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NutraNews June / July 2011

ISSUE 20

Nutrafiles – a Division of Canadean Ltd Ingredient of the Month The Company Behind Recent Ingredients Regulatory Updates Top 20 June Letter of the Month Contact Published and Powered by: NUTRAFILES® -a division of Canadean Ltd

NUTRAFILES® a Division of Canadean

Dear Client and Reader, As per July 1, 2011 Nutrafiles Ltd has become a division of Canadean Limited, and part of the Progressive Digital Media Group. We are looking forward to collaborating with you in the new settings of Basingstoke and London. We have planned many interesting market intelligence products for supporting your future business in relation to product innovation, market trends and ingredient uses. We are delighted to discuss how these can help you optimize your business. Formerly Managing Director of Nutrafiles Ltd is now Director of Nutrafiles Division, Canadean, and will be working for future developments in collaboration with all the Canadean and PDM personnel. We wish you a nice summertime. Kind Regards, Karin Elisa Nielsen, The Nutrafiles Team Profile of Nutrafiles Division at Canadean Developing and providing client based and multi-client online analytical tools on food and beverage ingredient markets, analyse ingredient companies, health ingredient information and bench marking on IP and scientific levels. Part of Canadean, the leading global beverage research company.

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Ingredient of the Month CardiaBeat® /Omega Sterols™ from Enzymotec have received the Award of the Month June/July for its regulatory Score. CardiaBeat® “C” and “F” grades for functional foods are plant-sterol-based matrixes, capable of reducing “bad’ cholesterol, together with additional health benefits, plant sterols cannot provide. This is an ingredient that addresses the dual health challenges of unhealthy cholesterol and triglyceride levels in the blood. CardiaBeat strives to offer total lipid control for cardiovascular disease (CVD) patients or individuals at high risk of CVD such as those suffering from diabetes or obesity. Whereas other CVD solutions on the market often only address one aspect of CVD risk factors (LDL and HDL cholesterol, triglycerides, oxidative-stress), CardiaBeat, a unique combination of phytosterols and DHA and EPA, is capable of simultaneously lowering 'bad' cholesterol and triglyceride levels, while also improving the ratio between total cholesterol and 'good' cholesterol levels. This is achieved without the main weakness of phytosterols, which is reduction of fat soluble vitamin absorption (such as beta-carotene). The formula consumed at 2g per day delivers 1.6g of conjugated phytosterol-DHA and phytosterol-EPA (full RDA of phytosterol-esters) and up to 650mg of DHA and EPA. Thus, products containing CardiaBeat can claim both cholesterol and CVD-risk reduction. The ingredient acts through a different mechanism than lipid-lowering pharmaceuticals (statins). Thus when consumed in combination with

statins it might improve the lipid-lowering effect or enable the reduction of statin consumption. CardiaBeat is ideal for incorporation into dairy products, due to its healthy market image and the natural presence of fat, which can be substituted or augmented by the ingredient. Its use in food applications has just been launched in Europe, which has thus far been the focus of Enzymotec's investments. CardiaBeat® grade for dietary supplements is capable of reducing blood levels of “bad’ cholesterol, triglycerides and improving the ratio

between total to HDL “good” cholesterol. CardiaBeat's ability to reduce CVD risk factors in healthy human subjects was

clinically evaluated at McGill University in Canada, under the

supervision of Prof Peter Jones [Demonty, et al. AmJ Clin Nutr

Dec 2006;84(6):1534-1542]. In this study, the

ingredient's hypolipidaemic effects were compared to

supplementation with fish oil and phytosterol esters of sunflower oil.

All supplements were administered on top of an olive-oil based diet and

tested in a semi-randomised, single-blind, crossover intervention design.

Additionally CardiaBeat® has received gained GRAS status in the US and Novel Food in Europe.

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The Company Behind

Enzymotec is a dynamic biotechnology company and a leading global supplier of lipid-based products and solutions. The

company develop, manufacture and market innovative bio functional ingredients and final products based on sophisticated proprietary technologies. Enzymotec offers high quality lipid-based products as original solutions for body and mind. The company aims at employing state of the art processing tools, lipid technology expertise and the highest manufacturing standards. The research and development team are introducing new products clinically tested under the supervision of top scientists in leading medical centres. Enzymotec’s goal is to provide their customers with the safest, most effective and highest quality products. With 150 employees worldwide, the company is currently active in more than 40 countries. Enzymotec strategic partners are leading pharmaceutical companies and nutrition firms. The dietary supplement products can be found in leading health and drug stores worldwide. Enzymotec's headquarters, research and development centre and GMP-compliant manufacturing facility are located in Israel. Their USA office is located in New Jersey, and the company also have a joint venture with AAK in Sweden and a manufacturing facility for raw-materials in India. Enzymotec's products deliver innovative solutions in three business segments: Orthomolecular Medicine, Dietary Supplements and infant nutrition

markets. Company's main focus areas are solutions for improving cognitive functions, reducing CVD risk and balanced nutrition for babies and toddlers.

Ingredient Brands are

Sharp PS Sharp PS Silver Sharp PS Gold Sharp PS Green Sharp GPC Sharp GPC Active Krill Oil + Omega Choline

Further information, pls. contact

Enzymotec

Tel: + 972 74 717 7177

Fax: + 972 74 717 7001

Mrs. Orly Farkash

Marketing Department

info@enzymotec.com

E

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Recent Ingredients

Ageing Pido-Manganese®

Cognitive & Nerves

Posinol™

Dental & Oral BLIS K12 BLIS M18 CE90CPP

Gut Rosell-175

Heart PinVita™

Immune 5-loxin

Infections Cranbumycin®

Menopausal Lifenol

Metabolic Opextan® BioEcolians® Quinolean

Performance Pido-Magnesium®

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Skeletal & Joint

Chondroitin sulfate Pido-Calcium®

Skin Pido-Zinc® SootheSkin Q Vida®

Special Medical Needs

BioPURE-GMP™ Glycomacropeptide (GMP) GMP Enhanced WPI LACPRODAN® CGMP

Regulatory Updates

POSITIVE OPINIONS EFSA HEALTH CLAIM OPINIONS - ARTICLE 13, BATCH 5 Published: 30 June 2011

Foods/food constituents Health Area Positive EFSA Opinions

Fats Bioavailability Dietary intake of fats helps normal absorption of fat-soluble vitamins. Triacylglycerols and fatty acids facilitate the absorption of fat-soluble components (e.g. vitamins A, D, E and K, and carotenoids) by the formation of micelles in the small intestine. However, the evidence provided didn’t establish that inadequate intake of fats leading to impaired absorption of fat-soluble vitamins occurs in the general EU population. Link

Glycaemic carbohydrates Cognitive Health Glycaemic carbohydrates help maintain normal brain function if 130g consumed daily. Link

Oat and barley grain fibre

Gut Health Oat and barley grain fibre increases faecal bulk (in “high fibre” foods). Link

Rye fibre Gut Health The Panel concluded that a cause and effect relationship has been established between the consumption of rye fibre and changes in bowel function. The Panel considers that in order to bear the claim a food should be at least “high in fibre” as per Annex to Regulation (EC) No 1924/2006. Link

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Foods/food constituents Health Area Positive EFSA Opinions

Reduced lactose Gut Health Consumption of foods with reduced lactose content may help to decrease gastro-intestinal discomfort caused by lactose intake in lactose intolerant individuals. Link

Reduced dietary sodium Heart Health Reduction of dietary sodium intake helps maintain a normal blood pressure. Link

Chitosan Heart Health Chitosan can help maintain normal blood LDL-cholesterol concentrations if 3g consumed daily. Link

Beta-glucans from oats and barley

Metabolic Health The Panel concluded that a cause and effect relationship has been established between the consumption of beta-glucans from oats and barley and a reduction of post-prandial glycaemic responses. In order to obtain the claimed effect, 4 g of beta-glucans from oats or barley for each 30 g of available carbohydrate should be consumed per meal. Link

Very low calorie diets (VLCDs)

Metabolic Health The Panel concluded that a cause and effect relationship has been established between the consumption of a very low calorie diet and reduction in body weight. The Panel considered that in order to bear the claim, a diet should comply with the specifications and conditions of use laid down in CODEX STAN 203-1995. Link

Arabinoxylan produced from wheat endosperm

Metabolic Health Arabinoxylan produced from wheat endosperm can reduce post-prandial glycaemic responses if 8g of arabinoxylan-rich fibre produced from wheat endosperm (at least 60 % arabinoxylan by weight) per 100 g of available carbohydrates should be consumed. Link

Fructose Metabolic Health Consumption of fructose in place of sucrose or glucose in foods or beverages can help reduction of post-prandial glycaemic responses. In order to bear the claim, glucose or sucrose should be replaced by fructose in sugar sweetened foods or beverages. Link

Sodium Muscle & Skeletal Health

The Panel concluded that a cause and effect relationship has been established between the dietary intake of sodium and maintenance of normal muscle function. However, the evidence provided didn’t establish that inadequate intake of sodium leading to impaired muscle function occurs in the general EU population. Link

Carbohydrate-electrolyte solutions

Performance Carbohydrate-electrolyte solutions enhance water absorption during exercise and maintain endurance performance (when drink contains 80-350kcal/L from carbohydrates, at least 75% of the energy from high-GI carbohydrates and 20-50mmol/L sodium). Link

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Market

Biology Action

Health Area

Regulatory Status

Novelty

IPR

Foods/food constituents Health Area Positive EFSA Opinions Melatonin Performance The Panel concluded that a cause and effect relationship

has been established between the consumption of melatonin and reduction of sleep onset latency. The Panel considered that in order to obtain the claimed effect, 1 mg of melatonin should be consumed close to bedtime. Link

Top 20 in June

Letter of the Month

Berry Flavonoids – a nutritional powerhouse.

-Abdul Qudoos, Nutrafiles Consultant & founder @ healthyfoodmanagement.com The flavonoids presences in berries are among the most powerful medicinal foods known. Plus they resemble colour and taste good for both humans and animals. The richer in colour, the greater are its powers. For instance, black raspberries are more powerful than red raspberries. Also black currants have greater medicinal activity than, for instance, gooseberries. Even so, all berries have medicinal properties. Flavonoids exist in berries in rich amounts; they are exotic and diverse family of compounds known as the flavonoids, the colorant of fruit. The other names for this colorant include phytochemicals, polyphenols,

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phenols and bioflavonoids. In fact, these substances are essentially natural drugs – without the side effect as powerfully stated by Jean Carper in her book “The Food Pharmacy”. People who regularly eat berries usually have excellent bone density. These special functions of berry flavonoids have recently been documented. Researchers have discovered that extracts of berries, for instance, blackberries, directly influence the function of the cell membrane. Here, the extracts stimulate the mechanisms which coordinate the transportation of ions: calcium, sodium, phosphorus, chloride, and similar substances. This function seems to be universal, that is for all cells in the body. The effectiveness of the flavonoids and beneficial to human health has been shown encouraging results since ages mostly in Cardiovascular disease, Arterial disease, Diabetes, Macular degeneration, Pulmonary fibrosis, Cancer, Asbestosis, Capillary fragility diseases, Emphysema, Capillary mesh integrity, Peripheral edema, Trigeminal neuralgia and other neuralgias. Flavonoids Rich Berries are:

Cranberry: Contain powerful phytochemicals & phytonutrients that promote wellness and help to prevent age-related chronic diseases, cardiovascular diseases, certain stomach ulcers and even cancer. Over the past 30 years, scientists have confirmed the long heritage of the cranberry’s goodness, particularly as it related to urinary tract health – cleanses urinary tract, helps kill bacteria and fungi in the urinary tract and gut; strengthens kidneys but also intestinal wall; strengthens gums and destroys toxic oral bacteria.

Blackberry: Known to be Sedative & Pain Reliever. Cleanses digestive tract and blood; cleanses spleen; detoxifies colon; helps improve bone density. Also long term effects as Antibacterial, Anticancer, Anti-Diabetic, Anti-Diarrheal, Anti- dysenteric, Anti-Heartburn, Anti-hemorrhagic, Anti-Inflammatory, Antioxidant, Antipyretic, Astringent, Diuretic, and Tonic.

Blueberry: Known to be Sedative, Pain Reliever & Stimulant. Blueberry improves the function of the retina; improves skin tone; improves brain function and prevents brain cell degeneration; strengthens pancreas and improves blood sugar control; also cleanses urinary tract. An effective nutritious and medicinal supplement rich in antioxidant compounds, which battle cell and DNA damage associated to heart disease, diabetes, malignant disease, etc.

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Brindleberry/Indian Berry (Amla): Known to be Stimulant & Weight Loss. Also long term effects as Anticancer, anti-catarrhal, anti-helminthic, antioxidant, antiseptic, anti-ulcer, appetite suppressant, astringent, cardio tonic, demulcent, thermogenic. Blocks sugar conversion to fat, widely used as an appetite suppressant and effective agent against lipids, body fat & cholesterol. It can be used in Herbal appetite suppressant, Energy Drinks, Weight loss remedies, Liquid speed, etc.

Chokeberry (Aronia melanocarpa) has been traditionally used by Potawatomi Native Americans to cure colds. Among other substances, the berries of A. melanocarpa contain anthocyanins and procyanidins, possessing strong antioxidative potential, additionally the fruit has a high C-vitamin content. The active principle of Chokeberry contains a mixture of procyanidins, anthocyanins and phenolic acids – constitutes one of the most potent natural antioxidants. The anthocyanin cyanidin-3-galactoside has high antioxidant capacity, and it is speculated that inhibition of COX-2 inhibition is considered its main function. COX-2 enzyme is stimulated by injury or some form of attack on the body and controls inflammatory processes.

Goji Berry/Wolfberry: Known to be Aphrodisiac, Stimulant & Pain Reliever. Known widely as traditional Chinese longevity enhancer (anti-aging), research supported to be useful treatment for psoriasis, allergies, arthritis and Inflammatory conditions, blood builder, cancer prevention and management, cardiovascular health, diabetes (adult-onset, non-insulin-dependent), gastrointestinal disorders, hypertension (high blood pressure), immunity, infertility, liver protection, obesity, periodontal disease, sexual dysfunction, vision improvement and also helps athletic performance and provides energy. Goji berries are usually found dried; they are shrivelled red berries that look like red raisins. Method of use: as whole fruit – Berries & Juice. It can be used in Herbal appetite

suppressant, Energy Drinks, Weight loss remedies, Liquid speed, etc. Raspberry: Known to be Hypnotic, Depressant, Sedative, Stimulant & Pain Reliever. Method of use: as whole fruit – Berries & Juice, Wine, Syrup, etc. The ripe fruit is fragrant, sub acid and cooling: it allays heat and thirst, and is not liable to acetous fermentation in the stomach. Red raspberry improves the function of the female organs; balances breast tissue; cleanses the blood. Black raspberry cleanses colon and liver, cleanses blood and spleen, boosts bone marrow function; directly attacks and destroys cancer cells. It can be used in Herbal appetite suppressant, Energy Drinks, Weight loss remedies, Liquid speed, etc.

Blackcurrant: The fruit has extraordinarily high vitamin C content (302% of the Daily Value per 100 g) and a broad range of essential nutrients. A black currant strengthens joints and connective tissues; improves blood counts;

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rebuilds immune system; balances female sex glands; strengthens skin and smoothens skin. Balances the circulatory system and fights inflammation in the arteries. Black currants uses are dietary supplements, snacks, functional food products and as quick-frozen (IQF) produce for culinary production as jams & preserves. Besides being juiced and used in jellies, syrups, and cordials, blackcurrants are also used in cooking because their astringency creates flavour in many sauces, meat dishes, and desserts. Flavonoids rich fruits can be incorporated into your diet in many ways:

Add dried fruits to tossed salads, oatmeal, black and hand-pound rice preparation, mix-trail with some nuts and some healthy desserts.

Some flavonoids rich fruits can be substituted for raisins in quick breads and muffins. Blend flavonoids rich fruits to make healthy smoothies. Fresh or IQF flavonoids rich fruits can be used in homemade jams, fruit preparations, marmalades,

tarts, pies, cobblers, etc.

Some Ingredients with Procyanidins in Nutrafiles

Appjfnol, Arolia, BerryVin™, CoffeeBerry®, Cranberry 90MX, Cranberry Extract, Cranberry extract High PAC 36:1, Cranbumycin®, CranLife™, Crannose™, CranPure™, exGrape® TOTAL, Exocyan® Cran, EXOCYAN® FR. Grapurit™, Lingonberry Powder 100%, LingonMax™, Lingonol, Oligonol, Orocyan, PACran®, UTIrose, Vinanza® Skin Performance Plus

More Reading

Antimicrobial activity against select food-borne pathogens by phenolic antioxidants enriched in cranberry pomace by solid-state bioprocessing using the food grade fungus Rhizopus oligosporus. Vattem DA, Lin YT, Labbe RG, Shetty K. Process Biochem. 2004;39(12):1939-1946

Phenolics and anthocyanins in berries of European cranberry and their antimicrobial activity. Cesoniene L, Jasutiene I, Sarkinas A. Medicina (Kaunas). 2009;45(12):992-9

A-type cranberry proanthocyanidins and uropathogenic bacterial anti-adhesion activity. Howell AB, Reed JD, Krueger CG, Winterbottom R, Cunningham DG, Leahy M.Phytochemistry. 2005 Sep;66(18):2281-91

A high molecular mass constituent of cranberry juice inhibits helicobacter pylori adhesion to human gastric mucus. Burger O, Ofek I, Tabak M, Weiss EI, Sharon N, Neeman I.FEMS Immunol Med Microbiol. 2000 Dec;29(4):295-301

Anti-inflammatory activity of a high-molecular-weight cranberry fraction on macrophages stimulated by lipopolysaccharides from periodontopathogens. Bodet C, Chandad F, Grenier D. J Dent Res. 2006 Mar;85(3):235-9

Inhibition activity of wild berry juice fractions against Streptococcus pneumoniae binding to human bronchial cells. Huttunen S, Toivanen M, Arkko S, Ruponen M, Tikkanen-Kaukanen C. Phytother Res. 2011 Jan;25(1):122-7

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Role of cranberry juice on molecular-scale surface characteristics and adhesion behaviour of Escherichia coli. Liu Y Black MA Caron L Camesano TA. Biotechnol Bioeng 2006 Feb 5;93(2):297-305

Antioxidant and Prooxidant Activities of Elderberry (Sambucus nigra) Extract in Low-Density Lipoprotein Oxidation. Peter M. Abuja, Michael Murkovic, and Werner Pfannhauser. J. Agric. Food Chem., 1998, 46 (10), pp 4091–4096

Phenolic composition and antioxidant activities in flesh and achenes of strawberries (Fragaria ananassa). Aaby K, Skrede G, Wrolstad RE. J Agric Food Chem. 2005 May 18; 53(10):4032-40

Contents of anthocyanins and ellagitannins in selected foods consumed in Finland. Koponen, JM, Happonen AM, Mattila, PH, Torronen, AR. J Agric Food Chem. 2007, 55, 1612-1619

Berry phenolics: antimicrobial properties and mechanisms of action against severe human pathogens. Nohynek LJ, Alakomi HL, Kähkönen MP, Heinonen M, Helander IM, Oksman-Caldentey KM, Puupponen-Pimiä RH. Nutr Cancer. 2006;54(1):18-32.

The action of berry phenolics against human intestinal pathogens. Puupponen-Pimiä R, Nohynek L, Alakomi HL, Oksman-Caldentey KM. Biofactors. 2005;23(4):243-51

Flavonoid intake and coronary mortality in Finland: a cohort study. Knekt P, Jarvinen R, Hakkinen R, Reunanen A, Maatela J: BMJ 1996, 312:478-481

Contact Information

Canadean Ltd www.nutrafiles.com

Tel.: +44 (0)1256 394 200 info@nutrafiles.com Nutrafiles@canadean.com

Disclaimer: Reasonable care has been taken in preparing this document and the information provided herein is believed to be accurate. However, this information is not reviewed by any authority as EFSA or FDA.