digestion
DESCRIPTION
Digestion. All animals are heterotrophs Different modes of feeding evolved Modes of feeding (structure-function) can be used as an evolutionary evidence Compartmentalization. Intracellular vs. Extracellular. Intracellular- occurs within food vacuoles - PowerPoint PPT PresentationTRANSCRIPT
Digestion
• All animals are heterotrophs
• Different modes of feeding evolved
• Modes of feeding (structure-function) can be used as an evolutionary evidence
• Compartmentalization
Intracellular vs. Extracellular
• Intracellular- occurs within food vacuoles– E.g. food vacuoles in Paramecium,
amoebocytes of sponge
• Extracellular- occurs within specialized compartments– Incomplete vs. complete
Incomplete
• A single opening is present for both entrance of food and exit of wastes
• Gastrovascular cavity of Cnidarians
• Gastrodermis- has specialized cells that secrete digestive enzymes
• Hydrolysis of macromolecules is intracellular
Incomplete
Obelia sp.
Complete
• Opening of food is different from exit of waste materials
• Specialized regions of the alimentary canal
• Complexity varies in each phylum
• Extracellular hydrolysis of food
Complete
Bos taurus
Modes of feeding
• Herbivore
• Carnivore
• Omnivore– Dentition– Alimentary canal
Modes of Feeding
• Suspension feeders
• Substrate feeders
• Fluid feeders
• Bulk feeders
Modes of Feeding
Symbiotic Relationship
• Vertebrates acquired symbiotic relationship with microscopic organisms in processing food
• E.g. Ruminants, Humans, termites
Four Main Stages of Food Processing
• Ingestion– Large oral cavity
• Digestion– Mechanical vs. Chemical
• Absorption
• Elimination
Digestion in Humans
• Primary organs of digestion– Mouth, pharynx,
esophagus, stomach, small intestine, large intestine
• Accessory glands of digestion– Salivary glands,
pancreas, liver, gall bladder
Digestion in Humans
• Mouth- functions: ingestion and digestion
• Digestion begins in the Oral Cavity– Mechanical and Chemical digestion– Salivary amylase- breaks down
polysaccharide and glycogen– Saliva- also fxns as antibacterial agent and
neutralizes acidity of foods
Pharynx
• Upper portion of the throat
• Where air and digested food meet
• Digested ball (bolus) of food enters
• Epiglottis- acts as a seal to prevent food from entering the air passages
Esophagus
• Upper portion- striated muscle
• Lower portion- smooth muscle
• Connects the pharynx to the stomach
• Peristalsis
• Goblet cells- specialized cells that lines the esophagus– Release mucus that covers the bolus
Peristalsis
• Wave-like motion responsible for the movement of digested food in the alimentary canal
Stomach
• Stores and digests food
• Cardiac sphincter- prevents backflow
• Pyloric sphincter- regulates entrance of acidic chyme to the small intestine
• Secretes digestive juice– Mixed with food through churning of the
stomach through smooth muscle contractions
Stomach
• Chief cells- secretes pepsinogen
• Parietal cells- secrete HCl
• HCl- disrupts the extracellular matrix of plant and animal cell
• Pepsin- active form of pepsinogen– Hydrolyzes proteins– Works best in an acidic environment
Stomach
• Stomach lining is protected– First, pepsinogen is only activated when
secreted into the lumen due to the action of the acidic HCl (pepsinogen activation-positive feedback)
– Secondly, presence of goblet cells that secrete mucus
• product- acid chyme
Stomach
Small Intestine
• Major organ of digestion and absorption
• Longest section of the alimentary canal
• Divided into three sections:duodenum, jejunum, ileum
• Duodenum- site of mixing of acidic chyme and other digestive juices (digestion)
• Jejunum and Ileum- absorption
Small Intestine
• Carbohydrate digestion
• Protein Digestion
• Nucleic Acid Digestion
• Fatty Acid Digestion
Carbohydrate digestion
• Starch, glycogen and other polysaccharides that were digested in the mouth is further digested
• Pancreatic amylase
• Maltase- splits maltose into its glucose units
• Disaccharides- absorbed by intestinal epithelium
Protein digestion
• Trypsin and Chymotrypsin- breakdown large polypeptide chain like pepsin
• Dipeptidase- split small peptides• Carboxypeptidase- breakdown
polypeptides in its carboxyl end• Aminopeptidase- breakdown peptidase in
its nitrogenous end• Enteropeptidase- activates pancreatic
enzymes
Protein digestion
• Intestinal enzymes- aminopeptidase, enteropeptidase
• Pancreatic enzymes- Trypsinogen, Procarboxypeptidase, Chymotrypsinogen– Enteropeptidase- activates Trypsinogen– Trypsin- activates Procarboxypeptidase,
Chymotrypsinogen
Nucleic Acid Digestion
• Nucleases- hydrolyze nucleic acids
• Exonucleases- hydrolyze nucleic acids on its terminal
• Endonucleases- hydrolyze nucleic acids within
• Other enzymes hydrolyze the nucleotides into its components
Fatty acid digestion
• Bile salts- emulsify undigested fats in the duodenum– Emulsification- inc SA of fat molecules
• Lipase- digests fat molecules
Absorption
• Villus- folds found in the small intestine
• Microvillus- microscopic fingerlike projections that increases the absorption of materials
• Each villus is connected to a capillary (BV) network and lacteals(Lymphatic system)
Transport of nutrients
• Passive Diffusion
• Active transport
– Nutrients that were absorbed are transformed into what the body needs
– Chylomicron- small globule that is a combination of fats, cholesterol, coated with proteins
Hormones that regulate digestion
• Gastrin-stimulated by gastric juices– Inhibited by low pH– stimulates secretion of gastric juice
• Enterogastrones- group of enzymes found in the duodenum
• Cholecystokinin (CCK)- stimulated by fats and amino acids– Stimulates gall bladder to release bile
• Secretin- stimulated by the acidic chyme– Stimulates pancreas to release bicarbonates
– If chyme is rich in fats, it stimulates the duodenum to release other enzymes to slows down digestion in the stomach
Large Intestine
• Also called the colon• Cecum – small pouch that has different fxns• Appendix- small cecum found in man• Rectum- portion of the large intestine that
temporarily stores feces• Main fxn of colon is to reabsorb water• Feces- waste that was formed after digestion
• Compactness depends on water that was reabsorbed
Large Intestine
• Intestinal Bacteria- common example is E. coli
• Have mutualistic relationship with host
• Generate methane or hydrogen sulfide
• Some produce vitamins that are needed by the body
Nutrition
• Nutritionally adequate diet
– composed of:
• fuel (chemical energy)
• organic raw materials (carbon skeletons)
• essential nutrients (substances the animal cannot make)
Balancing the fuel
• Homeostatic mechanism balances the animal’s fuel
• ATPs that were produced are budgeted depending on the energy requirements
• Fats have the highest amount of ATP
• Glucose conversion is an example of homeostatic mechanism
Caloric Imbalance
• Undernourishment– Calorie deficiency
• Overnourishment– Excessive calorie intake- results to obesity
• Malnourishment– Deficient in any essential nutrients
Essential Nutrients
• Essential Amino Acids
• Essential Fatty Acids
• Vitamins
• Minerals
Essential Amino Acids
• Tryptophan, methionine, Valine, Threonine, Phenylalanine, Leucine, Isoleucine, Lysine, Histidine (infants)
• Deficiency in one of these may
result into protein deficiency
Essential Fatty Acids
• Essential Fatty Acids belong to the unsaturated fatty acid groups
• An example is linoleic acid
• Deficiencies are rare
Vitamins
• Organic molecules that are required relatively in small amount
• Two types:– Water-soluble
• B vits, C
– Fat-soluble• A, D, E, K
Minerals
• Inorganic nutrients that are required in small amounts
• E.g. Calcium, Phosphorous, Sodium, etc.
Balance diet
• what enters= what leaves
• It is easier to take in calories in the body than to burn it
• The food pyramid serves
as a guide in the kind
of foods that should be
taken in