nano fusion technologies overview)

1

Nano Fusion Technologies, Inc.

April 2009

Introduction to

micro Electro-osmotic (EO) pumps

& micro-fluidic technologies

Nano Fusion Technologies, Inc. Founders and Managements

Tihiro Ohkawa (Founder)

Masana Nishikawa (Founder)

Ichiro Yanagisawa (CEO/CTO)

Masataka Ogawa (VP, Business Development)

Major Shareholders (Founders & VCs)

Yasuda Enterprise Development Co., Ltd (Japan)

Conduit Ventures Limited (UK)

4 Japanese VCs

Founded: March 15, 2004

Capital: 229,750,000 yen

Headquarters: 2-21-7, Naka-cho, Meguro-ku, Tokyo, Japan

Laboratory: B-M202 Collaborative Research Bldg. (CCR)Institute of Industrial Science, the University of Tokyo

2Nano Fusion Technologies, Inc.

Objective

NFT Objective: Offer micro fluid delivery solutions with unique micro pumps and micro-fluidic control devices to advance bio-science and micro-electronics functions.

Major Technologies: Micro electro-osmotic pump (Micro EO pumps)

Micro-fluidic control devices and systems

Application Area: Bio-Science, Environmental and Chemical Applications

mTAS / Analytical device

Pipetting / Dispensing

Drug delivery (infusion) Micro Electronics

Micro Fuel Cell & others

Industrial (lubrication, etc.)


Principle of micro EO pump- Electro-osmotic Pump -

Nano Fusion Technologies, Inc. 4

Liquid

Porous

ceramic

disc

(dielectric

material)

Liquid

Electrodes

Voltage

Nozzle Pumping

EOF

Inside ceramic disc

Ele

ctric

field

Liquid

Porous

material

Interface

Ele

ctric

field

Flo

w

Dielectric material (Ceramics)

I. Negative charges on the dielectric material surface.

II. Excessive positive charges generated in the liquid

near the liquid-ceramics interface.

III. The applied electric field would force the positively

charged liquid layer to flow, that drags the whole

liquid.

Electro-osmotic flow (EOF)

Electro-osmotic Flow (EOF)-generating mechanism Liquid

Ceramic particle

4

Features of Micro EO pump


Typical pump performances


RP3-N1/N2

RP5A-RL-N311/N610

RP5A-SP-N311/N610

Overall Coverage

Flow Rate (mL/min) Pressure (kPa)

7B-SP-N311/N610

LFHP

10-1 1 10 102 103 10 102 1031

RP5A-RL (evaluation sample)

Model RP5A-RL-N311 RP5A-RL-N610

Pumping principle1) Electro-osmosis

Max.Flow rate2)

@DC 24V5)

110μ L/min 190μ L/min

Max.Pressure3) 140 kPa 110 kPa

Power

consumption4)

13 mW 100mW

Working liquid Methanol De-ionized water

Material Polypropylene(Body・Nozzle・Reservior)

Size Diameter 8mm,length 3.5mm(Body)

Reservior capacity 1.2mL

Weight 0.5g


Performance of RP5A-RL-N311

0

20

40

60

80

100

120

140

160

0 50 100 150 200

12V

18V

24V

30V

Performance of RP5A-RL-N610

0

50

100

150

200

250

300

0 50 100 150

Back pressure (kPa)

Flo

w r

ate

(μL/m

in)

12V

18V

24V

30V

Back pressure (kPa)

Flo

w r

ate

(μL/m

in)

LFHP (evaluation sample)- For high pressure or extremely low flow rate -

Model LFHP

Pumping principle1) Electro-osmosis

Max.Flow rate2)

@DC 60V5)

8μL/min

Max.Pressure3) 2000kPa

Power consumption4) 15mW

Working liquid De-ionized water

Material PPS

Body size Diameter 10.3mm,length 27.3mm

Nozzle port Upchurch NanoPort Assemblies

F-333Nx

Nozzle fitting Upchurch NanoPort Assemblies

N-333-01

Weight 1.8g

1) High pressure performance up to 2,000kPa (at 60 Volts)

2) Extremely low flow rate (around 100 nL/min)

3) Standard fitting design compatible with Upchurch fitting

4) Extendable reservoir design

Working liquid:

De-ionized water


Performance of LFHP

0

1

2

3

4

5

6

7

8

9

0 1000 2000 3000

Back pressure (kPa)

Flo

w r

ate

(μL/m

in)

24V

60V

Model PS-PWM-24 PS-PWM4C-24

Output voltage1) 24V max

Duty ratio 0～100%

Pulse-frequency Variable (10～2000Hz)

Resolution of voltage 6mV

Power supply USB bus power AC adaptor

Input 100-240V 50/60Hz 0.3A

Output DC5V 2A

Output current 50mA max 50mAmax/1 channel

Number of I/O channel 1 4

Size(W×D×H) 85×55×21mm 85×55×48mm

Enable stable micro-flow

by micro Electro-osmotic pump

1) PWM power source

2) Easy operation from Personal Computer

3) Built-in Feedback Control Function

PWM Power Source and Controller

for Micro EO Pump (PS-PWM-24)


Evaluation Kits for micro EO pump

Power supply PS-PWM4C-24

FilterLFHP

Reservoir

Reservoir

Flow sensor LG16-0025AConnecter

Connecter

Low flow/High pressure kits EVK-001 formation

Power supply PS-PWM-24

Flow sensor LG16-1000A

RP20-SP

Reservoir for RP20-SP

Tube (Teflon)

Tube (Teflon)

High flow kits EVK-003 formation

Evaluation Kits for full EO pump testing

Include all necessary components (pumps, power supply, flow sensor,

reservoirs and so on)

Evaluation Kits for different flow rate ranges Low flow/High pressure kits (EVK-001) 0.1-1.5μL/min (-2000kPa)

Middle flow kits (EVK-002) 5-50μL/min

High flow kits (EVK-003) 100-1000μL/min


12Nano Fusion Technologies, Inc. 12

EO Pumps on a Micro-Channel Chip

Basic Concept

Direct mount on micro-channel chips (Pump-on-chip)

Integrated pump (Reservoir-on-pump)

EO Pump

Reservoir

Micro-channel chip

Less redundant space

Less sample fluid

Precise flow rate &

flow amount control

EO pump applications

for Microfluidics I


EO pump applications

for Microfluidics II


Thank You

Nano Fusion Technologies, Inc.Headquarters: (Mailing address)

Nano Fusion Technologies, Inc.

2-21-7 Naka-cho, Meguro-ku, Tokyo 153-0065

JAPAN

e-mail: [email protected]

Website: http://www.nft-eop.co.jp/

Laboratory:

B-M202 Collaborative Research Bldg. (CCR)

Institute of Industrial Science, the University of Tokyo

4-6-1 Komaba, Meguro-ku, Tokyo 153-8505

JAPAN

TEL: +81-3-5452-6619 FAX: +81-3-5452-6620


mailto:[email protected]





http://www.nft-eop.co.jp/

