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Research report Suicidal intent in deliberate self-harm and the risk of suicide: The predictive power of the Suicide Intent Scale Louise Harriss, Keith Hawton T Centre for Suicide Research, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK Received 9 August 2004; received in revised form 2 February 2005; accepted 4 February 2005 Abstract Background: Suicidal intent at the time of deliberate self-harm (DSH) is known to be associated with risk of future suicide in DSH patients. The predictive power of suicidal intent to identify particular individuals who are at high risk of suicide is unclear. Method: Clinical and demographic data on 4156 DSH patients presenting to hospital 1993 and 1997 were analysed. Follow-up information on eventual suicide was available for 2489 patients (mean follow-up 5.2 years). The predictive value of the Beck Suicidal Intent Scale (SIS) was examined using Receiver Operating Characteristic (ROC) plots. Results: Thirty males (2.9%) and 24 females (1.7%) died by suicide. Despite a robust association between suicidal intent and eventual suicide, the positive predictive value (PPV) of the SIS was low (4%). Predicted probabilities of suicide assigned to individual patients were also low, even for those who eventually died by suicide. Limitations: Assessment and follow-up information was not available for all patients. Conclusions: The SIS cannot predict which individual patients will ultimately die by suicide. Nonetheless, information regarding suicidal intent is valuable in the clinical risk assessment and management of DSH patients. D 2005 Elsevier B.V. All rights reserved. Keywords: Attempted suicide; Deliberate self-harm; Suicidal intent; Suicide; Follow-up 1. Introduction The risk of suicide amongst patients who engage in deliberate self-harm (DSH) is considerably higher than the risk within the general population (Owens et al., 2002). Whilst this risk remains elevated for many years after a DSH episode (Hawton and Fagg, 1988; Sakinofsky, 2000; Owens et al., 2002), it is at its greatest during the first 12 months. A recent inves- tigation in the UK found the suicide risk amongst DSH patients during the first year following DSH to be 66 times the population risk (Hawton et al., 2003b). It has therefore been a major concern of researchers and clinicians to establish risk factors for eventual suicide in DSH patients (Sakinofsky, 2000). An extensive range of clinical and demographic charac- 0165-0327/$ - see front matter D 2005 Elsevier B.V. All rights reserved. doi:10.1016/j.jad.2005.02.009 T Corresponding author. Fax: +44 1865 223933. E-mail address: [email protected] (K. Hawton). Journal of Affective Disorders 86 (2005) 225 – 233 www.elsevier.com/locate/jad

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www.elsevier.com/locate/jad

Journal of Affective Disord

Research report

Suicidal intent in deliberate self-harm and the risk of suicide:

The predictive power of the Suicide Intent Scale

Louise Harriss, Keith HawtonT

Centre for Suicide Research, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK

Received 9 August 2004; received in revised form 2 February 2005; accepted 4 February 2005

Abstract

Background: Suicidal intent at the time of deliberate self-harm (DSH) is known to be associated with risk of future suicide in

DSH patients. The predictive power of suicidal intent to identify particular individuals who are at high risk of suicide is unclear.

Method: Clinical and demographic data on 4156 DSH patients presenting to hospital 1993 and 1997 were analysed. Follow-up

information on eventual suicide was available for 2489 patients (mean follow-up 5.2 years). The predictive value of the Beck

Suicidal Intent Scale (SIS) was examined using Receiver Operating Characteristic (ROC) plots.

Results: Thirty males (2.9%) and 24 females (1.7%) died by suicide. Despite a robust association between suicidal intent and

eventual suicide, the positive predictive value (PPV) of the SIS was low (4%). Predicted probabilities of suicide assigned to

individual patients were also low, even for those who eventually died by suicide.

Limitations: Assessment and follow-up information was not available for all patients.

Conclusions: The SIS cannot predict which individual patients will ultimately die by suicide. Nonetheless, information

regarding suicidal intent is valuable in the clinical risk assessment and management of DSH patients.

D 2005 Elsevier B.V. All rights reserved.

Keywords: Attempted suicide; Deliberate self-harm; Suicidal intent; Suicide; Follow-up

1. Introduction

The risk of suicide amongst patients who engage in

deliberate self-harm (DSH) is considerably higher

than the risk within the general population (Owens et

al., 2002). Whilst this risk remains elevated for many

years after a DSH episode (Hawton and Fagg, 1988;

0165-0327/$ - see front matter D 2005 Elsevier B.V. All rights reserved.

doi:10.1016/j.jad.2005.02.009

T Corresponding author. Fax: +44 1865 223933.

E-mail address: [email protected] (K. Hawton).

Sakinofsky, 2000; Owens et al., 2002), it is at its

greatest during the first 12 months. A recent inves-

tigation in the UK found the suicide risk amongst

DSH patients during the first year following DSH to

be 66 times the population risk (Hawton et al.,

2003b).

It has therefore been a major concern of researchers

and clinicians to establish risk factors for eventual

suicide in DSH patients (Sakinofsky, 2000). An

extensive range of clinical and demographic charac-

ers 86 (2005) 225–233

L. Harriss, K. Hawton / Journal of Affective Disorders 86 (2005) 225–233226

teristics of these patients has been shown to have a

strong association with suicide risk: e.g., age, gender,

employment status, living situation, DSH method,

previous DSH (Hawton and Fagg, 1988; Sakinofsky,

2000). In a recent follow-up study of a large sample of

DSH patients in Oxford, UK (Harriss et al., 2005), we

demonstrated that the level of suicidal intent at the

time of DSH–that is, the degree to which the

individual wished to die–is also associated with risk

of subsequent suicide. Patients with high scores on the

Beck Suicide Intent Scale (SIS) (Beck et al., 1974)

were significantly more likely to die by suicide than

patients with low SIS scores. This association was

found to be especially strong within the first year after

an episode, and amongst female patients. We con-

cluded that the measurement of suicidal intent is

valuable in the evaluation of future suicide risk,

particularly when considered in conjunction with

other known risk factors.

Intrinsic to the investigation of such risk factors

for suicide is the question of prediction: is it

possible, in the light of these findings, to identify

particular individuals who are at risk of eventually

dying by suicide? Studies that have endeavoured to

do so have been largely unsuccessful (e.g., Pokorny,

1983, 1993; Goldney and Spence, 1987; Goldstein et

al., 1991; Powell et al., 2000), primarily due to the

low prevalence of suicide even within high-risk

patient groups.

Receiver Operating Characteristic (ROC) curves,

which are most often used to evaluate the efficacy

of diagnostic tests (Zweig and Campbell, 1993), can

be employed to assess the performance of psycho-

logical scales (e.g., Beck et al., 1999). Nimeus et al.

(2002) used this method in their evaluation of the

predictive value of the SIS. Despite having found

significantly higher SIS scores amongst the eventual

suicides (22 of the original sample of 555 DSH

patients), the optimal cut-off score for distinguishing

between suicides and non-suicides yielded a positive

predictive value (PPV) of only 9.7%; that is, less

than 10% of patients predicted to die by suicide

according to their SIS scores were correctly

classified as such. Nevertheless, Nimeus et al. deduced

that the SIS might be ba valuable tool in predicting

suicideQ.Given the widespread use of the SIS within clinical

practice, it is important that its role in evaluating

future suicide risk is clearly established. Using a long-

term monitoring system for DSH that provides a large

patient sample and a substantial follow-up period, we

have investigated the ability of the Beck Suicide

Intent Scale to predict the occurrence of future suicide

in DSH patients.

2. Method

2.1. Study population

Patients were identified through the Oxford Mon-

itoring System for Attempted Suicide (Hawton et al.,

2003a). All individuals who present to the general

hospital in Oxford following an episode of DSH are

identified either through assessment by members of

the hospital psychiatric service, or by scrutiny of

records of presentations to the Accident and Emer-

gency Department. It has been established that this

system produces comprehensive data (Sellar et al.,

1990), and that the findings are comparable with those

from other areas in the UK (e.g., Platt et al., 1988).

The definition of DSH encompasses intentional

self-poisoning or self-injury, irrespective of motiva-

tion (Hawton et al., 2003a). Self-poisoning is defined

as the intentional self-administration of more than the

prescribed dose of any drug, and includes poisoning

with non-ingestible substances, overdoses of

drecreational drugsT, and severe alcohol intoxication

where clinical staff consider such cases to be acts of

deliberate self-harm. Approximately 85% of cases

involve overdoses (Hawton et al., 2003a). Self-injury

is defined as any injury that has been deliberately self-

inflicted.

For all patients assessed by the general hospital

psychiatric service, a clinician completes a stand-

ardised form that records demographic and clinical

information. Since 1st January 1993, the Suicide

Intent Scale (SIS) devised by Beck et al. (1974) has

also been completed at the time of assessment

whenever possible. All assessed DSH patients aged

15 or over, who presented to the general hospital

between 1st January 1993 and 31st December 1997,

and for whom the SIS had been completed on at

least one presentation, were included in the study.

The follow-up period extended until 31st December

2000.

L. Harriss, K. Hawton / Journal of Affective Disorders 86 (2005) 225–233 227

2.2. Suicide Intent Scale

The Beck Suicide Intent Scale (SIS) is a 15-item

interviewer-rated questionnaire designed to assess the

severity of suicidal intention associated with an

episode of DSH (Beck et al., 1974). Each item

scores 0–2, giving a total score range of 0–30. The

questionnaire is divided into two sections: the first

eight items comprise the dcircumstancesT section

(Part 1), and are concerned with the objective

circumstances of the act of DSH. The remaining

seven items form the dself-reportT section (Part 2),

and are based on the patient’s own reconstruction of

his/her feelings and thoughts at the time of the act.

Scores for each of these sections were considered

separately in the analysis, as well as the total SIS

score of both sections combined.

We have investigated the predictive value of

suicidal intent alongside a range of demographic and

clinical variables recorded during assessment: age,

marital status, employment status, drug misuse,

alcohol misuse (defined as chronic alcoholism with

physical symptoms, alcohol dependence, or excessive

drinking), current and previous psychiatric treatment,

lonely living conditions (living alone, in an institution,

in lodgings or in a hostel), previous DSH (irrespective

of whether or not this resulted in a general hospital

referral), and method of DSH.

2.3. Suicide

Deaths from suicide that occurred up to 31st

December 2000 were identified for patients who

presented between 1st January 1993 and 31st Decem-

ber 1997, through the submission of demographic

information (name, gender, and date of birth) to the

Office of National Statistics for England and Wales,

the Central Services Agency in Northern Ireland, and

the General Register Office for Scotland. Tracing

revealed whether a patient was alive or deceased as of

31st December 2000. Patients who could not be traced

were excluded from the analyses. All deaths that

received a coroner’s verdict of dsuicideT (ICD-9 code

E950–E959), dundetermined causeT (E980–E989), ordaccidental poisoningT (E850–E869) were combined

to form the suicide category for the purposes of this

study. It has been shown that the overall mortality

from suicide will be underestimated if the dsuicideT

verdict alone is used (Charlton et al., 1992). Fur-

thermore, amongst DSH patients, the risk of death by

accidental poisoning is similar to the risk of death by

suicide or undetermined cause (Hawton et al.,

submitted for publication). Examination of individual

cases of accidental poisoning that occurred within the

study sample revealed that such verdicts were highly

likely to be suicide.

2.4. Statistical analyses

Receiver Operating Characteristic (ROC) curves

were employed to examine the data. The ability of the

SIS to distinguish between the suicide and non-suicide

groups was measured by calculating the sensitivity

(proportion of true positives correctly identified) and

specificity (proportion of true negatives correctly

identified) when using each possible score on the

SIS as the cut-off value for group membership. The

ROC plots provide a graphical display of all

sensitivity/specificity pairs for every possible cut-off

value on the scale.

Choosing an doptimumT cut-off value of a test is

necessarily subjective, and dependent on a range of

factors such as the relative cost (e.g., severity of

outcome, financial cost) of errors (false positives and

false negatives), and the prevalence of the disease that

the test is designed to predict. For example, a cut-off

value that produces a particular true- or false-positive

rate may be optimal under certain circumstances; one

that is based on the change in the post-test odds of the

outcome may be more appropriate in others (Rutter

and Miglioretti, 2003). Following Beck et al. (1999)

and Nimeus et al. (2002), the optimal cut-off value for

the purposes of this study was considered to be the

one that maximised the correct classification of both

suicides and non-suicides—i.e., maximised the sum of

sensitivity and specificity.

Whereas sensitivity and specificity measure the

ability of the SIS to distinguish between groups, it is

the predictive value at a particular cut-off point that

gives the probability of a correct prediction of suicide

or non-suicide (Altman and Bland, 1994a). The

positive predictive value (PPV: the fraction of positive

results that are correct) at each point on the SIS was

also calculated.

Backward stepwise Cox regression analysis was

used to investigate risk factors for eventual suicide.

0.50

0.75

1.00

10

0

sitiv

ity

(a) Male SIS total scores

L. Harriss, K. Hawton / Journal of Affective Disorders 86 (2005) 225–233228

Binary logistic regression analysis was used to

identify probability of and prediction of suicide group

membership.

The analyses were conducted using the Statistical

Package for the Social Sciences (SPSS Inc., 2003),

and Stata 7 (StataCorp, 2001).

0.00

0.25

0.50

0.75

1.00

0.00 0.25 0.50 0.75 1.00

1 - Specificity

14

0

10

20

0.00

0.25

0.00 0.25 0.50 0.75 1.00

1 - Specificity

20

Sen

Sens

itivi

ty

(b) Female SIS total scores

Fig. 1. Receiver Operating Characteristic (ROC) plots of the

relationship between total Suicide Intent Scale (SIS) scores and

eventual suicide, for (a) male and (b) female DSH patients.

3. Results

Between 1st January 1993 and 31st December

1997, a total of 4156 persons (1783 males and 2373

females) presented following 6316 episodes of delib-

erate self-harm. Psychosocial assessment occurred for

4560 (72.2%) of these episodes. A SIS score was

available for 3339 (73.2%) of the assessed episodes,

by 2719 persons (1136 males, 1583 females). Follow-

up information was available for 2489 of these

patients (1049 males, 1440 females), who comprised

the final sample of patients that were included in the

analysis (mean follow-up time of 5.2 years, range 2

days to 8 years). Thirty males (2.9%) and 24 females

(1.7%) in this sample died by suicide.

To assess whether they comprised a representative

sample, these 2489 patients were compared with 1667

patients that were omitted from the analysis. No

significant differences in gender or age were found

between the two groups. The only notable difference

between the two patient groups was in method of

DSH. Patients included in the study were significantly

less likely to have used self-cutting than the patients

who could not be included (3.7% vs. 11.5%, v2=94.8,

p b0.001).

ROC curves for total SIS scores for male and

female patients are presented in Fig. 1.

Scores are read from the top right-hand corner of

the plot (SIS score of 0) to the bottom left (SIS score

of 30). The area under the ROC curve reflects the

overall precision of the scale; its value indicates the

probability that a randomly selected patient who died

by suicide had higher SIS score than a randomly

selected patient who did not die by suicide. A test with

perfect discrimination has a ROC plot that passes

through the upper left-hand corner (sensitivity=1,

1�specificity=0); a test that does not discriminate

between groups produces a 45-8 diagonal line.Although the SIS did discriminate between the

male suicide and non-suicide patient groups (area

under the ROC curve=0.63, p =0.02), its performance

as a predictor was relatively weak. Selecting a cut-off

value on the SIS that minimised error (i.e., maximised

the sum of sensitivity and specificity) gave a value of

10, with a sensitivity of 76.7% and specificity of

48.8%. However, this yields a positive predictive

value (PPV) of only 4.2%, correctly identifying 23 of

the 30 male suicides (true positives), but also

mistakenly identifying as suicides 522 of the 1019

non-suicides (false positives). The maximum PPV of

8.0% occurred at a cut-off value of 24, at which point

only 2 of the suicides were correctly identified.

The SIS performed better overall as a discriminator

between female suicides and non-suicides, as evi-

denced by the area under the female total SIS score

ROC curve (area=0.75, p b0.001). The optimal cut-

off value minimising error occurs at a score of 14,

with a sensitivity 66.7% and specificity 75.3%,

correctly identifying 16 of the 24 suicides. However,

(b) Male Part 2 SIS scores

(a) Male Part 1 SIS scores

0.00

0.25

0.50

0.75

1.00

0.00 0.25 0.50 0.75 1.00

1 - Specificity

5

0

10

Sens

itivi

ty

0.00

0.25

0.50

0.75

1.00

0.00 0.25 0.50 0.75 1.00

1 - Specificity

10

0

5

Sens

itivi

ty

Fig. 2. Receiver Operating Characteristic (ROC) plots of the

relationship between Suicide Intent Scale (SIS) (a) Part 1 and (b)

Part 2 scores and eventual suicide, for male DSH patients. 0.00

0.25

0.50

0.75

1.00

0.00 0.25 0.50 0.75 1.00

1 - Specificity

6

7

0

10

5

Sens

itivi

ty

0.00

0.25

0.50

0.75

1.00

0.00 0.25 0.50 0.75 1.00

1 - Specificity

12

0

5

10

Sens

itivi

ty

(a) Female Part 1 SIS scores

(b) Female Part 2 SIS scores

Fig. 3. Receiver Operating Characteristic (ROC) plots of the

relationship between Suicide Intent Scale (SIS) (a) Part 1 and (b

Part 2 scores and eventual suicide, for female DSH patients.

L. Harriss, K. Hawton / Journal of Affective Disorders 86 (2005) 225–233 229

the PPV was again low at only 4%. The maximum

PPV of 67% occurred at a cut-off value of 29—

however, at this point sensitivity is extremely low

(8.3%) and only 2 of the female suicides are correctly

identified.

The performance of each of the two sections of the

SIS was also examined. ROC plots for Part 1 and Part

2 scores in male patients are presented in Fig. 2. Part

1, the dcircumstancesT section, performed slightly

better amongst male patients (area=0.63, p =0.02)

than Part 2, the dself-reportT section (area=0.61,

p =0.04), though neither part was individually more

proficient at discriminating between male suicides and

non-suicides than the total SIS score. Once again, the

optimal cut-off points that minimise error–a score of 5

for Part 1; 10 for Part 2–yielded low PPVs (4% and

6%, respectively).

The superior overall performance of Part 1 of the

SIS amongst females is clearly indicated by the ROC

plots for the two sections of the scale (Fig. 3). The

area under the ROC plot for Part 1 (area=0.76,

pb0.001) was similar to the plot generated by the

female total scores; the ROC plot for Part 2 generated

a slightly smaller area (area=0.72, pb0.001). The

equally optimal cut-off points for Part 1 were 6

(sensitivity 75.0%, specificity 72.6%, PPV 4%) and 7

(sensitivity 66.7%, specificity 80.9%, PPV 6%),

which correctly identify 18 and 16 of the 24 female

suicides, respectively. The optimal cut-off value for

Part 2 is high at 12; this level has a PPV of 11%, and

would correctly identify 9 suicides.

Total SIS scores were transformed into a binary

variable of dhighT and dlowT SIS scores based upon

cut-off points established during the ROC analysis.

)

Table 2

Logistic regression analysis estimated probabilities for outcome of

suicide, for male and female DSH patients

Probability of suicide Non-suicides, N (%) Suicides, N (%)

Males

b1% 259 (27) 2 (7)

1–5% 513 (52) 13 (45)

N5% 208 (21) 14 (48)

Females

b1% 981 (71) 4 (17)

1–5% 331 (24) 14 (58)

N5% 70 (5) 6 (25)

L. Harriss, K. Hawton / Journal of Affective Disorders 86 (2005) 225–233230

Univariate regression analysis demonstrated a strong

association between high SIS scores and eventual

suicide (for males, hazard ratio (HR)=3.14, 95% CI

1.3–7.3, p b0.01; for females, HR=6.02, 95% CI 2.5–

14.6, p b0.001). When examined in conjunction with

other known risk factors for suicide (age, marital

status, employment status, lonely living situation,

current and previous psychiatric treatment, method of

DSH, previous DSH, misuse of alcohol, misuse of

drugs), high SIS scores remained a significant risk

factor for eventual suicide (Table 1).

Amongst male patients, alcohol misuse (HR=3.92,

95% CI 1.6–9.3; p b0.01) and a total SIS score of 10

or above (HR=3.39, 95% CI 1.4–8.5; p b0.01) were

independently associated with suicide. Amongst

female patients, suicide was associated with a total

SIS score of 14 or above (HR=5.80, 95% CI 2.2–

15.3; p b0.001), previous psychiatric treatment

(HR=5.01, 95% CI 1.4–17.6; p b0.02), and being

over 35 years of age (HR=2.44, 95% CI 1.0–6.0;

p =0.05).

Logistic regression analysis was used to estimate

the probability of eventual suicide for each patient. As

expected, the logistic regression models for male and

female patients employed the same risk factors as

included in the Cox regression, with odds ratios

comparable to the above hazard ratios. The logistic

regression analysis assigned a probability of eventual

suicide to each patient based upon the presence or

absence of these risk factors (Table 2).

Almost half the male suicides (N =14, 48%) were

estimated to have a probability of eventual suicide of

Table 1

Multivariate Cox regression analysis for factors associated with

suicide, for male and female DSH patients

Males (N =908) Females (N =1264)

HR 95% CI p HR 95% CI p

High SIS score

Yes 3.39 1.4–8.5 b0.01 5.80 2.2–15.3 b0.001

Alcohol misuse

Yes 3.92 1.6–9.3 b0.01

Previous

psychiatric

treatment

Yes 5.01 1.4–17.6 b0.02

Age

35+ years 2.44 1.0–6.0 0.05

SIS: Suicide Intent Scale.

more than 5% (highest probability 7.5%), as were

21% of the male non-suicides. The remaining 15

suicides were predicted to have a less than 5%

likelihood of suicide. Amongst female patients, 75%

(N =28) of the suicides were predicted to have a likely

outcome of suicide of less than 5%. The highest

probability of eventual suicide, 11%, was assigned to

6 (25%) of the female suicides, and 5% of the female

non-suicides. Almost one fifth (17%) of the female

suicides were assigned a probability of eventual

suicide of less than 1%.

Based upon these probabilities, the logistic regres-

sion analysis assigned each patient to a dsuicideT ordnon-suicideT group. As the predicted probabilities of

eventual suicide were consistently low, none of the

patients were assigned to the dsuicideT group—i.e., the

logistic regression models were not able to identify

any of the patients who eventually died by suicide.

4. Discussion

In this study of the predictive power of the Beck

Suicide Intent Scale, ROC curves for the SIS scores of

DSH patients confirmed the relationship between

suicidal intent at the time of DSH and future suicide.

Maximising the sensitivity and specificity of the SIS

produced cut-off values for dhighT and dlowT intent

scores that successfully differentiated between even-

tual suicides and non-suicides in both male and female

patients, although the performance of the SIS amongst

male patients was relatively weak. The ROC curve for

scores on the dcircumstancesT section of the SIS was

particularly efficient at distinguishing between female

suicides and non-suicides. These findings support the

L. Harriss, K. Hawton / Journal of Affective Disorders 86 (2005) 225–233 231

results of our previous study, which demonstrated that

the relationship between SIS scores and suicide was

strongest amongst female DSH patients, and for the

dcircumstancesT section of the SIS (Harriss et al.,

2005).

However, despite the relatively strong sensitivity

and specificity of the SIS, especially amongst female

patients, the positive predictive value (PPV) of the

scale remained low; that is, only a small percentage of

those patients identified by their SIS scores as being

likely to die by suicide were correctly identified as

such. Whilst the cut-off values produced by the ROC

analysis correctly identified over two-thirds of the

suicides, the majority of patients that were predicted

to die by suicide (96%) in fact did not.

In their study of 555 DSH patients, of whom 22

(4.0%) later died by suicide, Nimeus et al. (2002)

obtained an optimum cut-off score of 19, with

sensitivity of 59.1% and specificity of 77.3%. The

overall diagnostic performance of the SIS in the

present study was comparable for male patients, and

superior amongst female patients, as evidenced by

higher sensitivity and specificity percentages. Due to

the lower suicide rate amongst our DSH patient group

(2.9% in males, 1.7% in females), the PPV of the SIS

in the present study (4%) was even lower than that

reported by Nimeus et al. (9.7%).

Nimeus et al. obtained a relatively high PPV

(22.5%) in patients over 55 years of age, for whom

a suicide rate of 11.4% (10/88) was reported.

Although the suicide rates in older patients in our

study were higher than the overall rates (3.7% in

males over 35 years of age, 2.9% in females over 35),

they were not sufficiently different to produce any

notable increases in the positive predictive value of

the SIS. These findings clearly demonstrate that if the

prevalence of the outcome under investigation is low,

the predictive value of the measure will be low even if

the sensitivity and specificity are high (Altman and

Bland, 1994a; Pokorny, 1993). They also illustrate the

diversity in suicide rates following DSH that have

been found amongst different countries; rates in the

UK have been reported to be considerably lower than

rates found elsewhere (Owens et al., 2002), especially

other Northern European countries (Nordentoft et al.,

1993).

There are some limitations to this study. It was not

possible to include all the DSH patients who

presented to the general hospital during the study

period, as some did not receive an assessment, and the

SIS was not completed for all of those who were

assessed. Whilst complete follow-up information was

obtainable for a large proportion of the sample, for

some patients this information was not available or

covered a limited time period. The only difference

found between the patients included in the analyses

and those omitted was in method of DSH-omitted

patients were more likely to have engaged in self-

cutting. As self-cutting is likely to be associated with

lower suicidal intent scores (Harriss et al., 2005),

inclusion of these patients (had SIS scores been

available) may have led to a lower average SIS score

across the sample. Whilst this may have affected the

optimal cut-off points established in the ROC

analysis, it would not have affected the overall

conclusions regarding the performance of the SIS.

In order to allow a sufficient follow-up period,

suicides were only identified in patients who pre-

sented during the first 5 years of the study period. The

patients who were categorised as having died from

suicide included those whose deaths were officially

recorded as suicides, open verdicts, or accidental

poisonings. This approach, which has been employed

in previous studies (Charlton et al., 1992; Hawton et

al., 1998), ensures as complete an identification of

suicides as possible. Although few deaths will be

misidentified through this procedure, some suicides

may be missed due to misclassification under other

categories.

For the purposes of this study, the optimum cut-off

value was chosen to be the one that minimised error,

or maximised the sum of sensitivity and specificity.

Whilst this is the simplest approach, it may not always

be the most appropriate, as the selection of a decision

threshold is dependent on the specific aims under

consideration (Altman and Bland, 1994b). For exam-

ple, if the aim is to identify a high-risk group for

research purposes, it will be most desirable to select a

cut-off value that minimises the number of false

positives. Conversely, a prevention strategy might

require that as many true positives are identified as

possible (high sensitivity), regardless of the many of

false positives that may also be captured (low

specificity). Whichever approach was selected for

the patient group in this study, the predictive value of

the SIS remained low. Maximising the predictive

L. Harriss, K. Hawton / Journal of Affective Disorders 86 (2005) 225–233232

value of the SIS yielded an extremely low true

positive rate.

The results of the regression analysis corroborate

the findings of a number of other studies (e.g.,

Pokorny, 1983, 1993; Goldney and Spence, 1987;

Powell et al., 2000), that it is not possible use patient

information–even information about factors that have

been shown to be strongly related to suicide, such as

suicidal intent–to predict accurately which individual

patients will die by suicide. The predicted probabil-

ities of eventual suicide are low, even amongst the

suicide patient group. These findings highlight the

dangers of attempting to use a bchecklistQ approach

for identifying at-risk patients—measures such as the

SIS cannot be used as straightforward predictive tools

for determining treatment decisions.

However, the utility of clinical scales in the

treatment and management of patients is not depend-

ent on their predictive value alone (Zweig and

Campbell, 1993). The process of clinical risk assess-

ment is not the same as the process of prediction—this

distinction is vital for appropriate interpretation of the

findings of studies such as this. Clinical risk assess-

ment is a complex decision-making process that takes

into account a multitude of factors, and is consid-

erably more sophisticated than the statistical techni-

ques that have been employed by researchers to

predict suicide. The clinician can be informed in his or

her assessment by considering a range of character-

istics of the individual patient, particularly those that

are known to be strongly associated with eventual

suicide. The robustness of high SIS scores as a

significant factor in the regression models confirms

that patients with high SIS scores at the time of DSH

are at increased risk of dying by suicide, and thus

supports the use of information about suicidal intent

as part of a clinical suicide risk assessment.

Acknowledgements

The authors thank the staff of the Office of

National Statistics for England and Wales, the

General Register Office for Scotland, and the Central

Services Agency in Northern Ireland for their

assistance with this project. Staff at the Department

of Psychological Medicine at the John Radcliffe

Hospital in Oxford, and Elizabeth Bale and Alison

Bond assisted with the collection of patient informa-

tion that was used in this study. We also thank

Daniel Zahl, who compiled the mortality follow-up

information. The Oxford Monitoring System is

funded by the Department of Health. The mortality

follow-up study was funded by a grant from the

National Health Science Executive for England.

Keith Hawton is also supported by Oxfordshire

Mental Healthcare trust. There is no conflict of

interest.

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