bacterial disease, part 2 fs/lectures/05_bacteriaآ  • nervous system involvement...

Download Bacterial Disease, Part 2 FS/Lectures/05_Bacteriaآ  • Nervous system involvement (meningitis, encephalitis,

If you can't read please download the document

Post on 04-Jul-2020

0 views

Category:

Documents

0 download

Embed Size (px)

TRANSCRIPT

  • Microbiology FS – Bacterial Disease, Part 2 Reading Outline

    Page 1

    Bacterial Disease, Part 2 Reading Outline - Module 5

    Textbook readings:

    Bacterial Diseases – Part #2 Chapter 25, Pages 357-371

    Lyme Disease 357-358 Syphilis 358-360 Cholera 360 Anthrax 361-362 Whooping Cough 362-363 Escherichia coli 363-3364 Klebsiella sp. and Proteus sp. 364 Diseases caused by Salmonella sp. 365 Bubonic Plague 366 Haemophilus influenzae 367 Campylobacter sp. 367-368 Helicobacter pylori 368-369 Legionella pneumophilia 369 Listeria monocytogenes 369-370

    1. Borrelia burgdorferi (Pages 357 – 358)

    A. Disease: Lyme Disease

    B. Etiology: See handout on Lyme Disease

    i. Vector: Deer Tick

    ii. Reservoir: Many vertebrate animals (mice, rabbits, etc.)

    iii. Symptoms

    a. First: “Bulls Eye Rash” or erythema migrans (60%)

    b. Second: Flu like symptoms

    https://en.wiki pedia.org/wiki /Spirochaete

    If anything on the outline is GREY, you are NOT responsible for it. You may ignor it.

  • Microbiology FS – Bacterial Disease, Part 2 Reading Outline

    Page 2

    c. Third

    • Heart damage (may need pacemaker)

    • Nervous system involvement (meningitis, encephalitis,

    paralysis)

    • Arthritis due to auto-immune response

    2. Treponema pallidum (Pages 358 – 360)

    A. Disease: Syphilis

    B. Etiology

    i. Reservoir: Man

    ii. Historical overview

    iii. Etiology

    a. Spread by contact with lesions (not fomites)

    b. Stages

    • Primary

    * Ulcer / Chancre - Note highly infectious exudate

    * No systemic signs or symptoms, but …

    * Systemic spread of organism

    * Ulcer / Chancre vanishes

    • Secondary

    * Flu like symptoms, swollen lymph nodes

    https://en.wikipe dia.org/wiki/Rapi d_plasma_reagin

  • Microbiology FS – Bacterial Disease, Part 2 Reading Outline

    Page 3

    * Rash on feet and palms of hands

    * Lesions occurring are highly infectious

    * 25% heal, 25% latent infection, 50% go on to the

    tertiary stage

    • Tertiary

    * Large lesions called “Gummas” occur on organs of

    the body, skin

    * May lead to death

    iv. Antibiotics

    3. Vibrio cholerae (Page 360)

    A. Disease: Cholera

    B. Etiology

    i. Reservoir: Man

    ii. Enterotoxin results in electrolyte and water loss

    a. Cardiovascular Collapse and Death

    4. Bacillus anthracis (Page 361 - 362)

    A. Disease: Anthrax

    B. Virulence Factors

    i. Endospores

    ii. Encapsulated

  • Microbiology FS – Bacterial Disease, Part 2 Reading Outline

    Page 4

    iii. Reservoir: Livestock

    C. Anthrax in Humans

    i. Cutaneous Anthrax

    a. Lesion Develops

    b. Potential septic infection

    ii. Pulmonary (or Inhalation) Anthrax

    a. Flu like symptoms

    b. Respiratory distress

    c. Respiratory failure, along with other complications

    iii. Gastrointestinal Anthrax – through ingestion of endospores

    a. Lesions develops on intestinal mucosa

    b. Serious gastroenteritis occurs (see list of symptoms)

    5. Bordetella pertussis (Pages 362 – 363)

    A. Disease: Whooping Cough or Pertussis

    B. Etiology

    i. Transmitted by respiratory droplets

    ii. Communicable disease of children

    iii. Asymptomatic carriers (adults)

    iv. Exotoxins damage respiratory tract cilia

    v. Mucous becomes respiratory blockage

  • Microbiology FS – Bacterial Disease, Part 2 Reading Outline

    Page 5

    vi. Coughing response occurs to remove blockage

    C. DTaP Vaccine

    6. Escherichia coli (Pages 363 – 364)

    A. Organism is member of normal flora

    B. Diseases of Virulent Strains

    i. Traveler’s Diarrhea – Causes water and electrolyte loss

    a. Transmission – Fecal / Oral Route

    ii. Hemorrhagic diarrhea – invasive strains progress to bloody diarrhea as

    mucosa is invaded by bacteria

    iii. Transmission – undercooked meat, unpasteurized milk, etc.

    7. Klebsiella pneumoniae (Page 364)

    8. Proteus vulgaris (Page 364)

    A. Obligate Saprophyte and aerobe

    B. Diseases

    i. Ear Infections

    ii. Infections of wounds and burns

    C. Inhibits effect of formaldehyde, protein cross-linking fails

    9. Salmonella enteritidis (Page 365)

    A. Fimbrial Adhesion

    B. Disease: Salmonellosis

    https://en.wikipe dia.org/wiki/Esch erichia_coli

  • Microbiology FS – Bacterial Disease, Part 2 Reading Outline

    Page 6

    i. Watery Diarrhea

    ii. Abdominal Cramps

    iii. Rarely: Septicemia

    C. Transmission – contaminated food, particularly poultry, eggs, meat

    10. Salmonella typhi (Page 365)

    A. Reservoir: Humans

    B. Transmission: Fecal /Oral Route

    C. Disease: Typhoid Fever

    i. Lesions of digestive tract

    ii. Hemorrhaging resulting in nose bleeds and red spotting on abdomen and

    Chest.

    D. Asymptomatic Carriers

    i. Gall Bladder

    11. Shigella sp. (Page 366)

    A. Reservoir: Humans and primates

    B. Transmission: Fecal /Oral Route vie flies, fomites, water, food etc.

    C. Disease: Shigellosis or Bacillary dysentery

    i. Shigella toxin

    ii. Bloody mucoid stools

  • Microbiology FS – Bacterial Disease, Part 2 Reading Outline

    Page 7

    12. Yersinia pestis (Page 366)

    A. Reservoir: Rodents and other small vertebrates

    B. Vector: Rat Flees

    C. Transmission Routs

    i. Rat Flees à Blood à Lymph Node Enlargement (Buboes)

    ii. Pneumonic Plague (person to person)

    D. Disease: Bubonic Plague (or Black Death)

    13. Haemophilus influenzae (Page 367)

    A. Reservoir: Humans, often as normal flora

    B. Disease: Influenzal meningitis (not to be confused with Influenza, which is

    viral)

    C. Virulence Factors

    i. Capsule

    D. Damages function of cilia

    14. Campylobacter jejuni (Page 367)

    A. Reservoir / Transmission: Cats, Dogs, Birds, contaminated

    water and food

    B. Disease: Gastroenteritis

    i. Symptoms

    https://en.wikipe dia.org/wiki/Cam pylobacter_jejuni

  • Microbiology FS – Bacterial Disease, Part 2 Reading Outline

    Page 8

    15. Helicobacter pylori (Pages 367 - 379)

    A. Disease: Peptic and Duodenal Ulcers

    16. Legionella pneumophilia (Page 369)

    A. Disease: Legionellosis

    B. Reservoir: Water reservoirs, air conditioning

    units, shower heads etc.

    C. Transmission: Airborne aerosols

    D. Symptoms: Fever, Cough à pneumonia

    17. Listeria monocytogenes (Pages 369 - 370)

    A. Disease: Listeriosis, in immunocompromised

    individuals

    i. Listeriosis, in immunocompromised

    individuals

    ii. Asymptomatic in adults

    iii. 60 % mortality rate among the unborn

    B. Transmission: Food such as cold cuts, cheese, milk and others.

    C. Reservoir: Many animals

    D. Transmission: Fecal / Oral Route

    Legionella pneumooophila

    https://en.wikipe dia.org/wiki/Legi onella_pneumop hila

    Listeria monocytogenes

    https://en.wikipedia.org/wiki/Le gionella_pneumophila

Recommended

View more >