PROTEIN REPAIRS ESOPHAGEAL

DNA DAMAGE AND THIRTEEN NEW LOCI LINKED

TO AGE OF MENOPAUSE ONSET

LAURA BECERRA RUIZMedicine Student

2012

FOLDING

FOLDING

INTRODUCTION

The DNA containing the genetic instructions used in the development and functioning of all known living organisms. DNA has two processes

• DNA replication is a biological process that occurs in all living organisms and copies their DNA.

• DNA repair refers to a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode. its genome.

 

PROTEIN REPAIRS ESOPHAGEAL DNA DAMAGE

 

PROTEIN REPAIRS ESOPHAGEAL DNA DAMAGE

Esophageal cancer is usually begins in the cells that line the inside of the esophagus. Esophageal cancer can occur anywhere along the esophagus, but it occurs most often in the lower portion of the esophagus. More men than women get esophageal cancer.

Taken from: http://blog.amesred.com/

Dysphagia and odynophagia are the most common symptoms of esophageal cancer. Dysphagia is the first symptom in most patients. Odynophagia may also be present. Fluids and soft foods are usually tolerated, while hard or bulky substances (such as bread or meat) cause much more difficulty.

Taken from: http://yobrietjimenez-conociendolalectura.blogspot.com/2011/04/los-alimentos.html, http://www.mybwmc.org/library/34/100181,

 

PROTEIN REPAIRS ESOPHAGEAL DNA DAMAGE

p73 is a protein related to the p53 tumor protein, it has been considered a tumor suppressor, also this gen It is involved in cell cycle regulation, and induction of apoptosis.

The p73 gene encodes a protein with a significant sequence homology and a functional similarity with the tumor suppressor p53. The over-expression of p73 in cultured cells promotes a growth arrest and/or apoptosis similarly to p53.

Taken from: http://en.wikipedia.org/wiki/File:Protein_TP73_PDB_1cok.png

 

PROTEIN REPAIRS ESOPHAGEAL DNA DAMAGE

OBSERVATIONI think that the development of this techniques (the use of the gen p73) is a good advance in medicine and a new opportunityto heal the cancer, because this disease have one of the higher and must alarming mortality rates around the world, killing daily millions of people, so if we as doctors can make a better life to the people who suffer of this disease that should be a number one objective to all the society and one of the reason to keep growing in knowledge and in new techniques that help us get there.

Taken from: http://youngatheartfrenchsforest.files.wordpress.com/2011/05/0511-0803-2716-1630_lady_p-i-_looking_for_clues_clipart_image.jpg

 THIRTEEN NEW LOCI LINKED TO AGE OF MENOPAUSE ONSET

THIRTEEN NEW LOCI LINKED TO AGE OF MENOPAUSE ONSET• The menopause is formally

medically defined as the time of the last menstrual period (or menstrual flow of any amount, however small).

• The transition from reproductive to non-reproductive is the result of a reduction in female hormonal production by the ovaries.

• The menopause transition, and postmenopause itself, is a natural life change, not a disease state or a disorder.

Taken from: http://www.healblog.net/health-news/conditions-for-menopause/

THIRTEEN NEW LOCI LINKED TO AGE OF MENOPAUSE ONSET

The new loci contained candidate genes involved in DNA repair and immune function. Pathway analyses indicated that biological processes associated with these loci were exodeoxyribonuclease, NFκB signaling, and mitochondrial dysfunction.

Taken from:http://www.desertangelbook.com/health-info/menopause-hormone-therapy-increase-the-risk-of-kidney-stones.html

THIRTEEN NEW LOCI LINKED TO AGE OF MENOPAUSE ONSET

Menopause is based on the natural or surgical cessation of estradiol and progesterone production by the ovaries, which are a part of the body's endocrine system of hormone production, in this case the hormones which make reproduction possible and influence sexual behavior.

Common symptoms are: Hot Flashes

Night Sweats Irregular Periods

Loss of LibidoVaginal Dryness

Taken from:http://www.heavenandearthessentials.com/index.php?main_page=product_info&cPath=70_86&products_id=1097

OBSERVATION

After reading this new, I recognize the importance of the menopause phenomenon like a biological change in the woman that can open the door to a body´s health decrease, accelerating the aging of the senses. In that way, a closer study of loci focused in age of menopause, will bring welfare for the woman all over the world, because this loci it´s related to multiple diseases that are very common and significant in the females population and their family.

Taken from: http://truebornrecords.com/wp-content/uploads/2011/10/looking-glass-72.jpg

MEDICAL UTILITY

MEDICAL UTILITY

The study of DAN repair mechanisms is very promising to reduce the incidence of cancer and in the menopause process.

Taken from:http://filamfriends4ever.com/jeeps-dieta-menopausia-precoz/

MEDICAL UTILITY

The use of p73 protein regulates the expression of multiple DNA repair genes.

p73 may play a tumor suppressor role in the esophagus and could represent a target for therapies to combat esophageal cancer.

Taken from: http://www.facebook.com/note.php?note_id=199495180073009&comments

MEDICAL UTILITY

The loci with application in the menopause, contained candidate genes involved in DNA repair and immune function.

The repair search reduce the effects of menopause and the connections between this hormonal change and cardiovascular disease, breast cancer, osteoporosis Taken from:

http://www.aorana.com/info/menopausia-2/tratamientos-para-la-menopausia/

BIBLIOGRAPHY

L Stolk, J Perry, A Murra,J Murabito,J Visser ,K Lunetta. Thirteen New Loci Linked to Age of Menopause Onset. DOCTORSLOUNGE [INTERNET MAGAZINE] January 26, 2012 [ Consult date 01 February, 2012] Available on: http://www.doctorslounge.com/index.php/news/pb/26275.

Marino M. Protein repairs esophageal DNA damage. Vanderbilt University Medical Center [INTERNET MAGAZINE] 25 Jan 2012 [Consult date 01 february, 2012]. Available on: http://news.vanderbilt.edu/2012/01/protein-repairs-esophageal-dna-damage/.

Taken from: http://firefox-goodies-blog.blogspot.com/2011/08/thanks-for-donating.html