neuroanatomy - brain mappingbrainmapping.org/nitp/images/summer2015slides/nitp2015... · 2015. 8....
TRANSCRIPT
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EXPERIMENTAL DESIGN IIMartin M. Monti
UCLA Psychology
NITP 2015
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BLOCK DESIGN
From R. Buckner, HBM2001
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SLOW EVENT RELATED DESIGN
From R. Buckner, HBM2001
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SLOW EVENT RELATED EXP OF LANGUAGE
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WHY EVENT RELATED DESIGNS?
Randomize condition/stimuli order
Cf. Confounds of blocked designs (Johnson et al., 1997)
From C. Ruff
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WHY EVENT RELATED DESIGNS?
From C. Ruff
Blocked designs may trigger expectations and cognitive sets
…
Pleasant (P)Unpleasant (U)
Event related designs can minimize expectation/strategy
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WHY EVENT RELATED DESIGNS?
Randomize condition/stimuli order
Cf. Confounds of blocked designs (Johnson et al., 1997)
Post-hoc classification of trials
e.g. According to subsequent recall (Wagner et al., 1998)
From C. Ruff
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WHY EVENT RELATED DESIGNS?
Wagner et al., 1998
fMRI Task: abstract or concrete word?
After scanning: recognition memory test
fMRI Data Analysis: Classify trials as hit (remembered)
and miss (forgotten)
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WHY EVENT RELATED DESIGNS?
Wagner et al., 1998
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WHY EVENT RELATED DESIGNS?
Randomize condition/stimuli order
Cf. Confounds of blocked designs (Johnson et al., 1997)
Post-hoc classification of trials
e.g. According to subsequent recall (Wagner et al., 1998)
Some events can only be indicated by the subject
(during the experiment)
e.g. Changes in spontaneous perception (Tong et al., 1998)
From C. Ruff
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WHY EVENT RELATED DESIGNS?
Tong et al., 1998
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WHY EVENT RELATED DESIGNS?
Tong et al., 1998
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WHY EVENT RELATED DESIGNS?
Randomize condition/stimuli order
Cf. Confounds of blocked designs (Johnson et al., 1997)
Post-hoc classification of trials
e.g. According to subsequent recall (Wagner et al., 1998)
Some events can only be indicated by the subject
(during the experiment)
e.g. Changes in spontaneous perception (Tong et al., 1998)
Some trials cannot be blocked
e.g. Odd-ball designs (Clark et al., 2000)
From C. Ruff
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WHY EVENT RELATED DESIGNS?
Clark et al., 2000
Oddball
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WHY EVENT RELATED DESIGNS?
Randomize condition/stimuli order
Cf. Confounds of blocked designs (Johnson et al., 1997)
Post-hoc classification of trials
e.g. According to subsequent recall (Wagner et al., 1998)
Some events can only be indicated by the subject
(during the experiment)
e.g. Changes in spontaneous perception (Tong et al., 1998)
Some trials cannot be blocked
e.g. Odd-ball designs (Clark et al., 2000)
Better model for blocked stimuli too?
e.g. State-item interactions (Chawla et al., 1999)
From C. Ruff
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WHY EVENT RELATED DESIGNS?
“Event” model may capture state-item interactions (with longer SOAs)
“Epoch” model assumes constant neural processes throughout block
U1 U2 U3 P1 P2 P3
P1 P2 P3U1 U2 U3Data
ModelChawla et al., 1999
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WHAT/WHEN/WHERE IS THE EVENT?
The man returned to his home was happy
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WHY NOT EVENT RELATED DESIGNS?
Blocked designs are statistically more powerful
Some psychological processes are difficult to switch
on/off, better in blocks
e.g., starting and stopping mental imagery
Excessively complicated designs might confuse the
subject
From C. Ruff
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RAPID EVENT RELATED DESIGN
From R. Buckner, HBM2001
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SLOW EVENT RELATED EXP OF LANGUAGE
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FAST EVENT RELATED
More trials, same
experiment length!
But, hemodynamic
response of different
events now overlaps.
→ How to tease apart
which part of the response
comes from which event?
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ASSUMPTION: LINEAR SYSTEM
System = input → output
Neural activity → fMRI signal
A system is linear if it has two features:
1. Scaling
2. Superposition
If a system is linear we can add/subtract
responses coming from contiguous trials
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ASSUMPTION I: SCALING
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Data from Robert Savoy and Kathleen O’Craven (25).
CAN WE ASSUME SCALING (I)?
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Robson et al., 1998
CAN WE ASSUME SCALING (II)?
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ASSUMPTION II: SUPERPOSITION
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CAN WE ASSUME SUPERPOSITION (I)?
Dale and Buckner, Hum. Brain Map., 1997
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CAN WE ASSUME SUPERPOSITION (II)?
Dale and Buckner, Hum. Brain Map., 1997
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CAN WE ASSUME SUPERPOSITION (II)?
Dale and Buckner, Hum. Brain Map., 1997
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CAN WE ASSUME SUPERPOSITION (II)?
Dale and Buckner, Hum. Brain Map., 1997
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CAN WE ASSUME SUPERPOSITION (II)?
Dale and Buckner, Hum. Brain Map., 1997
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CAN WE ASSUME SUPERPOSITION (III)?
EFFECTS OF PRESENTATION RATE
Friston et al., 1998
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Zhang et al., 2008
CAN WE ASSUME SUPERPOSITION (IV)?
EFFECTS OF ISI
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Huettel & McCarthy 2001
DIFFERENT AREA DIFFERENT NON-LINEARITY
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1. Trial order: shuffle things around
With rapid ER-fMRI, it is important that different trial types follow each other equally
Statistical (multicollinearity) & psychological reasons
Early studies used counterbalancing
Must be done to several orders depending upon trial length
Recent studies have used randomization (full/pseudo)
Works fine with large enough # of trials
HOW TO TEASE APART DIFFERENT TRIALS?
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2. ISI Jitter/Randomization
HOW TO TEASE APART DIFFERENT TRIALS?
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2. ISI Jitter/Randomization
HOW TO TEASE APART DIFFERENT TRIALS?
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TEASING APART SEQUENTIAL PROCESSES
D’Esposito et al.
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NESTED/MIXED DESIGNS
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12^])([ˆ
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cXXccVar
AvBestimateXce
TTT
EFFICIENCY
A numerical value that captures the relative
ability of a design to detect an effect of
interest.
Say you are interested in the difference
between two tasks, A & B.
Av.Bestimatevar
Av.Bestimatet
Noise
Contrast of interest
Experimental design
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EFFICIENCY: EXAMPLES
X Matrix: Task A, Task B, Mean
Contrasts of interest:
i. Direct comparison [1 -1 0]
ii. Estimation of each effect against baseline [1 0
0], [0 1 0]
Randomize or not?
Event related or block?
Use rest periods in between blocks?
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Design df e(c,X) 1 -1 0 1 0 0 0 1 0
Fix 100-3 0.31 1.35 0.80 0.83
Rdm 100-3 1.32 3.05 4.47 4.84
R
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Design df e(c,X) 1 -1 0 1 0 0 0 1 0
Block 100-3 4.80 13.39 15.09 14.84
Rdm 100-3 1.32 3.05 4.47 4.84
R
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Design df e(c,X) 1 -1 0 1 0 0 0 1 0
No Rest 80-3 1.00 20.92 2.12 2.09
Rest 160-3 8.46 20.85 28.47 28.45
N
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GOOD PRACTICES
(BUT YOUR EXPERIMENT MAY DIFFER … )
Bigger IS better: more trials, more TRs, more Ss.
ALWAYS counterbalance/randomize/pseudo-randomize your events!
Ask yourself questions:
What's the best design for my cog process of interest?
What's the best design for my task(s)?
What psychological factors might be at play?
What comparison(s) are you interested in?
Maximize efficiency for your contrast(s) of interest, compare multiple
designs, simulate!
Be considerate: For how long do you think you can get good data out
of a volunteer?