patient information and images can be sent securely over the Internet to physicians, patients and other healthcare providers.

27

digital (in 2007 became Carestream Health)

Slide Approved by Companies or Information is Public Domain

Food Technology

Fresh-Point is a private company specializes in the area of smart

Project title: Novel Time Temperature Indicators.

packaging, such as novel organic crystal-based time-temperature indicator

Ciba Specialty Chemicals Corp is aFreshness check at a glance – OnVu™ time-t t i di t h l t d hill h iCiba Specialty Chemicals Corp. is a

leading global company dedicated to producing high-value effects for its customers’ products. Joint development product: novel printable &

chargeable time temperature indicator

temperature indicators show accumulated chill-chain history of perishables

March 201228

chargeable time temperature indicator


Software/Healthcare

P j t titl

Joint development product:

MediViz Systems- Medical IT software company developing

Project title:Operating Room Decision Support Center (ORDSC) Joint development product:Highly reliable operational data collectionsolution for the perioperative environment, supplying decision support tools

decision support solutions within high acuity care environments

problem identification,

Cedars Sinai Medical Center

p ,assignment, tracking andresolution assurance.

Cedars-Sinai Medical Center-serves the greater LA area; highly ranked nationally; promotes and markets use of advanced technology

March 201229

to deliver the highest quality of medical care


Molecular Imaging

Project title: Real time visualization of

Aposense Ltd. is a clinical stage molecular imaging and drug development

Project title: Real-time visualization of apoptosis within solid tumors

molecular imaging and drug development company, with a pipeline of products based on its patented platform technology for targeting apoptosis (programmed cell death) in vivo

Joint development product: Synthesis of radio-isotope labeled apoptosis marker and subsequent clinical studies

IBA Molecular North America is a leading global provider of PET radiopharmaceuticals

subsequent clinical studies. The usage of the labeled marker will enable real time visualization of efficacy of anti tumor treatment and will provide improved time and spatial resolution.

Slide Approved by Companies or Information is Public Domain March 201230

Bionic Eye

Project title: : Nano Retina

Rainbow Medical: is a medical devices innovation house, already responsible for

Project title: : Nano Retina

innovation house, already responsible for the successful launching of design and implementation of numerous medical devices.

Joint development product: A nanotechnology approach for sight

t ti b d A tifi i l R tiZyvex Labs exploits its predecessor company Zyvex Corporation’s technology for Micro-Electro-Mechanical-Systems (MEMS) microfabrication and 3D

restoration based on an Artificial Retina which interfaces electrodes with living retinal cells (neurons)


microassembly.

March 201231


Kamada specializes in the manufacture of therapeutic

Project title: Development of the API Manufacturing Process

pharmaceuticals from human plasma, using chromatographic separation techniques.

GLASSIATM

The American Red Cross (ARC) Joint Development:The project is to develop scale-up

GLASSIATM

( )collects ~6 million units of whole blood per year. One million liters of human plasma are derived to be manufactured into a variety of therapeutic plasma

The project is to develop, scale-up, manufacture and market API (Alpha-1-Proteinase Inhibitor), which is a protein synthesized in the liver and secreted into serum


into a variety of therapeutic plasma protein pharmaceuticals.

serum.

March 2012


Project title: Novel therapeutics for

Atox Bio, Ltd. develops therapeutics for treatment of severe sepsis, septic

Project title: Novel therapeutics for severe sepsis and septic shock

p pshock and toxic shock.

Fast-Track Drugs and Biologics, LLC. g g ,is a contract research organization (CRO)

providing strategic planning, clinical trial and regulatory support services to the pharmaceutical and biotech industries for

Joint development product: pre-clinical and phase I studies in collaboration with the University of Maryland.

4/3/201233

pharmaceutical and biotech industries for the development and licensure of vaccines and therapeutics for human diseases.

Neurotechnology Seminar in Washington D CWashington, D.C.

Save the Date!

”Israel Neuroscience & Neurotechnology Collaborations‐Accelerating U.S.“ Israel Neuroscience & Neurotechnology CollaborationsAccelerating U.S.

Wednesday, September 12, 2012 - 8:30 am - 5:00 pmNational Academy of Sciences - 500 5th St. NW Washington, D.C.

The human brain is the most complex object of study in the history of science Brain research is affecting the life of all of us at any time.

The US-Israel conference will bring together researchers and companies from both countries to discuss their collaboration in investigating and understandingboth countries to discuss their collaboration in investigating and understanding

the function of the brain and showcase novel technologies that lead to new breakthroughs in the diagnosis and treatment of neurological disorders.

Thank You!

www.birdf.com

35 March 201235

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