influenza virus vaccine/tetanus vaccine

Reactions 612 - 3 Aug 1996 Influenza virus vaccine/tetanus vaccine Bullous pemphigoid in elderly patients: 2 case reports A man and a woman, both aged 84 years, developed bullous pemphigoid shortly after they received influenza virus vaccine [‘Previgrip’] and tetanus vaccine, respectively. The man developed a blistering eruption with tense blisters on his palms and soles and urticarial lesions on his trunk the day after his vaccination. The woman developed pruritus 24 hours after her vaccination and a generalised blistering eruption developed 1 month later. Histology of skin lesions from both patients showed subdermal bulla with linear deposition of IgG and C3 along the basement membrane zone. Circulating anti-basement membrane zone antibodies were detected in both patients. Their symptoms responded to treatment with clobetasol. Author comment: ‘The mechanism of induction of bullous pemphigoid by vaccination is not clear. Vaccination could reveal a subclinical bullous pemphigoid by enhancing the autoimmune response: this may be related to bullous pemphigoid "induced" by infections.’ Fournier B, et al. Bullous pemphigoid induced by vaccination. British Journal of Dermatology 135: 153-154, Jul 1996 - France 800456124 1 Reactions 3 Aug 1996 No. 612 0114-9954/10/0612-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved

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Reactions 612 - 3 Aug 1996

Influenza virus vaccine/tetanus vaccine

Bullous pemphigoid in elderly patients: 2 casereports

A man and a woman, both aged 84 years, developed bullouspemphigoid shortly after they received influenza virus vaccine[‘Previgrip’] and tetanus vaccine, respectively.

The man developed a blistering eruption with tense blisterson his palms and soles and urticarial lesions on his trunk theday after his vaccination. The woman developed pruritus 24hours after her vaccination and a generalised blisteringeruption developed 1 month later. Histology of skin lesionsfrom both patients showed subdermal bulla with lineardeposition of IgG and C3 along the basement membrane zone.Circulating anti-basement membrane zone antibodies weredetected in both patients. Their symptoms responded totreatment with clobetasol.

Author comment: ‘The mechanism of induction of bullouspemphigoid by vaccination is not clear. Vaccination couldreveal a subclinical bullous pemphigoid by enhancing theautoimmune response: this may be related to bullouspemphigoid "induced" by infections.’Fournier B, et al. Bullous pemphigoid induced by vaccination. British Journal ofDermatology 135: 153-154, Jul 1996 - France 800456124

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