lecture 1:introduction to biology 202 - amazon s3

BIOL 202 - T. Western 2005 1

Welcome to BASIC GENETICS (Biology 202)

 Extra seating is available upstairs in Leacock 219 (Course video is

available on WebCT )


Biology 202 professors:

Paul LASKO

Molecular genetics

Mario CHEVRETTE

Molecular genetics and human genetics

Daniel SCHOEN

Classical and population genetics


Lecture 1:Introduction to Biology 202

 Course information & organization

 Course Overview

 Overview of Genetics – past & present


Introduction to Biology 202 Lectures in Leacock 132

MWF 8:30-9:25 am Simulcast to Leacock 219 MWF 8:30-9:25 am*

Copies of slides video and audio recordings of the lectures will be

available on WebCT* (http://webCT.mcgill.ca)


PLEASE READ the Biology 202 Course Syllabus

(on line on WEBCT)


Questions (who to ask): Course material: Ask your professor after class OR

by E-mail:

Daniel Schoen [email protected] Paul Lasko [email protected] Mario Chevrette [email protected]

Conference and Problem Set Questions: Please contact the TA’s: E-mail addresses on WebCT page soon.....

To see exams: [email protected] (room W3/25A Stewart Biology)


Technical Glitches

 Problems with the WebCT page (apart from course videos): [email protected]

 Problems with lecture recordings: [email protected] or [email protected]


Conferences:  1.5 h/week – optional but highly

recommended  Review sample problems with TAs

 Scheduled times: Mon-Fri afternoons   Begin on Monday afternoon, week of 18 Jan.   For time & room details, see WebCT.

 You may attend any session & you may switch days/times from one week to the next


Required Text: Introduction to Genetic Analysis 9th ed.

(Griffiths, Wessler, Lewontin, et al)

 Available at the McGill bookstore

  Available as an e-book: http://ebooks.bfwpub.com/iga9e.php://

ebooks.bfwpub.com/iga9e.php://ebooks.bfwpub.com/iga9e.php


Other resources:  Also available: MegaManual 9th ed. (provides

solutions for all problems in the text).  Interactive Genetics CD (a step-by-step

approach to problem solving—comes with the MegaManual)

 Web Site for text: http://bcs.whfreeman.com/iga9e has animations, practice tests, interactive exercises ALL problems in the textbook.

 All lecture PowerPoint slides will be available on WebCT no later than the evening before the lecture.


Exam dates & times:

 Midterm Exam: Thursday 11 February, 6-8 pm, rooms TBA ) (Please note there will be no lecture on the Wed. before)

 Final Exam: See Exam Schedule (TBA)


Exams, Quizzes & Exam Policy   Midterm exam: multiple choice – 35%

Covers Lectures 1-14.   Final exam: multiple choice and short

answer – 65% Covers Lectures 15-37.   No make-up exams.   Bring medical excuse to Ms. Hewitt, W3-25A Stewart

Biology Bldg if you miss the midterm exam.   If you miss the midterm, the final will be counted for

100%.   There is a supplemental/deferred exam* given in late

August. (*The supplemental exam and the deferred exams are identical and cover the entire course.)

A Student Response System (Clickers) consists of hardware and software that facilitate interactive learning activities. In general, the system allows an instructor to project a multiple-choice question to the students who then submit their responses using a handheld transmitter (often called a clicker). Software on the instructor's computer collects the students' answers and produces a histogram showing the distribution of student responses in real time.

Clickers

Clickers used, but not for grading

Lecturers use clicker questions to: 1. evaluate understanding of basic course

material. 2. encourage active participation and

thinking during lectures. 3. give students the chance to solve sample

exam questions in class.

StudentsmustregistertheirclickerinmyCourses(WebCTVista)

Studentsshouldregistertheirclickers,evenifyouareusingtheminanonymousmode.Thisisadifferentprocedurethaninthepast;itwillhelpustrackthenumberofclickersbeingusedatMcGillaswellasfacilitatethereturnoflostclickers.

*PleaseregistertheirclickerbyselecGngthe“Registeryourclicker”linkinyourmyCourses(WebCTVista)course.


Course overview: Read Chapter 1 for (p)review

From classical Mendelian Genetics to 21st century Molecular Genetics, with reference to the

applications of genetics in medicine, agriculture & basic research

Which of the following statements is correct?

1.  Testing for genetic diseases in humans no longer relies upon Mendelian genetics.

2.  Plant breeding no longer relies upon Mendelian genetics to produce improvements in harvest.

3.  Forensic genetics no longer relies upon Mendelian genetics for test.

4.  None of above.


Figure 1-2

Genetics and information transferEach cell contains chromosomes, and chromosomes contain genes


From Classical to Molecular Genetics


Approaches in genetics: Forward Genetics


Approaches in genetics: Reverse Genetics


PHENOTYPES are produced when genes interact with the environment (both external and developmental)

The APOE e4 allele is associated with late-onset Alzheimer’s disease (AD). 1.  If you have 0 APOe4 alleles your risk of AD is 0%.

2.  If you have 1 APOe4 alleles your risk of AD is 50%.

3.  If you have 2 APOe4 alleles your risk of AD is 100%.

4.  None of the above.


Genetics: A summing up of the science

Chromosome mapping

Mutation Replication of DNA

Transcription and regulation of transcription

Protein synthesis

Genes and development

Genomes

Quantitative genetics

Genes in populations

Genetic engineering

(gene isolation/

manipulation)

Medical genetics

Agricultural genetics

Evolutionary genetics


Lecture 1: Introduction to Biology 202

 Course information & organization  Course Overview  Overview of Genetics – past & present

Copies of Powerpoint slides & audio + video recordings of the lectures will be available on WebCT (http://webCT.mcgill.ca)


Lecture 2: Single Gene Inheritance I

 Genes and chromosomes.

 Inheritance patterns (Law of equal segregation).

 Chromosomal basis of single gene inheritance patterns.

 Introduction to problem solving in Genetics.

Readings: Pages 37-52, 54-56 (9th ed.) Pages 28-36, 90-99 (8th ed.)

lecture 1:introduction to biology 202 - amazon s3

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