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ISSUE 22 September 2011

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We

enable the reduction of statin consumption. CardiaBeat is ideal for incorporation into dairy products, due to its healthy market image and the natural presence of fat, which can be substituted or augmented by the ingredient. Its use in food applications has just been launched in Europe, which has thus far been the focus of

Enzymotec's investments.

NutraNews™ September 2011

ISSUE 22

Ingredient of the Month The company behind Recent ingredients Regulatory Updates Top 20 September Industry News Letter of the Month – Super Seeds Contact Published and Powered by: NUTRAFILES® -a division of

Canadean Ltd

Ingredient of the Month

This month’s high scorer within the Nutrafiles benchmarking system on market penetration is: BENEO’s inulin. Orafti

® inulin is extracted from chicory roots

and is composed of glucose and fructose chains. Inulin has good solubility and an excellent taste profile. Orafti

® inulin can be used to replace fat and sugar and to increase the dietary

fibre content of food and drink products. It is especially suited for use in dairy, bakery and cereals, confectionery, beverages and baby food products. Many food producers also use inulin in their products to enhance the fibre content, improve the texture, increase calcium absorption from a diet and for its prebiotic effect and the influence it has on digestive health. The ingredient has a wide spread market penetration due to its diversity in

many types of applications, which has been further exploited by various

qualities designed for particular application areas. Recent development is

Orafti®L58 (liquid and organic), produced from organic sugar. Orafti

®L58

Organic offers customers outstanding technological and nutritional properties,

as a prebiotic fibre to promote good digestive health, but can also be used to

replace sugar in a multitude of applications.

Orafti® inulin, a range of products

Orafti®ST-Gel Instant-gel forming Orafti

®HPX HP for high temperature

processes

Orafti®GR Granulated Orafti

®LGI Low sugar inulin

Orafti®HP High-performance Oraft

®HSI High soluble inulin

Orafti®Synergy1 oligofructose-enriched inulin for calcium absorption

claims

The ingredient is found in about all food & drink applications: beverages, confectionery, bakery, cereals, dairy, baby food, supplements and many more.

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The Company Behind

ENEO-Orafti Head Quartered in Tienen, Belgium, operates in more than 75 countries and has production units in Oreye (Belgium), and Pemuco (Chile).

BENEO-Orafti is part of BENEO; a division of the Südzucker Group, this division employs almost 900 people and has production units in Belgium, Chile, Germany and Italy. Operating entities BENEO-Orafti

Production companies

Tienen, Belgium (HQ) Oreye, Belgium

Singapore, Singapore Pemuco, Chile

Barcelona, España

Saõ Paulo, Brazil

Morris Plains, New Jersey, USA

BENEO’s product portfolio consists of functional ingredients with nutritional and technical advantages, derived from chicory roots, beet sugar, rice and wheat. BENEO is the ideal partner to help improve the health, taste, texture and nutritional value of a product. Through a unique chain of expertise, including the BENEO-Institute, BENEO actively supports industry partners in the development of more balanced and healthy food products. BENEO-Institute: The Institute aims to advise customers and partners, reaching from ingredient approvals, physiological effects and nutritional composition to communication and labelling. As such, customers can benefit from the latest research in nutritional science and advice on claims and other regulatory affairs topics that range from prebiotics over functional sugar to rice derivates. The key nutritional topics that will form the basis of the BENEO-Institute’s work include weight management, digestive health, bone health, physical and mental performance, the effects of a low glycaemic diet in the context of healthy eating and disease prevention as well as dental health.

BENEO-Technology Center: The Center brings together BENEO’s long-standing food application and technical expertise to enhance and encourage product innovation. As such it complements BENEO’s chain of expertise providing customers with specialist advice to tackle technical questions in product development and formulation.

BENEO’s core competencies

Ingredients from nature

Health, Nutritional and Technological benefits

Product development & application technology

Market & consumer research

Concept development

Nutritional science & regulatory support through BENEO-Institute

More Information: www.beneo.com

B

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Recent Ingredients

Ageing Glycosann SOL OxyPhyte Ultra blend

Cognitive & Nerves

Rhosavin 100 MEGANOL EPA&DHA

General Nutrition ClearSweet corn syrups Cleardex corn syrups Isosugar IsoClear high fructose corn syrup Satin Sweet 65% high maltose corn syrup

Growth MagGran MC

Gut Health Orafti Oligo-fructose

Heart & Circulatory

Stelessterol Tensio Control Pomega3 Aqua 10 Omelife Smooth FUXIONS

OxyPhyte Blueberry Extract MagGran DC Megapex

Immune OxyPhyte grape concentrate OxyPhyte Grape Skin 10% Resveratrol Graviola Licorice Series Lalmin Se

Performance& Sport

Hyvital Whey CMA 500 Hyvital Wheat Glutamine PA G4 Syrup Clintose maltodextrin

Reproductive Testoterone Advantage

Skeletal & Joint PrimaFlex Glycollagen Glycopure Glucosamine Sulphate 2KCL Chondronat Co-Joint Chondroitin K2Vital MagGranCC

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Skin Oral OxyPhyte Grape Seed Extract OxyPhyte White Tea Extract AquaCacteen

Weight Management & Metabolism

Volactive UltraWhey 90 D-xylose CTR Fructofin C Fructopure Krystar Orafti Inulin OxyPhyte Yerba Mate Polyphenols OxyPhyte Green Tea Extract SteviaCane Chrominex3+ Green Coffee Bean NEOSORB- Sorbitol Powder NEOSORB- Sorbitol solution ChitoClear

Basic Profiles In future the Nutrafiles Ingredients database will be extended with general food grade ingredients for that purpose a category named General Nutrients are being implemented as part of the system.

September Regulatory Updates

Vitamins D

DSM Nutritional Products Europe AG, has recently got an EFSA expert opinion for a health Claim related to Article 14 of Regulation (EC) No 1924/2006. The EFSA Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health claim related to vitamin D and risk of falling.

The Panel considers that the following wording reflects the scientific evidence: “Vitamin D may reduce the risk of falling. Falling is a risk factor for bone fractures”. The Panel considers that, in order to obtain the claimed effect, 800 I.U. (20 μg) of vitamin D from all sources should be consumed daily. The target population is men and women 60 years of age and older

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Market

Biology Action

Health Area

Regulatory

Novelty

IPR

Tripeptide IPP VPP

Valio Ltd, Finland, had submitted a proposed health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 to the EFSA Panel on Dietetic Products, Nutrition and Allergies. The panel was asked asked to deliver an opinion on the scientific substantiation of a health claim related to isoleucyl-prolyl-proline (IPP) and valyl-prolyl-proline (VPP) and maintenance of normal blood pressure (BP). The Panel concluded that a cause and effect relationship has not been established between the consumption of IPP and VPP and maintenance of normal blood pressure.

In weighing the evidence, the Panel took into account that 13 of the human intervention studies provided, four of which were adequately powered to detect small between-group differences in SBP, did not observe an effect of IPP and VPP on SBP or DBP; that the interpretation of the results from seven out of the eight studies which reported an effect of IPP and VPP on office SBP was hampered by major methodological limitations; that the animal studies did not provide additional information on the effect of IPP and VPP on BP in humans; and that there is no convincing evidence for a mechanism by which IPP and VPP could exert the claimed effect at the proposed dose.

Top 20 in September

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Industry News

Nisshin OilliO to acquire Industrial Quimica

The Nisshin OilliO Group, Ltd., a Japanese manufacturer and seller of edible oils, has entered into a stock purchase agreement to acquire 85% stake in Industrial Quimica Lasem, S.A., a manufacturer of chemicals for cosmetic industry,

from Josep Betriu Pi, Josep Marti Pellise and Mercapital, S.L. for a consideration of EUR26 million ($36.71). Both Industrial Quimica and Mercapital are based in Spain.

Mercapital operates as a private equity firm.

Nisshin OilliO also holds a right to acquire remaining 15% stake in Quimica Lasem. Edme to form joint venture with Cerex

Edme Limited, a UK-based producer of ingredients for the baking, cereal and food industries, has agreed to form a joint venture with CereX BV, a Netherlands-based producer and seller of natural cereal extracts, to distribute malt extracts in the UK and in Europe.

Edme will combine the production, packaging and distribution capabilities with CereX. It has also invested GBP0.35 million ($0.54 million) in a new packaging facility

Cargill to form joint venture with Grupo USJ

Cargill, Incorporated, a producer of food, agricultural, financial and industrial products and services based in the US, has entered into a joint venture with Grupo USJ, a Brazilian producer of sugar, ethanol and bioelectricity.

SJC Bioenergia is a new 50-50 joint venture company formed which combines industrial assets of Grupo USJ and other mills.

In addition to sugar and ethanol, SJC Bioenergia will also generate electricity from sugarcane baggage.

Kuantan Flour Mills announces rights issue of 24.78 million shares

Kuantan Flour Mills Bhd. (KFM), a Malaysian producer of wheat flour, pre-mix and trading products, has agreed to issue up to 24.78 million shares of MYR0.50 ($0.17) each at an issue price of

MYR0.51 ($0.178) per shares payable in full upon acceptance.

The shares have been paid on the basis of one rights share for every two existing ordinary shares of MYR0.50 ($0.17) each held in KFM together with up to 37,168,725 new free detachable warrants on the basis of three warrants for every two rights shares subscribed.

AFFIN Investment Bank Bhd. is acting as a merchant banker to KFM on the transaction.

WILD Flavors to acquire assets of A.M. Todd Company

WILD Flavors (Schweiz) AG, a Swiss manufacturer of natural ingredients for the food and beverage industry, has reached an agreement to acquire certain assets of A. M. Todd Company, a US-based provider of mint flavours and ingredients.

The transaction is expected to complete by October 31, 2011.

Biothera partners with United States Pharmacopeial Convention (USP)

The United States Pharmacopeial Convention (USP) has entered into a collaboration agreement to develop a monograph for beta glucan from baker’s yeast with Biothera, a developer of health ingredients for functional foods and beverages, nutritional supplements, cosmetics and animal nutrition products. Both companies involved in the transaction are based in the US.

USP is a scientific non-profit organization that sets standards for the quality, purity, identity, and strength of medicines, food ingredients, and dietary supplements manufactured, distributed and consumed worldwide.

Biothera contributed the reference standard and two methods for identifying and quantifying the beta 1,3/1,6 branched glucan polymer derived from the cell walls of baker’s yeast as well as additional methods to assure the purity of the material.

Viocare acquires DSM Personalized Nutrition from Royal DSM

Viocare, Inc., a provider of wellness and nutrition-based systems, has acquired DSM Personalized Nutrition LLC, a provider of whole-health wellness services, from Royal DSM N.V., a Netherlands-based life sciences and material sciences company.

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Viocare and DSM Personalized Nutrition are based in the US.

Pursuant to the transaction, DSM will remain involved in the business as a minority shareholder in Viocare through DSM Venturing.

Kerry agrees to acquire SuCrest

Kerry Group plc, a UK-based provider of food ingredients and flavours for the food and beverage industries, has entered into an agreement to acquire Sucrest GmbH, a German provider of sweet ingredients to the bakery, ice-cream, confectionery, cereal and snack sectors.

The transaction is expected to be completed by December 31, 2011.

Olam International plans to acquire Vallabhdas Kanji

Olam International Limited, a Singapore-based company engaged in supply chain management of agricultural products and food ingredients, is planning to acquire Vallabhdas Kanji Limited (VKL), a processor of spice and spice ingredients, from The J. V. Mariwala Group, a company engaged in the business of food ingredients, spices and spice extraction. Both VKL a

nd J.V. Mariawala are based in India.

Global Sweeteners to acquire Changchun Jincheng Corn

Global Sweeteners Holdings Limited has entered into a sale and purchase agreement to acquire the entire issued share capital of Changchun Jincheng Corn Development Co., Ltd., a Chinese wholly-owned subsidiary of Global Bio-chem Technology Group Company Limited, a manufacturer and seller of corn refined products, for a purchase consideration of HKD510 million ($65.44 million). Both Global Sweeteners and Global Bio-chem are based in Cayman Islands.lobal Sweeteners is a manufacturer of corn based refined and sweetener products, while Changchun Jincheng is a corn refinery plant with a processing capacity of 600,000 metric tonnes per annum.

The consideration will be satisfied upon completion of the acquisition by Global Sweeteners allotting and issuing to Global Bio-chem 377,778,000 new shares at an issue price of HK$1.35 ($0.17) per consideration share.

Upon the issue and allotment of the consideration shares, Global Bio-Chem’s shareholding in Global Sweeteners will increase from 52.23% to 64%.

Letter of the Month

Super seeds for heart and performance Karin Elisa Nielsen, Division Director Nutrafiles, Canadean Ltd

As an ingredient, cocoa beans are found in numerous food and beverage products and support the most important demands from modern consumers; - indulgence, health support and performance booster. What more do we need? The seeds from the tropical tree Theobroma cacao L, were initially traded by the Mayans (200 BC until 1500 AD) to the Aztecs, who used them in drinks and various dishes. Today cocoa is consumed mainly as a confectionary or drink flavouring. When properly sweetened, cocoa’s flavour pleases most consumers. However, the sugar is a concern; recently it was announced that a naturally sweetened, tooth friendly chocolate containing stevia would be launched in UK, early in 2012. Also, Barry Callebaut’s recent consumer survey revealed

that 1 in 3 Europeans wants chocolates with health benefits and 4 in 10 want a reduced sugar content. On the other hand, perhaps consumers are getting used to the bitter taste, as they recognise dark chocolate to be healthier, and the consumption grows faster today representing up to 40% market

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share in major markets. Ancient cocoa drinks were different - bitter strong drinks that probably were more like coffees and teas. These bitter notes come mostly from the various polyphenols present in cocoa. Modern biotechnology has identified that processing, as well as crops, may influence the content of bio actives. More than 10% of flavanols by weight are found in the cocoa mass. Flavanols are also the main subject of interest for the cocoa health and nutritional science. The highest flavanol content is in the dark chocolate. Clinical studies confirm that dark chocolate in comparison with milk or white chocolate exerts the healthy heart benefits. Clinical data from chocolate studies has been various, but unfortunately very biased due to the fact that blind studies are difficult – the testers are too accustomed to chocolate and can effortlessly identify chocolate to a placebo. The healthy heart benefits are partly attributed to the potent antioxidant capacity of cocoa flavanols as studies have shown that high consumption populations produce more nitric oxide than low consumption groups. The flavonoids, or more specifically the flavanol, epicathecin, has been demonstrated to increase blood capillary widening (vasodilatation) and this is regulated specifically by nitric oxide. Healthy heart benefits are further substantiated by studies on blood pressure in normal healthy subjects. By consumption of dark chocolate, systolic blood pressure was significantly reduced, and still was by 5% for eight weeks after trials ended. In a meta-analysis the blood pressures were reduced 4.7 mm (systolic) and 2.8 mm (diastolic) as compared to non-cocoa consuming controls. Another health benefit related to heart health is the cholesterol and blood triglyceride lowering effect of dark chocolate, which recently has been scrutinised in a meta-analysis of science from 10 studies verifying that dark chocolate indeed, had a significant reduction of LDL cholesterol and total cholesterol. Good news is that the active dose seems to be lower than 500 mg a day, and some supplementation studies favour approximately 300 mg – allowing a beneficial effect on consuming 100g of quality dark chocolate per day – or using ingredients as Acticoa and Cocanox offering increased bioavailability and standardised high levels of flavanols. Cocoa also contains anadamines, caffeine, theobromine, and phenyletylamine, all compounds

related to cognitive functions and exerting increasing energy and alertness. However, any potent effect may not be expected from normal consumption, whereas studies show that encapsulated or inhaled cocoa may give other results. Interestingly, caffeine has just been granted an EFSA health claim on alertness– could cocoa be next? It definitely has the reputation of being a mood food. Additionally many essential nutrients are found in rich measures in cocoa, as essential minerals: potassium, calcium, magnesium, iron and zinc.

Main Sources:

INRA – Polyphenol-explorer

Shroeter et al. Proc Natl Acd Sci 2006

Taubert et al. Arch Int Med 2007

Tokede et al. Eur J J Nutr 2011

Contact Information

Canadean Ltd www.nutrafiles.com

Tel.: +44 (0)1256 394 200 info@nutrafiles.com Nutrafiles@anadean.com

Disclaimer: Reasonable care has been taken in preparing this document and the information provided herein is believed to be accurate. However, this information is not reviewed by any authority as EFSA or FDA.

0

50

100

150

200

250

300

DarkChocolate

MilkChocolate

Chocolatemilk

mg/

10

0g

or

ml

Flavanols Flavonols

Hydroxycinnamic acids Stilbenes

Figure 1. Cocoa Polyphenol contents