multifocal anaplastic oligoastrocytoma

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    Casediscussions

    DrSubhashKumarMD,DMAssociateConsultant Neuroradiology

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    3

    1

    years

    old

    male

    k/c/oGilbertsyndrome45years Suddenonsetgiddinesson06/12/2011

    Progressiveneurological

    deterioration

    AdmittedatSBAMItracheostomised,stablevitals

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    Gliomatosis

    cerebri

    Multifocalglioma

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    Anaplastic

    Oligoastrocytoma

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    NeuroepithelialTumorofUncertainOrigin At

    least

    two

    lobes

    (esp.

    cortex)

    may

    be

    diffusely

    infiltratedwitharelativelackofmasseffectanddistortion(i.e.,preservationofneuronal

    architecture)

    Peakage

    is

    40

    to

    50

    years,

    but

    occur

    in

    all

    adult

    agegroups. WHOclassificationisgradeIII.

    Itis

    not

    uncommon

    to

    have

    the

    frontal

    and

    temporallobesinvolvedwiththebasalgangliaandthalami.

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    The neurob io logy o f g l i om as : f rom cel l b io logy to t he deve lopm ent o f th e rapeu t i c approachesManfred Westphal & Katrin Lamszus. Nature Reviews Neuroscience1 2 , 495-508 (September 2011)

    doi:10.1038/nrn3060