Egyptian Candidates Ahmed Faramawy T.A in ASU, Cairo, Egypt Hadeer ELHabashy TA in AUC, Cairo, Egypt Mostafa Abo Elsoud National Research Center Supervised

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<ul><li> Slide 1 </li> <li> Slide 2 </li> <li> Slide 3 </li> <li> Egyptian Candidates Ahmed Faramawy T.A in ASU, Cairo, Egypt Hadeer ELHabashy TA in AUC, Cairo, Egypt Mostafa Abo Elsoud National Research Center Supervised By Marina lyashko &amp; SvetLana Accenova </li> <li> Slide 4 </li> <li> The SOS response in Escerichia coli bacteria is a set of inducible physiological reactions that help a cell to servive after the treatment with various DNA-damaging agents, such as ultraviolet and ionizing radiation and some chemicals. More than 40 genes are induced in response to DNA damage as part of the SOS regulon in Escherichia coli. SOS repair may result in SOS mutagenesis due to the inhibition of the proofreading activity of the epsilon subunit of DNA Pol III. </li> <li> Slide 5 </li> <li> SOS gene box Umuc, UmuD, DinI Lex A RecA Pyrimidine photodimers </li> <li> Slide 6 </li> <li> .. umuC umuD LexA ssDNA+RecA+ATP RecA* dinI UmuC DinI UmuD UmuD2 UmuD2 UmuDD UmuD2CUmuD2CUmuDDC Pol V UmuD </li> <li> Slide 7 </li> <li> Mathematical Model of SOS-induced mutagenesis in bacteria Escherichia coli under ultraviolet irradiation By: Hadeer El Habashy </li> <li> Slide 8 </li> <li> Contents 1.Why?, Why?, Why? And why? 2. Developing Mathematical model </li> <li> Slide 9 </li> <li> Mathematical Model WHY? of SOS-induced mutagenesis WHY? in bacteria Escherichia coli under WHY? ultraviolet irradiation &amp; WHY? </li> <li> Slide 10 </li> <li> Object for study Escherichia coli bacteria colibacillus cells play an important role among the traditional biological objects used for studying the fundamental mechanisms of induced mutagenesis. Using these cells as an object of study allows us to study the structural and functional organization of the genetic apparatus and the biochemical processes controlling the mutation process in details. </li> <li> Slide 11 </li> <li> T-T and T-C dimers: bases become cross-linked, T-T more prominent, caused by UV light (UV- C(</li></ul>

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