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Part A

1

2

3

4

Part B

Part C

A: Welcom

1. Overvie

2. Admiss

3. How to

4. Assess

B: Honou

C: Alterna

me

ew

sion

o Apply / U

sment

rs Supervi

atives for H

seful Inform

sors

Honours

2

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3

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12

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4

OVERVIEW OF HONOURS

This booklet provides details for students interested in undertaking an Honours year with a major in chemistry in either the BSc or BSc Advanced programs or undertaking a BSc Medicinal Chemistry (3992). If you are a BSc Nanotechnology (3617) student, please consult the specialised Honours booklet for your degree.

Is the Honours year worth the extra year it takes? The answer is certainly “Yes!” for many people.

The response from potential employers in industry and the public sector is that they will employ a good Honours graduate over someone with a pass degree.

Honours is necessary for anyone contemplating postgraduate study in chemistry. Honours gives you “hands-on” experience in tackling projects, and provides a

rewarding finishing quality to your education. Honours provides you with experience at managing your own project,

independence and time management skills. Most important of all, the Honours year allows you to work closely with the staff in

the School of Chemistry, and it transforms the University for you into a very human organisation that has people who support you.

HONOURS IN THE SCHOOL OF CHEMISTRY

In 2019 the School of Chemistry offers Honours programs that are suitable for students enrolled in Science, Advanced Science, Medicinal Chemistry and Environmental Science. The School of Chemistry also offers projects for Nanoscience students and projects are also accepted in other streams which can be discussed with the respective coordinators. School of Chemistry researchers also supervise or co-supervise the equivalent of a Honours project with colleagues in the Faculty of Science and in other Faculties which are typically made in a case by case basis.

Within the School of Chemistry all programs involve a proportion of coursework. BSc. Science or BSc. Advanced Science students with a major in Chemistry enrol in BSc. Honours (4500). Assessment is based entirely on your record during the Honours year, during which students have the opportunity to demonstrate skills in both research and coursework.

In the UNSW3+ model, the streamlined access to Honours is shown in the figure below. Students enrol in 48 credit points, first term of Honours in CHEM4501, CHEM4502 and CHEM4506, followed by CHEM4518 in your second term and

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9

ASSESSMENT

The Honours degree is graded into Class 1, Class 2 Division 1, Class 2 Division 2, Class 3 or Honours may not be awarded (see below for grade boundaries).

Assessment is on the basis of performance in the various components of the course, including the research project and the formal course work. Note that in order to be awarded Honours, you must achieve a satisfactory performance (>50%) in each component (coursework and research).

CHEM4501 - 6 UoC Research skills

CHEM4502 - 6 UoC Coursework

CHEM4506, CHEM4512 and CHEM4518 - 36 UoC Research

Thesis Grading Committee’s assessment of Thesis Thesis Grading Committee’s assessment of the Final Seminar Thesis Grading Committee’s assessment of the Defence Attendance at School Research Seminars

Research skills (CHEM4501 6 UoC – 12.5%): In order to adequately equip yourself for your research project, you are required to take CHEM4501 which will cover how to write a research proposal, presentation skills, research ethics, managing your research and occupational health and safety.

Course Work (CHEM4502 6 UoC – 12.5%): You are required to take three different short courses during your Honours year. Every term two of these courses are offered and are geared to be advanced level options of undergraduate knowledge. Details are available from the Honours Coordinator (Dr Neeraj Sharma). You will nominate the 3 courses typically when you commence Honours.

Research Component (CHEM4506, CHEM4512, CHEM4518 36 UoC - 75%): The research project is the distinctive feature of the Honours year. It is the major undertaking of the year and is both the most challenging and rewarding aspect of Honours.

Students work on original research projects conceived and overseen by a member of staff. While you will be instructed by your supervisor on the nature of the project and will be given guidance in how to conduct the project, it is expected that you will perform all experimental work independently. You will be expected to prepare and

10

analyse experimental results and work with your supervisor to identify and overcome any problems. At the completion of the year you will present a thesis detailing the background, aims, experimental procedures, results and future directions of your project.

Research Proposal and Presentation: To assist in the preparation of your thesis and to allow your writing style to be improved, you will also be required to submit a research report describing your chosen research project and a review of pertinent literature. You will also do a short presentation on the proposal and your project. This will be in the first term of your Honours year and written feedback will be provided for both aspects.

Thesis Submission: You will write your thesis and submit it during your third term in Honours with the dates made available on your first term. Your thesis is a significant portion of your Honours mark and should be read and edited by numerous people including your supervisor.

You are required to submit a final version of your thesis that incorporates the Thesis Committee’s comments to your supervisor and the School for completion of Honours. Failure to do so will result in your Honours grade being withheld. The thesis accounts for 60% of your research mark.

Honours Seminar: You will be expected to present your work at two seminars during your Honours year; one will be a short overview of your project in your first term which will be graded within your research skills component (see above); and a longer seminar detailing your results to be presented after submitting your thesis; this seminar is typically 15 minutes long plus up to 10 minutes for questions. It comprises 15% of your research mark.

Oral thesis defence (viva-voce): The thesis defence will be shortly after you have submitted your Honours thesis and presented your final seminar and will be a closed examination of around 20-30 minutes with a panel of experts. It will comprise 25% of your research mark.

Attendance at School Research Seminars: Attendance at School Research Seminars is compulsory.

HONOURS DEGREE GRADE BOUNDARIES (%) Class 1 85+

Class 2 Division 1 75 – 84

Class 2 Division 2 65 – 74

Class 3 50 – 64

11

12

HONOURS SUPERVISORS

A

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13

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14

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15

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16

ON/OFF catalytic activities. One example are spiropyran molecules, which act as ‘photoacids’, being switched between stable acidic and non-acidic states using light stimulus. Photoacids based on spriopyran may be directly incorporated into molecular and supramolecular systems for applications in stimulus-responsible switching with applications ranging from synthetic catalysis to in-situ drug release. New photoacidic molecules are required which are suitable for building into larger structures and membranes, and the tuning their photoswitching properties will be studied using a combination of spectroscopic techniques.

Skills: organic synthesis, multidimensional NMR spectrometry, mass spectrometry

N O

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(c) Novel ruthenium(II) complexes

Ruthenium(II) complexes are extremely useful complexes with applications ranging from energy storage and light harvesting, to catalysis and drug applications. This project will develop new types of chiral ruthenium(II) complexes which are responsive to their environments to allow these useful properties to be controlled by external stimuli (eg, temperature, chemical reagents, light, redox etc).

Skills: organic and inorganic synthesis, multidimensional NMR spectrometry, mass spectrometry, X-ray crystallography, cyclic voltammetry, X-ray crystallography, photophysical measurements

(d) Molecular rotors

(in collaboration with A/Prof. Jason Harper)

Being able to control motion at the molecular level is a fundamental challenge facing science. Nature uses controlled molecular motion, so called ‘molecular machines’ to control virtually every process in biology. So far, chemists use molecular machines to control nothing! This project involves the synthesis of molecular ‘rotors’ with a ‘propeller’ which can spin spontaneously when appropriate energy is supplied.

Skills: Organic synthesis, multidimensional NMR spectrometry

(e) …or other projects tailored to your interests!

1. Yang, J.; Bhadbhade, M.; Donald, W. A.; Iranmanesh, H.; Moore, E. G.; Yan, H.; Beves, J. E. Chem. Commun. 2015, 51, 4465-4468.

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17

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ustering of et al.[1]

18

breast cancer cell lines. The project will make use of new methods for oxygen tolerant polymer synthesis on microtitre plates that we have recently developed in order to prepare these libraries at low volume and high throughput.[2]

The project will involve the synthesis of several chain transfer agents required to generate the different polymer architectures, the synthesis of peptides for receptor binding, and subsequent polymerisation and polymer analysis by NMR, GPC and associated techniques. Screening of biological activity will be performed in collaboration with Dr Adam Gormley at Rutgers University in the USA, and there is the possibility of visiting his lab in the middle of the year to perform some of this work if you so choose.

(b) Stabilisation of glucose oxidase enzymes in nanocapsules (with Prof. Martina Stenzel)

Despite their extensive use in a range of synthetic, biosensing, and therapeutic applications, enzymes are often highly unstable to heat, pH, and the presence of organic solvents. However, several recent studies have shown that it is possible to protect enzymes against degredation by such environmental factors by encapsulating them within nanocapsules.[3,4]

We recently developed a new methodology for encapsulation of glucose oxidase (GOx) inside a type of nanoparticle known as a polyion complex (PIC) micelle. This gives excellent control over the structure of the nanoparticle, and allows us to crosslink the shell surrounding the enzyme to impart mechanical stability to the enzyme. In this project we will incorporate sugars such as trehalose, mannose, glucose and fructose, which have been shown to have a stabilising effect on enzymes,[3] into our enzyme nanoparticles and compare their effects on enzyme stability. This will be done by first polymerising the sugars into the polymer backbone and then assembling them into the core of the PIC micelle. Enzyme activity will be monitored after exposure to a range of solvent, thermal, and other environmental stresses.

The project will involve controlled polymer synthesis and self-assembly techniques to prepare the enzyme nanocapsules, characterisation by light scattering and electron microscopy, and the use of enzyme activity assays to measure their activity under a range of environmental stresses.

1) J. Lemke, S. von Karstedt, J. Zinngrebe and H. Walczak, Cell Death Differ., 2014, 21, 1350–64.

2) R. Chapman, A. J. Gormley, M. H. Stenzel and M. M. Stevens, Angew. Chemie Int. Ed., 2016, 128, 4576–4579; R. Chapman, A. J. Gormley, K. Herpoldt and M. M. Stevens, Macromolecules, 2014, 47, 8541–8547.

3) A. Beloqui, S. Baur, V. Trouillet, A. Welle, J. Madsen, M. Bastmeyer, G. Delaittre; Small, 2016, 12, 1716–1722

4) E. M. Pelegri-O’Day, S. J. Paluck and H. D. Maynard, J. Am. Chem. Soc., 2017, 139, 1145-1154; R. J. Mancini, J. Lee and H. D. Maynard, J. Am. Chem. Soc., 2012, 134, 8474–9.

Preparation of single enzyme nanogels. Adapted from Beloqui et al [3]

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20

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21

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23

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24

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FIELD ng (F10) w.edu.au

MISTRY

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25

Alternative Bridging Groups for Organometallic Polymers

The majority of alkyne-bridged organometallic polymers use linear aromatic spacer units, such as 1,4-diethynylbenzene, as the bridge between metal centres. Non-aromatic bridges such as 1,12-diethynyl-p-carborane (C6H12B10) have been described as “3D aromatic systems”. We are interested in the effect of aromatic bridges, as well as non-aromatic bridges such as 1,3-diethynylbenzene, on the chemical and electrochemical behaviour of organometallic polymers.

(b) The Organometallic Chemistry of Carbon Dioxide

Carbon dioxide reacts with many organometallic compounds to give products in which the CO2 is incorporated into the metal complex. A greater understanding of the ways in which CO2 binds and reacts with metal compounds may provide new ways to capture CO2 and utilise this wasted and environmentally dangerous compound.

Our previous work has focused on the stoichiometric insertion of CO2 into metal-hydride and metal-carbon bonds, to give metal formates and acetates, respectively. There have been many reports in the literature of catalytic activation of CO2 to yield formic acid (by hydrogenation), acrylates (by reaction of CO2 with ethylene), and carbonates (by reaction of CO2 with epoxides). We are interested in exploring the ability of novel iron(II) and ruthenium(II) complexes that we have prepared in the lab to catalytically activate CO2.

(c) The Chemistry of ‘CP3’ Complexes

We have recently developed a new type of polydentate ligand for transition metals, which binds to metal centres using three phosphorus donors and an anionic carbon donor. To date, we have only explored the chemistry of this ligand on ruthenium(II). We anticipate that this ligand will form complexes with a wide range of transition metals, and are particularly interested in investigating the synthesis and catalytic properties of new rhodium and iridium complexes.

Selected publications from the group:

1. L. D. Field, A. M. Magill, T. K. Shearer, S. J. Dalgarno, M. M. Bhadbhade, Eur. J. Inorg. Chem., 2011, 23, 3503-3510.

2. L. D. Field, P. M. Jurd, A. M. Magill, M. M. Bhadbhade, Organometallics, 2013, 32, 636-642.

3. O. R. Allen, L. D. Field, A. M. Magill, K. Q. Voung, M. M. Bhadbhade, S. J. Dalgarno, Organometallics, 2011, 30, 6433-6440.

4. L. D. Field N. Hazari, H. L. Li, Inorg. Chem., 2015, 54, 4768-4776.

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27

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t-activated elecamatically impro

wish, S. Ciampi,atures”. Submi

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28

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29

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30

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31

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ionic liquies, UNSW; P

& Prof. Bill P

dynamics sim; this can be eed faster othis and to mhich ionic liquto do this b

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34

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s within the

eptides nds for the nd malaria. des: (i) their (ii) it is difficu

se their targeistry to solvesise stereosable shape-c

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s other proteines are involvg cancer, mag targets. Inaspartic prote atoms into

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ming Ho

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s, fluorine bility, 3D

variety of s of the

Pasquier,

(c) Stroke isand thepursuingactivate (a kind nerve ceis a monaturally

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(d) Gamma-bad reputhe braina variedepresssedativea “date-variety moleculebind to mproject, the desir

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All of themajor exneuropro

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ells into damaolecular-leve

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rator: Dr Nico

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e/hypnotic ac-rape” drug.of GHB’s

e’s conformamany differenwe are creatrable activity

rator: Prof Ma

Molecular Vunprecedenis a commo

Chemotherapyffectiveness to many cobind to DNA

ult for tumouwith a slowe

rators: Dr Gra

e above projexperimental totection assa

novel treatmcause of deatoptions are pproach. We natural hypoitude-chambeage-control mel understans hypoxia res

ole Jones, A/

undesirableyrate (GHB)nds to neuro previously b

ments incluunately howctivity, which We believeeffects can ational flexibnt neurotransting conform while editing

ary Collins, D

Velcro: creatnted ways n disease thy is the princ is limited bynventional d

A and weld thr cells to repr developme

aham Ball, A

ects (and othtechnique. Otays; solid-pha

ment for stroth and disabiextremely li

e’re developoxia protectiver-in-a-pill”), mode after a nding of thesponse.

/Prof Renate

e activity out is a molec

otransmitter rbeen prescribding alcoho

wever, GHB has led to ite that the be attribut

bility, which asmitter recepationally-rest

g out the und

Dr Junming H

ting new mo

hat kills 1 in cipal treatme the resistanrugs. We are

he two strandpair. This wilnt of drug res

A/Prof Larry W

hers within thther techniquase peptide s

35

oke ility in Austraimited. We

ping drugs tve mechanis which will stroke. The e proteins t

Griffith

t of illegal dcule with a receptors in bed to treat olism and also has ts abuse as bewildering ted to the allows it to

ptors. In this tricted fluorin

desirable acti

Ho

olecules that

3 of us in tent for metasnce that tumoe developingds together inll give potensistance.

Wakelin

he group) areues that you synthesis; an

alia, are that sms put key that

rugs

nated analogvity.

t will stick to

the Western tatic cancer,

our cells can g new drugs n a way that

nt anticancer

e based on smight use in

nd DNA-bind

gues of GHB

o DNA and c

synthetic orgaclude: molecing biochemi

, in order to

crosslink it i

anic chemistcular modellinical assays.

preserve

in

try as the ng; NMR;

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laser spectrcover new chtribute to inte

d be great to

Weird chemh Jordan, Sy

he 1930’s, thWhen the acnsuspected pd new chemi

oaming” reactnough energyforming unexs and to exp

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n 104 and 10developing a to understanredict the im

gen (H2) in ration of aro(half-life ~

y unimporta for observed

ssing source ty that H2 wre already H2

atmospherends to theons, has hahe ozone h

oscopy to chhemical reacternational atm

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mistry – reydney Univ.

e concept octivation eneprocesses becal pathways

tion: When ay to escape xpected prodlore whether

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the atmosphound 500 pa

2 years), int. Howeverd amount of of H2 that is

will find broa2 cars) meane is likely. e atmosphead severe cohole and gl

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haracterise neion mechanismospheric m

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ompounds htmospheric m chemical spreleasing new

here is a trarts per billiot has been r, atmosphe H2. Modelers photochemd application

ns that large-Mankind’s r

ere, withouonsequencesobal warmin

36

LASER PR

ew free radicsms that can

models to test

udents on th

at just don’

n state (TS) near the TS etitive, even iously describ

initiated neas influence. Hroject will seeproducts play

ators: Merel Labs, USA

have been mmodels very pecies on airw compound

ace species on. As a lon considered

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measured in challenging.r quality, ozos. Two proje

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at there re. The en fuel” ge of H2 eleasing nd the st (think ave the

PROF. SCLevel 1, Da85 4713 E: s

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ained by curreed atmospher

projects:

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, Sydney Usen, UNSW)

the atmosph But such mne depletioncts are offere

COTT KAlton Buildin

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ent theories; ric processes

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of chemicalcomes very st few years

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ABLE ng (F12) w.edu.au

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H-atom aromaticcustom-combust

nity to correcresearch, weet light. In thes and workrs is also a po

e of fluorinatee alternativesund widespreave a differened atmosphels thousandshere in the 19re work is urge atmosphereent, or tailore

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and H2O) og the volatilityformation. T

c emissionsogenic emissunknown. Thfor 2019, for

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assumed initia

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ct the weakne have discohis Honours pk out the chossibility.

ed compounds to the chloroead use in cont environme

eric lifetimes rs of times gre990s and willgently needee. This projeced to be almo

the atmosp

key intermedreactions. O

ep in the “proospheric ceduce the fully oxidize

or increase y and leading

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r example:

attack on atmtracting H tohe OH-adduestigate eithohexene) anm and probed electronic sal step in atm

s from commoth cases mar to make itmass selecte

nesses in atmovered that project, you wemical mech

ds (collaboratofluorocarbonommercial proental drawbacranging from

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ct can be tailoost exclusive

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molecular ed products the MW, g to harmful ng of either rpenes) or toluenes) is eral projects

mospheric spo form H2O acted radicals

her a typicad react it witd using laserstructure of t

mospheric pro

on fuels andaking radicalt gain or lod and probed

37

mospheric chmany carbowill make mehanism and

tion with Chrins (CFCs) anoducts, but wck: they abso

m decades to rbon dioxide

r centuries. Tand the pathwored to have

ely experimen

ombustion (C

pecies: OH and a radicas have beenl biogenic cth OH. The er spectroscopthe radical processing of t

d biofuels: Hs. In this pr

ose H. Thed by laser sp

hemistry of Honyls are a easurementsimportance.

ris Hansen): Hnd hydrochlowith no ozoneorb infrared licenturies. Th (CO2). Thes

Their atmosphways by whic a significant ntal in nature

Collaborator

can attack l, or adding n scarcely mcompound (eensuing OH-apy to determroduct. This wthese compo

Hydrogen atoroject you we resulting pectroscopy.

H2 before wesource of H

s of H2 produ Collaborat

Hydrofluorocorofluorocarboe depletion poght very strohis leads to gse compoundheric chemistch these spe computation, or anywher

r: Tim Schm

unsaturated across a -b

measured in e.g. -pinenadducted or aine where thwill provide tunds.

ms can be loill choose suradical, the

e reach this H2 when expuction from a tion with atm

carbons (HFCons (HCFCsotential. How

ongly, and haglobal warminds began entetry is not und

ecies are remnal chemistryre in between

midt)

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BIOI

Inspired chemistrof our wchemicaand biolcellular i1) Dev2) Use

syntOur worchemistr It wouldprojects

(a) J. Kruzic

Hydrogeremodeldynamicof stimulare inveresponseforce. WchemistrRecentlyhydrogeHorizonsconjugatand chelinkages

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3D printformulatprolongeobserved

INSPIRED

by biologicary to mimic th

work is motival cues (extraogical cues dentity, fate elop model s the output frthetic organork is necessary, materials

d be great tos:

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els in tissue led, and und

c chemistry inli-responsive

estigating chee to stimuli iWe are parry can be moy, we demonl facilitated rs 2016). Thistion tag, and emistry of ss that we are

Directing therials (w/ Pro

ing of cells ation, segregaed printing, d in nature.

D MATERI

al materials, he physical avated by a dacellular matr(paracrine anand function

synthetic platrom 1 to des

oids, model tuarily interdisc fabrication (b

o work with

hemical funcg.)

are viscoeladergo dynamn the laborat

e motifs, or seemical linkagncluding: temrticularly intodulated thronstrated howreaction withs approach represents asoft material interested in

he chemistrof. J. Gooding

and tissues iation of diff

and difficu New metho

ALS, TISS

we integrateand chemicadynamic modrix compositiond juxtacrine. Our broad atforms for celign clinically umours, tissuciplinary; honbioprinting, li

Honours stu

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ry/architectug)

s limited by ferent cell tulty recreatindologies to q

38

SUE ENGI

e nano- andl properties o

del of the mion), physica

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udents on th

n of hydrog

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LT: 9385 46

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d micro- fabrof the cell anicroenvironml cues (geomides mechan

earch and himaterials tha

d replacemennts will gain and cell and

he following

gels (w/ Prof

continuouslyy. Recreatingincorporationroutines. Wee dynamic inc activity and where the

on or tensionture in a dis

or molecule wng virtually a the mechaniother dynam

extruded so

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poly(ethylenaterial (Fig. with the ap

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KILIAN ng (E10) .edu.au

MISTRY

synthetic ent. Much between

pography) influence

elopment. ome (e.g.

synthetic ques.

ne glycol) 1; Mater.

ppropriate

tures disulfides h acceptor

ll-laden chemicv. Mater., 2015)

for

cally )

tissue sttissue ecomposimicrofluico-culturwithin a

(c)

Cells inphysiolomechanmicroenvdevelopereversibmechanEnabledduring oAdv. Hesimple pdirectionwith revnanoparmicroenv

(d) Stenzel)

Our inteprogresstumour colonizahydrogeof thesestate (Ficells arecauses oof our therapeuin need exploringcell typeJunmin Lee, Mer

Joshua M. Grolm

Amr A. Abdeen, (19), 2536-2544.

Junmin Lee, Am

tructures witengineering. ition (Fig. 2;idics will be ere formulatio3D bulk poly

Magnetoact

n vivo interogical and ics and mvironments ed a compoly modulatedics—to stud by the dyn

osteogenesisealth. Mater. permanent mns in this proversible bonrticles withinvironment fo

Synthetic tu

erests in cesion and me

microenviroation. We mils and were a

e micro-tumoigure 4; Natue believed toof suffering in

model sysutic developmof students g spatiotemp

es. redith N. Silberstein, Amr

man, Douglas Zhang, And

Junmin Lee, N. Ashwin B.

r A. Abdeen, Kathryn L. W

h well-defineWe are exp Advanced Memployed to

ons for transly(ethylene gly

tive hydroge

ract with mpathologica

matrix presin the labor

osite magnetod across thedy temporal amic reversi where stiffe 2016). Thesagnets, whic

oject involvesnds (e.g. H-n the hydror therapeutic

umours for c

ellular “plastietastasis is onment thaicroengineereable to uncovrs in orchest

ure Materials be the root n cancer. Oustems into ment on patieincluding: neporal uptake

r A. Abdeen, Sang Yup K

drew M. Smith, Jeffrey S.

Bharadwaj, Randy H. Ew

Wycislo, Timothy M. Fan,

ed segregateploring the eMaterials 20 establish graation to a 3D

ycol) hydroge

els to drive c

matrices thatal processesentation. Hatory has poactive mate

e full spectrurelationship

bility, we disening guides se materials

ch will broades: 1) the inve-bonding in gel framewo

c developmen

cancer nano

city” has lea conseque

at promote ed small pover an intrigutrating the ac 2016). This cause of rec

ur vision for thautonomous

ent derived cew hydrogel of nanopart

im, and Kristopher A. Kili

Moore, and Kristopher A

woldt, and Kristopher A. K

and Kristopher A. Kilian,

39

ed populationextrusion of m015). By incoadients of mD printer to el.

cell and tiss

t are dynaes governedHowever, rproved challeerial—where um of physios in cell-mascovered crit lineage spe can be ada

en the use ofestigation of

polysacchaork, and 3)nt.

omedicine d

ed us to caence of dyn intravasatiopulations ofuing role for gctivation of a is importantcurrence andhe future of ts tissue-mimcells. We havchemistry anticles, integra

ian, Mechanochemical fu

A. Kilian, Rapid 3D extrus

Kilian, Magnetoactive hyd

, Interfacial geometry dict

ns has the pmultiple hydorporating chultiple cell bidirect write t

sue engineer

amic, with md by chanrecreating tenging. We stiffness ca

ologically releatrix interacttical time pe

ecification (Fapted to muf this techniqustiffening anrides), 2) c) establishin

development

ncer, wherenamic interacon, extravaf melanoma geometry at ta cancer stet because thed metastasisthis work is thmetic architve several nend fabricationation of mult

nctionalization of disulfide

ion of synthetic tumor mic

rogels for temporal modu

tates cancer cell tumorige

potential to brogel materia

hemical handnding ligandsthe cell-laden

ring

many nging these have

an be evant tions.

eriods ig. 3; ltiple hydrogue to virtually

nd softening covalent tethg a 3D ma

t (w/ Prof. M

e we believections in theasation andcells across

the perimetem cell (CSCese CSC-like

s, the primaryhe integrationtectures, foew directionsn techniquestiple differen

e linked hydrogels, Mater

croenvironments, Advanc

ulation of stem cell activity

enicity, Nature Materials,

Fig. iron Hea

be transformaals of tissuedles in the ps. We aim ton extruded h

gel systems, y any laboratin hydrogel

hering of iroagnetoactive

M.

e e d s

er C) e y n

or s s, nt

rials Horizons, 2016, 3, 44

ced Materials, 2015, 27 (3

ty, Advanced Healthcare

2016, 15, 856-862.

3. Cancer cell particles in a h

alth. Mater., 201

Fig. 4. Incurvaturethe activstem-likeMater., 2

ational to e-mimetic polymers, o develop hydrogels

and use tory. New materials on oxide e tumour

47-451

37), 5512-5517

Materials, 2016, 5

adherent to hydrogel (Adv. 16)

nterfacial e will guide ation of a

e state (Nat. 2016)

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I am opsystem. principleexpectin

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Tarascon J.-M. Building b

Aurbach D. Promise and

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better batteries. Nature 4

reality of post-lithium-ion

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s a promisigh theoreticadue to the for processes. as encapsul

ughout the ba

inger Science & Business

51, 652–657 (2008).

batteries with high energ

um batteries. Adv. Mater.

able batteries. J. Am. Ch

g of li–s rechargeable bat

41

ed rechargeascale energy

cific capacity es. (c) Electr reduced to itated by the a

minium comple

tion with Prof

ng high-peral specific crmation of so In this projlates sulphurattery cycling

s Media, 2008.

gy densities. Nat. Rev. Ma

28, 7564–7579 (2016).

hem. Soc. 139, 6635–664

tteries. Adv. Mater. 25, 65

able AI-ion bay storage app

of Li-ion anrochemical res semiquinon

asymmetric cleex.

f. Do Kyung

rformance bapacity.6 Ho

oluble polysuject, we willr within the e

g process.

ater. 1, 16013 (2016).

3 (2017).

547-6553 (2013).

atteries couldplications.

d Al-ion battedox of quinoe state. Followeavage of dia

Kim at KAIST

attery candiowever, it ha

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d provide a p

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timicrobial di Prof. David

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42

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45

(c) Have your own idea(s)?

If you have your own idea for a project that aligns with our philosophy then we would like to hear from you. Get in contact with me and we can discuss your project idea(s).

References

1. M. M. Cooper and R. L. Stowe, “Chemistry Education Research—From Personal Empiricism to Evidence, Theory, and Informed Practice,” Chem. Rev., vol. 118, no. 12, pp. 6053–6087, 2018.

2. N. Reid, “A scientific approach to the teaching of chemistry. What do we know about how students learn in the sciences, and how can we make our teaching match this to maximise performance?,” Chem. Educ. Res. Pract, vol. 9, no. 1, pp. 51–59, 2008.

3. V. Talanquer and J. Pollard, “Let’s teach how we think instead of what we know,” Chem. Educ. Res. Pract., vol. 11, no. 2, pp. 74–83, 2010.

4. M. K. Seery, “Harnessing technology in chemistry education,” New Directions in the Teaching of Physical Sciences, vol. 0, no. 9, pp. 77–86, 2013.

5. “New app a game changer for chemistry education - RMIT University.” [Online]. Available: https://www.rmit.edu.au/news/all-news/2017/jun/new-app-a-game-changer-for-chemistry-education. [Accessed: 21-Aug-2018].

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49

would learn how to synthesize molecules, and multiple techniques including how to run reactions in solution and on solid phase. In this project you would learn how to synthesize molecules utilizing solution and solid phase chemistry. You will learn how to run proton and 2-D NMR, LCMS, and column chromatography. You will also have the opportunity to learn how biological assays work on your compounds, including cell death, cell permeability, protein level analysis via western blots, protein folding assays, and protein expression.

(c) Developing prodrugs: a general approach for building cell permeable drug molecules

This project will involve the synthesis of prodrugs that can enter cells and where masking groups are cleaved in cell lysate revealing the active molecule. The approach for this project will involve the incorporation of masking polar side chains with methyl groups, which are easily removed upon cell entry via enzymes. Prodrugs will also incorporate N-methyls on the backbone amide bonds and D-amino acids, both modifications disrupt intramolecular hydrogen bonds within a macrocycle and change the orientation of the side chains in such a way as to improve cell permeability. The prodrug molecules will also include asparagines, where these side chain amides increase transport across the cell membrane. In this project you would learn how to synthesize molecules utilizing solution and solid phase chemistry. You will learn how to run proton and 2-D NMR, LCMS, and column chromatography. You will also have the opportunity to learn how biological assays work on your compounds, including cell death, cell permeability, protein level analysis via western blots, protein folding assays, and protein expression.

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52

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NAL CHEM

therapeutic afocus of Profgents. as such, thete analogs t

of collaboratiding the biolo

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MISTRY

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53

mediate the phosphorylation. This work originated from earlier work on the synthesis of a natural product. Variolin B is a member of a unique class of marine alkaloids isolated from an extremely rare Antarctic sponge. It is no longer available from its natural source. The Morris group have devised a synthesis of variolin B that has restored access to the material and allowed further biological studies to be carried out. From this work it has been established that variolin B is a potent kinase inhibitor and represents an important scaffold for the development of kinase inhibitors. A range of analogs have been developed that are more selective inhibitors of certain kinases, as well as have better properties (such as solubility).

Our recent publication (ACS Chem. Biol., 2017, 12, 825) describes how we have developed a new class of kinases inhibitor that selectively inhibits the kinase SRPK1 and has led to the identification of a series of molecules that are currently being developed as a treatment for aged macular degeneration, in collaboration with Exonate.

The Morris group is focused on developing selective inhibitors of the various RNA slicing kinases (the CLKs, DYRKs and SRPKs), with appropriate drug-like properties so they can be used as chemical probes to help understand the role these important kinases have on biological systems. A combination of synthesis and structure-based drug design is used to do this work, with students able to use Schrodinger and Cresset software to aid their design work.

(c) Developing the AAL(S) Scaffold for Therapeutic Applications (collaborations with Assoc Prof Nigel Turner (SOMS), Prof Alaina Ammitt (UTS), Dr Nikki Verrills/Dr Matt Dun (Newcastle)

Ceramide synthase (CerS) and protein phosphatase 2A (PP2A) are two enzymes that play a critical role in the regulation of multiple cellular signalling processes. The malfunctioning of these two enzymes has been found to have implications in diseases such as cancer, diabetes, asthma and neurological diseases including Alzheimer’s disease and stroke. Little is known about the biological mechanism of these enzymes and in particular, how they cause such diseases. To gain insight into these biological processes, the CerS and PP2A binders, FTY720 and AAL(S), will be used to explore the binding site of both enzymes and allow the identification of chemical probes which can be used to develop an understanding of the biological mechanisms of these complex diseases.

Development of the AAL(S) scaffold will allow for analog production which along with key biological testing will provide key information towards revealing the biochemical pathways and proteins involved regulating both enzymes at a molecular level. With Prof Ammitt, work is focused on using these molecules for the development of therapeutics for the treatment of asthma, whereas with Asoc Prof Turner we are developing molecules to elucidate the role of CerS in fat metabolism (see Turner et al, Nature Communications, 2018, 9: 3165 | DOI: 10.1038/s41467-018-05613-7)

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54

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LEX CHEM

explore andon a type of mcan be acces is accompation in data

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s and have umetal ions cace switching c measuremenctional coo

VILLE ng (F12) w.edu.au

MISTRY

develop molecular essed by anied by storage,

ANSTO)

uses in a apable of

between ents and

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c materials cystals of cooThe overall re the use onimal defectsnd various ma

55

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of microfluidics. In this projagnetic and s

molecular buicks (metals ae on includinemperature, state (aka be

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lding block aand ligands) ng d4-7 transitpressure and

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approach (“mto form, for tion metal iod light-irradiaals!).

hniques. Thiolecules whxtremely sennanocrystals a range of X

molecular example, ns which ation and

s project ich show nsitive to s that are X-ray and

Nguyen’systems

(a) TropyliumRecent sunderstochemistrcan be umaterialsencoura

(b) Recentlyreaction produceseries o

s group hass or unusual m

Project NTVm ion is an usynthetic advood, allowingry[2-5] and phused as a ves for metal ged to discus

Project NTVy, N-Heteroc promoters d from com

of active agro

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s several Homolecules an

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V2 - N-Heterocyclic Olefins

with interesmercially avochemicals

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um Ion as Ch-benzenoid aour group ha start to utiliy. This projecmophore for nsing. As soin person ab

ocyclic Olefs (NHOs, sesting action vailable precuin the 1970s

56

CATALYS

cts focusing ns of those in

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VINH NGUlton Buildin

nguyen@unsw

RY OF UNUMOLEC

novel organoistry.

arbon-ring strmore accessns in organoindings that dyes and lumfidential, stud

ew class of can be conginally targe far more in

UYEN ng (F12) w.edu.au

USUAL CULES

ocatalytic

ructure.[1] sible and ocatalytic tropylium

minescent dents are

valuable veniently ted as a

nteresting

57

compound family. Due to the donating ability of the two nitrogen atoms, the exocyclic C-C double bond is very electron-rich and strongly polarized. This interesting feature of NHOs offers multinucleophilic reactivity over the ketene aminal frameworks.[6] Due to the strong nucleophilicity of the -carbon, NHOs can act as strong Lewis/Bronsted bases.[7-9] This project will focus on synthesizing a family of NHOs, estimating their basicity and applying them as organocatalysts to promote environmentally friendly chemical processes. Students are encouraged to discuss with Vinh in person about this project.

(c) Project NTV3 - Tropylium-Based Host-Guest (collaboration with A/Prof Pall Thordarson) This project will explore the potential of tropylium-bearing systems in host-guest chemistry in collaboration with A/ProfPall Thordarson’s group. The electron-deficient nature of tropylium moiety makes it particularly attractive for the binding and sensing of small and medium-sized biologically importantanions such as chloride, phosphate and carbonates. Wepropose the synthesis of tropylium-based macrocycles (see figure) as the starting point for this project, which will representa new platform in supramolecular chemistry. Please also see Thordarson’s Honours projects for more details.

References [1] D. J. M. Lyons, R. D. Crocker, M. Blümel, T. V. Nguyen,* Angew. Chem. Int. Ed. 2017, 56, 1466-1484. http://dx.doi.org/10.1002/anie.201605979

[2] T. V. Nguyen,* A. Bekensir, Org. Lett. 2014, 16, 1720-1723. http://dx.doi.org/10.1021/ol5003972 [3] T. V. Nguyen,* M. Hall, Tetrahedron Lett. 2014, 55, 6895-6898. http://dx.doi.org/10.1016/j.tetlet.2014.10.100 [4] T. V. Nguyen,* D. J. M. Lyons, Chem. Commun. 2015, 51, 3131-3134. http://dx.doi.org/10.1039/C4CC09539A

[5] Demelza J. M. Lyons, Reece D. Crocker, Dieter Enders, Thanh V. Nguyen,* Green Chem. 2017, in press (DOI = 10.1039/C7GC01519D). http://dx.doi.org/10.1039/C7GC01519D

[6] R. D. Crocker, T. V. Nguyen,* Chem. Eur. J. 2016, 22, 2208-2213. http://dx.doi.org/10.1002/chem.201503575

[7] M. Blümel, J.-M. Noy, D. Enders, M. H. Stenzel, T. V. Nguyen,* Org. Lett. 2016, 18, 2208-2211.

http://dx.doi.org/10.1021/acs.orglett.6b00835

[8] M. Blümel, R. D. Crocker, J. B. Harper, D.Enders, T. V. Nguyen,* Chem. Commun. 2016, 52, 7958-7961.

http://dx.doi.org/10.1039/c6cc03771b

[9] Ugur Kaya, Uyen P. N. Tran, Dieter Enders, Junming Ho, Thanh V. Nguyen,* Org. Lett. 2017, 19, 1398–1401. http://dx.doi.org/10.1021/acs.orglett.7b00306

N

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(NHOs)

N

N

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very strongLewis/Bronsted base

positive chargestabilized by aromaticity

NHOs = NOVEL CATALYSTSon organocatalytic chemistry

Potential guests: Cl, HnPO4(3-n),

ArCO2, ArSO3, ArPO32

-electron poor cavity (binds anions)

aniontropylium

Rob Dev Dete Accu Dire

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Understarealizingmoleculamass spenzyme-

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ch Interests

anding the ing the bottom-ar units in ispectrometers-like molecul

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58

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. RIJS ng (F12) w.edu.au

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59

Unique techniques used in the group include:

-advanced mass spectrometry and ion-mobility mass spectrometry,

-robotic analysis of dynamic combinatorial solutions, with screening of large chemical data sets,

-electronic structure and trajectory methods of computation for structure and function,

along with a variety of kinetic, wet chemistry and chemical characterisation techniques.

Projects and collaborations include:

-Assembly and reactivity of n-confused porphyrins (P. Weis, KIT)

-Dynamic combinatorial solutions and self-assembly of bis-β-diketonates (J. Clegg, UQ)

-Unusual complexation behaviours of cyclotricatechylene clusters (B. Abrahams, UoM)

-Encapsulation of ions by cyclophanes in solution (T. Brotin, ENS Lyon)

-Effect of fluorine on catalytic and metal mediated reactions

-Development of ion mobility and mass spectrometric techniques for analysis of reaction intermediates in solution (W. A. Donald, UNSW)

Potential students are highly encouraged to discuss their research interests with Dr Rijs.

We are modificatranslatio(a) Devehard tis

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60

ATERIALSENERATIO

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61

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63

(c) Laser Spectroscopy of Isolated Radicals and Ions (with Prof. Scott Kable)

The new Molecular Photonics Laboratory houses sophisticated lasers and equipment with which we can discover new transient chemical species of importance in the gas phase chemistries of our atmosphere and the interstellar medium.

Atmospheric Radicals

One of the greatest scientific challenges of our time is to understand the complex chemistry of the atmosphere. Plants and human activity are responsible for >1000 Tg (1012 kg) of volatile organic compounds being emitted into the atmosphere each year. These molecules are processed into less volatile compounds which then find their way into secondary organic aerosols, which are a major natural impactor on public health and climate. In this project, we will develop laser-based spectroscopic methods to detect and characterize intermediates formed on the way from the plant to the aerosol particle.

Interstellar Molecules and Ions

As stars die, they eject complex organic molecules into the interstellar medium, where they live out millennia before being incorporated into new stars and planetary systems. These organic molecules are the seeds of life, but, as yet, we do not know the chemical make up of the interstellar medium from which planetary systems are formed.

Using a star as a lamp, we can peer into this medium using telescopes by observing molecular absorption spectra. However, despite there being hundreds of nibbles taken out of the visible stellar spectra of stars occluded by diffuse clouds, only a few molecules have been unambiguously detected by their visible spectra. The unidentified features are known as the diffuse interstellar bands, and are the longest standing mystery in astrophysical spectroscopy.

In this project, we will develop techniques to capture the spectra of isolated, never-seen-before aromatic cations which the leading candidates for carrying the DIBs, and (hopefully) solve this long standing problem.

(d) Advanced Spectroscopy for Complex Functional Materials (with Dr Dane McCamey, School of Physics)

Complex functional materials are employed in a range of applications, the development of which is motivated by the future technological needs of society. Organic solar cells, organic light emitting diodes and organic electronics all employ materials characterized by a complex relationship between morphology and function which can only be elucidated by advanced spectroscopic techniques.

Combining lasers and magnetic resonance, we will develop and apply new advanced spectroscopic techniques to complex functional materials, revealing the dynamical behaviour of charge carriers and excited states.

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and energyar sodium-ionharacterising

yte materials.and affo

ion battery te-scale energble power soof the followr component

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electrodes prns for lithium will be synthtery performa

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une the atomoperties suchnation of tec

diffraction (aand impedanlly characteri

cells, and the

o work with H

e next gene

s are ubiquitoe restricted

y storage of n batteries, g new e. We will wor

ordable rooto provide sgy storage frources. Stud

wing parts of in idealized

aterials

rovide the so-ion batterieshesized and ance. We areprove perform

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mic arrangemh as energy shniques to ch

at the Austnce analysis,ise materials

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ration of bat

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64

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ment (crystal storage capaharacterise otralian Sync and electron

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m into real-wowork in these

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g. mobile phications requproject will t

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R. NEERLevel 2, Da4 E: neeraj.sh

MATERIA

f solid state nductivity or , including bud ANSTO),y. orld devices se devices.

projects:

teries

hones and lauiring highertarget new b

sent the largsition metal otionship betwred electrod

be excellenterials with s

RAJ SHAlton Buildinharma@unsw

ALS CHEM

materials to thermal exput not limited solid stat

such as batte

aptop compur power, e.gbattery chem

gest cost anoxides, phospween crystal de materials

t electrolytessufficient so

ARMA ng (F12) w.edu.au

MISTRY

enhance ansion.

d to X-ray te NMR,

eries and

uters, but g. electric istries, in

d energy phates or structure

s in order

s at high odium-ion

Negative

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(b)

The majfor billiontear on b(e.g. in material costs. Innegativedue to groups o(e.g. –Ctypically voids anstates. Ssynthesicontrollavoids of in order to produ

(c) phase e

Safety isadvantagthe ionicespecialapproximconductipreventito the cproject lcharacteto study will shed

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e electrode m

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Tuning neg

ority of matens of dollars both moving optics, coat that neithern order to ae thermal exp

transverse or cooperativCN- or WO6

feature larnd cations wiSo why not s tool? In t

ably insert L the NTE mato tune the cce ZTE mate

Improving sevolution

s an importages to the hc conductivitly under am

mately 1000ivity of the eng further de

crystal structuithium-ion an

erized. Impor the formatio

d light on the

Other proje

ing on your d. Please co

materials

are the leas batteries shand underst

e next genera

ative therma

erials expand per year in parts (e.g. intings, electror expands n

achieve this, pansion (NTEvibrations o

ve rotations 6). These mrge crystalloth variable ouse a battethis project Li and Na iterials, via a

cooperative rerials.

solid-state e

ant aspect ohighly flammaties of solid-

mbient condit0C as the electrolyte. Ievelopment aures adoptednd oxide-ion rtantly, variabon (from star formation pr

cts

interests, onsult with Ne

st investigatehow poor petanding their ation of devic

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d during heatmaintenancen aircraft gasonics). If a znor contracts the oppositE) is a propeof atom of units

materials ographic xidation

ery as a we will nto the battery, otations

electrolytes

f high poweable liquid e-state compotions. At the

operating tn both examand use of thd by the eleconducting mble temperatrting reagentsrocesses and

ther solid steeraj for furth

65

ed componenerformance limitations tces.

n to produce

ting via therme, re-manufas turbines), azero thermals upon heatite extreme oerty exhibited

by underst

r batteries. Uelectrolytes thounds are g

e other extretemperatures

mples, electrhese technoloectrolytes anmaterials wilture time-ress) of these iod optimal con

tate projectsher details.

nt in a sodiumin sodium-io

towards reve

e zero therm

mal expansiocture and re

and componel expansion ing, this couof materials d by a small

anding thei

Using a solidhat are comgenerally loweme, solid os are esseolyte ionic cogies. The io

nd how they l be synthes

solved neutroonic conduct

nditions requi

, e.g. makin

m-ion batteryon batteries. ersible sodium

mal expansio

on and this pplacement co

ents that are (ZTE) mate

uld dramaticaare considegroup of ma

r formation

d-state electmercially ava

wer than thexide fuels cntially deter

conductivity ionic conducti

evolve with ized and the

on powder ditors under vared for synth

ng new supe

y and the com By developm insertion/e

on materials

process is resosts due to w designed to

erial can be ally reduce ered in this aterials predo

characteris

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eir ionic condiffraction willaried conditiohesis.

erconductors

mpounds ping new extraction

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sponsible wear and be static made, a industrial project -

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stics and

significant ortunately nterparts, perate at the ionic hurdle in ly related e. In this ductivities be used ons. This

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My worConvergis revolvmaterialson the fo

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66

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alexander.soe

d ARC Cent Gooding. Therial (both naat to work w

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ri silk fibroin

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T: +61 (0) 42

eriyadi@unsw

tre of Excehe work that atural and s

with Honours

diabetic patgy, Indonesia

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RIYADI ing (E10)

25256988

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llence in we have synthetic) students

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o have a plore the all know, tries and ry.

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2. Gil et

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netto and Kap

al., Function

en and naturEdgar Wong

ecurity is one which mean

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of this projee and the tea field trial in f

plan, New Op

nalized Silk B

re based mag, UNSW, Un

e of the grandns food produation of resouduce the bes

ct is to invesam in UGM farms such a

pportunities f

Biomaterials f

aterial (chitoniversitas Gad

d challengesuction needs urces that thet we can.

tigate the us towards fors strawberrie

67

for Ancient M

for Wound He

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s of our time. to increase be world have

se of chitosanrmulation thaes, chilies, or

Material, Scie

ealing, Adv. H

servatives fUGM), and S

World popuby 70% to be (land, financ

n as natural pat is safe, er other fruits.

ence, 2010, 3

Health. Mat.,

or fresh fooSalim Agro Gr

lation is proje compared tce, human, e

preservativesconomical, s

329, 528-533

, 2013, 2, 20

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polymers: Le

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68

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AND TAI

y packaging w 100 nm athesize varioncer drugs, w

cts starting frcancer cell li

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AFM to evalu

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for research ad number ocognition, inflens displayedlogical syste

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A PROF. L

T: 9385 4

LORED P

the drug intond can be pus polymers

while the she

rom organic sines. We hav

he following

m the succes

carriers descs. Interestnano-objectsExample is thm-like morphoups that allo In this pros that will si

understands into cells,tness as we ter. The stuate the prop

es with suga

within the f biological lammation, d by them. m, the use

apeutics for ortant step diseases.

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OLYMERS

o nanoparticprepared usi to create corll makes the

synthesis to ve meeting w

projects:

ss of viruses

cribed in litetingly, natu, viruses, h

he by now wehology. In adow fast recogoject, we wilmulate the sding of th we will ma have found

udent will theperties of the

ar antennae

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INA STElton Buildin

stenzel@unsw

S FOR CATREAT

cles. Nanopaing various re-shell nano particles so

polymer nanwith clinicians

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erature are ure’s own ave often eell-known Ebddition, virus

gnition of the ll prepare eshape of vir

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ENZEL ng (F12) w.edu.au

ANCER TMENT

rticles for materials oparticles luble and

noparticle s and we

spherical highly elongated bola virus ses carry host and elongated ruses. To of these rticles of

ould be a nd some le before

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NanoparThey cacells in influencecellular growing Howevetumour tumorigecolleaguKilian hacancer ssurfacesphenotyuptake differencto target

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various immr, these cellwhere canc

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Learning mration with Dr

lock copolym, it is wide

ate has a cortransition ber, we do noe is and howrticle. Thesehe biological cellent tools and why diffeyou would spen spend a datical mo

nse.edu.au/g

olymers has by direct RA

ese nanoparinteract with

of nanopart

uickly taken as vehicle toway. A lot

size and ohis knowledgmortal cances do not reser cells mayd in with cachool of ched a model thand cells of en geometries on of these icles by varction of nano

m cells or me

more about r Chris Garve

mers self-assely assumedre-shell strucetween bothot know whaw much watee propertiesactivity. Smathat provid

erent nanopapend some tiday at the Aodelling. Srad_students

been one ofAFT polymerrticles will bebiological me

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rious phenotoparticles andtastatic cells

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Australian SyStudents s2/honours_s

69

f our core acrization of ge loaded withedia such as

ancer stem

er cells. ugs into bout the eters on ined by the lab. found in nhanced cells. My Prof Kris to grow

morigenicity os and stars r

h nanoparticltypes simultd help us ide.

re of nanopTO

utron scatterormation. Onve differently TO and learnynchrotron inare eligibscholarships

ctivities over lycomonomeh anti-cancer proteins

cells Collabo

on an engineresulting in tes allows us

taneously. Tentify what ty

particles –

ring (SANS) nce we und and why som and apply th

n Melbourne.ble to .

the last few ers or by posr drugs and

oration with A

eered surfaceumour tissues to evaluate

This can helypes of nano

Scattering

and small aderstand theme of them dhe technique Prerequisiteapply for

years. The st-functionaliwe like to le

A/Prof Kris K

e. Cells are ge with a steme the rate olp us evaluaoparticles are

analysis at

angle X-ray se structure, do not perfore. If time pere is some inr a sc

polymers zation of

earn how

Kilian

grown on m-cell-like of cellular ating the e suitable

ANSTO

scattering we also

m. In this mits, you nterest in holarship

My groumajor chtechniqustudies ifrom simprocesse It would

(a)

Over theapproaccoordinaorderingrange of

Sorting another

This resfaced infacile stoexcellentuning theffectiveshown h

Quantum

Magneticrole to ppretty usfascinatiunderstawhen disingle cembeddideal maquantum

up focuses onhallenges fa

ues that incluis the notion

mple inter-moes in order to

d be great to

Metal organ

e last 20 yehes that hav

ation compou and immenf molecular g

and storing

search projecn industry - orage of gaset host materheir propertiee gas-selectihere.

m phenomen

c materials hplay in quantseful at secung therefor

and the behamensionalitychains (1D) ed into a no

aterials in whm confinemen

n making anacing us todaude X-ray an of hierarchicolecular inteo deliver new

o work with H

nic framewo

ears, inorganve reinvigoraunds or MOFse composituests, openi

molecules -

ct is specificeffective sepeous fuels surials for smaes MOFs canve membran

na in magneti

have revolutioum computinuring notes tre that weaviour of sucy is constrain or sheets on-magnetic ich to study t

nt.

MAT

d understanday: energy, nd neutron scal emergen

eractions; wew materials di

Honours stu

rks (MOFs):

nic chemistryated the subFs. These toional flexibiling up many

how to sele

cally targetedparations of uch as H2. Hall moleculesn become efnes such as

ic materials

onised the wng; they haveto the fridge e still do ch materials, ned. MOFs (2D) of m matrix, mathe effects of

70

TERIALS

ding new mawater and scattering in tt properties

e aim for a isplaying nov

udents on th

coordinatio

ry has takenbject – one aopologically bty, along witpotential app

ect for one m

d at very re mixed gas

Highly porouss such as CHfficient storags the H2 se

way in which e also been door. It is not fully

especially can have

metal ions king them f magnetic

A/PL

T: 938

CHEMIST

aterials that asustainabilitytruly multi-diand complexgreater und

vel properties

he following

on chemistry

n on board area showingbeautiful matth structural plications.

molecule ove

al challengestreams an

s MOFs makH4 or H2. Bge vessels oelecting MO

we store anda navigation

expe

Spin-wavusin

PROF. JLevel 1, Da85 4672 E: j

TRY AT TH

are often focy. We makesciplinary proxity - the worerstanding os.

projects:

y of the 21st

a number og particular terials displayrigidity; they

er

s d e y

or F

d use informnal aid for ce

eriment

ve spectrum ng inelastic n

JOHN STlton Buildinj.stride@unsw

HE NANOS

cused on some use of a rojects. Key rld around usof these fund

t century

of new concepromise is py intimate lo are ideal ho

mation and haenturies and

the

of a frustrateneutron scatt

TRIDE ng (F12) w.edu.au

SCALE

me of the range of to these s derives damental

epts and polymeric ng range osts for a

ave a key are even

eory

ed magnet tering

(b)

Solid stastructureorder givplay imparomaticapproximdimensiointeractiosystemscomputa

Inter-mo

IdentifiedinteractioproblemsystemsThis wormodellinof our ev

Donor-A

The inteactive chand lightinvestigaknown tomaterialsenablingrange oftremendapplicati(OLEDs)moleculehighly instacking

(c)

Other pspectrospossible

Order and d

ate materialses; however ves way to dportant roles cs, are omating to onality direcons and or

s to studyational simula

olecular hydro

d by Linus Pons, the bass to study wh

s, making userk is highly co

ng - it is idealvery day life.

Acceptor stac

ermolecular inharge transfet emitting dioate the interao contribute s can be

g uniaxial cof suitable D aous promiseons, whethe) or broad-raes, they are nformative in interactions

Other proje

rojects involscopy are ave research pro

disorder in m

s are often what occurs isorder? Wein determinin

of particulaoblate d

ctly influencerientations. y; not too ations, ubiqu

ogen-bonding

Pauling arounsis of biologyhen it comese of solid staollaborative, ly to student

cks: heterojun

nteractions ber materials

odes. Complactions of si to moleculaproduced th

onduction unand A molecue in their cer it be for ange absorpt also suited

n terms of th.

cts

ving materiavailable and ojects.

molecular m

though of in upon phase

elcome to theng the behavar interest iscs, their es their inte

They are big, ameitous and ver

g

nd 80 years ay and our ws to H-bondinte NMR, X-ra requiring higts with an inq

nction photov

between effic that can acete electron imple D…A r packing. I

hat show render greater ules availablecapacity to

emission intion (OPVs). to computahe electronic

als-based ch can be tail

71

materials

n terms of te transitions we world of phviour of mole

in that reduced ermolecular

also ideal enable to ry stable.

ago, the hydwatery world. ng - we have ay and neutrgh-end reseaquisitive mind

voltaics to mo

cient electronct as organic transfers canstacks whilsIn this way, emarkable a load. Withe, these matebe tuned fo

n the visible Being relat

ational studiec interactions

hemistry, nanored to you

he long rangwhen molecuase transitiocular motifs.

rogen bond However t been lookingron diffractionarch infrastrud, seeking de

olecular mag

n donors (D)c semiconducn result in bust modifying self-healing

anisotropy, h the wide erials have or specific spectrum ively small

es that are s and -

notechnologyr interests.

(a) crystalline p

ge ordering ular ordering ns, in which Planar mole

is the champhere is a lotg at a numben and inelastcture and so

eep insights i

gnets

and acceptoctors, photovulk magnetic the periphersemi-conduc

y, graphene, Feel free to

phase

of motifs in may change entropy and ecules, such

pion of intermt to still learer of model Htic neutron sc

ophisticated ninto the fund

ors (A) yieldvoltaics, ferromaterials. Wral functionacting liquid c

, crystallograo come and

(b) plas1c phase

nto lattice e or even enthalpy as small

molecular rn and to H-bonded cattering. numerical amentals

optically oelectrics

We aim to l groups,

crystalline

aphy and d discuss

e

Lanthanknow evincrediblcycles, ldevices are explthat cou

Skills yo

It would

(a)

Recent potentiaany 3d-environmcompouprofoundthere hasynthesito exploi

ides are a cverything thely interestingluminescent or qubits in qoring the synld be used in

ou will learn:

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Organic and

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d be great to

Sterically h

insight into l ability to sy-block compment can cnds, simple d results. Altave been sesing and anait agostic hyd

S

commonly overe is to kng and have a

devices & iquantum comnthesis and cn the technolo

n of air- and m

Inorganic sy

ucidation – Neap, we grow

o work with H

indered low

stabilisation ynthesis comound. It ha

cause drastic things suchthough most

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SYNTHETI

verlooked areow and howa range of pnteresting mmputing. Thischaracterisatogy of the fut

moisture-sen

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NMR spectrow crystals)!

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-coordinate

of the mJ smpounds that

s been sugc changes h as agostict work has csting observies of new lo

actions to sta

72

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IC INORG

ea of coordiw they reactpotential app

magnetic props is where thtion of new lature.

nsitive compo

mistry

oscopy (1H,

udents on th

lanthanide

states of lan have higher

ggested that in the mag

c hydrogen centred arouvations of lowow-coordinatebilise the mJ

DRoom 113, L

T: 9385

GANIC CHECOOR

nation chemt”… This isnplications. Laperties that he research ianthanide co

ounds

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he following

compounds

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R. SCOTTLevel 1, Da5 5236 E: s.s

EMISTRY RDINATIO

istry – peopn’t so, lanthaanthanides hcould be utin the Sulway

ontaining coo

ctroscopy, S

projects:

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taining compriers to magne changes viour of lanto the meta

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e lanthanide i

T A. SULlton Buildinsulway@unsw

– LANTHON COMP

ple often sayanide compleave uses in lised in datay group comordination com

SQUID magn

pounds hintsnetic relaxatto the coornthanide coal centre caordinate comThis project compounds thions.1

LWAY ng (F12) w.edu.au

HANIDE LEXES

y “But we exes are catalytic

a storage es in, we mpounds

netometry

s at the ion than rdination ontaining an have mpounds involves hat seek

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e an interes

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73

lanthanide c

hanges aroumpound. Themore ‘exotic’ synthesisingmbination ofus to go on a

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86

JOINT PROJECTS AND COLLABORATIVE PROJECTS WITH OTHER SCHOOLS ACROSS UNSW

School of Chemistry researchers collaborate broadly with researchers in other Schools, Faculties and Institutes. If you are a Chemistry major or are eligible for Honours and wish to do a project aligned between Chemistry and another discipline, please contact the Honours coordinator.