Condensed PowerPoint

Download Condensed PowerPoint

Post on 30-Jun-2015

1.858 views

Category:

Health & Medicine

2 download

Embed Size (px)

TRANSCRIPT

<ul><li> 1. Systemic disease and the eye</li></ul> <p> 2. Common systemic diseases affecting the eye </p> <ul><li>Infectious </li></ul> <ul><li>Toxoplasmosis </li></ul> <ul><li>Toxocariasis </li></ul> <ul><li>TB </li></ul> <ul><li>Syphilis </li></ul> <ul><li>Leprosy </li></ul> <ul><li>HIV </li></ul> <ul><li>CMV </li></ul> <ul><li>Non-infectious </li></ul> <ul><li>Endocrine diabetes, thyroid </li></ul> <ul><li>Connective tissue disease RA/ SLE/ Wegeners/ PAN/ Systemic sclerosis </li></ul> <ul><li>Vasculitides (GCA) </li></ul> <ul><li>Sarcoidosis </li></ul> <ul><li>Behcets Disease </li></ul> <ul><li>Vogt Koyanagi Harada syndrome </li></ul> <ul><li>Phakomatoses</li></ul> <p> 3. 1. Soft tissue involvement </p> <ul><li>Periorbital and lid swelling </li></ul> <ul><li>Conjunctival hyperaemia </li></ul> <ul><li>Chemosis </li></ul> <ul><li>Superior limbic keratoconjunctivitis </li></ul> <p>2.Eyelid retraction 3.Proptosis 4.Optic neuropathy 5.Restrictive myopathy THYROID EYE DISEASE 4. Soft tissue involvement Periorbital and lid swelling Chemosis Conjunctival hyperaemia Superior limbickeratoconjunctivitis 5. Signs of eyelid retraction Occurs in about 50% </p> <ul><li>Bilateral lid retraction</li></ul> <ul><li>No associated proptosis</li></ul> <ul><li>Bilateral lid retraction</li></ul> <ul><li>Bilateral proptosis</li></ul> <ul><li>Lid lag in downgaze</li></ul> <ul><li>Unilateral lid retraction</li></ul> <ul><li>Unilateral proptosis</li></ul> <p> 6. Proptosis Treatment options </p> <ul><li>Systemic steroids</li></ul> <ul><li>Radiotherapy</li></ul> <ul><li>Surgical decompression</li></ul> <ul><li>Occurs in about 50%</li></ul> <ul><li>Uninfluenced by treatment of hyperthyroidism</li></ul> <p>Axial and permanent in about 70%May be associated with choroidal folds 7. Optic neuropathy </p> <ul><li>Occurs in about 5%</li></ul> <ul><li>Early defective colour vision</li></ul> <ul><li>Usually normal disc appearance</li></ul> <p>Caused by optic nerve compression atorbital apex by enlarged rectiOften occurs in absence of significantproptosis 8. </p> <ul><li>Occurs in about 40%</li></ul> <ul><li>Due to fibrotic contracture</li></ul> <p>Restrictive myopathy Elevation defect - most common Abduction defect - less commonDepression defect -uncommon Adduction defect - rare 9. SARCOIDOSIS </p> <ul><li>Idiopathic multisystem disorder </li></ul> <ul><li>Characterised by non-caseating granulomata </li></ul> <ul><li>More common in women 20-50 yrs </li></ul> <ul><li>More common in blacks and Asians </li></ul> <ul><li>? Related to mycobacteria </li></ul> <p> 10. SARCOIDOSIS Systemic Involvement </p> <ul><li>Lung lesions 95% </li></ul> <ul><li>Thoracic lymph nodes 50% </li></ul> <ul><li>Skin lesions 30% </li></ul> <ul><li>Eyes 30% </li></ul> <p> 11. SARCOIDOSIS Ocular Involvement </p> <ul><li>Anterior segment lesions (30%) </li></ul> <ul><li><ul><li>Conjunctival granuloma </li></ul></li></ul> <ul><li><ul><li>Lacrimal gland involvement/dry eye </li></ul></li></ul> <ul><li><ul><li>Acute or chronic uveitis </li></ul></li></ul> <ul><li><ul><li>KPs described as mutton fat because they are large and greasy </li></ul></li></ul> <p> 12. SARCOIDOSIS Ocular Involvement </p> <ul><li>Posterior segment lesions (20%) </li></ul> <ul><li><ul><li>Patchy venous sheathing </li></ul></li></ul> <ul><li><ul><li>Cellular infiltrate around vessels </li></ul></li></ul> <ul><li><ul><li>Chorioretinal granulonmas </li></ul></li></ul> <ul><li><ul><li>Vasculitis including occlusive causing:- </li></ul></li></ul> <ul><li><ul><li>Neovascularisation </li></ul></li></ul> <ul><li><ul><li>Infiltrate in vitreous (vitritis) including cell clumps (snowballs) </li></ul></li></ul> <p> 13. SARCOIDOSIS Ocular Involvement </p> <ul><li>Sheathing of the retinal veins </li></ul> <ul><li>Fluorescein angiography showing leakage and staining at sites of sheathing </li></ul> <p> 14. SARCOIDOSIS Granuloma in Fundus </p> <ul><li>Retinal and pre-retinal </li></ul> <ul><li>Choroidal</li></ul> <p> 15. SARCOIDOSIS Granuloma in Fundus </p> <ul><li>Optic nerve head granuloma </li></ul> <ul><li>Normal optic nerve head </li></ul> <p> 16. SARCOIDOSIS Systemic Signs </p> <ul><li>Lupus pernio affecting the nose a chronic progressive cutaneous sarcoid that most commonly affects face and ears </li></ul> <p> 17. SARCOIDOSIS Systemic signs </p> <ul><li>Facial palsy </li></ul> <ul><li>Salivary gland enlargement </li></ul> <p> 18. SARCOIDOSIS Systemic signs </p> <ul><li>Hilar adenopathy on chest x-ray </li></ul> <ul><li>Lung infiltrate </li></ul> <ul><li>Erythema nodosum </li></ul> <ul><li>Arthritis </li></ul> <p> 19. SARCOIDOSIS Investigations (1) </p> <ul><li>CXR to detect pulmonary signs </li></ul> <ul><li>Bilateral hilar lymph-adenopathy </li></ul> <ul><li>Pulmonary mottling </li></ul> <p> 20. SARCOIDOSIS Investigations (2) </p> <ul><li>Serum angiotensin-converting enzyme (ACE) elevated in active sarcoidosis </li></ul> <ul><li>Mantoux test caution in patients who have had BCG vaccination. Test may be negative </li></ul> <ul><li>Lung function tests </li></ul> <p> 21. SARCOIDOSIS Investigations (3) </p> <ul><li>Gallium scan showing increased uptake in the lacrimal and parotid glands and pulmonary regions in a patient with active sarcoidosis </li></ul> <p> 22. SARCOIDOSIS Treatment </p> <ul><li>Systemic steroids may be necessary in patients with posterior segment disease where vision is threatened, especially if optic nerve is involved </li></ul> <p> 23. PHACOMATOSES 1.Neurofibromatosis 2.Tuberous sclerosis (Bourneville disease) 3.von-Hippel-Lindau syndrome 4.Sturge-Weber syndrome </p> <ul><li>Type I (NF-1) - von Recklinghausen disease </li></ul> <ul><li>Type II (NF-2) - bilateral acoustic neuromas </li></ul> <p> 24. Neurofibromatosis type-1 -(NF-1) Appear during first year of life Caf-au-lait spots </p> <ul><li>Most common phacomatosis </li></ul> <p>Increase in size and numberthroughout childhood </p> <ul><li>Affects 1:4000 individuals </li></ul> <ul><li>Presents in childhood </li></ul> <ul><li>Gene localized to chromosome 17q11 </li></ul> <p> 25. Fibroma molluscum in NF-1 </p> <ul><li>Appear at puberty </li></ul> <ul><li>Pedunculated, flabby nodules consisting of</li></ul> <ul><li>neurofibromas or schwannomas </li></ul> <ul><li>Increase in number</li></ul> <ul><li>throughout life </li></ul> <ul><li>Usually widely distributed </li></ul> <p> 26. Plexiform neurofibroma in NF-1 </p> <ul><li>May be associated with</li></ul> <ul><li>overgrowth of skin </li></ul> <ul><li>Appear during childhood </li></ul> <ul><li>Large and ill-defined </li></ul> <p> 27. Skeletal defects in NF-1</p> <ul><li>Mild head enlargement - uncommon </li></ul> <ul><li>Other - scoliosis, short stature, thinning</li></ul> <ul><li>of long bones </li></ul> <ul><li>Facial hemiatrophy </li></ul> <p> 28. Orbital lesions in NF-1 Spheno-orbital encephalocele Optic nerve glioma in 15% </p> <ul><li>Sagittal MRI scan of optic nerve</li></ul> <ul><li>glioma invading hypothalamus </li></ul> <ul><li>Glioma may be uni or bilateral </li></ul> <ul><li>Axial CT scan of congenital absence</li></ul> <ul><li>of left greater wing of sphenoid bone </li></ul> <ul><li>Pulsating proptosis without bruit! </li></ul> <p> 29. Eyelid neurofibromas in NF-1 Nodular Plexiform May cause mechanical ptosis May be associated with glaucoma 30. Intraocular lesions in NF-1 Lisch nodules Very common - eventually present in 95% of cases Congenital ectropion uveae Uncommon - may beassociated with glaucoma Retinal astrocytomas Rare - identical to those seenIn tuberous sclerosis Choroidal naevi Common - may beMultifocal and bilateral 31. Ocular features of NF-2 Common - combined hamartomas ofRPE and retinaVery common - presenile cataract 32. Tuberous sclerosis (Bourneville disease) </p> <ul><li>Diffuse thickening over</li></ul> <ul><li>lumbar region </li></ul> <ul><li>Present in 40% </li></ul> <p>Shagreen patches </p> <ul><li>Autosomal dominant </li></ul> <ul><li>Triad - mental handicap, epilepsy, adenoma sebaceum </li></ul> <p>Adenoma sebaceum </p> <ul><li>Around nose and</li></ul> <ul><li>cheeks </li></ul> <ul><li>Appear after age 1</li></ul> <ul><li>and slowly enlarge </li></ul> <p>Ash leaf spots </p> <ul><li>Hypopigmented skin patches</li></ul> <ul><li>In infants best detected using</li></ul> <ul><li>ultraviolet light (Woods lamp) </li></ul> <p> 33. Systemic hamartomas in tuberous sclerosis Astrocytic cerebral hamartomas </p> <ul><li>Slow-growing periventricular tumours </li></ul> <ul><li>May cause hydrocephalus, epilepsy and</li></ul> <ul><li>mental retardation </li></ul> <ul><li>Usually asymptomatic and</li></ul> <ul><li>innocuous </li></ul> <ul><li>Kidneys (angiomyolipoma),</li></ul> <ul><li>heart (rhabdomyoma)</li></ul> <p>Visceral and subungual hamartomas 34. Retinal astrocytomas in tuberous scleritisDense white tumour Mulberry-like tumour Early</p> <ul><li>Innocuous tumour present in 50% of patients </li></ul> <ul><li>May be multiple and bilateral </li></ul> <p>Semitranslucent nodule White plaque Advanced 35. Systemic features of v-H-L syndrome Autosomal dominant </p> <ul><li>Tumours - renal</li></ul> <ul><li>carcinoma and</li></ul> <ul><li>phaeochromocytoma </li></ul> <ul><li>Cysts - kidneys, liver, </li></ul> <ul><li>pancreas, epididymis,</li></ul> <ul><li>ovary and lungs </li></ul> <ul><li>Polycythaemia </li></ul> <p>CNS Haemangioblastoma MRI-spinal cord tumour Angiogram of cerebellartumour Visceral tumours 36. Retinal capillary haemangiomain v-H-L syndrome Round orange-red mass Early</p> <ul><li>Vision-threatening tumour present in 50% of patients </li></ul> <ul><li>May be multiple and bilateral </li></ul> <p>Tiny lesion betweenarteriole and venuole Small red nodule Associated dilatation andtortuosity of feeder vessels Advanced 37. Systemic features of Sturge-Weber syndrome </p> <ul><li>Congenital, does not</li></ul> <ul><li>blanche with pressure </li></ul> <ul><li>Associated with ipsilateral</li></ul> <ul><li>glaucoma in 30% of cases </li></ul> <p>Naevus flammeus </p> <ul><li>CT scan showing left</li></ul> <ul><li>parietal haemangioma </li></ul> <ul><li>Complications mental retard,</li></ul> <ul><li>epilepsy and hemiparesis </li></ul> <p>Meningeal haemangioma 38. Ocular features of Sturge-Weber syndrome Normal eye Buphthalmos in 60% May be associated withepiscleral haemangioma Affected eye Diffuse choroidal haemangioma Glaucoma 39. Peripheral corneal involvement inrheumatoid arthritis </p> <ul><li>Chronic and asymptomatic </li></ul> <ul><li>Circumferential thinning with intact</li></ul> <ul><li>epithelium (contact lens cornea) </li></ul> <ul><li>Acute and painful </li></ul> <ul><li>Circumferential ulceration and</li></ul> <ul><li>infiltration </li></ul> <p>Treatment- systemic steroids and/or cytotoxic drugs Without inflammationWith inflammation 40. Peripheral corneal involvement inWegener granulomatosis and polyarteritis nodosa Circumferential and central ulceration similar to Mooren ulcer Unlike Mooren ulcer sclera may also become involved Treatment- systemic steroids and cyclophosphamide 41. Ocular manifestations of HIV infection 42. Introduction </p> <ul><li>AIDS is an infectious disease caused by the gradual decrease inCD4+ T lymphocytescausing subsequent opportunistic infections and neoplasia. It is a blood borne and sexually transmitted infection caused by the HIV (Human Immunodeficiency Virus) </li></ul> <ul><li>Approximately 36 million persons around the world are infected. Up to 70% of patients infected with HIV will develop some form of ocular involvement, ie: direct infection by HIV,opportunistic infections and neoplasia. </li></ul> <ul><li>HIV infection progresses thoughdifferent phases </li></ul> <p> 43. 44. Ophthalmic Manifestations of HIV Infection </p> <ul><li>AROUND THE EYE </li></ul> <ul><li><ul><li>Molluscum Contagiosum </li></ul></li></ul> <ul><li><ul><li>HerpesZoster Ophthalmicus </li></ul></li></ul> <ul><li><ul><li>KaposisSarcoma </li></ul></li></ul> <ul><li><ul><li>ConjunctivalSquamousCell Carcinoma </li></ul></li></ul> <ul><li><ul><li>Trichomegaly </li></ul></li></ul> <ul><li>FRONT OF THE EYE </li></ul> <ul><li><ul><li>Dry Eye </li></ul></li></ul> <ul><li><ul><li>Anterior Uveitis </li></ul></li></ul> <ul><li>BACK OF THE EYE </li></ul> <ul><li><ul><li>RetinalMicrovasculopathy </li></ul></li></ul> <ul><li><ul><li>CMVRetinitis </li></ul></li></ul> <ul><li><ul><li>Acute Retinal Necrosis </li></ul></li></ul> <ul><li><ul><li>Progressive Outer Retinal Necrosis </li></ul></li></ul> <ul><li><ul><li>Toxoplasmosis Retinochoroiditis </li></ul></li></ul> <ul><li><ul><li>SyphilisRetinitis </li></ul></li></ul> <ul><li><ul><li>Candida albicans endophthalmitis </li></ul></li></ul> <ul><li>NEURO-OPHTHALMIC </li></ul> <p> 45. Molluscum Contagiosum </p> <ul><li>Molluscum contagiosum is a viral infection of the skin. </li></ul> <ul><li>Affects up to 20% ofsymptomatic HIV infected patients. </li></ul> <ul><li>Clinically appears like painless, small, umbilicated nodules, which produce a waxy discharge when pressured. </li></ul> <ul><li>Treatment consists on excision of the lesion, curettage or cryotherapy </li></ul> <p> 46. Herpes Zoster Ophthalmicus </p> <ul><li>Due to the reactivation of a latent infection by Varicella Zoster Virus in the dorsal root of trigeminal nerve ganglion. </li></ul> <ul><li>It manifests with a maculo-papulo-vesicular rash which often is preceded by pain. Usually involves the upper lid and does not cross the midline</li></ul> <ul><li>Treatment consists on oral Aciclovir 800mg 5 times /day. In immunocompromised patients Aciclovir is given intravenously for two weeks. Ocular manifestations such as anterior uveitis, are treated with topical steroids and mydriatics. </li></ul> <p> 47. 48. Kaposis Sarcoma </p> <ul><li>Kaposis sarcoma is a vascular neoplasm which is almost exclusively seen in patients with AIDS. </li></ul> <ul><li>KS is the commonest anterior segment lesion seen in AIDS; appears as a violaceous non-tender nodule on the eyelid or conjunctiva. </li></ul> <ul><li>Typically KS involves only the skin but when there is a reduced CD4 count it can progress rapidly to other sites such as the gastrointestinal tract and CNS </li></ul> <ul><li>Treatment of ocular adnexal KS may be necessary for cosmesis and to relieve functional difficulties. The mainstay of treatment is radiotherapy. Other options include cryotherapy or chemotherapy. </li></ul> <p> 49. 50. Conjunctival Squamous Cell Carcinoma </p> <ul><li>Squamous cell carcinoma (SCC) is the third most common neoplasm associated to HIV infection.</li></ul> <ul><li>This may be due to an interaction between HIV, sunlight and Human Papilloma Virus infection. </li></ul> <ul><li>SCC appears as a pink, gelatinous growth, usually in the interpalpebral area. Often an engorged blood vessel feeding the tumour is seen.</li></ul> <ul><li>It may extend onto the cornea, but deep invasion and metastasis are rare.</li></ul> <ul><li>The treatment of choice is local excision and cryotherapy but the presence of orbital invasion is an indication of exenteration </li></ul> <p> 51. 52. Trichomegaly </p> <ul><li>Trichomegaly or hypertrichosis is an exaggerated growth of the eye lashes found in the later stages of the disease </li></ul> <ul><li>The cause is not known </li></ul> <ul><li>When symptomatic or for cosmetic reasons the eyelashes can be trimmed or plucked </li></ul> <p> 53. Dry Eye </p> <ul><li>Sicca syndrome is common with HIV infection </li></ul> <ul><li>Patients complain of burning uncomfortable red eyes. </li></ul> <ul><li>There are several causes of dry eye in HIV infection from blepharitis to destruction of the lacrimal glands. </li></ul> <ul><li>Treatment is with tear supplements</li></ul> <p> 54. Anterior Uveitis </p> <ul><li>HIV related anterior uveitis can be: </li></ul> <ul><li><ul><li>Direct manifestation of the HIV infection </li></ul></li></ul> <ul><li><ul><li>autoimmnune in origin </li></ul></li></ul> <ul><li><ul><li>drug induced ie: rifabutin, secondary to direct toxic effect upon the non-pigmented epithelium of the ciliary body. </li></ul></li></ul> <ul><li><ul><li>Any of the different infections associated with AIDS :-Herpes Zoster Virus,Herpes Simplex Virus, Cytomegalovirus,Toxoplasma gondiiSyphilis </li></ul></li></ul> <p> 55. Rifabutin induced anterior uveitis 56. Retinal microvasculitis </p> <ul><li>Retinal microvasculopathy occurs in more than half of the patients with HIV </li></ul> <ul><li>It is seen as transient cotton wool spots (CWS), intra-retinal haemorrhages and microaneurysm, </li></ul> <ul><li>Occurs in 50-70% of patients. It is usually asymptomatic. </li></ul> <ul><li>Unclear pathogenesis,but thought to be HIV infection of retinal vascular cells. </li></ul> <ul><li>Serological test for HIV will confirm the diagnosis. </li></ul> <ul><li>Treatment is based in delaying the progression of the disease associated with HIV. </li></ul> <p> 57. Cotton Wool Spots 58. CMV Retinitis </p> <ul><li>Introduction </li></ul> <ul><li><ul><li>CMV Retinitis is the commonest intraocular ocular opportunistic infection seen in patients with AIDS </li></ul></li></ul> <ul><li><ul><li>Antibodies are found in almost 95% of adults, causing a trivial illness in immunocompetent adults, however severe immunosuppression causes viral reactivation and tissue invasive disease </li></ul></li></ul> <ul><li>Pathogenesis </li></ul> <ul><li><ul><li>Reactivation from extraocular sites leads to seeding in other sites such as the retina </li></ul></li></ul> <ul><li>Epidemiology </li></ul> <ul><li><ul><li>The number of newly diagnosed cases of CMVR has decreased since the introduction of the HAART </li></ul></li></ul> <p>Highly Active Antiretroviral Therapy 59. CMV Retinitis </p> <ul><li>Clinical manifestations </li></ul> <ul><li><ul><li>Patientsmay complain of minor visual symptoms such as floaters, flashing lights or mild blurred vision, or be totally asymptomatic. </li></ul></li></ul> <ul><li><ul><li>It presents with a wide range of clinical appearances. From cotton wool spots which may look like HIV Retinopathy to confluent areas of full thickness retinal necrosis and vasculitis. CMVR can progress in a brushfire pattern from the active edge of an active lesion. The retinal vessels in an affected area show attenuation, becoming ghost vessels eventually. </li></ul></li></ul> <ul><li>Treatment </li></ul> <ul><li><ul><li>The treatment of CMVR in patients with AIDS requires the use of specific antiviral agents, ganciclovir, foscarnet or cidovir in conjunction with HAART. </li></ul></li></ul> <ul><li><ul><li>These treatments can be administered orally, intravenously or intravitreally. Systemic treatment has the advantage of treating infection elsewhere in the body as well as the other eye but has the disadvantages of systemic side effects. </li></ul></li></ul> <ul><li><ul><li>Intravitreal implants release the drug over a six-month period, achieving prolonged high intravitreal levelsof drug. </li></ul></li></ul> <p> 60. CMV Retinitis 61. Acute Retinal Necrosis </p> <ul><li>ARN is a confluent peripheral whitening of the retina with marked vitritis and blood vessel closure. Optic neuritis and retinal detachment are frequent complications. </li></ul> <ul><li>ARN is usually due to Varicella-Zoster infection, but it can also be caused by Herpes Simplex virus or Cytomegalovirus. </li></ul> <ul><li>Initially described in the immunocompetent, it has also been described in the immunosuppressed. </li></ul> <ul><li>The diagnosis is mainly clinical and is confirmed by PCR assays on vitreous samples. </li></ul> <ul><li>Patients are treated with high doses of intr