skeletal disorders. objectives: copyright 2003 by mosby, inc. all rights reserved
TRANSCRIPT
Copyright 2003 by Mosby, Inc. All rights reserved.
Assessment Techniques
• Bone x-rays• Bone marrow aspiration • Bone marrow biopsy • Radionuclide bone scan • Computed axial tomography (CAT) • Magnetic resonance imaging (MRI) • Bone densitometry
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Bone Scan• Radioactive tracer is given intravenously
• Amount of uptake is related to amount of blood flow to the bone
• “Hot spots” are areas of increased metabolic activity that may indicate cancer, abnormal healing or growth
• “Cold spots” indicate decreased metabolism of decalcified bone, fracture or bone infection
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Hormonal Abnormalities/Imbalances
• Oversecretion of hGH during childhood produces giantism
• Undersecretion of hGH or thyroid hormone during childhood produces short stature
• Both men or women that lack estrogen receptors on cells grow taller than normal– estrogen is responsible for closure of growth
plate
Copyright 2003 by Mosby, Inc. All rights reserved.
Disorders of the Skeletal System • Ankylosing spondylitis
– A hereditary chronic spinal disease
• Arthritis– A group of disorders evidenced by inflammation
of a joint, pain and stiffness during movement
• Avulsion fracture– Occurs when a ligament or tendon pulls off part
of a bone during an injury
• Bursitis – Inflammation of the sac around a joint that is
caused by trauma or irritation
Copyright 2003 by Mosby, Inc. All rights reserved.
Disorders of the Skeletal System (continued)
• Caries – Also called cavities, it is the major cause of tooth
loss
• Carpal tunnel syndrome– A disorder caused by pressure on the median
nerve of the wrist due to repetitive use or trauma
• Degenerative joint disease– Also called osteoarthritis, usually associated with
aging; it is the most common form of arthritis
Copyright 2003 by Mosby, Inc. All rights reserved.
Disorders of the Skeletal System (continued)
• Dislocation – When bones move out of their proper
location, usually in the shoulder or hip
• Fracture – A broken bone caused by trauma
• Gout – A painful swelling of a joint that results from
the buildup of uric acid crystals, most commonly in the great toe
Copyright 2003 by Mosby, Inc. All rights reserved.
Disorders of the Skeletal System (continued)
• Herniated disk– A ruptured or “slipped” disk between
vertebrae
• Kyphosis – Also called “hunchback” or “humpback,” is
an abnormal curvature of the thoracic part of the spine
• Lordosis – Also called “swayback,” is an abnormal
curvature of the lumbar spine
Copyright 2003 by Mosby, Inc. All rights reserved.
Disorders of the Skeletal System (continued)
• Meningomyelocele– Also called spina bifida, is a congenital
condition of the spinal column
• Osteoma– A bone tumor
• Osteomalacia – Also called rickets in children, is a softening
of the bones caused by vitamin D and calcium deficiency
Copyright 2003 by Mosby, Inc. All rights reserved.
Disorders of the Skeletal System (continued)
• Osteomyelitis – A bacterial infection of the bone
• Osteoporosis – A weakening of the bones
• Paget’s disease– Also called osteitis deformans, is due to
excessive destruction of bone cells
Copyright 2003 by Mosby, Inc. All rights reserved.
Disorders of the Skeletal System (continued)
• Periodontitis – An inflammation of the tissues that keep
teeth in place
• Rheumatoid arthritis – Pain and stiffness in the joints caused by
thickening of the synovial membrane
• Rickets – A painless deformity at the epiphysis of the
bones caused by insufficient vitamin D
Copyright 2003 by Mosby, Inc. All rights reserved.
Disorders of the Skeletal System (continued)
• Scoliosis– An abnormal lateral spinal curvature
• Subluxation – A partial dislocation of a joint, such as in the
neck in a “whiplash” injury
• Talipes– A congenital deformity involving the foot
and ankle
Osteoporosis- cont.
• Osteoporosis– Group of diseases in which bone reabsorption
outpaces bone deposit– Spongy bone of the spine is most vulnerable– Occurs most often in postmenopausal women– Bones become so fragile that sneezing or
stepping off a curb can cause fractures
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Osteoporosis-cont.• Decreased bone mass resulting in porous bones
• Those at risk– white, thin menopausal, smoking, drinking female with
family history – athletes who are not menstruating due to decreased body
fat & decreased estrogen levels– people allergic to milk or with eating disorders whose
intake of calcium is too low
• Prevention or decrease in severity– adequate diet, weight-bearing exercise, & estrogen
replacement therapy (for menopausal women)– behavior when young may be most important factor
Osteoporosis: Treatment
• Calcium and vitamin D supplements
• Increased weight-bearing exercise
• Hormone (estrogen) replacement therapy (HRT) slows bone loss
• Natural progesterone cream prompts new bone growth
• Statins increase bone mineral density
Rickets cont.
• Rickets
• Risk Factors/Causes:– Bones of children are inadequately mineralized
causing softened, weakened bones– Bowed legs and deformities of the pelvis, skull,
and rib cage are common– Caused by insufficient calcium in the diet, or by
vitamin D deficiency
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Rickets cont.
• Rickets Treatment:– Dietary changes– Exercise– Reversible if caught early
• Osteomalacia• new adult bone produced during remodeling fails to
ossify
• hip fractures are common
Osteomalacia cont.
• Osteomalacia– Bones are inadequately mineralized causing
softened, weakened bones– Main symptom is pain when weight is put on
the affected bone– Caused by insufficient calcium in the diet, or by
vitamin D deficiency
Paget’s Disease cont.
• Characterized by excessive bone formation and breakdown
• Pagetic bone with an excessively high ratio of woven to compact bone is formed
• Pagetic bone, along with reduced mineralization, causes spotty weakening of bone
• Osteoclast activity wanes, but osteoblast activity continues to work
Paget’s Disease cont.
• Usually localized in the spine, pelvis, femur, and skull
• Unknown cause (possibly viral)
• Treatment includes the drugs Didronate and Fosamax
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HOMEOSTATIC IMBALANCES of Joints
• Lyme disease is a bacterial disease which is transmitted by deer ticks. Symptoms include joint stiffness, fevers, chills, headache, and stiff neck.
• Ankylosing spondylitis affects joints between the vertebrae and between the sacrum and hip bone. Its cause is unknown.
• Ankle Sprains and Fractures: The ankle is the most frequently injured major joint. Sprains are the most common injury to the ankle; they are treated with RICE. A fracture of the distal leg that involves both the medial and lateral malleoli is called a Pott’s fracture.
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Rheumatism and Arthritis cont.• Osteoarthritis is a degenerative joint disease
commonly known as “wear-and-tear” arthritis. It is characterized by deterioration of articular cartilage and bone spur formation. It is noninflammatory and primarily affects weight-bearing joints.
• Gouty arthritis is a condition in which sodium urate crystals are deposited in soft tissues of joints, causing inflammation, swelling, and pain. If not treated, bones at affected joints will eventually fuse, rendering the joints immobile.
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Rheumatoid Arthritis
• Autoimmune disorder• Cartilage attacked• Inflammation, swelling
& pain • Final step is fusion of
joint
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Osteoarthritis• Degenerative joint disease
– aging, wear & tear
• Noninflammatory---no swelling– only cartilage is affected not synovial membrane
• Deterioration of cartilage produces bone spurs– restrict movement
• Pain upon awakening--disappears with movement
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Gouty Arthritis
• Urate crystals build up in joints---pain– waste product of DNA & RNA metabolism– builds up in blood– deposited in cartilage causing inflammation &
swelling
• Bones fuse
• Middle-aged men with abnormal gene
Copyright 2003 by Mosby, Inc. All rights reserved.
Issues and Innovations • Progress in dental care
– Corrective measures including bonding, bleaching, and implants
• Bone substitutes and repairs– Bone replacing material including organoapatites
and coral– Surgical implants for cranial and joint injuries– Bone regeneration
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Arthroscopy & Arthroplasty
• Arthroscopy = examination of joint– instrument size of pencil– remove torn knee cartilages & repair ligaments– small incision only
• Arthroplasty = replacement of joints– total hip replaces acetabulum & head of femur– plastic socket & metal head– knee replacement common
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Innovations for cartilage replacement
• In cartilage transplantation chondrocytes are removed from the patient, grown in culture, and then placed in the damaged joint.
• Eroded cartilage may be replaced with synthetic materials
• Researchers are also examining the use of stem cells to replace cartilage.