wurster coating
Post on 23-Jan-2017
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Wurster CoatingJulia Lau
What is it? “…technology for
precision application of a film coating onto
particulate materials such as powders,
crystals, or granules. ”
How it Works
1. Filler particles are loaded into the chamber and moved by the fluid bed in a cyclic pattern.
2. Spray nozzle at the bottom of the fluid bed atomizes the coating solution (solvent + coating material) and sprays concurrently with the moving particles.
3. Particles are suspended into the expansion chamber where the solvent evaporates and leaves behind the coating material
Why We Use it for Client 1300 API
API Characteristics- Very soluble in water (hygroscopic)- Low melting point (mp: 89-100°C)- Clumps together; does not flow well - Particle size distribution is not
uniform
Wurster Coating- Reduce moisture
uptake- Control particle size - Improve flow- Achieve a uniform
blend
Why choose Wurster Coating vs. Other Methods
•Formulation 1: API based melt granulation•Formulation 2: Ethyl Acetate based high shear granulation•Formulation 3: Wurster Coating
Tests PerformedVisual Observation
Water ContentSieve Cut Studies
Moisture Study: Visual Observations
Visual observation of blends
-Discoloration-Flow-Agglomerates/clumping
F1 F3F2
T= 0 days
T= 9 days
F1 F2 F3
Moisture Study: Water Content
Water content after T=0,1,2,6,7,8,9
days
Time Point (Days)Formulation# 1 Formulation# 2 Formulation# 3
%WC %WC %WC0 4.46 3.48 2.961 7.46 7.65 6.892 7.18 7.36 7.416 7.44 6.94 6.457 6.72 7.01 7.008 7.31 7.47 6.589 7.28 7.56 6.67
Sieve Cut StudiesSieve Fraction Size
Weight of Formulation on Screen (g)
Percent Sieve Fraction % Potency
Weighted Mean % Potency
710 μm < x < 1000 μm 0.8462 4% 260.9
83.1425 μm < x < 710 μm 2.8319 14% 227.7250 μm < x < 425 μm 4.5223 23% 83.175 μm < x < 250 μm 11.1656 56% 35.0
< 75μm 0.4967 3% 39.0
Total 19.8627
Sieve Fraction SizeWeight of
Formulation on Screen (g)
Percent Sieve Fraction % Potency
Weighted Mean % Potency
710 μm < x < 1000 μm 0.2896 1% 295.5
96.5425 μm < x < 710 μm 2.5318 12% 279.3250 μm < x < 425 μm 5.1688 25% 93.975 μm < x < 250 μm 11.2686 55% 56.1
< 75μm 1.2425 6% 55.1
Total 20.5013
Sieve Fraction SizeWeight of
Formulation on Screen (g)
Percent Sieve Fraction % Potency
Weighted Mean % Potency
710 μm < x < 1000 μm 1.0956 5% 101.0
100.7425 μm < x < 710 μm 10.4002 51% 101.0250 μm < x < 425 μm 7.6452 37% 101.375 μm < x < 250 μm 1.1789 6% 106.2
< 75μm 0.1849 1% 21.8
Total 20.5048
Formulation 1: API Based
Melt Granulation
Formulation 2: Ethyl Acetate
Based Granulation
Formulation 3: Wurster
Coating
Other Applications
Industry ApplicationPharmaceutical - Coating drugs (prolong shelf life, masking odor/taste of drug)
- Control drug release in the body (delayed, enteric, sustained, extended etc.)- Coating capsules
Food - Mask certain flavors- Improve stability and shelf life- Extended release of flavors (e.g. gum)
Chemical - Control release properties of chemicals- Change absorption/surface properties- Isolate active chemical in a mixture
Agricultural - Coat seeds for easier handling (e.g. increase size for machine planting)- Improve crop yields and/or germination by coating seeds with pesticides or nutrients.
Animal Feed - Mask taste of products to improve palatability for animals- Control release of product after ingestion - Stabilize medicine by coating
Nutrition - Optimize stability of an ingredient or product - Control ingredient release properties
References
- “The Wurster Process- Coating Place, Inc.” The Wurster Process - Coating Place, Inc. Web. 14 Aug. 2015.
- Nate Barksdale- Vijay Taladi
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