diapositivas plegable
TRANSCRIPT
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CANCER: SOME CELLS DON'T KNOW WHEN TO STOP AND DISCOVERY OF NEW CLASS OF DAMAGE-PRONE DNA REGIONS COULD LEAD TO BETTER CANCER TREATMENTSLaura Barrientos
Third semester
Medical student
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INTRODUCTION
Central dogma of genetic information:
DNA replication:
ProteinsRNADNA
DNA is replicated from
its same moldRNA is replicated from a
DNA`s mold
Proteins are synthesized from RNAm`s mold
In this process a
DNA molecule
synthesize a new DNA molecule
This process
occurs in the phase S of the cell
cycle
This is important because if there is a mistake, occurs a mutation
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CANCER: SOME CELLS DON'T KNOW WHEN TO STOP
Cancer arises from DNA damage in
fragile sites in the genome, like
repetitive sequences.
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CANCER: SOME CELLS DON'T KNOW WHEN TO STOP
B cells lymphocytes are the cells that have more
risk to have DNA damage.
Also by the AID
The rason is because they divide rapidly.
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CANCER: SOME CELLS DON'T KNOW WHEN TO STOP
Early replicating frgile sites (ERFSs)
are AID-independient
ERFSs are associeted with the DNA breaks.
ERFSs are the principal cause of
alteration in B cells lymphoma
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CANCER: SOME CELLS DON'T KNOW WHEN TO STOP
The replication of DNA damage helps to adpat and survive to the cells when there is a metastasis.
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PEERSONAL COMMENT
This new is very importante becuase now there is a better knowledge about the mechanism of the cancer, so the scientists can improve treatment and this will improve the quality of life.
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DISCOVERY OF NEW CLASS OF DAMAGE-PRONE DNA REGIONS COULD LEAD TO BETTER CANCER TREATMENTS
Some cells can resist these drugs.
Chemoterapy drug stop DNA replication in the cancer cells
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DISCOVERY OF NEW CLASS OF DAMAGE-PRONE DNA REGIONS COULD LEAD TO BETTER CANCER TREATMENTS
There are checkpoints mutants that create damaged DNA, this can cause cancer
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DISCOVERY OF NEW CLASS OF DAMAGE-PRONE DNA REGIONS COULD LEAD TO BETTER CANCER TREATMENTS
Normally cells can recognize when they loss nucleotides, but checkpoints mutants dont recognize this signal.
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DISCOVERY OF NEW CLASS OF DAMAGE-PRONE DNA REGIONS COULD LEAD TO BETTER CANCER TREATMENTS
Some cells continue with the replication of damaged
DNA.
There is a collapse
point where strands break.
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PERSONAL COMMENTWith this investigation scientists know what are the failures in the treatment, and other cause of cancer. So now they can create other methods to trear this disease.
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MEDICAL BENEFIT
With these knowledges the cancer´s treatment can improve, and this probably will save many lifes.
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MEDICAL BENEFIT
In cancer and helthy cells we can find problems in the replication, so now scientists must to create methods to control and supervise these problems.
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MEDICAL BENEFIT
Scientists can create a method to identify which cells have problems in the replication, and the way to stop them.
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MEDICAL BENEFIT
To understand the consequences of the chemotherapy, and know why this can not traet cancer by 100%, but this can improve it.
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BIBLIOGRAPHY
Martínez S, Lina Maria. Biología Molecular. 5 ed Medellín: UPB. Facultad Medicina.
Cancer: Some Cells Don't Know When to Stop. Science Daily. November 19, 2012
Discovery of New Class of Damage-Prone DNA Regions Could Lead to Better Cancer Treatments. Science Daily. January 24
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GRACIAS