8/2/2019 multifocal anaplastic oligoastrocytoma

1/13

Casediscussions

DrSubhashKumarMD,DMAssociateConsultant Neuroradiology

8/2/2019 multifocal anaplastic oligoastrocytoma

2/13

3

1

years

old

male

k/c/oGilbertsyndrome45years Suddenonsetgiddinesson06/12/2011

Progressiveneurological

deterioration

AdmittedatSBAMItracheostomised,stablevitals

8/2/2019 multifocal anaplastic oligoastrocytoma

3/13

8/2/2019 multifocal anaplastic oligoastrocytoma

4/13

8/2/2019 multifocal anaplastic oligoastrocytoma

5/13

8/2/2019 multifocal anaplastic oligoastrocytoma

6/13

8/2/2019 multifocal anaplastic oligoastrocytoma

7/13

8/2/2019 multifocal anaplastic oligoastrocytoma

8/13

8/2/2019 multifocal anaplastic oligoastrocytoma

9/13

Gliomatosis

cerebri

Multifocalglioma

8/2/2019 multifocal anaplastic oligoastrocytoma

10/13

Anaplastic

Oligoastrocytoma

8/2/2019 multifocal anaplastic oligoastrocytoma

11/13

8/2/2019 multifocal anaplastic oligoastrocytoma

12/13

NeuroepithelialTumorofUncertainOrigin At

least

two

lobes

(esp.

cortex)

may

be

diffusely

infiltratedwitharelativelackofmasseffectanddistortion(i.e.,preservationofneuronal

architecture)

Peakage

is

40

to

50

years,

but

occur

in

all

adult

agegroups. WHOclassificationisgradeIII.

Itis

not

uncommon

to

have

the

frontal

and

temporallobesinvolvedwiththebasalgangliaandthalami.

8/2/2019 multifocal anaplastic oligoastrocytoma

13/13

The neurob io logy o f g l i om as : f rom cel l b io logy to t he deve lopm ent o f th e rapeu t i c approachesManfred Westphal & Katrin Lamszus. Nature Reviews Neuroscience1 2 , 495-508 (September 2011)

doi:10.1038/nrn3060