“Signaling in cell death survival, proliferation and degeneration ”

Conference location:São Paulo Brazil

June­10­13, 2011

Organizers:

Soraya Smaili, Sergio Lavandero, Richard Lockshin, Roya Khosravi­Far and Zahra

Zakeri

June 10 th 2:00pm – 6:00pm:

“ Signaling in cell death survival, proliferation and degeneration ”

Conference location: São Paulo Brazil

June­10­13, 2011

Organizers:

Soraya Smaili, Sergio Lavandero, Richard Lockshin, Roya Khosravi­Far and Zahra Zakeri

June 10 th 2:00pm – 6:00pm:

Welcome Introduction and awards

Chair: Zahra Zakeri, Dept. of Biology, Queens College of CUNY, USA

2:00­2:15pm Introduction and welcome

Zahra Zakeri: Queens College, U.S.A.

2:15­2:30pm Presenting Award to Dr. Guido Kroemer

Richard A. Lockshin: St. Johns University, U.S.A

2:30­3:30pm Cancer cell death; killing the immortal

Guido Kroemer. Institut Gustave Roussy, France

3:30­4:00pm Coffee Break

Pathways to cell death and cell survival

Chair: Marie­Lise Gougeon, Institut Pasteur, France

4:00­4:30pm Integration of glucose metabolism and apoptosis by the BCL­2 family protein BAD

Nika Danial, Dept. of Pathology, Harvard University, USA

4:30­5:00pm New functions of the BCL­2 protein family on ER physiology

Claudio Hetz, Inst. of Biomedical Sciences, Univ. of Chile, Chile

5:00­5:30pm Physiological mechanisms mediated by the prion protein in the control of cell death and survival

Rafael Linden, Instituto de Biofisica da UFRJ, Brazil

5:30­5:45pm Increased ER­mitochondrial coupling stimulates mitochondrial metabolism during early stages of ER stress.

Roberto Bravo, Univ. Chile, Santiago, Chile

5:45­6:00pm Analysis of apoptosis regulatory genes controlled by histone deacetylase inhibitors in chronic lymphocytic leukemia cells,

Joan Gil, University of Barcelona­IDIBELL, Spain

7:00pm Social hour Dinner

June 11 th 9:00am – 7:30pm

Regulation of cell death in cancer I

Chair: Marianne J Cronje, Univ. Johannesburg, South Africa

9:00­9:30am Desirable off­target effects of anticancer agents

Laurence Zitvogel, INSERM and Institut Gustave Roussy, Villejuif, France

9:30­10:00am Sensitivity and resistance in preclinical cancer model

Klaus­Michel Debatin, Children’s Cancer Center, Ulm, Germany

10:00­10:30am Novel cell death regulatory pathways in cancer

Gustavo Amarante Mendes , Universidade de São Paulo, São Paulo, Brazil

10:30­11:00am Coffee Break

Regulation of cell death in cancer II

Chair: Katharina D'Herde, Dept. Human Anatomy and Embryology, Fac. Medicine, Univ. Gent, Belgium

11:00­11:30am Cell death pathways to cancer

Roya Khosravi­Far, Dept. of Pathology, Harvard U. Med. School, USA

11:30­12:00am A dual role for galectin­3 in cell death within specialized tissue

microenvironment

Roger Chammas – University of São Paulo, Brazil

12:00­12:15pm Enhancement of TRAIL­induced apoptosis by Homoharringtonine in human

colon cancer cells

Jarmila Stremenova­­ Charles University in Prague, Prague, Czech Republic

12:15­12:30pm MicroRNA­10b is down­regulated in head and neck cancer and could

impact cancer development through kfl4 signaling

Flavia Maziero Andreghetto, Albert Einstein Research and Education Institute, São Paulo, Brazil

12:30­2:00pm Lunch

Regulation of cell death in cancer III

Chair: Andrew Quest, University of Chile, Chile

2:00­2:30pm Exploiting cell death signaling pathways to overcome cancer resistance

Simone Fulda. Institute for Experimental Cancer Research in Pediatrics, Goethe­University Frankfurt

2:30­3:00pm Redox regulation of cell fate in cancer cells

Shazib Pervaiz, National University Health System, Singapore

3:00­3:30pm The p53 family between development, cell death and cancer

Gerry Melino, Univ. di Roma ‘Tor Vergata’, Italy and MRC, Univ. of Leicester, UK – Not confirmed by

registration

3:30­4:00pm Coffee

Regulation of Death in Neurodegeneration and Neuroprotection I

Chair: Maria de Fatima Leite, Federal University of Minas Gerais, Brazil

4:00­4:30pm The prion protein as a survival target in Alzheimer’s disease

Vilma Martins – Cancer Hospital, São Paulo, Brazil

4:30­5:00pm S100B releasing as a signal of astrocyte activation to survival or death

Carlos Alberto S. Gonçalves – Federal University of Minas Gerais Brazil

5:00–5:15am Study of calcium signalling in a rat model of sporadic Alzheimer's Disease

Leticia Rodrigues, Federal University of São Paulo

5:15–5:30am p53 protein directly regulates the mitochondrial PTP pore during oxidative stress­induced necrosis and ischemic stroke

Ute Moll – Dept. of Pathology, Stony Brook University, Stony Brook NY

5:30­7:30pm Poster Session

8:00pm Dinner

June 12 th 9:00am – 7:30pm

Regulation of Death Chair: Sergio Lavandero, Univ. of Chile School of Medicine, Santiago,Chile

9:00­9:30am Role of TRPM4 in cell death

Andres Stutzin, Univ. of Chile, Santiago, Chile

9:30­10:00am Prostate epithelial cell apoptosis: new approaches to an old model

Hernandes Carvalho – University of Campinas, São Paulo, Brazil

10:00­10:15 A natural cytotoxic peptide from the venom of South American rattlesnake targets tumor cells in vivo, triggers cell death by calcium­dependent pathway and shows significant efficacy in melanoma tumor in vivo model

Mirian Hayashi, Universidade Federal de São Paulo (UNIFESP)

10:15­10:30am Apoptotic and non­apoptotic roles of caspases in embryonic tooth­bone complex formation

Eva Matalová, Czech Academy of Sciences Prague, Czech Republic

10:30­11:00am Coffee Break

Regulation of Death Chair: Nader Maghsoudi, Neuroscience Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran

11:00­11:30am The survivin/Cox2 connection to tumor suppression by caveolin 1

Andrew Quest, University of Chile, Chile

11:30­12:00pm Intracellular pathogens and cell death

Marisa Isabel Colombo, Universidad Nacional de Cuyo ­ Mendoza ­ Argentina

12:00­12:15pm Combining cell death and immune stimulation using p19Arf and IFNb in a B16F10 tumor vaccine model

Ruan Medrano, InCor HCFM­USP, São Paulo, Brazil

12:15­12:30pm Overcoming tumor and virus strategies to keep cells alive: translation of

mouse models into a human disease

Julian Pardo, Univ. of Zaragoza, Spain

12:30­2:00pm Lunch

Young scientist Mentoring Workshop: How the young scientists in the field can survive, network

and excel.

Moderator: Zahra Zakeri, Dept. of Biology, Queens College of CUNY, USA

2:15­ 2:45pm What are the obstacles holding back scientists?

Soraya Smaili, Departamento de Farmacologia, Universidade Federal de São Paulo (UNIFESP/EPM), São Paulo, SP, Brazil.

2:45­ 3:45pm Panel discussion:

Panelists : Roya Khosravi­Far; Marie­Lise Gougeon; Guido Kroemer ; Simone Fulda; Eileen White; Marianne J Cronje; Soraya Smaili; Marisa Isabel Colombo, Gerry Melino, Simone Fulda

Regulation of Death Chair: Simone Fulda , Institute for Experimental Cancer Research in Pediatrics, Goethe­University Frankfurt

4:00­4:30pm Double stranded DNA virus tools to cope with cell stress and death

Covadonga Alonso: Dpt. Biotecnologia, Universidad Autónoma de Madrid, Spain

4:30­5:00pm TAM Receptors in Immune Modulation and Clearance of Apoptotic Cells

Raymond Birge: UMDNJ­New Jersey Medical School, Newark, NJ USA

5:00–5:15am Flavivirus NS4A­induced autophagy protects cells against death and

enhances virus replication

Emmanuel Datan, Queens College of CUNY, New York, NY USA

5:15–5:30am Dengue virus infection upregulates cell death markers in human

monocytes and caspase inhibitor modulates virus load

Amanda Torrentes­Carvalho, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro

5:30­7:30pm Poster Session

8:00pm Dinner

June 13 th 9:00am – 2:00pm

Targeting autophagic cell death pathways

Chair: Mauro Piacentini, National Institute for Infectious Diseases IRCCS L. Spallanzani, and Univ. de

Roma “Tor Vergata”, Rome, Italy

9:00­9:30am The role of bec­1 in C. elegans development and aging

Alicia Melendez Queens College, U.S.A.

9:30­10:00am Role of Ambra1 in autophagy regulation: far beyond Beclin 1 interaction

Gian Maria Fimia, National Institute for Infectious Diseases IRCCS L. Spallanzani, Rome, Italy

10:00–10:15am The role pf MKP­1 in autophagy and apoptosis during

ischaemia/reperfusion injury in the heart

Anna­Mart Engelbrecht­ Stellenbosch University, Stellenbosch, South Africa

10:15–10:30am The dual PI3K/mTOR inhibitor NVP­BEZ235 and chloroquine synergize to

trigger apoptosis through lysosomal membrane permeabilisation in neuroblastoma cells

Christian Seitz, Goethe­University Frankfurt am Main,Germany

10:30­11:00am Coffee

Pathways to cell death and cell survival II

Chair: Soraya Smaili, Departamento de Farmacologia, Universidade Federal de São Paulo

(UNIFESP/EPM), São Paulo, SP, Brazil.

11:00­11:30am DOR: a new regulator of autophagy

Antonio Zorzano, Institute for Research in Biomedicine (IRB Barcelona), Spain

11:30­12:00pm Wrap up

Richard Lockshin, St. John’s Univ., Jamaica NY, USA

12:00­2:00pm Lunch and End of Meeting