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Digestion. All animals are heterotrophs Different modes of feeding evolved Modes of feeding (structure-function) can be used as an evolutionary evidence Compartmentalization. Intracellular vs. Extracellular. Intracellular- occurs within food vacuoles - PowerPoint PPT Presentation

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Page 1: Digestion
Page 2: Digestion

Digestion

• All animals are heterotrophs

• Different modes of feeding evolved

• Modes of feeding (structure-function) can be used as an evolutionary evidence

• Compartmentalization

Page 3: Digestion
Page 4: Digestion

Intracellular vs. Extracellular

• Intracellular- occurs within food vacuoles– E.g. food vacuoles in Paramecium,

amoebocytes of sponge

• Extracellular- occurs within specialized compartments– Incomplete vs. complete

Page 5: Digestion

Incomplete

• A single opening is present for both entrance of food and exit of wastes

• Gastrovascular cavity of Cnidarians

• Gastrodermis- has specialized cells that secrete digestive enzymes

• Hydrolysis of macromolecules is intracellular

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Incomplete

Obelia sp.

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Complete

• Opening of food is different from exit of waste materials

• Specialized regions of the alimentary canal

• Complexity varies in each phylum

• Extracellular hydrolysis of food

Page 9: Digestion

Modes of feeding

• Herbivore

• Carnivore

• Omnivore– Dentition– Alimentary canal

Page 10: Digestion

Modes of Feeding

• Suspension feeders

• Substrate feeders

• Fluid feeders

• Bulk feeders

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Modes of Feeding

Page 12: Digestion

Symbiotic Relationship

• Vertebrates acquired symbiotic relationship with microscopic organisms in processing food

• E.g. Ruminants, Humans, termites

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Four Main Stages of Food Processing

• Ingestion– Large oral cavity

• Digestion– Mechanical vs. Chemical

• Absorption

• Elimination

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Digestion in Humans

• Primary organs of digestion– Mouth, pharynx,

esophagus, stomach, small intestine, large intestine

• Accessory glands of digestion– Salivary glands,

pancreas, liver, gall bladder

Page 15: Digestion

Digestion in Humans

• Mouth- functions: ingestion and digestion

• Digestion begins in the Oral Cavity– Mechanical and Chemical digestion– Salivary amylase- breaks down

polysaccharide and glycogen– Saliva- also fxns as antibacterial agent and

neutralizes acidity of foods

Page 16: Digestion

Pharynx

• Upper portion of the throat

• Where air and digested food meet

• Digested ball (bolus) of food enters

• Epiglottis- acts as a seal to prevent food from entering the air passages

Page 17: Digestion

Esophagus

• Upper portion- striated muscle

• Lower portion- smooth muscle

• Connects the pharynx to the stomach

• Peristalsis

• Goblet cells- specialized cells that lines the esophagus– Release mucus that covers the bolus

Page 18: Digestion

Peristalsis

• Wave-like motion responsible for the movement of digested food in the alimentary canal

Page 19: Digestion

Stomach

• Stores and digests food

• Cardiac sphincter- prevents backflow

• Pyloric sphincter- regulates entrance of acidic chyme to the small intestine

• Secretes digestive juice– Mixed with food through churning of the

stomach through smooth muscle contractions

Page 20: Digestion

Stomach

• Chief cells- secretes pepsinogen

• Parietal cells- secrete HCl

• HCl- disrupts the extracellular matrix of plant and animal cell

• Pepsin- active form of pepsinogen– Hydrolyzes proteins– Works best in an acidic environment

Page 21: Digestion

Stomach

• Stomach lining is protected– First, pepsinogen is only activated when

secreted into the lumen due to the action of the acidic HCl (pepsinogen activation-positive feedback)

– Secondly, presence of goblet cells that secrete mucus

• product- acid chyme

Page 22: Digestion

Stomach

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Small Intestine

• Major organ of digestion and absorption

• Longest section of the alimentary canal

• Divided into three sections:duodenum, jejunum, ileum

• Duodenum- site of mixing of acidic chyme and other digestive juices (digestion)

• Jejunum and Ileum- absorption

Page 24: Digestion

Small Intestine

• Carbohydrate digestion

• Protein Digestion

• Nucleic Acid Digestion

• Fatty Acid Digestion

Page 25: Digestion

Carbohydrate digestion

• Starch, glycogen and other polysaccharides that were digested in the mouth is further digested

• Pancreatic amylase

• Maltase- splits maltose into its glucose units

• Disaccharides- absorbed by intestinal epithelium

Page 26: Digestion

Protein digestion

• Trypsin and Chymotrypsin- breakdown large polypeptide chain like pepsin

• Dipeptidase- split small peptides• Carboxypeptidase- breakdown

polypeptides in its carboxyl end• Aminopeptidase- breakdown peptidase in

its nitrogenous end• Enteropeptidase- activates pancreatic

enzymes

Page 27: Digestion

Protein digestion

• Intestinal enzymes- aminopeptidase, enteropeptidase

• Pancreatic enzymes- Trypsinogen, Procarboxypeptidase, Chymotrypsinogen– Enteropeptidase- activates Trypsinogen– Trypsin- activates Procarboxypeptidase,

Chymotrypsinogen

Page 28: Digestion

Nucleic Acid Digestion

• Nucleases- hydrolyze nucleic acids

• Exonucleases- hydrolyze nucleic acids on its terminal

• Endonucleases- hydrolyze nucleic acids within

• Other enzymes hydrolyze the nucleotides into its components

Page 29: Digestion

Fatty acid digestion

• Bile salts- emulsify undigested fats in the duodenum– Emulsification- inc SA of fat molecules

• Lipase- digests fat molecules

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Absorption

• Villus- folds found in the small intestine

• Microvillus- microscopic fingerlike projections that increases the absorption of materials

• Each villus is connected to a capillary (BV) network and lacteals(Lymphatic system)

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Transport of nutrients

• Passive Diffusion

• Active transport

– Nutrients that were absorbed are transformed into what the body needs

– Chylomicron- small globule that is a combination of fats, cholesterol, coated with proteins

Page 32: Digestion

Hormones that regulate digestion

• Gastrin-stimulated by gastric juices– Inhibited by low pH– stimulates secretion of gastric juice

• Enterogastrones- group of enzymes found in the duodenum

• Cholecystokinin (CCK)- stimulated by fats and amino acids– Stimulates gall bladder to release bile

• Secretin- stimulated by the acidic chyme– Stimulates pancreas to release bicarbonates

– If chyme is rich in fats, it stimulates the duodenum to release other enzymes to slows down digestion in the stomach

Page 33: Digestion

Large Intestine

• Also called the colon• Cecum – small pouch that has different fxns• Appendix- small cecum found in man• Rectum- portion of the large intestine that

temporarily stores feces• Main fxn of colon is to reabsorb water• Feces- waste that was formed after digestion

• Compactness depends on water that was reabsorbed

Page 34: Digestion

Large Intestine

• Intestinal Bacteria- common example is E. coli

• Have mutualistic relationship with host

• Generate methane or hydrogen sulfide

• Some produce vitamins that are needed by the body

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Nutrition

• Nutritionally adequate diet

– composed of:

• fuel (chemical energy)

• organic raw materials (carbon skeletons)

• essential nutrients (substances the animal cannot make)

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Balancing the fuel

• Homeostatic mechanism balances the animal’s fuel

• ATPs that were produced are budgeted depending on the energy requirements

• Fats have the highest amount of ATP

• Glucose conversion is an example of homeostatic mechanism

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Caloric Imbalance

• Undernourishment– Calorie deficiency

• Overnourishment– Excessive calorie intake- results to obesity

• Malnourishment– Deficient in any essential nutrients

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Essential Nutrients

• Essential Amino Acids

• Essential Fatty Acids

• Vitamins

• Minerals

Page 39: Digestion

Essential Amino Acids

• Tryptophan, methionine, Valine, Threonine, Phenylalanine, Leucine, Isoleucine, Lysine, Histidine (infants)

• Deficiency in one of these may

result into protein deficiency

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Essential Fatty Acids

• Essential Fatty Acids belong to the unsaturated fatty acid groups

• An example is linoleic acid

• Deficiencies are rare

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Vitamins

• Organic molecules that are required relatively in small amount

• Two types:– Water-soluble

• B vits, C

– Fat-soluble• A, D, E, K

Page 42: Digestion

Minerals

• Inorganic nutrients that are required in small amounts

• E.g. Calcium, Phosphorous, Sodium, etc.

Page 43: Digestion

Balance diet

• what enters= what leaves

• It is easier to take in calories in the body than to burn it

• The food pyramid serves

as a guide in the kind

of foods that should be

taken in