bcvs 2016 program agenda (pdf)

National Center

7272 Greenville Avenue

Dallas, Texas 75231–4596

©2016, American Heart Association 6/16JN0525

For information on upcoming American Heart Association Scientific Conferences, visit professional.heart.org

Cardiovascular diseases and stroke afflict people of all races, ethnicities, genders, religions, ages, sexual orientations, national origins and disabilities. The American Heart Association is committed to ensuring that our workforce and volunteers reflect the world’s diverse population. We know that such diversity will enrich us with the talent, energy, perspective and inspiration we need to achieve our mission: building healthier lives, free of cardiovascular diseases and stroke.

professional.heart.org/bcvs

Sponsored and organized by the Council on Basic Cardiovascular Sciences.

Basic Cardiovascular Sciences 2016 Scientific Sessions: Pathways to Cardiovascular Therapeutics

BCVS 2016

Final ProgramJuly 18–21 | Hyatt Regency Phoenix | Phoenix, Arizona

Program at a GlanceSunday July 17

Monday July 18

Tuesday July 19

Wednesday July 20

Thursday July 21

7:00 am 7–8:00 am Continental Breakfast/Registration/Exhibits

7–8:00 am Continental Breakfast/Registration/Exhibits

7–8:00 am Continental Breakfast/Registration

8:00 am 8:00–9:50 am Session 4Mitochondrial Dynamics and Quality Control

8:00–9:30 am Session 8Organ on a Chip: iPS Cells in Disease Modeling of Cardiovascular System

8:00–9:20 am

Session 13Genomic and Epigenomic Medicine: Current Frontiers

9:00 am 9:20–9:30 am

Break

9:30 am 9:50–10:05 am

Refreshment Break/Exhibits

9:30–9:45 am


9:30–10:50 am

Session 14Systems Biology and Genetic Approaches to Novel Therapeutics

10:00 am 10:00 am Registration/Exhibits

10:05–11:55 am Session 5Novel Mediators of Cardiac Cell Death and Aging

9:45–11:55 am

Session 9Cardiac Development and Congenital Disease

10:30 am

11:00 am 11:55–12:05 pm

Special Tribute to Arnold M. Katz, MD

10:50 am–12:10 pm

Session 15Cardiac Regeneration: Bench to Bedside

NOON NOON–6:00 pm ACRE Meeting(Academy of Cardiovascular Research Excellence)

NOON–1:30 pm Early Career Workshop/Lunch 1Ticket required to attend

12:05–1:15 pm Early Career Workshop/Lunch 2Ticket required to attend

12:10 pm Adjourn

1:00 PM 1:00–1:20 pm Welcome Remarks

1:30 PM 1:20–3:10 pm Session 1Mechanisms of Cardiac Energy Production and Stimulation

1:30–3:20 pm Session 6 Non-coding and Extracellular RNAs as Modulators of Cardiovascular Disease

1:15–2:00 pm Session 10 Outstanding Early Career Investigator Finalist Competition

2:00 PM 2:00–3.50 pm Session 11Calcium Regulation in Heart Failure

3:00 PM 3:20–3:30 pm Refreshment Break/Exhibits

3:30 PM 3:10–3:55 pm Session 2 Keynote Lecture

3:30–5:20 pm Session 7 Signaling Mechanisms of Heart Function and Failure: Novel Insights

3:50–4:05 pm Refreshment Break/Exhibits

4:00 PM 3:55–4:10 pm Refreshment Break

4:05–5:55 pm Session 12 Non-conventional Players in Cardiac Healing and Regeneration4:30 PM 4:10–6:00 pm

Session 3 Exosomes, Extracellular Vesicles and Cardiovascular Function

5:00 PM

5:30 PM 5:20–6:50 pm Poster Session 2

6:00–7:30 pm Poster Session 3


6:30 PM

7:00 PM

7:30 PM 7:30–10:30 pm

Council DinnerTicket required to attend

Plenary Session

Poster Session

Meals/Breaks

Other

Legend

SAVE THE DATE!

Basic Cardiovascular Sciences Scientific Sessions 2017

July 10 –13 | Portland Executive Tower | Portland, Oregon

AHA MEMBERS SAVE UP TO $300 OFF REGISTRATION!PROFESSIONAL.HEART.ORG/BCVSSESSIONS

Life is why.Research and Patient Care are how.

The American Heart Association Professional Membership is where you’ll find the richest source of cardiovascular science and news. Enhance your knowledge, experience and networking with a membership today!

Professional Membership Benefits Include:*• Up to $400 in savings on AHA’s scientific conferences

• Unprecedented access to research and clinical information across multiple specialties

• Be a part of our AHA Professional Online Network — connect with peers and leaders in your specialty

• The research grant application fee is waived for members.

• Online access to all 11 AHA scientific journals of your choice*

• Complimentary access to Sessions OnDemandTM*

*dependent on membership tier

Learn about the benefits of professional membership and join our network of more than 33,000 members today at professional.heart.org.

Members are where it happensJoin/Renew today!

Table of ContentsAbstracts:

Oral Abstracts ......................................................................... 23

Poster Abstracts ..................................................................... 24

Author Index ......................................................................... 148

Conference Highlights:

Awards ................................................................................... 14

Early Career Activities and Ticketed Events ............................. 13

Keynote Lecture ...................................................................... 12

New in 2016 ........................................................................... 11

Contact Information ......................................................................... 2

General Information:

CME/CE .................................................................................. 10

Learning Objectives ................................................................... 9

Registration Hours .................................................................... 9

Information for Presenters:

Abstract Presentations ............................................................ 11

Speaker Resource Room ........................................................ 11

Invited Presenters ............................................................................ 5

Letter from the Chairs ...................................................................... 3

Policy Information .......................................................................... 15

Program Agenda

Monday, July 18 ...................................................................... 16

Tuesday, July 19 ...................................................................... 17

Wednesday, July 20 ................................................................ 19

Thursday, July 21 .................................................................... 21

Program Committee ........................................................................ 4

Room Locator ................................................................................. 8

Become an AHA/ASA Professional Member and save up to $300 off next year’s registration. (professional.heart.org/membership) 2


To access a schedule of future conferences sponsored by AHA, follow these simple steps:

• From the home page, click on the “Education & Meetings” tab in the upper navigation bar.

• Select the conference you are interested in attending for more details, such as Registration & Housing, Programming, and Abstracts & Awards.

• If you have additional questions, please email us at [email protected] or call toll-free 888.242.2453

Questions and Information

QuestionsIf you have questions after reading this program, contact the American Heart Association National Center, Dallas, Texas:

Telephone 888.242.2453 (inside the United States) 214.570.5935 (outside the United States)

Fax 214.373.3406

Email [email protected]

Website professional.heart.org

Professional Membership Customer ServiceLippincott Williams & Wilkins

Telephone 800.787.8984 (inside the United States) 301.223.2307 (ooutside the United States)

Fax 301.223.2327

Email [email protected]

3Next year’s conference: July 10–13, 2017. Visit professional.heart.org/bcvssessions for more information.

Letter From the ChairsDear Colleague,

On behalf of the American Heart Association and the Scientific Council on Basic Cardiovascular Sciences, welcome to the Basic Cardiovascular Sciences 2016 Scientific Sessions: Pathways to Cardiovascular Therapeutics.

The Basic Cardiovascular Sciences conference has become the meeting of choice for investigators and trainees. It is considered by many to be the premier basic and translational cardiovascular research meeting in the world, and attracts our field’s best and brightest from across the globe.

The primary goal of this meeting is to provide a forum for timely discussion of the latest findings from leaders in the field of cardiovascular sciences. As a result, we hope the conference will foster new ideas and collaborations to accelerate translation. Attendees will hear state-of-the-art presentations on a broad array of topics, including systems biology, genetics/genomics, signaling, cardiac fibrosis and remodeling, cardiac regeneration, cell death and aging, cardiac development and congenital disease, tissue engineering, iPS cells, and cardiac cell therapy. Invited speakers represent institutions from the United States, Canada, Europe, Asia, Latin/South America and Saudi Arabia, as we further broaden our international scope and partnerships.

In addition to the Outstanding Early Career Investigator Award competition, we will have oral presentations of selected abstracts, three lively poster sessions and two lunch workshops targeting early career development. The Tuesday lunch workshop will be a networking/mentoring session where young investigators will have the opportunity to interact with faculty and members of the BCVS Leadership Committee. In the Wednesday workshop, we will feature speed networking with senior faculty panelists.

As your hosts, we hope you will find the conference an educational experience and a great opportunity to network with scientists from around the world who are dedicated to building healthier lives, free of cardiovascular diseases and stroke. Let us know if there is anything we can do to enrich your stay in Phoenix and thank you for sharing your insight and expertise. We look forward to meeting you.

Sincerely,

Raj Kishore, PhD, FAHA Program Co-Chair, BCVS 2016

Maria Kontaridis, PhD, FAHAProgram Co-Chair, BCVS 2016

Jianyi Zhang, MD, PhD, FAHAProgram Co-Chair, BCVS 2016


Basic Cardiovascular Sciences 2016 Program CommitteeRaj Kishore, PhD, FAHA, Co-Chair, Temple University, Philadelphia, PennsylvaniaMaria Kontaridis, PhD, FAHA, Co-Chair, Beth Israel Deaconess Medical Center, Boston, MassachusettsJianyi Zhang, MD, PhD, FAHA, Co-Chair, The University of Alabama at Birmingham, Birmingham, AlabamaBurns Blaxall, PhD, FAHA, Cincinnati Children's Hospital Medical Center, Cincinnati, OhioKeiichi Fukuda, MD, PhD, Keio University School of Medicine, Tokyo, JapanÅsa Gustafsson, PhD, FAHA, University of California San Diego, La Jolla, CaliforniaWalter Koch, PhD, FAHA, Temple University School of Medicine, Philadelphia, PennsylvaniaDavid J. Lefer, PhD, FAHA, Louisiana State University Health Sciences Center, New Orleans, LouisianaPhilippe Menasche, MD, PhD, Hôpital Européen Georges Pompidou, Paris, FranceSumanth Prabhu, MD, FAHA, University of Alabama at Birmingham, Birmingham, AlabamaGangjian Qin, MD, Northwestern University, Chicago, IllinoisMilica Radisic, PhD, University of Toronto, Toronto, Ontario, CanadaAnthony Rosenzweig, MD, FAHA, Beth Israel Deaconess Medical Center, Boston, MassachusettsSakthivel Sadayappan, PhD, FAHA, Loyola University Chicago, Maywood, IllinoisMark A. Sussman, PhD, FAHA, San Diego State University, Heart Institute and Integrated Regenerative Research Institute, San Diego, CaliforniaJil C. Tardiff, MD, PhD, FAHA, University of Arizona, Tucson, ArizonaTom M. Vondriska, PhD, FAHA, UCLA, Los Angeles, CaliforniaJian-an Wang, MD, PhD, No. 2 Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaRobert G. Weiss, MD, Johns Hopkins Hospital, Baltimore, MarylandJoseph C. Wu, MD, PhD, FAHA, Stanford University School of Medicine, Stanford, California

The American Heart Association gratefully acknowledges support from the following:

The Academy of Cardiovascular Research Excellence (ACRE)

Beth Israel Deaconess Medical Center Division of Cardiology

Cedars-Sinai Heart Institute

Center for Translational Medicine at Temple University

Department of Medicine, Brigham and Women’s Hospital

Novartis Pharmaceuticals Corporation

The Stanford Cardiovascular Research Institute

Second Affiliated Hospital, Zhejiang University School of Medicine

The Sussman Research Laboratory, Integrated Regenerative Research Institute at

San Diego State University

Temple University Cardiovascular Research Center

The University of Alabama at Birmingham Department of Medicine, Division of Cardiovascular Disease

Special thanks to the individual BCVS Council Members who provided funding to support this meeting

and to the following for their continued work in support of this meeting:

Junichi Sadoshima, MD, PhD, FAHA, Rutgers New Jersey Medical School

Tomomi Ide, MD, PhD, Department of Cardiovascular Medicine, Kyushu University

Shuichi Kaneko, MD, PhD, Department of Disease Control and Homeostasis Graduate School of Medical Science, Kanazawa University

Mitsuru Ohishi, MD, PhD, Cardiovascular Medicine and Hypertension, Graduate School of Medicine, Kagoshima University

Wataru Shimizu, MD, PhD, Department of Cardiovascular Medicine, Nippon Medical School

The American Heart Association is grateful to the members of the Program Committee for their dedication and leadership in planning the program.

The American Heart Association is a national voluntary health organization whose mission is:

“Building healthier lives, free of cardiovascular diseases and stroke.”


Pilar Alcaide, PhD, Tufts Medical Center, Boston, MassachusettsMark E. Anderson, MD, PhD, FAHA, Johns Hopkins University School of Medicine, Baltimore, MarylandAndrew H. Baker, MD, PhD, FAHA, University of Glasgow Institute of Cardiovascular and Medical Sciences, Glasgow, United KingdomRobert S. Balaban, PhD, National Institutes of Health/National Heart, Lung, and Blood Institute, Bethesda, MarylandBurns C. Blaxall, PhD, FAHA, Cincinnati Children's Hospital Medical Center, Cincinnati, OhioRoberto Bolli, MD, FAHA, University of Louisville, Louisville, KentuckyJoan Heller Brown, PhD, FAHA, University of California San Diego, La Jolla, CaliforniaJohn C. Burnett, Jr., MD, FAHA, Mayo Clinic, Rochester, MinnesotaHaiming Cao, PhD, National Institutes of Health/National Heart, Lung, and Blood Institute, Bethesda, MarylandJiang Chang, MD, PhD, Texas A&M Health Sciences Center, Houston, Texas Sean M. Davidson, PhD, The Hatter Cardiovascular Institute, London, United KingdomSharon K. Davis, MEd, MPA, PhD, National Human Genome Research Institute, Bethesda, MarylandGerald W. Dorn, MD, FACC, FAHA, Washington University, St Louis, MissouriJohn Elrod, PhD, Temple University, Philadelphia, PennsylvaniaThomas Eschenhagen, MD, FAHA, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyJulio C.V. Ferreira, PhD, University of Sao Paulo, Sao Paulo, BrazilAnthony B. Firulli, PhD, Indiana University, Indianapolis, IndianaÅsa Gustafsson, PhD, FAHA, University of California San Diego, La Jolla, CaliforniaJoshua Hare MD, FAHA, University of Miami, Miami, FloridaHisayuki Hashimoto, MD, PhD, UT Southwestern Medical Center, Dallas, TexasKevin E. Healy, PhD, University of California, Berkeley, Berkeley, CaliforniaJoseph A. Hill MD, PhD, FAHA, UT Southwestern Medical Center, Dallas, TexasSteven R. Houser, PhD, FAHA, Temple University School of Medicine, Philadelphia, PennsylvaniaSteven P. Jones, PhD, FAHA, FAPS, University of Louisville, Louisville, KentuckyDavid A. Kass, MD, FAHA, Johns Hopkins University, Baltimore, MarylandDaniel P. Kelly, MD, FAHA, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, FloridaMohsin Khan, PhD, Temple University, Philadelphia, PennsylvaniaIl-man Kim, PhD, Augusta University, Augusta, Georgia Lorrie A. Kirshenbaum, PhD, FAHA, St. Boniface Hospital Research Center, Winnipeg, Manitoba, CanadaBjorn Knollmann, MD, PhD, FAHA, Vanderbilt University, Nashville, TennesseeBrian K. Kobilka, MD, Stanford University School of Medicine, Stanford, CaliforniaWalter J. Koch, PhD, FAHA, Temple University School of Medicine, Philadelphia, PennsylvaniaRichard Lee, MD, FAHA, Brigham and Women's Hospital, Boston, MassachusettsDavid J. Lefer, PhD, FAHA, LSU Health Sciences Center, New Orleans, LouisianaE. Douglas Lewandowski, PhD, FAHA, Stanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, FloridaQiangrong Liang, MD, PhD, New York Institute of Technology, Old Westbury, New YorkRonglih Liao, PhD, FAHA, Brigham and Women’s Hospital and Harvard Medical School, Boston, MassachusettsJoy Lincoln, PhD, Nationwide Children's Hospital, Columbus, OhioEduardo Marban, MD, PhD, FAHA, Cedars-Sinai Heart Institute, Los Angeles, CaliforniaTimothy McKinsey, PhD, University of Colorado, Aurora, Colorado Elizabeth McNally, MD, PhD, University of Chicago, Chicago, IllinoisJeffery D. Molkentin, PhD, Children's Hospital Medical Center, Cincinnati, OhioRusty L. Montgomery, PhD, miRagen Therapeutics, Boulder, ColoradoElizabeth (Tish) Murphy, PhD, FAHA, National Institutes of Health/National Heart, Lung, and Blood Institute, Bethesda, MarylandPeipei Ping, PhD, FAHA, David Geffen School of Medicine at UCLA, Los Angeles, CaliforniaCoralie Poizat, PhD, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi ArabiaSumanth Prabhu, MD, FAHA, University of Alabama at Birmingham, Birmingham, AlabamaWilliam T. Pu, MD, Harvard Medical School, Boston, MassachusettsNicole H. Purcell, PhD, University of California San Diego, La Jolla, CaliforniaMilica Radisic, PhD, University of Toronto, Toronto, Ontario, CanadaHoward Rockman, MD, FAHA, Duke University, Durham, North Carolina

Invited Presenters

(continued on next page)


Invited Presenters (continued)

Anthony Rosenzweig, MD, FAHA, Massachusetts General Hospital, Boston, MassachusettsSakthivel Sadayappan, PhD, FAHA, Loyola University Chicago, Maywood, IllinoisJunichi Sadoshima, MD, PhD, FAHA, Rutgers New Jersey Medical School, Newark, New JerseyJonathan Schultz, Circulation Research, American Heart Association, Baltimore, MarylandFarah Sheikh, PhD, FCVS, FAHA, University of California-San Diego, La Jolla, CaliforniaHenry M. Sucov, PhD, USC Keck School of Medicine, Los Angeles, California Mark A. Sussman, PhD, FAHA, San Diego State University, Heart Institute and Integrated Regenerative Research Institute, San Diego, CaliforniaDoris A. Taylor PhD, FAHA, Texas Heart Institute, Houston, TexasRong Tian MD, PhD, University of Washington, Seattle, WashingtonJennifer Van Eyk, PhD, FAHA, Cedar Sinai Medical Center, Los Angeles, CaliforniaJian-an Wang, MD, PhD, No.2 Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaXuejun Wang, MD, PhD, FAHA, University of South Dakota, Vermillion, South DakotaXander Wehrens, MD, PhD, FAHA, Baylor College of Medicine, Houston, TexasJoseph C. Wu, MD, PhD, FAHA, Stanford University School of Medicine Stanford, CaliforniaKatherine E. Yutzey, PhD, FAHA, Cincinnati Children’s Medical Center Cincinnati, OhioJianyi Zhang, MD, PhD, FAHA, The University of Alabama at Birmingham, Birmingham, AlabamaBin Zhou, MD, PhD, FAHA, Albert Einstein College of Medicine, Bronx, New York

Invited ModeratorsGiulio Agnetti, PhD, FAHA, Johns Hopkins University, Baltimore, MarylandMark E. Anderson, MD, PhD, FAHA, Johns Hopkins University School of Medicine, Baltimore, Maryland Zoltan P. Arany, MD, PhD, University of Pennsylvania Perelman School of Medicine, Philadelphia, PennsylvaniaBurns C. Blaxall, PhD, FAHA, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio Gianluigi Condorelli, MD, PhD, Humanitas Clinical and Research Center, Rozzano (Milan), ItalySaumya Das, MD, PhD, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MassachusettsMichael E. Davis, PhD, FAHA, Emory University School of Medicine, Atlanta, GeorgiaFederica del Monte, MD, PhD, Harvard Medical School, Boston, MassachusettsKonstantinos Drosatos, MSc, PhD, Temple University School of Medicine, Philadelphia, PennsylvaniaSarah Franklin, PhD, University of Utah, Salt Lake City, UtahÅsa Gustafsson, PhD, FAHA, University of California San Diego, La Jolla, CaliforniaJoshua Hare MD, FAHA, University of Miami, Miami, Florida Michael Kapiloff, MD, PhD, FAHA, University of Miami, Miami, FloridaRichard N. Kitsis, MD, FAHA, Albert Einstein College Medicine, Bronx, New YorkPrasanna Krishnamurthy, MVSc, PhD, FAHA, Houston Methodist Research Institute, Houston, Texas David J. Lefer, PhD, FAHA, Louisiana State University Health Sciences Center, New Orleans, LouisianaRonglih Liao, PhD, FAHA, Brigham and Women’s Hospital and Harvard Medical School, Boston, MassachusettsGangjian Qin, MD, Northwestern University, Feinberg Cardiovascular Research Institute, Chicago, IllinoisMilica Radisic, PhD, University of Toronto, Toronto, Ontario, CanadaMarcello Rota, PhD, FAHA, New York Medical College, Valhalla, New YorkSakthivel Sadayappan, PhD, FAHA, Loyola University Chicago, Maywood, IllinoisSusmita Sahoo, PhD, Mount Sinai Icahn School of Medicine, New York, New YorkIvonne H. Schulman, MD, FAHA, University of Miami School of Medicine, Miami, FloridaSusan F. Steinberg, MD, FAHA, Columbia University Medical Center, New York, New YorkMark A. Sussman, PhD, FAHA, San Diego State University, Heart Institute and Integrated Regenerative Research Institute, San Diego, California Jil C. Tardiff, MD, PhD, FAHA, University of Arizona, Tucson, ArizonaTom M. Vondriska, PhD, FAHA, UCLA, Los Angeles, CaliforniaDa-Zhi Wang, PhD, FAHA, Boston Children’s Hospital, Boston, MassachusettsYibin Wang, PhD, FAHA, David Geffen School of Medicine at UCLA, Los Angeles, CaliforniaRobert G. Weiss, MD, Johns Hopkins Hospital and University School of Medicine, Baltimore, MarylandJoseph C. Wu, MD, PhD, FAHA, Stanford University School of Medicine, Stanford, CaliforniaSean M. Wu, MD, PhD, Stanford University School of Medicine, Stanford, CaliforniaYoung-Sup Yoon, MD, PhD, FAHA, Emory University School of Medicine, Atlanta, Georgia


Abstract ReviewersThe conference organizers gratefully acknowledge the following individuals for their assistance with the abstract grading process:

Saumya Das, MD, PhD,Gerald W. Dorn, MD, FACC, FAHAKonstantinos Drosatos, MSc, PhDJohn Elrod, PhDKeiichi Fukuda, MD, PhDÅsa Gustafsson, PhD, FAHAJoseph A. Hill, MD, PhD, FAHASteven R. Houser, PhD, FAHASteven P. Jones, PhD, FAHA, FAPSMichael Kapiloff, MD, PhD, FAHAIl-man Kim, PhDLorrie A. Kirshenbaum, PhD, FAHARaj Kishore, PhD, FAHAWalter Koch, PhD, FAHAMaria Kontaridis, PhD, FAHAPrasanna Krishnamurthy, MVSc, PhD, FAHARichard Lee, MD, FAHADavid J. Lefer, PhD, FAHAAnnarosa Leri, MD, FAHAE. Douglas Lewandowski, PhD, FAHAElizabeth McNally, MD, PhDDonald R. Menick, PhDJeffery D. Molkentin, PhD

Elizabeth Murphy, PhD, FAHAPeipei Ping, PhD, FAHACoralie Poizat, PhDSumanth Prabhu, MD, FAHAWilliam Pu, MDGangjian Qin, MDMilica Radisic, PhDHoward Rockman, MDAnthony Rosenzweig, MD, FAHASakthivel Sadayappan, PhD, FAHAJunichi Sadoshima, MD, PhD, FAHA Farah Sheikh, PhD, FAHAMark A. Sussman, PhD, FAHAJil C. Tardiff, MD, PhD, FAHA Rong Tian, MD, PhDJennifer Van Eyk, PhD, FAHATom M. Vondriska, PhD, FAHAXuejun Wang, MD, PhDXander Wehrens, MD, PhD, FAHARobert Weiss, MDSean M. Wu, MD, PhDKatherine E. Yutzey, PhD, FAHAJianyi Zhang, MD, PhD, FAHA

SAVE THE DATE!©2016, American Heart Association 6/16DS11041


July 10–13 | Hilton Portland & Executive Tower | Portland, OR


DS-11041 BCVS16 SYNY Ad.indd 2 6/15/16 11:11 AM


Activity Hotel Location, Level/Floor

Sunday, July 17

ACRE Meeting Ellis Room (Level 2)

Monday, July 18

Exhibits Atrium (Level 2)

General Sessions Regency Ballroom (Level 1)

Poster Session Atrium (Level 2)

Refreshment Breaks Atrium (Level 2)

Registration Regency Ballroom Foyer (Level 1)

Speaker Resource Room Regency Ballroom Foyer (Level 1)

Tuesday, July 19

Continental Breakfast Atrium (Level 2)

Early Career Workshop/Lunch Phoenix Ballroom (Level 2)







Wednesday, July 20


Early Career Workshop/Lunch Phoenix Ballroom (Level 2)







Council Dinner Regency Ballroom (Level 1)

Thursday, July 21



Refreshment Break Atrium (Level 2)



Room Locator


Program Description

The 12th annual BCVS 2016 Scientific Sessions: Pathways to Cardiovascular Therapeutics has become the premier conference for molecular cardiovascular biology and disease. Sponsored by the American Heart Association Basic Cardiovascular Sciences Council, the conference attracts leading researchers in fields such as microRNAs, cardiac gene and cell therapy, cardiac development and most recently tissue engineering and iPS cells.

The planned agenda includes 15 fast-paced sessions during 3½ days, set in a forum that promotes the relaxed exchange and discussion of cutting edge research in molecular and translational cardiovascular biology and disease. The program includes a diversity of speakers representing the best cardiovascular scientists from around the world.

The organizers continue to embrace the early career cardiovascular scientist with plans to include oral abstract presentations from up-and-coming investigators throughout the program, with one session dedicated for the Young Investigator Award presentations/competition. In addition to stimulating talks, posters from submitted abstracts will be presented in three sessions. The program will once again offer two lunch workshops targeting early career development, with one workshop focusing on different transitioning career paths for trainees and a speed networking event.

Conference Registration

Registration will be in the Regency Ballroom Foyer, and will be open during the following hours:

Monday, July 18 ...............10:00 am–6:00 pm

Tuesday, July 19 ...............7:00 am–6:00 pm

Wednesday, July 20 .........7:00 am–6:00 pm

Thursday, July 21 .............7:00 am–NOON

Exhibits

Beginning Monday, at Noon, visit our Exhibitors, located in the Atrium on Level 2. This year we welcome:

• ACRE-APS

• AJP-Heart and Circulatory Physiology

• Cell Biologics Inc.

• Ideal Protien

• IonOptix

• OmegaBrite

• VisualSonics

Use the participation card on the back of the Exhibitor Guide for a chance to win a premium professional membership for one year, or complimentary registration to BCVS 2017! Just visit participating exhibitors and ask them to stamp your Guide. Once completed, stop by the AHA Membership Booth and turn in your ticket to be entered for a chance to win! Winners will be notified after the meeting. Good luck!

You can also renew your AHA membership and bring your non-member colleagues to learn the latest information about the benefits of membership. The AHA membership booth will be located in the Regency Ballroom Prefunction area on Level 1.

Learning ObjectivesAt the conclusion of the conference, participants will be able to:

• Evaluate the most recent evidence supporting the use of cardioprotective strategies in the setting of acute myocardial infarction.

• Discuss advances in understanding the underlying mechanisms of cardiomyopathies and the development of new therapeutic approaches.

• Assess new models for the use of cardiac progenitor cells in repairing damaged cardiac tissue.

• Examine progress in the development of novel treatment strategies for heart failure.

• Identify new targets for drug discovery and opportunities to participate in the translational research required to identify new interventions and bring them into clinical trials.

General InformationG

EN

ER

AL IN

FOR

MA

TIO

N


Joint Accreditation Statements

The American Heart Association is accredited by the American Nurses Credentialing Center (ANCC), the Accreditation Council for Pharmacy Education (ACPE), and the Accreditation Council for Continuing Medical Education (ACCME), to provide continuing education for the healthcare team.

AMA Credit Designation Statement – Physicians

The American Heart Association designates this live activity for a maximum of 26.50 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

AAPA Credit Acceptance Statement – Physician Assistants

AAPA accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by ACCME or a recognized state medical society. Physician assistants may receive a maximum of 26.50 hours of Category 1 credit for completing this program.

AANP Credit Acceptance Statement – Nurse Practitioners

American Academy of Nurse Practitioners (AANP) accepts AMA PRA Category 1 CreditTM from organizations accredited by the ACCME.

**AMA Credit must be claimed within 6 months of attendance. Credit will no longer be available to claim after January 21, 2017.

Disclosure Policy

All persons who develop and/or control educational content in CME/CE activities provided by the American Heart Association will disclose to the audience all financial relationships with any commercial supporters of this activity as well as with other commercial interests whose lines of business are related to the CME/CE-certified content of this activity. In addition, presenters will disclose unlabeled/unapproved uses of drugs or devices discussed in their presentations. Such disclosures will be made in writing in course presentation materials.

Web Reources

HealthJobsPlus for Professionals The American Heart Association, in partnership with Lippincott Williams & Wilkins (a Wolters Kluwer business), is proud to offer HealthJobsPlus.com. HealthJobsPlus.com provides a first-rate source for those seeking and posting jobs by connecting qualified healthcare professionals with top-notch employers.

Professional.heart.org Professional Heart Daily is the American Heart Association/American Stroke Association’s powerful Internet resource for healthcare professionals devoted to the fight against cardiovascular disease and stroke. Depending on the level of membership selected, AHA/ASA Professional Members may have free access to all 11 AHA scientific journals, biweekly clinical updates, core clinical textbooks, a continually updated drug database, and much more. Also available from this site are links to the BCVS 2016 Scientific Sessions website, Science News and the AHA’s Professional Online Network.

learn.heart.org This website is where healthcare professionals can complete the conference evaluation and claim CME/CE credits after the meeting. Also available on learn.heart.org are podcasts, online courses, satellite broadcasts and webcasts.

Twitter Use Twitter to tweet your questions/comments during the meeting or to talk about what’s happening at BCVS 2016. Use hashtag: #BCVS16.

General Information (continued)

GE

NE

RA

L IN

FOR

MA

TIO

N


PR

ES

EN

TE

R IN

FOR

MA

TIO

N

Speaker Resource Room

The Speaker Resource Room is located in the Regency Ballroom Foyer on Level 1 of the hotel. Speakers are asked to deliver their presentations on CD-ROM, DVD-ROM or a USB storage device to the Speaker Resource Room at least three hours before the beginning of the session in which they will speak. It is imperative that you review your presentation in the Speaker Resource Room if it contains video files or was created on a Mac. Speakers will be directed to a preloading station where a technician will be on hand to load the presentations. Speakers may also use this room to review and practice their presentations on both PC and Mac computers.

The Speaker Resource Room will be open during these hours:

Monday, July 18 10:00 am–6:00 pm Wednesday, July 20 7:00 am–6:00 pm

Tuesday, July 19 7:00 am–6:00 pm Thursday, July 21 7:00 am–Noon

Abstract Presentations

Abstract presentations for the Basic Cardiovascular Sciences 2016 Scientific Sessions are embargoed for release at the time of presentation or time of AHA news event. Information may not be released before the scheduled presentation time

Abstracts will be published in the October online edition of the AHA journal Circulation Research.

Abstracts will be presented as follows:

Poster Session 1 Monday, July 18 6:00-7:30 pm Presentations 20-140Poster Session 2 Tuesday, July 19 5:20-6:50 pm Presentations 200-321Poster Session 3 Wednesday, July 20 6:00-7:30 pm Presentations 350- 471

Poster Presenters, please note the schedule below:

Poster Session 1 Set-up time: Monday, July 18 NOON–5:00 pm Attended time: Monday, July 18 6:00-7:30 pm Tear-down time: Tuesday, July 19 before 9:00 am

Poster Session 2 Set-up time: Tuesday, July 19 NOON–5:00 pm Attended time: Tuesday, July 19 5:20–6:50 pm Tear-down time: Wednesday, July 20 before 9:00 am

Poster Session 3 Set-up time: Wednesday, July 20 NOON–5:00 pm Attended time: Wednesday, July 20 6:00–7:30 pm Tear-down time: Thursday, July 21 before 9:00 am

New for 2016! ePosters

In addition to the traditional poster format, abstract presenters were invited to upload their posters electronically. During the meeting, each abstract will have a QR code displayed on their poster board that will enable attendees with smartphones to view the ePosters and, if applicable, the author’s narration of the poster. ePosters are available only to attendees and may be viewed from the Communication Center in the registration area. Posters will be accessible to the general public after the meeting.

Information for Presenters


CO

NFE

RE

NC

E H

IGH

LIG

HT

S

Keynote Lecture

Brian K. Kobilka, MD, will present Structural Insights into GPCR Signaling: Implications for Drug Discovery at 3:20 pm Monday, July 18.

Dr. Kobilka is professor of molecular and cellular Physiology, and Hélène Irwin Fagan Chair in Cardiology at Stanford University School of Medicine. He received a BS in biology and chemistry from the University of Minnesota, Duluth in 1977. He graduated from Yale University School of Medicine in 1981, and completed residency training in internal medicine at the Barnes Hospital, Washington University School of Medicine, in St. Louis, Missouri in 1984. From 1984-89, he was a postdoctoral fellow in the laboratory of Robert Lefkowitz at Duke University. In 1990 he joined the faculty of Medicine and Molecular and Cellular Physiology at Stanford University.

Research in the Kobilka lab focuses on the structure and mechanism of action of G protein coupled receptors (GPCRs), which constitute the largest family of receptors for hormones and neurotransmitters in the human genome. GPCRs are the largest group of targets for new therapeutics for a very broad spectrum of diseases.

In 2012, Kobilka was awarded the Nobel Prize in Chemistry for his work on GPCRs. He is a member of the National Academy of Sciences, the National Academy of Medicine and the American Academy of Arts and Sciences.

Conference Highlights

The most revolutionary research in areas such as cellular therapy/stem cells, microRNA biology, diabetes, oxidative stress, translational studies, clinical research, and more.

EDITOR-IN-CHIEFRoberto Bolli, MD

A subscription to Circulation Research includes access online and on your iPad®.

5-Q074

Circulation ResearchAn American Heart Association Journal

circres.ahajournals.org

Apple and iPad are trademarks of Apple Inc., registered in the U.S. and other countries. App Store is a service mark of Apple Inc.

Submit Your Manuscript

Free, Expert-Selected Articles

Read, download and share expert-selected articles available online for free with each issue.

http://circres-submit.aha-journals.org

AVERAGE TIME TO FIRST DECISION IS LESS THAN 14 DAYS


CO

NFE

RE

NC

E H

IGH

LIGH

TS

Outstanding Early Career Investigator Award Finalists’ Presentations

The three finalists will present their abstracts at 1:15 pm Wednesday, July 20. The winner will be announced Wednesday evening during the Basic Cardiovascular Sciences Council Dinner. Refer to page 14 for more information on award finalists.

Early Career Development Workshops

Join us on Tuesday and Wednesday for these sessions targeted for Early Career attendees. These workshops are open to all attendees. However, a ticket is required to attend. Check with the Registration Desk for availability.

Tuesday, July 19, NOON–1:30 pm

Planning Ahead: Choosing the Right Career PathNichole H. Purcell, PhD, University of California-San Diego, La Jolla, California

Beyond the Bench: Marketing Yourself for Non-academic PositionsTimothy McKinsey, PhD, University of Colorado, Aurora, Colorado

Submitting and Reviewing for AHA JournalsJonathan Schultz, Circulation Research Journal, Baltimore, Maryland

Wednesday, July 20, NOON–1:15 pm

The Importance of Good Mentorship and NetworkingBurns C. Blaxall, PhD, FAHA, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio

Speed Networking – Faculty ParticipantsPilar Alcaide, PhD Walter J. Koch, PhD, FAHABurns C. Blaxall, PhD, FAHA Ronglih Liao, PhD, FAHASaumya Das, MD, PhD Joy Lincoln, PhDJohn Elrod, PhD Jeffrey D. Molkentin, PhDÅsa Gustafsson, PhD, FAHA Nichole H. Purcell, PhDJoshua Hare, MD, FAHA Gangjian Qin, MDJoseph A. Hill, MD, PhD, FAHA Sakthivel Sadayappan, PhD, FAHASteven R. Houser, PhD, FAHA Susan F. Steinberg, MD, FAHAMichael Kapiloff, MD, PhD, FAHA Mark A. Sussman, PhD, FAHALorrie A. Kirshenbaum, PhD, FAHA

Council on Basic Cardiovascular Sciences Dinner

On Wednesday, July 20, please plan to join us for food, drinks and entertainment at the BCVS Council Dinner in the Regency Ballroom. Tickets, if available, may be purchased at the AHA Registration Desk ($60 per person for conference registrants and their guests).

Conference Highlights – Early Career and Ticketed Events


CO

NFE

RE

NC

E H

IGH

LIG

HT

S

Conference Highlights – Awards The American Heart Association Council on Basic Cardiovascular Sciences provides educational programs, awards/scholarships, travel grants and mentoring opportunities that support the ongoing training and development of individuals in the early stages of their careers.

The council is pleased to announce the finalists and winners of the following awards:

Outstanding Early Career Investigator Award Finalists

The Outstanding Early Career Investigator Award finalists will present their abstracts during a special oral session scheduled at 1:15-2:00 pm Wednesday, July 20. The winner will be announced at the Council Dinner that evening.

Name/Institution Abstract Number

Fabrice Jaffre, Beth Israel Deaconess Medical Center 1 Sadia Moshin, Temple University 2 Junko S. Warren, University of Utah 3

Cardiovascular Outreach Award Recipients

Name Abstract/Poster Number

Martha Iveth Garcia 388 Shavonn Harper 116 Tanoya Harris 456 Rafael Jaimes 465 Leonardo Leon 103 Tania Nevers 424 Trevi Ramirez 425 Navya Reddy 232 Priscila Sato 449 Shaunrick Stoll 469 Aline Yonezawa 219

New Investigator Travel Award Recipients

Name Abstract/Poster Number

David Barefield 391 Ahmed Bayoumi 112 Zuzana Broskova 293 Danielle Bruns 249 Sherin Hashem 224 Carolin Lerchenmueller 422 Daniela Liccardo 67 Zhiqiang Lin 246 Timothy Luongo 435 Elena Matsa 289 Qinghang Meng 95 Vaibhav Patel 80 Iñigo Valiente-Alandi 264 Yujia Yue 40 Yi Zhang 87


PO

LICY

INFO

RM

AT

ION

DisclaimerThe Basic Cardiovascular Sciences Scientific Sessions is a scientific and educational conference for exchanging and discussing research results and scientific developments in the field of cardiovascular disease. Accordingly, the American Heart Association cannot and does not offer any assurance or warranty of the accuracy, truthfulness or originality of the information presented at the conference.

Embargo GuidelinesAbstracts, lectures and presentations in BCVS 2016 are embargoed for release at the time of presentation. Information may not be released before the scheduled presentation time.

Photography/Recording PolicyNo person may record any portion of the AHA Scientific Sessions, scientific conferences and the AHA/ASA International Stroke Conference, whether by video, still or digital photography; audio; or any other recording or reproduction mechanism. This includes recording of presentations and supporting A/V materials and of poster presentations and supporting poster materials.

Additionally, science information shared by investigators during a meeting is confidential and often unpublished data. Taking photos of or recording the content of meeting room slides is also prohibited, and is considered intellectual piracy and unethical. Attendees who ignore this policy will be asked to leave the educational session and are at risk of losing their badge credentials.

The American Heart Association will take photographs and video during its conferences and may display, reproduce and/or distribute them in AHA educational, news or promotional material, whether in print, electronic or other media, including the AHA website. Your registration for an AHA conference is your grant to AHA the right to use your name, image and biography for such purposes as well as any other purpose. All photographs and/or videos become the property of AHA.

No Smoking PolicyAHA policy prohibits smoking in conference meeting rooms and exhibits/registration areas. Thank you for your cooperation.

Seating/Badge RequirementSeating is on a first-come, first-served basis. According to fire code, a session must be closed if the room fills to capacity. You must wear your name badge at all times during the symposium. Nonregistered guests may not be permitted into the sessions or food and beverage events. Be sure to remove your badge when you leave the conference or your hotel room.

The American Heart Association reserves the right to revoke or deny attendance to any registered participant, speaker, exhibitor, news media reporter or photographer of presentations or activities at AHA/ASA scientific conferences and meetings.

Americans with Disabilities Act (ADA)We encourage participation by all individuals. If you have a disability, advance notification of any special needs will help us to serve you better. Please indicate what your needs are at the time of registration. We cannot ensure the availability of appropriate accommodations without prior notification.

Please note: The American Heart Association shall not be liable for cancellation of the Basic Cardiovascular Sciences 2016 Scientific Sessions caused by labor strikes, civil disorders, fires, weather conditions, or other acts of God for any damages or losses resulting from such cancellations.

Policy Information


Program AgendaMONDAY, JULY 18

10:00 am

RegistrationRegency Ballroom Foyer (Level 1)

12:00 pm

Exhibits OpenAtrium (Level 2)

1:00–1:20 pm Conference Opening Welcome Regency Ballroom (Level 1)

1:00 Ronglih Liao, PhD, FAHA, BCVS Council Leadership Chair, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts Joseph C. Wu, MD, PhD, FAHA, BCVS Council Leadership Vice Chair, Stanford University School of Medicine, Stanford, California

1:10 Welcome Address Steven R. Houser, PhD, FAHA, Temple University School of Medicine, Philadelphia, Pennsylvania, and AHA President

1:20-3:10 pm Regency Ballroom (Level 1) Session 1 Mechanisms of Cardiac Energy Production and Stimulation

Moderators: Robert G. Weiss, MD, Johns Hopkins Hospital and University School of Medicine, Baltimore, Maryland David J. Lefer, PhD, FAHA, Louisiana State University Health Sciences Center, New Orleans, Louisiana

1:20 Mitochondrial Reticulum for Cellular Energy Distribution in Muscle Robert S. Balaban, PhD, National Institutes of Health/National Heart, Lung, and Blood Institute, Bethesda, Maryland

1:40 Resilient Heart: Mitochondria OXPHOS and Carbon Substrates Jianyi Zhang, MD, PhD, FAHA, The University of Alabama at Birmingham, Birmingham, Alabama

2:00 Mechanisms of Energy Substrate Metabolism and Cardiac Function E. Douglas Lewandowski, PhD, FAHA, Stanford Burnham Prebys Medical Discovery Institute, Orlando, Florida

2:20 Myocardial Metabolism and Acetylation in Heart Failure Rong Tian, MD, PhD, University of Washington, Seattle, Washington

2:40 Feeding the Starving Heart: Target Discovery Approaches Daniel P. Kelly, MD, FAHA, Stanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, Florida

Oral Abstract Presentation

3:00 Mitochondrial Fission in the Heart is an 431 Adaptation to Increased Energetic Demands: The Role of Physiologic Fragmentation Michael Coronado, Giovanni Fajardo, Kim Nguyen, Mingming Zhao, Kristina Bezold Kooiker, Gwanghyun Jung, Dong-Qing Hu, Sushma Reddy, Erik Sandoval, Stanford Univ, Stanford, CA; Aleksandr Stotland, Roberta Gottlieb, Cedars-Sinai Medical Ctr, Los Angeles, CA; Daniel Bernstein, Stanford Univ, Stanford, CA

3:10–3:55 pm Regency Ballroom (Level 1) Session 2 Keynote Lecture

Moderator: Ronglih Liao, PhD, FAHA, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts Joseph C. Wu, MD, PhD, FAHA, Stanford University School of Medicine, Stanford, California

3:10 Structural Insights into GPCR Signaling: Implications for Drug Discovery Brian K. Kobilka, MD, Stanford University School of Medicine, Stanford, California

3:55–4:10 pm

Refreshment Break/ExhibitsAtrium (Level 2)

4:10–6:00 pm Regency Ballroom (Level 1) Session 3 Exosomes, Extracellular Vesicles and Cardiovascular Function

Moderators: Michael E. Davis, PhD, FAHA, Emory University School of Medicine, Atlanta, Georgia Susmita Sahoo, PhD, Mount Sinai Icahn School of Medicine, New York, New York

4:10 Exosomes and Pressure Overload Howard Rockman, MD, FAHA, Duke University, Durham, North Carolina

4:30 Cellular and Extracellular Non-coding RNA and Vascular Function Andrew H. Baker, MD, PhD, FAHA, University of Glasgow Institute of Cardiovascular and Medical Sciences, Glasgow, United Kingdom

MO

ND

AY


Program Agenda (continued)

MO

ND

AY

/TU

ES

DA

Y

4:50 Plasma Exosomes and Myocardial Protection from Ischemia-reperfusion Sean M. Davidson, PhD, The Hatter Cardiovascular Institute, London, United Kingdom

5:10 Exosomes as Therapeutic Agents for Heart Disease Eduardo Marban, MD, PhD, FAHA, Cedars-Sinai Heart Institute, Los Angeles, California

5:30 Embryonic Stem Cell Exosomes and Augmentation of Endogenous Myocardial Repair Mohsin Khan, PhD, Temple University, Philadelphia, Pennsylvania


5:50 Stem Cell-derived Exosomes Induce 206 Cardiac Repair via mRNA Modification Prabhu Mathiyalagan, Yaxuan Liang, Adriano S. Martins, Douglas W Losordo, Roger J. Hajjar, Susmita Sahoo, Icahn Sch of Med at Mount Sinai, New York, NY

6:00– 7:30 pm Atrium (Level 2) Poster Session 1

TUESDAY, JULY 19

7:00 am


7:00–8:00 am

Continental Breakfast/ExhibitsAtrium (Level 2)

8:00–9:50 am Regency Ballroom (Level 1) Session 4 Mitochondrial Dynamics and Quality Control

Moderators: Zoltan P. Arany, MD, PhD, University of

Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania Åsa Gustafsson, PhD, FAHA, University of California-San Diego, La Jolla, California

8:00 Parkin-Mediated Mitophagy and Mitochondrial Reprogramming Gerald W. Dorn, MD, FACC, FAHA, Washington University, St. Louis, Missouri

8:20 Role of Alternative Autophagy in Mitochondrial Quality Control Junichi Sadoshima, MD, PhD, FAHA, Rutgers New Jersey Medical School, Newark, New Jersey

8:40 Therapeutic Potential of Mitochondrial Dynamics and Mitophagy Julio C.V. Ferriera, PhD, University of Sao Paolo, Sao Paolo, Brazil

9:00 Mitochondrial DNA Damage and Repair in Heart Failure David J. Lefer, PhD, FAHA, LSU Health Sciences Center, New Orleans, Louisiana

9:20 Mitochondrial Quality Control in Diabetic Heart Qianrong Liang, MD, PhD, New York Institute of Technology, Old Westbury, New York


9:40 NF-kB Mediated Modulation of 271 mir-23b/-130a-axis is Critical for Cardiac Remodeling Sudhiranjan Gupta, Li Li, Cardiovascular Res Inst, Temple, TX

9:50–10:05 am


10:05–11:55 am Regency Ballroom (Level 1) Session 5 Novel Mediators of Cardiac Cell Death and Aging

Moderators: Rick N. Kitsis, MD, FAHA, Albert Einstein College of Medicine, Bronx, New York Yibin Wang, PhD, FAHA, David Geffen School

of Medicine at UCLA, Los Angeles, California

10:05 Autophagy and Adaptation to Cardiac Aging Åsa Gustafson, PhD, FAHA, University of California San Diego, La Jolla, California

10:25 Regulation of Necrotic Cardiac Cell Death Lorrie A. Kirshenbaum, PhD, FAHA, St. Boniface Hospital Research Center, Winnipeg, Manitoba, Canada

10:45 Regulators of Cardiorenal Fibrosis and Dysfunction in Aging John C. Burnett, Jr., MD, FAHA, Mayo Clinic, Rochester, Minnesota

11:05 Arrestin-like Proteins, Fructose and the Metabolic Syndrome Richard Lee, MD, FAHA, Brigham and Women’s Hospital, Boston, Massachusetts

11:25 Acute Catecholamine Exposure Causes ReversibleMyocyte Injury and Myocyte Necrosis without Cardiac RegenerationSteven R. Houser, PhD, FAHA, Temple University School of Medicine, Philadelphia, Pennsylvania




11:45 IL10-inhibits Fibroblast Progenitor 99 Cell-mediated Cardiac Fibrosis in Pressure-overloaded Myocardium Suresh K. Verma, Venkata N Garikipati, Ctr for Transnational Med, Temple Univ, Philadelphia, PA; Prasanna Krishnamurthy, Houston Methodist Res Inst, Houston, TX; Cindy Benedict, Emily Nickoloff, Raj Kishore, Ctr for Transnational Med, Temple Univ, Philadelphia, PA

NOON–1:30 pm Phoenix Ballroom (Level 2) Early Career Development Workshop Luncheon 1 (Ticket required to attend)

Moderators: Saumya Das, MD, PhD, Harvard Medical

School, Beth Israel Deaconess Medical Center, Boston,Massachusetts Sarah Franklin, PhD, University of Utah,

Salt Lake City, Utah

12:00 Planning Ahead: Choosing the Right Career Path Nichole H. Purcell, PhD, University of California San Diego, La Jolla, California

12:30 Beyond the Bench: Marketing Yourself for Non-academic Positions Timothy McKinsey, PhD, University of Colorado, Aurora, Colorado

1:00 Submitting and Reviewing for AHA Journals Jonathan Schultz, Circulation Research Journal, Baltimore, Maryland

1:30–3:20 pm Regency Ballroom (Level 1) Session 6 Non-coding and Extracellular RNAs as Modulators of Cardiovascular Disease

Moderators: Gangjian Qin, MD, Northwestern University,

Feinberg Cardiovascular Research Institute, Chicago, Illinois Guianluigi Condorelli, MD, PhD, Humanitas

Research Hospital, Rozzano (Milan), Italy

1:30 Therapeutic Potential of Non-coding RNAs in Cardiac Hypertrophy and Fibrosis Rusty L. Montgomery, PhD, miRagen Therapeutics, Boulder, Colorado

1:50 Regulation of Systemic Energy Metabolism by Long Non-coding RNAs Haiming Cao, PhD, National Institutes of Health/National Heart, Lung, and Blood Institute, Bethesda, Maryland

2:10 The COP9 Signalosome: A Posttranscriptional Cop in the Heart Xuejun Wang, MD, PhD, FAHA, University of South Dakota, Vermillion, South Dakota

2:30 �β-Arrestin-Mediated β-Adrenergic Receptor Signaling and MicroRNA Biogenesis in Heart Failure Il-man Kim, PhD, Augusta University, Augusta, Georgia

2:50 Extracellular RNAs and Cardiovascular Disease Anthony Rosenzweig, MD, FAHA, Massachusetts General Hospital, Boston, Massachusetts


3:10 MicroRNA-125b-5p Protect the Mouse 293 Heart from Ischemic Injury by Repressing Pro-apoptotic Bak1 and Klf13 in Cardiomyocytes Zuzana Broskova, Kyoung-mi Park, Yongchao Wang, Il-man Kim, Augusta Univ, Augusta, GA

3:20–3:30 pm


3:30–5:20 pm Regency Ballroom (Level 1) Session 7 Signaling Mechanisms of Heart Function and Failure: Novel Insights

Moderator: Michael Kapiloff, MD, PhD, FAHA, University of Miami, Miami, Florida Susan F. Steinberg, MD, FAHA, Columbia

University Medical Center, New York, New York

3:30 Induction of Cell Types in Direct Cardiac Reprogramming Hisayuki Hashimoto, MD, PhD, UT Southwestern Medical Center, Dallas, Texas

3:50 Novel Roles for GRKs in Cardiac Signaling and Disease Walter J. Koch, PhD, FAHA, Temple University School of Medicine, Philadelphia, Pennsylvania

4:10 Tension Sensing Model Predicts Cardiac Hypertrophic Growth Jeffery D. Molkentin, PhD, Children’s Hospital Medical Center, Cincinnati, Ohio

4:30 Prevention of PKG1α Oxidation Augments Cardioprotection in the Stressed Heart David A. Kass, MD, FAHA, Johns Hopkins University, Baltimore, Maryland

4:50 Regulation of Inflammation and Fibrosis through Cardiomyocyte Cam Kinase II Joan Heller Brown, PhD, FAHA, University of California-San Diego, La Jolla, California

TU

ES

DA

Y




5:10 Role of GRKs in Aldosterone Mediated Cardiac DysfunctionAlessandro Cannavo, Temple Univ, Philadelphia, PA

5:20–6:50 pm Atrium (Level 2) Poster Session 2

WEDNESDAY, JULY 20

7:00 am


7:00–8:00 am

Continental Breakfast/ExhibitsAtrium (Level 2)

8:00–9:30 am Regency Ballroom (Level 1) Session 8 Organ on a Chip: iPS Cells in Disease Modeling of Cardiovascular System

Moderators: Milica Radisic, PhD, University of Toronto, Toronto, Ontario, Canada Young-sup Yoon, MD, PhD, FAHA, Emory

University, Atlanta, Georgia

8:00 iPSC Technology for Recreating Heart Disease in a Dish Joseph C. Wu, MD, PhD, FAHA, Stanford University School of Medicine, Stanford, California

8:20 AngioChip Technology for Vascularization and Organ-on-chip Engineering Milica Radisic, PhD, University of Toronto, Toronto, Ontario, Canada

8:40 Microphysiological Organ Systems for Cardiac Drug Testing Kevin E. Healy, PhD, University of California Berkeley, Berkeley, California

9:00 Hypoxia Preconditioning in Cardiac Cell Therapy Jian-an Wang, MD, PhD, No. 2 Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China


9:20 The Estrogen-Related Receptor Gamma 110 Promotes Maturation of iPSC-derived Cardiac Myocytes Tomoya Sakamoto, Teresa C. Leone, Sanford Burnham Prebys Medical Discovery Inst, Orlando, FL; Huei-Sheng Vincent Chen, Sanford Burnham Prebys Medical Discovery Inst, San Diego, CA; Rick B. Vega, Daniel P. Kelly, Sanford Burnham Prebys Medical Discovery Inst, Orlando, FL

9:30–9:45 am Refreshment Break/Exhibits Atrium (Level 2)

9:45–11:55 am Regency Ballroom (Level 1) Session 9 Cardiac Development and Congenital Disease

Moderators: Da-Zhi Wang, PhD, FAHA, Boston Children’s Hospital, Boston, Massachusetts Sean M. Wu, MD, PhD, Stanford University

School of Medicine, Stanford, California

9:45 Characterization of a Hand 1 Left Ventricular Enhancer and Development of a Left Ventricular Specific Cre Driver Anthony B. Firulli, PhD, Indiana University, Indianapolis, Indiana

10:05 An IGF1R-dependent Pathway Drives Adipogenic Differentiation of Epicardial Progenitor Cells Following Myocardial Injury William T. Pu, MD, Harvard Medical School, Boston, Massachusetts

10:25 Molecular Mechanisms and Therapeutic Approaches for Heart Valve Disease Katherine E. Yutzey, PhD, FAHA, Cincinnati Children’s Medical Center, Cincinnati, Ohio

10:45 Heterogeneity of the Heart Valve Interstitial Cell Population Joy Lincoln, PhD, Nationwide Children’s Hospital, Columbus, Ohio

11:05 Notch-Tnf Signaling is Required for Development and Homeostasis of Arterial Valves Bin Zhou, MD, PhD, FAHA, Albert Einstein College of Medicine, Bronx, New York

11:25 Regenerative Potential of Embryo-like Adult Mononuclear Cardiomyocytes Assessed through a Forward Genetic Screen in Mice Henry M. Sucov, PhD, USC Keck School of Medicine, Los Angeles, California

TU

ES

DA

Y/W

ED

NE

SD

AY




11:45 Acetylation of Vgll4 Regulates Hippo-yap 246 Signaling and Postnatal Cardiac Growth Zhiqiang Lin, Boston Children Hosp, Boston, MA; Haidong Guo, Shanghai Univ of Traditional Chinese Med, Shanghai, China; Sylvia Zohrabian, Boston Children Hosp, Boston, MA; Yuan Cao, Inst of Molecular Med, Peking Univ, Beijing, China; William T. Pu, Boston Children Hosp, Boston, MA

11:55 am–12:05 pm Regency Ballroom (Level 1 ) Memorial Tribute in Honor of Arnold M. Katz, MD

Joseph A. Hill, MD, PhD, FAHA, UT Southwestern Medical Center, Dallas, Texas

12:05–1:15 pm Phoenix Ballroom (Level 2) Early Career Development Workshop Luncheon 2 (Ticket required to attend.)

Moderators: Konstantinos Drosatos, MSc, PhD, Temple

University School of Medicine, Philadelphia, Pennsylvania Ivonne H. Schulman, MD, FAHA, University of

Miami School of Medicine, Miami, Florida

12:05 The Importance of Good Mentorship and Networking Burns C. Blaxall, PhD, FAHA, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio

12:35 Speed Networking Event Faculty Participants Pilar Alcaide, PhD Burns C. Blaxall, PhD, FAHA Saumya Das, MD, PhD John Elrod, PhD Åsa Gustafsson, PhD, FAHA Joshua Hare, MD, FAHA Joseph A. Hill, MD, PhD, FAHA Steven R. Houser, PhD, FAHA Michael Kapiloff, MD, PhD, FAHA Lorrie A. Kirshenbaum, PhD, FAHA Walter J. Koch, PhD, FAHA Ronglih Liao, PhD, FAHA Joy Lincoln, PhD Jeffrey D. Molkentin, PhD Nichole H. Purcell, PhD Gangjian Qin, MD Sakthivel Sadayappan, PhD, FAHA Susan F. Steinberg, MD, FAHA Mark A. Sussman, PhD, FAHA

1:15–2:00 pm Regency Ballroom (Level 1) Session 10 Outstanding Early Career Investigator Finalist Competition

Moderators: Burns C. Blaxall, PhD, FAHA, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio Sakthivel Sadayappan, PhD, FAHA, Loyola

University Chicago, Maywood, Illinois

1:15 Abnormal Cardiac Differentiation 1 Underlies Cardiac Hypertrophy in Noonan Syndrome with RAF1 Mutation Fabrice Jaffre, Beth Israel Deaconess Medical Ctr, Boston, MA; Gang Wang, Amy Roberts, William Pu, Boston Children’s Hosp, Boston, MA; Andreas Hahn, Giessen Univ, Giessen, Germany; Maria Kontaridis, Beth Israel Deaconess Medical Ctr, Boston, MA

1:30 Cortical Bone Stem Cells Derived 2 Exosomes as Potent Modulator of Cardiac Immune Response and Repair after Injury Sadia Mohsin, Constantine D. Troupes, Mohsin Khan, Yijun Yang, Jaslyn Johnson, Jennifer L. Petovic, Timothy Starosta, Remus M. Berretta, Hajime Kubo, Steven R Houser, Lewis Katz Sch of Med, Temple Univ, Philadelphia, PA

1:45 The Histone Methyltransferase Smyd1 is 3 a Novel Transcriptional Regulator of Cardiac Fatty Acid Metabolism in Mice Junko S. Warren, Dane W. Barton, Mickey Miller, Li Wang, James Cox, Univ of Utah, Salt Lake City, UT; Tatiana N. Yuzyuk, ARUP Labs, Salt Lake City, UT; Alexey V. Zaitsev, Sarah Franklin, Univ of Utah, Salt Lake City, UT

2:00–3:50 pm Regency Ballroom (Level 1) Session 11 Calcium Regulation in Heart Failure

Moderators: Federica del Monte, MD, PhD, Harvard Medical

School, Beth Israel Deaconess Medical Center, Boston, Massachusetts Mark E. Anderson, MD, PhD, FAHA, Johns

Hopkins University School of Medicine, Baltimore, Maryland

2:00 Regulation of MCU and its Role in Cell Death Elizabeth (Tish) Murphy, PhD, FAHA, NIH/NHLBI, Bethesda, Maryland

2:20 RyR2 Post-translational Regulation in Muscular Dystrophy Xander Wehrens, MD, PhD, FAHA, Baylor College of Medicine, Houston, Texas

WE

DN

ES

DA

Y



2:40 CaMKII Signaling and Mitochondria Mark E. Anderson, MD, PhD, FAHA, Johns Hopkins University School of Medicine, Baltimore, Maryland

3:00 Calmodulinopathy – A New Paradigm for Arrhythmogenesis Bjorn Knollmann, MD, PhD, FAHA, Vanderbilt University, Nashville, Tennessee

3:20 Mitochondrial Calcium Signaling in Heart Failure John Elrod, PhD, Temple University, Philadelphia, Pennsylvania


3:40 Cdk5 Is Associated In Cardiac Calcium 111 Channelopathy Masayuki Yazawa, LouJin Song, Columbia Univ, New York, NY

3:50–4:05 pm


4:05–5:55 pm Regency Ballroom (Level 1) Session 12 Non-conventional Players in Cardiac Healing and Regeneration

Moderators: Prasanna Krishnamurthy, MVSc, PhD, FAHA,

Houston Methodist Research Institute, Houston, Texas Mark A. Sussman, PhD, FAHA, San Diego

State University, Heart Institute and Integrated Regenerative Research Institute, San Diego,

California

4:05 Engineered Heart Tissue for Therapeutic Discovery Thomas Eschenhagen, MD, FAHA, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

4:25 FBX032, a Member of the SCF Complex, is Mutated in Dilated Cardiomyopathy Coralie Poizat, PhD, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

4:45 T-cells and Heart Failure Pilar Alcaide, PhD, Tufts Medical Center, Boston, Massachusetts

5:05 Impact of Splenic Macrophages on the Heart Sumanth Prabhu, MD, FAHA, The University of Alabama at Birmingham, Birmingham, Alabama

5:25 Molecular Mechanism of Hypertrophic Cardiomyopathy in Populations of South Asian Descendants Sakthivel Sadayappan, PhD, FAHA, Loyola University Chicago, Maywood, Illinois


5:45 Chromosome Content of Cardiac 350 Progenitor Cells Influence on Regenerative Potential in the Heart Kathleen Broughton, Tiffany Khieu, Nicky Nguyen, San Diego State Univ, San Diego, CA; Sadia Mohsin, Temple Univ, Philadelphia, PA; Pearl Quijada, Jessica Wang, Megan Monsanto, Natalie Gude, Mark Sussman, San Diego State Univ, San Diego, CA

6:00–7:30 pm Atrium (Level 2) Poster Session 3

7:30–10:30 pm Regency Ballroom (Level 1) BCVS Council Dinner (Ticket required to attend.)

THURSDAY, JULY 21

7:00 am


7:00–8:00 am

Continental BreakfastAtrium (Level 2)

8:00–9:20 am Grand Ballroom A Session 13 Genomic and Epigenomic Medicine: Current Frontiers

Moderators: Thomas M. Vondriska, PhD, FAHA, University of

California Los Angeles, Los Angeles, California

8:00 Genomic and Epigenomic Predictors of Cardiovascular Outcomes in Jackson Heart Study Sharon K. Davis, MEd, MPA, PhD, National Human Genome Research Institute/NIH, Bethesda, Maryland

8:20 Epigenetic Control of Cardiomyocyte Autophagy: Tale of 3 Diseases Joseph A. Hill, MD, PhD, FAHA, UT Southwestern Medical Center, Dallas, Texas

8:40 Cardiomyocytes in the Regulation of Post-Infarction Inflammation Jiang Chang, MD, PhD, Texas A&M Health Sciences Center, Houston, Texas

9:00 A Novel Role for Mechanical Junctions in Sinus Node Function in Mice and Men Farah Sheikh, PhD, FCVS, FAHA, University of California-San Diego, La Jolla, California

WE

DN

ES

DA

Y/T

HU

RS

DA

Y


9:20–9:30 pm

Refreshment Break Atrium (Level 2)

9:30–10:50 am Regency Ballroom (Level 1) Session 14 Systems Biology and Genetic Approaches to Novel Therapeutics

Moderators: Giulio Agnetti, PhD, FAHA, Johns Hopkins University, Baltimore, Maryland Marcello Rota, PhD, FAHA, New York Medical

College, Valhalla, New York

9:30 Maximize S-Nitrosylation Detection: Quantifying Pathological Complexity Jennifer Van Eyk, PhD, FAHA, Cedars Sinai Medical Center, Los Angeles, California

9:50 Genetic Correction Strategies for Myopathies Elizabeth McNally, MD, PhD, University of Chicago, Chicago, Illinois

10:10 Spatial and Temporal Dynamics of the Cardiac Mitochondrial Proteome Peipei Ping, PhD, FAHA, David Geffen School of Medicine at UCLA, Los Angeles, California

10:30 Metabolic Signaling in the Heart Steven P. Jones, PhD, FAHA, FAPS, University of Louisville, Louisville, Kentucky

10:50 am–12:10 pm Regency Ballroom (Level 1) Session 15 Cardiac Regeneration: Bench to Bedside

Moderators: Joshua Hare, MD, FAHA, University of Miami, Miami, Florida Jil C. Tardiff, MD, PhD, FAHA, University of

Arizona, Tucson, Arizona

10:50 Ploidy: For Myocardial Adaptation and Regulation Mark A. Sussman, PhD, FAHA, San Diego State University Heart Institute and Integrated Regenerative Research Institute, San Diego, California

11:10 Bone Marrow Stem Cell Therapy Doris A. Taylor, PhD, FAHA, Texas Heart Institute, Houston, Texas

11:30 Cardiac Cell Therapy: Way Forward Roberto Bolli, MD, FAHA, University of Louisville, Louisville, Kentucky

11:50 c-Kit CPC to Cardiomyocyte: What Three Independent Lineage Tracing Mice Tell Us Joshua Hare, MD, FAHA, University of Miami, Miami, Florida

12:10 pm

Adjourn


TH

UR

SD

AY


AB

ST

RA

CT

S

Outstanding Early Career Investigator Award Finalists Oral Abstracts Presented on Wednesday, July 20, 2016

1 Abnormal Cardiac Differentiation Underlies Cardiac Hypertrophy in Noonan Syndrome with RAF1 Mutation Fabrice Jaffre, Beth Israel Deaconess Medical Ctr, Boston, MA; Gang Wang, Amy Roberts, William Pu, Boston Children’s Hosp, Boston, MA; Andreas Hahn, Giessen Univ, Giessen, Germany; Maria Kontaridis, Beth Israel Deaconess Medical Ctr, Boston, MA F. Jaffre: None. G. Wang: None. A. Roberts: None. W.

Pu: None. A. Hahn: None. M. Kontaridis: None.

2 Cortical Bone Stem Cells Derived Exosomes as Potent Modulator of Cardiac Immune Response and Repair after Injury Sadia Mohsin, Constantine D Troupes, Mohsin Khan, Yijun Yang, Jaslyn Johnson, Jennifer L Petovic, Timothy Starosta, Remus M Berretta, Hajime Kubo, Steven R Houser, Lewis Katz Sch of Med, Temple Univ, Philadelphia, PA

i S. Mohsin: None. C.D. Troupes: None. M. Khan: None. Y. Yang: None. J. Johnson: None. J.L. Petovic: None. T. Starosta: None. R.M. Berretta: None. H. Kubo: None. S.R. Houser: None.

This research has received full or partial funding support from the American Heart Association.

3 The Histone Methyltransferase Smyd1 is a Novel Transcriptional Regulator of Cardiac Fatty Acid Metabolism in Mice Junko S Warren, Dane W Barton, Mickey Miller, Li Wang, James Cox, Univ of Utah, Salt Lake City, UT; Tatiana N Yuzyuk, ARUP Labs, Salt Lake City, UT; Alexey V Zaitsev, Sarah Franklin, Univ of Utah, Salt Lake City, UT J.S. Warren: None. D.W. Barton: None. M. Miller: None. L. Wang: None. J. Cox: None. T.N. Yuzyuk: None. A.V. Zaitsev: None. S. Franklin: None.

Abstracts

20 Novel Transfer of Low Viscosity Cyan Methacrylate on the Surfaces of the Sheep Heart Model and Paint Brush Technique Mark Arokiaraj, Pondicherry Inst of Medical Sciences, Pondicherry, India M. Arokiaraj: None.

21 Effect of Hypoxic Preconditioning on Cortical Bone Stem Cells (CBSCs) Giulia Borghetti, Danielle M Trappanese, Sadia Mohsin, Constantine Troupes, Polina Gross, Steven R Houser, Cardiovascular Res Ctr, Temple Univ, Philadelphia, PA G. Borghetti: None. D.M. Trappanese: None. S. Mohsin:

None. C. Troupes: None. P. Gross: None. S.R. Houser:None.

22 Identification of the Nature of Cardiac Resident c-kit+ Cells Chen-Leng Cai, Nishat Sultana, Lu Zhang, Jianyun Yan, Jiqiu Chen, Weibin Cai, Shegufta Razzaque, Dongtak Jeong, Icahn Sch of Med at Mount Sinai, New York, NY; Wei Sheng, Children’s Hosp of Fudan Univ, Shanghai, China; Lei Bu, New York Univ Sch of Med, New York, NY; Mingjiang Xu, Univ of Miami Miller Sch of Med, Miami, FL; Guo-Ying Huang, Children’s Hosp of Fudan Univ, Shanghai, China; Roger Hajjar, Icahn Sch of Med at Mount Sinai, New York, NY; Bin Zhou, Albert Einstein Coll of Med of Yeshiva Univ, Bronx, NY; Anne Moon, Weis Ctr for Res, Geisinger Clinic, Danville, PA C. Cai: None. N. Sultana: None. L. Zhang: None. J. Yan:

None. J. Chen: None. W. Cai: None. S. Razzaque:None. D. Jeong: None. W. Sheng: None. L. Bu: None. M.Xu: None. G. Huang: None. R. Hajjar: None. B. Zhou:None. A. Moon: None.


23 p53 Mediates de novo Cardiomyocte Differentiation From c-kit Positive Cardiac Progenitor Cells Zhongming Chen, Wuqiang Zhu, Amritha Yellamilli, Ingrid Bender, Jop H van Berlo, Univ of Minnesota, Minneapolis, MN Z. Chen: None. W. Zhu: None. A. Yellamilli: None. I.

Bender: None. J.H. van Berlo: None.

24 Hydrogen Sulfide Potentiates Bone Marrow-derived Angiogenic Progenitor Cell-mediated Ischemic Limb Angiogenesis in Diabetic Animals Zhongjian Cheng, Venkata NS Garikipati, Emily Nickoloff, Chunlin Wang, Temple Univ, Philadelphia,, PA; David Polhemus, Louisiana State Univ Health Sciences Ctr, New Orleans, LA; Jibin Zhou, Cynthia Benedict, Suresh K Verma, Mohsin Khan, Joseph E Rabinowitz, Temple Univ, Philadelphia,, PA; David Lefer, Dept of Pharmacology and Experimental Therapeutics and Cardiovascular Ctr of Excellence, New Orleans, LA; Raj Kishore, Temple Univ, Philadelphia,, PA Z. Cheng: None. V. Garikipati: None. E. Nickoloff:

None. C. Wang: None. D. Polhemus: None. J. Zhou:None. C. Benedict: None. S. Verma: None. M. Khan:None. J. Rabinowitz: None. D. Lefer: None. R. Kishore:None.


25 A Streamlined Technique to Stabilize C-kit Expression in Cardiac Mesenchymal Cells Sujith Dassanayaka, Bethany W. Long, Ayesha Zafir, Shahab Ghafghazi, Gregory N Hunt, Camille T Noble, Angelica M DeMartino, Kenneth R Brittian, Steven P. Jones, Marcin Wysoczynski, Univ of Louisville, Louisville, KY S. Dassanayaka: None. B.W. Long: None. A. Zafir:

None. S. Ghafghazi: None. G.N. Hunt: None. C.T. Noble:None. A.M. DeMartino: None. K.R. Brittian: None. S.P.Jones: None. M. Wysoczynski: None.



AB

ST

RA

CT

S

26 The Mir-106b~25 Cluster as a Regenerative Therapy for Myocardial Injury Ellen Dirkx, Andrea Raso, Hamid el Azzouzi, Serve Olieslagers, Maastricht Univ, Maastricht, Netherlands; Roel de Weger, Univ Medical Ctr Utrecht, Utrecht, Netherlands; Sailay Siddiqi, Radboud Univ Medical Ctr Nijmegen, Maastricht, Netherlands; Paula A da Costa Martins, Maastricht Univ, Maastricht, Netherlands; Serena Zacchigna, Mauro Giacca, Intl Ctr for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy; Leon J De Windt, Maastricht Univ, Maastricht, Netherlands E. Dirkx: None. A. Raso: None. H. el Azzouzi: None. S.

Olieslagers: None. R. de Weger: None. S. Siddiqi: None.P.A. da Costa Martins: 7. Ownership Interest; Modest;author is co-founder of Mirabilis Therapeutics BV, a Dutchbiotech aiming to develop microRNA-based drugs. S.Zacchigna: None. M. Giacca: None. L.J. De Windt: 7.Ownership Interest; Significant; author has a patentapplication on the subject and is co-founder of MirabilisTherapeutics BV, a Dutch biotech aiming to develop newmicroRNA-based drugs.

27 Interplay of Prostaglandin E2 and Major Histocompatibility Comeplex-II Determines Immunoprivilege of Allogeneic Mesenchymal Stem Cells in the Ischemic Heart Niketa Sareen, Glen Lester Sequiera, Ejlal Abu Al-Rub, Meenal Moudgil, Sanjiv Dhingra, Inst of Cardiovascular Sciences, St. Boniface Hosp Res Ctr, Winnipeg, MB, Canada N. Sareen: None. G. Sequiera: None. E. Abu Al-Rub:

None. M. Moudgil: None. S. Dhingra: None.

28 Automated Characterization and Quantification of Cardiomyocyte Proliferation and Apoptosis in Post Myocardial Infarction Tissue Images Polina Gross, Temple Univ, Philadelphia, PA; Nicolas Honnorat, Erdem Varol, Univ of Pennsylvania, Philadelphia, PA; Markus Wallner, Danielle Trappanese, Thomas Sharp, Timothy Starosta, Jason Duran, Sarah Koller, Temple Univ, Philadelphia, PA; Christos Davatzikos, Univ of Pennsylvania, Philadelphia, PA; Steven Houser, Temple Univ, Philadelphia, PA P. Gross: None. N. Honnorat: None. E. Varol: None. M.

Wallner: None. D. Trappanese: None. T. Sharp: None. T.Starosta: None. J. Duran: None. S. Koller: None. C.Davatzikos: None. S. Houser: None.

29 Porcine Decellularized Heart Tissue Enhance the Expression of Contractile Proteins in Human Cardiomyocytes and Differentiated Cardiac Progenitor Cells Anne-Cecile Huby, Farideh Beigi, Qian Xiang, Andrea Gobin, Doris Taylor, Texas Heart Inst, Houston, TX A. Huby: None. F. Beigi: None. Q. Xiang: None. A. Gobin:

None. D. Taylor: None.

30 In vitro Fabrication of Human Cardiac Tissues with Porcine Perfusable Blood Vessels Akitoshi Inui, Dept of Cardiac Surgery, The Univ of Tokyo, Tokyo, Japan; Hidekazu Sekine, Kazunori Sano, Izumi Dobashi, Azumi Yoshida, Katsuhisa Matsuura, Inst of Advanced BioMedical Engineering and Science, Tokyo Women's Medical Univ, Tokyo, Japan; Eiji Kobayashi, Dept of Organ Fabrication, Keio Univ Sch of Med, Tokyo, Japan; Minoru Ono, Dept of Cardiac Surgery, The Univ of Tokyo, Tokyo, Japan; Tatsuya Shimizu, Inst of Advanced BioMedical Engineering and Science, Tokyo Women's Medical Univ, Tokyo, Japan

A. Inui: 2. Research Grant; Significant; "Development ofinnovative manufacturing technology for three-dimensionaltissues and organs based on cell sheet engineering” fromJapan Agency for Medical Research and development,AMED. H. Sekine: 2. Research Grant; Significant;"Development of innovative manufacturing technology forthree-dimensional tissues and organs based on cell sheetengineering” from Japan Agency for Medical Research anddevelopment, AMED. K. Sano: 1. Employment; Significant;TOKAI HIT Co., Ltd. 2. Research Grant; Significant;"Development of innovative manufacturing technology forthree-dimensional tissues and organs based on cell sheetengineering” from Japan Agency for Medical Research anddevelopment, AMED. I. Dobashi: 2. Research Grant;Significant; "Development of innovative manufacturingtechnology for three-dimensional tissues and organs basedon cell sheet engineering” from Japan Agency for MedicalResearch and development, AMED. A. Yoshida: 2.Research Grant; Significant; "Development of innovativemanufacturing technology for three-dimensional tissues andorgans based on cell sheet engineering” from Japan Agencyfor Medical Research and development, AMED. K.Matsuura: 2. Research Grant; Significant; "Development ofinnovative manufacturing technology for three-dimensionaltissues and organs based on cell sheet engineering” fromJapan Agency for Medical Research and development,AMED. E. Kobayashi: 2. Research Grant; Significant;"Development of innovative manufacturing technology forthree-dimensional tissues and organs based on cell sheetengineering” from Japan Agency for Medical Research anddevelopment, AMED.. 8. Consultant/Advisory Board;Modest; a medical adviser for Sysmex and Regience Ltd.,Japan. M. Ono: None. T. Shimizu: 2. Research Grant;Significant; "Development of innovative manufacturingtechnology for three-dimensional tissues and organs basedon cell sheet engineering” from Japan Agency for MedicalResearch and development, AMED. 7. Ownership Interest;Modest; CellSeed Inc.

31 First Trimester Human Umbilical Cord Perivascular Cells (FTM HUCPVCs) Show Superior Angiogenic Potential in Angiogenic Potency Assays When Compared to Term HUCPVCs and Bone Marrow Stromal Cells Farwah Iqbal, Peter Szaraz, Univ of Toronto, Toronto, ON, Canada; Jun Wu, Toronto General Res Inst. Univ Health Network, Toronto, ON, Canada; Andree Gauthier-Fisher, Create Fertility Ctr, Toronto, ON, Canada; Ren-Ke Li, Toronto General Res Inst. Univ Health Network, Toronto, ON, Canada; Clifford Librach, Create Fertility Ctr, Toronto, ON, Canada F. Iqbal: None. P. Szaraz: None. J. Wu: None. A.

Gauthier-Fisher: None. R. Li: None. C. Librach: None.


AB

ST

RA

CT

S

32 Intravenous Mobilized Autologous Peripheral Blood CD34+ Stem Cell Transplantation for Angina Hadyanto Lim, Dept of Pharmacology and Molecular Sciences, Faculty of Med, Methodist Univ of Indonesia, Medan, Indonesia; Lindarto Dharma, Dept of Internal Med, Div of Endocrine/Metabolism, Faculty of Med, North Sumatra Univ, Medan, Indonesia; Zein Umar, Dept of Internal Med, Div of Tropical Med and Hygiene, Faculty of Med, Muhammadiyah North Sumatra Univ, Medan, Indonesia; Hariaji Ilham, Dept of Pharmacology and Therapeutics, Faculty of Med, Muhammadiyah North Sumatra Univ, Medan, Indonesia H. Lim: None. L. Dharma: None. Z. Umar: None. H. Ilham:

None.

33 Unlocking Reprogramming Capability: Silencing Antiplasticity Gene p63 Enhances the Reprogramming of Fibroblasts into Induced Cardiomyocytes Vivekkumar Patel, Baylor Coll of Med, Houston, TX; Austin Cooney, Univ of Texas at Austin, Austin, TX; Elsa Flores, Univ of Texas, Houston, TX; Vivek Singh, Megumi Mathison, Deepthi Sanagasetti, Lisa Mullany, Jianchang Yang, Todd Rosengart, Baylor Coll of Med, Houston, TX

V. Patel: 7. Ownership Interest; Modest; Patent Applicationin Process. A. Cooney: None. E. Flores: None. V. Singh:None. M. Mathison: None. D. Sanagasetti: None. L.Mullany: None. J. Yang: None. T. Rosengart: None.

34 Human Cardiac Mesenchymal Cell Derived Extracellular Vesicles Promote Angiogenesis Through Angiopoietin-TIE2 Signaling Asif Pathan, Talha Farid, Abdur Rahman Khan, Marjan Nasr, Marcin Wysoczynski, Roberto Bolli, Univ of Louisville, Louisville, KY A. Pathan: None. T. Farid: None. A. Khan: None. M. Nasr:

None. M. Wysoczynski: None. R. Bolli: None.


35 Enhanced Reprogramming of Human Fibroblasts into Cardiomyocytes Using Minimal Transcription Factors Yang Zhou, Sahar Alimohamadi, Jiandong Liu, Li Qian, Univ of North Carolina at Chapel Hill, Chapel Hill, NC Y. Zhou: None. S. Alimohamadi: None. J. Liu: None. L.

Qian: None.


36 Application of “Omics” to Assess the Inter Passage Variability in the Immunoprivilege of Mesenchymal Stem Cells Glen Lester Sequiera, Niketa Sareen, Inst of Cardiovascular Sciences, St. Boniface Hosp Res Ctr, Winnipeg, MB, Canada; Vikram Sharma, Plymouth Univ Peninsula Schs of Med and Dentistry, Plymouth, United Kingdom; Rakesh Chaudhary, Ejlal Abu Al-Rub, Meenal Moudgil, Amir Ravandi, Sanjiv Dhingra, Inst of Cardiovascular Sciences, St. Boniface Hosp Res Ctr, Winnipeg, MB, Canada G. Sequiera: None. N. Sareen: None. V. Sharma:

None. R. Chaudhary: None. E. Abu Al-Rub: None. M.Moudgil: None. A. Ravandi: None. S. Dhingra: None.

37 Mir-590 Promotes Transdifferentiation of Porcine and Human Fibroblasts Towards a Cardiomyocyte-like Fate by Directly Repressing Specificity Protein 1 (Sp1)

Vivek P Singh, Megumi Mathison, Vivekkumar Patel, Deepthi Sanagasetti, Lina Yang, Mostafa R Naguib, Sonal Somvanshi, Lisa K Mullany, Brian W Gibson, Jianchang Yang, Todd K Rosengart, Baylor Coll of Med, Houston, TX V.P. Singh: None. M. Mathison: None. V. Patel: None. D.

Sanagasetti: None. L. Yang: None. M.R. Naguib: None. S.Somvanshi: None. L.K. Mullany: None. B.W. Gibson:None. J. Yang: None. T.K. Rosengart: None.

38 Engineered Anisotropic Scaffolds Promote the Function of Cocultured Cardiomyocytes Derived From Human Pluripotent Stem Cells Maureen Wanjare, Joseph Jung-Woong Kim, Ngan Huang, Stanford Cardiovascular Inst, Stanford Univ, Palo Alto, CA M. Wanjare: None. J. Jung-Woong Kim: None. N. Huang:

None.

39 Towards Whole Heart Regeneration: Rebuilding Functional Mouse Heart Using Human Cardiovascular Progenitors Bo Lin, TungYing Lu, Jong Kim, Mara Sullivan, Kimimasa Tobita, Guy Salama, Lei Yang, Univ of Pittsburgh, Pittsburgh, PA B. Lin: None. T. Lu: None. J. Kim: None. M. Sullivan:

None. K. Tobita: None. G. Salama: None. L. Yang: None.

40 Interleukin-10 Deficiency Impairs Reparative Properties of Bone Marrow-derived Endothelial Progenitor Cell Exosomes Function in Ischemic Myocardium Yujia Yue, Venkata N Garikipati, Yan Tang, Zhongjian Chen, Jibin Zhou, Emily Nickoloff, Chunlin Wang, Cindy Benedict, Erhe Gao, Mohsin Khan, Suresh Verma, Raj Kishore, Temple Univ, Philadelphia, PA Y. Yue: None. V.N.S. Garikipati: None. Y. Tang: None. Z.

Chen: None. J. Zhou: None. E. Nickoloff: None. C. Wang:None. C. Benedict: None. E. Gao: None. M. Khan:None. S. Verma: None. R. Kishore: None.

41 Cell Cycle Activation of Cardiomyocytes Derived From Induced Pluripotent Stem Cells for Cardiac Regeneration Wuqiang Zhu, Meng Zhao, Saidulu Mattapally, Ling Gao, Jianyi Zhang, Univ of Alabama at Birmingham, Birmingham, AL W. Zhu: None. M. Zhao: None. S. Mattapally: None. L.

Gao: None. J. Zhang: None.

42 Alternative Autophagy Plays a Role in the Effect of RAS-inhibition on Arterial Senescence and Arteriosclerosis Yoshiyuki Ikeda, Masaaki Iwabayashi, Yuichi Sasaki, Yuichi Akasaki, Koji Higuchi, Masaaki Miyata, Mitsuru Ohishi, Cardiovascular Med and Hypertension, Graduate Sch of Med, Kagoshima Univ, Kagoshima, Japan Y. Ikeda: None. M. Iwabayashi: None. Y. Sasaki: None. Y.

Akasaki: None. K. Higuchi: None. M. Miyata: None. M.Ohishi: None.

43 SIRT1 Enhances Oxidized Low-density Lipoprotein Induced Autophagy in Human Valve Interstitial Cells Huadong Li, Dept of Cardiovascular Surgery, Union Hosp, Tongji Medical Coll, Huazhong Univ of Science and Technology, Wuhan, China; Jiawei Shi, FCVRI, Northwestern Univ, Chicago, IL; Weihua Qiao, Nianguo Dong, Dept of Cardiovascular Surgery, Union Hosp, Tongji Medical Coll, Huazhong Univ of Science and Technology, Wuhan, China; Gangjian Qin, FCVRI, Northwestern Univ, Chicago, IL H. Li: None. J. Shi: None. W. Qiao: None. N. Dong:

None. G. Qin: None.


AB

ST

RA

CT

S

44 TAK1 Regulates Caspase 8 Activation and Necroptotic Signaling via Multiple Cell Death Checkpoints Xaioyun Guo, Haifeng Yin, Yi Chen, Lei Li, Jing Li, Qinghang Liu, Univ of Washington, Seattle, WA X. Guo: None. H. Yin: None. Y. Chen: None. L. Li:

None. J. Li: None. Q. Liu: None.

45 The Dark Side of Parkin: The Toxic Effects of Enhanced Parkin Levels Sarah E Shires, Mark A Lampert, Dieter A Kubli, Eileen R Gonzalez, Nicole H Purcell, Åsa B Gustafsson, UC San Diego, La Jolla, CA S.E. Shires: None. M.A. Lampert: None. D.A. Kubli: None. E.R. Gonzalez: None. N.H. Purcell: None. Å.B. Gustafsson: None.


46 Study of Symptoms Variation in the Morning and Evening in Postural Orthostatic Tachycardia Syndrome (POTS) Muhammad Mubashir Ahsan, Chandralekha Ashangari, Amer Suleman, The Heartbeat Clinic, Dallas, TX M.M. Ahsan: None. C. Ashangari: None. A. Suleman:

None.

47 Treatment with a DNA Vaccine in Experimentally Trypanosoma cruzi-infected Dogs Modulates Cellular Immune Response Minerva Arce-Fonseca, Ana C. Carbajal-Hernández, Mónica Lozano-Camacho, Silvia C. Carrillo-Sánchez, Martha Rios-Castro, Olivia Rodríguez-Morales, Insto Nacional de Cardiologia, Ignacio Chavez, Mexico City, Mexico M. Arce-Fonseca: None. A.C. Carbajal-Hernández:

None. M. Lozano-Camacho: None. S.C. Carrillo-Sánchez:None. M. Rios-Castro: None. O. Rodríguez-Morales:None.

48 Differentiation of Moderate and Severe Ischemic Heart Failure by Invasive and Non-invasive Assessments of Diastolic Function in a Rat Model of Chronic Heart Failure Saffie Mohran, Jordan Lancaster, Pablo Sanchez, Steven Goldman, Elizabeth Juneman, Univ of Arizona, Tucson, AZ S. Mohran: None. J. Lancaster: None. P. Sanchez:

None. S. Goldman: None. E. Juneman: None.

49 A Proposed Role for Transmembrane Activator and Cyclophilin Ligand Interactor (TACI) in Cardiovascular Disease: Adaptive Immunity and Atherosclerosis Omar A. Meelu, Mount Sinai Heart, Mount Sinai Hosp, New York, New York, NY O.A. Meelu: None.

50 DNA Methylation Signatures in Blood Distinguish Patients at Risk of Post-operative Atrial Fibrillation Following Cardiopulmonary Bypass Emma Monte, Matthew A Fischer, Nicholas Wisniewski, Jennifer Scovotti, Kimberly Howard-Quijano, Todd Kimball, Ira Hofer, Yibin Wang, Matteo Pellegrini, Aman Mahajan, Thomas Vondriska, UCLA, Los Angeles, CA E. Monte: None. M.A. Fischer: None. N. Wisniewski:

None. J. Scovotti: None. K. Howard-Quijano: None. T.Kimball: None. I. Hofer: None. Y. Wang: None. M.Pellegrini: None. A. Mahajan: None. T. Vondriska: None.

51 A Unique Combination of SMarTR Bioinformatics and Cardiomyocyte Screening Technology Allows for Development of Novel Cardio-protective Drugs Nirupama Pike, Kevin Kim, Eunhye Park, Chris Armstrong, Stem Cell Theranostics, Redwood City, CA; Lisa Pham, Eithon Cadag, CapellaBio, Palo Alto, CA N. Pike: None. K. Kim: None. E. Park: None. C.

Armstrong: None. L. Pham: None. E. Cadag: None.

52 Isolation, Characterization and Partial Direct Differentiation of Patient Derived Human Primary Cardiac and Placental Fibroblasts from Surgical Discard Tissue into Induced Mesoderm Progenitor Cell Pouya Sadeghi Pour, Costanza Emanueli, Massimo Caputo, Gianni Angelini, Univ of Bristol, Bristol, United Kingdom P. Sadeghi Pour: None. C. Emanueli: None. M. Caputo:

None. G. Angelini: None.

53 Characterization of a Feline HFpEF Model Induced by Slow Progressive Pressure Overload Markus Wallner, Remus M Berretta, Lewis Katz Sch of Med, Temple Univ, Philadelphia, PA; Shu-Yu Sun, Kersten M Small, Jeffrey B Madwed, Merck Res Labs, Kenilworth, NJ; Constantine D Troupes, Thomas E Sharp III, Giulia Borghetti, Lewis Katz Sch of Med, Temple Univ, Philadelphia, PA; Mark A Oyama, Univ of Pennsylvania, Philadelphia, PA; Philip R Fox, Animal Medical Ctr, New York, NY; Steven R Houser, Lewis Katz Sch of Med, Temple Univ, Philadelphia, PA M. Wallner: None. R.M. Berretta: None. S. Sun: 1.

Employment; Significant; Merck & Co. K.M. Small: 1.Employment; Significant; Merck & Co. J.B. Madwed: 1.Employment; Significant; Merck & Co. C.D. Troupes:None. T.E. Sharp: None. G. Borghetti: None. M.A. Oyama:None. P.R. Fox: None. S.R. Houser: 2. Research Grant;Modest; Merck & Co. 8. Consultant/Advisory Board; Modest;Merck & Co.

54 MicroRNA Let-7d-3p in Heart Failure Lee Lee Wong, Eng Leng Saw, Yue Zhou, Peipei Wang, Arthur Mark Richards, Cardiovascular Res Inst, Natl Univ of Singapore, Singapore, Singapore L. Wong: None. E. Saw: None. Y. Zhou: None. P. Wang:

None. A.M. Richards: None.

55 The Natural Course of Myocardial Infarction in Large Animal Models; a Systematic Review and Meta-analysis Peter-Paul Zwetsloot, Lisanne E Kouwenberg, Univ Medical Ctr Utrecht, Utrecht, Netherlands; Emily S Sena, Ctr for Clinical Brain Sciences, Edinburgh, United Kingdom; Joep E Eding, Joost P Sluijter, Gerard Pasterkamp, Pieter A Doevendans, Steven A Chamuleau, Geert PJ van Hout, Sanne J Jansen of Lorkeers, Univ Medical Ctr Utrecht, Utrecht, Netherlands P. Zwetsloot: None. L.E. Kouwenberg: None. E.S. Sena:

None. J.E. Eding: None. J.P.G. Sluijter: None. G.Pasterkamp: None. P.A. Doevendans: None. S.A.J.Chamuleau: None. G.P. van Hout: None. S.J. Jansen ofLorkeers: None.

56 Growth Hormone Releasing Hormone Improves Sarcomere Relaxation and Calcium Decline in Cardiomyocyte from a Mouse Model of Heart Failure with Preserved Ejection Fraction Raul A Dulce, Rosemeire M Kanashiro-Takeuchi, Lauro M Takeuchi, Wayne Balkan, Renzhi Cai, Andrew V Schally, Joshua M Hare, Univ of Miami Miller Sch of Med, Miami, FL


AB

ST

RA

CT

S

R.A. Dulce: None. R.M. Kanashiro-Takeuchi: None. L.M. Takeuchi: None. W. Balkan: None. R. Cai: None. A.V. Schally: None. J.M. Hare: 8. Consultant/Advisory Board; Significant; Vestion.

57 Myofibrils from Pediatric IDC Patients Display Faster Relaxation Kinetics and Reduced Tension Generation Mark Jeong, Kika Sucharov, Brian Stauffer, Amrut Ambardekar, Yin Lin, Jennifer Mahaffey, Univ of Colorado Denver, Aurora, CO; Shelley Miyamoto, Children's Hosp Colorado, Aurora, CO M. Jeong: None. K. Sucharov: None. B. Stauffer:

None. A. Ambardekar: None. Y. Lin: None. J. Mahaffey:None. S. Miyamoto: None.

58 Differential Ventricular Remodeling Induced by Thin Filament Mutational Effects on the Tropomyosin Overlap Structure Mark McConnell, Univ of Arizona, Tucson, AZ; Lauren Tal-Grinspan, Albert Einstein Coll of Med, New York, NY; Melissa Lynn, Univ of Arizona, Tucson, AZ; Benjamin Schwartz, Univ of California Los Angeles, Los Angeles, CA; Ofer Fass, Harvard Univ, Cambridge, MA; Hassan-Galaydh Farah, Andrea Deranek, Jayant James Jayasundar, Jil C Tardiff, Univ of Arizona, Tucson, AZ M. McConnell: None. L. Tal-Grinspan: None. M. Lynn:

None. B. Schwartz: None. O. Fass: None. H. Farah:None. A. Deranek: None. J. Jayasundar: None. J.C.Tardiff: None.

59 Antimir Therapy Ameliorates HIF1-mediated Loss of SERCA2 and Cardiac Contractility Allison L Williams, Chad Walton, Keith MacCannell, Abigail Avelar, Ralph Shohet, John A. Burns Sch of Med, Honolulu, HI A.L. Williams: None. C. Walton: None. K. MacCannell:

None. A. Avelar: None. R. Shohet: None.

60 Double Hit Mutations in Thoracic Aortic Aneurysm Disease That Have Variable Impact on Phenotype Brett D Hambly, Elizabeth Robertson, Stefanie Portelli, Yaxin Lu, Murat Kekic, Richmond Jeremy, Univ Sydney, Sydney, Australia B.D. Hambly: None. E. Robertson: None. S. Portelli:

None. Y. Lu: None. M. Kekic: None. R. Jeremy: None.

61 Ablation of BKCa Channels Results in Cardiac Hypertrophy Harpreet Singh, Kajol Shah, Devsena Ponnalagu, Sanjay Chandrasekhar, Andrew R. Kohut, Drexel Univ Coll of Med, Philadelphia, PA; Andrea L. Meredith, Univ of Maryland Sch of Med, Baltimore, MD; Shubha Gururaja Rao, Drexel Univ Coll of Med, Philadelphia, PA H. Singh: None. K. Shah: None. D. Ponnalagu: None. S.

Chandrasekhar: None. A.R. Kohut: None. A.L. Meredith:None. S. Gururaja Rao: None.


62 Altered Qtc Intervals and Risk of Arrhythmias Arise in Mice Overexpressing Nitric Oxide Synthase Adapter Protein Nos1ap Tatjana Williams, Daniel Oppelt, Univ Hosp of Wuerzburg, Comprehensive Heart Failure Ctr, Wuerzburg, Germany; Paula-Anahi Arias-Loza, Univ Hosp of Wuerzburg, Dept of Internal Med I, Molecular Cardiology, Wuerzburg, Germany; Marco Abesser, Univ of Wuerzburg, Dept of Physiology, Wuerzburg, Germany; Joachim Schmitt, Univ of Wuerzburg,

Cardiovascular Pharmacology, Wuerzburg, Germany; Kai Schuh, Univ of Wuerzburg, Dept of Physiology, Wuerzburg, Germany; Oliver Ritter, Medical Univ Brandenburg/Havel, Dept of Cardiology and Pneumology, Brandenburg/Havel, Germany T. Williams: None. D. Oppelt: None. P. Arias-Loza:

None. M. Abesser: None. J. Schmitt: None. K. Schuh:None. O. Ritter: None.

63 Reduction in Glucocorticoid Receptor Expression Attenuates Pressure Overload-induced Cardiac Hypertrophy and Promotes Heart Failure in Mice Rongxue Wu, Maura Knapp, Mei Zheng, James K Liao, Univ of Chicago, Chicago, IL R. Wu: None. M. Knapp: None. M. Zheng: None. J. Liao:

None.

64 An Integrated Model for Titin Truncation Mutation Interpretation Jun Zou, Diana Tran, Angelo Pelonero, Rahul C Deo, CVRI, UCSF, San Francisco, CA J. Zou: None. D. Tran: None. A. Pelonero: None. R.C.

Deo: None.


65 Latrophilin-2 is a Specific Cell-surface Marker for Cardiac Progenitor Cells and Specifies Cardiac Lineage Commitment and Development Hyun-Jai Cho, Choon-Soo Lee, Jin-Woo Lee, Jung-Kyu Han, Han-Mo Yang, Yoo-Wook Kwon, Hyo-Soo Kim, Seoul Natl Univ Hosp, Innovative Res Inst for Cell Therapy (IRICT), Seoul, Korea, Republic of H. Cho: None. C. Lee: None. J. Lee: None. J. Han:

None. H. Yang: None. Y. Kwon: None. H. Kim: None.

66 Ascorbate Prevents Hypertension, Proteinuria and Concentric Hypertrophy by Balancing the Nitroso-redox System in a Model of Preeclampsia, the S-nitrosoglutathione Reductase (gsnor) Deficient Mice Shathiyah Kulandavelu, Raul A Dulce, Rosemeire Kanashiro Takeuchi, Wayne Balkan, Joshua M Hare, Univ of Miami, Miami, FL S. Kulandavelu: None. R.A. Dulce: None. R.K. Takeuchi:

None. W. Balkan: None. J.M. Hare: 8. Consultant/AdvisoryBoard; Significant; Vestion.

67 Metabolic Programming Regulates Proliferation and Binucleation of Postnatal Cardiomyocytes Daniela Liccardo, Ryan LaCanna, Ying Tian, Temple Univ Sch of Med, Philadelphia, PA D. Liccardo: None. R. LaCanna: None. Y. Tian: None.

68 p38 MAP Kinase Regulates Chamber Specific Postnatal Remodelling of Cardiac Ventricles Tomohiro Yokota, Jin Li, Qing Zhang, Yichen Ding, Kevin Sung, Christoph Rau, Vincent Ren, UCLA, Los Angeles, CA; Susumu Minamisawa, Jikei Univ, Tokyo, Japan; Tzung Hsiai, Rajan Kulkarni, Xinshu Xiao, Yibin Wang, UCLA, Los Angeles, CA T. Yokota: None. J. Li: None. Q. Zhang: None. Y. Ding:

None. K. Sung: None. C. Rau: None. V. Ren: None. S.Minamisawa: None. T. Hsiai: None. R. Kulkarni: None. X.Xiao: None. Y. Wang: None.


AB

ST

RA

CT

S

69 Cardiomyocyte GSK-3α Signaling Exacerbate Pressure Overload-induced Dilated Cardiomyopathy and Heart Failure Firdos Ahmad, Hind Lal, Vipin K Verma, Qinkun Zhang, Vanderbilt Medical Ctr, Nashville, TN; James R Woodgett, Lunenfeld-Tanenbaum Res Inst, Toronto, ON, Canada; Thomas L Force, Vanderbilt Medical Ctr, Nashville, TN F. Ahmad: None. H. Lal: None. V.K. Verma: None. Q.

Zhang: None. J.R. Woodgett: None. T.L. Force: None.

70 Characterization of Advanced Glycation End Products in a Myocardial Infarction Animal Model Bianca Fracasso, Juliana O Rangel, UFRGS- Univ Federal do Rio Grande do Sul, Porto Alegre, Brazil; Virgílio Olsen, Hosp de Clínicas, Porto Alegre, Brazil; Amanda Phaelante, Fernanda Curuja, Amanda Lopes, UFRGS- Univ Federal do Rio Grande do Sul, Porto Alegre, Brazil; Luis E Rohde, Andreia Biolo, Michael Andrades, Hosp de Clínicas, Porto Alegre, Brazil B. Fracasso: None. J.O. Rangel: None. V. Olsen:

None. A. Phaelante: None. F. Curuja: None. A. Lopes:None. L.E.P. Rohde: None. A. Biolo: None. M. Andrades:None.

71 Model of Induced Ventricular Tachycardia and Cardiac Electrophysiological Mapping Ike Chinyere, Kyle Weigand, Univ of Arizona, Tucson, AZ; Talal Moukabary, Carondelet Heart and Vascular Inst, Tucson, AZ; Russell Witte, Jordan Lancaster, Steven Goldman, Elizabeth Juneman, Univ of Arizona, Tucson, AZ I. Chinyere: None. K. Weigand: None. T. Moukabary:

None. R. Witte: None. J. Lancaster: None. S. Goldman:None. E. Juneman: None.

72 The Tumor Suppressor Gene Tip30 Supports Cardiac Compensation during Overload and Inhibits Myocardial Protein Synthesis Andrea Grund, Malgorzata Szaroszyk, Mortimer Korf-Klingebiel, Christopher Tiedje, Matthias Gaestel, Sandor Batkai, Thomas Thum, Medische Hochschule Hannover, Hannover, Germany; Andreas Jungmann, Ralf Bauer, Univsklinikum Heidelberg, Heidelberg, Germany; Xiaoke Yin, Manuel Mayr, King`s Coll, London, United Kingdom; Kai C. Wollert, Andreas Pich, Medische Hochschule Hannover, Hannover, Germany; Hua Xiao, Michigan State Univ, East Lansing, MI; Hugo A. Katus, Univsklinikum Heidelberg, Heidelberg, Germany; Johann Bauersachs, Medische Hochschule Hannover, Hannover, Germany; Oliver J Müller, Univsklinikum Heidelberg, Heidelberg, Germany; Joerg Heineke, Medische Hochschule Hannover, Hannover, Germany A. Grund: None. M. Szaroszyk: None. M. Korf-Klingebiel:

None. C. Tiedje: None. M. Gaestel: None. S. Batkai:None. T. Thum: None. A. Jungmann: None. R. Bauer:None. X. Yin: None. M. Mayr: None. K.C. Wollert: None. A.Pich: None. H. Xiao: None. H.A. Katus: None. J.Bauersachs: None. O.J. Müller: None. J. Heineke: None.

73 Yap Plays a Crucial Role in the Development of Cardiomyopathy in Lysosomal Storage Diseases SHOHEI IKEDA, Akihiro Shirakabe, Sebastiano Sciarretta, Junichi Sadoshima, Rutgers NJMS, Newark, NJ S. Ikeda: None. A. Shirakabe: None. S. Sciarretta:

None. J. Sadoshima: None.

74 Cardioprotective Effect of Growth Hormone Releasing Hormone in Mouse Model of Heart Failure with Preserved Ejection Fraction Rosemeire M Kanashiro-Takeuchi, Lauro M Takeuchi, Raul A Dulce, Darrell Hardin II, Marilia Zuttion, Wayne Balkan, Ren Z Cai, Andrew V Schally, Joshua M Hare, Univ of Miami Miller Sch of Med, Miami, FL R.M. Kanashiro-Takeuchi: None. L.M. Takeuchi:

None. R.A. Dulce: None. D. Hardin II: None. M. Zuttion:None. W. Balkan: None. R.Z. Cai: None. A.V. Schally:None. J.M. Hare: 8. Consultant/Advisory Board; Significant;Vestion.

75 Cardiomyocyte-specific Conditional Deletion of GSK-3β Leads to Global Metabolic Defects and Cardiac Dysfunction in a HFD Induced Obesity Model Hind Lal, Firdos Ahmad, Vipin K Verma, Samvruta Tumuluru, Shan Parikh, Qinkun Zhang, Thomas L Force, Vanderbilt Univ, Nashville, TN H. Lal: None. F. Ahmad: None. V.K. Verma: None. S.

Tumuluru: None. S. Parikh: None. Q. Zhang: None. T.L.Force: None.


76 Experimentally Increasing Titin’s Compliance in a Mouse Model of Heart Failure with Preserved Ejection Fraction Ameliorates Diastolic Dysfunction Mei Methawasin, Joshua G Strom, Rebecca E Slater, Vanessa Fernandez, Chandra Saripalli, Henk L Granzier, The Univ of Arizona, Tucson, AZ M. Methawasin: None. J.G. Strom: None. R.E. Slater:

None. V. Fernandez: None. C. Saripalli: None. H.L.Granzier: None.

77 Metabolic Reprograming Driven by Interaction AMP-activated Protein Kinase and Coactivator SRC-2 Regulate Cardiac Stress Response Deok Hwa Nam, Ji Ho Suh, Erin L. Reineke, Ctr for Bioenergetics, Houston Methodist Res Inst, Houston, TX D. Nam: None. J. Suh: None. E.L. Reineke: None.

78 TNFR2 Stimulation Promotes Mitochondrial Fusion via Stat3 and NF-kB Dependent Activation of OPA1 Expression Jing-Liang Nan, Wei Zhu, Ying-Chao Wang, Zhi-Wei Zhong, Lian-lian Zhu, Yan Wu, Jing Zhao, Jing-Hai Chen, Xin-Yang Hu, Hong Yu, Zhejiang Univ Sch of Med, Hangzhou, China; Mahesh Gupta, Univ of Chicago, Chicago, IL; Jian'an Wang, Zhejiang Univ Sch of Med, Hangzhou, China J. Nan: None. W. Zhu: None. Y. Wang: None. Z. Zhong:

None. L. Zhu: None. Y. Wu: None. J. Zhao: None. J. Chen:None. X. Hu: None. H. Yu: None. M. Gupta: None. J.Wang: None.

79 Sarcospan Has a Protective Effect During Development of Cardiac Disease Michelle S. Parvatiyar, Reginald T. Nguyen, Maria C. Jordan, Kenneth P. Roos, Rachelle H. Crosbie-Watson, Univ of California, Los Angeles, Los Angeles, CA

M.S. Parvatiyar: 1. Employment; Significant; UCLA. R.T.Nguyen: None. M.C. Jordan: 1. Employment; Significant;UCLA. K.P. Roos: 1. Employment; Significant; UCLA. R.H.Crosbie-Watson: 1. Employment; Significant; UCLA. 2.Research Grant; Significant; NIH RO1, MDA.


AB

ST

RA

CT

S

80 PI3Kα Regulates Biomechanical Stress-induced Cytoskeletal Remodeling: A Critical Role of Gelsolin Vaibhav B. Patel, Pavel Zhabyeyev, Brent A. McLean, Dong Fan, Ratnadeep Basu, Jessica DesAulniers, Zamaneh Kassiri, Univ of Alberta, Edmonton, AB, Canada; Bart Vanhaesebroeck, Univ Coll London, London, United Kingdom; Christopher A. McCulloch, Univ of Toronto, Toronto, ON, Canada; Gavin Y. Oudit, Univ of Alberta, Edmonton, AB, Canada V.B. Patel: None. P. Zhabyeyev: None. B.A. McLean:

None. D. Fan: None. R. Basu: None. J. DesAulniers:None. Z. Kassiri: None. B. Vanhaesebroeck: 8.Consultant/Advisory Board; Modest; Karus Therapeutics(Oxford, UK), Retroscreen (London, UK). C.A. McCulloch:None. G.Y. Oudit: None.

81 Absence of Macrophage microRNA-155 Affects Cardiac Metabolic and Inflammatory Remodeling Following Diabesotension and Protects Against Development of Heart Failure Monika Rech, Kristiaan Wouters, Julie Lecomte, Nicole Bitsch, Stephane Heymans, Marc van Bilsen, Blanche Schroen, Maastricht Univ, Maastricht, Netherlands M. Rech: None. K. Wouters: None. J. Lecomte: None. N.

Bitsch: None. S. Heymans: None. M. van Bilsen: None. B.Schroen: None.

82 Reduction of SHP2's Phosphatase Activity Improves Cardiac Adaptation to Pressure and Volume Overload Rajika Roy, Kathryn Crombie, Diana Douglas, Maike Krenz, Univ of Missouri, Dalton Cardiovascular Res Ctr, Columbia, MO R. Roy: None. K. Crombie: None. D. Douglas: None. M.

Krenz: None.

83 Autophagy Protects the Heart Against Pressure Overload Induced Heart Failure Akihiro Shirakabe, Yoshiyuki Ikeda, Toshiro Saito, Peiyong Zhai, Junichi Sadoshima, Rutgers New Jersey Medical Sch, Newark, NJ A. Shirakabe: None. Y. Ikeda: None. T. Saito: None. P.

Zhai: None. J. Sadoshima: None.


84 Remodeling of Repolarization and Arrhythmia Susceptibility in a Myosin Binding Protein C Knockout Mouse Model Amir Toib, Dexel Univ, Philadelphia, PA; Sadia Mohsin, Xiaoxiao Zhang, Chen Zhang, Constantine D Troupes, Markus Wallner, Remus M Berretta, Thomas E Sharp, Giulia Borghetti, Danielle M Trappanese, Xiongwen Chen, Steven R Houser, Temple Univ, Philadelphia, PA A. Toib: None. S. Mohsin: None. X. Zhang: None. C.

Zhang: None. C.D. Troupes: None. M. Wallner:None. R.M. Berretta: None. T.E. Sharp: None. G.Borghetti: None. D.M. Trappanese: None. X. Chen:None. S.R. Houser: None.

85 Interactions Between Cardiac Myosin Binding Protein C and Actin Contribute to the Regulation of Cardiac Contraction Sabine J van Dijk, Univ of Arizona, Tucson, AZ; Kristina Bezold Kooiker, Stanford Univ, Stanford, CA; Samantha P Harris, Univ of Arizona, Tucson, AZ S.J. van Dijk: None. K. Bezold Kooiker: None. S.P. Harris: None.


86 Compromised Sarcolemmal Membrane Repair Contributes to the Progression of Heart Failure Sayak Bhattacharya, Zhaobin Xu, Liubov Gushchina, Prasanthi Appikatla, Eric X Beck, Jenna Alloush, Ahmet Kilic, Peter J. Mohler, Paul M. Janssen, Noah Weisleder, Ohio State Univ, Columbus, OH S. Bhattacharya: None. Z. Xu: None. L. Gushchina:

None. P. Appikatla: None. E.X. Beck: None. J. Alloush:None. A. Kilic: None. P.J. Mohler: None. P.M.L. Janssen:None. N. Weisleder: 7. Ownership Interest; Significant; Co-Founder of TRIM-edicine, Inc.


87 Endothelial Nogo-B Regulates Sphingolipid Biosynthesis to Promote the Onset of Pathological Hypertrophy During Chronic Pressure Overload Yi Zhang, Weill Cornell Med, New York, NY; Yan Huang, Yale Univ Sch of Medcine, New Haven, CT; Anna Cantalupo, Weill Cornell Med, New York, NY; Paula S Azevedo, Univ of Estadual Paulista, Sao Paulo, Brazil; Mauro Siragusa, Univ Hosp Heidelberg, Heidelberg, Germany; Jacek Bielawski, Medical Univ of South Carolina, Charleston, SC; Frank J Giordano, Yale Univ Sch of Med, New Haven, CT; Annarita Di Lorenzo, Weill Cornell Med, New York, NY Y. Zhang: None. Y. Huang: None. A. Cantalupo:

None. P.S. Azevedo: None. M. Siragusa: None. J.Bielawski: None. F.J. Giordano: None. A.D. Lorenzo:None.

88 Cardiac-specific Deletion of Protein Tyrosine Phosphatase 1B Exacerbates Pressure Overload-induced Hypertrophy and Heart Failure in Mice Gerald Coulis, Alexandre Bergeron, Yanfen Shi, Montreal Heart Inst, Montreal, QC, Canada; David Labbe, Michel Tremblay, McGill Univ, Montreal, QC, Canada; Gerard Karsenty, Columbia Univ, New York, NY; Benoit Boivin, SUNY Polytechnic Inst, Albany, NY G. Coulis: None. A. Bergeron: None. Y. Shi: None. D.

Labbe: None. M. Tremblay: None. G. Karsenty: None. B.Boivin: None.

89 17beta-Estradiol-activated Estrogen Receptors Attenuate Cardiac Fibrosis Through Inhibition of Collagen I and III Expression in Female Hearts Elke Dworatzek, Charité Univsmedizin Berlin, Berlin, Germany; Shokoufeh Mahmoodzadeh, Christina Westphal, Max-Delbrueck-Ctr for Molecular Med in the Helmholtz Association, Berlin, Germany; Daniela Fliegner, Bayer Pharma AG, Wuppertal, Germany; Vera Regitz-Zagrosek, Charité Univsmedizin Berlin, Berlin, Germany E. Dworatzek: None. S. Mahmoodzadeh: None. C.

Westphal: None. D. Fliegner: None. V. Regitz-Zagrosek:None.

90 Modulation of Cardiac Fibroblast to Myofibroblast Transition by Rho-associated Kinases ROCK1 and ROCK2 Svenja Hartmann, Aline Jatho, Malte Tiburcy, Wolfram H Zimmermann, Univ Medical Ctr Goettingen, Goettingen, Germany; Anne J Ridley, King's Coll London, London, United Kingdom; Susanne Lutz, Univ Medical Ctr Goettingen, Goettingen, Germany


AB

ST

RA

CT

S

S. Hartmann: None. A. Jatho: None. M. Tiburcy:None. W.H. Zimmermann: None. A.J. Ridley: None. S.Lutz: None.

91 Genome-wide Identification and Characterization of Cardiac Hypertrophy-related Long Noncoding RNAs in Mice Zhanpeng Huang, Boston Children's Hosp, Boston, MA; Gengze Wu, Dept of Cardiology, Daping Hosp, Third Military Medical Univ, Chongqing, China; Jian-Hua Yang, RNA Information Ctr, Key Lab of Gene Engineering of the Ministry of Education, State Key Lab for Biocontrol, Sun Yat-sen Univ, Guangzhou, China; Jian Ding, Jinghai Chen, Zhiqiang Lin, Boston Children's Hosp, Boston, MA; Stavros G Drakos, Div of Cardiovascular Med, Dept of Internal Med, Univ of Utah Sch of Med, Salt Lake City, UT; Craig H Selzman, Div of Cardiothoracic Surgery, Dept of Surgery, Univ of Utah Sch of Med, Salt Lake City, UT; Jan Kyselovic, Faculty of Pharmacy, Comenius Univ, Bratislava, Slovakia; William T Pu, Boston Children's Hosp, Boston, MA; Liang-Hu Qu, RNA Information Ctr, Key Lab of Gene Engineering of the Ministry of Education, State Key Lab for Biocontrol, Sun Yat-sen Univ, Guangzhou, China; Chunyu Zeng, Dept of Cardiology, Daping Hosp, Third Military Medical Univ, Chongqing, China; Da-Zhi Wang, Boston Children's Hosp, Boston, MA Z. Huang: None. G. Wu: None. J. Yang: None. J. Ding:

None. J. Chen: None. Z. Lin: None. S.G. Drakos:None. C.H. Selzman: None. J. Kyselovic: None. W.T. Pu:None. L. Qu: None. C. Zeng: None. D. Wang: None.

92 Platelet Derived Growth Factor Receptor Alpha Signaling is Required for Cardiac Fibroblast Survival and Proliferation Malina J Ivey, Michelle D Tallquist, Univ of Hawaii, Honolulu, HI M.J. Ivey: None. M.D. Tallquist: None.

93 The Role of the Stretch-responsive Genes Mlf1 and Rnd1 for Cardiac Physiology and Pathophysiology Annika Kluge, Jost Pott, Molekulare Kardiologie, Kiel, Germany A. Kluge: None. J. Pott: None.

94 Menopausal Female Mice are Hypersensitive to Cardiovascular Disease Christiane A Danilo, Eleni Constantopoulos, Jessica N Sanchez, Dennis P Pollow, Heddwen L Brooks, Yulia Lipovka, John P Konhilas, Univ of Arizona, Tucson, AZ C.A. Danilo: None. E. Constantopoulos: None. J.N.

Sanchez: None. D.P. Pollow: None. H.L. Brooks: None. Y.Lipovka: None. J.P. Konhilas: None.

95 The Role of TGFβ Signaling in a Fibrotic cMyBP-C HCM/HF Model Qinghang Meng, Bidur Bhandary, Cincinnati Children's Hosp Medical Ctr, Cincinnati, OH; Md. Shenuarin Bhuiyan, Louisiana State Univ Health Sciences Ctr, Shreveport, LA; Hanna Osinska, Jeffrey Robbins, Cincinnati Children's Hosp Medical Ctr, Cincinnati, OH Q. Meng: None. B. Bhandary: None. M. Bhuiyan:

None. H. Osinska: None. J. Robbins: None.

96 Simvastatin Prevents TGF-β1-induced SMAD2/3 Phosphorylation Involved in Ventricular Fibrosis: Role of Protein Phosphatases Farhan Rizvi, Ctr for Integrative Res on Cardiovascular Aging (CIRCA), Aurora UW Medical Group, Milwaukee, WI; Ramail Siddiqui, Ctr for Integrative Res on Cardiovascular Aging (CIRCA), Milwaukee, WI; Alessandra DeFranco,

Alisher Holmuhamedov, Hao Xu, Larisa Emelyanova, Gracious Ross, Yang Shi, Ekhson Holmuhamedov, A. Jamil Tajik, Arshad Jahangir, Ctr for Integrative Res on Cardiovascular Aging (CIRCA), Aurora UW Medical Group, Milwaukee, WI F. Rizvi: None. R. Siddiqui: None. A. DeFranco: None. A.

Holmuhamedov: None. H. Xu: None. L. Emelyanova:None. G. Ross: None. Y. Shi: None. E. Holmuhamedov:None. A. Tajik: None. A. Jahangir: None.

97 Ca2+ Influx Via ICRAC Channels is Involved in Increased Secretion/Deposition of Collagen by Human Failing Heart Ventricular Fibroblasts Gracious R. Ross, Larisa Emelyanova, Farhan Rizvi, Yang Shi, Ekhson L. Holmuhamedov, Ctr for Integrative Res on Cardiovascular Aging (CIRCA), Aurora Health Care, Milwaukee, WI; Paul Werner, A. Jamil Tajik, Aurora Cardiovascular Services, Aurora Sinai/Aurora St. Luke's Medical Ctrs, Milwaukee, WI; Arshad Jahangir, Ctr for Integrative Res on Cardiovascular Aging (CIRCA), Aurora Health Care, Milwaukee, WI G. Ross: None. L. Emelyanova: None. F. Rizvi: None. Y.

Shi: None. E. Holmuhamedov: None. P. Werner: None. A.Tajik: None. A. Jahangir: None.

98 Profiling GPCR Expression in Cardiac Fibroblasts and Myofibroblasts Krishna Sriram, Nakon Aroonsakool, Alexander Michkov, Paul Insel, Univ of California San Diego, La Jolla, CA

K. Sriram: 2. Research Grant; Significant; Researchfunded by Bristol Myers Squibb. N. Aroonsakool: 2.Research Grant; Significant; Research funded by BristolMyers Squibb. A. Michkov: 2. Research Grant; Significant;Research funded by Bristol Myers Squibb. P. Insel: 2.Research Grant; Significant; Research funded by BristolMyers Squibb.

99 IL10-inhibits Fibroblast Progenitor Cell-mediated Cardiac Fibrosis in Pressure-overloaded Myocardium Suresh K Verma, Venkata N Garikipati, Ctr for Transnational Med, Temple Univ, Philadelphia, PA; Prasanna Krishnamurthy, Houston Methodist Res Inst, Houston, TX; Cindy Benedict, Emily Nickoloff, Raj Kishore, Ctr for Transnational Med, Temple Univ, Philadelphia, PA S.K. Verma: None. V.N.S. Garikipati: None. P. Krishnamurthy: None. C. Benedict: None. E. Nickoloff: None. R. Kishore: None.


100 Discovery of Cardiac Fibroblast Enriched microRNAs and Their Pivotal Roles in the Regulation of Cardiac Remodeling and Fibrosis Yue Zhou, Arthur Mark Richards, Peipei Wang, Cardiovascular Res Inst, Natl Univ of Singapore, Singapore, Singapore Y. Zhou: None. A.M. Richards: None. P. Wang: None.

101 Mitochondrial and Cardiac Protection Evoked by a Novel Mitochondria-targeting Peptide-idebenone Conjugate Justin B Perry, Rick J Alleman, Alvin M Tsang, William Brandon Winfrey, Mitchell E Allen, Tom D Green, Joseph M McClung, David A Brown, East Carolina Univ, Greenville, NC J.B. Perry: None. R.J. Alleman: None. A.M. Tsang: None. W.B. Winfrey: None. M.E. Allen: None. T.D. Green: None. J.M. McClung: None. D.A. Brown: 2. Research Grant; Significant; Stealth BioTherapeutics. 8.


AB

ST

RA

CT

S

Consultant/Advisory Board; Significant; Stealth BioTherapeutics.

102 Downregulation of Mitochondrial Energetics in Senescent Human Atria Larisa Emelyanova, Ctr for Integrative Res on Cardiovascular Aging (CIRCA), Aurora Univ of Wisconsin Medical Group, Aurora Health Care System, Milwaukee, WI; Anu Gupta, Viqar Maria, Div of Cardiovascular Diseases, Dept of Med, Mayo Clinic Rochester, Rochester, MN; Mohammed Yousufuddin, Div of Cardiovascular Surgery, Dept of Surgery, Mayo Clinic Rochester, Rochester, MN; Stacie Edwards, Kelsey Kraft, Ulugbek Negmadjanov, Gracious Ross, Farhan Rizvi, Yang Shi, Arshad Jahangir, Ctr for Integrative Res on Cardiovascular Aging (CIRCA), Aurora Univ of Wisconsin Medical Group, Aurora Health Care System, Milwaukee, WI L. Emelyanova: None. A. Gupta: None. V. Maria:

None. M. Yousufuddin: None. S. Edwards: None. K. Kraft:None. U. Negmadjanov: None. G. Ross: None. F. Rizvi:None. Y. Shi: None. A. Jahangir: None.

103 MCL-1Matrix Promotes Mitochondrial Fusion and ProtectsAgainst MitophagyLeonardo J Leon, Alexandra G Moyzis, Asa B Gustafsson,UCSD, San Diego, CAL.J. Leon: None. A.G. Moyzis: None. A.B. Gustafsson:

None.


104 Defective Branched-chain Amino Acid Catabolism Impairs Glucose Metabolism and Sensitizes the Heart to Ischemia/Reperfusion Injury TAO LI, Zhen Zhang, Stephen C Kolwicz, Jr., Univ of Washington, Seattle, WA; Haipeng Sun, UCLA David Geffen Sch of Med, Los Angeles, CA; Rong Tian, Univ of Washington, Seattle, WA T. Li: None. Z. Zhang: None. S. Kolwicz, Jr.: None. H.

Sun: None. R. Tian: None.

105 The Novel Heart-specific Ring-finger Protein 207 Regulates Energy Metabolism in Cardiomyocytes Wataru Mizushima, Dept of Cardiovascular Med, Hokkaido Univ Graduate Sch of Med, Sapporo, Japan; Hidehisa Takahashi, Masashi Watanabe, Dept of Biochemistry, Hokkaido Univ Graduate Sch of Med, Sapporo, Japan; Shintarou Kinugawa, Shouji Matsushima, Shingo Takada, Takashi Yokota, Takaaki Furuhata, Junichi Matsumoto, Masaya Tsuda, Takashi Katayama, Takayuki Nakajima, Dept of Cardiovascular Med, Hokkaido Univ Graduate Sch of Med, Sapporo, Japan; Shigetsugu Hatakeyama, Dept of Biochemistry, Hokkaido Univ Graduate Sch of Med, Sapporo, Japan; Hiroyuki Tsutsui, Dept of Cardiovascular Med, Hokkaido Univ Graduate Sch of Med, Sapporo, Japan W. Mizushima: None. H. Takahashi: None. M. Watanabe:

None. S. Kinugawa: None. S. Matsushima: None. S.Takada: None. T. Yokota: None. T. Furuhata: None. J.Matsumoto: None. M. Tsuda: None. T. Katayama:None. T. Nakajima: None. S. Hatakeyama: None. H.Tsutsui: 2. Research Grant; Significant; Tanabe-Mitsubishi,Daiichi-Sankyo, Takeda, Boehriner-Ingelheim, Bayer. 5.Honoraria; Modest; Boehriner-Ingelheim, Bayer, BMS,Takeda. 5. Honoraria; Significant; MSD, Tanabe-Mitsubishi,Daiichi-Sankyo, Teijin.

106 G Protein-coupled Receptor Kinase 2 Associates with Mitochondrial Proteins and Negatively Alters Mitochondrial Respiration After Myocardial Infarction Jessica Pfleger, Priscila Sato, Temple Univ, Philadelphia, PA; Kunhong Xiao, Univ of Pittsburgh, Pittsburgh, PA; Walter J. Koch, Temple Univ, Philadelphia, PA J. Pfleger: None. P. Sato: None. K. Xiao: None. W. Koch:

None.

107 Acetyl-coa Carboxylase 2 Prevents Cardiomyocyte Hypertrophy by Reducing Glucose Reliance Julia Ritterhoff, Dan Shao, Rong Tian, Univ of Washington, Seattle, WA J. Ritterhoff: None. D. Shao: None. R. Tian: None.

108 Thioredoxin-interacting Protein Interacts with Glucose Transporters to Regulate Cardiac Glucose Metabolism Bing F Wang, Ronald B Myers, Gregory M Fomovsky, Samuel Lee, Parth Patwari, Jun Yoshioka, Brigham and Women's Hosp, Harvard Medical Sch, Cambridge, MA B.F. Wang: None. R.B. Myers: None. G.M. Fomovsky: None. S. Lee: None. P. Patwari: None. J. Yoshioka: None.


109 Understanding Multi-allelic Heterozygous Variant Contributions to Cardiomyopathy Using iPSCs Cassandra Happe, Kevin Tenerelli, Dekker C. Deacon, Vivien Tran, Hermes Taylor-Weiner, Eric D. Adler, Neil C. Chi, Adam J. Engler, UC San Diego, La Jolla, CA C. Happe: None. K. Tenerelli: None. D.C. Deacon:

None. V. Tran: None. H. Taylor-Weiner: None. E.D. Adler:None. N.C. Chi: None. A.J. Engler: None.


110 The Estrogen-related Receptor Gamma Promotes Maturation of iPSC-derived Cardiac Myocytes Tomoya Sakamoto, Teresa C. Leone, Sanford Burnham Prebys Medical Discovery Inst, Orlando, FL; Huei-Sheng Vincent Chen, Sanford Burnham Prebys Medical Discovery Inst, San Diego, CA; Rick B. Vega, Daniel P. Kelly, Sanford Burnham Prebys Medical Discovery Inst, Orlando, FL T. Sakamoto: None. T.C. Leone: None. H. Chen:

None. R.B. Vega: None. D.P. Kelly: 2. Research Grant;Significant; Takeda Pharmaceutical Co..


111 Cdk5 is Associated in Cardiac Calcium Channelopathy Masayuki Yazawa, LouJin Song, Columbia Univ, New York, NY M. Yazawa: None. L. Song: None.

112 Microrna-532-5p Protects the Mouse Heart Against Myocardial Infarction by Repressing a Positive Regulator of Endothelial-to-mesenchymal Transition, Prss23 Ahmed S Bayoumi, Jian P Teoh, Il-man Kim, Augusta Univ, Augusta, GA A.S. Bayoumi: None. J.P. Teoh: None. I. Kim: None.



AB

ST

RA

CT

S

114 Downregulation of Small GTPase Rnd3 in Cardiomyocytes Leads to Hyperinflammatory Response in Post-myocardial Infarction Heart Yuan Dai, Xiangsheng Yang, Xiaojing Yue, Tingli Yang, Texas A&M Univ Health Science Ctr, Inst of Biosciences and Technology, Houston, TX; Xin Yi, Wuhan Univ Renmin Hosp, Wuhan, China; Xi Lin, Fei Wang, Jiang Chang, Texas A&M Univ Health Science Ctr, Inst of Biosciences and Technology, Houston, TX Y. Dai: None. X. Yang: None. X. Yue: None. T. Yang:

None. X. Yi: None. X. Lin: None. F. Wang: None. J. Chang:None.

115 Post-ischemic Estrogen Administration Protects the Myocardium Against Ischemia/Reperfusion Injury by Reducing Mitochondrial Protein Ubiquitination, Acetylation and Calpain10 Levels and Inhibition of the mPTP Opening via GPER1 Activation Yansheng Feng 78229, Ngonidzashe Benson Madungwe, Mohammad Enamul Kabir, Jean C. Bopassa, UTHSCSA, San Antonio, TX Y. Feng: None. N. Madungwe: None. M. Kabir: None. J.

Bopassa: None.


116 Loss of T-type Ca2+ Channels Alters the Cardiac Response to Myocardial Infarction Shavonn C Harper, Tao Wang, Yijun Yang, Steven R Houser, Temple Univ Sch of Med, Philadelphia, PA S.C. Harper: None. T. Wang: None. Y. Yang: None. S.R.

Houser: None.

117 Poly (i:c) Attenuates Myocardial I/R Injury via Glycolytic Dependent Yap Activation and by Suppression of MiR-143 Yuanping Hu, Xiaohui Wang, Tuanzhu Ha, John Kalbfleisch, Race Kao, David Williams, Chuanfu Li, East Tennessee State Univ, Johnson City, TN Y. Hu: None. X. Wang: None. T. Ha: None. J. Kalbfleisch:

None. R. Kao: None. D. Williams: None. C. Li: None.

119 Tempol Pre-treatment Restores Isoflurane Preconditioning in the Aged Cardiomyocytes: Involvement of Pink1/Parkin-mediated Mitophagy Li Ma, Qun Gao, Mario J Rebecchi, Lixin Liu, Stony Brook Univ, Sch of Med, Stony Brook, NY L. Ma: None. Q. Gao: None. M.J. Rebecchi: None. L. Liu:

None.

120 HIF1 Alpha Can be Inhibited in the Heart by Protein Kinase C Binding Protein 1 Kathryn J Schunke, Karen H Chang, Chad B Walton, Ralph V Shohet, Univ of Hawaii, Honolulu, HI K.J. Schunke: None. K.H. Chang: None. C.B. Walton: None. R.V. Shohet: None.

121 Metabolic Regulation of Ischemia/Reperfusion: Role of the Unfolded Protein Response Zhao Wang, UT Southwestern Medical Ctr, Dallas, TX Z. Wang: None.


122 Pkialpha Protects Hearts from Beta-adrenergic Overstimulation Xiaoying Zhang, Ying Li, Xiaojie Ai, Mingxin Tang, Christopher Szeto, Xiang Hua, Xiongwen Chen, Temple Univ, Philadelphia, PA

X. Zhang: 2. Research Grant; Significant; AHA SDG. Y. Li:None. X. Ai: None. M. Tang: None. C. Szeto: None. X.Hua: None. X. Chen: None.


123 Adenoviral RhoA Regulation of Dynamin-related Protein 1 and Cardiac Mitochondrial Fission Cameron S Brand, Valerie P Tan-Sah, Joan Heller Brown, Shigeki Miyamoto, UC San Diego, La Jolla, CA C.S. Brand: None. V.P. Tan-Sah: None. J. Heller Brown:

None. S. Miyamoto: None.

124 Integrated Omics Approaches to Elucidate Targets of Cyclic AMP-Epac-Rap1A Signaling in Microvascular Smooth Muscle Cells: Identification of Role in Production and Deposition of Extracellular Matrix Fibrillar Collagen Maqsood A. Chotani, [1] Intl Ctr for Chemical & Biological Sciences, Dr. Panjwani Ctr for Molecular Med & Drug Res, Univ of Karachi, Karachi, Pakistan M.A. Chotani: None.

125 Role of 14-3-3eta Protein in the Heart During Aging: Involvement of MAPK Mediated Endoplasmic Reticulum Signaling in Senescence-accelerated Prone Mice Vijayasree V Giridharan, The Univ of Texas Health Science Ctr at Houston, Houston, TX; Remya Sreedhar, Somasundaram Arumugam, VengadeshPrabu Karuppagounder, Niigata Univ of Pharmacy and Applied Life Sciences, Niigata, Japan; Suresh S Palaniyandi, Div of Hypertension and Vascular Res, Henry Ford Health System, Detroit, MI; Prasanna Krishnamurthy, Houston Methodist Res Inst, Houston, TX; Joao L DeQuevedo, The Univ of Texas Health Science Ctr at Houston, Houston, TX; Kenichi Watanabe, Tetsuya Konishi, Niigata Univ of Pharmacy and Applied Life Sciences, Niigata, Japan; Rajarajan A Thandavarayan, Houston Methodist Res Inst, Houston, TX V.V. Giridharan: None. R. Sreedhar: None. S.

Arumugam: None. V. Karuppagounder: None. S.S.Palaniyandi: None. P. Krishnamurthy: None. J.L.DeQuevedo: None. K. Watanabe: None. T. Konishi:None. R.A. Thandavarayan: None.


AB

ST

RA

CT

S

126 Triptonide is an Effective Inhibitor of Wnt Signaling Jijun Hao, Jessica Chinison, Jose S Aguilar, Alan Avalos, Ying Huang, Moses Chow, Joshua Cameron, Western Univ of Health Sciences, Pomona, CA J. Hao: None. J. Chinison: None. J.S. Aguilar: None. A.

Avalos: None. Y. Huang: None. M. Chow: None. J.Cameron: None.

127 Phosphorylation of Serum Responsive Factor by p90 Ribosomal S6 Kinase 3 Promotes Concentric Growth of Cardiac Myocytes Jinliang Li, Eliana C Martinez Valencia, Catherine L Passariello, Hrishikesh Thakur, Michael Kapiloff, Univ of Miami, Miami, FL

J. Li: 1. Employment; Significant; Dr. Li is an employee ofAnchored RSK3 Inhibitors, LLC. 7. Ownership Interest;Significant; Dr. Li is a co-inventor of RSK3 related IP. E.C.Martinez Valencia: None. C.L. Passariello: 7. OwnershipInterest; Significant; Dr. Passariello is a co-inventor ofintellectual property relating to RSK3 and heart failure. H.Thakur: None. M. Kapiloff: 7. Ownership Interest;Significant; Dr. Kapiloff is the Manager of Anchored RSK3Inhibitors, LLC, and President of Cardiac RSK3 Inhibitors,LLC, companies interested in developing RSK3 targetedtherapies.. 9. Other; Significant; Dr. Kapiloff is a co-inventorof intellectual property concerning the use of RSK3 inhibitorsfor the treatment of heart failure.

128 Impaired Beta Adrenergic Receptor Resensitization Contributes to Human Heart Failture Elizabeth E. Martelli, Arunachal Chatterjee, Maradumane M. Mohan, John George, Randall Starling, ChristineMoravec, Sathyamangla V. Naga Prasad, Cleveland Clinic,Cleveland, OHE.E. Martelli: None. A. Chatterjee: None. M.M. Mohan:

None. J. George: None. R. Starling: None. C. Moravec:None. S.V. Naga Prasad: None.


129 Transient Activation of AMPK Prior to Cardiac Pressure Overload Alleviates Fibrotic Accumulation and Functional Decline Erin L Reineke, Houston Methodist Res Inst, Houston, TX; George E Taffet, Jason T Kaelber, Baylor Coll of Med, Houston, TX; Heinrich Taegtmeyer, Univ of Texas Medical Sch at Houston, Houston, TX; Mark L Entman, Bert W O'Malley, Baylor Coll of Med, Houston, TX E.L. Reineke: None. G.E. Taffet: None. J.T. Kaelber:

None. H. Taegtmeyer: None. M.L. Entman: None. B.W.O'Malley: None.

130 Arginine Methylation of Smad6 Defines Bone-morphogenetic-protein (BMP) Signaling Duration and Intensity JIAN WU, Olan Jackson-Weaver, Tingwei Zhang, Yongchao Gou, Jian Xu, Univ of Southern California, Los Angeles, CA J. Wu: None. O. Jackson-Weaver: None. T. Zhang:

None. Y. Gou: None. J. Xu: None.


131 PDE1 Inhibition Improves Cardiac Protein Quality Control Hanming Zhang, Xuejun "XJ" Wang, Sanford Sch of Med of the Univ of South Dakota, Vermillion, SD H. Zhang: None. X. Wang: None.


132 A Novel Hydrogen Sulfide (H2S) Prodrug, SG1002, Protects Against Myocardial Oxidative Damage and Hypertrophic Signaling via Induction of Cystathionine Β-Synthase (CBS) and Antioxidant Proteins Kazi N Islam, Erminia Donnarumma, Erinn Donnelly, David J Lefer, LSU Health Sciences Ctr, New Orleans, LA K.N. Islam: 2. Research Grant; Modest; COBRE NIGMS 1P30GM106392. E. Donnarumma: None. E. Donnelly: None. D.J. Lefer: None.

133 A Systems Genetics Approach to Identify Genetic Pathways and Key Drivers of Isoproterenol-induced Cardiac Hypertrophy and Cardiomyopathy in Mice Christoph D Rau, Milagros Romay, Jessica Wang, Aldons J Lusis, Yibin Wang, UCLA, Los Angeles, CA C.D. Rau: None. M. Romay: None. J. Wang: None. A.J.

Lusis: None. Y. Wang: None.


134 Increased Ca2+ Influx Through Cav1.2 in Vascular Smooth Muscle Cells Causes Hypertension Due to Impairment of Acetylcholine-dependent Vascular Relaxation xiaoying Zhang, Zhongjian Cheng, Xiaojie Ai, Mingxin Tang, Xiang Hua, Steven R Houser, Temple Univ, Philadelphia, PA; Manuel F Navedo, Univ of California at Davis, Philadelphia, PA; Luis F Santana, Univ of California at Davis, Davis, CA; Hong Wang, Xiongwen Chen, Temple Univ, Philadelphia, PA X. Zhang: None. Z. Cheng: None. X. Ai: None. M. Tang:

None. X. Hua: None. S.R. Houser: None. M.F. Navedo:None. L.F. Santana: None. H. Wang: None. X. Chen:None.


135 Thoracic Aortic Wall Tension Regulates microRNA-133a Abundance Adam W Akerman, Elizabeth K Nadeau, Robert E Stroud, Rupak Mukherjee, John S Ikonomidis, Jeffery A Jones, Medical Univ of South Carolina, Charleston, SC A.W. Akerman: None. E.K. Nadeau: None. R.E. Stroud: 2. Research Grant; Significant; R01 AG036954, R01 HL102121, IO1 BX000904, I21 RX001707. R. Mukherjee: 2. Research Grant; Significant; R01 AG036954, R01 HL102121, IO1 BX000904, I21 RX001707. J.S. Ikonomidis: 2. Research Grant; Significant; R01 AG036954, R01HL102121, IO1 BX000904, I21 RX001707. J.A. Jones: 2.Research Grant; Significant; R01 AG036954, R01HL102121, IO1 BX000904, I21 RX001707.

136 Cytoplasmic Histone Deacetylase 4 Promotes Vascular Calcification Alon Abend Bsc, Omer Shkedi, Michal Fertouk, Lilac Caspi, Izhak Kehat, Technion Israel Inst Technolog, Haifa, Israel A. Abend: None. O. Shkedi: None. M. Fertouk: None. L.

Caspi: None. I. Kehat: None.

137 Ctcf is Essential for Transcriptome Regulation in the Healthy Heart Manuel Rosa-Garrido, Todd Kimball, Douglas J Chapski, Tsai-Ting Shih, Elizabeth Soehalim, Enrique Balderas, UCLA, Los Angeles, CA; Niels J Galjart, Erasmus MC,


AB

ST

RA

CT

S

Rotterdam, Netherlands; Yibin Wang, Thomas M Vondriska, UCLA, Los Angeles, CA M. Rosa-Garrido: None. T. Kimball: None. D.J. Chapski: None. T. Shih: None. E. Soehalim: None. E. Balderas: None. N.J. Galjart: None. Y. Wang: None. T.M. Vondriska: None.

This research has received full or partial funding support from the American Heart Association. 138 Inhibition of Stress-inducible Genes That Distinguish Pathological Cardiac Hypertrophy via Targeting Acidic Nuclear Protein 32e Hyewon Shin, Zhi Yang, Minzhen He, Danish Sayed, Maha Abdellatif, Rutgers Univ Cellular Biology and Molecular Med, Newark, NJ H. Shin: None. Z. Yang: None. M. He: None. D. Sayed: None. M. Abdellatif: None. 139 Role of Histone Lysine Demethylase PHF8 in Epigenetic Regulation of Embryonic Stem Cell Cardiac Differentiation Yan Tang, Yujia Yue, Suresh K Verma, Mohsin Khan, Raj Kishore, Temple Univ, Philadelphia, PA Y. Tang: None. Y. Yue: None. S.K. Verma: None. M. Khan: None. R. Kishore: None. 140 BMI- and Gender-specific Increase of MAP2K3/p38 Activity in Human Cardiac Hypertrophy Mackenzie Newman, Aniello M Infanto, West Virginia Univ, Morgantown, WV; Michael J Watson, Duke Univ, Durham, NC; Robert W Hull, Han-Gang Yu, West Virginia Univ, Morgantown, WV M. Newman: None. A.M. Infanto: None. M.J. Watson: None. R.W. Hull: None. H. Yu: 2. Research Grant; Modest; AHA.

This research has received full or partial funding support from the American Heart Association. 200 Role of Silent Mating Type Information Regulation 2 Homolog - 6 in Wound Healing in Diabetes Rajarajan Amirthalingam Thandavarayan, Darukeshwara Joladarashi, Prince Jeyabal, Sahana Suresh Babu, Houston Methodist Res Inst, Houston, TX; Suresh K Verma, Garikipati Venkata Naga Srikanth, Mohsin Khan, Raj Kishore, Ctr for Translational Med, Temple Univ Sch of Med, Philadelphia, PA; Prasanna Krishnamurthy, Houston Methodist Res Inst, Houston, TX R. Amirthalingam Thandavarayan: None. D. Joladarashi: None. P. Jeyabal: None. S. Suresh Babu: None. S. K Verma: None. G. Venkata Naga Srikanth: None. M. Khan: None. R. Kishore: None. P. Krishnamurthy: None.

This research has received full or partial funding support from the American Heart Association. 201 A Novel Contrast Agent - Magnetic Iodixanol Mark C Arokiaraj, Pondicherry Inst of Medical Sciences, Pondicherry, India M.C. Arokiaraj: None. 202 Early Reprogramming Derived Cocktail FIJs Supports Cardiomyocyte Proliferation for Heart Regeneration Yuan-Yuan Cheng, Inst of Biomedical Sciences (Academia Sinica), Taipei, Taiwan Y. Cheng: None.

203 A Shh Coreceptor Cdo is Required for Efficient Cardiomyogenesis of Pluripotent Stem Cells Myong-Ho Jeong, Young-Eun Leem, Hyun-Ji Kim, Kyungjin Kang, Hana Cho, Jong-Sun Kang, Sungkyunkwan Univ Sch of Med, Suwon, Korea, Republic of M. Jeong: None. Y. Leem: None. H. Kim: None. K. Kang: None. H. Cho: None. J. Kang: None. 204 Serine Threonine Kinase-35 Regulates Diabetes-induced Endothelial Progenitor Cells Dysfunction Darukeshwara Joladarashi, Rajarajan A. Thandavarayan, Sahana Suresh Babu, Prince Jeyabal, Houston Methodist Res Inst, Houston, TX; Raj Kishore, Ctr for Translational Med, Philadelphia, PA; Prasanna Krishnamurthy, Houston Methodist Res Inst, Houston, TX D. Joladarashi: None. R. Thandavarayan: None. S. Suresh Babu: None. P. Jeyabal: None. R. Kishore: None. P. Krishnamurthy: None. 205 Feasibility and Testing of a Human Induced Pluripotent Stem Cell Derived Cardiac Patch in a Pre-clinical Swine Model of CHF Jordan J Lancaster, Ike Chinyere, Bin Na Kim, Sherry Daugherty, Samuel Kim, Clint Jokerst, Ryan Avery, Brandon Larson, Univ of Arizona, Tucson, AZ; Laryenth D Lancaster, Pima Heart, Tucson, AZ; Elizabeth Juneman, Steven Goldman, Univ of Arizona, Tucson, AZ J.J. Lancaster: None. I. Chinyere: None. B. Kim: None. S. Daugherty: None. S. Kim: None. C. Jokerst: None. R. Avery: None. B. Larson: None. L.D. Lancaster: None. E. Juneman: None. S. Goldman: None. 206 Stem Cell-derived Exosomes Induce Cardiac Repair via mRNA Modification Prabhu Mathiyalagan, Yaxuan Liang, Adriano S Martins, Douglas W Losordo, Roger J Hajjar, Susmita Sahoo, Icahn Sch of Med at Mount Sinai, New York, NY P. Mathiyalagan: None. Y. Liang: None. A.S. Martins: None. D.W. Losordo: None. R.J. Hajjar: None. S. Sahoo: None.

This research has received full or partial funding support from the American Heart Association. 207 Electrically-induced Calcium Handling in Human Cardiac Progenitor Cells Joshua T. Maxwell, Mary B. Wagner, Michael E. Davis, Emory Univ, Atlanta, GA J.T. Maxwell: None. M.B. Wagner: None. M.E. Davis: None. 208 miR-34a Regulates the Functional Activity of Human Cardiac Progenitor Cells During Chronological Age Rachana Mishra, Wen Chih Cheng, Sudhish Sharma, Tami Kingsbury, Curt I Civin, Sunjay Kaushal, Univ of Maryland, Baltimore, MD R. Mishra: None. W.C. Cheng: None. S. Sharma: None. T. Kingsbury: None. C. Civin: None. S. Kaushal: None. 209 Exosomes Derived From c-kit+ Cardiac Progenitor Cells are Essential for Myocardial Repair After Acute Myocardial Function Sudhish Sharma, Grace E Bigham, Rachana Mishra, Univ of Maryland, Baltimore, MD; Flaviu Gruia, Medimmune Inc, Gathithesburg, MD; Philip Zachary Brohawn, Sotirios Karanthasis, Medimmune Inc, Gaithesburg, MD; Sunjay Kaushal, Univ of Maryland, Baltimore, MD


AB

ST

RA

CT

S

S. Sharma: None. G.E. Bigham: None. R. Mishra: None. F. Gruia: None. P.Z. Brohawn: None. S. Karanthasis: None. S. Kaushal: None. 210 Mesenchymal Stem Cells Reduce Neutrophil Mediated Inflammation Following Myocardial Ischemia-reperfusion Injury Eric Shin, Marina Zemskova, Lanfang Wang, Rabin Tirouvanziam, Emory Univ, Atlanta, GA; Andres Garcia, Georgia Inst of Technology, Atlanta, GA; William R Taylor, Rebecca Levit, Emory Univ, Atlanta, GA E. Shin: None. M. Zemskova: None. L. Wang: None. R. Tirouvanziam: None. A. Garcia: None. W.R. Taylor: None. R. Levit: None.

This research has received full or partial funding support from the American Heart Association. 211 ATF6 and the Adaptive ER Stress Response Enhances Proliferation and Viability in Mouse Cardiac Stem Cells Winston T Stauffer, San Diego State Univ, San Diego, CA; Shirin Doroudgar, Heidelberg Univ Hosp, Heidelberg, Germany; Haley N Stephens, Brandi Bailey, Christopher C Glembotski, San Diego State Univ, San Diego, CA W.T. Stauffer: None. S. Doroudgar: None. H.N. Stephens: None. B. Bailey: None. C.C. Glembotski: None.

This research has received full or partial funding support from the American Heart Association. 212 Aggregation of Child Cardiac Progenitor Cells into 3D Spheres Improves Endothelial Lineage Commitment David Q Trac, Wallace H. Coulter Dept of Biomed Eng, Georgia Inst of Technology & Emory Univ Sch of Med, Atlanta, GA; Chunhui Xu, Div of Pediatric Cardiology, Dept of Pediatrics, Emory Univ Sch of Med; Children's Heart Res & Outcomes (HeRO) Ctr, Children's Healthcare of Atlanta & Emory Univ, Atlanta, GA; Michael E. Davis, Wallace H. Coulter Dept of Biomed Eng, Georgia Inst of Technology & Emory Univ Sch of Med; Div of Pediatric Cardiology, Dept of Pediatrics, Emory Univ Sch of Med; Children's Heart Res & Outcomes (HeRO) Ctr, Children's Healthcare of Atlanta & Emory Univ, Atlanta, GA D.Q. Trac: None. C. Xu: None. M. Davis: None. 213 Evolving Challenges in Promoting Stem Cell Based Cardiovascular Repair and Regeneration Mani T Valarmathi, Jiang Li, Univ of Illinois at Urbana-Champaign, Urbana, IL M.T. Valarmathi: None. J. Li: None.

This research has received full or partial funding support from the American Heart Association. 214 TLR3 Mediates Neonatal Heart Repair and Regeneration Through Glycolysis-dependent YAP/TAZ Mediated miR-152 Expression Xiaohui Wang, Yuanping Hu, Tuanzhu Ha, John Kalbfleisch, Race Kao, David Williams, Chuanfu Li, East Tennessee State Univ, Johnson City, TN X. Wang: None. Y. Hu: None. T. Ha: None. J. Kalbfleisch: None. R. Kao: None. D. Williams: None. C. Li: None. 215 Heart Regeneration with Cardiac Progenitor Cells and Engineered ECM Mimicking Carriers in Large Animal Models Shuo Tian, Dept of Cardiac Surgery, Univ of Michigan, Ann Arbor, MI; Qihai Liu, 2Dept of Biologic and Materials Sciences, Univ of Michigan, Ann Arbor, MI; Liangxue Lai, Guangzhou Inst of Biomedicine and Health, Chinese Acad of

Sciences, Guangzhou, China; Peter X. MA, 2Dept of Biologic and Materials Sciences, Univ of Michigan, Ann Arbor, MI; Zhong Wang, Dept of Cardiac Surgery, Univ of Michigan, Ann Arbor, MI S. Tian: None. Q. Liu: None. L. Lai: None. P.X. Ma: None. Z. Wang: None. 216 Intra-myocardial Injection of a Novel Thermosensitive Hydrogel Inhibits Post-infarct Heart Failure in Rats Ying Wen, Xiao-yan Li, Dept of Cardiology, Renmin Hosp of Wuhan Univ, Wuhan, China; Ze-yong Li, Key Lab of Biomedical Polymers of Ministry of Education, Dept of Chemistry, Wuhan Univ, Wuhan, China; Meng-long Wang, Dept of Cardiology, Renmin Hosp of Wuhan Univ, Wuhan, China; Xian-zheng Zhang, Key Lab of Biomedical Polymers of Ministry of Education, Dept of Chemistry, Wuhan Univ, Wuhan, China; Xue-jun Jiang, Dept of Cardiology, Renmin Hosp of Wuhan Univ, Wuhan, China Y. Wen: None. X. Li: None. Z. Li: None. M. Wang: None. X. Zhang: None. X. Jiang: None. 217 Long Non-coding RNA Myocardial Infarction-associated Transcript (MIAT) Protects Cardiac Progenitor Cells From Oxidative Stress-induced Cell Death Liu Yang, Yang Yu, Baron Arnone, Chan Boriboun, Jiawei Shi, Gangjian Qin, Feinberg Cardiovascular Res Inst, Northwestern Univ, Chicago, IL L. Yang: None. Y. Yu: None. B. Arnone: None. C. Boriboun: None. J. Shi: None. G. Qin: None.

This research has received full or partial funding support from the American Heart Association. 218 Cardiac Side Population Cells Give Rise to Cardiomyocytes in the Adult Heart Amritha Yellamilli, Ingrid Bender, Yi Ren, Jop H. van Berlo, Univ of Minnesota, Minneapolis, MN A. Yellamilli: None. I. Bender: None. Y. Ren: None. J.H. van Berlo: None. 219 Induced Pluripotent Stem Cells as a Potential Cell Source for Tissue Engineered Heart Valves Aline L Yonezawa, Georgia Inst of Technology, Atlanta, GA; Monalisa Singh, Children's Heart Res and Outcomes Ctr, Atlanta, GA; David Safranski, Kenneth M Dupont, MedShape Inc., Atlanta, GA; Chunhui Xu, Children's Heart Res and Outcomes Ctr, Atlanta, GA; Michael E Davis, Georgia Inst of Technology, Atlanta, GA A.L. Yonezawa: None. M. Singh: None. D. Safranski: 1. Employment; Significant; Medshape Inc. K.M. Dupont: 1. Employment; Significant; Medshape Inc. C. Xu: None. M.E. Davis: None. 220 Epigenetic Reprogramming Rescues Diabetic Endothelial Progenitor Cell Dysfunctions and Enhances Their Reparative Activities in Ischemic Tissue Repair Jibin Zhou, Venkata Naga Garikipati, Cheng Zhongjian, Cindy Benedict, Emily Nickoloff, Erhe Gao, Suresh Verma, Mohsin Khan, Raj Kishore, Temple Univ, Philadelphia, PA J. Zhou: None. V.N.S. Garikipati: None. C. Zhongjian: None. C. Benedict: None. E. Nickoloff: None. E. Gao: None. S. Verma: None. M. Khan: None. R. Kishore: None. 221 Sam68 Interacts With mTORC1 and Contributes to Myocardial Hypertrophy Junlan Zhou, Chan Boriboun, Gangjian Qin, Northwestern Univ, Chicago, IL J. Zhou: None. C. Boriboun: None. G. Qin: None.


AB

ST

RA

CT

S

This research has received full or partial funding support from the American Heart Association. 222 Sigmar1 Mediates Mitochondrial Autophagy and Protects the Heart Against Ischemia/Reperfusion Injury Md. Shenuarin Bhuiyan, Shafiul Alam, Jonette M. Green, A. Wayne Orr, LSU Health Sciences Ctr-Shreveport, Shreveport, LA; Jeanne James, Hanna Osinska, Jason Karch, Jeffery D. Molkentin, Burns C. Blaxall, Cincinnati Children's Hosp Medical Ctr, Cincinnati, OH; John N. Lorenz, Univ of Cincinnati Coll of Med, Cincinnati, OH; Junichi Sadoshima, Rutgers New Jersey Medical Sch, Newark, NJ; Jeffrey Robbins, Cincinnati Children's Hosp Medical Ctr, Cincinnati, OH M. Bhuiyan: None. S. Alam: None. J. Green: None. A. Orr: None. J. James: None. H. Osinska: None. J. Karch: None. J. Molkentin: None. B. Blaxall: None. J. Lorenz: None. J. Sadoshima: None. J. Robbins: None. 223 Parkin is Critical for the Clearance of Damaged Mitochondria via an Autophagy-independent Pathway Babette C Hammerling, Melissa Q Cortez, Rita H Najor, Åsa B Gustafsson, UCSD, La Jolla, CA B.C. Hammerling: None. M.Q. Cortez: None. R.H. Najor: None. Å.B. Gustafsson: None.

This research has received full or partial funding support from the American Heart Association. 224 LAMP-2 Deficiency Promotes Mitochondrial Damage in Danon Disease Sherin Hashem, Emily Gault, Anne Murphy, Neil Chi, Eric Adler, Univ of California San Diego, La Jolla, CA S. Hashem: None. E. Gault: None. A. Murphy: None. N. Chi: None. E. Adler: None. 225 Assessing Sunitinib Cardiotoxicity Using Engineered Cardiac Microtissues Rachel E Truitt, Bonnie Ky, Kenneth B Margulies, Univ of Pennsylvania, Philadelphia, PA R.E. Truitt: None. B. Ky: None. K.B. Margulies: None. 226 δ-opioid Receptor Activation Protects the Brain From Hypoxic-ischemic Injury by Downregulating Inflammatory Cytokines and Upregulating Nrf-2 Jie Qiu, Dongman Chao, Univ of Texas McGovern Medical Sch, Houston, TX; Guanghong Ding, Shanghai Key Lab of Acupuncture Mechanism and Acupoint Function, Fudan Univ, Shanghai, China; Ying Xia, Univ of Texas Medical Sch at Houston, Houston, TX J. Qiu: None. D. Chao: None. G. Ding: None. Y. Xia: None. 227 Single-blind Study of Q-sweat in Postural Orthostatic Tachycardia Syndrome (POTS) Muhammad Mubashir Ahsan, Chandralekha Ashangari, Amer Suleman, The Heartbeat Clinic, Dallas, TX M.M. Ahsan: None. C. Ashangari: None. A. Suleman: None. 228 HYQVIA in Postural Orthostatic Tachycardia Syndrome (POTS) Muhammad Mubashir Ahsan, Chandralekha Ashangari, Amer Suleman, The Heartbeat Clinic, Dallas, TX M.M. Ahsan: None. C. Ashangari: None. A. Suleman: None.

229 Increased Afterload Following Myocardial Infarction Promotes Conduction-dependent Arrhythmias That are Unmasked by Hypokalemia Lukas J Motloch, Kiotake Ishikawa, Chaoqin Xie, Jun Hu, Jaume Aguero, Kenneth R Fish, Roger J Hajjar, Fadi G Akar, Icahn Sch of Med at Mount Sinai, New York, NY L.J. Motloch: None. K. Ishikawa: None. C. Xie: None. J. Hu: None. J. Aguero: None. K.R. Fish: None. R.J. Hajjar: None. F.G. Akar: None.

This research has received full or partial funding support from the American Heart Association. 230 Humoral Immune Response Against Trypanosoma cruzi Infection Using Plasmid DNA Immunotherapy in the Experimental Canine Model of Chagas Disease Silvia C Carrillo-Sanchez, Mariana Martinez-Cruz, Olivia Rodriguez-Morales, Minerva Arce-Fonseca, Insto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico S.C. Carrillo-Sanchez: None. M. Martinez-Cruz: None. O. Rodriguez-Morales: None. M. Arce-Fonseca: None. 231 Improving Physical and Mental Health Through a Community-based, Multi-disciplinary Obesity Reduction Program Promoting Social Support and Adherence Mark Lemstra, Univ of Saskatchewan, Saskatoon, SK, Canada M. Lemstra: None. 232 Restless Leg Syndrome and its Association with Iliofemoral Venous Disease Navya Reddy, Univ of Missouri Kansas City, Kansas City, MO; Nagender Reddy, Loren Heart and Vascular, Ocala, FL N. Reddy: None. N. Reddy: None. 233 DJ-1 Gene Therapy Opposes the Development of Ischemic Heart Failure Yuuki Shimizu, Dept of Surgery, Emory Univ Sch of Med, Atlanta, GA; Di Sha, Lih-Shen Chin, Lian Li, Dept of Pharmacology, Emory Univ Sch of Med, Atlanta, GA; John Calvert, Dept of Surgery, Emory Univ Sch of Med, Atlanta, GA Y. Shimizu: None. D. Sha: None. L. Chin: None. L. Li: None. J. Calvert: None. 234 Physiological Toxicity Assessment of Tyrosine Kinase Inhibitors with Human Induced Pluripotent Stem Cell Cardiomyocytes Jayna Stohlman, Derek Schocken, Jose Vicente, Dulciana Chan, Lars Johannesen, Food and Drug Admin, Silver Spring, MD; Xiaoyu Zhang, Yama Abassi, ACEA Biosciences, San Diego, CA; David Strauss, Ksenia Blinova, Food and Drug Admin, Silver Spring, MD J. Stohlman: None. D. Schocken: None. J. Vicente: None. D. Chan: None. L. Johannesen: None. X. Zhang: 1. Employment; Significant; ACEA Biosciences. Y. Abassi: 1. Employment; Significant; ACEA Biosciences. D. Strauss: None. K. Blinova: None. 235 Integration of Patient-specific Computational Hemodynamics and Vessel Wall Shear Stress Into MRI Diagnosis of Vascular Diseases Huidan Whitney Yu, Xi Chen, Zhiqiang Wang, Rou Chen, Indiana Univ-Purdue Univ, Indianapolis, Indianapolis, IN; Chen Lin, Stephen F. Kralik, Sch of Med, Indiana Univ, Indianapolis, IN; Raveena Patil, Indiana Univ-Purdue Univ, Indianapolis, Indianapolis, IN


AB

ST

RA

CT

S

H.W. Yu: None. X. Chen: None. Z. Wang: None. R. Chen: None. C. Lin: None. S.F. Kralik: None. R. Patil: None. 236 Myocardial Relaxation is Modified by Fast Stretch but not Titin Isoform Size Charles S Chung, Wayne State Univ, Detroit, MI C.S. Chung: None.

This research has received full or partial funding support from the American Heart Association. 237 Transient Activation of Pkc Results in Long-lasting Detrimental Effects on Systolic [ca2+]I in Cardiomyocytes by Altering Actin Cytoskeletal Dynamics and T-tubule Integrity Ang Guo, Long-Sheng Song, Biyi Chen, Univ of Iowa, Iowa City, IA; Rong Chen, Shanghai General Hosp, Shanghai Jiao Tong Univ Sch of Med, Shanghai 200080, China; Chunkai Huang, Yihui Wang, Shanghai General Hosp, Shanghai Jiao Tong Univ Sch of Med, Shanghai, China A. Guo: None. L. Song: None. B. Chen: None. R. Chen: None. C. Huang: None. Y. Wang: None.

This research has received full or partial funding support from the American Heart Association. 238 Loss of AKAP150 Promotes Pathological Remodeling and Heart Failure Propensity by Disrupting Calcium Homeostasis and Contractile Reserve Lei Li, Jing Li, Benjamin Drum, Yi Chen, Haifeng Yin, Xiaoyun Guo, Univ of Washington, Seattle, WA; Stephen Luckey, Seattle Univ, Seattle, WA; Merle Gilbert, G. Stanley McKnight, John Scott, Univ of Washington, Seattle, WA; Luis F. Santana, Univ of California, Davis, CA; Qinghang Liu, Univ of Washington, Seattle, WA L. Li: None. J. Li: None. B. Drum: None. Y. Chen: None. H. Yin: None. X. Guo: None. S. Luckey: None. M. Gilbert: None. G.S. McKnight: None. J. Scott: None. L.F. Santana: None. Q. Liu: None. 239 Sex and 17-beta Estradiol Regulate the Nuclear Translocation of the Cardiac L-type Calcium Channel C-terminus Shokoufeh Mahmoodzadeh, Hannelore Haase, Anje Sporbert, Ingo Morano, Max-Delbrueck-Ctr for Molecular Med in the Helmholtz Association, Molecular Muscle Physiology, Berlin, Germany S. Mahmoodzadeh: None. H. Haase: None. A. Sporbert: None. I. Morano: None. 240 Differential Impact of RBFox Family Proteins in Adult Murine Heart Chen Gao, Shuxun Ren, UCLA, Los Angeles, CA; Yibin Wang, Div of Molecular Med, UCLA, Los Angeles, CA C. Gao: None. S. Ren: None. Y. Wang: None. 241 MDM2 E3 Ligase-mediated Ubiquitination and Degradation of HDAC1 in Vascular Calcification Hyun Kook, Duk-Hwa Kwon, Gwang Hyeon Eom, Hyun-Ki Min, Somy Yoon, Yong Sook Kim, Youngkeun Ahn, Chonnam Natl Univ Medical Sch, Gwangju, Korea, Republic of H. Kook: None. D. Kwon: None. G. Eom: None. H. Min: None. S. Yoon: None. Y. Kim: None. Y. Ahn: None.

242 Priming for Action: Interventions That Promote IKs-Channel Opening Restore Defective cAMP-Dependent Upregulation in Long-QT1 Syndrome Paul G Volders, Roel L Spätjens, Sandrine R Seyen, Gabriele Menini, Cristina Moreno Vadillo, Maastricht Univ / CARIM, Maastricht, Netherlands P.G.A. Volders: None. R.L.H. Spätjens: None. S.R.M. Seyen: None. G. Menini: None. C. Moreno Vadillo: None. 243 A Novel PRKAG2 Mutation (K475E): Infantile-onset Hypertrophic Cardiomyopathy Phenotype and Impact on mTOR Signaling Yanchun Xu, Women & Infants Hosp RI, Providence, RI; Hong Liu, Cardiovascular Res Ctr and Cardiovascular Inst of Lifespan, Providence, RI; Chanika Phornphutkul, Hasbro Children’s Hosp, Providence, RI; D. Grahame Hardie, Coll of Life Sciences, Univ of Dundee, Scotland, United Kingdom; SC Jr Dudley, Cardiovascular Res Ctr and Cardiovascular Inst of Lifespan, Providence, RI; James Padbury, Yi-Tang Tseng, Women & Infants Hosp RI, Providence, RI Y. Xu: None. H. Liu: None. C. Phornphutkul: None. D. Hardie: None. S. Dudley: None. J. Padbury: None. Y. Tseng: None. 244 Differential mRNA Expressions in Thoracic Aortic Aneurysm in Patients with Bicuspid and Tricuspid Aortic Valve Yuanjia Zhu, Andrea Hanick, Mariah Wright, John Barnard, Eric E Roselli, David R. Van Wagoner, Cleveland Clinic, Cleveland, OH Y. Zhu: None. A. Hanick: None. M. Wright: None. J. Barnard: None. E.E. Roselli: None. D.R. Van Wagoner: None. 245 Cxcl12 Chemokine Signaling Regulates Synchronous Development of Coronary Vessels and Myocardium Ching-Ling Lien, Michael R Harrison, Saban Res Inst of Childrens Hosp Los Angeles, Los Angeles, CA C. Lien: None. M.R. Harrison: None. 246 Acetylation of Vgll4 Regulates Hippo-yap Signaling and Postnatal Cardiac Growth Zhiqiang Lin, Boston Children Hosp, Boston, MA; Haidong Guo, Shanghai Univ of Traditional Chinese Med, Shanghai, China; Sylvia Zohrabian, Boston Children Hosp, Boston, MA; Yuan Cao, Inst of Molecular Med, Peking Univ, Beijing, China; William T. Pu, Boston Children Hosp, Boston, MA Z. Lin: 1. Employment; Significant; Boston Children's Hospital. 2. Research Grant; Significant; AHA SDG grant, 15SDG25590001. H. Guo: None. S. Zohrabian: 1. Employment; Significant; Boston Children' Hospital. Y. Cao: None. W. Pu: 1. Employment; Significant; Boston Children' Hospital.

This research has received full or partial funding support from the American Heart Association. 247 Rtf1 Controls Sarcomere Integrity and Cardiac Function Fei Lu, Adam Langenbacher, Chen Gao, Vincent Ren, Yibin Wang, Jau-Nian Chen, UCLA, Los Angeles, CA F. Lu: None. A. Langenbacher: None. C. Gao: None. V. Ren: None. Y. Wang: None. J. Chen: None.



AB

ST

RA

CT

S

248 Age-specific Differences in Outcomes Following Isoproterenol-induced Sudden Cardiac Death in Guinea Pigs Kathleen C Woulfe, Sarah Chau, Lori A Walker, Christine Tompkins, Carmen C Sucharov, Shelley D Miyamoto, Brian L Stauffer, Univ of Colorado, Aurora, CO K.C. Woulfe: None. S. Chau: None. L.A. Walker: None. C. Tompkins: None. C.C. Sucharov: None. S.D. Miyamoto: None. B.L. Stauffer: None. 249 The Epigenetically Modified Pro-inflammatory Cardiac Fibroblast Drives Cardiomyocyte Dysfunction in Pulmonary Hypertension-induced Right Ventricular Pressure Overload Danielle R Bruns, Stephen F Thoemmes, Peter M Buttrick, Lori A Walker, Univ of Colorado Denver, Aurora, CO D.R. Bruns: None. S.F. Thoemmes: None. P.M. Buttrick: None. L.A. Walker: None. 250 Differential Role of Autophagy in Idiopathic versus Ischemic Heart Failure in Humans Antoinette Bugyei-Twum, Krishna K. Singh, St. Michael's Hosp, Toronto, ON, Canada; Filio Billia, Univ Health Network, Toronto, ON, Canada; Kim A. Connelly, St. Michael's Hosp, Toronto, ON, Canada A. Bugyei-Twum: None. K.K. Singh: None. F. Billia: None. K.A. Connelly: None. 251 Mixed Lineage Kinase 3 Functions as a Protein Kinase G I Alpha Antiremodeling Substrate in the Heart Timothy D Calamaras, Tufts Medical Ctr, Boston, MA; Robert A Baumgartner, Univ of Pittsburgh Medical Ctr, Pittsburgh, PA; Guang-rong Wang, Tufts Medical Ctr, Boston, MA; Angela M Lane, Tulane Univ, New Orleans, LA; Mark Aronovitz, Tufts Medical Ctr, Boston, MA; Roger J Davis, Univ of Massachusetts Medical Sch, Worcester, MA; Richard H Karas, Robert M Blanton, Tufts Medical Ctr, Boston, MA T.D. Calamaras: None. R.A. Baumgartner: None. G. Wang: None. A.M. Lane: None. M. Aronovitz: None. R.J. Davis: None. R.H. Karas: None. R.M. Blanton: None.

This research has received full or partial funding support from the American Heart Association. 252 Chronic Relaxin Treatment Does Not Augment Angiotensin II Induced Aortic Pathologies in Mice Maya Dajee, Douglas G. Johns, Merck & Co, Kenilworth, NJ; Deborah A Howatt, Anju Balakrishnan, Saha Cardiovascular Res Ctr, Lexington, KY; Michael Seganish, Valdeci Da Cunha, Merck & Co, Kenilworth, NJ; Jessica J Moorleghen, Hong Lu, Saha Cardiovascular Res Ctr, Lexington, KY M. Dajee: 1. Employment; Significant; Merck. D.G. Johns: 1. Employment; Significant; Merck. D.A. Howatt: None. A. Balakrishnan: None. M. Seganish: 1. Employment; Significant; Merck. V. Da Cunha: 1. Employment; Significant; Merck. J.J. Moorleghen: None. H. Lu: None. 253 Complete Reversal of Xylazine-induced Bradycardia With Intralipid in Female Mice Negar Motayagheni, Mansoureh Eghbali, UCLA, Los Angeles, CA N. Motayagheni: None. M. Eghbali: None.

254 A Novel Mechanism for Aberrant Aldosterone Production in Heart Failure Jin Endo, Keio Univ Sch of Med, Tokyo, Japan; Kaoru Yamashita, Naohiro Yoshida, Tokyo Women's Medical Univ, Tokyo, Japan; Kentaro Ito, Keio Univ Sch of Med, Tokyo, Japan; Atsuhiro Ichihara, Tokyo Women's Medical Univ, Tokyo, Japan; Keiichi Fukuda, Motoaki Sano, Keio Univ Sch of Med, Tokyo, Japan J. Endo: None. K. Yamashita: None. N. Yoshida: None. K. Ito: None. A. Ichihara: None. K. Fukuda: None. M. Sano: None. 255 Role of Connexin 43 in Muscular Dystrophy Cardiomyopathy J. Patrick Gonzalez, Jayalakshmi Ramachandran, Chifei Kang, Lai-Hua Xie, Natalia Shirokova, Jorge Contreras, Diego Fraidenraich, Rutgers Univ, Newark, NJ J. Gonzalez: None. J. Ramachandran: None. C. Kang: None. L. Xie: None. N. Shirokova: None. J. Contreras: None. D. Fraidenraich: None. 256 Ablation of 14-3-3 Protein Exacerbates Doxorubicin Induced Cardiomyopathy: Role of Apoptosis Signal Regulating Kinase-1 Vengadeshprabhu Karuppagounder, Somasundaram Arumugam, Remya Sreedhar, Niigata Univ of Pharmacy and Applied Life Sciences, Niigata City, Japan; Vijayasree V. Giridharan, Dept of Psychiatry and Behavioral Sciences, Translational Psychiatry Program, McGovern Medical Sch, Houston, Texas, USA, Houston, TX; Rejina Afrin, Meilei Harima, Niigata Univ of Pharmacy and Applied Life Sciences, Niigata City, Japan; Kenji Suzuki, Dept of Gastroenterology, Niigata Univ Graduate Sch of Medical and Dental Sciences, Niigata City, Japan; Kazuyuki Ueno, Dept of Pharmaceutical Sciences, Niigata Univ of Pharmacy and Applied Life Sciences, Niigata City, Japan; Rajarajan A. Thandavarayan, Dept of Cardiovascular Sciences, Houston Methodist Res Inst, Houston, Texas, USA, Houston, TX; Kenichi Watanabe, Niigata Univ of Pharmacy and Applied Life Sciences, Niigata City, Japan V. Karuppagounder: None. S. Arumugam: None. R. Sreedhar: None. V.V. Giridharan: None. R. Afrin: None. M. Harima: None. K. Suzuki: None. K. Ueno: None. R.A. Thandavarayan: None. K. Watanabe: None. 257 Determining the Potential Role of cTnT Isoform Switching in the Development of Early Childhood Tropomyosin-linked DCM Melissa Lynn, Teryn Holeman, Univ of Arizona, Tucson, AZ; Lauren Tal-Grinspan, Albert Einstein Coll of Med, New York, NY; J.P. Jin, Wayne State Univ, Detroit, MI; Jil C Tardiff, Univ of Arizona, Tucson, AZ M. Lynn: None. T. Holeman: None. L. Tal-Grinspan: None. J. Jin: None. J.C. Tardiff: None.

This research has received full or partial funding support from the American Heart Association. 258 Progressive Diastolic Dysfunction, Perivascular Fibrosis and Left Ventricular Hypertrophy in LDL-Receptor Deficient Mice Walid Nachar, Univ of Montreal, Montreal, QC, Canada; Candace Lee, Montreal Heart Inst, Montreal, QC, Canada; Foued Maafi, Univ of Montreal, Montreal, QC, Canada; Yanfen Shi, Téodora Mihalache-Avram, Montreal Heart Inst, Montreal, QC, Canada; Éric Rhéaume, Jean-Claude Tardif, Univ of Montreal, Montreal, QC, Canada W. Nachar: None. C. Lee: None. F. Maafi: None. Y. Shi: None. T. Mihalache-Avram: None. É. Rhéaume: None. J. Tardif: None.


AB

ST

RA

CT

S

259 KChIP2 is a Key Transcriptional Regulator of Cardiac Excitability Under Normal and Pathogenic Conditions Drew M Nassal, Xiaoping Wan, Haiyan Liu, Danielle Maleski, Angelina Ramirez-Navarro, Heart and Vascular Res Ctr, Dept of Med, MetroHealth Campus, Case Western Reserve Univ, Cleveland, OH; Christine S Moravec, Kaufman Ctr for Heart Failure, Cleveland Clinic, Cleveland, OH; Eckhard Ficker, Kenneth R Laurita, Isabelle Deschênes, Heart and Vascular Res Ctr, Dept of Med, MetroHealth Campus, Case Western Reserve Univ, Cleveland, OH D.M. Nassal: None. X. Wan: None. H. Liu: None. D. Maleski: None. A. Ramirez-Navarro: None. C.S. Moravec: None. E. Ficker: None. K.R. Laurita: None. I. Deschênes: None.

This research has received full or partial funding support from the American Heart Association. 260 Systemic Loss of p62 Reduces Pressure Overload Induced Cardiac Hypertrophy, Dysfunction and Apoptosis Mannix Auger-Messier, Univ de Sherbrooke, Sherbrooke, QC, Canada; Khosrow Rezvani, Scott Pattison, Univ of South Dakota, Vermillion, SD M. Auger-Messier: None. K. Rezvani: None. S. Pattison: None. 261 G3bp1-Gas5 Axis Regulates Glucocorticoid Receptor Signaling During Cardiac Hypertrophy Zhi Yang, Minzhen He, Danish Sayed, Rutgers NJMS, Newark, NJ Z. Yang: None. M. He: None. D. Sayed: None.

This research has received full or partial funding support from the American Heart Association. 262 A Rat Model of Heart Failure with Preserved Ejection Fraction Induced by Pressure Overload Shu-Yu Sun, Barry Campbell, Valdeci Da Cunha, Xuening Hong, Chin-hu Huang, Richard Kennan, Xiaoli Ping, Xiaolan Shen, Kersten Small, Liming Yang, Huawei Zhao, Shuqin Zheng, Jeffrey B Madwed, Merck & Co., Inc., Kenilworth, NJ S. Sun: 1. Employment; Significant; employee. B. Campbell: 1. Employment; Significant; employee. V. Da Cunha: 1. Employment; Significant; employee. X. Hong: 1. Employment; Significant; employee. C. Huang: 1. Employment; Significant; employee. R. Kennan: 1. Employment; Significant; employee. X. Ping: 1. Employment; Significant; employee. X. Shen: 1. Employment; Significant; employee. K. Small: 1. Employment; Significant; employee. L. Yang: 1. Employment; Significant; employee. H. Zhao: 1. Employment; Significant; employee. S. Zheng: 1. Employment; Significant; employee. J.B. Madwed: 1. Employment; Significant; employee. 263 A Decline in Kidney-derived Protein Klotho Contributes to Aging-related Heart Failure Zhongjie Sun, Kai Chen, Univ Oklahoma Health Sciences Ctr, Oklahoma City, OK Z. Sun: None. K. Chen: None.

264 Inhibiting Fibronectin Improves Cardiac Function in a Mouse Model of Heart Failure Iñigo Valiente-Alandi, Cincinnati Children's Hosp Medical Ctr, Cincinnati, OH; Michelle Nieman, Univ of Cincinnati, Cincinnati, OH; Burns C. Blaxall, Cincinnati Children's Hosp Medical Ctr, Cincinnati, OH I. Valiente-Alandi: None. M. Nieman: None. B. Blaxall: None. 265 Identification of MicroRNA in an Ovine Model of Heart Failure Lee Lee Wong, Eng Leng Saw, Kar Sheng Lew, Cardiovascular Res Inst, Natl Univ of Singapore, Singapore, Singapore; Miriam T Rademaker, Leigh J Ellmers, Christopher J Charles, Christchurch Heart Inst, Dept of Med, Univ of Otago, Christchurch, New Zealand; Arthur Mark Richards, Peipei Wang, Cardiovascular Res Inst, Natl Univ of Singapore, Singapore, Singapore L. Wong: None. E. Saw: None. K. Lew: None. M.T. Rademaker: None. L.J. Ellmers: None. C.J. Charles: None. A.M. Richards: None. P. Wang: None. 266 Is the Col4a3-/- Alport Mouse a Novel Model for Heart Failure With Preserved Ejection Fraction? Keyvan Yousefi, Wen Ding, Jayanti Singh, Lina Shehadeh, Univ of Miami Sch of Med, Miami, FL K. Yousefi: None. W. Ding: None. J. Singh: None. L. Shehadeh: None.

This research has received full or partial funding support from the American Heart Association. 267 Activation of a Novel Estrogen Receptor Ameliorates Experimental Pulmonary Hypertension in Male Rats Gisele Zapata-Sudo, Allan Kardec Alencar, Guilherme Carneiro Montes, Sabrina Teixeira Martinez, Aline Guerra Fraga, Univ Federal Do Rio De Janeiro, Rio Janeiro, Brazil; Hao Wang, Leanne Groban, Wake Forest Univ, Winston Salem, NC; Roberto Takashi Sudo, Univ Federal Do Rio De Janeiro, Rio Janeiro, Brazil G. Zapata-Sudo: 2. Research Grant; Significant; CAPES, CNPq, INCT-INOFAR, PRONEX, FAPERJ. A.K.N. Alencar: 2. Research Grant; Modest; CAPES, FAPERJ, CNPq. G.C. Montes: 2. Research Grant; Modest; CAPES, FAPERJ, CNPq. S.T. Martinez: None. A.G. Fraga: None. H. Wang: None. L. Groban: None. R.T. Sudo: 2. Research Grant; Significant; CAPES, CNPq, INCT-INOFAR, PRONEX, FAPERJ. 268 Advanced Glycation End Products Effect on the Polarization of Macrophages Cardiac After Acute Myocardial Infarction in Wistar Rats Juliana O Rangel, Bianca Fracasso, Amanda Phaelante, Fernanda Curuja, Daniel Sturza, UFRGS- Univ Federal do Rio Grande do Sul, Porto Alegre, Brazil; Nadine Clausell, Andreia Biolo, Luis E Rohde, Michael Andrades, Hosp de Clínicas de Porto Alegre, Porto Alegre, Brazil J.O. Rangel: None. B. Fracasso: None. A. Phaelante: None. F. Curuja: None. D. Sturza: None. N. Clausell: None. A. Biolo: None. L.E.P. Rohde: None. M. Andrades: None.


AB

ST

RA

CT

S

269 Miofibroblast Tgf-beta Signaling in a Proteotoxic Mouse Model Bidur Bhandary, Qinghang Meng, Hanna Osinska, Kritton Shay-Winkler, James Gulick, CCHMC, Cincinnati, OH; Shenuarin Bhuiyan Md., Louisiana State Univ, Sherveport, LA; Jeffrey Robbins, CCHMC, Cincinnati, OH B. Bhandary: None. Q. Meng: None. H. Osinska: None. K. Shay-Winkler: None. J. Gulick: None. S. Bhuiyan Md.: None. J. Robbins: None. 270 mTORC1 is Essential for Cardiomyocyte Homeostasis and Female Sex Related Cardioprotection Dennis B Guergen, Nelli Beiner, Rusan Catar, Charité Univsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany; Thorsten Mielke, Max-Planck-Inst für molekulare Genetik, Berlin, Germany; Hauke Busch, Inst für Molekulare Med und Zellforschung, Univ Freiburg, Freiburg im Breisgau, Germany, Freiburg, Germany; Melanie Boerries, Inst für Molekulare Med und Zellforschung, Univ Freiburg, Freiburg im Breisgau, Germany; Joern Dengjel, Ctr for Biological Systems Analysis, Univ Freiburg, Freiburg, Germany; Marijke Brink, Dept of Biomedicine, Univ Hosp Basel, Basel, Switzerland; Florian Grahammer, Klinik für Innere Med IV, Univsklinikum Freiburg, Freiburg, Germany, Freiburg, Germany; Tobias B Huber, Klinik für Innere Med IV, Univsklinikum Freiburg, Freiburg, Germany; Angelika Kusch, Duska Dragun, Charité Univsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany D.B. Guergen: None. N. Beiner: None. R. Catar: None. T. Mielke: None. H. Busch: None. M. Boerries: None. J. Dengjel: None. M. Brink: None. F. Grahammer: None. T.B. Huber: None. A. Kusch: None. D. Dragun: None. 271 NF-kB Mediated Modulation of mir-23b/-130a-axis is Critical for Cardiac Remodeling Sudhiranjan Gupta, Li Li, Cardiovascular Res Inst, Temple, TX S. Gupta: 2. Research Grant; Modest; GIA-AHA, 4GRNT20490320. L. Li: None.

This research has received full or partial funding support from the American Heart Association. 272 miRNA-7 Leads to Enhanced Fibrosis in the Heart Manveen Gupta, Xi Wang, Elizabeth Martelli, Prasad Sathyamangla, Cleveland Clinic, Cleveland, OH M. Gupta: None. X. Wang: None. E. Martelli: None. P. Sathyamangla: None.

This research has received full or partial funding support from the American Heart Association. 273 T cell Sphingosine 1-Phosphate Receptor 1 Signaling Possesses Intrinsic Anti-fibrotic Effects in Murine Heart Zhuqiu Jin, California Northstate Univ, Elk Grove, CA; Chowdhury S Abdullah, South Dakota State Univ, Brookings, SD Z. Jin: None. C.S. Abdullah: None. 274 Expression and Phosphorylation States of Eukaryotic Elongation Factor 2 (EEF2) and EEF2 Kinase in Cardiomyocytes From Hypertrophy Models Satoshi Kameshima, Muneyoshi Okada, Shiro Ikeda, Yuki Watanabe, Hideyuki Yamawaki, Kitasato Univ, Towada City, Japan S. Kameshima: None. M. Okada: None. S. Ikeda: None. Y. Watanabe: None. H. Yamawaki: None.

275 The Role of Fibroblast-specific Canonical TGFβ Signaling in Cardiac Fibrosis Hadi Khalil, Cincinnati Childrens Hosp Medical Ctr, Cincinnati, OH H. Khalil: None. 276 Stretch Enhances Beta-2 Microglobulin Secretion from Cardiomyocytes <and> Promotes Cardiac Fibroblasts Activation Yang Li, Xiaoyi Zhang, Zhidan Chen, Yong Ye, Chunjie Yang, Guoping Zhang, Jianguo Jia, Hui Gong, Yunzeng Zou, Fudan Univ, Shanghai, China Y. Li: None. X. Zhang: None. Z. Chen: None. Y. Ye: None. C. Yang: None. G. Zhang: None. J. Jia: None. H. Gong: None. Y. Zou: None. 277 Microrna-33 Promotes Cardiac Fibrosis by Maintaining Cellular Lipid Homeostasis Masataka Nishiga, Takahiro Horie, Yasuhide Kuwabara, Osamu Baba, Tetsushi Nakao, Tomohiro Nishino, Daihiko Hakuno, Yasuhiro Nakashima, Noriko Nakazeki, Yuya Ide, Satoshi Koyama, Dept of Cardiovascular Med, Graduate Sch of Med, Kyoto Univ, Kyoto, Japan; Koji Hasegawa, Div of Translational Res, Natl Hosp Organization, Kyoto Medical Ctr, Kyoto, Japan; Toru Kita, Kobe City Medical Ctr General Hosp, Kobe, Japan; Takeshi Kimura, Koh Ono, Dept of Cardiovascular Med, Graduate Sch of Med, Kyoto Univ, Kyoto, Japan M. Nishiga: None. T. Horie: None. Y. Kuwabara: None. O. Baba: None. T. Nakao: None. T. Nishino: None. D. Hakuno: None. Y. Nakashima: None. N. Nakazeki: None. Y. Ide: None. S. Koyama: None. K. Hasegawa: None. T. Kita: None. T. Kimura: None. K. Ono: None. 278 Domain-specific Roles for GRK2 in Cardiac Hypertrophy and Heart Failure Sarah M Schumacher, Erhe Gao, J. Kurt Chuprun, Walter J. Koch, Temple Univ Sch of Med, Philadelphia, PA S.M. Schumacher: None. E. Gao: None. J. Chuprun: None. W. Koch: None. 279 Stromal Cell-derived Factor-1 Prevents from Diabetic Cardiomyopathy via Cxcr7/ampk-mediated Nrf2 Activation in Type 2 Diabetic Mice Shudong Wang, Jilin Univ, Changchun, China; Junlian Gu, Univ of Louisville, Louisville, KY; Xiaoqing Yan, Wenzhou Medical Univ, Wenzhou, China; Jing Chen, Jun Chen, Lu Cai, Univ of Louisville, Louisville, KY; Quan Liu, Yang Zheng, Jilin Univ, Changchun, China; Yi Tan, Univ of Louisville, Louisville, KY S. Wang: None. J. Gu: None. X. Yan: None. J. Chen: None. J. Chen: None. L. Cai: None. Q. Liu: None. Y. Zheng: None. Y. Tan: None. 280 Cardiac Fibroblast Specific Deletion of Gsk3α Alleviate From Cardiac Dysfunction and Fibrotic Remodeling in Ischemic Heart Vipin K Verma, Firdos Ahmad, Qinkun Zhang, Thomas L. Force, Hind Lal, Vanderbilt Univ, Nashville, TN V.K. Verma: None. F. Ahmad: None. Q. Zhang: None. T.L. Force: None. H. Lal: None.


AB

ST

RA

CT

S

281 Sigma-1 Receptor Dependent Pathway for a Protective Endoplasmic Reticulum Stress Response in Cardiomyocytes Shafiul Alam, A. Wayne Orr, Christopher B. Pattillo, Md. Shenuarin Bhuiyan, LSU Health Sciences Ctr-Shreveport, Shreveport, LA S. Alam: None. A. Orr: None. C. Pattillo: None. M. Bhuiyan: None. 282 Adropin Enhancement of Cardiac Insulin Sensitivity and Inhibition of Fatty Acid Oxidation are Associated with Improvement of Cardiac Function and Efficiency in Hearts From Fasted Mice Tariq R Altamimi, Arata Fukushima, Liyan Zhang, Su Gao, Abhishek Gupta, Gary D Lopaschuk, Univ of Alberta, Edmonton, AB, Canada T.R. Altamimi: None. A. Fukushima: None. L. Zhang: None. S. Gao: None. A. Gupta: None. G.D. Lopaschuk: None. 283 SGK1-Dependent Sirt3 Phosphorylation Regulates Mitochondrial Dynamics Dallas Ellis III, Takara Scott, Wei Zhong, Oguljahan Babayeva, Sharon C Francis, Morehouse Sch of Med, Atlanta, GA D. Ellis: None. T. Scott: None. W. Zhong: None. O. Babayeva: None. S.C. Francis: None. 284 Ovariectomy Exacerbates Mitochondrial Dysfunction, Oxidative Stress and Fibrosis to Cause Diastolic Dysfunction Dale J. Hamilton, Shumin Li, Aijun Zhang, Indira Vedula, Jessie A. Smith, Anisha A Gupte, Houston Methodist Res Inst, Houston, TX D.J. Hamilton: None. S. Li: None. A. Zhang: None. I. Vedula: None. J.A. Smith: None. A.A. Gupte: None.

This research has received full or partial funding support from the American Heart Association. 285 Endoplasmic Reticulum Stress Induces Mitochondrial ROS Overproduction and Contributes to Electrical Remodeling in Heart Failure Man Liu, Guangbin Shi, Dmitry Terentyev, Anyu Zhou, Samuel C. Dudley Jr., Lifespan Cardiovascular Inst, the Providence VA Medical Ctr, and Brown Univ, Providence, RI M. Liu: None. G. Shi: None. D. Terentyev: None. A. Zhou: None. S.C. Dudley: None. 286 Role of ATP-sensitive Potassium Channel Openers in Prevention of Atrial Fibrillation Cevher Ozcan, Zhenping Li, Univ of Chicago, Chicago, IL C. Ozcan: None. Z. Li: None. 287 Obesity Accelerates T Cell Senescence Kohsuke Shirakawa, Tsunehisa Yamamoto, Jin Enso, Keiichi Fukuda, Motoaki Sano, Keio Univ, Tokyo, Japan K. Shirakawa: None. T. Yamamoto: None. J. Enso: None. K. Fukuda: None. M. Sano: None. 288 Novel Mechanisms of Non-coding Genomic Regulation Identified in Cardiac Disease-in-a-dish Models Aditya Kumar, Stephanie Thomas, Kirsten Wong, Kevin Tenerelli, Univ of California, San Diego, San Diego, CA; Valentina Lo Sardo, William Ferguson, Eric Topol, Kristin Baldwin, The Scripps Res Inst, San Diego, CA; Adam Engler, Univ of California, San Diego, San Diego, CA

A. Kumar: None. S. Thomas: None. K. Wong: None. K. Tenerelli: None. V. Lo Sardo: None. W. Ferguson: None. E. Topol: None. K. Baldwin: None. A. Engler: None. 289 Transcriptomic Analysis of Inter- and Intra-patient Variation in Human iPSCs: Platform for Precision Medicine to Predict Drug Toxicity Elena Matsa, Paul W Burridge, Kun-Hsing Yu, Haodi Wu, Vittavat Termglinchan, Chun Liu, Praveen Shukla, Nazish Sayed, Ioannis Karakikes, Michael P Snyder, Joseph C Wu, Stanford Univ Sch of Med, Stanford, CA E. Matsa: None. P.W. Burridge: None. K. Yu: None. H. Wu: None. V. Termglinchan: None. C. Liu: None. P. Shukla: None. N. Sayed: None. I. Karakikes: None. M.P. Snyder: None. J.C. Wu: None.

This research has received full or partial funding support from the American Heart Association. 290 Metoprolol Induces Cardiac Beta3-adrenergic Receptor and Sphingosine-1 Phosphate Receptor 1 Signaling to Prevent Adverse Cardiac Remodeling and Dysfunction After Myocardial Infarction Alessandro Cannavo, Daniela Liccardo, Temple Univ, Philadelphia, PA; Andres Pun, Ctr Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Giuseppina Gambino, Maria Loreta D'Amico, Federico II Univ of Naples, Naples, Italy; Nazareno Paolocci, Johns Hopkins Univ Medical Insts, Baltimore, MD; Borja Ibanez, Ctr Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Giuseppe Rengo, Federico II Univ of Naples, Naples, Italy; Walter J Koch, Temple Univ, Philadelphia, PA A. Cannavo: None. D. Liccardo: None. A. Pun: None. G. Gambino: None. M. D'Amico: None. N. Paolocci: None. B. Ibanez: None. G. Rengo: None. W.J. Koch: None. 291 MANF, a Structurally Unique ER Stress-inducible Protein, Restores ER-protein Folding in ER Stressed Cardiac Myocytes and in the Ischemic Heart Adrian Arrieta, Winston T. Stauffer, Amber N. Pentoney, Erik A. Blackwood, San Diego State Univ, San Diego, CA; Shirin Doroudgar, Univ of Heidelberg, Heidelberg, Germany; Christopher C. Glembotski, San Diego State Univ, San Diego, CA A. Arrieta: None. W.T. Stauffer: None. A.N. Pentoney: None. E.A. Blackwood: None. S. Doroudgar: None. C.C. Glembotski: None. 292 The Role of the ATF6 Branch of the ER Stress Response in the Endocrine Heart Erik A Blackwood, Christopher C Glembotski, San Diego State Univ Heart Inst, San Diego, CA E.A. Blackwood: None. C.C. Glembotski: None. 293 MicroRNA-125b-5p Protect the Mouse Heart From Ischemic Injury by Repressing Pro-apoptotic Bak1 And Klf13 in Cardiomyocytes Zuzana Broskova, Kyoung-mi Park, Yongchao Wang, Il-man Kim, Augusta Univ, Augusta, GA Z. Broskova: None. K. Park: None. Y. Wang: None. I. Kim: None.



AB

ST

RA

CT

S

294 Therapeutic Silencing of miR-375 Attenuates Post-MI Inflammatory Response and Left Ventricular Dysfunction in Mice With Myocardial Infarction Venkata N Garikipati, Suresh K Verma, Temple Univ, Philadelphia, PA; Darukeshwara Jolardarashi, Houston Methodist Res Inst, Houston, TX; Maria Cimini, Jessica Ibetti, Yujia Yue, Cindy Benedict, Emily Nickoloff, Ehre Gao, Temple Univ, Philadelphia, PA; Prasannna Krishnamurthy, Houston Methodist Res Inst, Houston, TX; Walter J Koch, Raj Kishore, Temple Univ, Philadelphia, PA V.N.S. Garikipati: None. S.K. Verma: None. D. Jolardarashi: None. M. Cimini: None. J. Ibetti: None. Y. Yue: None. C. Benedict: None. E. Nickoloff: None. E. Gao: None. P. Krishnamurthy: None. W.J. Koch: None. R. Kishore: None.

This research has received full or partial funding support from the American Heart Association. 295 Importance of the Rate of Platelet Activation by Thrombin for Regulating the Size of Thrombi Formed Under Low Blood Flow Velocity Conditions Shinichi Goto, Kengo Ayabe, Youth Kawamura, Noriko Tamura, Shinya Goto, Tokai Univ, Kanagawa, Japan S. Goto: None. K. Ayabe: None. Y. Kawamura: None. N. Tamura: None. S. Goto: 2. Research Grant; Modest; Pfizer, BMS. 2. Research Grant; Significant; Sanofi. 4. Speakers’ Bureau; Modest; Pfeizer. 5. Honoraria; Modest; Eisai, Otsuka, Bayer, Novartis, Asteras, Pfizer, Medtronics-Japan, Tanabe-Mitsubishi, Tacked, Daiichi-Sankyo, Mochica, MSD. 5. Honoraria; Significant; Sanofi, AstraZeneca. 8. Consultant/Advisory Board; Modest; BMS, Armethron, Bayer. 296 Loss of Trpc6 Function in Cardiomyocytes Improves Survival and Attenuates Progression of Cardiac Dysfunction After Mi Polina Gross, Lewis Katz Temple Univ Sch of Med, Philadelphia, PA; Xiaoxiao Zhang, Tao Wang, Amir Toib, Markus Wallner, Timothy Starosta, Daohai Yu, Xiongwen Chen, Steven Houser, Temple Univ, Philadelphia, PA P. Gross: None. X. Zhang: None. T. Wang: None. A. Toib: None. M. Wallner: None. T. Starosta: None. D. Yu: None. X. Chen: None. S. Houser: None. 297 The Oracle™ Device: A New Snare for Removal of Thrombus Richard R Heuser, St. Luke's Hosp and Medical Ctr, Phoenix, AZ R.R. Heuser: 9. Other; Modest; Owner of the Oracle device. 298 Pluripotent Stem Cell Microrna-294 as a Mediator of Cardiac Proliferative Response After Myocardial Injury Mohsin Khan 19140, Brandon Booth, Constantine D Troupes, Sadia Mohsin, Emily Nickoloff, Cynthia Benedict, Steven R Houser, Walter J Koch, Raj Kishore, Temple Univ, Philadelphia, PA M. Khan: None. B. Booth: None. C.D. Troupes: None. S. Mohsin: None. E. Nickoloff: None. C. Benedict: None. S.R. Houser: None. W.J. Koch: None. R. Kishore: None.


299 Natural Product Derivative Bio Promotes Recovery After Myocardial Infarction via Unique Modulation of the Cardiac Microenvironment Yong Sook Kim, Wan Seok Kang, Ju Hee Kang, Youngkeun Ahn, Chonnam Nat Univ Hosp, Gwangju, Korea, Republic of Y. Kim: None. W. Kang: None. J. Kang: None. Y. Ahn: None. 300 Alda-1 Attenuates Acute Ischemia-reperfusion Mediated Cardiac Damage in Aldehyde Dehydrogenase 2 Mutant Diabetic Mice Guodong Pan, Henry Ford Health System, Detroit, MI G. Pan: None. 301 Initial Increase of Klf5 and Ppara Expression after Myocardial Ischemia/Reperfusion in Mice Appears to be Critical for Survival Christine J Pol, Mesele-Christina Valenti, Sarah M Schumacher, Ancai Yuan, Erhe Gao, Temple Univ, Philadelphia, PA; Ira J Goldberg, NYU-Langone Sch of Med, New York, NY; Walter J Koch, Konstantinos Drosatos, Temple Univ, Philadelphia, PA C.J. Pol: None. M. Valenti: None. S.M. Schumacher: None. A. Yuan: None. E. Gao: None. I.J. Goldberg: None. W.J. Koch: None. K. Drosatos: None. 302 Cathepsin D Haploinsufficiency Exacerbates Post Myocardial Infarction Cardiac Remodeling and Malfunction by Impairing Autophagosome Removal Penglong Wu, Div of Basic Biomedical Sciences, Sanford Sch of Med of the Univ of South Dakota, Vermillion, SD; Wei Zhu, Clinical Res Ctr, The Second Affiliated Hosp of Zhejiang Univ Sch of Med, Hangzhou, Zhejiang, China; Jingbo Li, Dept of Cardiology, Shanghai Jiao Tong Univ affiliated Sixth People’s Hosp, Shanghai, China; Xuejun “XJ” Wang, Div of Basic Biomedical Sciences, Sanford Sch of Med of the Univ of South Dakota, Vermillion, SD P. Wu: None. W. Zhu: None. J. Li: None. X. Wang: None. 303 Optical Tissue Interrogation Technology Incorporated in Irrigated Radiofrequency Ablation Provides Real Time Monitoring of Ablation Lesion Depth Talal Alzahrani, Dept of Internal Med, George Washington Univ, Washington, DC; Mohammed Aljishi, Dept of Pharmacology and Physiology, George Washington Univ, Washington, DC; Marco Mercader, Div of Cardiology, George Washington Univ, Washington, DC T. Alzahrani: None. M. Aljishi: None. M. Mercader: None. 304 Selective Targeting of a Novel Epsin-VEGFR2 Interaction Promotes VEGF-mediated Angiogenesis Hong Chen, Harvard Medical Sch, Boston, MA H. Chen: None.

This research has received full or partial funding support from the American Heart Association. 305 Carvacrol Attenuates Diabetic Cardiomyopathy by Enhancing PI3K/AKT Pathway in STZ-induced Type 1 Diabetic C57BL/6J Mice Ning Hou, Yunpei Mai, Wenliang Chen, Coll of Pharmacy, Guangzhou, China; Faqian Li, Dept of Lab Med and Pathology, Minneapolis, MN; Jiandong Luo, Coll of Pharmacy, Guangzhou, China N. Hou: None. Y. Mai: None. W. Chen: None. F. Li: None. J. Luo: None.


AB

ST

RA

CT

S

306 Targeting of Cdc42-Interacting Protein 4 - Calcineurin Aβ Complexes Ameliorates Pressure Overload-induced Cardiac Remodeling Xiaofeng Li, Interdisciplinary Stem Cell Inst Univ of Miami Miller Sch of Med, Miami, FL; Jinliang Li, Eliana C Martinez Valencia, Interdisciplinary Stem Cell Inst, Dept of Pediatrics, Miami, FL; Catherine Passariello, Hrishikesh Thakur, Interdisciplinary Stem Cell Inst Univ of Miami Miller Sch of Med, Miami, FL; Michael S. Kapiloff, Interdisciplinary Stem Cell Inst, Dept of Pediatrics, Miami, FL X. Li: None. J. Li: 7. Ownership Interest; Significant; Dr. Li is a co-inventor of intellectual property used in the study and may gain royalties from its future commercialization. E.C. Valencia: None. C. Passariello: None. H. Thakur: None. M.S. Kapiloff: 7. Ownership Interest; Significant; Dr. Kapiloff is a co-inventor of intellectual property used in the study and may gain royalties from its future commercialization. 9. Other; Significant; Dr. Kapiloff is an equity owner and on the Board of Directors of Cardiac RSK3 Inhibitors, LLC.

This research has received full or partial funding support from the American Heart Association. 307 Apoa-1 Binding Protein Regulates Retinal Angiogenesis via Control of Notch Signaling Renfang Mao, Houston Methodist Res Inst, Ctr for Cardiovascular Regeneration, Dept of Cardiovascular Science, Housotn, TX; Yury Miller, Univ of California, Dept of Med, San Diego, CA; Longhou Fang, Houston Methodist Res Inst, Housotn, TX R. Mao: None. Y. Miller: None. L. Fang: None. 308 Differential Regulation of Alpha1a-adrenergic Receptor and its Genetic Variant Signaling by Novel Spinophilin-RGS2 Signalosome in Human Cells Ekaterina Babaeva, Irina Gradinaru, Univ of Washington, Seatlle, WA; Debra A Schwinn, Univ of Iowa, Iowa, IA; Anush Oganesian, Univ of Washington, Seatlle, WA E. Babaeva: None. I. Gradinaru: None. D.A. Schwinn: None. A. Oganesian: None. 309 Deletion of a Specific Type-I Transforming Growth Factor-beta Receptor Attenuates Thoracic Aortic Aneurysm Development Robert E. Stroud, Sarah L. Lieser, Adam N. Franklin, Elizabeth K. Nadeau, Rupak Mukherjee, John S. Ikonomidis, Jeffrey A. Jones, Medical Univ of South Carolina, Charleston, SC R.E. Stroud: 2. Research Grant; Significant; R01 AG036954, R01 HL102121, IO1 BX000904, I21 RX001707. S.L. Lieser: None. A.N. Franklin: None. E.K. Nadeau: None. R. Mukherjee: 2. Research Grant; Significant; R01 AG036954, R01 HL102121, IO1 BX000904, I21 RX001707. J.S. Ikonomidis: 2. Research Grant; Significant; R01 AG036954, R01 HL102121, IO1 BX000904, I21 RX001707. J.A. Jones: 2. Research Grant; Significant; R01 AG036954, R01 HL102121, IO1 BX000904, I21 RX001707. 310 Beta-adrenergic Receptor/beta-arrestin-mediated MicroRNA Maturation Confers Cardiac Cell Survival Jian-peng Teoh, Il-man Kim, Augusta Univ, Augusta, GA J. Teoh: None. I. Kim: 2. Research Grant; Significant; 14SDG18970040, R01 HL124251.

311 Opposing Roles TCF7/LEF1 and TCF7L2 in Wnt/β-Catenin and BMP Signaling During Late Heart Development Bo Ye, Univ of Minnesota, Minneapolis, MN; Haodong Xu, Dept of Pathology and Lab, David Geffen Sch of Med at UCLA, Los Angeles, CA; Faqian Li, Univ of Minnesota, Minneapolis, MN B. Ye: None. H. Xu: None. F. Li: None.

This research has received full or partial funding support from the American Heart Association. 312 Arterial CEPT1 Expression Correlates with Diabetes and Atherosclerotic Occlusive Disease Mohamed A Zayed, Uzma Naim, Kyoung-mi Park, Larisa Belaygorod, Washington Univ Sch of Med, Section of Vascular Surgery, St. Louis, MO; Clay Semenkovich, Washington Univ Sch of Med, Div of Endocrinology, Metabolism, and Lipid Res, St. Louis, MO M.A. Zayed: None. U. Naim: None. K. Park: None. L. Belaygorod: None. C. Semenkovich: None. 313 Nonionic Acid is a Target Metabolite of Diabetic Microvasculopathy Yasuko K. Bando, Haruya Kawase, Kazuyuki Nishimura, Akio Monji, Toyoaki Murohara, Nagoya Univ., Nagoya Aichi, Japan Y.K. Bando: 2. Research Grant; Modest; MSD AstraZeneca, Takeda, Tanabe. 4. Speakers’ Bureau; Modest; MSD, Takeda, AstraZeneca, Tanabe. H. Kawase: None. K. Nishimura: None. A. Monji: None. T. Murohara: None. 314 Sensory Innervation of the Papillary Muscle: A Neural Link Between Mitral Valve Prolapse and Malignant Ventricular Arrhythmias? Krishan J. Patel, Olujimi A. Ajijola, Michael Fishbein, Kalyanam Shivkumar, Univ of California, Los Angeles, Los Angeles, CA K.J. Patel: None. O.A. Ajijola: None. M. Fishbein: None. K. Shivkumar: None. 315 Efficacy and Safety of Rivaroxaban in in vitro Experiments With the Endothelial Cells Kaname Seki, Yosuke Mizuno, Toku Sakashita, Jun Tanno, Shintaro Nakano, Toshihiro Muramatsu, Shigeyuki Nishimura, Takaaki Senbonmatsu, Saitama Medical Univ, Hidaka City, Saitama, Japan K. Seki: None. Y. Mizuno: None. T. Sakashita: None. J. Tanno: None. S. Nakano: None. T. Muramatsu: None. S. Nishimura: None. T. Senbonmatsu: None. 316 Engineering Nanomaterial Morphology for Targeting Immune Cells Within Atherosclerotic Lesions Sijia Yi, Chemistry of Life Processes Inst, Evanston, IL; Yugang Liu, Sean Allen, Fanfan Du, Xiaomo Li, Brian Ouyang, Evan Scott, Northwestern, Evanston, IL S. Yi: None. Y. Liu: None. S. Allen: None. F. Du: None. X. Li: None. B. Ouyang: None. E. Scott: None.



AB

ST

RA

CT

S

317 Med12 is a Transcriptional Mediator of Cardiac Contractile Function Kedryn K. Baskin, Catherine A. Makarewich, Susan DeLeon, Rhonda Bassel-Duby, Eric N. Olson, UT Southwestern Medical Ctr, Dallas, TX K.K. Baskin: None. C.A. Makarewich: None. S. DeLeon: None. R. Bassel-Duby: None. E.N. Olson: None. 318 Vitamin E Affects Pathological Cardiac Hypertrophy and MicroRNAs Expression in Mice Carolina R Cohen, Nidiane C Martinelli, Graziela H Pinto, Amanda Phaelante, Daiane Silvello, Mariana Recamonde-Mendoza, Michael E Andrades, Nadine Clausell, Luis E Rohde, Patrícia Ashton-Prolla, Andréia Biolo, Federal Univ of Rio Grande do Sul, Porto Alegre, Brazil C.R. Cohen: None. N.C. Martinelli: None. G.H. Pinto: None. A. Phaelante: None. D. Silvello: None. M. Recamonde-Mendoza: None. M.E. Andrades: None. N. Clausell: None. L.E. Rohde: None. P. Ashton-Prolla: None. A. Biolo: None. 319 Structural Reorganization of Cardiac Transcription Factories Mediates Transcriptional Changes in Response to Stress Elaheh Karbassi, Manuel Rosa Garrido, Douglas J Chapski, Yong Wu, Emma Monte, Thomas M Vondriska, UCLA, Los Angeles, CA E. Karbassi: None. M. Rosa Garrido: None. D.J. Chapski: None. Y. Wu: None. E. Monte: None. T.M. Vondriska: None.

This research has received full or partial funding support from the American Heart Association. 320 Identification of Temporally Modulated Lncrnas in Cardiac Hypertrophy and Failure Marcello Rubino Sr., Giuliano Stirparo 20089, Pier Luigi Rossi, Carolina Greco, Paolo Kunderfranco, Pierluigi Carullo, Simone Serio, Roberto Papait, Gianluigi Condorelli, Humanitas Clinical and Res Ctr, Rozzano, Italy M. Rubino: None. G. Stirparo: None. P. Rossi: None. C. Greco: None. P. Kunderfranco: None. P. Carullo: None. S. Serio: None. R. Papait: None. G. Condorelli: None. 321 miR-125b-3p Cox20 Axis Deregulation in the Novel Combined Model of Pulmonary Fibrosis, Pulmonary Hypertension Gregoire Ruffenach, Soban Umar, Mansoureh Eghbali, UCLA Sch of Medecin, Los Angeles, CA G. Ruffenach: None. S. Umar: None. M. Eghbali: None. 350 Chromosome Content of Cardiac Progenitor Cells Influence on Regenerative Potential in the Heart Kathleen Broughton, Tiffany Khieu, Nicky Nguyen, San Diego State Univ, San Diego, CA; Sadia Mohsin, Temple Univ, Philadelphia, PA; Pearl Quijada, Jessica Wang, Megan Monsanto, Natalie Gude, Mark Sussman, San Diego State Univ, San Diego, CA K. Broughton: None. T. Khieu: None. N. Nguyen: None. S. Mohsin: None. P. Quijada: None. J. Wang: None. M. Monsanto: None. N. Gude: None. M. Sussman: None.

351 Allogeneic C-kit+ Cardiac Progenitor Cells are Immune Tolerant with Strong Efficacy for Cardiac Functional Recovery Srinivasa Raju Datla, Yin Guo, Rachana Mishra, Ling Chen, Progyaparamita Saha, Sudhish Sharma, Grace Bigham, Godly Jack, Sunjay Kaushal, Univ of Maryland, Baltimore, MD S. Datla: None. Y. Guo: None. R. Mishra: None. L. Chen: None. P. Saha: None. S. Sharma: None. G. Bigham: None. G. Jack: None. S. Kaushal: None. 352 The Effect of the Extracellular Matrix of Failing Hearts on Cardiac Stem Cells Dawn A Delfín, Joshua DeAguero, Elizabeth N McKown, Univ of New Mexico, Albuquerque, NM D.A. Delfín: None. J. DeAguero: None. E.N. McKown: None.

This research has received full or partial funding support from the American Heart Association. 353 P2Y2 Nucleotide Receptor Overexpression: Letting Blind Cardiac Progenitor Cells ‘See’ Again Farid Khalafalla, Steven Greene, Jonathan Nguyen, Kelli Ilves, Benjamin Norman, Roberto Jr Alvarez, Mark Sussman, San Diego State Univ, San Diego, CA F. Khalafalla: None. S. Greene: None. J. Nguyen: None. K. Ilves: None. B. Norman: None. R.J. Alvarez: None. M. Sussman: 9. Other; Significant; CardioCreate Company. 354 Optimization of Extracellular Vesicles Isolation from Cardiac Mesenchymal Cells Talha A Farid, Asif R Pathan, Abdur R Khan, Marjan Nasr, Hong Li, Senthilkumar Muthusamy, Marcin Wysoczynski, Roberto Bolli, Univ of Louisville, Louisville, KY T.A. Farid: None. A.R. Pathan: None. A.R. Khan: None. M. Nasr: None. H. Li: None. S. Muthusamy: None. M. Wysoczynski: None. R. Bolli: None. 355 Heart Failure Impairs Bone Marrow Mesenchymal Stem Cell Renewing Capacity and Migration Victoria Florea, Univ of Miami, Miami, FL; Cristina Sanina, Montefiore Hosp, New York, NY; Darcy Difede, Krystalenia Valasaki, Aisha Khan, Joshua Hare, Univ of Miami, Miami, FL V. Florea: None. C. Sanina: None. D. Difede: None. K. Valasaki: None. A. Khan: None. J. Hare: 2. Research Grant; Modest; RO1HL084275, RO1HL107110, RO1HL110737, UM1HL113460. 3. Other Research Support; Modest; Grants from the Starr Foundation and the Soffer Family Foundation. 8. Consultant/Advisory Board; Modest; Dr. Hare holds equity in Vestion Inc.; and maintains a professional relationship with Vestion as a consultant and member of the Board of Directors and Scientific Advisory Board. 356 Sam68 Promotes NF-kB Signaling and Inflammation in Macrophages and Impedes the Recovery of Arterial Injury Shuling Han, Junlan Zhou, Gangjian Qin, Feinberg Cardiovascular Res Inst, Chicago, IL S. Han: None. J. Zhou: None. G. Qin: None.



AB

ST

RA

CT

S

357 Role of Combinatorial Extracellular Matrix Proteins in Modulating Endothelial Differentiation of Human Induced Pluripotent Stem Cells Luqia Hou, Joseph Kim, Stanford Univ, Stanford, CA; John Coller, Vanita Natu, Stanford Functional Genomics Facility, Stanford, CA; Ngan Huang, Stanford Univ, Stanford, CA L. Hou: None. J. Kim: None. J. Coller: None. V. Natu: None. N. Huang: None. 358 First Trimester Human Umbilical Cord Perivascular Cells (FTM HUCPVCs) Maintain High Expression Levels of Angiogenic Factors and Have Superior Pro-angiogenic Effects on Endothelial Networks When Compared to Term HUCPVCs and BMSCs in an ex-vivo Rat Aortic Ring Assay Farwah Iqbal, Peter Szaraz, Shlomit Kenigsberg, Andree Gauthier-Fisher, Clifford Librach, Create Fertility Ctr, Toronto, ON, Canada F. Iqbal: None. P. Szaraz: None. S. Kenigsberg: None. A. Gauthier-Fisher: None. C. Librach: None. 359 The Production of Acellular Cardiac Extracellular Matrix from P3 Murine Heart Stefan M Kren, Daniel J Garry, Mary G Garry, Univ of Minnesota, Minneapolis, MN S.M. Kren: None. D.J. Garry: None. M.G. Garry: None. 360 Implantation of an Induced Pluripotent Stem Cell Derived Cardiomyocyte Tissue Engineered Patch Improves Left Ventricular Function and Electro-mechanical Coupling in Rats With Heart Failure Jordan J Lancaster, Giuliana Repetti, Amitabh Pandey, Kyle Weigand, Joseph J Bahl, Elizabeth Juneman, Steven Goldman, Univ of Arizona, Tucson, AZ J.J. Lancaster: None. G. Repetti: None. A. Pandey: None. K. Weigand: None. J.J. Bahl: None. E. Juneman: None. S. Goldman: None. 361 Creg1 Interacts With Sec8 to Promote Cell-cell Adhesion During Cardiomyogenesis Jie Liu, Yanmei Qi, Robert Wood Johnson Medical Sch, New Brunswick, NJ; Shu-Chan Hsu, Coll of Arts and Sciences, New Brunswick, NJ; Siavash Saadat, Saum Rahimi, Leonard Lee, Robert Wood Johnson Medical Sch, New Brunswick, NJ; Chenghui Yan, Xiaoxiang Tian, Yaling Han, the General Hosp of Shenyang Military Region, Shenyang, China; Shaohua Li, Robert Wood Johnson Medical Sch, New Brunswick, NJ J. Liu: None. Y. Qi: None. S. Hsu: None. S. Saadat: None. S. Rahimi: None. L. Lee: None. C. Yan: None. X. Tian: None. Y. Han: None. S. Li: None. 362 Deletion of Gata4 and Gata6 in the c-Kit Lineage Augments Cellular Fusion in vivo Bryan D Maliken, Onur Kanisicak, Jeffery D Molkentin, Cincinnati Children's Hosp, Cincinnati, OH B.D. Maliken: None. O. Kanisicak: None. J.D. Molkentin: None. 363 In Situ Cardiac Cellular Reprogramming Using Adenoviral Vectors: Implication for Clinical Myocardial Regeneration Megumi Mathison, Vivek P Singh, Baylor Coll of Med, Houston, TX; Maria J Chiuchiolo, Weill Cornell Medical Coll, New York, NY; Deepthi Sanagasetti, Yun Mao, Vivekkumar B Patel, Jianchang Yang, Baylor Coll of Med, Houston, TX; Stephen M Kaminsky, Ronald G Crystal, Weill Cornell

Medical Coll, New York, NY; Todd K Rosengart, Baylor Coll of Med, Houston, TX M. Mathison: None. V.P. Singh: None. M.J. Chiuchiolo: None. D. Sanagasetti: None. Y. Mao: None. V.B. Patel: None. J. Yang: None. S.M. Kaminsky: None. R.G. Crystal: None. T.K. Rosengart: None. 365 Comparison of Non-Human Primate- vs. Human iPSC-Derived Cardiomyocytes for Transplantation in Rodent Chronic Myocardial Infarction Model Xin Zhao, Dan Xiao, Haodong Chen, Alexandra Holmstrom, Tony Chour, Chun Liu, Huaxiao Yang, Xulei Qin, Evgenios Neofytou, Joseph C. Wu, Stanford Univ, Stanford, CA X. Zhao: None. D. Xiao: None. H. Chen: None. A. Holmstrom: None. T. Chour: None. C. Liu: None. H. Yang: None. X. Qin: None. E. Neofytou: None. J.C. Wu: None.

This research has received full or partial funding support from the American Heart Association. 366 Cardiac Strain from Magnetic Resonance Imaging Offers Sensitive Detection of Therapeutic Efficacy Following Transplantation of Tissue Engineered Heart Muscles Xulei Qin, Johannes Riegler, Stanford Univ, Stanford, CA; Malte Tiburcy, Georg-August-Univ and German Ctr for Cardiovascular Res, Göttingen, Germany; Thomas Denney Jr., Auburn Univ, Auburn, AL; Wolfram Zimmermann, Georg-August-Univ and German Ctr for Cardiovascular Res, Göttingen, Germany; Joseph Wu, Stanford Univ, Stanford, CA X. Qin: None. J. Riegler: None. M. Tiburcy: None. T. Denney Jr.: None. W. Zimmermann: None. J. Wu: None. 367 Combined Effect of Dinitrophenol Preconditioning and Jagged-1 Over-expression in Mesenchymal Stem Cells Improved Cardiomyogenesis and Angiogenesis in Rat Model of Myocardial Infarction Asmat Salim, Anwar Ali, Muhammad A Akhter, Irfan Khan, Nadia Naeem, Intl Ctr for Chemical and Biological Sciences (ICCBS), Karachi, Pakistan A. Salim: None. A. Ali: None. M.A. Akhter: None. I. Khan: None. N. Naeem: None. 368 Ex vivo Fabrication of Heart Tissue Model with Perfusable Blood Vessels Using Cell Sheet Hidekazu Sekine, Tatsuya Shimizu, Tokyo Women's Medical Univ, Tokyo, Japan H. Sekine: None. T. Shimizu: 7. Ownership Interest; Modest; CellSeed Inc. 369 Boosting Antioxidant Capacity Could Enhance Regenerative Ability of Cardiac Progenitors Derived From Embryonic Stem Cells Parisa Shabani, Zaniar Ghazizadeh, Royan Inst, Tehran, Iran, Islamic Republic of; Mahmood Doosti, Tehran Univ of Medical Sciences, Tehran, Iran, Islamic Republic of; Hossein Baharvand, Nasser Aghdami, Royan Inst, Tehran, Iran, Islamic Republic of P. Shabani: None. Z. Ghazizadeh: None. M. Doosti: None. H. Baharvand: None. N. Aghdami: None. 370 Hedgehog Signaling Regulates Cardiac Regeneration in vivo Bhairab N Singh, Wuming Gong, Mary G Garry, Naoko Koyano-Nakagawa, Daniel J Garry, Lillehei Heart Inst, Minneapolis, MN B.N. Singh: None. W. Gong: None. M.G. Garry: None. N. Koyano-Nakagawa: None. D.J. Garry: None.


AB

ST

RA

CT

S

This research has received full or partial funding support from the American Heart Association. 371 The Role of Survivin in Cardiac Regeneration Tien-Jui Tsang, Academia Sinica, Taipe, Taiwan T. Tsang: None. 372 MicroRNA-9 Inhibits Hyperglycemia-induced Cardiac Pyroptosis by Targeting ELAVL1 Prince Jeyabal, Rajarajan A Thandavarayan, Darukeshwara Joladarashi, Sahana Suresh Babu, Shashirekha Krishnamurthy, Houston Methodist Res Inst, Houston, TX; Arvind Bhimaraj, Keith A Youker, Houston Methodist Hosp, Houston, TX; Raj Kishore, Temple Univ, Philadelphia, PA; Prasanna Krishnamurthy*, Houston Methodist Res Inst, Houston, TX P. Jeyabal: None. R.A. Thandavarayan: None. D. Joladarashi: None. S. Suresh Babu: None. S. Krishnamurthy: None. A. Bhimaraj: None. K.A. Youker: None. R. Kishore: None. P. Krishnamurthy*: None.

This research has received full or partial funding support from the American Heart Association. 373 Identification of Novel Anti-necrotic Factor TGN91 Jason Karch, Matthew J Brody, Onur Kanisicak, Michelle A Sargent, Jeffery D Molkentin, Cincinnati Children's Hosp Medical Ctr, Cincinnati, OH J. Karch: None. M.J. Brody: None. O. Kanisicak: None. M.A. Sargent: None. J.D. Molkentin: None. 374 FGF2 Isoform-selective as well as Non-selective Signals Protect Cardiomyocytes from Doxorubicin-induced Cell Death Navid Koleini, Dept of Physiology and Pathophysiology, Univ of Manitoba, Winnipeg, MB, Canada; Barbara E Nickel, Robert R Fandrich, Inst of Cardiovascular Sciences, Winnipeg, MB, Canada; Lorrie A Kirshenbaum, Peter A Cattini, Dept of Physiology and Pathophysiology, Univ of Manitoba, Winnipeg, MB, Canada; Elissavet Kardami, Dept of Human Anatomy and Cell Sciences, Univ of Manitoba, Winnipeg, MB, Canada N. Koleini: None. B.E. Nickel: None. R.R. Fandrich: None. L.A. Kirshenbaum: None. P.A. Cattini: None. E. Kardami: None. 375 MCL-1 Regulates Mitochondrial Dynamics and Mitophagy Alexandra G Moyzis, Leonardo Leon, Robert L. Thomas, Åsa B. Gustafsson, Univ of California, San Diego, La Jolla, CA A.G. Moyzis: None. L. Leon: None. R.L. Thomas: None. Å.B. Gustafsson: None.

This research has received full or partial funding support from the American Heart Association. 376 Sam68 Suppresses Autophagy in Macrophages and Promotes Atherosclerosis Jiawei Shi, Shuling Han, Junlan Zhou, Liu Yang, Baron Arnone, Chan Boriboun, FCVRI, Northwestern Univ, Chicago, IL; Congcong He, Dept of Cell and Molecular Biology, Northwestern Universtiy, Chicago, IL; Gangjian Qin, FCVRI, Northwestern Univ, Chicago, IL J. Shi: None. S. Han: None. J. Zhou: None. L. Yang: None. B. Arnone: None. C. Boriboun: None. C. He: None. G. Qin: None.

377 A Systematic Review of Medication Adherence Among African American Heart Failure Patients Lila de Tantillo, Rosa M Gonzalez-Guarda, Univ of Miami, Coral Gables, FL L. de Tantillo: None. R.M. Gonzalez-Guarda: None. 378 Cholecystokinin Upregulates Cholesterol Absorption in Human Intestinal Epithelial Cells Zhongmao Guo, Ningya Zhang, Lemuel Dent, Emmanuel U Okoro, Hong Yang, Meharry Medical Coll, Nashville, TN Z. Guo: 2. Research Grant; Significant; U54MD0007593, UL1TR000445. N. Zhang: None. L. Dent: None. E.U. Okoro: None. H. Yang: 2. Research Grant; Modest; SC1HL101431. 379 The Prognostic Value of Eosinophil to Leukocyte Ratio in Patients Presenting with ST-elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention Takao Konishi, Naohiro Funayama, Tadashi Yamamoto, Daisuke Hotta, Hokkaido Cardiovascular Hosp, Sapporo, Japan T. Konishi: None. N. Funayama: None. T. Yamamoto: None. D. Hotta: None. 380 Impairment of Human Microvascular Function Induced by β-amyloid and Cardiovascular Risk Factors Seth Truran, Nina Karamanova, Phoenix VA, Phoenix, AZ; Jenna Anderson, Univ of Arizona, Phoenix VA, Phoenix, AZ; Geidy Serrano, Thomas Beach, Banner Sun Health Res Inst, Phoenix, AZ; Daniel Franco, Camelia Burciu, Phoenix VA, Phoenix, AZ; Peter Reaven, Raymond Migrino, Phoenix VA, Univ of Arizona, Phoenix, AZ S. Truran: None. N. Karamanova: None. J. Anderson: 2. Research Grant; Modest; AHA Summer Student grant. G. Serrano: None. T. Beach: 2. Research Grant; Significant; NINDS U24NS072026, NIA P30AG19610, NIA RO1AG019795, Arizona Department of Health Services (contrast 211002), Arizona Biomedical Research Commission (4001, 0011, 05-901 and 1001), Michael J. Fox Foundation for Parkinson’s Research and Amyloidosis Foundation. D. Franco: None. C. Burciu: None. P. Reaven: None. R. Migrino: 2. Research Grant; Significant; National Institutes Health (NIA R21AG044723), Veterans Affairs Merit grant (I01BX007080).

This research has received full or partial funding support from the American Heart Association. 382 Cell Type-specific Fibroblast Growth Factor Receptors That are Regulated in Human Heart Disease Angela K. Peter, Darrian N. Bugg, Christopher D. Ozeroff, CU Boulder, Boulder, CO; Michel Chonchol, Amrut V. Ambardekar, CU Denver, Aurora, CO; Rahul Kakkar, AstraZeneca, London, United Kingdom; Leslie A. Leinwand, CU Boulder, Boulder, CO A.K. Peter: 3. Other Research Support; Significant; AstraZeneca. D.N. Bugg: 3. Other Research Support; Significant; AstraZeneca. C.D. Ozeroff: 3. Other Research Support; Significant; AstraZeneca. M. Chonchol: None. A.V. Ambardekar: None. R. Kakkar: None. L.A. Leinwand: 3. Other Research Support; Significant; AstraZeneca.


AB

ST

RA

CT

S

383 Immunotherapy with Trypanosoma cruzi Genes Prevents the Severity of Heart Damage in Experimental Chagasic Dogs Evaluated by Electrocardiography and Macroscopic Findings at Necropsy Olivia Rodríguez-Morales, Silvia C. Carrillo-Sánchez, Martha Rios-Castro, Minerva Arce-Fonseca, Insto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico O. Rodríguez-Morales: None. S.C. Carrillo-Sánchez: None. M. Rios-Castro: None. M. Arce-Fonseca: None. 384 Evaluating Late Sodium Current in Human Induced Pluripotent Stem Cell Derived Cardiomyocytes Derek Schocken, Jayna Stohlman, FDA, Silver Spring, MD; Xiaoyu Zhang, Yama Abassi, ACEA Biosciences, San Diego, CA; Lars Johannesen, Jose Vicente, David Strauss, Ksenia Blinova, FDA, Silver Spring, MD D. Schocken: None. J. Stohlman: None. X. Zhang: 1. Employment; Significant; ACEA Biosciences. Y. Abassi: 1. Employment; Significant; ACEA Biosciences. L. Johannesen: None. J. Vicente: None. D. Strauss: None. K. Blinova: None. 385 Broccoli Sprout Extracts Prevents Diabetic Cardiomyopathy in db/db Mice: The Importance of Up-regulated Nrf2 Expression and Function Zheng xu, Yi Tan, Pediatrics of the Univ of Louisville, Louisville, KY; Jian Sun, The First Hosp of Jilin Univ, Changchun, China, Changchun, China; Lu Cai, Pediatrics of the Univ of Louisville, Louisville, KY Z. xu: None. Y. Tan: None. J. Sun: None. L. Cai: None. 386 Notch1 Signaling Negatively Modulates Repolarizing Kv Currents in Cardiomyocytes Giulia Borghetti, Sergio Signore, Andrea Sorrentino, Polina Goichberg, Brigham and Women's Hosp, Boston, MA; Marcello Rota, New York Medical Coll, Valhalla, NY G. Borghetti: None. S. Signore: None. A. Sorrentino: None. P. Goichberg: None. M. Rota: None. 387 Cardiac Myosin-binding Protein C Structural Dynamics - a Time-resolved FRET Biosensor for Enhanced Contractility in Heart Failure Therapeutic Discovery Thomas A Bunch, Victoria C Lepak, Brett A Colson, Univ of Arizona, Tucson, AZ T.A. Bunch: None. V.C. Lepak: None. B.A. Colson: None. 388 Functional Role of Inositol 1,4,5-Trisphosphate Receptors in Cardiac Hypertrophy Martha Iveth Garcia, Univ of Texas Medical Branch, Galveston, TX M. Garcia: None. 389 Amino Terminal Region of Cardiac Myosin Binding Protein-C is Necessary for Cardiac Function Thomas L. Lynch IV, Diederik W Kuster, Loyola Univ Chicago, Maywood, IL; Mayandi Sivaguru, Univ of Illinois at Urbana-Champaign, Urbana, IL; Michael J. Previs, Cardiovascular Res Inst of Vermont, Burlington, VT; Kyounghwan Lee, Univ of Massachusetts Medical Sch, Worcester, MA; Suresh Govindan, Loyola Univ Chicago, Maywood, IL; Roger Craig, Univ of Massachusetts Medical Sch, Worcester, MA; David M. Warshaw, Cardiovascular Res Inst of Vermont, Burlington, VT; Sakthivel Sadayappan, Loyola Univ Chicago, Maywood, IL T.L. Lynch: None. D.W.D. Kuster: None. M. Sivaguru: None. M.J. Previs: None. K. Lee: None. S. Govindan: None. R. Craig: None. D.M. Warshaw: None. S. Sadayappan: None.

390 Dysregulation of ATF2 in Dilated Cardiomyopathy Caused by FBXO32 Mutation Nadya Alyacoub, Salma Awad, Mohmad Kunhi, King Faisal Specialist Hosp & Res Ctr, Riyadh, Saudi Arabia; Walid Al-Habeeb, King Saud Univ, Riyadh, Saudi Arabia; Coralie Poizat, King Faisal Specialist Hosp & Res Ctr, Riyadh, Saudi Arabia N. Alyacoub: None. S. Awad: None. M. Kunhi: None. W. Al-Habeeb: None. C. Poizat: None. 391 The Pathophysiological Role of MYBPHL in Dilated Cardiomyopathy David Y Barefield, Megan J Puckelwartz, Lisa Dellefave-Castillo, Elizabeth M McNally, Northwestern Univ, Chicago, IL D.Y. Barefield: None. M.J. Puckelwartz: None. L. Dellefave-Castillo: None. E.M. McNally: None. 392 Decreased ARNT Mediates Cardiovascular Endothelial Dysfunction in Diabetic Cardiomyopathy Maura Knapp, Mei Zheng, Hao Huang, James K Liao, Rongxue Wu, Univ of Chicago, Chicago, IL M. Knapp: None. M. Zheng: None. H. Huang: None. J. Liao: None. R. Wu: None.

This research has received full or partial funding support from the American Heart Association. 393 The Intercalated Disc Protein Myozap: A Novel Player in Cardiac Proteinopathy Ashraf Y Rangrez, Derk Frank, Univ Medical Ctr Campus Kiel, Kiel, Germany; Liam Cassidy, Christian-Albrechts Univ of Kiel, Kiel, Germany; Lynn Christen, Univ Medical Ctr Campus Kiel, Kiel, Germany; Inka Geurink, Christian-Albrechts Univ of Kiel, Kiel, Germany; Alexander Bernt, Univ Medical Ctr Campus Kiel, Kiel, Germany; Martina Böttner, Christian-Albrechts Univ of Kiel, Kiel, Germany; Hendrik Milting, Ruhr Univ Bochum, Bad Oeynhausen, Germany; Andreas Tholey, Christian-Albrechts Univ of Kiel, Kiel, Germany; Jeffrey Robbins, Children's Hosp Medical Ctr, Cincinnati, OH; Norbert Frey, Univ Medical Ctr Campus Kiel, Kiel, Germany A.Y. Rangrez: None. D. Frank: None. L. Cassidy: None. L. Christen: None. I. Geurink: None. A. Bernt: None. M. Böttner: None. H. Milting: None. A. Tholey: None. J. Robbins: None. N. Frey: None. 394 Multiple Cellular Mechanisms Underlie the Trafficking-deficient Phenotype for Kv11.1 (hERG) Mutations Linked to Long QT Syndrome Jennifer L Smith, Allison R. Reloj, Corey L. Anderson, Craig T. January, Brian T. Delisle, Univ of Kentucky, Lexington, KY J.L. Smith: None. A.R. Reloj: None. C.L. Anderson: None. C.T. January: None. B.T. Delisle: None.

This research has received full or partial funding support from the American Heart Association. 395 Voluntary Exercise Enhances Cardiac Growth in Response to Chronic β-Adrenergic Receptor Stimulation Stephen W Luckey, Nathan McLaughlin, Sherilynn Soo, Seattle Univ, Seattle, WA S.W. Luckey: None. N. McLaughlin: None. S. Soo: None.


AB

ST

RA

CT

S

396 Regulation of Cardiomyocyte Proliferation by the Hippo Pathway and Dystrophin Complex Yuka Morikawa, Texas Heart Inst, Houston, TX; John Leach, Baylor Coll of Med, Houston, TX; Todd Heallen, Texas Heart Inst, Houston, TX; Ge Tao, James F Martin, Baylor Coll of Med, Houston, TX Y. Morikawa: None. J. Leach: None. T. Heallen: None. G. Tao: None. J.F. Martin: None.

This research has received full or partial funding support from the American Heart Association. 397 Regional Differences in Periaortic Adipose Tissue Khanh-Van Tran, Timothy Fitzgibbons, Silvia Corvera, UMass Medical Ctr, Worcester, MA K. Tran: None. T. Fitzgibbons: None. S. Corvera: None. 398 Alternative Splicing of Titin Restores Diastolic Function and Improves HFpEF Associated Symptoms Mathew Bull, Mei Methawasin, Joshua Strom, Pooja Nair, Kirk Hutchinson, Henk Granzier, The Univ of Arizona, Tucson, AZ M. Bull: None. M. Methawasin: None. J. Strom: None. P. Nair: None. K. Hutchinson: None. H. Granzier: None. 399 End-stage Heart Failure Causes Severe Lung Fibrosis and Dysfunction Xiaohong Liu, Shanxi Provincial People’s Hosp, Taiyuan, China; Huan Wang, Univ Minnesota, Minneapolis, MN; Ruru Shang, Jin Zhang, Shanxi Provincial People’s Hosp, Taiyuan, China; Yingjie Chen, Univ Minnesota, Minneapolis, MN X. Liu: None. H. Wang: None. R. Shang: None. J. Zhang: None. Y. Chen: None. 400 Role of the 17beta-Estradiol/beta-Catenin Axis in Heart Failure Georgios Kararigas, Charite Univ Hosp, Berlin, Germany; Laura C Zelarayan, Karl Toischer, Gerd Hasenfuss, Hubertus Jarry, Georg-August-Univ Goettingen, Goettingen, Germany; Vera Regitz-Zagrosek, Charite Univ Hosp, Berlin, Germany G. Kararigas: None. L.C. Zelarayan: None. K. Toischer: None. G. Hasenfuss: None. H. Jarry: None. V. Regitz-Zagrosek: None. 401 The γ2-AMPK Regulates Glucose and Glycogen Metabolism in the Heart by Modulating Cytosolic Hexokinase II Level Maengjo Kim, Mayo Clinic, Rochester, MN; Lorena Garcia-Menendez, Yong Seon Choi, Univ of Washington, Seattle, WA; Birthe Roos, Mirjam M Wamelink, VU Univ Medical Ctr, Amsterdam, Netherlands; Haiwei Gu, Lauren Abell, Daniel Raftery, Richard D Palmiter, Rong Tian, Univ of Washington, Seattle, WA M. Kim: None. L. Garcia-Menendez: None. Y. Choi: None. B. Roos: None. M.M.C. Wamelink: None. H. Gu: None. L. Abell: None. D. Raftery: None. R.D. Palmiter: None. R. Tian: None.


402 Mutation-Specific Activation of CaMK-II in Hypertrophic Cardiomyopathy Sarah J Lehman, Univ of Arizona, Tucson, AZ; Lauren Tal-Grinspan, Albert Einstein Coll of Med, Bronx, NY; Amanda Richards, Nora Bedrossian, Univ of Arizona, Tucson, AZ; Mark E. Anderson, Univ of Iowa, Iowa City, IA; Jil C Tardiff, Univ of Arizona, Tucson, AZ S.J. Lehman: None. L. Tal-Grinspan: None. A. Richards: None. N. Bedrossian: None. M.E. Anderson: None. J.C. Tardiff: None. 403 Critical Role for Dipeptidyl Peptidase-4 Activity in the Pathogenesis of Experimental Autoimmune Myocarditis Yasuhiro Maejima, Yusuke Ito, Natsuko Tamura, Mitsuaki Isobe, Tokyo Medical and Dental Univ, Bunkyo-ku, Japan Y. Maejima: None. Y. Ito: None. N. Tamura: None. M. Isobe: None.

This research has received full or partial funding support from the American Heart Association. 404 FK506-binding Protein 38 Protects the Heart From Pressure Overload-induced Cardiac Dysfunction via Endoplasmic Reticulum-associated Apoptosis Tomofumi Misaka, Tomokazu Murakawa, Kazuhiko Nishida, Kinya Otsu, King's Coll London, London, United Kingdom T. Misaka: None. T. Murakawa: None. K. Nishida: None. K. Otsu: None. 405 Unprocessed ProBNP Secretion is Regulated by miR30-GALNTs Axis Dependent O-glycosylation in the Pathological Myocardium Yasuaki Nakagawa, Koichiro Kuwahara, Toshio Nishikimi, Hideyuki Kinoshita, Chinatsu Yamada, Hideaki Inazumi, Kazuwa Nakao, Takeshi Kimura, Kyoto Graduate Sch of Med, Kyoto, Japan Y. Nakagawa: 3. Other Research Support; Modest; Shionogi pharmaceutical company. K. Kuwahara: None. T. Nishikimi: None. H. Kinoshita: None. C. Yamada: None. H. Inazumi: None. K. Nakao: None. T. Kimura: None. 406 Oxidative Stress Mediated Myocardial Lipid Dysfunction Manikandan Panchatcharam, Mini Chandra, Jonathan Fox, Shenuarin Bhuiyan, Wayne Orr, Christopher Kevil, Jonathan Steven Alexander, LSU Health Sciences Ctr - Shreveport, Shreveport, LA; Joseph C Wu, Stanford Cardiovascular Inst, Shreveport, CA; Diana Escalante-Alcalde, Insto de Fisiologia Celular, Mexico, Mexico; Sumitra Miriyala, LSU Health Sciences Ctr - Shreveport, Shreveport, LA M. Panchatcharam: None. M. Chandra: None. J. Fox: None. S. Bhuiyan: None. W. Orr: None. C. Kevil: None. J. Alexander: None. J.C. Wu: None. D. Escalante-Alcalde: None. S. Miriyala: None. 407 Overexpression of the Valosin-containing Protein in vivo Prevents Cardiac Hypertrophy and Heart Failure by Chronic Pressure Overload via Suppressing the Activation of mTORC1 Pathway Ning Zhou, Ben Ma, Tristen T Hays, Hongyu Qiu, Loma Linda Unviersity, Loma Linda, CA N. Zhou: None. B. Ma: None. T.T. Hays: None. H. Qiu: None.


AB

ST

RA

CT

S

408 The Role of the Chemokine Receptor CXCR3 - Integrin Lymphocyte Function Associated Antigen 1 (LFA1) - Intercellular Adhesion Molecule 1 (ICAM1) Axis in T Lymphocyte Mediated Cardiac Inflammation in Pressure Overload Induced Heart Failure Ane Miren Salvador, Tania Nevers, Francisco Velazquez, Mark Aronovitz, Pilar Alcaide, Tufts Medical Ctr, Boston, MA A. Salvador: None. T. Nevers: None. F. Velazquez: None. M. Aronovitz: None. P. Alcaide: None. 409 Matrix Metalloproteinase-13 Inhibition is Protective in a Pressure Overload Model of Heart Failure Allison E Schafer, Iñigo Valiente-Alandi, Burns C Blaxall, Cincinnati Children's Hopsital Medical Ctr, Cincinnati, OH A.E. Schafer: None. I. Valiente-Alandi: None. B.C. Blaxall: None. 410 Novel Sulfonylhydrazone Derivative Prevents Cardiac and Vascular Remodeling in Rats With Streptozotocin-induced Diabetes Roberto T Sudo, Josenildo S Araujo, Ananssa M Silva, Allan K Alencar, Mateus S Delgobbo, Thiago F Silva, Univ Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Margarete M Trachez, Univ Federal Fluminense, Rio de Janeiro, Brazil; Lidia M Lima, Eliezer J Barreiro, Gisele Zapata-Sudo, Univ Federal do Rio de Janeiro, Rio de Janeiro, Brazil R.T. Sudo: 2. Research Grant; Modest; CAPES, CNPq, FAPERJ, INCT-INOFAR. J.S.C. Araujo: None. A.M.S. Silva: None. A.K.N. Alencar: None. M.S. Delgobbo: None. T.F. Silva: None. M.M. Trachez: None. L.M. Lima: None. E.J. Barreiro: None. G. Zapata-Sudo: 2. Research Grant; Modest; CAPES, CNPq, FAPERJ, INCT-INOFAR. 411 In Utero Exposure to PM2.5 Causes Adult Cardiovascular Dysfunction and Reduced Exercise Capacity Vineeta Tanwar, Kristin I Stanford, Loren E Wold, The Ohio State Univ, Columbus, OH V. Tanwar: None. K.I. Stanford: None. L.E. Wold: None. 412 Global Phosphopeptide Analyses Identifies a Profile that Distinguishes Advanced Heart Failure Patients Capable of Cardiac Recovery Following Left Ventricular Assist Device Unloading Christopher M Tracy, Aman Makaju, Sutip Navankasattusas, Lauren McCreath, Nikolaos Diakos, Craig Selzman, Stavros Drakos, Sarah Franklin, Univ of Utah, Salt Lake City, UT C.M. Tracy: None. A. Makaju: None. S. Navankasattusas: None. L. McCreath: None. N. Diakos: None. C. Selzman: None. S. Drakos: None. S. Franklin: None. 414 Putative Role of MicroRNA-143 in Modulating Natriuretic Peptide Signaling via Down-regulation of the Expression of Natriuretic Peptide Receptor 3 Juan Wang, Lee Lee Wong, Arthur Mark Richards, Yei-Tsung Chen, Cardiovascular Res Inst, Natl Univ Health System, Singapore, Singapore J. Wang: None. L.L. Wong: None. A.M. Richards: None. Y. Chen: None. 416 Pluripotent Stem Cell Signaling in Pediatric Heart Failure Patients Kathleen C Woulfe, Phillip Tatman, Anis Karimpour-Fard, Xuan Jiang, Karin Nunley, Shelley D Miyamoto, Brian L Stauffer, Carmen C Sucharov, Univ of Colorado, Aurora, CO

K.C. Woulfe: None. P. Tatman: None. A. Karimpour-Fard: None. X. Jiang: None. K. Nunley: None. S.D. Miyamoto: None. B.L. Stauffer: None. C.C. Sucharov: None.

This research has received full or partial funding support from the American Heart Association. 417 BET Bromodomain Inhibition Blunts Heart Failure Progression and Fibrosis in Genetic Cardiomyopathy Michael A Burke, Emory Univ Sch of Med, Atlanta, GA; Hiroko Wakimoto, Joshua M Gorham, David A Conner, Jonathan G Seidman, Harvard Medical Sch, Boston, MA; James E. Bradner, Dana Farber Cancer Inst, Boston, MA; Saptarsi M Haldar, Gladstone Inst of Cardiovascular Disease, San Francisco, CA; Jonathan D Brown, Vanderbilt Sch of Med, Nashville, TN; Christine E Seidman, Harvard Medical Sch, Boston, MA M.A. Burke: None. H. Wakimoto: None. J.M. Gorham: None. D.A. Conner: None. J.G. Seidman: None. J.E. Bradner: 7. Ownership Interest; Significant; Founder, Tensha Therapeutics. S.M. Haldar: None. J.D. Brown: None. C.E. Seidman: None. 419 Conserved Age-associated Cytoskeletal Remodeling Improves Cardiac Function and Lifespan Gaurav Kaushik, Alice Spenlehauer, Ayla O. Sessions, UC San Diego, La Jolla, CA; Adriana S. Trujillo, San Diego State Univ, San Diego, CA; Alexander Fuhrmann, UC San Diego, La Jolla, CA; Zongming Fu, Johns Hopkins Univ, Baltimore, MD; Vidya Venkatraman, Cedars-Sinai Medical Ctr, Los Angeles, CA; Danielle Pohl, Jeremy Tuler, UC San Diego, La Jolla, CA; Mingyi Wang, Edward G. Lakatta, Natl Inst on Aging, Baltimore, MD; Karen Ocorr, Rolf Bodmer, Sanford-Burnham-Prebys Medical Discovery Inst, La Jolla, CA; Sanford I. Bernstein, San Diego State Univ, San Diego, CA; Jennifer E. Van Eyk, Cedars-Sinai Medical Ctr, Los Angeles, CA; Anthony Cammarato, Johns Hopkins Univ, Baltimore, MD; Adam J. Engler, UC San Diego, La Jolla, CA G. Kaushik: None. A. Spenlehauer: None. A.O. Sessions: None. A.S. Trujillo: None. A. Fuhrmann: None. Z. Fu: None. V. Venkatraman: None. D. Pohl: None. J. Tuler: None. M. Wang: None. E.G. Lakatta: None. K. Ocorr: None. R. Bodmer: None. S.I. Bernstein: None. J.E. Van Eyk: None. A. Cammarato: None. A.J. Engler: None.

This research has received full or partial funding support from the American Heart Association. 420 The Mir-1954 Regulates Cardiac Remodeling by Targeting Sp1-Gata4-Tsp1 Signaling Sudhiranjan Gupta, Li Li, Cardiovascular Res Inst, Temple, TX S. Gupta: None. L. Li: None.

This research has received full or partial funding support from the American Heart Association. 421 Activated Cardiac Myofibroblasts Can Revert Back to Become Resident Fibroblasts Upon Injury Cessation Onur Kanisicak, Jason Karch, Hadi Khalil, Bryan Maliken, Jeffery D. Molkentin, Children's Hosp Medical Ctr, Cincinnati, OH O. Kanisicak: None. J. Karch: None. H. Khalil: None. B. Maliken: None. J.D. Molkentin: None.



AB

ST

RA

CT

S

422 CITED4 is Sufficient to Induce Physiologic Cardiac Hypertrophy and Necessary to Protect Against Pathological Hemodynamic Stress Carolin Lerchenmueller, Massachusetts General Hosp, Boston, MA; Vassilios J Bezzeridis, Boston Children's Hosp, Boston, MA; Colin Platt, Chunyang Xiao, Anthony Rosenzweig, Massachusetts General Hosp, Boston, MA C. Lerchenmueller: None. V.J. Bezzeridis: None. C. Platt: None. C. Xiao: None. A. Rosenzweig: None. 423 Kinase Independent Signaling of PI3Kγ Mediates Cardiac Fibrosis Maradumane L Mohan, Lisa M Grove, Mitchell A Olman, Sathyamangla V Naga Prasad, Cleveland Clinic, Cleveland, OH M.L. Mohan: None. L.M. Grove: None. M.A. Olman: None. S.V. Naga Prasad: None.

This research has received full or partial funding support from the American Heart Association. 424 Effector T Cells Induce Cardiac Fibroblasts Transition to Myofibroblasts & Contribute to Pressure Overload Induced Cardiac Fibrosis Tania A Nevers, Ane Salvador, Tufts Medical Ctr, Boston, MA; Francisco Velazquez, Tufts Univ, Boston, MA; Mark Aronovitz, Robert Blanton, Tufts Medical Ctr, Boston, MA T.A. Nevers: None. A. Salvador: None. F. Velazquez: None. M. Aronovitz: None. R. Blanton: None. 425 Doxorubicin Upregulation of the Fibrotic Transforming Growth Factor-beta Pathway Trevi A Ramirez, Greg Aune, UT Health Science Ctr San Antonio, San Antonio, TX T.A. Ramirez: None. G. Aune: None. 426 Laminin Downregulation Facilitates Cardiomyocyte Coupling in situ to Increase Contractile Function Ayla Sessions, Gaurav Kaushik, Adam Engler, Univ of California, San Diego, La Jolla, CA A. Sessions: None. G. Kaushik: None. A. Engler: None.

This research has received full or partial funding support from the American Heart Association. 427 Tissue Inhibitor of Matrix Metalloproteinase-3 (TIMP3) Provides Beneficial Effects Post-MI by Promoting Angiogenesis Abhijit R Takawale, Pu Zhang, Ratnadeep Basu, Abul Azad, Maikel Farhan, Xiuhua Wang, Allan Murray, Zamaneh Kassiri, Univ of Alberta, Edmonton, AB, Canada A.R. Takawale: None. P. Zhang: None. R. Basu: None. A. Azad: None. M. Farhan: None. X. Wang: None. A. Murray: None. Z. Kassiri: None. 428 Pharmacologic and Activated Fibroblast-specific Gβγ-GRK2 Inhibition is Protective Following Ischemia Reperfusion Injury Joshua G Travers, Fadia A Kamal, Cincinnati Children's Hosp Medical Ctr, Cincinnati, OH; Michelle L Nieman, Univ of Cincinnati, Cincinnati, OH; Michelle A Sargent, Jeffery D Molkentin, Burns C Blaxall, Cincinnati Children's Hosp Medical Ctr, Cincinnati, OH J.G. Travers: None. F.A. Kamal: None. M.L. Nieman: None. M.A. Sargent: None. J.D. Molkentin: None. B.C. Blaxall: None.

429 Thoracic Aortic Smooth Muscle Cell Phenotype and Contractility are Altered with Aging Jason B Wheeler, Robert E. Stroud, Elizabeth K. Nadeau, Rupak Mukherjee, John S. Ikonomidis, Jeffrey A. Jones, Medical Univ of South Carolina, Charleston, SC J.B. Wheeler: None. R.E. Stroud: 2. Research Grant; Significant; R01 AG036954, R01 HL102121, IO1 BX000904, I21 RX001707. E.K. Nadeau: None. R. Mukherjee: 2. Research Grant; Significant; R01 AG036954, R01 HL102121, IO1 BX000904, I21 RX001707. J.S. Ikonomidis: 2. Research Grant; Significant; R01 AG036954, R01 HL102121, IO1 BX000904, I21 RX001707. J.A. Jones: 2. Research Grant; Significant; R01 AG036954, R01 HL102121, IO1 BX000904, I21 RX001707. 430 Spectral Changes Caused by Radiofrequency Ablation of Cardiac Tissue Mohammed Aljishi, Huda Asfour, Tigran Chahbazian, Narine Muselimyan, Luther Swift, Marco Mercader, Narine Sarvazyan, George Washington Univ, Washington, DC M. Aljishi: None. H. Asfour: None. T. Chahbazian: None. N. Muselimyan: None. L. Swift: 3. Other Research Support; Modest; LuxCath GW Research agreement. M. Mercader: 2. Research Grant; Modest; NIH STTR HL120511 award. 3. Other Research Support; Modest; LuxCath GW Research agreement. N. Sarvazyan: 2. Research Grant; Modest; NIH STTR HL120511 award. 3. Other Research Support; Modest; LuxCath GW Research agreement. 431 Mitochondrial Fission in the Heart is an Adaptation to Increased Energetic Demands: The Role of Physiologic Fragmentation Michael Coronado, Giovanni Fajardo, Kim Nguyen, Mingming Zhao, Kristina Bezold Kooiker, Gwanghyun Jung, Dong-Qing Hu, Sushma Reddy, Erik Sandoval, Stanford Univ, Stanford, CA; Aleksandr Stotland, Roberta Gottlieb, Cedars-Sinai Medical Ctr, Los Angeles, CA; Daniel Bernstein, Stanford Univ, Stanford, CA M. Coronado: None. G. Fajardo: None. K. Nguyen: None. M. Zhao: None. K. Bezold Kooiker: None. G. Jung: None. D. Hu: None. S. Reddy: None. E. Sandoval: None. A. Stotland: None. R. Gottlieb: None. D. Bernstein: None. 432 Elamipretide (BendaviaTM) Restores Aldehyde Dehydrogenase-2 Protein Levels and 4-Hydroxy-2-Nonenal Protein Adducts in Left Ventricular Myocardium of Dogs with Heart Failure Ramesh C Gupta, Vinita Singh-Gupta, Hani N Sabbah, Henry Ford Hosp, Detroit, MI R.C. Gupta: None. V. Singh-Gupta: None. H.N. Sabbah: None. 433 Mitochondrial Nadp-dependent Isocitrate Dehydrogenase is a Key Regulator in Vasomotor Function Cuk-Seong Kim, Saet-byel Jung, Chungnam Natl Univ., Daejeon, Korea, Republic of C. Kim: None. S. Jung: None. 434 Sirt4 Accelerates Ang II-induced Pathological Cardiac Hypertrophy by Inhibiting Mnsod Activity Depei Liu, Yu-Xuan Luo, Xiaoqiang Tang, Xi-Zhou An, Xue-Min Xie, Xiao-Feng Chen, Xiang Zhao, De-Long Hao, Hou-Zao Chen, Chinese Acad of Medical Sciences & Peking Union Medical Coll, Beijing, China


AB

ST

RA

CT

S

D. Liu: None. Y. Luo: None. X. Tang: None. X. An: None. X. Xie: None. X. Chen: None. X. Zhao: None. D. Hao: None. H. Chen: None. 435 The Mitochondrial Calcium Uniporter is Necessary for Cardiac Energetic Signaling During Chronic Stress Timothy S Luongo, John W Elrod, Temple Univ, Philadelphia, PA T.S. Luongo: None. J.W. Elrod: None.

This research has received full or partial funding support from the American Heart Association. 436 Mfn2 is a Nodal Point Regulatory Step That Coordinates Angiogenic Phenotype in the Vascular Endothelium Gladys A Nchaw, Kyriakos N. Papanicolaou, Jennifer L. Parker-Duffen, Ramon G. Bonegio, Kenneth Walsh, Boston Univ, Boston, MA G.A. Nchaw: None. K.N. Papanicolaou: None. J.L. Parker-Duffen: None. R.G. Bonegio: None. K. Walsh: None. 437 Increasing Cardiac Fatty Acid Oxidation Protects Against High Fat Diet Induced Cardiomyopathy in Mice Dan Shao, Nathan Roe, Loreta De Tomasi, Alyssa Noriko Braun, Ana Mattos, Stephen Kolwicz, Rong Tian, Univ of Washington, Seattle, WA D. Shao: None. N. Roe: None. L.D. Tomasi: None. A.N. Braun: None. A. Mattos: None. S. Kolwicz: None. R. Tian: None. 438 Hydrogen Sulfide Promotes Mitochondrial Biogenesis Through the Regulation of AMP-activated Protein Kinase Yuuki Shimizu, Rohini Polavarapu, John Calvert, Emory Univ, Atlanta, GA Y. Shimizu: None. R. Polavarapu: None. J. Calvert: None. 439 Modeling Diabetic Cardiomyopathy Model Using Human Induced Pluripotent Stem Cell-derived Cardiomyocytes Yuichi Horikoshi, Anna Williams, Xiaowen Bai, Yasheng Yan, Wai-Meng Kwok, Zeliko Bosnjak, Medical Coll of Wisconsin, Wauwatosa, WI Y. Horikoshi: None. A. Williams: None. X. Bai: None. Y. Yan: None. W. Kwok: None. Z. Bosnjak: None. 441 Role of the Mitochondrial Translocator Protein (TSPO) in the Proarrhythmic Vulnerability of the Diabetic Heart Jun Hu, Won-Joon Koh, Chaoqin Xie, Fadi G Akar, Icahn Sch of Med at Mount Sinai, New York, NY J. Hu: None. W. Koh: None. C. Xie: None. F.G. Akar: None.

This research has received full or partial funding support from the American Heart Association. 442 Intralipid Protects the Heart in Late Pregnancy Against Ischemia/Reperfusion Injury by Reducing Cardiomyocyte Apoptosis via Mir122 Induction Jingyuan Li, Negar Motayagheni, Neusha Barakati, Mansoureh Eghbali, UCLA, Los Angeles, CA J. Li: None. N. Motayagheni: None. N. Barakati: None. M. Eghbali: 2. Research Grant; Modest; NIH-HL119886.

443 Class I Histone Deacetylases Mediate Cardiac I/R Injury and Modify the Mitochondrial Acetylome Daniel J Herr, Sverre E Aune, Jennifer R Bethard, Lauren E Ball, Donald R Menick, Medical Univ of South Carolina, Charleston, SC D.J. Herr: None. S.E. Aune: None. J.R. Bethard: None. L.E. Ball: None. D.R. Menick: None. 444 Probiotic Administration Mitigates the Detrimental Effects of Myocardial Infarction in Mice John Konhilas, Univ of Arizona, Tucson, AZ J. Konhilas: None. 445 Characterizing the Cardiac Acetylome During Exercise Laura Liu, Massachusetts General Hosp, Boston, MA; Hasmik Keshishian, Broad Inst, Cambridge, MA; Xiaojun Liu, Massachusetts General Hosp, Boston, MA; Tanya Svinkina, Broad Inst, Boston, MA; Carolin Lerchenmüeller, Massachusetts General Hosp, Boston, MA; Glenn C. Rowe, Univ of Alabama at Birmingham, Birmingham, AL; Mun Chun Chan, Massachusetts General Hosp, Boston, MA; Steven A. Carr, Broad Inst, Cambridge, MA; Anthony Rosenzweig, Massachusetts General Hosp, Boston, MA L. Liu: None. H. Keshishian: None. X. Liu: None. T. Svinkina: None. C. Lerchenmüeller: None. G.C. Rowe: None. M.C. Chan: None. S.A. Carr: None. A. Rosenzweig: None. 446 Estrogen and Estrogen Receptor Protect the Female Heart from Ischemia/reperfusion Injury by Increasing the Activity of Mitochondrial p38β and MnSOD Tao Luo, Han Liu, Jin Kyung Kim, Sch of Med, Univ of California Irvine, Irvine, CA T. Luo: None. H. Liu: None. J.K. Kim: None. 447 Essential Role of Stromal Interaction Molecule 1 in Heart Failure Vishal R Mali, Maha Ali, Samuel Haddox, Eastern Virginia Medical Sch, Norfolk, VA; Mohamed Trebak, Penn State Univ, Univ Park, PA, Hershey, PA; Khalid Matrougui, Eastern Virginia Medical Sch, Norfolk, VA V.R. Mali: None. M. Ali: None. S. Haddox: None. M. Trebak: None. K. Matrougui: None. 448 The Loss of Rad GTPase Protects Against Infarction-induced Myocardial Remodeling, Scar Formation, and Decompensatory Dilation Janet R Manning, Bryana M. Levitan, Ayman Haroun, Catherine N. Withers, Prabhakara R. Nagareddy, Jeffrey D. Smith, Univ of Kentucky, Lexington, KY; Christopher M Haggerty, Brandon Fornwalt, Ctr for Health Res, Geisinger Clinic, Danville, PA; Erhe Gao, Temple Univ, Philadelphia, PA; Douglas A. Andres, Jonathan Satin, Univ of Kentucky, Lexington, KY J.R. Manning: None. B.M. Levitan: None. A. Haroun: None. C.N. Withers: None. P.R. Nagareddy: None. J.D. Smith: None. C.M. Haggerty: None. B. Fornwalt: None. E. Gao: None. D.A. Andres: None. J. Satin: None.

This research has received full or partial funding support from the American Heart Association. 449 GRK2-S670A Mice Reveal Cardioprotection Post Ischemia-reperfusion Priscila Y Sato, J Kurt Chuprun, Christopher J Traynham, Anna Maria Lucchese, Ancai Yuan, Erhe Gao, Walter J Koch, Temple Univ Sch of Med, Philadelphia, PA


AB

ST

RA

CT

S

P.Y. Sato: None. J.K. Chuprun: None. C.J. Traynham: None. A. Lucchese: None. A. Yuan: None. E. Gao: None. W.J. Koch: None.

This research has received full or partial funding support from the American Heart Association. 450 Unveiling Human Cardiac Stem Cells Role in Myocardial Ischemia-reperfusion Injury Maria J Sebastião, Margarida Serra, Rute Pereira, Catarina Brito, iBET, Insto de Biologia Experimental e Tecnológica, Oeiras, Portugal; Itziar Palacios, Coretherapix, Tigenix Group, Madrid, Spain; Patrícia Gomes-Alves, Paula M Alves, iBET, Insto de Biologia Experimental e Tecnológica, Oeiras, Portugal M.J.C. Sebastião: None. M. Serra: None. R. Pereira: None. C. Brito: None. I. Palacios: None. P. Gomes-Alves: None. P.M. Alves: None. 451 Leukocyte-expressed β2-adrenergic Receptors Are Essential for Survival Following Acute Myocardial Injury Douglas Tilley, Temple Univ, Philadelphia, PA D. Tilley: None.

This research has received full or partial funding support from the American Heart Association. 452 Effect of Exercise Training on Sleep Quality and Quality of Life in Post Myocardial Infarction Patients Jayati Vohra, Univ Coll of Medical Sciences, Delhi, India; Kushal Madan, Manish Sharma, J.P.S Sawhney, Sir Ganga Ram Hosp, Delhi, India J. Vohra: None. K. Madan: None. M. Sharma: None. J. Sawhney: None. 453 The G Protein-coupled Estrogen Receptor GPER/GPR30 is a Potential Therapeutic Target for Cardiovascular Inflammation Roxana Flores, Victor Nizet, Paul A Insel, Ross Corriden, Univ of California, San Diego, San Diego, CA R. Flores: None. V. Nizet: None. P.A. Insel: None. R. Corriden: None. 454 Protein Phosphatase Pp2a Regulates Hypertrophic Response Through Hdac2 Dephosphorylation in the Heart Hyun-Ki Min, Somy Yoon, Duk-Hwa Kwon, Hyun Kook, Gwang Hyeon Eom, Chonnam Natl Univ Medical Sch, Gwangju, Korea, Republic of H. Min: None. S. Yoon: None. D. Kwon: None. H. Kook: None. G. Eom: None. 455 FGF23-induced Cardiac Hypertrophy is Reversible Alexander Grabner, Saurav Singh, Karla Schramm, Christopher Yanucil, Brian Czaya, Joshua Hare, Christian Faul, Univ of Miami Miller Sch of Med, Miami, FL A. Grabner: None. S. Singh: None. K. Schramm: None. C. Yanucil: None. B. Czaya: None. J. Hare: None. C. Faul: 2. Research Grant; Significant; NIH R01 grant. 3. Other Research Support; Modest; Roche. 3. Other Research Support; Significant; U3 Pharma, Pfizer. 5. Honoraria; Significant; Ultragenyx.


456 Early Doxorubicin Exposure Upregulates P-STAT3 Expression in Adult Murine Model Tanoya L. Harris, Gregory J Aune, UTHSCSA, San Antonio, TX T.L. Harris: None. G.J. Aune: None. 457 Protein Arginine Methyltransferase-1 is Required for Epicardial Epithelial-to-Mesenchymal Transition Olan Jackson-Weaver, Jian Wu, Yongchao Gou, Shihong Shi, Henry Sucov, Jian Xu, Univ of Southern California, Los Angeles, CA O. Jackson-Weaver: None. J. Wu: None. Y. Gou: None. S. Shi: None. H. Sucov: None. J. Xu: None.

This research has received full or partial funding support from the American Heart Association. 458 Novel Interactions with AMP-activated Protein Kinase Identified by Promiscuous Biotin Ligase Assay Yulia Lipovka, John P. Konhilas, Univ of Arizona, Tucson, AZ Y. Lipovka: None. J.P. Konhilas: None. 459 Oxidized CaMKII Causes Atrial Fibrillation Susceptibility in a Diabetic Mouse Model Olurotimi O. Mesubi, Johns Hopkins Univ Sch of Med, Baltimore, MD; Adam G. Rokita, Univ of Iowa, Carver Coll of Med, Iowa City, IA; Biyi Chen, Univ of Iowa Carver Coll of Med, Iowa City, IA; Long-Sheng Song, Univ of Iowa, Carver Coll of Med, Iowa City, IA; Xander H. Wehrens, Baylor Coll of Med, Houston, TX; Mark E. Anderson, Johns Hopkins Univ Sch of Med, Baltimore, MD O.O. Mesubi: None. A.G. Rokita: None. B. Chen: None. L. Song: None. X.H.T. Wehrens: None. M.E. Anderson: 7. Ownership Interest; Significant; Co-founder of Allosteros Therapeutics. 460 β1-Adrenergic Receptor O-glycosylation Regulates Receptor N-terminal Cleavage and Signaling Responses in Cardiomyocytes Misun Park, Columbia Univ, New York, NY; Yang K Xiang, Gopireddy R Reddy, Univ of California at Davis, Davis, CA; Gerd Wallukat, Charité Campus Buch and Max-Delbrück Ctr for Molecular Med, Berlin, Germany; Susan F Steinberg, Columbia Univ, New York, NY M. Park: None. Y.K. Xiang: None. G.R. Reddy: None. G. Wallukat: None. S.F. Steinberg: None. 461 Microrna-126 Overexpression Rescues Impaired Efferocytosis in Diabetes Sahana Suresh Babu, Rajarajan A. Thandavarayan, Darukeshwara Joladarashi, Prince Jeyabal, Shashirekha Krishnamurthy, Houston Methodist Res Inst, Houston, TX; Arvind Bhimaraj, Keith A. Youker, Houston Methodist DeBakey Heart & Vascular Ctr, Houston, TX; Prasanna Krishnamurthy*, Houston Methodist Res Inst, Houston, TX S. Suresh Babu: None. R.A. Thandavarayan: None. D. Joladarashi: None. P. Jeyabal: None. S. Krishnamurthy: None. A. Bhimaraj: None. K.A. Youker: None. P. Krishnamurthy*: None. 462 Activation of Akt2 by Apolipoprotein E Protects ATP-binding Cassette A1 From Degradation Hong Yang, Emmanuel U Okoro, Zhongmao Guo, Meharry Medical Coll, Nashville, TN H. Yang: 2. Research Grant; Significant; NIH SC1HL101431. E.U. Okoro: None. Z. Guo: None.


AB

ST

RA

CT

S

463 Elevated Oxidative Stress and Reduction of Hydrogen Sulfide (H2S) and Nitric Oxide (NO) in HIV Patients: Possible Role in Cardiovascular (CV) Disease Kazi N Islam, Erinn Donnelly, Christopher Parsons, David J Lefer, LSU Health Sciences Ctr, New Orleans, LA K.N. Islam: None. E. Donnelly: None. C. Parsons: None. D.J. Lefer: None. 464 Soluble ST2 is a Novel Marker of Aortic Stiffness and Arteriosclerosis Measured by Invasive Hemodynamic Study Sang-Hyun Kim, Hack-Lyoung Kim, Woo-Hyun Lim, Jae-Bin Seo, Woo-Young Chung, Joo-Hee Zo, Cardiology, Seoul Boramae Hosp, Seoul, Korea, Republic of; Hyang-Lim Lee, Seoul Bukbu Hosp, Seoul, Korea, Republic of; Myung-A Kim, Cardiology, Seoul Boramae Hosp, Seoul, Korea, Republic of S. Kim: None. H. Kim: None. W. Lim: None. J. Seo: None. W. Chung: None. J. Zo: None. H. Lee: None. M. Kim: None. 465 Medical Device Materials and Blood Pressure Alterations in Mice Rafael Jaimes, Children's Natl Medical Ctr, Washington, DC; Meredith Sherman, Adam Swiercz, Narine Muselimyan, Paul Marvar, George Washington Univ, Washington, DC; Nikki Posnack, Children's Natl Medical Ctr, Washington, DC R. Jaimes: None. M. Sherman: None. A. Swiercz: None. N. Muselimyan: None. P. Marvar: None. N. Posnack: None. 466 CUGBP- and ETR 3-like Factor Member 1 Mediates Connexin 43 mRNA Degradation in Dilated Cardiomyopathy Kuei-Ting Chang, Ching-Feng Cheng, Shin-Yi Liu, Guey-Shin Wang, Inst of Biomedical Sciences, Academia Sinica, Taipei, Taiwan K. Chang: None. C. Cheng: None. S. Liu: None. G. Wang: None. 467 Glucose Promotes M2-related Transcriptional Reprogramming of Resident Cardiac Macrophages in Response to Hypothermic Ischemic Arrest and Reperfusion Ahmed Bux, The Univ of Mississippi Medical Ctr, Jackson, MS; Hernan Vasquez, Heinrich Taegtmeyer, The Univ of Texas Medical Sch at Houston, Houston, TX; Romain Harmancey, The Univ of Mississippi Medical Ctr, Jackson, MS A. Bux: None. H. Vasquez: None. H. Taegtmeyer: None. R. Harmancey: None.

468 Identification of a New Component of the Nav1.5 Complex: αB-crystallin Interacts with Nav1.5 and Regulates Ubiquitination and Internalization of Cell Surface Nav1.5 Yuan Huang, Zhijie Wang, Yinan Liu, Key Lab of Molecular Biophysics of the Ministry of Education, Huazhong Univ of Science and Technology, Wuhan, China; Qiuyun Chen, Qing k. Wang, Dept of Molecular Cardiology, Lerner Res Inst, Cleveland Clinic, Cleveland, OH Y. Huang: None. Z. Wang: None. Y. Liu: None. Q. Chen: None. Q. Wang: None. 469 Gene Expression Profiling Reveals Genes and Pathways Involved in the Cardiac Protection of Valosin-containing Protein in the Heart Shaunrick Stoll, Xin Chen, Charles Wang, Hongyu Qiu, Loma Linda Univ, Loma Linda, CA S. Stoll: None. X. Chen: None. C. Wang: None. H. Qiu: None. 470 Computational Identification of NKX2-5 Binding Sites and Downstream Gene Targets Using Transcription Factor Motif and Human Heart-specific Experimental Data Nicholas Tan, Mayo Clinic, Rochester, MN; Mina K Chung, Jonathan D Smith, David R Van Wagoner, John Barnard, Cleveland Clinic, Cleveland, OH N. Tan: 2. Research Grant; Modest; AHA Scholarship in Cardiovascular Disease. M.K. Chung: None. J.D. Smith: None. D.R. Van Wagoner: None. J. Barnard: None.



Author Index A

UT

HO

R IN

DE

X

Abassi, Yama ............................ 234, 384Abdellatif, Maha ................................ 138Abdullah, Chowdhury S. ................... 273Abell, Lauren .................................... 401Abend, Alon ..................................... 136Abesser, Marco ..................................62lAbu Al-Rub, Ejlal ........................... 27, 36Adler, Eric ................................. 109, 224Afrin, Rejina ...................................... 256Aghdami, Nasser .............................. 369Aguero, Jaume ................................. 229Aguilar, Jose S. ................................. 126Ahmad, Firdos ...................... 69, 75, 280Ahn, Youngkeun ....................... 241, 299Ahsan, Muhammad ............. 46, 227, 228Ai, Xiaojie .................................. 122, 134Ajijola, Olujimi A. ............................... 314Akar, Fadi G. ............................. 229, 441Akasaki, Yuichi .................................... 42Akerman, Adam W. .......................... 135Akhter, Muhammad A. ...................... 367Alam, Shafiul ............................ 222, 281Alcaide, Pilar ..................................... 408Alencar, Allan K. Nogueira. ................ 267Alencar, Allan K. N. ........................... 410Alexander, Jonathan Steven ............. 406Al-Habeeb, Walid .............................. 390Ali, Anwar ......................................... 367Ali, Maha .......................................... 447Alimohamadi, Sahar ........................... 35Aljishi, Mohammed ................... 303, 430Alleman, Rick J. ................................ 101Allen, Mitchell E. ............................... 101Allen, Sean ....................................... 316Alloush, Jenna .................................... 86Altamimi, Tariq R. .............................. 282Alvarez, Roberto J. ........................... 353Alves, Paula M. ................................. 450Alyacoub, Nadya .............................. 390Alzahrani, Talal .................................. 303Ambardekar, Amrut .................... 57, 382Thandavarayan, Rajarajan A. ............. 200An, Xi-Zhou ...................................... 434Anderson, Corey L. ........................... 394Anderson, Jenna .............................. 380Anderson, Mark E. .................... 402, 459Andrades, Michael .............. 70, 268, 318Andres, Douglas A. ........................... 448Angelini, Gianni ................................... 52Appikatla, Prasanthi ............................ 86Araujo, Josenildo S. C. ..................... 410Arce-Fonseca, Minerva ....... 47, 230, 383Arias-Loza, Paula-Anahi ..................... 62Armstrong, Chris ................................ 51Arnone, Baron .......................... 217, 376Arokiaraj, Mark ........................... 20, 201Aronovitz, Mark ................ 251, 408, 424Aroonsakool, Nakon ........................... 98Arrieta, Adrian ................................... 291Arumugam, Somasundaram .... 125, 256Asfour, Huda .................................... 430Ashangari, Chandralekha ... 46, 227, 228Ashton-Prolla, Patrícia ...................... 318Auger-Messier, Mannix ..................... 260Aune, Greg ....................................... 425Aune, Gregory J. .............................. 456Aune, Sverre E. ................................. 443Avalos, Alan ...................................... 126Avelar, Abigail ..................................... 59Avery, Ryan ...................................... 205Awad, Salma .................................... 390Ayabe, Kengo ................................... 295Azad, Abul ........................................ 427Azevedo, Paula S. .............................. 87Baba, Osamu ................................... 277Babaeva, Ekaterina ........................... 308

Babayeva, Oguljahan ........................ 283Baharvand, Hossein ......................... 369Bahl, Joseph J. ................................ 360Bai, Xiaowen ..................................... 439Bailey, Brandi .................................... 211Balakrishnan, Anju ............................ 252Balderas, Enrique ............................. 137Baldwin, Kristin ................................. 288Balkan, Wayne ........................ 56, 66, 74Ball, Lauren E. .................................. 443Bando, Yasuko K. ............................. 313Barakati, Neusha .............................. 442Barefield, David Y. ............................. 391Barnard, John .......................... 244, 470Barreiro, Eliezer J. ............................. 410Barton, Dane W. ................................... 3Baskin, Kedryn K. ............................. 317Bassel-Duby, Rhonda ....................... 317Basu, Ratnadeep ........................ 80, 427Batkai, Sandor .................................... 72Bauer, Ralf .......................................... 72Bauersachs, Johann ........................... 72Baumgartner, Robert A. .................... 251Bayoumi, Ahmed S. .......................... 112Beach, Thomas ................................ 380Beck, Eric X. ....................................... 86Bedrossian, Nora .............................. 402Beigi, Farideh ..................................... 29Beiner, Nelli ....................................... 270Belaygorod, Larisa ............................ 312Bender, Ingrid ............................. 23, 218Benedict, Cindy ............ 40, 99, 220, 294Benedict, Cynthia ....................... 24, 298Bergeron, Alexandre ........................... 88Bernstein, Daniel .............................. 431Bernstein, Sanford I. ......................... 419Bernt, Alexander ............................... 393Berretta, Remus M. .......... 2, 53, 84, 364Bethard, Jennifer R. .......................... 443Bezold Kooiker, Kristina .............. 85, 431Bezzeridis, Vassilios J. ...................... 422Bhandary, Bidur .......................... 95, 269Bhattacharya, Sayak ........................... 86Bhimaraj, Arvind ....................... 372, 461Bhuiyan, Shenuarin ............ 95, 222, 269, .................................................. 281, 406Bielawski, Jacek ................................. 87Bigham, Grace ......................... 209, 351Billia, Filio .......................................... 250Biolo, Andreia ..................... 70, 268, 318Bitsch, Nicole ..................................... 81Blackwood, Erik A. ................... 291, 292Blanton, Robert M. ................... 251, 424Blaxall, Burns C. ....... 222, 264, 409, 428Blinova, Ksenia ......................... 234, 384Bodmer, Rolf .................................... 419Boerries, Melanie .............................. 270Boivin, Benoit ..................................... 88Bolli, Roberto .............................. 34, 354Bonegio, Ramon G. .......................... 436Booth, Brandon ................................ 298Bopassa, Jean C. ............................. 115Borghetti, Giulia .............. 21, 53, 84, 386Boriboun, Chan ................ 217, 221, 376Bosnjak, Zeliko ................................. 439Böttner, Martina ................................ 393Bradner, James E. ............................ 417Brand, Cameron S. ........................... 123Braun, Alyssa N. ............................... 437Brink, Marijke .................................... 270Brito, Catarina .................................. 450Brittian, Kenneth R. ............................ 25Brody, Matthew J. ............................ 373Brohawn, Philip Z. ............................ 209Brooks, Heddwen L. ........................... 94Broskova, Zuzana ............................. 293

Broughton, Kathleen ......................... 350Brown, David A. ............................... 101Brown, Jonathan D. .......................... 417Bruns, Danielle R. ............................. 249Bu, Lei ................................................ 22Bugg, Darrian N. ............................... 382Bugyei-Twum, Antoinette .................. 250Bull, Mathew .................................... 398Bunch, Thomas A. ............................ 387Burciu, Camelia ................................ 380Burke, Michael A. ............................. 417Burridge, Paul W. .............................. 289Busch, Hauke ................................... 270Buttrick, Peter M. ............................. 249Bux, Ahmed ..................................... 467Cadag, Eithon .................................... 51Cai, Chen-Leng .................................. 22Cai, Lu ...................................... 279, 385Cai, Ren Z. ......................................... 74Cai, Renzhi ......................................... 56Cai, Weibin ......................................... 22Calamaras, Timothy D. ..................... 251Calvert, John ............................ 233, 438Cameron, Joshua ............................. 126Cammarato, Anthony ....................... 419Campbell, Barry ................................ 262Cannavo, Alessandro ................ 113, 290Cantalupo, Anna ................................. 87Cao, Yuan ........................................ 246Caputo, Massimo ............................... 52Carbajal-Hernández, Ana C. ............... 47Carr, Steven A. ................................. 445Carrillo-Sánchez, Silvia ....... 47, 230, 383Carullo, Pierluigi ................................ 320Caspi, Lilac ....................................... 136Cassidy, Liam ................................... 393Catar, Rusan ..................................... 270Cattini, Peter A. ................................ 374Chahbazian, Tigran ........................... 430Chamuleau, Steven A. J. .................... 55Chan, Dulciana ................................. 234Chan, Mun C. ................................... 445Chandra, Mini ................................... 406Chandrasekhar, Sanjay ....................... 61Chang, Jiang .................................... 114Chang, Karen H. ............................... 120Chang, Kuei-Ting ............................. 466Chao, Dongman ............................... 226Chapski, Douglas J. ................. 137, 319Charles, Christopher J. ..................... 265Chatterjee, Arunachal ....................... 128Chau, Sarah ..................................... 248Chaudhary, Rakesh ............................ 36Chen, Biyi ................................. 237, 459Chen, Haodong ................................ 365Chen, Hong ...................................... 304Chen, Hou-Zao ................................. 434Chen, Huei-Sheng Vincent ............... 110Chen, Jau-Nian ................................ 247Chen, Jing ........................................ 279Chen, Jing-Hai ................................... 78Chen, Jinghai ..................................... 91Chen, Jiqiu ......................................... 22Chen, Jun ......................................... 279Chen, Kai ......................................... 263Chen, Ling ........................................ 351Chen, Qiuyun ................................... 468Chen, Rong ...................................... 237Chen, Rou ........................................ 235Chen, Wenliang ................................ 305Chen, Xi ............................................ 235Chen, Xiao-Feng ............................... 434Chen, Xin .......................................... 469Chen, Xiongwen ......... 84, 122, 134, 296Chen, Yei-Tsung ............................... 414Chen, Yi ..................................... 44, 238


AU

TH

OR

IND

EX

Chen, Yingjie .................................... 399Chen, Zhidan .................................... 276Chen, Zhongjian ................................. 40Chen, Zhongming ............................... 23Cheng, Ching-Feng .................. 418, 466Cheng, Wen C. ................................. 208Cheng, Yuan-Yuan ............................ 202Cheng, Zhongjian ....................... 24, 134Chi, Neil ............................................ 224Chi, Neil C. ....................................... 109Chin, Lih-Shen .................................. 233Chinison, Jessica .............................. 126Chinyere, Ike ............................... 205, 71Chiuchiolo, Maria J. .......................... 363Cho, Hana ........................................ 203Cho, Hyun-Jai .................................... 65Choi, Yong Seon ............................... 401Chonchol, Michel .............................. 382Chotani, Maqsood A. ........................ 124Chour, Tony ...................................... 365Chow, Moses ................................... 126Christen, Lynn .................................. 393Chung, Charles S. ............................ 236Chung, Mina K. ................................ 470Chung, Woo-Young .......................... 464Chuprun, J K. ................................... 449Chuprun, J. Kurt ............................... 278Cimini, Maria ..................................... 294Civin, Curt I ....................................... 208Clausell, Nadine ........................ 268, 318Cohen, Carolina R. ........................... 318Coller, John ...................................... 357Colson, Brett A. ................................ 387Condorelli, Gianluigi .......................... 320Connelly, Kim A. ............................... 250Conner, David A. .............................. 417Constantopoulos, Eleni ....................... 94Contreras, Jorge ............................... 255Cooney, Austin ................................... 33Coronado, Michael ........................... 431Corriden, Ross ................................. 453Cortez, Melissa Q. ............................ 223Corvera, Silvia ................................... 397Coulis, Gerald ..................................... 88Cox, James .......................................... 3Craig, Roger ..................................... 389Crombie, Kathryn ............................... 82Crosbie-Watson, Rachelle H. .............. 79Crystal, Ronald G. ............................ 363Curuja, Fernanda ........................ 70, 268Czaya, Brian ..................................... 455da Costa Martins, Paula A. ................. 26Da Cunha, Valdeci .................... 252, 262Dai, Yuan .......................................... 114Dajee, Maya ..................................... 252D’Amico, Maria Loreta .............. 113, 290Danilo, Christiane A. ........................... 94Dassanayaka, Sujith ........................... 25Datla, Srinivasa Raju ......................... 351Daugherty, Sherry ............................. 205Davatzikos, Christos ........................... 28Davis, Michael E. .............. 207, 212, 219Davis, Roger J. ................................. 251Deacon, Dekker C. ........................... 109DeAguero, Joshua ............................ 352DeFranco, Alessandra ........................ 96DeLeon, Susan ................................. 317Delfín, Dawn A. ................................. 352Delgobbo, Mateus S. ........................ 410Delisle, Brian T. ................................. 394Dellefave-Castillo, Lisa ...................... 391DeMartino, Angelica M. ...................... 25Dengjel, Joern .................................. 270Denney Jr., Thomas .......................... 366Dent, Lemuel .................................... 378Deo, Rahul C. ..................................... 64

DeQuevedo, Joao L. ......................... 125Deranek, Andrea ................................. 58DesAulniers, Jessica ........................... 80Deschênes, Isabelle .......................... 259de Tantillo, Lila .................................. 377de Weger, Roel ................................... 26De Windt, Leon J. ............................... 26Dharma, Lindarto ................................ 32Dhingra, Sanjiv ............................. 27, 36Diakos, Nikolaos ............................... 412Difede, Darcy .................................... 355Ding, Guanghong ............................. 226Ding, Jian ........................................... 91Ding, Wen ........................................ 266Ding, Yichen ....................................... 68Dirkx, Ellen ......................................... 26Dobashi, Izumi .................................... 30Doevendans, Pieter A. ........................ 55Dong, Nianguo ................................... 43Donnarumma, Erminia ...................... 132Donnelly, Erinn .......................... 132, 463Doosti, Mahmood ............................. 369Doroudgar, Shirin ...................... 211, 291Douglas, Diana ................................... 82Dragun, Duska ................................. 270Drakos, Stavros ................................ 412Drakos, Stavros G. ............................. 91Drosatos, Konstantinos .................... 301Drum, Benjamin ................................ 238Du, Fanfan ........................................ 316Dudley, Samuel C. ............................ 285Dudley, SC Jr ................................... 243Dulce, Raul A. ......................... 56, 66, 74Dupont, Kenneth M. ......................... 219Duran, Jason ...................................... 28Dworatzek, Elke .................................. 89Eding, Joep E. .................................... 55Edwards, Stacie ............................... 102Eghbali, Mansoureh .......... 253, 321, 442el Azzouzi, Hamid ............................... 26Ellis, Dallas ....................................... 283Ellmers, Leigh J. ............................... 265Elrod, John W. .................................. 435Emanueli, Costanza ............................ 52Emelyanova, Larisa ............... 96, 97, 102Endo, Jin .......................................... 254Engler, Adam ............ 109, 288, 419, 426Enso, Jin .......................................... 287Entman, Mark L. ............................... 129Eom, Gwang Hyeon ................. 241, 454Escalante-Alcalde, Diana .................. 406Fajardo, Giovanni .............................. 431Fan, Dong .......................................... 80Fandrich, Robert R. .......................... 374Fang, Longhou ................................. 307Farah, Hassan-Galaydh ...................... 58Farhan, Maikel .................................. 427Farid, Talha ......................................... 34Farid, Talha A. ................................... 354Fass, Ofer ........................................... 58Faul, Christian ................................... 455Feng, Yansheng ................................ 115Ferguson, William ............................. 288Fernandez, Vanessa ........................... 76Fertouk, Michal ................................. 136Ficker, Eckhard ................................. 259Fischer, Matthew A. ............................ 50Fish, Kenneth R. ............................... 229Fishbein, Michael .............................. 314Fitzgibbons, Timothy ........................ 397Fliegner, Daniela ................................. 89Florea, Victoria .................................. 355Flores, Elsa ......................................... 33Flores, Roxana ................................. 453Fomovsky, Gregory M. ...................... 108Force, Thomas L. ................. 69, 75, 280

Fornwalt, Brandon ............................ 448Fox, Jonathan .................................. 406Fox, Philip R. ...................................... 53Fracasso, Bianca ........................ 70, 268Fraga, Aline G. .................................. 267Fraidenraich, Diego ........................... 255Francis, Sharon C. ............................ 283Franco, Daniel .................................. 380Frank, Derk ....................................... 393Franklin, Adam N. ............................. 309Franklin, Sarah .............................. 3, 412Frey, Norbert ..................................... 393Fu, Zongming ................................... 419Fuhrmann, Alexander ....................... 419Fukuda, Keiichi ......................... 254, 287Fukushima, Arata .............................. 282Funayama, Naohiro .......................... 379Furuhata, Takaaki ............................. 105Gaestel, Matthias ................................ 72Galjart, Niels J. ................................. 137Gambino, Giuseppina ............... 113, 290Gao, Chen ................................ 240, 247Gao, Erhe .................. 40, 220, 278, 294, .......................................... 301, 448, 449Gao, Ling ........................................... 41Gao, Qun ......................................... 119Gao, Su ............................................ 282Garcia, Andres .................................. 210Garcia, Martha Iveth ......................... 388Garcia-Menendez, Lorena ................ 401Garikipati, Venkata N. Srikanth. ......... 220Garikipati, Venkata NS ................. 24, 40, .................................................... 99, 294Garry, Daniel J. ......................... 359, 370Garry, Mary G. .......................... 359, 370Gault, Emily ...................................... 224Gauthier-Fisher, Andree .............. 31, 358George, John ................................... 128Geurink, Inka .................................... 393Ghafghazi, Shahab ............................. 25Ghazizadeh, Zaniar ........................... 369Giacca, Mauro .................................... 26Gibson, Brian W. ................................ 37Gilbert, Merle .................................... 238Giordano, Frank J. .............................. 87Giridharan, Vijayasree V. ............ 125, 256Glembotski, Christopher ... 211, 291, 292Gobin, Andrea .................................... 29Goichberg, Polina ............................. 386Goldberg, Ira J. ................................ 301Goldman, Steven .......... 48, 71, 205, 360Gomes-Alves, Patrícia ...................... 450Gong, Hui ......................................... 276Gong, Wuming ................................. 370Gonzalez, Eileen R. ............................. 45Gonzalez, J. Patrick .......................... 255Gonzalez-Guarda, Rosa M. .............. 377Gorham, Joshua M. .......................... 417Goto, Shinichi ................................... 295Goto, Shinya .................................... 295Gottlieb, Roberta .............................. 431Gou, Yongchao ........................ 130, 457Govindan, Suresh ............................. 389Grabner, Alexander ........................... 455Gradinaru, Irina ................................. 308Grahammer, Florian .......................... 270Granzier, Henk L. ........................ 76, 398Greco, Carolina ................................ 320Green, Jonette M. ............................. 222Green, Tom D. .................................. 101Greene, Steven ................................. 353Groban, Leanne ................................ 267Gross, Polina ........................ 21, 28, 296Grove, Lisa M. .................................. 423Gruia, Flaviu ...................................... 209Grund, Andrea .................................... 72

Author Index (continued)



AU

TH

OR

IND

EX

Gu, Haiwei ........................................ 401Gu, Junlian ....................................... 279Gude, Natalie ................................... 350Guergen, Dennis B. .......................... 270Gulick, James ................................... 269Guo, Ang .......................................... 237Guo, Haidong ................................... 246Guo, Xaioyun .............................. 44, 238Guo, Yin ........................................... 351Guo, Zhongmao ....................... 378, 462Gupta, Abhishek ............................... 282Gupta, Anu ....................................... 102Gupta, Mahesh ................................... 78Gupta, Manveen ............................... 272Gupta, Ramesh C. ............................ 432Gupta, Sudhiranjan ................... 271, 420Gupte, Anisha A. .............................. 284Gururaja Rao, Shubha ........................ 61Gushchina, Liubov .............................. 86Gustafsson, Åsa B. ............ 45, 103, 223, .......................................................... 375Ha, Tuanzhu ............................. 117, 214Haase, Hannelore ............................. 239Haddox, Samuel ............................... 447Haggerty, Christopher M. .................. 448Hahn, Andreas ............................. 1, 440Hajjar, Roger J. ................... 22, 206, 229Hakuno, Daihiko ............................... 277Haldar, Saptarsi M. ........................... 417Hambly, Brett D. ................................. 60Hamilton, Dale J. .............................. 284Hammerling, Babette C. ................... 223Han, Jung-Kyu ................................... 65Han, Shuling ............................. 356, 376Han, Yaling ....................................... 361Hanick, Andrea ................................. 244Hao, De-Long ................................... 434Hao, Jijun ......................................... 126Happe, Cassandra ........................... 109Hardie, D. Grahame .......................... 243Hardin II, Darrell .................................. 74Hare, Joshua M. .......................... 56, 66, ........................................... 74, 355, 455Harima, Meilei ................................... 256Harmancey, Romain ......................... 467Haroun, Ayman ................................. 448Harper, Shavonn C. .......................... 116Harris, Samantha P. ............................ 85Harris, Tanoya L. ............................... 456Harrison, Michael R. ......................... 245Hartmann, Svenja ............................... 90Hasegawa, Koji ................................ 277Hasenfuss, Gerd ............................... 400Hashem, Sherin ................................ 224Hatakeyama, Shigetsugu .................. 105Hays, Tristen T. ................................. 407He, Congcong .................................. 376He, Minzhen ............................. 138, 261Heallen, Todd ................................... 396Heineke, Joerg ................................... 72Heller Brown, Joan ........................... 123Herr, Daniel J. ................................... 443Heuser, Richard R. ............................ 297Heymans, Stephane ........................... 81Higuchi, Koji ....................................... 42Hofer, Ira ............................................. 50Holeman, Teryn ................................ 257Holmstrom, Alexandra ...................... 365Holmuhamedov, Alisher ...................... 96Holmuhamedov, Ekhson ............... 96, 97Hong, Xuening .................................. 262Honnorat, Nicolas ............................... 28Horie, Takahiro .................................. 277Horikoshi, Yuichi ............................... 439Hotta, Daisuke .................................. 379Hou, Luqia ........................................ 357

Hou, Ning ......................................... 305Houser, Steven R. .............. 2, 21, 28, 53,.................... 84, 116, 134, 296, 298, 364Howard-Quijano, Kimberly .................. 50Howatt, Deborah A. .......................... 252Hsiai, Tzung ........................................ 68Hsieh, Ya-Ting .................................. 418Hsu, Shu-Chan ................................. 361Hu, Dong-Qing ................................. 431Hu, Jun .................................... 229, 441Hu, Xin-Yang ...................................... 78Hu, Yuanping ............................ 117, 214Hua, Xiang ................................ 122, 134Huang, Chin-hu ................................ 262Huang, Chunkai ................................ 237Huang, Guo-Ying ................................ 22Huang, Hao ...................................... 392Huang, Ngan .............................. 38, 357Huang, Yan ......................................... 87Huang, Ying ...................................... 126Huang, Yuan ..................................... 468Huang, Zhanpeng ............................... 91Huber, Tobias B. ............................... 270Huby, Anne-Cecile .............................. 29Hull, Robert W. ................................. 140Hunt, Gregory N. ................................ 25Hutchinson, Kirk ............................... 398Ibanez, Borja ............................ 113, 290Ibetti, Jessica ................................... 294Ichihara, Atsuhiro .............................. 254Ide, Yuya .......................................... 277Ikeda, Shiro ...................................... 274Ikeda, Shohei ..................................... 73Ikeda, Yoshiyuki ............................ 42, 83Ikonomidis, John S. .......... 135, 309, 429Ilham, Hariaji ....................................... 32Ilves, Kelli .......................................... 353Inazumi, Hideaki ............................... 405Infanto, Aniello M. ............................. 140Insel, Paul ................................... 98, 453Inui, Akitoshi ....................................... 30Iqbal, Farwah .............................. 31, 358Ishikawa, Kiotake .............................. 229Islam, Kazi N. ........................... 132, 463Isobe, Mitsuaki ................................. 403Ito, Kentaro ....................................... 254Ito, Yusuke ....................................... 403Ivey, Malina J. ..................................... 92Iwabayashi, Masaaki ........................... 42Jack, Godly ...................................... 351Jackson-Weaver, Olan .............. 130, 457Jaffre, Fabrice ............................... 1, 440Jahangir, Arshad ................... 96, 97, 102Jaimes, Rafael .................................. 465James, Jeanne ................................. 222Jansen of Lorkeers, Sanne J. ............. 55Janssen, Paul M. L. ............................ 86January, Craig T. ............................... 394Jarry, Hubertus ................................. 400Jatho, Aline ........................................ 90Jayasundar, Jayant James .................. 58Jeong, Dongtak .................................. 22Jeong, Mark ....................................... 57Jeong, Myong-Ho ............................ 203Jeremy, Richmond .............................. 60Jeyabal, Prince ......... 200, 204, 372, 461Jia, Jianguo ...................................... 276Jiang, Xuan ...................................... 416Jiang, Xue-jun ................................... 216Jin, J.P. ............................................. 257Jin, Zhuqiu ........................................ 273Johannesen, Lars ..................... 234, 384Johns, Douglas G. ............................ 252Johnson, Jaslyn ............................ 2, 364Jokerst, Clint .................................... 205Joladarashi, Darukeshwara .............. 200,

.................................. 204, 294, 372, 461Jones, Jeffrey A. ............... 135, 309, 429Jones, Steven P. ................................. 25Jordan, Maria C. ................................. 79Juneman, Elizabeth ..................... 48, 71, ................................................. 205, 360Jung, Gwanghyun ............................ 431Jung, Saet-byel ................................ 433Jungmann, Andreas ........................... 72Jung-Woong Kim, Joseph .................. 38Kabir, Mohammad Enamul ................ 115Kaelber, Jason T. .............................. 129Kakkar, Rahul ................................... 382Kalbfleisch, John ...................... 117, 214Kamal, Fadia A. ................................ 428Kameshima, Satoshi ......................... 274Kaminsky, Stephen M. ...................... 363Kanashiro-Takeuchi, Rosemeire ... 56, 74Kang, Chifei ...................................... 255Kang, Jong-Sun ............................... 203Kang, Ju Hee ................................... 299Kang, Kyungjin ................................. 203Kang, Wan Seok ............................... 299Kanisicak, Onur ................ 362, 373, 421Kao, Race ................................ 117, 214Kapiloff, Michael ....................... 127, 306Karakikes, Ioannis ............................. 289Karamanova, Nina ............................ 380Karanthasis, Sotirios ......................... 209Kararigas, Georgios .......................... 400Karas, Richard H. ............................. 251Karbassi, Elaheh ............................... 319Karch, Jason .................... 222, 373, 421Kardami, Elissavet ............................ 374Karimpour-Fard, Anis ........................ 416Karsenty, Gerard ................................. 88Karuppagounder, Vengadeshprabhu ....... .................................................. 125, 256Kassiri, Zamaneh ........................ 80, 427Katayama, Takashi ............................ 105Katus, Hugo A. ................................... 72Kaushal, Sunjay ................ 208, 209, 351Kaushik, Gaurav ....................... 419, 426Kawamura, Youth ............................. 295Kawase, Haruya ............................... 313Kehat, Izhak ..................................... 136Kekic, Murat ....................................... 60Kelly, Daniel P. ................................... 110Kenigsberg, Shlomit ......................... 358Kennan, Richard ............................... 262Keshishian, Hasmik .......................... 445Kevil, Christopher ............................. 406Khalafalla, Farid ................................ 353Khalil, Hadi ............................... 275, 421Khan, Abdur R. ........................... 34, 354Khan, Aisha ...................................... 355Khan, Irfan ........................................ 367Khan, Mohsin .................. 2, 24, 40, 139, .................................. 200, 220, 298, 364Khieu, Tiffany .................................... 350Kilic, Ahmet ........................................ 86Kim, Bin Na ...................................... 205Kim, Cuk-Seong ............................... 433Kim, Hack-Lyoung ............................ 464Kim, Hyo-Soo ..................................... 65Kim, Hyun-Ji ..................................... 203Kim, Il-man ....................... 112, 293, 310Kim, Jin K. ........................................ 446Kim, Jong ........................................... 39Kim, Joseph ..................................... 357Kim, Kevin .......................................... 51Kim, Maengjo ................................... 401Kim, Myung-A .................................. 464Kim, Samuel ..................................... 205Kim, Sang-Hyun ............................... 464Kim, Yong Sook ........................ 241, 299


AU

TH

OR

IND

EX

Kimball, Todd .............................. 50, 137Kimura, Takeshi ........................ 277, 405Kingsbury, Tami ................................ 208Kinoshita, Hideyuki ........................... 405Kinugawa, Shintarou ......................... 105Kirshenbaum, Lorrie A. ..................... 374Kishore, Raj ........... 24, 40, 99, 139, 200, .......................... 204, 220, 294, 298, 372Kita, Toru .......................................... 277Kluge, Annika ..................................... 93Knapp, Maura ............................ 63, 392Kobayashi, Eiji .................................... 30Koch, Walter J. ........ 113, 106, 278, 290, .................................. 294, 298, 301, 449Koh, Won-Joon ................................ 441Kohut, Andrew R. ............................... 61Koleini, Navid .................................... 374Koller, Sarah ....................................... 28Kolwicz, Stephen .............................. 437Kolwicz, Jr., Stephen C ..................... 104Konhilas, John .................................. 444Konhilas, John P. ........................ 94, 458Konishi, Takao .................................. 379Konishi, Tetsuya ................................ 125Kontaridis, Maria ........................... 1, 440Kook, Hyun .............................. 241, 454Korf-Klingebiel, Mortimer .................... 72Kouwenberg, Lisanne E. ..................... 55Koyama, Satoshi .............................. 277Koyano-Nakagawa, Naoko ............... 370Kraft, Kelsey ..................................... 102Kralik, Stephen F. .............................. 235Kren, Stefan M. ................................ 359Krenz, Maike ...................................... 82Krishnamurthy, Prasanna ........... 99, 125,.......................... 200, 204, 294, 372, 461Krishnamurthy, Shashirekha ............. 372, .......................................................... 461Ku, Hui-Chen .................................... 418Kubli, Dieter A. .................................... 45Kubo, Hajime ................................ 2, 364Kulandavelu, Shathiyah ....................... 66Kulkarni, Rajan ................................... 68Kumar, Aditya ................................... 288Kunderfranco, Paolo ......................... 320Kunhi, Mohmad ................................ 390Kusch, Angelika ................................ 270Kuster, Diederik W. D. ....................... 389Kuwabara, Yasuhide ......................... 277Kuwahara, Koichiro .......................... 405K Verma, Suresh ............................... 200Kwok, Wai-Meng .............................. 439Kwon, Duk-Hwa ....................... 241, 454Kwon, Yoo-Wook ............................... 65Ky, Bonnie ........................................ 225Kyselovic, Jan .................................... 91Labbe, David ...................................... 88LaCanna, Ryan ................................... 67Lai, Liangxue .................................... 215Lakatta, Edward G. ........................... 419Lal, Hind ............................... 69, 75, 280Lampert, Mark A. ................................ 45Lancaster, Jordan ......................... 48, 71Lancaster, Jordan J. ................. 205, 360Lancaster, Laryenth D. ...................... 205Lane, Angela M. ............................... 251Langenbacher, Adam ....................... 247Larson, Brandon ............................... 205Laurita, Kenneth R. ........................... 259Leach, John ..................................... 396Lecomte, Julie .................................... 81Lee, Candace ................................... 258Lee, Choon-Soo ................................. 65Lee, Hyang-Lim ................................ 464Lee, Jin-Woo ...................................... 65Lee, Kyounghwan ............................. 389

Lee, Leonard .................................... 361Lee, Samuel ..................................... 108Leem, Young-Eun ............................. 203Lefer, David J. ..................... 24, 132, 463Lehman, Sarah J. ............................. 402Leinwand, Leslie A. ........................... 382Lemstra, Mark .................................. 231Leon, Leonardo J. .................... 103, 375Leone, Teresa C. .............................. 110Lepak, Victoria C. ............................. 387Lerchenmüeller, Carolin ............. 442, 445Levit, Rebecca .................................. 210Levitan, Bryana M. ............................ 448Lew, Kar Sheng ................................ 265Li, Chuanfu ............................... 117, 214Li, Faqian .................................. 305, 311Li, Hong ........................................... 354Li, Huadong ........................................ 43Li, Jiang ............................................ 213Li, Jin .................................................. 68Li, Jing ........................................ 238, 44Li, Jingbo ......................................... 302Li, Jingyuan ...................................... 442Li, Jinliang ................................ 127, 306Li, Lei ......................................... 238, 44Li, Li ......................................... 271, 420Li, Lian .............................................. 233Li, Ren-Ke .......................................... 31Li, Shaohua ...................................... 361Li, Shumin ........................................ 284Li, Tao .............................................. 104Li, Xiao-yan ....................................... 216Li, Xiaofeng ....................................... 306Li, Xiaomo ........................................ 316Li, Yang ............................................ 276Li, Ying ............................................. 122Li, Ze-yong ....................................... 216Li, Zhenping ..................................... 286Liang, Yaxuan ................................... 206Liao, James K ............................ 392, 63Librach, Clifford .......................... 31, 358Liccardo, Daniela ................ 67, 113, 290Lien, Ching-Ling ............................... 245Lieser, Sarah L. ................................. 309Lim, Hadyanto .................................... 32Lim, Woo-Hyun ................................ 464Lima, Lidia M. ................................... 410Lin, Bo ................................................ 39Lin, Chen .......................................... 235Lin, Heng .......................................... 418Lin, Xi ............................................... 114Lin, Yin ............................................... 57Lin, Zhiqiang ............................... 91, 246Lipovka, Yulia ............................. 94, 458Liu, Chun .................................. 289, 365Liu, Depei ......................................... 434Liu, Haiyan ....................................... 259Liu, Han ............................................ 446Liu, Hong .......................................... 243Liu, Jiandong ...................................... 35Liu, Jie .............................................. 361Liu, Laura ......................................... 445Liu, Lixin ........................................... 119Liu, Man ........................................... 285Liu, Qihai .......................................... 215Liu, Qinghang ............................. 44, 238Liu, Quan .......................................... 279Liu, Shin-Yi ....................................... 466Liu, Xiaohong .................................... 399Liu, Xiaojun ....................................... 445Liu, Yinan ......................................... 468Liu, Yugang ...................................... 316Long, Bethany W. ............................... 25Lopaschuk, Gary D. .......................... 282Lopes, Amanda .................................. 70Lorenz, John N. ................................ 222

Lorenzo, Annarita D. ........................... 87Lo Sardo, Valentina ........................... 288Losordo, Douglas W. ........................ 206Lozano-Camacho, Mónica ................. 47Lu, Fei .............................................. 247Lu, Hong .......................................... 252Lu, TungYing ...................................... 39Lu, Yaxin ............................................. 60Lucchese, Anna Maria ...................... 449Luckey, Stephen ....................... 238, 395Luo, Jiandong .................................. 305Luo, Tao ........................................... 446Luo, Yu-Xuan .................................... 434Luongo, Timothy S. .......................... 435Lusis, Aldons J. ................................ 133Lutz, Susanne .................................... 90Lynch, Thomas L. ............................. 389Lynn, Melissa .............................. 58, 257Ma, Ben ........................................... 407Ma, Li ............................................... 119MA, Peter X. ..................................... 215Maafi, Foued .................................... 258MacCannell, Keith .............................. 59Madan, Kushal ................................. 452Madungwe, Ngonidzashe Benson .... 115Madwed, Jeffrey B. ..................... 53, 262Maejima, Yasuhiro ............................. 403Mahaffey, Jennifer ............................... 57Mahajan, Aman .................................. 50Mahmoodzadeh, Shokoufeh ....... 89, 239Mai, Yunpei ....................................... 305Makaju, Aman .................................. 412Makarewich, Catherine A. ................. 317Maleski, Danielle ............................... 259Mali, Vishal R. ................................... 447Maliken, Bryan .......................... 362, 421Manning, Janet R. ............................ 448Mao, Renfang ................................... 307Mao, Yun .......................................... 363Margulies, Kenneth B. ...................... 225Maria, Viqar ...................................... 102Martelli, Elizabeth ...................... 128, 272Martin, James F. ............................... 396Martinelli, Nidiane C. ......................... 318Martinez, Sabrina T. .......................... 267Martinez-Cruz, Mariana .................... 230Martinez Valencia, Eliana C. .............. 127Martins, Adriano S. ........................... 206Marvar, Paul ..................................... 465Mathison, Megumi ................ 33, 37, 363Mathiyalagan, Prabhu ....................... 206Matrougui, Khalid ............................. 447Matsa, Elena ..................................... 289Matsumoto, Junichi .......................... 105Matsushima, Shouji .......................... 105Matsuura, Katsuhisa ........................... 30Mattapally, Saidulu .............................. 41Mattos, Ana ...................................... 437Maxwell, Joshua T. ........................... 207Mayr, Manuel ...................................... 72McClung, Joseph M. ........................ 101McConnell, Mark ................................ 58McCreath, Lauren ............................. 412McCulloch, Christopher A. .................. 80McKnight, G. S. ................................ 238McKown, Elizabeth N. ...................... 352McLaughlin, Nathan .......................... 395McLean, Brent A. ............................... 80McNally, Elizabeth M. ........................ 391Meelu, Omar A. .................................. 49Meng, Qinghang ......................... 95, 269Menick, Donald R. ............................ 443Menini, Gabriele ................................ 242Mercader, Marco ...................... 303, 430Meredith, Andrea L. ............................ 61Mesubi, Olurotimi O. ......................... 459




AU

TH

OR

IND

EX

Methawasin, Mei ........................ 76, 398Michkov, Alexander ............................ 98Mielke, Thorsten ............................... 270Migrino, Raymond ............................ 380Mihalache-Avram, Téodora ............... 258Miller, Mickey ........................................ 3Miller, Yury ........................................ 307Milting, Hendrik ................................. 393Min, Hyun-Ki ............................. 241, 454Minamisawa, Susumu ......................... 68Miriyala, Sumitra ............................... 406Misaka, Tomofumi ............................ 404Mishra, Rachana .............. 208, 209, 351Miyamoto, Shelley D. .......... 57, 248, 416Miyamoto, Shigeki ............................ 123Miyata, Masaaki .................................. 42Mizuno, Yosuke ................................ 315Mizushima, Wataru ........................... 105Mohan, Maradumane L. ................... 423Mohan, Maradumane M. .................. 128Mohler, Peter J. .................................. 86Mohran, Saffie .................................... 48Mohsin, Sadia .......................... 2, 21, 84, .......................................... 298, 350, 364Molkentin, Jeffery D. ................ 222, 362, .......................................... 373, 421, 428Monji, Akio ........................................ 313Monsanto, Megan ............................ 350Monte, Emma ............................. 319, 50Montes, Guilherme C. ....................... 267Moon, Anne ........................................ 22Moorleghen, Jessica J. ..................... 252Morano, Ingo .................................... 239Moravec, Christine S. ............... 128, 259Moreno Vadillo, Cristina .................... 242Morikawa, Yuka ................................ 396Motayagheni, Negar ................. 253, 442Motloch, Lukas J. ............................. 229Moudgil, Meenal ........................... 27, 36Moukabary, Talal ................................. 71Moyzis, Alexandra G. ................ 103, 375Mukherjee, Rupak ............ 135, 309, 429Mullany, Lisa K. ............................. 33, 37Müller, Oliver J. ................................... 72Murakawa, Tomokazu ....................... 404Muramatsu, Toshihiro ....................... 315Murohara, Toyoaki ............................ 313Murphy, Anne ................................... 224Murray, Allan ..................................... 427Muselimyan, Narine .................. 430, 465Muthusamy, Senthilkumar ................. 354Myers, Ronald B. .............................. 108Nachar, Walid ................................... 258Nadeau, Elizabeth K. ........ 135, 309, 429Naeem, Nadia .................................. 367Naga Prasad, Sathyamangla ..... 128, 423Nagareddy, Prabhakara R. ................ 448Naguib, Mostafa R. ............................. 37Naim, Uzma ..................................... 312Nair, Pooja ........................................ 398Najor, Rita H. .................................... 223Nakagawa, Yasuaki .......................... 405Nakajima, Takayuki ........................... 105Nakano, Shintaro .............................. 315Nakao, Kazuwa ................................ 405Nakao, Tetsushi ................................ 277Nakashima, Yasuhiro ........................ 277Nakazeki, Noriko .............................. 277Nam, Deok Hwa ................................. 77Nan, Jing-Liang .................................. 78Nasr, Marjan ............................... 34, 354Nassal, Drew M. ............................... 259Natu, Vanita ...................................... 357Navankasattusas, Sutip .................... 412Navedo, Manuel F. ............................ 134Nchaw, Gladys A. ............................. 436

Negmadjanov, Ulugbek ..................... 102Neofytou, Evgenios ........................... 365Nevers, Tania ............................ 408, 424Newman, Mackenzie ........................ 140Nguyen, Jonathan ............................ 353Nguyen, Kim ..................................... 431Nguyen, Nicky .................................. 350Nguyen, Reginald T. ............................ 79Nickel, Barbara E. ............................. 374Nickoloff, Emily ...................... 24, 40, 99, .......................................... 220, 294, 298Nieman, Michelle ...................... 264, 428Nishida, Kazuhiko ............................. 404Nishiga, Masataka ............................ 277Nishikimi, Toshio ............................... 405Nishimura, Kazuyuki ......................... 313Nishimura, Shigeyuki ........................ 315Nishino, Tomohiro ............................. 277Nizet, Victor ...................................... 453Noble, Camille T. ................................. 25Norman, Benjamin ............................ 353Nunley, Karin .................................... 416Ocorr, Karen ..................................... 419Oganesian, Anush ............................ 308Ohishi, Mitsuru .................................... 42Okada, Muneyoshi ............................ 274Okoro, Emmanuel U. ................ 378, 462Olieslagers, Serve ............................... 26Olman, Mitchell A. ............................ 423Olsen, Virgílio ...................................... 70Olson, Eric N. ................................... 317O’Malley, Bert W. .............................. 129Ono, Koh .......................................... 277Ono, Minoru ....................................... 30Oppelt, Daniel ..................................... 62Orr, A. Wayne ........................... 222, 281Orr, Wayne ....................................... 406Osinska, Hanna .................. 95, 222, 269Otsu, Kinya ....................................... 404Oudit, Gavin Y. .................................... 80Ouyang, Brian .................................. 316Oyama, Mark A. ................................. 53Ozcan, Cevher .................................. 286Ozeroff, Christopher D. ..................... 382Padbury, James ................................ 243Palacios, Itziar .................................. 450Palaniyandi, Suresh S. ...................... 125Palmiter, Richard D. .......................... 401Pan, Guodong .................................. 300Panchatcharam, Manikandan ........... 406Pandey, Amitabh .............................. 360Paolocci, Nazareno ................... 113, 290Papait, Roberto ................................ 320Papanicolaou, Kyriakos N. ................ 436Parikh, Shan ....................................... 75Park, Eunhye ...................................... 51Park, Kyoung-mi ....................... 293, 312Park, Misun ...................................... 460Parker-Duffen, Jennifer L. ................. 436Parsons, Christopher ........................ 463Parvatiyar, Michelle S. ......................... 79Passariello, Catherine ............... 127, 306Pasterkamp, Gerard ........................... 55Patel, Krishan J. ............................... 314Patel, Vaibhav B. ................................ 80Patel, Vivekkumar ................. 33, 37, 363Pathan, Asif ................................ 34, 354Patil, Raveena ................................... 235Pattillo, Christopher B. ...................... 281Pattison, Scott .................................. 260Patwari, Parth ................................... 108Pellegrini, Matteo ................................ 50Pelonero, Angelo ................................ 64Pentoney, Amber N. ......................... 291Pereira, Rute ..................................... 450Perry, Justin B. ................................. 101

Peter, Angela K. ................................ 382Petovic, Jennifer L. ....................... 2, 364Pfleger, Jessica ................................. 106Phaelante, Amanda ............ 70, 268, 318Pham, Lisa ......................................... 51Phornphutkul, Chanika ..................... 243Pich, Andreas ..................................... 72Pike, Nirupama ................................... 51Ping, Xiaoli ........................................ 262Pinto, Graziela H. .............................. 318Platt, Colin ........................................ 422Pohl, Danielle .................................... 419Poizat, Coralie .................................. 390Pol, Christine J. ................................ 301Polavarapu, Rohini ............................ 438Polhemus, David ................................ 24Pollow, Dennis P. ................................ 94Ponnalagu, Devsena ........................... 61Portelli, Stefanie .................................. 60Posnack, Nikki .................................. 465Pott, Jost ............................................ 93Previs, Michael J. .............................. 389Pu, William ..................... 1, 91, 246, 440Puckelwartz, Megan J. ..................... 391Pun, Andres ............................. 113, 290Purcell, Nicole H. ................................ 45Qi, Yanmei ........................................ 361Qian, Li ............................................... 35Qiao, Weihua ...................................... 43Qin, Gangjian ............................. 43, 217, .......................................... 221, 356, 376Qin, Xulei .................................. 365, 366Qiu, Hongyu ............................. 407, 469Qiu, Jie ............................................. 226Qu, Liang-Hu ...................................... 91Quijada, Pearl ................................... 350Rabinowitz, Joseph E ......................... 24Rademaker, Miriam T. ....................... 265Raftery, Daniel .................................. 401Rahimi, Saum ................................... 361Ramachandran, Jayalakshmi ............ 255Ramirez, Trevi A. ............................... 425Ramirez-Navarro, Angelina ............... 259Rangel, Juliana O. ...................... 70, 268Rangrez, Ashraf Y. ............................ 393Raso, Andrea ..................................... 26Rau, Christoph ........................... 68, 133Ravandi, Amir ..................................... 36Razzaque, Shegufta ........................... 22Reaven, Peter ................................... 380Rebecchi, Mario J. ............................ 119Recamonde-Mendoza, Mariana ........ 318Rech, Monika ..................................... 81Reddy, Gopireddy R. ........................ 460Reddy, Nagender .............................. 232Reddy, Navya ................................... 232Reddy, Sushma ................................ 431Regitz-Zagrosek, Vera ................ 89, 400Reineke, Erin L. .......................... 77, 129Reloj, Allison R. ................................. 394Ren, Shuxun ..................................... 240Ren, Vincent ............................... 68, 247Ren, Yi .............................................. 218Rengo, Giuseppe ..................... 113, 290Repetti, Giuliana ............................... 360Rezvani, Khosrow ............................. 260Rhéaume, Éric .................................. 258Richards, Amanda ............................ 402Richards, Arthur M. ................... 54, 100, .................................................. 265, 414Ridley, Anne J. .................................... 90Riegler, Johannes ............................. 366Rios-Castro, Martha ................... 47, 383Ritter, Oliver ........................................ 62Ritterhoff, Julia .................................. 107Rizvi, Farhan ......................... 96, 97, 102


AU

TH

OR

IND

EX

Robbins, Jeffrey .......... 95, 222, 269, 393Roberts, Amy ............................... 1, 440Robertson, Elizabeth .......................... 60Rodriguez-Morales, Olivia ... 47, 230, 383Roe, Nathan ..................................... 437Rohde, Luis E. .................... 268, 70, 318Rokita, Adam G. ............................... 459Romay, Milagros ............................... 133Roos, Birthe ..................................... 401Roos, Kenneth P. ................................ 79Rosa Garrido, Manuel ............... 137, 319Roselli, Eric E. ................................... 244Rosengart, Todd ................... 33, 37, 363Rosenzweig, Anthony ............... 422, 445Ross, Gracious ..................... 96, 97, 102Rossi, Pier Luigi ................................ 320Rota, Marcello .................................. 386Rowe, Glenn C. ................................ 445Roy, Rajika .......................................... 82Rubino, Marcello ............................... 320Ruffenach, Gregoire .......................... 321Saadat, Siavash ................................ 361Sabbah, Hani N. ............................... 432Sadayappan, Sakthivel ..................... 389Sadeghi Pour, Pouya .......................... 52Sadoshima, Junichi .............. 73, 83, 222Safranski, David ................................ 219Saha, Progyaparamita ...................... 351Sahoo, Susmita ................................ 206Saito, Toshiro ...................................... 83Sakamoto, Tomoya ........................... 110Sakashita, Toku ................................ 315Salama, Guy ....................................... 39Salim, Asmat .................................... 367Salvador, Ane ................................... 424Salvador, Ane Miren .......................... 408Sanagasetti, Deepthi ............ 33, 37, 363Sanchez, Jessica N. ........................... 94Sanchez, Pablo .................................. 48Sandoval, Erik .................................. 431Sanina, Cristina ................................ 355Sano, Kazunori ................................... 30Sano, Motoaki .......................... 254, 287Santana, Luis F. ........................ 134, 238Sareen, Niketa .............................. 27, 36Sargent, Michelle A. .................. 373, 428Saripalli, Chandra ............................... 76Sarvazyan, Narine ............................. 430Sasaki, Yuichi ..................................... 42Sathyamangla, Prasad ...................... 272Satin, Jonathan ................................ 448Sato, Priscila ............................ 106, 449Saw, Eng Leng ........................... 54, 265Sawhney, J.P.S ................................. 452Sayed, Danish .......................... 138, 261Sayed, Nazish .................................. 289Schafer, Allison E. ............................. 409Schally, Andrew V. ........................ 56, 74Schmitt, Joachim ................................ 62Schocken, Derek ...................... 234, 384Schramm, Karla ................................ 455Schroen, Blanche ............................... 81Schuh, Kai .......................................... 62Schumacher, Sarah M. ............. 278, 301Schunke, Kathryn J. ......................... 120Schwartz, Benjamin ............................ 58Schwinn, Debra A. ............................ 308Sciarretta, Sebastiano ........................ 73Scott, Evan ....................................... 316Scott, John ....................................... 238Scott, Takara .................................... 283Scovotti, Jennifer ................................ 50Sebastião, Maria J. C. ...................... 450Seganish, Michael ............................ 252Seidman, Christine E. ....................... 417Seidman, Jonathan G. ...................... 417

Seki, Kaname ................................... 315Sekine, Hidekazu ........................ 30, 368Selzman, Craig ........................... 91, 412Semenkovich, Clay ........................... 312Sena, Emily S. .................................... 55Senbonmatsu, Takaaki ..................... 315Seo, Jae-Bin ..................................... 464Sequiera, Glen Lester ................... 27, 36Serio, Simone ................................... 320Serra, Margarida ............................... 450Serrano, Geidy ................................. 380Sessions, Ayla .......................... 419, 426Seyen, Sandrine R. M. ...................... 242Sha, Di ............................................. 233Shabani, Parisa ................................ 369Shah, Kajol ......................................... 61Shang, Ruru ..................................... 399Shao, Dan ................................ 107, 437Sharma, Manish ............................... 452Sharma, Sudhish .............. 208, 209, 351Sharma, Vikram .................................. 36Sharp, Thomas ....................... 28, 53, 84Shay-Winkler, Kritton ........................ 269Shehadeh, Lina ................................ 266Shen, Xiaolan ................................... 262Sheng, Wei ......................................... 22Sherman, Meredith ........................... 465Shi, Guangbin ................................... 285Shi, Jiawei .......................... 43, 217, 376Shi, Shihong ..................................... 457Shi, Yanfen ................................. 88, 258Shi, Yang .............................. 96, 97, 102Shih, Tsai-Ting .................................. 137Shimizu, Tatsuya ......................... 30, 368Shimizu, Yuuki .......................... 233, 438Shin, Eric .......................................... 210Shin, Hyewon ................................... 138Shirakabe, Akihiro ......................... 73, 83Shirakawa, Kohsuke ......................... 287Shires, Sarah E. .................................. 45Shirokova, Natalia ............................. 255Shivkumar, Kalyanam ....................... 314Shkedi, Omer ................................... 136Shohet, Ralph ............................. 59, 120Shukla, Praveen ............................... 289Siddiqi, Sailay ..................................... 26Siddiqui, Ramail .................................. 96Signore, Sergio ................................. 386Silva, Ananssa M. S. ......................... 410Silva, Thiago F. ................................. 410Silvello, Daiane ................................. 318Singh, Bhairab N. ............................. 370Singh, Harpreet .................................. 61Singh, Jayanti ................................... 266Singh, Krishna K. .............................. 250Singh, Monalisa ................................ 219Singh, Saurav ................................... 455Singh, Vivek P. ...................... 33, 37, 363Singh-Gupta, Vinita .......................... 432Siragusa, Mauro ................................. 87Sivaguru, Mayandi ............................ 389Slater, Rebecca E. .............................. 76Sluijter, Joost P. G. .............................. 55Small, Kersten ............................ 53, 262Smith, Jeffrey D. ............................... 448Smith, Jennifer L. .............................. 394Smith, Jessie A. ................................ 284Smith, Jonathan D. ........................... 470Snyder, Michael P. ............................ 289Soehalim, Elizabeth .......................... 137Somvanshi, Sonal ............................... 37Song, Long-Sheng ................... 237, 459Song, LouJin .................................... 111Soo, Sherilynn .................................. 395Sorrentino, Andrea ............................ 386Spätjens, Roel L. H. .......................... 242

Spenlehauer, Alice ............................ 419Sporbert, Anje .................................. 239Sreedhar, Remya ...................... 125, 256Sriram, Krishna ................................... 98Stanford, Kristin I. ............................. 411Starling, Randall ............................... 128Starosta, Timothy ........... 2, 28, 296, 364Stauffer, Brian ..................................... 57Stauffer, Brian L. ....................... 248, 416Stauffer, Winston T. ................... 211, 291Steinberg, Susan F. .......................... 460Stephens, Haley N. ........................... 211Stirparo, Giuliano .............................. 320Stohlman, Jayna ....................... 234, 384Stoll, Shaunrick ................................ 469Stotland, Aleksandr .......................... 431Strauss, David .......................... 234, 384Strom, Joshua ............................ 76, 398Stroud, Robert E. ............. 135, 309, 429Sturza, Daniel ................................... 268Sucharov, Carmen C. ............... 248, 416Sucharov, Kika .................................... 57Sucov, Henry .................................... 457Sudo, Roberto T. ...................... 267, 410Suh, Ji Ho .......................................... 77Suleman, Amer ................... 46, 227, 228Sullivan, Mara ..................................... 39Sultana, Nishat ................................... 22Sun, Haipeng ................................... 104Sun, Jian .......................................... 385Sun, Shu-Yu ............................... 53, 262Sun, Zhongjie ................................... 263Sung, Kevin ........................................ 68Suresh Babu, Sahana .............. 200, 204, .................................................. 372, 461Sussman, Mark ........................ 350, 353Suzuki, Kenji ..................................... 256Svinkina, Tanya ................................. 445Swiercz, Adam ................................. 465Swift, Luther ..................................... 430Szaraz, Peter .............................. 31, 358Szaroszyk, Malgorzata ........................ 72Szeto, Christopher ............................ 122Taegtmeyer, Heinrich ................ 129, 467Taffet, George E. ............................... 129Tajik, A. Jamil ................................ 96, 97Takada, Shingo ................................. 105Takahashi, Hidehisa .......................... 105Takawale, Abhijit R. ........................... 427Takeuchi, Lauro M. ....................... 56, 74Takeuchi, Rosemeire K. ...................... 66Tal-Grinspan, Lauren .......... 58, 257, 402Tallquist, Michelle D. ........................... 92Tamura, Natsuko .............................. 403Tamura, Noriko ................................. 295Tan, Nicholas .................................... 470Tan, Yi ...................................... 279, 385Tang, Mingxin ........................... 122, 134Tang, Xiaoqiang ................................ 434Tang, Yan ................................... 139, 40Tanno, Jun ........................................ 315Tan-Sah, Valerie P. ............................ 123Tanwar, Vineeta ................................ 411Tao, Ge ............................................. 396Tardif, Jean-Claude ........................... 258Tardiff, Jil C. ........................ 58, 257, 402Tatman, Phillip .................................. 416Taylor, Doris ........................................ 29Taylor, William R. ............................... 210Taylor-Weiner, Hermes ...................... 109Tenerelli, Kevin .......................... 109, 288Teoh, Jian P. ..................................... 112Teoh, Jian-peng ................................ 310Terentyev, Dmitry .............................. 285Termglinchan, Vittavat ....................... 289Thakur, Hrishikesh .................... 127, 306




AU

TH

OR

IND

EX

Thandavarayan, Rajarajan A. ........... 125, .................................. 204, 256, 372, 461Thoemmes, Stephen F. ..................... 249Tholey, Andreas ................................ 393Thomas, Robert L. ............................ 375Thomas, Stephanie .......................... 288Thum, Thomas ................................... 72Tian, Rong ................ 104, 107, 401, 437Tian, Shuo ........................................ 215Tian, Xiaoxiang ................................. 361Tian, Ying ........................................... 67Tiburcy, Malte ............................. 366, 90Tiedje, Christopher ............................. 72Tilley, Douglas ................................... 451Tirouvanziam, Rabin ......................... 210Tobita, Kimimasa ................................ 39Toib, Amir ................................... 84, 296Toischer, Karl .................................... 400Tomasi, Loreta D. ............................. 437Tompkins, Christine .......................... 248Topol, Eric ........................................ 288Trac, David Q. ................................... 212Trachez, Margarete M. ...................... 410Tracy, Christopher M. ........................ 412Tran, Diana ......................................... 64Tran, Khanh-Van ............................... 397Tran, Vivien ....................................... 109Trappanese, Danielle .......................... 28Trappanese, Danielle M. ............... 21, 84Travers, Joshua G. ............................ 428Traynham, Christopher J. .................. 449Trebak, Mohamed ............................ 447Tremblay, Michel ................................. 88Troupes, Constantine .......................... 21Troupes, Constantine D. .......... 2, 53, 84, .................................................. 298, 364Truitt, Rachel E. ................................ 225Trujillo, Adriana S. ............................. 419Truran, Seth ...................................... 380Tsang, Alvin M. ................................. 101Tsang, Tien-Jui ................................. 371Tseng, Yi-Tang .................................. 243Tsuda, Masaya ................................. 105Tsutsui, Hiroyuki ................................ 105Tuler, Jeremy .................................... 419Tumuluru, Samvruta ............................ 75Ueno, Kazuyuki ................................ 256Umar, Soban .................................... 321Umar, Zein .......................................... 32Valarmathi, Mani T. ........................... 213Valasaki, Krystalenia ......................... 355Valencia, Eliana C. ............................ 306Valenti, Mesele-Christina ................... 301Valiente-Alandi, Iñigo ................ 264, 409van Berlo, Jop H. ........................ 218, 23van Bilsen, Marc ................................. 81van Dijk, Sabine J. .............................. 85Van Eyk, Jennifer E. .......................... 419Vanhaesebroeck, Bart ........................ 80van Hout, Geert P. .............................. 55Van Wagoner, David R. ............. 244, 470Varol, Erdem ....................................... 28Vasquez, Hernan .............................. 467Vedula, Indira .................................... 284Vega, Rick B. .................................... 110Velazquez, Francisco ................ 408, 424Venkata Naga Srikanth, Garikipati ..... 200Venkatraman, Vidya .......................... 419Verma, Suresh ............................ 220, 40Verma, Suresh K. .......... 24, 99, 139, 294Verma, Vipin K. ..................... 69, 75, 280Vicente, Jose ............................ 234, 384Vohra, Jayati ..................................... 452Volders, Paul G. A. ........................... 242Vondriska, Thomas ............................. 50Vondriska, Thomas M. .............. 137, 319

Wagner, Mary B. ............................... 207Wakimoto, Hiroko ............................. 417Walker, Lori A. .......................... 248, 249Wallner, Markus .............. 28, 53, 84, 296Wallukat, Gerd .................................. 460Walsh, Kenneth ................................ 436Walton, Chad ............................. 59, 120Wamelink, Mirjam M. C. .................... 401Wan, Xiaoping .................................. 259Wang, Bing F. ................................... 108Wang, Charles .................................. 469Wang, Chunlin .............................. 24, 40Wang, Da-Zhi ..................................... 91Wang, Fei ......................................... 114Wang, Gang ................................. 1, 440Wang, Guang-rong ........................... 251Wang, Guey-Shin ............................. 466Wang, Hao ....................................... 267Wang, Hong ..................................... 134Wang, Huan ..................................... 399Wang, Jessica .......................... 133, 350Wang, Jian’an ..................................... 78Wang, Juan ...................................... 414Wang, Lanfang ................................. 210Wang, Li ............................................... 3Wang, Meng-long ............................. 216Wang, Mingyi .................................... 419Wang, Peipei ...................... 100, 265, 54Wang, Qing k. ................................... 468Wang, Shudong ............................... 279Wang, Tao ................................ 116, 296Wang, Xi ........................................... 272Wang, Xiaohui .......................... 117, 214Wang, Xiuhua ................................... 427Wang, Xuejun “XJ” .................... 131, 302Wang, Yibin ......................... 50, 68, 133, .......................................... 137, 240, 247Wang, Yihui ...................................... 237Wang, Ying-Chao ............................... 78Wang, Yongchao .............................. 293Wang, Zhao ...................................... 121Wang, Zhijie ...................................... 468Wang, Zhiqiang ................................ 235Wang, Zhong .................................... 215Wanjare, Maureen ............................... 38Warren, Junko S. .................................. 3Warshaw, David M. ........................... 389Watanabe, Kenichi .................... 125, 256Watanabe, Masashi .......................... 105Watanabe, Yuki ................................. 274Watson, Michael J. ........................... 140Wehrens, Xander H. T.. ..................... 459Weigand, Kyle ............................ 71, 360Weisleder, Noah ................................. 86Wen, Ying ......................................... 216Werner, Paul ....................................... 97Westphal, Christina ............................. 89Wheeler, Jason B. ............................. 429Williams, Allison L. .............................. 59Williams, Anna .................................. 439Williams, David ......................... 117, 214Williams, Tatjana ................................. 62Winfrey, William B. ............................ 101Wisniewski, Nicholas .......................... 50Withers, Catherine N. ....................... 448Witte, Russell ...................................... 71Wold, Loren E. .................................. 411Wollert, Kai C. ..................................... 72Wong, Kirsten ................................... 288Wong, Lee L. .................................... 414Wong, Lee Lee ........................... 54, 265Woodgett, James R. ........................... 69Woulfe, Kathleen C. .................. 248, 416Wouters, Kristiaan .............................. 81Wright, Mariah .................................. 244Wu, Gengze ....................................... 91

Wu, Haodi ........................................ 289Wu, Jian ................................... 130, 457Wu, Joseph ...................................... 366Wu, Joseph C. ................. 289, 365, 406Wu, Jun .............................................. 31Wu, Penglong ................................... 302Wu, Rongxue .............................. 63, 392Wu, Yan .............................................. 78Wu, Yong .......................................... 319Wysoczynski, Marcin ............ 25, 34, 354Xia, Ying ........................................... 226Xiang, Qian ......................................... 29Xiang, Yang K. .................................. 460Xiao, Chunyang ................................ 422Xiao, Dan .......................................... 365Xiao, Hua ............................................ 72Xiao, Kunhong .................................. 106Xiao, Xinshu ........................................ 68Xie, Chaoqin ............................. 229, 441Xie, Lai-Hua ...................................... 255Xie, Xue-Min ..................................... 434Xu, Chunhui .............................. 212, 219Xu, Hao .............................................. 96Xu, Haodong .................................... 311Xu, Jian .................................... 130, 457Xu, Mingjiang ...................................... 22Xu, Yanchun ..................................... 243Xu, Zhaobin ........................................ 86xu, Zheng ......................................... 385Yamada, Chinatsu ............................ 405Yamamoto, Tadashi .......................... 379Yamamoto, Tsunehisa ....................... 287Yamashita, Kaoru ............................. 254Yamawaki, Hideyuki .......................... 274Yan, Chenghui .................................. 361Yan, Jianyun ....................................... 22Yan, Xiaoqing .................................... 279Yan, Yasheng .................................... 439Yang, Chunjie ................................... 276Yang, Han-Mo .................................... 65Yang, Hong .............................. 378, 462Yang, Huaxiao .................................. 365Yang, Jian-Hua ................................... 91Yang, Jianchang ................... 33, 37, 363Yang, Lei ............................................ 39Yang, Liming ..................................... 262Yang, Lina .......................................... 37Yang, Liu .................................. 217, 376Yang, Tingli ....................................... 114Yang, Xiangsheng ............................. 114Yang, Yijun ............................ 2, 116, 364Yang, Zhi .................................. 138, 261Yanucil, Christopher .......................... 455Yazawa, Masayuki ............................ 111Ye, Bo .............................................. 311Ye, Yong ........................................... 276Yellamilli, Amritha ........................ 23, 218Yi, Sijia .............................................. 316Yi, Xin ............................................... 114Yin, Haifeng ................................ 238, 44Yin, Xiaoke .......................................... 72Yokota, Takashi ................................ 105Yokota, Tomohiro ................................ 68Yonezawa, Aline L. ........................... 219Yoon, Somy .............................. 241, 454Yoshida, Azumi ................................... 30Yoshida, Naohiro .............................. 254Yoshioka, Jun ................................... 108Youker, Keith A. ........................ 372, 461Yousefi, Keyvan ................................ 266Yousufuddin, Mohammed ................. 102Yu, Daohai ........................................ 296Yu, Han-Gang ................................... 140Yu, Hong ............................................ 78Yu, Huidan W. ................................... 235Yu, Kun-Hsing .................................. 289


AU

TH

OR

IND

EX

Yu, Yang ........................................... 217Yuan, Ancai .............................. 301, 449Yue, Xiaojing ..................................... 114Yue, Yujia ............................ 40, 139, 294Yuzyuk, Tatiana N. ................................ 3Zacchigna, Serena .............................. 26Zafir, Ayesha ....................................... 25Zaitsev, Alexey V. .................................. 3Zapata-Sudo, Gisele ................. 267, 410Zayed, Mohamed A. ......................... 312Zelarayan, Laura C. .......................... 400Zemskova, Marina ............................ 210Zeng, Chunyu ..................................... 91Zhabyeyev, Pavel ................................ 80Zhai, Peiyong ...................................... 83Zhang, Aijun ..................................... 284Zhang, Chen ...................................... 84Zhang, Guoping ............................... 276Zhang, Hanming ............................... 131Zhang, Jianyi ...................................... 41Zhang, Jin ........................................ 399Zhang, Liyan ..................................... 282

Zhang, Lu ........................................... 22Zhang, Ningya .................................. 378Zhang, Pu ......................................... 427Zhang, Qing ....................................... 68Zhang, Qinkun ...................... 69, 75, 280Zhang, Tingwei ................................. 130Zhang, Xian-zheng ........................... 216Zhang, Xiaoxiao .......................... 84, 296Zhang, Xiaoyi .................................... 276Zhang, Xiaoying ........................ 122, 134Zhang, Xiaoyu ........................... 234, 384Zhang, Yi ............................................ 87Zhang, Zhen ..................................... 104Zhao, Huawei ................................... 262Zhao, Jing .......................................... 78Zhao, Meng ........................................ 41Zhao, Mingming ............................... 431Zhao, Xiang ...................................... 434Zhao, Xin .......................................... 365Zheng, Mei ................................. 63, 392Zheng, Shuqin .................................. 262Zheng, Yang ..................................... 279

Zhong, Wei ....................................... 283Zhong, Zhi-Wei ................................... 78Zhongjian, Cheng ............................. 220Zhou, Anyu ....................................... 285Zhou, Bin ............................................ 22Zhou, Jibin ........................... 24, 40, 220Zhou, Junlan .................... 221, 356, 376Zhou, Ning ....................................... 407Zhou, Yang ......................................... 35Zhou, Yue ................................... 54, 100Zhu, Lian-lian ...................................... 78Zhu, Wei ..................................... 78, 302Zhu, Wuqiang ............................... 23, 41Zhu, Yuanjia ...................................... 244Zimmermann, Wolfram ............... 90, 366Zo, Joo-Hee ..................................... 464Zohrabian, Sylvia .............................. 246Zou, Jun ............................................. 64Zou, Yunzeng ................................... 276Zuttion, Marilia .................................... 74Zwetsloot, Peter-Paul ......................... 55


Your invitation to submit to JAHA – Journal of the American Heart Association

Submit at: jaha-submit.aha-journals.org

Rapid publication—Articles are online within 4 weeks of acceptance after payment of the article publication charge

Fully compliant with Open Access mandates—JAHA meets the requirements of funding organizations and institutions

Discounted article publication charges for AHA/ASA members—Find out more online

JAHA offers you the ability to present all aspects of your work—No restrictions on article length and unlimited use of color images and video

Indexed widely—Searchable in MEDLINE® and indexed in Thomson Reuters Science Citation Index ExpandedTM. See a complete list of where JAHA is indexed at jaha.ahajournals.org


Notes

Program at a GlanceSunday July 17

Monday July 18

Tuesday July 19

Wednesday July 20

Thursday July 21

7:00 am 7–8:00 am Continental Breakfast/Registration/Exhibits

7–8:00 am Continental Breakfast/Registration/Exhibits

7–8:00 am Continental Breakfast/Registration

8:00 am 8:00–9:50 am Session 4Mitochondrial Dynamics and Quality Control

8:00–9:30 am Session 8Organ on a Chip: iPS Cells in Disease Modeling of Cardiovascular System

8:00–9:20 am

Session 13Genomic and Epigenomic Medicine: Current Frontiers

9:00 am 9:20–9:30 am

Break

9:30 am 9:50–10:05 am


9:30–9:45 am


9:30–10:50 am

Session 14Systems Biology and Genetic Approaches to Novel Therapeutics

10:00 am 10:00 am Registration/Exhibits

10:05–11:55 am Session 5Novel Mediators of Cardiac Cell Death and Aging

9:45–11:55 am

Session 9Cardiac Development and Congenital Disease

10:30 am

11:00 am 11:55–12:05 pm

Special Tribute to Arnold M. Katz, MD

10:50 am–12:10 pm

Session 15Cardiac Regeneration: Bench to Bedside

NOON NOON–6:00 pm ACRE Meeting(Academy of Cardiovascular Research Excellence)

NOON–1:30 pm Early Career Workshop/Lunch 1Ticket required to attend

12:05–1:15 pm Early Career Workshop/Lunch 2Ticket required to attend

12:10 pm Adjourn

1:00 PM 1:00–1:20 pm Welcome Remarks

1:30 PM 1:20–3:10 pm Session 1Mechanisms of Cardiac Energy Production and Stimulation

1:30–3:20 pm Session 6 Non-coding and Extracellular RNAs as Modulators of Cardiovascular Disease

1:15–2:00 pm Session 10 Outstanding Early Career Investigator Finalist Competition

2:00 PM 2:00–3.50 pm Session 11Calcium Regulation in Heart Failure

3:00 PM 3:20–3:30 pm Refreshment Break/Exhibits

3:30 PM 3:10–3:55 pm Session 2 Keynote Lecture

3:30–5:20 pm Session 7 Signaling Mechanisms of Heart Function and Failure: Novel Insights

3:50–4:05 pm Refreshment Break/Exhibits

4:00 PM 3:55–4:10 pm Refreshment Break

4:05–5:55 pm Session 12 Non-conventional Players in Cardiac Healing and Regeneration4:30 PM 4:10–6:00 pm

Session 3 Exosomes, Extracellular Vesicles and Cardiovascular Function

5:00 PM


6:00–7:30 pm Poster Session 3


6:30 PM

7:00 PM

7:30 PM 7:30–10:30 pm

Council DinnerTicket required to attend

Plenary Session

Poster Session

Meals/Breaks

Other

Legend

SAVE THE DATE!


July 10 –13 | Portland Executive Tower | Portland, Oregon


Life is why.Research and Patient Care are how.

The American Heart Association Professional Membership is where you’ll find the richest source of cardiovascular science and news. Enhance your knowledge, experience and networking with a membership today!

Professional Membership Benefits Include:*• Up to $400 in savings on AHA’s scientific conferences

• Unprecedented access to research and clinical information across multiple specialties

• Be a part of our AHA Professional Online Network — connect with peers and leaders in your specialty

• The research grant application fee is waived for members.

• Online access to all 11 AHA scientific journals of your choice*

• Complimentary access to Sessions OnDemandTM*

*dependent on membership tier

Learn about the benefits of professional membership and join our network of more than 33,000 members today at professional.heart.org.

Members are where it happensJoin/Renew today!

National Center

7272 Greenville Avenue

Dallas, Texas 75231–4596

©2016, American Heart Association 6/16JN0525


Cardiovascular diseases and stroke afflict people of all races, ethnicities, genders, religions, ages, sexual orientations, national origins and disabilities. The American Heart Association is committed to ensuring that our workforce and volunteers reflect the world’s diverse population. We know that such diversity will enrich us with the talent, energy, perspective and inspiration we need to achieve our mission: building healthier lives, free of cardiovascular diseases and stroke.

professional.heart.org/bcvs

Sponsored and organized by the Council on Basic Cardiovascular Sciences.

Basic Cardiovascular Sciences 2016 Scientific Sessions: Pathways to Cardiovascular Therapeutics

BCVS 2016

Final ProgramJuly 18–21 | Hyatt Regency Phoenix | Phoenix, Arizona

bcvs 2016 program agenda (pdf)

Documents