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    The outer coatwhich is

    transparent

    anteriorly iscalled the

    cornea.

    The white andopaque coat is

    the sclera.

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    A rich vascular coat (the choroid) lines the posterior

    segment of the eye and nourishes the retina at its inner

    surface.

    The ciliary body lies anteriorly. It contains the smooth

    ciliary muscle whose contraction alters lens shape and

    enables the focus of the eye to be changed.The ciliary

    epithelium secretes aqueous humour and maintains the

    ocular pressure. The ciliary body provides attachment for

    the iris.

    The lens lies behind the iris and is supported by finefibrils (the zonule)

    running between the lens and the ciliary body.

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    The angle formed by the iris and cornea (the

    iridocorneal angle) is lined by a meshwork of

    cells and collagen beams (the trabecular

    meshwork).

    In the sclera outside this, Schlemmscanal

    conducts the aqueous humour from the anterior

    chamber into the venous system, permitting

    aqueous drainage. This region is termed the

    drainage angle.

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    Between the cornea anteriorly and the lensand iris posteriorly lies the anterior chamber.

    Between the iris, the lens and the ciliary body

    lies the posterior chamber (which is distinct

    from the vitreous body). Both these chambers

    are filled with aqueous humour. Between the

    lens and the retina lies the vitreous body.

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    The eye lies within the bony orbit whose hasthe shape of a four-sided pyramid. At its

    posterior apex is the optic canal which

    transmits the optic nerve to the brain. The

    superior and inferior orbital fissures allow thepassage of blood vessels and cranial nerves

    which supply orbital structures. On the anterior

    medial wall lies a fossa for the lacrimal sac. The

    lacrimal gland lies anteriorly in thesuperolateral aspect of the orbit.

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    provide mechanical protection to the anteriorglobe.

    secrete the oily part of the tear film.

    spread the tear film over the conjunctiva and

    cornea.

    prevent drying of the eyes.

    contain the puncta through which the tears

    drain into the lacrimal drainage system.

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    A surface layer of skin.

    The orbicularis muscle.

    A tough collagenous layer (the tarsal plate).

    An epithelial lining, the conjunctiva, reflected

    onto the globe.

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    The levator muscle passes forwards to the

    upper lid and inserts into the tarsal plate. Itis innervated by the third nerve. Damage to

    the nerve or changes in old age result in

    drooping of the eyelid (ptosis). A flat smoothmuscle arising from the deep surface of the

    levator inserts into the tarsal plate. It is

    innervated by the sympathetic nervous

    system.

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    If the sympathetic supply is damaged (as in

    Horners syndrome) a slight ptosis results.

    The margin of the eyelid is the site of the

    mucocutaneous junction. It contains the

    openings of the meibomian oil glands which

    are located in the tarsal plate. These secretethe lipid component of the tear film. Medially,

    on the upper and lower lids, two small puncta

    form the initial part of thelacrimal drainage system.

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    Tears drain into the upper and lower puncta andthen into the lacrimal sac via the upper and lower

    canaliculi. They form a common canaliculus before

    entering the lacrimal sac. The nasolacrimal duct

    passes from the sac to the

    nose. Failure of the distal part of the nasolacrimal

    duct to fully canalize at birth is the usual cause of

    a watering, sticky eye in a baby.Tear drainage is an

    active process. Each blink of the lids helps to pump

    tears through the

    system.

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    (10im thick) covers the

    external ocular surface andcomprises three

    layers: a thin mucin layer in contact with the

    ocular surface and produced mainly by

    the conjunctival goblet cells; an aqueous layer produced by the

    lacrimal gland;

    a surface oil layer produced by the tarsalmeibomian glands and delivered to the

    lid margins.

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    it provides a smooth air/tear interface fordistortion free refraction of light at the cornea

    it provides oxygen anteriorly to the avascular

    cornea

    it removes debris and foreign particles from the

    ocular surface through the flow of tears

    it has antibacterial properties through the

    action of lysozyme, lactoferrin and the

    immunoglobulins, particularly secretory IgA.

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    is 0.5 mm thick and comprises:

    The epithelium, an anterior squamous layer thickenedperipherally at the limbus where it is continuous with the

    conjunctiva.The limbus houses its germinativeor

    stemcells.

    An underlying stroma of collagen fibrils, ground

    substance and fibroblasts. The regular packing and small

    diameter of the collagen fibrils accounts for corneal

    transparency.

    The endothelium, a monolayer of non-regenerating cells

    which actively pumps ions and water from the stroma to

    control corneal hydration and transparency.

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    The difference between the regenerative

    capacity of the epitheliumand endotheliumis

    important. Damage to the epithelial layer, by

    an abrasion for example, is rapidly repaired.

    Endothelium, damaged by disease

    or surgery, cannot be regenerated. Loss of its

    barrierand pumping functions leads tooverhydration, distortion of the regular

    packing of collagen fibres and corneal

    clouding.

    The functions of the cornea are as follows: it refracts light and together with the lens,

    focuses light onto the retina;

    it protects the internal ocular structures.

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    is formed from interwovencollagen fibrils of different widths

    lying within a ground substance

    and maintained by fibroblasts.

    is of variable thickness, 1imm

    around the optic nerve head and

    0.3imm just posterior to the muscleinsertions.

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    is formed of arterioles, venules and a densefenestrated capillary network.

    is loosely attached to the sclera.

    has a high blood flow.

    nourishes the deep, outer layers of the retina and

    may have a role in its temperature homeostasis.

    Its basement membrane together with that of the

    retinal pigment epithelium (RPE) forms the

    acellular, Bruchs membrane, which acts as a

    diffusion barrier between the choroid and theretina.

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    The retinal pigment epithelium (RPE):

    is formed from a single layer of cells.

    is loosely attached to the retina except at the

    periphery (ora serrata) and around the optic

    disc.

    forms microvilli which project between and

    embrace the outersegment discs of the rods and

    cones.

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    phagocytoses the redundant external

    segments of the rods and cones.

    facilitates the passage of nutrients and

    metabolites between the retina and

    choroid.

    takes part in the regeneration of rhodopsin

    and cone opsin, the photoreceptor visual

    pigments recycling vitamin A.

    melanin granules absorb scattered light.

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    Rods are

    responsible for

    night vision.Theyare sensitive to

    light and do

    not signal

    wavelengthinformation

    (colour). They

    form the large

    majority

    of photoreceptorsin the remaining

    retina.

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    This is subdivided into three parts:

    the ci l iary muscle.

    the ciliary processes (pars p l icata.

    the pars plana.

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    THECILIARYMUSCLE

    This:

    Comprises smooth muscle arranged in a ring

    overlying the ciliary processes.

    Is innervated by the parasympathetic system via

    the third cranial nerve.

    Is responsible for changes in lens thickness and

    curvature during accommodat ion. The zonular

    f ibres supporting the lens are under tensionduring distant viewing. Contraction of the muscle

    relaxes them and permits the lens to increase its

    curvature and hence its refractive power.

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    (PARS

    PLICATA)

    There are about 70 radial ci l iary processes arranged

    in a ring around the posterior chamber.They are

    responsible for the secretion of aqueous humour.

    Each ciliary process is formed by an epithelium

    two layers thick (the outer pigmented and inner

    non-pigmented) with a vascular stroma.

    The stromal capillaries are fenestrated, allowing

    plasma constituentsready access.

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    The t igh t junct ions between the non-

    pigmented epithelial cells provide a barrierto free diffusion into the posterior

    chamber.They are essential for the active

    secretion of aqueous by the non pigmental

    cells.

    The epithelial cells show marked infolding,

    which significantly increasestheir surfacearea for fluid and solute transport.

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    This comprises a relatively avascular

    stroma covered by an epithelial layer two

    cells thick.

    It is safe to make surgical incisions

    through the scleral wall here to gain

    access to the vitreous cavity.

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    In the orbit the optic nerve is

    surrounded by a sheath formed bythe dura, arachnoid and pia mater

    continuous with that surrounding

    the brain.It is bathed in

    cerebrospinal fluid.

    The central retinal artery and vein

    enter the eye in the centre of theoptic nerve.

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    All of the extraocular muscles, with the exceptionof the inferior oblique, form a cone within the

    bony orbit

    The apex of the cone is in the posterior aspect(back) of the orbit, while the base of the cone is

    the attachment of the muscles around the midline

    of the eye. This conic structure is referred to as

    the annulus of Zinn,and within this cone runs

    the Optic nerve(cranial nerve II)

    Within the optic nerve are the ophthalmic arteryand the ophthalmic vein

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    The superior oblique muscle is different from the

    others, because before it attaches to the eye, itpasses through a ring-like tendon, the trochlea,

    which acts like a pulley in the nasal portion of the

    orbit

    The inferior oblique muscle (not a member of theannulus of Zinn) arises from the lacrimal fossain

    the nasal portion of the bony orbit and attaches tothe inferior portion of the eye

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    The primary muscle that moves an eye in a givendirection is known as the agonist

    A muscle in the same eye that moves the eye in

    the same direction as the agonist is known as asynergist

    A muscle in the same eye that moves the eye in

    the opposite direction of the agonist is the

    antagonist

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    Cardinal positions of gaze

    Up/right Up/left

    Right

    Left Down/right

    Down/left

    In each position of gaze, one muscle of each eye isthe primary mover of that eye, and is yoked to

    the primary mover of the other eye

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    A vergence or disconjugate movementinvolves simultaneous movement of both eyes in

    the opposite directions

    There are two principal vergence movements Convergenceboth eyes moving nasally or

    inward

    Divergenceboth eyes moving temporally or

    upward

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    Right eyeThe nose

    SR

    SO

    IO

    IR

    MRLR

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