components of blood whole blood –rbcs –wbcs –platelets: cell fragments that aid in clotting...
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Components of Blood
• Whole blood– RBCs– WBCs– Platelets: cell fragments that aid in clotting
• Plasma– 90% water (allows materials to dissolve)– Amino acids, glucose, hormones, vitamins, salts, waste– Concentrations allows diffusion in/out of blood stream
Red Blood Cells
• Job: Transport O2 to cells• Produced from stem cells in bone marrow• O2 binds to hemoglobin proteins • Dead cells filtered by liver & spleen
NormalSickle Cell
White Blood Cells
• Remove foreign invaders & dead cells
• Able to move through body tissue
Platelets
• Form clots when bleeding
• Proteins form a web to trap cells & platelets
• Proteins on blood cells determine blood type• Antigen (markers)
– proteins on cell’s surface that identify cells as foreign or natural
• Antibodies:– proteins from B cells to attack invaders– Float freely in plasma
ABO Blood Groups
Group A blood
• A antigens on the surface of your RBCs
• B antibodies in your blood plasma
Group B blood
• B antigens on the surface of your RBCs
• A antibodies in your blood plasma
Group AB blood
• Both A and B antigens on the surface of your RBCs
• Neither A or B antibodies in your blood plasma
Group O blood
• Neither A or B antigens on the surface of your RBCs
• Both A and B antibodies in your blood plasma
If you have type A blood, can you receive:
Type B blood from a donor?
Type AB blood from a donor?
Type O blood from a donor?
If you have type B blood, can you receive:
Type A blood from a donor?
Type AB blood from a donor?
Type O blood from a donor?
If you have type AB blood, can you receive:
Type A blood from a donor?
Type B blood from a donor?
Type O blood from a donor?
If you have type O blood, can you receive:
Type A blood from a donor?
Type B blood from a donor?
Type AB blood from a donor?
Rh Factors• If Rh+
– Cells contain the Rh antigen
– Can receive Rh+ or Rh- blood
• If Rh-– Cells lack the Rh
antigen– Plasma contains
Rh antibody– Only receive Rh-
blood
Francis was just in a bad accident and lost a lot of blood. He is blood type B+. Can you help save him?
Blood type B+
Antigens: Which does he have?
A
B
Rh
Antibodies: Which does he have?
A
B
Rh
Will his antibodies attack this blood?
No. His A antibodies only attack A antigens.
Can he receive B+ blood?
Yes.
A antibody
A antibody
A antibody
Francis has B+ blood type because of the B and Rh antigens. If he is given B+ blood in a transfusion…
Vein
Francis has B+ blood type because of the B and Rh antigens. If he is given B- blood in a transfusion…
A antibody
A antibody
A antibody
Will his antibodies attack this blood?
No. His A antibodies only attack A antigens.
Can he receive B- blood?
Yes. Vein
Francis has B+ blood type because of the B and Rh antigens. If he is given A+ blood in a transfusion…
Will his antibodies attack this blood?
Yes. His A antibodies will attack the A antigens.
Can he receive A+ blood?
No.
A antibody
A antibody
A antibody
Vein
Agglutination: clumping of the
blood
Francis has B+ blood type because of the B and Rh antigens. If he is given A- blood in a transfusion…
Will his antibodies attack this blood?
Yes. His A antibodies will attack the A antigens.
Can he receive A- blood?
No.
A antibody
A antibody
A antibody
Vein
Agglutination: clumping of the
blood
Francis has B+ blood type because of the B and Rh antigens. If he is given AB+ blood in a transfusion…
Will his antibodies attack this blood?
Yes. His A antibodies will attack the A antigens.
Can he receive AB+ blood?
No.
A antibody
A antibody
A antibody
Vein
Agglutination: clumping of the
blood
Francis has B+ blood type because of the B and Rh antigens. If he is given AB- blood in a transfusion…
Will his antibodies attack this blood?
Yes. His A antibodies will attack the A antigens.
Can he receive AB- blood?
No.
A antibody
A antibody
A antibody
Vein
Agglutination: clumping of the
blood
Francis has B+ blood type because of the B and Rh antigens. If he is given O+ blood in a transfusion…
Will his antibodies attack this blood?
No. His A antibodies only attack A antigens.
Can he receive O+ blood?
Yes.
A antibody
A antibody
A antibody
Vein
Francis has B+ blood type because of the B and Rh antigens. If he is given O- blood in a transfusion…
A antibody
A antibody
A antibody
Will his antibodies attack this blood?
No. His A antibodies only attack A antigens.
Can he receive O- blood?
Yes. Vein
Sebastian was just involved in an accident at work and lost a lot of blood. He is blood type A-. Can you help save him?
Blood type A-
Antigens: Which does he have?
A
B
Rh
Antibodies: Which does he have?
A
B
Rh
Sebastian has A- blood type because of the A antigen. If he is given A- blood in a transfusion…
Will his antibodies attack this blood?
No. His B and Rh antibodies only attack B and Rh antigens.
Can he receive A- blood?
Yes.
B antibody
Rh antibody
B antibody
Rh antibody
Rh antibody
B antibody
Vein
Sebastian has A- blood type because of the A antigen. If he is given A+ blood in a transfusion…
B antibody
B antibody
Will his antibodies attack this blood?
Yes. His Rh antibodies will attack the donated Rh antigens.
Can he receive A+ blood?
No.
B antibody
Rh antibody
Rh antibody
Rh antibody
Agglutination: clumping of the
blood
Vein
Sebastian has A- blood type because of the A antigen. If he is given B- blood in a transfusion…
Rh antibody
Will his antibodies attack this blood?
Yes. His B antibodies will attack the donated B antigens.
Can he receive B- blood?
No.
Rh antibody
Rh antibody
B antibody
B antibody
B antibody
Agglutination: clumping of the
blood
Vein
Sebastian has A- blood type because of the A antigen. If he is given B+ blood in a transfusion…
Will his antibodies attack this blood?
Yes. Both his B and Rh antibodies will attack the donated B an Rh antigens.
Can he receive B+ blood?
No.
B antibody
Rh antibody
B antibody
Rh antibody
Rh antibody
B antibody
Agglutination: clumping of the
blood
Vein
Sebastian has A- blood type because of the A antigen. If he is given AB- blood in a transfusion…
Rh antibody
Will his antibodies attack this blood?
Yes. His B antibodies will attack the donated B antigens.
Can he receive AB- blood?
No.
Rh antibody
Rh antibody
B antibody
B antibody
B antibody
Agglutination: clumping of the
blood
Vein
Sebastian has A- blood type because of the A antigen. If he is given AB+ blood in a transfusion…
Will his antibodies attack this blood?
Yes. Both his B and Rh antibodies will attack the donated B and Rh antigens.
Can he receive AB+ blood?
No.
B antibody
Rh antibody
B antibody
Rh antibody
Rh antibody
B antibody
Agglutination: clumping of the
blood
Vein
Sebastian has A- blood type because of the A antigen. If he is given O+ blood in a transfusion…
B antibody
B antibody
Will his antibodies attack this blood?
Yes. His Rh antibodies will attack the donated Rh antigens.
Can he receive O+ blood?
No.
B antibody
Rh antibody
Rh antibody
Rh antibody
Agglutination: clumping of the
blood
Vein
Sebastian has A- blood type because of the A antigen. If he is given O- blood in a transfusion…
B antibody
Rh antibody
B antibody
Will his antibodies attack this blood?
No. His A antibodies only attack A antigens.
Can he receive O- blood?
Yes.
Rh antibody
Rh antibody
B antibody
Vein
Blood type AB+
Antigens: Which does they have?
A
B
Rh
Antibodies: Which does they have?
A
B
Rh
Blood type O+
Antigens: Which does they have?
A
B
Rh
Antibodies: Which does they have?
A
B
Rh
Blood type AB-
Antigens: Which does they have?
A
B
Rh
Antibodies: Which does they have?
A
B
Rh
Blood type B+
Antigens: Which does they have?
A
B
Rh
Antibodies: Which does they have?
A
B
Rh
Blood type O-
Antigens: Which does they have?
A
B
Rh
Antibodies: Which does they have?
A
B
Rh
1) Can this work?
• Acceptor
O-
• Donor
AB-
2) Can this work?
• Acceptor
A+
• Donor
A-
3) Can this work?
• Acceptor
AB-
• Donor
B-
Kobe Kuiz1) What are the components found inside blood?
2) What are the ingredients of plasma?
3) What is the purpose/function of RBCs?
4) Which part of blood stop bleeding when cut?
5) What do antibodies bind with?
6) If a person has type AB-, which antigens do they possess? Which antibodies?
7) If a person has type O+, which antigens do they possess? Which antibodies?
8) If a person is type A-, list all the blood types this person can receive in a transfusion.
9) If a person is type O-, list all the blood types this person can receive in a transfusion.