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    1

    DESIGN OF EXPERIMENTS

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    Role of DOE in Process Improvement

    DOE is a formal matematical meto! fors"stematicall" plannin# an! con!$ctin# scientific

    st$!ies tat can#e e%perimental varia&les

    to#eter in or!er to !etermine teir effect of a

    #iven response'

    DOE ma(es controlle! can#es to inp$t

    varia&les in or!er to #ain ma%im$m amo$nts of

    information on ca$se an! effect relationsips

    )it a minim$m sample si*e'

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    Role of DOE in Process Improvement

    DOE is more efficient tat a stan!ar!

    approac of can#in# ,one varia&le at a

    time- in or!er to o&serve te varia&le.s

    impact on a #iven response'

    DOE #enerates information on te effect

    vario$s factors ave on a response varia&lean! in some cases ma" &e a&le to !etermine

    optimal settin#s for tose factors'

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    Role of DOE in Process Improvement

    DOE enco$ra#es ,&rainstormin#- activities

    associate! )it !isc$ssin# (e" factors tat ma"

    affect a #iven response an! allo)s te

    e%perimenter to i!entif" te ,(e"- factors forf$t$re st$!ies'

    DOE is rea!il" s$pporte! &" n$mero$s statisticalsoft)are pac(a#es availa&le on te mar(et'

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    SI3 STEPS IN DOE

    Fo$r elements associate! )it DOE4

    1' Te !esi#n of te e%periment5

    2' Te collection of te !ata5

    +' Te statistical anal"sis of te !ata5 an!

    /' Te concl$sions reace! an!recommen!ations ma!e as a res$lt of te

    e%periment'

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    6

    TERMINO7OG8

    Replication 9 repetition of a &asic

    e%periment )ito$t can#in# an" factor

    settin#s5 allo)s te e%perimenter to estimate

    te e%perimental error :noise; in te s"stem$se! to !etermine )eter o&serve!

    !ifferences in te !ata are ,real- or ,

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    TERMINO7OG8

    'Ran!omi*ation 9 a statistical tool $se! to minimi*epotential $ncontrolla&le &iases in te e%periment &"

    ran!oml" assi#nin# material5 people5 or!er tat

    e%perimental trials are con!$cte!5 or an" oterfactor not $n!er te control of te e%perimenter'

    Res$lts in ,avera#in# o$t- te effects of te

    e%traneo$s factors tat ma" &e present in or!er to

    minimi*e te ris( of tese factors affectin# te

    e%perimental res$lts'

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    TERMINO7OG8

    loc(in# 9 tecni?$e $se! to increase teprecision of an e%periment &" &rea(in# te

    e%periment into omo#eneo$s se#ments

    :&loc(s; in or!er to control an" potential

    &loc( to &loc( varia&ilit" :m$ltiple lots of

    ra) material5 several sifts5 several

    macines5 several inspectors;' n" effects

    on te e%perimental res$lts as a res$lt of te&loc(in# factor )ill &e i!entifie! an!

    minimi*e!'

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    TERMINO7OG8

    3onfo$n!in# A concept tat &asicall" means tat

    m$ltiple effects are tie! to#eter into one parenteffect an! cannot &e separate!' For e%ample5

    1' T)o people flippin# t)o !ifferent coins )o$l!

    res$lt in te effect of te person an! te effect of

    te coin to &e confo$n!e!

    2' s e%periments #et lar#e5 i#er or!er

    interactions :!isc$sse! later; are confo$n!e! )it

    lo)er or!er interactions or main effect'

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    1B

    TERMINO7OG8

    Factors 9 e%perimental factors orin!epen!ent varia&les :contin$o$s or

    !iscrete; an investi#ator manip$lates to

    capt$re an" can#es in te o$tp$t of te

    process' Oter factors of concern are tose

    tat are $ncontrolla&le an! tose )ic are

    controlla&le &$t el! constant !$rin# te

    e%perimental r$ns'

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    11

    TERMINO7OG8

    Responses 9 !epen!ent varia&le meas$re!to !escri&e te o$tp$t of te process'

    Treatment 3om&inations :r$n; 9e%perimental trial )ere all factors are set

    at a specifie! level'

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    12

    TERMINO7OG8

    Fi%e! Effects Mo!el A If te treatmentlevels are specificall" cosen &" tee%perimenter5 ten concl$sions reace!)ill onl" appl" to tose levels'

    Ran!om Effects Mo!el 9 If te treatmentlevels are ran!oml" cosen from apop$lation of man" possi&le treatment

    levels5 ten concl$sions reace! can &ee%ten!e! to all treatment levels in tepop$lation'

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    1+

    P7NNING DOE

    Ever"one involve! in te e%periment so$l!ave a clear i!ea in a!vance of e%actl" )at

    is to &e st$!ie!5 te o&

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    P7NNING DOE

    Select a responseC!epen!ent varia&le:varia⩽ tat )ill provi!e information

    a&o$t te pro&lem $n!er st$!" an! te

    propose! meas$rement meto! for tisresponse varia&le5 incl$!in# an

    $n!erstan!in# of te meas$rement s"stem

    varia&ilit"

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    P7NNING DOE

    Select te in!epen!ent varia&lesCfactors:?$antitative or ?$alitative; to &e

    investi#ate! in te e%periment5 te n$m&er

    of levels for eac factor5 an! te levels ofeac factor cosen eiter specificall" :fi%e!

    effects mo!el; or ran!oml" :ran!om effects

    mo!el;'

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    P7NNING DOE

    3oose an appropriate e%perimental !esi#n

    :relativel" simple !esi#n an! anal"sis meto!s are

    almost al)a"s &est; tat )ill allo) "o$r e%perimental

    ?$estions to &e ans)ere! once te !ata is collecte!

    an! anal"*e!5 (eepin# in min! tra!eoffs &et)eenstatistical po)er an! economic efficienc"' t tis

    point in time it is #enerall" $sef$l to sim$late te

    st$!" &" #eneratin# an! anal"*in# artificial !ata to

    ins$re tat e%perimental ?$estions can &e ans)ere!

    as a res$lt of con!$ctin# "o$r e%periment

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    P7NNING DOE

    Perform te e%periment :collect !ata;pa"in# partic$lar attention s$c tin#s as

    ran!omi*ation an! meas$rement s"stem

    acc$rac"5 )ile maintainin# as $niform ane%perimental environment as possi&le'

    o) te !ata are to &e collecte! is a critical

    sta#e in DOE

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    P7NNING DOE

    nal"*e te !ata $sin# te appropriatestatistical mo!el ins$rin# tat attention is

    pai! to cec(in# te mo!el acc$rac" &"

    vali!atin# $n!erl"in# ass$mptionsassociate! )it te mo!el' e li&eral in te

    $tili*ation of all tools5 incl$!in# #rapical

    tecni?$es5 availa&le in te statisticalsoft)are pac(a#e to ins$re tat a ma%im$m

    amo$nt of information is #enerate!

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    P7NNING DOE

    ase! on te res$lts of te anal"sis5 !ra)concl$sionsCinferences a&o$t te res$lts5

    interpret te p"sical meanin# of tese

    res$lts5 !etermine te practical si#nificanceof te fin!in#s5 an! ma(e recommen!ations

    for a co$rse of action incl$!in# f$rter

    e%periments

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    2B

    SIMP7E 3OMPRTIE EXPERIMENTS

    Sin#le Mean "potesis Test

    Difference in Means "potesis Test )it

    E?$al ariances

    Difference in Means "potesis Test )itne?$al ariances

    Difference in ariances "potesis Test

    Paire! Difference in Mean "potesis Test

    One a" nal"sis of ariance

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    3RITI37 ISSES SSO3ITED IT

    SIMP7E 3OMPRTIE EXPERIMENTS

    o) 7ar#e a Sample So$l! e Ta(eH

    " Does te Sample Si*e Matter

    n")a"H

    at in! of Protection Do e ave

    ssociate! )it Re

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    Sin#le Mean "potesis Test

    fter a pro!$ction r$n of 12 o*' &ottles5concern is e%presse! a&o$t te possi&ilit" tat

    te avera#e fill is too lo)'

    o4 J 12

    a4 KL 12

    level of si#nificance J J 'B0 sample si*e J @

    SPE3 FOR TE MEN4 12 '1

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    Sin#le Mean "potesis Test

    Sample mean J 11'@

    Sample stan!ar! !eviation J B'10

    Sample si*e J @

    3omp$te! t statistic J A2'B PAal$e J B'B>B0162

    3ON37SION4 Since PAal$e L 'B05 "o$

    fail to re

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    Sin#le Mean "potesis Test Po)er 3$rve

    Po)er 3$rvealpa J B'B05 si#ma J B'10

    Tr$e Mean

    Po)er

    11'> 11'@ 12 12'1 12'2B

    B'2

    B'/

    B'6

    B'>

    1

    Si l M i T P

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    Sin#le Mean "potesis Test Po)er

    3$rve A Different Sample Si*es

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    DIFFEREN3E IN MENS A E7

    RIN3ES

    o4 1= 2

    a4 1 2

    level of si#nificance J J 'B0

    sample si*es &ot J 10

    ss$mption4 1J 2

    Sample means J 11'> an! 12'1

    Sample stan!ar! !eviations J B'1 an! B'2

    Sample si*es J 10 an! 10

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    DIFFEREN3E IN MENS A E7 RIN3ES

    3an "o$ !etect tis !ifferenceH

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    DIFFEREN3E IN MENS A E7

    RIN3ES

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    DIFFEREN3E IN MENS A $nE7

    RIN3ES

    Same as te ,E?$al ariance- case e%cept

    te variances are not ass$me! e?$al'

    o) !o "o$ (no) if it is reasona&le to

    ass$me tat variances are e?$al OR

    $ne?$alH

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    +B

    DIFFEREN3E IN RIN3E

    8POTESIS TEST

    Same e%ample as Difference in Mean4

    Sample stan!ar! !eviations J B'1 an! B'2

    Sample si*es J 10 an! 10

    N$ll "potesis4 ratio of variances J 1'B

    lternative4 not e?$al

    3omp$te! F statistic J B'20

    PAal$e J B'B1/BB=1

    Re

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    DIFFEREN3E IN RIN3E

    8POTESIS TEST

    3an "o$ !etect tis !ifferenceH

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    DIFFEREN3E IN RIN3E

    8POTESIS TEST APOER 3RE

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    PIRED DIFFEREN3E IN MENS

    8POTESIS TEST

    T)o !ifferent inspectors eac meas$re 1Bparts on te same piece of test e?$ipment'

    N$ll "potesis4 DIFFEREN3E IN MENS

    J B'B lternative4 not e?$al

    3omp$te! t statistic J A1'22=B2

    PAal$e J B'20B@//

    Do not re

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    PIRED DIFFEREN3E IN MENS

    8POTESIS TEST A POER 3RE

    Po)er 3$rve

    alpa J B'B05 si#ma J +'>66

    Difference in Means

    Po)er

    A0 A/ A+ A2 A1 B 1 2 + / 0

    B

    B'2

    B'/

    B'6

    B'>

    1

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    +0

    ONE 8 N78SIS OF RIN3E

    se! to test "potesis tat te means of

    several pop$lations are e?$al'

    E%ample4 Pro!$ction line as = fill nee!les an!"o$ )is to assess )eter or not te avera#e

    fill is te same for all = nee!les'

    E%periment4 sample 2B fills from eac of te @nee!les an! test at 0 level of si#n'

    o4 1J 2 =3= 4 = 5 =6= 7

    RES7TS4 N78SIS OF RIN3E

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    RES7TS4 N78SIS OF RIN3E

    T7E

    Analysis of Variance

    ---------------------------------------------------------------------------

    Source Sum of Squares Df Mean Square F-Ratio P-Val

    ---------------------------------------------------------------------------

    Between groups 1.11! " .1#$$"% 1#."" .

    it'in groups 1.$(1( 1$$ .!#)#$(---------------------------------------------------------------------------

    *otal +,orr. ).%($" 1$!

    SIN3E NEED7E MENS RE NOT 77

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    SIN3E NEED7E MENS RE NOT 77

    E75 I3 ONES RE DIFFERENTH

    M$ltiple Ran#e Tests for = Nee!lesMet'o/ !0. percent SD

    ,ol2) ,ount Mean 3omogeneous 4roups

    --------------------------------------------------------------------------------

    5( ) 11.(#" 6

    5) ) 11.!#11 651 ) 11.!#)( 6

    5" ) 11.!#($ 6

    5$ ) 11.!!01 6

    50 ) 11.!!0$ 6

    5% ) 1).11 6

    IS7 3OMPRISON OF =

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    +>

    IS7 3OMPRISON OF =

    NEED7ES

    N1

    N2

    N+

    N/

    N0

    N6

    N=

    o%Aan!AGis(er Plot

    11'0 11'= 11'@ 12'1 12'+

    3olQ1

    3olQ2

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    +@

    F3TORI7 :2(; DESIGNS

    E%periments involvin# several factors : ( J

    of factors; )ere it is necessar" to st$!"

    te

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    F3TORI7 :2(; DESIGNS

    Factors are ass$me! to &e fi%e! :fi%e!effects mo!el;

    Desi#ns are completel" ran!omi*e!

    :e%perimental trials are r$n in a ran!omor!er5 etc';

    Te $s$al normalit" ass$mptions are

    satisfie!'

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    F3TORI7 :2(; DESIGNS

    Partic$larl" $sef$l in te earl" sta#es ofe%perimental )or( )en "o$ are li(el" to

    ave man" factors &ein# investi#ate! an!

    "o$ )ant to minimi*e te n$m&er oftreatment com&inations :sample si*e; &$t5 at

    te same time5 st$!" all ( factors in a

    complete factorial arran#ement :te

    e%periment collects !ata at all possi&le

    com&inations of factor levels;'

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    F3TORI7 :2(; DESIGNS

    s ( #ets lar#e5 te sample si*e )illincrease e%ponentiall"' If e%periment is

    replicate!5 te r$ns a#ain increases'

    k # of runs2 4

    3 8

    4 16

    5 32

    6 64

    7 128

    8 256

    9 512

    10 1024

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    /+

    F3TORI7 :2(; DESIGNS :( J 2;

    T)o factors set at t)o levels :normall"

    referre! to as lo) an! i#; )o$l! res$lt inte follo)in# !esi#n )ere eac level of

    factor is paire! )it eac level of factor

    '

    RUN Factor A Factor B RESPNSE RUN Factor A Factor B RESPNSE

    1 !o" !o" #1 1 $1 $1 #1

    2 %&'% !o" #2 2 (1 $1 #2

    3 !o" %&'% #3 3 $1 (1 #3

    4 %&'% %&'% #4 4 (1 (1 #4

    )*n*ra!&+*, S*tt&n s rt%o ona! S*tt&n s

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    F3TORI7 :2(; DESIGNS :( J 2;

    Estimatin# main effects associate! )it

    can#in# te level of eac factor from lo)

    to i#' Tis is te estimate! effect on te

    response varia&le associate! )it can#in#

    factor or from teir lo) to i# val$es'

    2

    ;:

    2

    ;: +1/2 yyyyEffectAFactor +

    +

    =

    2

    ;:

    2

    ;: 21/+ yyyyEffectBFactor +

    +

    =

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    F3TORI7 :2(; DESIGNS :( J 2;4

    GRPI37 OTPT Neiter factor nor Factor ave an effect

    on te response varia&le'

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    F3TORI7 :2(; DESIGNS :( J 2;4

    GRPI37 OTPT

    Factor as an effect on te response

    varia&le5 &$t Factor !oes not'

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    /=

    F3TORI7 :2(; DESIGNS :( J 2;4

    GRPI37 OTPT

    Factor an! Factor ave an effect on te

    response varia&le'

    F3TORI7 :2(; DESIGNS :( J 2;4

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    />

    F3TORI7 :2 ; DESIGNS :( 2;4

    GRPI37 OTPT

    Factor as an effect on te response varia&le5 &$t onl" iffactor is set at te ,i#- level' Tis is called

    interactionan! it &asicall" means tat te effect one factor

    as on a response is !epen!ent on te level "o$ set oter

    factors at' Interactions can &e ma

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    /@

    EXMP7E4

    F3TORI7 :2(; DESIGNS :( J 2;

    micro&iolo#ist is intereste! in te effect

    of t)o !ifferent c$lt$re me!i$ms me!i$m 1

    :lo); an! me!i$m 2 :i#; an! t)o!ifferent times 1B o$rs :lo); an! 2B o$rs

    :i#; on te #ro)t rate of a partic$lar

    3F $#s'

    EXMP7E4

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    0B

    EXMP7E4

    F3TORI7 :2(; DESIGNS :( J 2;

    Since t)o factors are of interest5 ( J25 an!)e )o$l! nee! te follo)in# fo$r r$ns

    res$ltin# in

    RUN -*,&u. /&.* )ro"t% Rat*

    1 !o" !o" 17

    2 %&'% !o" 15

    3 !o" %&'% 38

    4 %&'% %&'% 39

    )*n*ra!&+*, S*tt&n's

    EXMP7E4

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    01

    EXMP7E4

    F3TORI7 :2(; DESIGNS :( J 2;

    Estimates for te me!i$m an! timeeffects are

    Me!i$m effect J :10+@;C2 9 :1= +>;C2 J AB'0

    Time effect J :+>+@;C2 9 :1= 10;C2 J22'0

    EXMP7E4

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    02

    EXMP7E4

    F3TORI7 :2(; DESIGNS :( J 2;

    EXMP7E4

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    0+

    EXMP7E4

    F3TORI7 :2(; DESIGNS :( J 2;

    statistical anal"sis $sin# te appropriatestatistical mo!el )o$l! res$lt in te

    follo)in# information' Factor :me!i$m;

    an! Factor :time;*ype 777 Sums of Squares

    ------------------------------------------------------------------------------------

    Source Sum of Squares Df Mean Square F-Ratio P-Value

    ------------------------------------------------------------------------------------

    FA,*8R A .)0 1 .)0 .11 .(!0)

    FA,*8R B 0".)0 1 0".)0 ))0. .%)%

    Resiual ).)0 1 ).)0------------------------------------------------------------------------------------

    *otal +correcte 0#.(0 $

    All F-ratios are 9ase on t'e resiual mean square error.

    EXMP7E4

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    0/

    EXMP7E4

    3ON37SIONS

    In statistical lan#$a#e5 one )o$l! concl$!etat factor :me!i$m; is not statisticall"

    si#nificant at a 0 level of si#nificance

    since te pAval$e is #reater tan 0 :B'B0;5

    &$t factor :time; is statisticall" si#nificant

    at a 0 level of si#nificance since tis pA

    val$e is less tan 0'

    EXMP7E4

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    00

    EXMP7E4

    3ON37SIONS

    In la"man terms5 tis means tat )e aveno evi!ence tat )o$l! allo) $s to

    concl$!e tat te me!i$m $se! as an effect

    on te #ro)t rate5 alto$# it ma" )ell

    ave an effect :o$r concl$sion )as

    incorrect;'

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    06

    EXMP7E4

    3ON37SIONS !!itionall"5 )e ave evi!ence tat )o$l!

    allo) $s to concl$!e tat time !oes ave an

    effect on te #ro)t rate5 alto$# it ma")ell not ave an effect :o$r concl$sion )as

    incorrect;'

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    0=

    EXMP7E4

    3ON37SIONS

    In #eneral )e control te li(elioo! of

    reacin# tese incorrect concl$sions &" te

    selection of te level of si#nificance for tetest an! te amo$nt of !ata collecte!

    :sample si*e;'

    2( DESIGNS :( L 2;

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    0>

    2(DESIGNS :( L 2;

    s te n$m&er of factors increase5 te

    n$m&er of r$ns nee!e! to complete a

    complete factorial e%periment )ill increase

    !ramaticall"' Te follo)in# 2( !esi#n

    la"o$t !epict te n$m&er of r$ns nee!e! forval$es of ( from 2 to 0' For e%ample5 )en

    ( J 05 it )ill ta(e 20 J +2 e%perimental r$ns

    for te complete factorial e%periment'

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    0@

    Interactions for 2( Desi#ns :( J +;

    Interactions &et)een vario$s factors can&e estimate! for !ifferent !esi#ns a&ove

    &" m$ltipl"in# te appropriate col$mns

    to#eter an! ten s$&tractin# te avera#eresponse for te lo)s from te avera#e

    response for te i#s'

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    6B

    Interactions for 2( Desi#ns :( J +;

    a b c ab ac bc abc

    $1 $1 $1 1 1 1 $1

    (1 $1 $1 $1 $1 1 1

    $1 (1 $1 $1 1 $1 1

    (1 (1 $1 1 $1 $1 $1

    $1 $1 (0 1 $1 $1 1

    (1 $1 (1 $1 1 $1 $1$1 (1 (1 $1 $1 1 $1

    (1 (1 (1 1 1 1 1

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    2(DESIGNS :( L 2;

    Once te effect for all factors an!

    interactions are !etermine!5 "o$ are a&le to

    !evelop a pre!iction mo!el to estimate teresponse for specific val$es of te factors'

    In #eneral5 )e )ill !o tis )it statistical

    soft)are5 &$t for tese !esi#ns5 "o$ can !oit &" an! calc$lations if "o$ )is'

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    2(DESIGNS :( L 2;

    For e%ample5 if tere are no si#nificant interactions

    present5 "o$ can estimate a response &" te

    follo)in# form$la' :for ?$antitative factors onl";

    ONE F3TOR EXMP7E

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    6+

    ONE F3TOR EXMP7E

    Plot of Fitte! Mo!el

    RS STD8

    GR2DE

    1B 12 1/ 16 1> 2B

    00

    60

    =0

    >0

    @0

    ONE F3TOR EXMP7E

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    6/

    ONE F3TOR EXMP7E

    Te o$tp$t so)s te res$lts of fittin# a#eneral linear mo!el to !escri&e te

    relationsip &et)een GRDE an! RS

    STD8' Te e?$ation of te fitte! #eneral

    mo!el is

    GRDE J 2@'+ +'1 :RS STD8;

    Te fitte! orto#onal mo!el is

    GRDE J =0 10 :S37ED RS;

    T 7 l S i D i

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    60

    T)o 7evel Screenin# Desi#ns S$ppose tat "o$r &rainstormin# session

    res$lte! in = factors tat vario$s peopletin( ,mi#t- ave an effect on a response' f$ll factorial !esi#n )o$l! re?$ire 2=J12> e%perimental r$ns )ito$t replication'

    Te p$rpose of screenin# !esi#ns is tore!$ce :i!entif"; te n$m&er of factors!o)n to te ,ma

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    66

    Note tat

    n" factor ! effect is no) confo$n!e! )it te a&interaction

    n" factor e effect is no) confo$n!e! )it te ac

    interaction

    etc'

    at is te !e interaction confo$n!e! )itHHHHHHHHa b c d = ab e = ac f = bc g = abc

    $1 $1 $1 1 1 1 $1

    (1 $1 $1 $1 $1 1 1

    $1 (1 $1 $1 1 $1 1

    (1 (1 $1 1 $1 $1 $1

    $1 $1 (0 1 $1 $1 1

    (1 $1 (1 $1 1 $1 $1

    $1 (1 (1 $1 $1 1 $1

    (1 (1 (1 1 1 1 1

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    6=

    Pro&lems tat Interactions 3a$seU

    Interactions 9 If interactions e%ist an! "o$ fail to

    acco$nt for tis5 "o$ ma" reac erroneo$s

    concl$sions' S$ppose tat "o$ plan an

    e%periment )it fo$r r$ns an! tree factors

    res$ltin# in te follo)in# !ata4

    Pro&lems tat Interactions 3a$seU

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    6>

    Pro&lems tat Interactions 3a$seU

    Factor Effect J B

    Factor Effect J B

    In tis e%ample5 if "o$ )ere ass$min# tat

    ,smaller is &etter- ten it appears to ma(e

    no !ifference )ere "o$ set factors an! 'If "o$ )ere to set factor at te lo) val$e

    an! factor at te lo) val$e5 "o$r response

    varia&le )o$l! &e lar#er tan !esire!' In tiscase tere is a factor interaction )it

    factor '

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    6@

    Pro&lems tat Interactions 3a$seU

    Interaction Plot

    F3TOR

    0

    6

    =

    >

    @

    1B

    RESPONSE

    A1 1

    F3TOR A1

    1

    Resol$tion of a Desi#n

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    =B

    #

    Resol$tion III Desi#ns 9 No main effects arealiase! )it an" oter main effect T some :orall; main effects are aliase! )it t)o )a"interactions

    Resol$tion I Desi#ns 9 No main effects arealiase! )it an" oter main effect OR t)o factorinteraction5 T t)o factor interactions ma" &ealiase! )it oter t)o factor interactions

    Resol$tion Desi#ns 9 No main effect OR t)o

    factor interaction is aliase! )it an" oter maineffect or t)o factor interaction5 T t)o factorinteractions are aliase! )it tree factorinteractions'

    i i

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    =1

    3ommon Screenin# Desi#ns

    Fractional Factorial Desi#ns 9 te totaln$m&er of e%perimental r$ns m$st &e a

    po)er of 2 :/5 >5 165 +25 6/5 V;' If "o$

    &elieve first or!er interactions are small

    compare! to main effects5 ten "o$ co$l!

    coose a resol$tion III !esi#n' W$st

    remem&er tat if "o$ ave ma

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    =2

    3ommon Screenin# Desi#ns

    Plac(ettA$rman Desi#ns 9 T)o level5resol$tion III !esi#ns $se! to st$!" $p to

    nA1 factors in n e%perimental r$ns5 )ere

    n is a m$ltiple of / : of r$ns )ill &e /5 >5

    125 165 V;' Since n ma" &e ?$ite lar#e5

    "o$ can st$!" a lar#e n$m&er of factors

    )it mo!eratel" small sample si*es' :n J

    1BB means "o$ can st$!" @@ factors )it1BB r$ns;

    Oter Desi#n Iss$es

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    =+

    Oter Desi#n Iss$es

    Ma" )ant to collect !ata at center points to

    estimate nonAlinear responses

    More tan t)o levels of a factor 9 no

    pro&lem :m$ltiAlevel factorial;

    at !o "o$ !o if "o$ )ant to &$il! a nonA

    linear mo!el to ,optimi*e- te response'

    :it a tar#et5 ma%imi*e5 or minimi*e; 9

    calle! response s$rface mo!elin#

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    =/

    Response S$rface Desi#ns 9 o%Aen(en

    RUN F1 F2 F3 100

    1 10 45 60 11825

    2 30 45 40 8781

    3 20 30 40 8413

    4 10 30 50 9216

    5 20 45 50 9288

    6 30 60 50 8261

    7 20 45 50 9329

    8 30 45 60 10855

    9 20 45 50 9205

    10 20 60 40 8538

    11 10 45 40 9718

    12 30 30 50 11308

    13 20 60 60 10316

    14 10 60 50 12056

    15 20 30 60 10378

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    =0

    Response S$rface Desi#ns 9 o%Aen(en

    Regression coeffs. for Var_3

    ----------------------------------------------------------------------

    constant = 2312.5

    A:Factor_A = 36.575

    B:Factor_B = 200.067C:Factor_C = 3.85

    AA = .0875

    AB = -.81167

    AC = -0.0825

    BB = 0.117222

    BC = -0.311667

    CC = 1.10875

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    Response S$rface Desi#ns 9 o%Aen(en

    3onto$rs of Estimate! Response S$rface

    FactorQ3J6B'B

    FactorQ

    FactorQ1

    arQ+

    @+BB'B

    @0BB'B@=BB'B

    @@BB'B

    1B1BB'B

    1B+BB'B

    1B0BB'B

    1B=BB'B

    1B@BB'B

    111BB'B

    11+BB'B

    110BB'B

    11=BB'B

    1B 1/ 1> 22 26 +B

    +B

    +0

    /B

    /0

    0B

    00

    6B

    37SSROOM EXER3ISE

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    ==

    37SSROOM EXER3ISE

    STDENT INA37SS EXPERIMENT4

    3ollect !ata for e%periment to !eterminefactor settin#s :t)o factors; to it a tar#et

    response :spot on )all;'

    Factor 9 ei#t of sa(er :lo) an! i#;

    Factor 9 location of sa(er :close to

    an! an! close to )all;

    Desi#n e%periment 9 )o$l! s$##est

    several replications

    37SSROOM EXER3ISE

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    =>

    37SSROOM EXER3ISE

    3on!$ct E%periment 9 st$!ent ol!s + foot

    ,pin te tail on te !on(e"- stic( an!attempts to it te tar#et' n o&server )ill

    assist to mar( te it on te tar#et'

    3ollect !ata 9 st$!ents ta(e !ata ome for)ee( an! come &ac( )it )at "o$ )o$l!

    recommen! ND )"'

    8O TE77 TE 37SS O TO P78TE GME TO ,IN-'

    37SSROOM EXER3ISE

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    =@

    37SSROOM EXER3ISE

    37SSROOM EXER3ISE

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    >B

    37SSROOM EXER3ISE

    -ARER

    S/

    ER/A

    PE1S/ BS 2N BS 3R BS 4/ BS -EAN

    S/ANAR

    EA/N

    $2750 $4500 $4750 $5000 $4250 1021

    $12500 $6750 $4625 $4000 $6969 3871

    3000 3250 3875 6250 4094 1484

    4625 11250 12625 14000 10625 4155

    -ARER

    S/

    : ER/A PE ;AS SE / ;A

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    3onto$r Plots for Mean an! St!' Dev'