ischemic and infectious colitis - ucsf cme diagnosis • ulcerative colitis – history, endoscopy...
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Ischemic and Infectious Colitis
Emily Finlayson, MD, MSUCSF Post Graduate Course in
General SurgeryMarch 23, 2011
Ischemic Colitis• Most common form of intestinal
ischemia– Lowest blood flow in GI tract– Relies on collateral flow– Does not autoregulate well
• Often occurs in hospitalized patients
• High index of suspicion
ELDER K et al. Cleveland Clinic Journal of Medicine, 2009.
Etiology• Idiopathic• Vascular occlusion
– Embolus, thrombosis– Hypercoagulable state– Surgery
• Systemic vascular disorders• Low flow (CHF, sepsis, hypovolemia)• Obstruction, impaction, volvulus• Medications
– Diurestics, beta-blockers, cocaine
Classification
Non-gangrenous (80%-85%)
Gangenous (15%-20%)
Chronic, nonreversible
Transient, reversible
Chronic colitis (20%-25%)
Stricture (10%-15%)
Presentation• Most patient over 60• Non-gangrenous
– Abdominal pain, diarrhea, hematochezia– Low grade fever– Heme + stool– Moderate WBC elevation with left shift
• Full thickness gangrene– Sepsis and shock
Diagnosis• Abdominal XR
– Free air, air in bowel wall, portal venous gas
• CT– Often non-specific thickening
Diagnosis• Abdominal XR
– Free air, air in bowel wall, portal venous gas
• CT– Often non-specific thickening
• NO barium enema!!
Diagnosis• Endoscopy
– Low pressure– Helpful in evaluating severity
Hemorrhagic Nodules
Diagnosis• Endoscopy
– Low pressure– Helpful in evaluating severity
• Angiography NOT helpful
Management
ELDER K et al. Cleveland Clinic Journal of Medicine, 2009.
Infectious Colitis• Pseudomembranous colitis
– Associated with virtually all antibiotics• Higher incidence
– Cephalosporins– Penicillins– Clindamycin
• Lower incidence– Aminoglycosides– Quinolones
• You only need one dose• Yes…even Flagyl
Pseudomembranous Colitis• Asymptomatic carriers
– 1%-3% general population– 20%-40% hospitalized adults– 50% long term care facilities
• Spores can survive weeks to month• On your stethoscope, for example
Pseudomembranous Colitis• Pathophysiology
– Toxins (A&B) bind to intestinal receptors– Inflammation and diarrhea
• New virulent strain• NAP1/BI/07• Previously uncommon, now epidemic• Severe disease in low risk patients
Pseudomembranous Colitis• High risk groups
– Drugs• Antibiotics• PPI• Valacyclovir
– IBD – Serious acute illness– GI procedures– Advanced age– Immunosuppressed– Post-partum (91% received antibiotic)
•
Pseudomembranous Colitis• Other risk factors
– Drugs• Antibiotics• PPI (RR 4.17)• Valacyclovir
– Prolonged hospital stay– Hypoalbuminemia– Low levels of anti-toxin and B antibodies
•
Differential Diagnosis• Ulcerative colitis
– History, endoscopy• Crohn’s disease
– History, endoscopy• Ischemic colitis
– More bleeding, risk factors, endoscopy• Amebic dysentery
– Bloody diarrhea, travel history, stool micro
Diagnosis• History
• Enzyme immunoassay for toxin A&B– 73% sensitivity, 98% specificity
• Endoscopy?– Assay negative but high suspicion– Need diagnosis before assay done– Failure of initial medical therapy
Initial Medical TherapyStool C Diff x 3 for Toxin A, B
Observe if mild symptoms Begin therapy prior to results if disease mod/severe
C Diff +
Endoscopy for diagnosis Continue therapy
C Diff -
Initial Medical TherapyAssess disease severity
Mild/moderate Severe
Vancomycin 125 mg QID + Flagyl
Flagyl 5oo mg TID for 10-14 days or vancomycin if epidemic
What is Severe Disease?• Organ failure• WBC > 15K• Cr > 2.3 mg/L• Hypoalbuminemia• Pancolitis on imaging• Megacolon• Risk groups
– Elderly, multimorbid, immunocompromised
Start Heading to the OR• WBC >= 20• Lactate >=5• Age >=75• Immunosuppression• Shock, vasopressors• Toxic megacolon• MOSF